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1. Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities

Author

Hans J.C.T. Wessels, Purva Kulkarni, Maurice van Dael, Anouk Suppers, Esther Willems, Fokje Zijlstra, Else Kragt, Jolein Gloerich, Pierre-Olivier Schmit, Stuart Pengelley, Kristina Marx, Alain J. van Gool, and Dirk J. Lefeber

Subjects
Glycosylation, Glycoproteomics, Blood plasma, Congenital disorders of glycosylation, Clinical applications, Medicine (General), R5-920, Science (General), Q1-390
Abstract

Introduction: The human plasma glycoproteome holds enormous potential to identify personalized biomarkers for diagnostics. Glycoproteomics has matured into a technology for plasma N-glycoproteome analysis but further evolution towards clinical applications depends on the clinical validity and understanding of protein- and site-specific glycosylation changes in disease. Objectives: Here, we exploited the uniqueness of a patient cohort of genetic defects in well-defined glycosylation pathways to assess the clinical applicability of plasma N-glycoproteomics. Methods: Comparative glycoproteomics was performed of blood plasma from 40 controls and 74 patients with 13 different genetic diseases that impact the protein N-glycosylation pathway. Baseline glycosylation in healthy individuals was compared to reference glycome and intact transferrin protein mass spectrometry data. Use of glycoproteomics data for biomarker discovery and sample stratification was evaluated by multivariate chemometrics and supervised machine learning. Clinical relevance of site-specific glycosylation changes were evaluated in the context of genetic defects that lead to distinct accumulation or loss of specific glycans. Integrated analysis of site-specific glycoproteome changes in disease was performed using chord diagrams and correlated with intact transferrin protein mass spectrometry data. Results: Glycoproteomics identified 191 unique glycoforms from 58 unique peptide sequences of 34 plasma glycoproteins that span over 3 magnitudes of abundance in plasma. Chemometrics identified high-specificity biomarker signatures for each of the individual genetic defects with better stratification performance than the current diagnostic standard method. Bioinformatic analyses revealed site-specific glycosylation differences that could be explained by underlying glycobiology and protein-intrinsic factors. Conclusion: Our work illustrates the strong potential of plasma glycoproteomics to significantly increase specificity of glycoprotein biomarkers with direct insights in site-specific glycosylation changes to better understand the glycobiological mechanisms underlying human disease.

Published
2024
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2. Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens

