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3. Towards clinical breakpoints for non-tuberculous mycobacteria - Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution.

Author

Fröberg, G., Maurer, F.P., Chryssanthou, E., Fernström, L., Benmansour, H., Boarbi, S., Mengshoel, A.T., Keller, P.M., Viveiros, M., Machado, D., Fitzgibbon, M.M., Mok, S., Werngren, J., Cirillo, D.M., Alcaide, F., Hyyryläinen, H.L., Aubry, A., Andres, S., Nadarajan, D., Svensson, E., Turnidge, J., Giske, C.G., Kahlmeter, G., Cambau, E., Ingen, J. van, Schön, T., Fröberg, G., Maurer, F.P., Chryssanthou, E., Fernström, L., Benmansour, H., Boarbi, S., Mengshoel, A.T., Keller, P.M., Viveiros, M., Machado, D., Fitzgibbon, M.M., Mok, S., Werngren, J., Cirillo, D.M., Alcaide, F., Hyyryläinen, H.L., Aubry, A., Andres, S., Nadarajan, D., Svensson, E., Turnidge, J., Giske, C.G., Kahlmeter, G., Cambau, E., Ingen, J. van, and Schön, T.

Abstract

01 juni 2023, Item does not contain fulltext, OBJECTIVE: For non-tuberculous mycobacteria (NTM), minimum inhibitory concentration (MIC) distributions of wild-type isolates have not been systematically evaluated despite their importance for establishing antimicrobial susceptibility testing (AST) breakpoints. METHODS: We gathered MIC distributions for drugs used against the Mycobacterium avium complex (MAC) and Mycobacterium abscessus (MAB) obtained by commercial broth microdilution (SLOMYCOI and RAPMYCOI) from 12 laboratories. Epidemiological cut-off values (ECOFFs) and tentative ECOFFs (TECOFFs) were determined by EUCAST methodology including quality control (QC) strains. RESULTS: The clarithromycin ECOFF was 16 mg/L for M. avium (n = 1271) whereas TECOFFs were 8 mg/L for M. intracellulare (n = 415) and 1 mg/L for MAB (n = 1014) confirmed by analysing MAB subspecies without inducible macrolide resistance (n = 235). For amikacin, the ECOFFs were 64 mg/L for MAC and MAB. For moxifloxacin, the WT spanned >8 mg/L for both MAC and MAB. For linezolid, the ECOFF and TECOFF were 64 mg/L for M. avium and M. intracellulare, respectively. Current CLSI breakpoints for amikacin (16 mg/L), moxifloxacin (1 mg/L) and linezolid (8 mg/L) divided the corresponding WT distributions. For QC M. avium and M. peregrinum, ≥95% of MIC values were well within recommended QC ranges. CONCLUSION: As a first step towards clinical breakpoints for NTM, (T)ECOFFs were defined for several antimicrobials against MAC and MAB. Broad wild-type MIC distributions indicate a need for further method refinement which is now under development within the EUCAST subcommittee for anti-mycobacterial drug susceptibility testing. In addition, we showed that several CLSI NTM breakpoints are not consistent in relation to the (T)ECOFFs.

Published
2023

4. Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement.

Author

Domínguez, J., Boeree, M.J., Cambau, E., Chesov, D., Conradie, F., Cox, V., Dheda, K., Dudnyk, A., Farhat, M.R., Gagneux, S., Grobusch, M.P., Gröschel, M.I., Guglielmetti, L., Kontsevaya, I., Lange, B., Leth, F. van, Lienhardt, C., Mandalakas, A.M., Maurer, F.P., Merker, M., Miotto, P., Molina-Moya, B., Morel, F., Niemann, S., Veziris, N., Whitelaw, A., Horsburgh CR, J.r., Lange, C de, Domínguez, J., Boeree, M.J., Cambau, E., Chesov, D., Conradie, F., Cox, V., Dheda, K., Dudnyk, A., Farhat, M.R., Gagneux, S., Grobusch, M.P., Gröschel, M.I., Guglielmetti, L., Kontsevaya, I., Lange, B., Leth, F. van, Lienhardt, C., Mandalakas, A.M., Maurer, F.P., Merker, M., Miotto, P., Molina-Moya, B., Morel, F., Niemann, S., Veziris, N., Whitelaw, A., Horsburgh CR, J.r., and Lange, C de

Abstract

01 april 2023, Item does not contain fulltext, Drug-resistant tuberculosis is a substantial health-care concern worldwide. Despite culture-based methods being considered the gold standard for drug susceptibility testing, molecular methods provide rapid information about the Mycobacterium tuberculosis mutations associated with resistance to anti-tuberculosis drugs. This consensus document was developed on the basis of a comprehensive literature search, by the TBnet and RESIST-TB networks, about reporting standards for the clinical use of molecular drug susceptibility testing. Review and the search for evidence included hand-searching journals and searching electronic databases. The panel identified studies that linked mutations in genomic regions of M tuberculosis with treatment outcome data. Implementation of molecular testing for the prediction of drug resistance in M tuberculosis is key. Detection of mutations in clinical isolates has implications for the clinical management of patients with multidrug-resistant or rifampicin-resistant tuberculosis, especially in situations when phenotypic drug susceptibility testing is not available. A multidisciplinary team including clinicians, microbiologists, and laboratory scientists reached a consensus on key questions relevant to molecular prediction of drug susceptibility or resistance to M tuberculosis, and their implications for clinical practice. This consensus document should help clinicians in the management of patients with tuberculosis, providing guidance for the design of treatment regimens and optimising outcomes.

