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568 results on '"Maurizi, M."'

9. Hypofolatemia as a risk factor for head and neck cancer

Author

Almadori, G., Bussu, F., Galli, J., Cadoni, G., Paludetti, G., Maurizi, M., Almadori G. (ORCID:0000-0002-4605-2442), Bussu F. (ORCID:0000-0001-6261-2772), Galli J. (ORCID:0000-0001-6353-6249), Cadoni G. (ORCID:0000-0001-8244-784X), Paludetti G. (ORCID:0000-0003-2480-1243), Maurizi M., Almadori, G., Bussu, F., Galli, J., Cadoni, G., Paludetti, G., Maurizi, M., Almadori G. (ORCID:0000-0002-4605-2442), Bussu F. (ORCID:0000-0001-6261-2772), Galli J. (ORCID:0000-0001-6353-6249), Cadoni G. (ORCID:0000-0001-8244-784X), Paludetti G. (ORCID:0000-0003-2480-1243), and Maurizi M.

Abstract

Head and neck cancer (HNSCC) includes squamous cell carcinomas of the oral cavity, pharynx and larynx. Approximately 38,500 cases of HNSCC are estimated to occur in the USA in 2004, with 11,000 deaths. HNSCCs represent about 3% of all malignant tumors in the USA. However, in other parts of the world, as India, Southeast Asia or Brazil, the disease is much more prevalent. The standard therapeutic approach, focused on surgery, irradiation and chemotherapy, alone or in combination, has been in part modified in the last 30 years, but the overall survival of HNSCC patients has not substantially improved. To characterize and thus identify high-risk mucosal areas and preclinical tumors, molecular abnormalities in head and neck carcinogenesis have been extensively studied. Metabolic aspects in head and neck carcinogenesis have been less extensively studied. Nevertheless, we know that metabolic alterations, often aspecific, are frequently associated with cancer. These may be secondary or may precede tumor development and favorite progression. In particular, based upon our results, a role for folate deficiency as a risk factor in head and neck carcinogenesis seems plausible. A chemoprevention protocol with folate is at present feasible and ethically correct and is already in progress at our institution. Homocysteine levels in cancer patients are probably largely affected by the HNSCC phenotype. An accumulation of homocysteine might reveal a genetic defect which is theoretically a target for pharmacological therapy, for example by antifolic drugs. Copyright © 2005 S. Karger AG.

Published
2005

10. Su storia e discorso in hegel

Author

Amori, M, Bianchi, G, Bonicalzi, F, Cevasco, P, Costa, V, Facioni, S, Longobardi, R, Maletta, S, Manfreda, L, Matrangolo, S, Maurizi, M, Muscherà, B, Palombi, F, Rizzo, E, and Vigorelli, I

Subjects
Storia linguaggio soggettività, Settore M-FIL/01 - Filosofia Teoretica
Published
2014

18. Selective, Energy-dependent Proteolysis in Escherichia coli

Author

Jubete Y, Singh Sk, Susan Gottesman, Kessel M, Wickner S, and Maurizi M

Subjects
DNA, Bacterial, Energy dependent, Proteolysis, Molecular Sequence Data, medicine.disease_cause, Biochemistry, Substrate Specificity, Adenosine Triphosphate, ATP-Dependent Proteases, Endopeptidases, Escherichia coli, Genetics, medicine, Humans, Amino Acid Sequence, Molecular Biology, Heat-Shock Proteins, Adenosine Triphosphatases, Molecular Structure, Sequence Homology, Amino Acid, medicine.diagnostic_test, Chemistry, Serine Endopeptidases, Endopeptidase Clp, Energy Metabolism, Molecular Chaperones
Published
1995