Author

Esther Willems, Jolein Gloerich, Anouk Suppers, Michiel van der Flier, Lambert P. van den Heuvel, Nicole van de Kar, Ria H.L.A. Philipsen, Maurice van Dael, Myrsini Kaforou, Victoria J. Wright, Jethro A. Herberg, Federico Martinon Torres, Michael Levin, Ronald de Groot, Alain J. van Gool, Dirk J. Lefeber, Hans J.C.T. Wessels, Marien I. de Jonge, Amina Abdulla, Christoph Aebi, Koen van Aerde, Rachel Agbeko, Philipp Agyeman, Umberto D’alessandro, Ladan Ali, Wynand Alkema, Karen Allen, Fernando Álvez González, Suzanne Anderson, Imran Ansari, Tasnim Araf, Tanja Avramoska, Bryan Baas, Natalija Bahovec, Cristina Balo Farto, Anda Balode, A.M. Barendregt, Ruth Barral-Arca, María Barreiro Castro, Arta Bārzdiņa, David Bath, Sebastian Bauchinger, Lucas Baumard, Hinrich Baumgart, Frances Baxter, Ashley Bell, Kathryn Bell, Xabier Bello, Evangelos Bellos, Martin Benesch, Mirian Ben García, Joshua Bennet, Christoph Berger, J.M. van den Berg, Sara Bernhard-Stirnemann, Sagida Bibi, Christoph Bidlingmaier, Alexander Binder, Vera Binder, Kalifa Bojang, Dorine M. Borensztajn, Ulrich von Both, Karen Brengel-Pesce, Bryan van den Broek, Judith Buschbeck, Leo Calvo-Bado, Sandra Carnota, Enitan D. Carrol, Michael J. Carter, Miriam Cebey-López, Samba Ceesay, Astrid Ceolotto, Adora Chan, Elizabeth Cocklin, Kalvin Collings, Stephen Crulley, Aubrey Cunnington, María José Curras-Tuala, Katharina Danhauser, Saffiatou Darboe, Sarah Darnell, Tisham De, Dārta Deksne, Kirsty Devine, Juan Emmanuel Dewez, Julia Dudley, Carlos Durán Suárez, Ernst Eber, Irini Eleftheriou, Marieke Emonts, Daniel Fabian, Tobias Feuchtinger, Katy Fidler, Colin Fink, A.M. van Furth, Rachel Galassini, Siegfried Gallistl, Luisa García Vicente, Dace Gardovska, J. Geissler, G.P.J.M. Gerrits, Eric Giannoni, Ilona van der Giessen, Alberto Gómez-Carballa, Jose Gómez Rial, Gunther Gores, Dagne Grāvele, Matthias Griese, Ilze Grope, Meeru Gurung, L. de Haan, Nikolaus Haas, Dominic Habgood-Coote, Nienke N. Hagedoorn, Harald Haidl, Shea Hamilton, Almuthe Hauer, J. Heidema, Ulrich Heininger, Stefanie Henriet, Jethro Herberg, Clive Hoggart, Susanne Hösele, Sara Hourmat, Christa Hude, Martijn Huijnen, Heather Jackson, Rebecca Jennings, Joanne Johnston, Ilse Jongerius, Rikke Jorgensen, Christian Kahlert, Rama Kandasamy, Matthias Kappler, Julia Keil, Markus Keldorfer, Dominic F. Kell, Eunjung Kim, Sharon King, Lieke Kloosterhuis, Daniela S. Kohlfürst, Benno Kohlmaier, Laura Kolberg, Mojca Kolnik, Larissa Krenn, Taco Kuijpers, M. van der Kuip, Pilar Leboráns Iglesias, Simon Leigh, Manuel Leitner, M. van Leur, Emma Lim, Naomi Lin, Ching-Chuan Liu, Sabine Löffler, Eberhard Lurz, Ian Maconochie, Christine Mackerness, François Mallet, Federico Martinón-Torres, Antonis Marmarinos, Alex Martin, Mike Martin, José María Martinón Sánchez, Nazareth Martinón-Torres, Paul McAlinden, Anne McDonnell, Sam McDonald, C.J. Miedema, Anija Meiere, Stephanie Menikou, G. van Mierlo, Alec Miners, Ravi Mistry, Henriëtte A. Moll, Marine Mommert, Belén Mosquera Pérez, David R. Murdoch, Sobia Mustafa, Giancarlo Natalucci, C. Neeleman, Karen Newall, Samuel Nichols, Tobias Niedrist, Anita Niederer-Loher, Ruud Nijman, Ieva Nokalna, Urzula Nora Urbāne, Gudrun Nordberg, C.C. Obihara, Daniel O'Connor, Wilma Oosthoek, Veronika Osterman, Alexandre Pachot, D. Pajkrt, Jacobo Pardo-Seco, Stéphane Paulus, Jana Pavāre, Ivonne Pena Paz, Salina Persand, Andreas Pfleger, Klaus Pfurtscheller, Ria Philipsen, Ailsa Pickering, Benjamin Pierce, Heidemarie Pilch, Lidia Piñeiro Rodríguez, Sara Pischedda, Tina Plankar Srovin, Marko Pokorn, Andrew J. Pollard, Lena Pölz, Klara M. Posfay-Barbe, Petra Prunk, Zanda Pučuka, Glorija Rajic, Aqeela Rashid, Lorenzo Redondo-Collazo, Christa Relly, Irene Rivero Calle, Sara Rey Vázquez, Mathew Rhodes, Vivien Richmond, Thomas Riedel, Anna RocaIsatou Sarr, Siegfried Rödl, Carmen Rodríguez-Tenreiro, Sam Romaine, Emily Rowlands, Miguel Sadiki Ora, Manfred G. Sagmeister, Momodou Saidykhan, Antonio Salas, Luregn J. Schlapbach, D. Schonenberg, Fatou Secka, Katrīna Selecka, Sonia Serén Fernández, Cristina Serén Trasorras, Priyen Shah, Ching-Fen Shen, Shrijana Shrestha, Aleksandra Sidorova, Andrea Skrabl-Baumgartner, Giselle D’Souza, Matthias Sperl, Evelien Sprenkeler, Nina A. Schweintzger, Laura Stampfer, Molly Stevens, Martin Stocker, Volker Strenger, Dace Svile, Kelly Syggelou, Maria Tambouratzi, Chantal Tan, Emma Tavliavini, Evelyn Thomson, Stephen Thorson, Holger Till, G.A. Tramper-Stranders, Andreas Trobisch, Maria Tsolia, Effua Usuf, Lucille Valentine, Clementien L. Vermont, Marisol Vilas Iglesias, Katarina Vincek, Marie Voice, Gabriella de Vries, Diane Wallia, Shih-Min Wang, Clare Wilson, Amanda Wood, Phil Woodsford, Victoria Wright, Marietta Xagorari, Shunmay Yeung, Joany Zachariasse, Dace Zavadska, Syed M.A. Zaman, Judith Zandstra, Werner Zenz, Christoph Zurl, and Manuela Zwerenz

Subjects
Health sciences, Glycobiology, Immunology, Glycomics, Science
Abstract

Summary: Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response to infection. The protein site-specific glycosylation was characterized in plasma derived from well-defined controls and patients. We found 3862 unique features, of which we identified 463 distinct intact glycopeptides, that could be mapped to more than 30 different proteins. Statistical analyses were used to derive a glycopeptide signature that enabled significant differentiation between patients with a bacterial or viral infection. Furthermore, supported by a machine learning algorithm, we demonstrated the ability to identify the causative pathogens based on the distinctive host blood plasma glycopeptide signatures. These results illustrate that glycoproteomics holds enormous potential as an innovative approach to improve the interpretation of relevant biological changes in response to infection.

Published
2023
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3. Collection of human and environmental data on pesticide use in Europe and Argentina: Field study protocol for the SPRINT project

Author

Vera Silva, Abdallah Alaoui, Vivi Schlünssen, Anne Vested, Martien Graumans, Maurice van Dael, Marco Trevisan, Nicoleta Suciu, Hans Mol, Karsten Beekmann, Daniel Figueiredo, Paula Harkes, Jakub Hofman, Ellen Kandeler, Nelson Abrantes, Isabel Campos, María Ángeles Martínez, Joana Luísa Pereira, Dirk Goossens, Juergen Gandrass, Freya Debler, Esperanza Huerta Lwanga, Marlot Jonker, Frank van Langevelde, Martin T. Sorensen, Jerry M. Wells, Jos Boekhorst, Anke Huss, Daniele Mandrioli, Daria Sgargi, Paul Nathanail, Judith Nathanail, Lucius Tamm, Peter Fantke, Jennifer Mark, Christian Grovermann, Ana Frelih-Larsen, Irina Herb, Charlotte-Anne Chivers, Jane Mills, Francisco Alcon, Josefina Contreras, Isabelle Baldi, Igor Pasković, Glavan Matjaz, Trine Norgaard, Virginia Aparicio, Coen J. Ritsema, Violette Geissen, and Paul T. J. Scheepers