Published
2023

5. Pretomanid-resistant tuberculosis.

Author

Koehler, N., Andres, S., Merker, M., Dreyer, V., John, A., Kuhns, M., Krieger, D., Choong, E., Verougstraete, N., Wiesch, P.A. Zur, Wicha, S.G., König, C., Kalsdorf, B., Sanchez Carballo, P.M., Schaub, D., Werngren, J., Schön, T., Peloquin, C.A., Schönfeld, N., Verstraete, A.G., Decosterd, L.A., Aarnoutse, R.E., Niemann, S., Maurer, F.P., Lange, C de, Koehler, N., Andres, S., Merker, M., Dreyer, V., John, A., Kuhns, M., Krieger, D., Choong, E., Verougstraete, N., Wiesch, P.A. Zur, Wicha, S.G., König, C., Kalsdorf, B., Sanchez Carballo, P.M., Schaub, D., Werngren, J., Schön, T., Peloquin, C.A., Schönfeld, N., Verstraete, A.G., Decosterd, L.A., Aarnoutse, R.E., Niemann, S., Maurer, F.P., and Lange, C de

Abstract

Item does not contain fulltext

Published
2023

7. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

Author

Hasse, B., Hannan, M.M., Keller, P.M., Maurer, F.P., Sommerstein, R., Mertz, D., Ingen, J. van, Halbe, M., Perkins, K.M., Hasse, B., Hannan, M.M., Keller, P.M., Maurer, F.P., Sommerstein, R., Mertz, D., Ingen, J. van, Halbe, M., and Perkins, K.M.

Abstract

Contains fulltext : 216662.pdf (Publisher’s version ) (Open Access)

Published
2020

8. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass.

Author

Sander P., Chu V.H., Durack D.T., Fortes C.Q., Fowler V., Krachmer A.W., Wilson W.R., Stewart R., Herwaldt L.A., Widmer A., Brown Elliot B.A., Falk V., Halbe M., Scriven J.E., Sax H., van Ingen J., Mestres C.A., Diekema D., Brown-Elliott B.A., Wallace R.J., Baddour L.M., Miro J.M., Hoen B., Athan E., Bayer A., Barsic B., Stuart R.L., Hasse B., Hannan M.M., Keller P.M., Maurer F.P., Sommerstein R., Mertz D., Wagner D., Fernandez-Hidalgo N., Nomura J., Manfrin V., Bettex D., Hernandez Conte A., Durante-Mangoni E., Tang T.H.-C., Lundgren J., Gordon S., Jarashow M.C., Schreiber P.W., Niemann S., Kohl T.A., Daley C.L., Stewardson A.J., Whitener C.J., Perkins K., Plachouras D., Lamagni T., Chand M., Freiberger T., Zweifel S., Corey G.R., Schulthess B., Sander P., Chu V.H., Durack D.T., Fortes C.Q., Fowler V., Krachmer A.W., Wilson W.R., Stewart R., Herwaldt L.A., Widmer A., Brown Elliot B.A., Falk V., Halbe M., Scriven J.E., Sax H., van Ingen J., Mestres C.A., Diekema D., Brown-Elliott B.A., Wallace R.J., Baddour L.M., Miro J.M., Hoen B., Athan E., Bayer A., Barsic B., Stuart R.L., Hasse B., Hannan M.M., Keller P.M., Maurer F.P., Sommerstein R., Mertz D., Wagner D., Fernandez-Hidalgo N., Nomura J., Manfrin V., Bettex D., Hernandez Conte A., Durante-Mangoni E., Tang T.H.-C., Lundgren J., Gordon S., Jarashow M.C., Schreiber P.W., Niemann S., Kohl T.A., Daley C.L., Stewardson A.J., Whitener C.J., Perkins K., Plachouras D., Lamagni T., Chand M., Freiberger T., Zweifel S., Corey G.R., and Schulthess B.