19. A multicenter trial of specific local nasal immunotherapy

Author

Motta, G., Passali, D., Vincentiis, I., Ottaviani, A., Maurizi, M., Sartoris, A., Pallestrini, E., sergio motta, Salzano, F. A., Motta, Gaetano, Passali, D, De Vincentiis, I, Ottaviani, A, Maurizi, M, Sartoris, A, Pallestrini, E, Motta, S, and Salzano, Fa

Subjects
Adult, Male, Mites, Nasal Provocation Tests, Rhinitis, Allergic, Perennial, Adolescent, Dose-Response Relationship, Immunologic, Middle Aged, Double-Blind Method, Animals, Humans, Pollen, Female, Immunotherapy, Child, Administration, Intranasal, Skin Tests
Abstract

To assess the efficacy and safety of specific local nasal immunotherapy (LNIT) in powder form in patients with allergic rhinitis, using subjective and objective parameters.A double-blind randomized multicenter trial of 102 patients with allergic rhinitis who were treated with specific LNIT for 8 consecutive months.After identifying allergens with the skin prick test and sensitization threshold dose with the specific nasal provocation test, 102 patients were selected, of whom 55 were allergic to mites and 47 were allergic to Graminaceae or Parietaria pollen. The specific treatments were self-administered using an insufflator in two phases (phase 1: increasing doses; phase: 2, maintenance dose). Patients were evaluated before and after 32 weeks of treatment by subjective analysis of their self-reported symptoms and by objective analysis of nasal provocation test, nasal resistance by anterior rhinomanometry, and mucociliary clearance time.Clinical efficacy of LNIT for allergy to mites and pollens was confirmed by the differences in the symptoms score between the active group and the placebo group. The nasal provocation test results confirmed that this difference was statistically significant. The rhinomanometric analysis gave positive results for the treated group mainly in LNIT for mites. No differences in mucociliary clearance time were found.Specific LNIT is effective for allergic rhinitis and appears to offer considerable advantages over other hyposensitization methods. It can be done at home, patient compliance is good, and the treatment is safe.

Published
2000

24. VEMPs and dynamic posturography after intratympanic gentamycin in Menière's disease

Author

Picciotti, P. M., Fiorita, A., Di Nardo, W., Nicola Quaranta, Paludetti, G., and Maurizi, M.

Subjects
Adult, Male, Ménière’s disease, Tympanic Membrane, Posture, dynamic posturogrphy, Middle Aged, VEMPs, Evoked Potentials, Auditory, Vertigo, Humans, Female, Settore MED/31 - OTORINOLARINGOIATRIA, Vestibule, Labyrinth, Gentamicins, VEMPs, dynamic posturogrphy, Postural Balance, Meniere Disease, Aged
Abstract

In this study, we investigated whether vestibular evoked myogenic potentials (VEMPs) and dynamic posturography (DP) are useful in the evaluation of the vestibular function in patients affected by active monoaural Menière's disease (MD) treated with intratympanic gentamycin. Twelve subjects affected by monoaural MD were treated with weekly intratympanic injections of 0.5 ml of gentamycin at a concentration of 20 mg/ml. VEMPs were used to test saccular function, while postural control was analyzed by DP. The results obtained with these two techniques were compared with those obtained by using bithermal caloric test. The mean follow-up was 15.3 months (6--28 months). Therapy resulted in complete absence of the caloric response in six subjects (50) and in caloric test-induced asymmetry in the remaining individuals, ranging from 83 to 27. At follow-up, eleven patients (91.6%) were free of vertigo, while one patient had two vertigo spells 9 months after treatment. Before treatment, VEMPs were present in the affected ear of eleven patients. After treatment VEMPs were absent in all the patients. At the end of follow-up, reappearance of VEMPs was observed in two patients, with no changes in latency values and amplitude ratio. DP demonstrated a reduction of the Composite Score (CS) one week after therapy, with a prevalent reduction of the vestibular component. After 6 months, there was an improvement of the CS and, in particular, of the vestibular component. The present study demonstrates that bithermal caloric test and VEMPs allow for the functional evaluation of both the horizontal semicircular canal and the sacculus, suggesting that these techniques might be used together to monitor the efficacy of intratympanic gentamycin therapy. In addition, our data indicate that DP might provide important information on compensation phenomena and show that intratympanic gentamycin can improve postural control in MD patients.