Subjects
Medicine, Science
Abstract

Current farm systems rely on the use of Plant Protection Products (PPP) to secure high productivity and control threats to the quality of the crops. However, PPP use may have considerable impacts on human health and the environment. A study protocol is presented aiming to determine the occurrence and levels of PPP residues in plants (crops), animals (livestock), humans and other non-target species (ecosystem representatives) for exposure modelling and impact assessment. To achieve this, we designed a cross-sectional study to compare conventional and organic farm systems across Europe. Environmental and biological samples were/are being/will be collected during the 2021 growing season, at 10 case study sites in Europe covering a range of climate zones and crops. An additional study site in Argentina will inform the impact of PPP use on growing soybean which is an important European protein-source in animal feed. We will study the impact of PPP mixtures using an integrated risk assessment methodology. The fate of PPP in environmental media (soil, water and air) and in the homes of farmers will be monitored. This will be complemented by biomonitoring to estimate PPP uptake by humans and farm animals (cow, goat, sheep and chicken), and by collection of samples from non-target species (earthworms, fish, aquatic and terrestrial macroinvertebrates, bats, and farm cats). We will use data on PPP residues in environmental and biological matrices to estimate exposures by modelling. These exposure estimates together with health and toxicity data will be used to predict the impact of PPP use on environment, plant, animal and human health. The outcome of this study will then be integrated with socio-economic information leading to an overall assessment used to identify transition pathways towards more sustainable plant protection and inform decision makers, practitioners and other stakeholders regarding farming practices and land use policy.

Published
2021

4. Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities

Author

Hans JCT Wessels, Purva Kulkarni, Maurice van Dael, Anouk Suppers, Esther Willems, Fokje Zijlstra, Else Kragt, Jolein Gloerich, Pierre-Olivier Schmit, Stuart Pengelley, Kristina Marx, Alain J van Gool, and Dirk J Lefeber

Abstract

The human plasma glycoproteome holds enormous potential to identify personalized biomarkers to diagnose and understand disease. Recent advances in mass spectrometry and software development are opening novel avenues to mine the glycoproteome for protein- and site-specific glycosylation changes. Here, we describe a novel plasma N-glycoproteomics method for disease diagnosis and evaluated its clinical applicability by performing comparative glycoproteomics in blood plasma of 40 controls and a cohort of 74 patients with 13 different genetic diseases that directly impact the protein N-glycosylation pathway. The plasma glycoproteome yielded high-specificity biomarker signatures for each of the individual genetic defects. Bioinformatic analyses revealed site-specific glycosylation differences that could be explained by underlying glycobiology and in specific diseases by protein-intrinsic factors. Our work illustrates the strong potential of plasma glycoproteomics to significantly increase specificity of glycoprotein biomarkers with direct insights in site-specific glycosylation changes to better understand the mechanisms underlying human disease.

Published
2022
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5. Reply to Viner, A.; Ayrey, S. Comment on 'Scheepers et al. Comparative Performance Testing of Respirator versus Surgical Mask Using a Water Droplet Spray Model. Int. J. Environ. Res. Public Health 2021, 18, 1599'

Author

Paul T. J. Scheepers, Heiman F. L. Wertheim, Maurice van Dael, Rob Anzion, Henk Jan Holterman, Steven Teerenstra, Martijn de Groot, Andreas Voss, and Joost Hopman

Subjects
lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Ventilators, Mechanical, Health, Toxicology and Mutagenesis, Ventilators, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Public Health, Environmental and Occupational Health, Life Science, Water, Public Health, Mechanical, Agro Field Technology Innovations, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract

Contains fulltext : 251201.pdf (Publisher’s version ) (Open Access) The response to our publication by Andrew Viner and Stewart Ayrey is much appreciated [...].

Published
2022

6. HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Author

Kate Jones, Elizabeth Leese, Beatrice Bocca, Ovnair Sepai, Piero Lovreglio, Henna Veijalainen, Emilie Hardy, Flavien Denis, Paul T.J. Scheepers, Susana Viegas, Hermínia Pinhal, Tiina Santonen, Davy Rousset, Angela Gambelunghe, Veruscka Leso, Sílvia Reis Santos, Bruno Gomes, Ivo Iavicoli, Mohamed Rizki, Flavia Ruggieri, Andrea Cattaneo, Carina Ladeira, Lode Godderis, Ana Nogueira, Wojciech Wasowicz, Guillaume Antoine, Robert Spoek, Manuella Burgart, Radu Corneliu Duca, An Van Nieuwenhuyse, Mathieu Melczer, Simo P. Porras, Maurice van Dael, Giuseppe De Palma, Domenico Maria Cavallo, Riikka Helenius, Jouko Remes, Edna Ribeiro, Katrien Poels, Sophie Ndaw, Kukka Aimonen, Elisabeta Pletea, Ogier Hanser, Françoise Schaefers, Maria João Silva, Sally Spankie, Thomas Göen, Radia Bousoumah, Henriqueta Louro, Rob B. M. Anzion, Marta Esteban López, Argelia Castaño, Philippe Marsan, Nicole Majery, Karen S. Galea, Jelle Verdonck, Beata Janasik, Unión Europea. Comisión Europea. H2020, Santonen, T., Porras, S. P., Bocca, B., Bousoumah, R., Duca, R. C., Galea, K. S., Godderis, L., Goen, T., Hardy, E., Iavicoli, I., Janasik, B., Jones, K., Leese, E., Leso, V., Louro, H., Majery, N., Ndaw, S., Pinhal, H., Ruggieri, F., Silva, M. J., van Nieuwenhuyse, A., Verdonck, J., Viegas, S., Wasowicz, W., Sepai, O., Scheepers, P. T. J., Aimonen, K., Antoine, G., Anzion, R., Burgart, M., Castano, A., Cattaneo, A., Cavallo, D. M., De Palma, G., Denis, F., Gambelunghe, A., Gomes, B., Hanser, O., Helenius, R., Ladeira, C., Lopez, M. E., Lovreglio, P., Marsan, P., Melczer, M., Nogueira, A., Pletea, E., Poels, K., Remes, J., Ribeiro, E., Santos, S. R., Schaefers, F., Spankie, S., Spoek, R., Rizki, M., Rousset, D., van Dael, M., and Veijalainen, H.

Subjects
Chromium, chemistry.chemical_element, Air Pollutants, Occupational, 010501 environmental sciences, Hexavalent chromium, 01 natural sciences, Biochemistry, Dermal exposure, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Urinary levels, Plating, Occupational Exposure, Biomonitoring, Chromates, Humans, Exhaled breath condensate, Welding, Electroplating, Occupational exposure, Chromium (VI), 0105 earth and related environmental sciences, General Environmental Science, Biomarkers of Exposure, Air Pollutants, Other Research Radboud Institute for Health Sciences [Radboudumc 0], 030210 environmental & occupational health, Occupational, Cross-Sectional Studies, chemistry, Environmental chemistry, Genotoxicidade Ambiental, Environmental Health, Biological Monitoring, Environmental Monitoring
Abstract

Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals. This work has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author's organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means. Sí

Published
2021

7. Comparative Performance Testing of Respirator versus Surgical Mask Using a Water Droplet Spray Model

Author

Joost Hopman, Andreas Voss, Martijn de Groot, Heiman F. L. Wertheim, Rob B. M. Anzion, Paul T.J. Scheepers, Steven Teerenstra, H.J. Holterman, and Maurice van Dael

Subjects
Face shield, Materials science, business.product_category, Infectious Disease Transmission, Patient-to-Professional, Coronavirus disease 2019 (COVID-19), Health, Toxicology and Mutagenesis, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), lcsh:Medicine, COVID-19 pandemic, Economic shortage, Article, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], respiratory protective equipment, Virus transmission, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Occupational Exposure, Humans, 030212 general & internal medicine, particle size distribution, Respirator, Respiratory Protective Devices, Agro Field Technology Innovations, Personal Protective Equipment, Aerosols, 0303 health sciences, Ventilators, Mechanical, 030306 microbiology, SARS-CoV-2, Other Research Radboud Institute for Health Sciences [Radboudumc 0], lcsh:R, Public Health, Environmental and Occupational Health, Respiratory protective equipment, Masks, COVID-19, Water, Test method, virus transmission, Particle size distribution, Nebulizer, Surgical mask, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], business, Biomedical engineering
Abstract

Background During the SARS-CoV-2 pandemic, there was shortage of the standard respiratory protective equipment (RPE). The aim of this study was to develop a procedure to test the performance of alternative RPEs used in the care of COVID-19 patients. Methods A laboratory-based test was developed to compare RPEs by total inward leakage (TIL). We used a crossflow nebulizer to produce a jet spray of 1–100 µm water droplets with a fluorescent marker. The RPEs were placed on a dummy head and sprayed at distances of 30 and 60 cm. The outcome was determined as the recovery of the fluorescent marker on a membrane filter placed on the mouth of the dummy head. Results At 30 cm, a type IIR surgical mask gave a 17.7% lower TIL compared with an FFP2 respirator. At 60 cm, this difference was similar, with a 21.7% lower TIL for the surgical mask compared to the respirator. When adding a face shield, the TIL at 30 cm was further reduced by 9.5% for the respirator and 16.6% in the case of the surgical mask. Conclusions A safe, fast and very sensitive test method was developed to assess the effectiveness of RPE by comparison under controlled conditions.

Published
2021

8. Thermal plasma activation and UV/H(2)O(2) oxidative degradation of pharmaceutical residues

Author

Martien H.F. Graumans, Maurice van Dael, Rob B. M. Anzion, Paul T.J. Scheepers, Frans G. M. Russel, Wilfred F.L.M. Hoeben, Electrical Energy Systems, EIRES Chem. for Sustainable Energy Systems, and Power Conversion

Subjects
Medicine residues, Sewage, 010501 environmental sciences, 01 natural sciences, Biochemistry, Ziekenhuis rioolwater, Complexe water matrices, 03 medical and health sciences, 0302 clinical medicine, Tap water, Liquid chromatography–mass spectrometry, 030212 general & internal medicine, 0105 earth and related environmental sciences, General Environmental Science, Complex water matrices, business.industry, Chemistry, Hospital sewage water, Plasma activation, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Advanced oxidation processes, Contamination, Biodegradation, Onsite sewage facility, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Geavanceerde oxidatie technologie, Environmental chemistry, Medicijnresten, Sewage treatment, business
Abstract