Published
2005

26. Ras p21, EGFR and human papillomavirus in laryngeal cancer

Author

Maurizi, M, Almadori, G, Paludetti, G, Cadoni, G, Ottaviani, F, Rosignoli, M, Ferrandina, G, Scambia, G, Cattani, P, Posteraro, P, Catozzi, L, and Piffanelli, A

Subjects
Settore MED/31 - Otorinolaringoiatria
Published
2003

29. AUDIOVESTIBOLOGIA CLINICA

Author

Maurizi, M, Simoncelli, C, Frenguelli, A, Rosignoli, M, Paludetti, G, and Ottaviani, F

Subjects
Settore MED/31 - Otorinolaringoiatria, Settore MED/32 - Audiologia
Published
2000

48. VEMPs and dynamic posturography after intratympanic gentamycin in Menière's disease

Author

Picciotti, Pasqualina Maria, Fiorita, Antonella, Di Nardo, Walter, Quaranta, N., Paludetti, Gaetano, Maurizi, Maurizio, Picciotti P. M. (ORCID:0000-0002-1502-6508), Fiorita A., Di Nardo W. (ORCID:0000-0001-5058-6431), Paludetti G. (ORCID:0000-0003-2480-1243), Maurizi M., Picciotti, Pasqualina Maria, Fiorita, Antonella, Di Nardo, Walter, Quaranta, N., Paludetti, Gaetano, Maurizi, Maurizio, Picciotti P. M. (ORCID:0000-0002-1502-6508), Fiorita A., Di Nardo W. (ORCID:0000-0001-5058-6431), Paludetti G. (ORCID:0000-0003-2480-1243), and Maurizi M.

Abstract

In this study, we investigated whether vestibular evoked myogenic potentials (VEMPs) and dynamic posturography (DP) are useful in the evaluation of the vestibular function in patients affected by active monoaural Menière's disease (MD) treated with intratympanic gentamycin. Twelve subjects affected by monoaural MD were treated with weekly intratympanic injections of 0.5 ml of gentamycin at a concentration of 20 mg/ml. VEMPs were used to test saccular function, while postural control was analyzed by DP. The results obtained with these two techniques were compared with those obtained by using bithermal caloric test. The mean follow-up was 15.3 months (6--28 months). Therapy resulted in complete absence of the caloric response in six subjects (50) and in caloric test-induced asymmetry in the remaining individuals, ranging from 83 to 27. At follow-up, eleven patients (91.6%) were free of vertigo, while one patient had two vertigo spells 9 months after treatment. Before treatment, VEMPs were present in the affected ear of eleven patients. After treatment VEMPs were absent in all the patients. At the end of follow-up, reappearance of VEMPs was observed in two patients, with no changes in latency values and amplitude ratio. DP demonstrated a reduction of the Composite Score (CS) one week after therapy, with a prevalent reduction of the vestibular component. After 6 months, there was an improvement of the CS and, in particular, of the vestibular component. The present study demonstrates that bithermal caloric test and VEMPs allow for the functional evaluation of both the horizontal semicircular canal and the sacculus, suggesting that these techniques might be used together to monitor the efficacy of intratympanic gentamycin therapy. In addition, our data indicate that DP might provide important information on compensation phenomena and show that intratympanic gentamycin can improve postural control in MD patients.

Published
2005

49. Oncogenesi e cancro della laringe

Author

Almadori, G, Cadoni, G, Maurizi, M, Ottaviani, F, Paludetti, G, Cattani, P, and Scambia, G

Subjects
Settore MED/31 - Otorinolaringoiatria, Settore MED/06 - Oncologia Medica
Published
1995

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