Oxidatieve degradatie van medicijnresten in rioolwater met behulp van thermisch plasma en UV-H2O2 technologie., The aquatic environment becomes increasingly contaminated by anthropogenic pollutants such as pharmaceutical residues. Due to poor biodegradation and continuous discharge of persistent compounds in sewage water samples, pharmaceutical residues might end up in surface waters when not removed. To minimize this pollution, onsite wastewater treatment techniques might complement conventional waste water treatment plants (WWTPs). Advanced oxidation processes are useful techniques, since reactive oxygen species (ROS) are used for the degradation of unwanted medicine residues. In this paper we have studied the advanced oxidation in a controlled laboratory setting using thermal plasma and UV/H2O2 treatment. Five different matrices, Milli-Q water, tap water, synthetic urine, diluted urine and synthetic sewage water were spiked with 14 pharmaceuticals with a concentration of 5 μg/L. All compounds were reduced or completely decomposed by both 150 W thermal plasma and UV/H2O2 treatment. Additionally, also hospital sewage water was tested. First the concentrations of 10 pharmaceutical residues were determined by liquid chromatography mass spectrometry (LC-MS/MS). The pharmaceutical concentration ranged from 0.08 up to 2400 μg/L. With the application of 150 W thermal plasma or UV/H2O2, it was found that overall pharmaceutical degradation in hospital sewage water were nearly equivalent to the results obtained in the synthetic sewage water. However, based on the chemical abatement kinetics it was demonstrated that the degree of degradation decreases with increasing matrix complexity. Since reactive oxygen and nitrogen species (RONS) are continuously produced, thermal plasma treatment has the advantage over UV/H2O2 treatment.

Published
2021

9. Collection of human and environmental data on pesticide use in Europe and Argentina : Field study protocol for the SPRINT project

Author

Igor Pasković, Juergen Gandrass, Daniele Mandrioli, Esperanza Huerta Lwanga, Josefina Contreras, Lucius Tamm, Martin Tang Sørensen, Jos Boekhorst, Abdallah Alaoui, Dirk Goossens, Virginia Aparicio, Freya Debler, Joana Luísa Pereira, Jakub Hofman, Judith Nathanail, Nicoleta Suciu, María Ángeles Martínez, Christian Grovermann, Paula Harkes, Ellen Kandeler, Irina Herb, Isabelle Baldi, Marco Trevisan, Francisco Alcon, Anke Huss, Glavan Matjaz, Vivi Schlünssen, Vera M. F. da Silva, Jane Mills, C. Paul Nathanail, Martien H.F. Graumans, Anne Vested, Isabel Campos, Hans G.J. Mol, Charlotte-Anne Chivers, Coen J. Ritsema, Jennifer Mark, Frank van Langevelde, Marlot Jonker, Nelson Abrantes, Violette Geissen, Karsten Beekmann, Paul T.J. Scheepers, Peter Fantke, Trine Norgaard, Maurice van Dael, Daria Sgargi, Daniel Martins Figueiredo, Jerry M. Wells, Ana Frelih-Larsen, Silva, Vera [0000-0002-9511-6588], Schlünssen, Vivi [0000-0003-4915-1734], Graumans, Martien [0000-0002-3003-6632], Suciu, Nicoleta [0000-0002-3183-4169], Harkes, Paula [0000-0003-3347-9698], Martínez, María Ángeles [0000-0002-3927-3183], Pereira, Joana Luísa [0000-0001-7573-6184], Debler, Freya [0000-0002-2385-2199], van Langevelde, Frank [0000-0001-8870-0797], Sgargi, Daria [0000-0003-3829-7957], Tamm, Lucius [0000-0003-3725-9406], Fantke, Peter [0000-0001-7148-6982], Chivers, Charlotte-Anne [0000-0003-3267-5558], Pasković, Igor [0000-0002-3937-3926], Apollo - University of Cambridge Repository, Wageningen University and Research [Wageningen] (WUR), University of Bern, Aarhus University [Aarhus], National Research Centre for the Working Environment (NRCWE), Radboud Institute for Health Sciences [Nimègue, Pays-Bas], Radboud University Medical Center [Nijmegen], Università cattolica del Sacro Cuore [Piacenza e Cremona] (Unicatt), Utrecht University [Utrecht], Masaryk University [Brno] (MUNI), University of Hohenheim, Centre for Environmental and Marine Studies [Aveiro] (CESAM), Universidade de Aveiro, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Helmholtz-Zentrum Hereon, Research Institute of Organic Agriculture - Forschungsinstitut für biologischen Landbau (FiBL), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), ECOLOGIC INSTITUTE BERLIN DEU, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), University of Gloucestershire (Cheltenham, GB), Universidad de Cartagena [Cartagena de Indias], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cancer environnement (EPICENE ), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Agriculture and Tourism, University of Ljubljana, Instituto Nacional de Tecnología Agropecuaria (INTA), Radboud Institute for Health Sciences [Nijmegen, the Netherlands], and European Project: 825619,AI4EU

Subjects
010504 meteorology & atmospheric sciences, S605.5_Organic, UNCERTAINTY, Biochemistry, 01 natural sciences, Study Protocol, Agricultural Soil Science, SDG 13 - Climate Action, 910 Geography & travel, SDG 15 - Life on Land, Environmental resource management, Geology, Genomics, PE&RC, 6. Clean water, Medical Microbiology, Science & Technology - Other Topics, Medicine, Livestock, Agrochemicals, Crops, Agricultural, S1, Farms, Science, Crop health, quality, protection, Argentina, Soil Science, Growing season, Team Toxicology, Microbial Genomics, Environment, S589.75_Agriculture, Microbiology, 12. Responsible consumption, SDG 3 - Good Health and Well-being, Settore AGR/13 - CHIMICA AGRARIA, Genetics, Humans, SF, Ecosystem, Host-Microbe Interactomics, Pesticides, 550 Earth sciences & geology, Petrology, VLAG, Agricultural, Science & Technology, Biology and Life Sciences, 15. Life on land, Bodemfysica en Landbeheer, Team Pesticides 2, Medio Ambiente, SB599_Pests, Agriculture, Research Proyects, RESIDUES, WIAS, Pest Control, Microbiome, Biomarkers, Plaguicidas, 010501 environmental sciences, Environmental data, AGRICULTURAL SOILS, Animal Management, RISK, Sedimentary Geology, 2. Zero hunger, Multidisciplinary, Data Collection, Collección de Datos, Multidisciplinary Sciences, Europe, Organic farming, Europa, Risk assessment, CHROMATOGRAPHY, Crops, S589.7_Agricultural, Life Science, Animals, EXPOSURE, General, 0105 earth and related environmental sciences, Proyectos de Investigación, WIMEK, business.industry, Impact assessment, Soil Physics and Land Management, 13. Climate action, Wildlife Ecology and Conservation, Earth Sciences, Environmental science, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Sediment, business, Crop Science
Abstract

Current farm systems rely on the use of Plant Protection Products (PPP) to secure high productivity and control threats to the quality of the crops. However, PPP use may have considerable impacts on human health and the environment. A study protocol is presented aiming to determine the occurrence and levels of PPP residues in plants (crops), animals (livestock), humans and other non-target species (ecosystem representatives) for exposure modelling and impact assessment. To achieve this, we designed a cross-sectional study to compare conventional and organic farm systems across Europe. Environmental and biological samples were/are being/will be collected during the 2021 growing season, at 10 case study sites in Europe covering a range of climate zones and crops. An additional study site in Argentina will inform the impact of PPP use on growing soybean which is an important European protein-source in animal feed. We will study the impact of PPP mixtures using an integrated risk assessment methodology. The fate of PPP in environmental media (soil, water and air) and in the homes of farmers will be monitored. This will be complemented by biomonitoring to estimate PPP uptake by humans and farm animals (cow, goat, sheep and chicken), and by collection of samples from non-target species (earthworms, fish, aquatic and terrestrial macroinvertebrates, bats, and farm cats). We will use data on PPP residues in environmental and biological matrices to estimate exposures by modelling. These exposure estimates together with health and toxicity data will be used to predict the impact of PPP use on environment, plant, animal and human health. The outcome of this study will then be integrated with socio-economic information leading to an overall assessment used to identify transition pathways towards more sustainable plant protection and inform decision makers, practitioners and other stakeholders regarding farming practices and land use policy. EEA Balcarce Fil: Silva, Vera. Wageningen University and Research. Soil Physics and Land Management Group; Países Bajos. Fil: Alaoui, Abdallah. University of Bern. Institute of Geography. Centre for Development and Environment; Suiza. Fil: Schlünssen, Vivi. Aarhus University. Department of Public Health; Dinamarca. National Research Centre for the Working Environment; Dinamarca. Fil: Vested, Anne. Aarhus University. Department of Public Health; Dinamarca. Fil: Graumans, Martien. Radboud Institute for Health Sciences; Países Bajos. Fil: Van Dael, Maurice. Radboud Institute for Health Sciences; Países Bajos. Fil: Trevisan, Marco. Università Cattolica del Sacro Cuore. Department for Sustainable Food Process; Italia. Fil: Suciu, Nicoleta. Università Cattolica del Sacro Cuore. Department for Sustainable Food Process; Italia. Fil: Mol, Hans. Wageningen University and Research. Wageningen Food Safety Research; Países Bajos. Fil: Beekmann, Karsten. Wageningen University and Research. Wageningen Food Safety Research; Países Bajos. Fil: Figueiredo, Daniel. Utrecht University. Institute for Risk Assessment Sciences; Países Bajos. Fil: Harkes, Paula. Wageningen University and Research. Soil Physics and Land Management Group; Países Bajos. Fil: Hofman, Jakub. Masaryk University. Faculty of Science. Research Centre for Toxic Compounds in the Environment; Republica Checa. Fil: Kandeler, Ellen. University of Hohenheim. Institute of Soil Science and Land Evaluation; Alemania. Fil: Abrantes, Nelson. University of Aveiro. Centre for Environmental and Marine Studies and Department of Environment and Planning; Portugal. Fil: Campos, Isabel. University of Aveiro. Centre for Environmental and Marine Studies and Department of Environment and Planning; Portugal. Fil: Martínez, María Ángeles. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas; España. Fil: Pereira, Joana Luísa. Centre for Environmental and Marine Studies and Department of Environment and Planning; Portugal. Fil: Goossens, Dirk. Wageningen University and Research. Soil Physics and Land Management Group. Países Bajos. KU Leuven Department of Earth and Environmental Sciences; Belgica. Fil: Gandrass, Juergen. Institute of Coastal Environmental Chemistry; Alemania. Fil: Debler, Freya. Institute of Coastal Environmental Chemistry; Alemania. Fil: Huerta Lwanga, Esperanza. Wageningen University and Research. Soil Physics and Land Management Group; Países Bajos. Fil: Jonker, Marlot. Dutch Mammal Society; Países Bajos. Fil: Van Langevelde, Frank. Wageningen University and Research. Wildlife Ecology and Conservation Group; Países Bajos. Fil: Sorensen, Martin. Aarhus University. Department of Animal Science; Dinamarca. Fil: Wells, Jerry. Wageningen University and Research. Host-Microbe Interactomics, Animal Sciences Group; Países Bajos. Fil: Boekhorst, Jos. Wageningen University and Research. Host-Microbe Interactomics, Animal Sciences Group; Países Bajos. Fil: Huss, Anke. Utrecht University. Institute for Risk Assessment Sciences; Países Bajos. Fil: Mandrioli, Daniele. Ramazzini Institute. Cesare Maltoni Cancer Research Center; Italia. Fil: Sgargi, Daria. Ramazzini Institute. Cesare Maltoni Cancer Research Center; Italia. Fil: Nathanail, Paul. Land Quality Management; Reino Unido. Fil: Nathanail, Judith. Land Quality Management; Reino Unido. Fil: Tamm, Lucius. Research Institute of Organic Agriculture; Suiza. Fil: Fantke, Peter. Technical University of Denmark. Department of Technology, Management and Economics; Dinamarca. Fil: Mark, Jennifer. Research Institute of Organic Agriculture; Suiza. Fil: Grovermann, Christian. Research Institute of Organic Agriculture; Suiza. Fil: Larsen, Ana Frelih. Ecologic Institute; Alemania. Fil: Herb, Irina. Ecologic Institute; Alemania. Fil: Chivers, Charlotte Anne. University of Gloucestershire. Countryside and Community Research Institute; Reino Unido. Fil: Mills, Jane. University of Gloucestershire. Countryside and Community Research Institute; Reino Unido. Fil: Alcon, Francisco. Universidad Politécnica de Cartagena; España. Fil: Contreras, Josefina. Universidad Politécnica de Cartagena; España. Fil: Baldi, Isabelle. Bordeaux University. INSERM U1219; Francia. Fil: Pasković, Igor. Institute of Agriculture and Tourism, Department of Agriculture and Nutrition; Croacia. Fil: Matjaz, Glavan. University of Ljubljana. Biotechnical Faculty; Eslovenia. Fil: Norgaard, Trine. Aarhus University. Department of Agroecology; Dinamarca. Fil: Aparicio, Virginia Carolina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Ritsema, Coen. Wageningen University and Research. Soil Physics and Land Management Group; Países Bajos. Fil: Geissen, Violette. University and Research. Soil Physics and Land Management Group; Países Bajos. Fil: Scheepers, Paul. Radboud Institute for Health Sciences; Países Bajos.

Published
2021
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10. Assessment of exposure of gas station attendants in Sri Lanka to benzene, toluene and xylenes

Author

Laurie de Werdt, Matteo Creta, Paul T.J. Scheepers, D.T.D. Warnakulasuriya, Rob B. M. Anzion, Lode Godderis, Radu Corneliu Duca, Niranga Manjuri Devanarayana, Jeroen Vanoirbeek, and Maurice van Dael

Subjects
BANGKOK, BLOOD, HEALTH-RISK ASSESSMENT, 010501 environmental sciences, Urine, 01 natural sciences, Biochemistry, law.invention, chemistry.chemical_compound, 0302 clinical medicine, law, ENVIRONMENTAL EXPOSURE, 030212 general & internal medicine, PETROL PUMPS, Benzene, General Environmental Science, Public, Environmental & Occupational Health, AIR, WORKERS, Environmental exposure, Exhaled air, OCCUPATIONAL-EXPOSURE, Environmental chemistry, Life Sciences & Biomedicine, Environmental Monitoring, Environmental Sciences & Ecology, Air Pollutants, Occupational, Xylenes, VOLATILE ORGANIC-COMPOUNDS, GASOLINE, Mass spectrometry, Gas Chromatography-Mass Spectrometry, 03 medical and health sciences, Occupational Exposure, Flame ionization detector, Humans, Volatile organic compounds, Gasoline, 0105 earth and related environmental sciences, Sri Lanka, Science & Technology, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Toluene, chemistry, Environmental science, Gas chromatography, Occupational hygiene, Gas chromatography–mass spectrometry, Environmental Sciences
Abstract

Exposure to benzene, toluene and p-, m-, o-xylene (BTX) was studied in 29 gas station attendants and 16 office workers in Sri Lanka. The aim of this study was to assess the exposure level and identify potential exposure mitigating measures. Pre- and post-shift samples of end-exhaled air were collected and analysed for BTX on a thermal desorption gas chromatography mass spectrometry system (TD-GC-MS). Urine was collected at the same timepoints and analysed for a metabolite of benzene, S-phenyl mercapturic acid (SPMA), using liquid chromatography-mass spectrometry (LC-MS). Environmental exposure was measured by personal air sampling and analysed by gas chromatography flame ionization detection (GC-FID). Median (range) breathing zone air concentrations were 609 (65.1-1960) μg/m3 for benzene and 746 (

Published
2019
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11. Intrusion of Chlorinated Hydrocarbons and their Degradation Products from Contaminated Soil: Measurement of Indoor Air Quality and Biomonitoring by Analysis of End-Exhaled Air

Author

Paul T.J. Scheepers, Martien H.F. Graumans, Rob B. M. Anzion, Maurice van Dael, Laurie de Werdt, and Nicole Pinckaers

Subjects
Intrusion, Indoor air quality, Environmental chemistry, Biomonitoring, General Earth and Planetary Sciences, Degradation (geology), Environmental science, Soil contamination, Exhaled air, General Environmental Science
Published
2018
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12. Intrusion of chlorinated hydrocarbons and their degradation products from contaminated soil. Measurement of indoor air quality and biomonitoring by analysis of end-exhaled air

Author

Maurice van Dael, Gwendolyn Beckmann, Paul T.J. Scheepers, Laurie de Werdt, Rob B. M. Anzion, Nicole Pinckaers, and Martien H.F. Graumans

Subjects
Pollution, Adult, Male, Environmental Engineering, 010504 meteorology & atmospheric sciences, Trichloroethylene, media_common.quotation_subject, Tetrachloroethylene, 010501 environmental sciences, 01 natural sciences, Gas Chromatography-Mass Spectrometry, chemistry.chemical_compound, All institutes and research themes of the Radboud University Medical Center, Indoor air quality, Hydrocarbons, Chlorinated, Environmental Chemistry, Humans, Soil Pollutants, Waste Management and Disposal, Air quality index, 0105 earth and related environmental sciences, media_common, Netherlands, Pollutant, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Contamination, Middle Aged, Soil contamination, chemistry, Breath Tests, Environmental chemistry, Air Pollution, Indoor, Environmental science, Female, Environmental Monitoring
Abstract

A historic soil contamination of chlorinated hydrocarbons from a former dry cleaning shop caused intrusion of vapors into a building currently used as bookshop. The aim of this study was to determine the indoor air quality and the uptake of soil contaminants and their degradation products. Samples of indoor air were collected over one week in the warm and one week in the cold season. Pre-shift and post-shift samples of end-exhaled air were collected from two employees. Chlorinated hydrocarbons were analyzed in indoor air and exhaled air samples using thermal desorption gas chromatography mass spectrometry (TD-GC–MS). Tetrachloroethylene (PER), and its degradation products trichloroethylene (TRI), 1,1-dichloroethylene (1,1-DCE), 1,2-cis-dichloroethylene (1,2-cis-DCE), 1,2-trans-dichloroethylene (1,2-trans-DCE), methylene chloride (MC) and vinyl chloride (VC) were determined in ambient air. PER was the prime contaminant with a week average (±sd) of 805.2 ± 598.6 μg/m3 in June 2016 and 1031 ± 499.3 μg/m3 in December 2017. MC, 1,2-cis-DCE and TRI were detected at concentrations below 2.3 μg/m3. 1,1-DCE and VC were not detected. In exhaled air PER, 1,1-DCE, and MC were detected in both June and December, whereas TRI, 1,2-cis-DCE and 1,2-trans-DCE were only detected on one or two days in the cold season. VC was not detected in exhaled air. For PER, the mean concentrations (±sd) in end-exhaled air increased from a five days (Mon-Fri) average pre-shift value of 22.2 ± 8.0 to a post-shift value of 52.6 ± 15.5 ng/L in the male shop owner (p

Published
2018

13. A comprehensive full factorial LC-MS/MS proteomics benchmark data set

Author

Lambert P. van den Heuvel, Tom G. Bloemberg, Maurice van Dael, Jolein Gloerich, Hans J. C. T. Wessels, Ron Wehrens, and Lutgarde M. C. Buydens

Subjects
Proteomics, Technology, Factorial, Proteome, Genomic disorders and inherited multi-system disorders Energy and redox metabolism [IGMD 3], Ovalbumin, Computer science, Liquid chromatography, computer.software_genre, Carbonic Anhydrase II, Biochemistry, Renal disorder Energy and redox metabolism [IGMD 9], Analytical Chemistry, Set (abstract data type), Tandem Mass Spectrometry, Escherichia coli, Animals, Databases, Protein, Molecular Biology, Benchmark data set, Ground truth, Chromatography, Mass spectrometry, Escherichia coli Proteins, Mitochondrial medicine Energy and redox metabolism [IGMD 8], Factorial experiment, Peptide Fragments, Data set, Renal disorder Membrane transport and intracellular motility [IGMD 9], Mitochondrial medicine [IGMD 8], Cattle, Data mining, Benchmark data, Chickens, computer, Chromatography, Liquid
Abstract

Item does not contain fulltext An important prerequisite for the development and benchmarking of novel analysis methods is a well-designed comprehensive LC-MS/MS data set. Here, we present our data set consisting of 59 LC-MS/MS analyses of 50 protein samples extracted individually from Escherichia coli K12 and spiked with different concentrations of bovine carbonic anhydrase II and/or chicken ovalbumin, according to a 2 x 3 full factorial design. Using the well-annotated and commonly used E. coli proteome as the sample background ensures that the complexity of the data is on a par with most current proteomic analyses. Data were acquired over a 2-month period using multiple reversed-phase columns and instrument calibrations to include real-life challenges faced when analyzing large proteomics data sets. Moreover, so-called "ground truth" data, comprised by LC-MS/MS measurements of the pure spikes are included in the data set. The current manuscript elaborates this comprehensive benchmark data set for future development and evaluation of analysis methods and software. 01 augustus 2012

Published
2012
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14. Pinpointing biomarkers in proteomic LC/MS data by moving-window discriminant analysis

Author

Lutgarde M. C. Buydens, Hans J. C. T. Wessels, Tom G. Bloemberg, Jolein Gloerich, Ron Wehrens, Maurice van Dael, and Lambert P. van den Heuvel

Subjects
Proteomics, Multivariate statistics, Genomic disorders and inherited multi-system disorders Energy and redox metabolism [IGMD 3], Chemistry, Analytical chemistry, Univariate, Discriminant Analysis, Mitochondrial medicine Energy and redox metabolism [IGMD 8], Moving window, Computational biology, Linear discriminant analysis, Renal disorder Energy and redox metabolism [IGMD 9], Mass Spectrometry, Analytical Chemistry, Data set, Renal disorder Membrane transport and intracellular motility [IGMD 9], Mitochondrial medicine [IGMD 8], Liquid chromatography–mass spectrometry, Humans, Shotgun proteomics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Biomarkers, Chromatography, Liquid
Abstract

The identification of differential patterns in data originating from combined measurement techniques such as LC/MS is pivotal to proteomics. Although “shotgun proteomics” has been employed successfully to this end, this method also has severe drawbacks, because of its dependence on largely untargeted MS/MS sequencing and databases for statistical analyses. Alternatively, several MS-signal-based (MS/MS-independent) methods have been published that are mainly based on (univariate) Student’s t-tests. Here, we present a more robust multivariate alternative employing linear discriminant analysis. Like the t-test-based methods, it is applied directly to LC/MS data, instead of using MS/MS measurements. We demonstrate the method on a number of simulated data sets, as well as on a spike-in LC/MS data set, and show its superior performance over t-tests.

Published
2011

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