Abstract

Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary bypass surgery is high and there is a growing need for a consensus-based expert opinion to provide international guidance for diagnosing, preventing and treating in these patients. In this document the International Society for Cardiovascular Infectious Diseases (ISCVID) covers aspects of prevention (field of hospital epidemiology), clinical management (infectious disease specialists, cardiac surgeons, ophthalmologists, others), laboratory diagnostics (microbiologists, molecular diagnostics), device management (perfusionists, cardiac surgeons) and public health aspects.Copyright © 2019 The Author(s)

Published
2020

9. WS13.5 Molecular epidemiology of Mycobacterium abscessus isolates recovered from German cystic fibrosis patients

Author

Wetzstein, N., primary, Diricks, M., additional, Kohl, T.A., additional, Wichelhaus, T.A., additional, Andres, S., additional, Pawlowski, L., additional, Schwarz, C., additional, Lewin, A., additional, Kehrmann, J., additional, Kahl, B.C., additional, Hügel, C., additional, Eickmeier, O., additional, Smaczny, C., additional, Maurer, F.P., additional, Niemann, S., additional, and Hogardt, M., additional

Published
2021
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11. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

Author

Hasse, B., primary, Hannan, M.M., additional, Keller, P.M., additional, Maurer, F.P., additional, Sommerstein, R., additional, Mertz, D., additional, Wagner, D., additional, Fernández-Hidalgo, N., additional, Nomura, J., additional, Manfrin, V., additional, Bettex, D., additional, Hernandez Conte, A., additional, Durante-Mangoni, E., additional, Tang, T.H.-C., additional, Stuart, R.L., additional, Lundgren, J., additional, Gordon, S., additional, Jarashow, M.C., additional, Schreiber, P.W., additional, Niemann, S., additional, Kohl, T.A., additional, Daley, C.L., additional, Stewardson, A.J., additional, Whitener, C.J., additional, Perkins, K., additional, Plachouras, D., additional, Lamagni, T., additional, Chand, M., additional, Freiberger, T., additional, Zweifel, S., additional, Sander, P., additional, Schulthess, B., additional, Scriven, J.E., additional, Sax, H., additional, van Ingen, J., additional, Mestres, C.A., additional, Diekema, D., additional, Brown-Elliott, B.A., additional, Wallace, R.J., additional, Baddour, L.M., additional, Miro, J.M., additional, Hoen, B., additional, Athan, E., additional, Bayer, A., additional, Barsic, B., additional, Corey, G.R., additional, Chu, V.H., additional, Durack, D.T., additional, Fortes, C.Q., additional, Fowler, V., additional, Krachmer, A.W., additional, Durante-Magnoni, E., additional, Wilson, W.R., additional, Hasse, B., additional, Scriven, J., additional, Stewart, R., additional, Herwaldt, L.A., additional, Schreiber, P., additional, Stewardson, A., additional, Widmer, A., additional, Brown Elliot, B.A., additional, Daley, C., additional, Keller, P., additional, Maurer, F., additional, Falk, V., additional, Halbe, M., additional, and Perkins, K.M., additional

Published
2020
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12. Comparative analysis of phenotypic and genotypic antibiotic susceptibility patterns in Mycobacterium avium complex

Author

Wetzstein, N., Kohl, T.A., Andres, S., Schultze, T.G., Geil, A., Kim, E., Biciusca, T., Hügel, C., Hogardt, M., Lehn, A., Vehreschild, M.J.G.T., Wolf, T., Niemann, S., Maurer, F.P., Wichelhaus, T.A., and Publica

Subjects
Adult, Male, Adolescent, Genotype, Microbial Sensitivity Tests, lcsh:Infectious and parasitic diseases, Cohort Studies, Young Adult, Drug Resistance, Bacterial, Humans, lcsh:RC109-216, ddc:610, Child, Aged, Mycobacterium avium-intracellulare Infection, Aged, 80 and over, Infant, Middle Aged, bacterial infections and mycoses, Mycobacterium avium Complex, Anti-Bacterial Agents, Aminoglycosides, Phenotype, Child, Preschool, Macrolides, Rifampin
Abstract

Objective: Phenotypic (Sensititre Myco, pDST) and genotypic drug susceptibility testing (GenoType NTM DR, gDST) in M. avium complex (MAC) have become available as standardized assays, but comparable data is needed. This study aimed to investigate the phenotypic and genotypic drug susceptibility patterns in MAC clinical isolates. Methods: Overall, 98 isolates from 85 patients were included. pDST and gDST were performed on all isolates and results compared regarding specificity and sensitivity using pDST as a reference method. The impact of drug instability on pDST results was studied using a biological assay over 14 days. In addition, the evolution of antimicrobial resistance was investigated in sequential isolates of 13 patients. Results: Macrolide resistance was rare, 1.2% (95% CI 0.7–7.3) of isolates in the base cohort. No aminoglycoside resistances were found, but 14.1% of the studied isolates (95% CI 7.8–23.8) showed intermediate susceptibility. The GenoType NTM DR identified two out of four macrolide-resistant isolates. Antibiotic stability was demonstrated to be poor in rifampicin, rifabutin, and doxycycylin. Conclusions: pDST results in NTM for unstable antibiotics must be interpreted with care. A combination of pDST and gDST will be useful for the guidance of antimicrobial therapy in MAC-disease. Keywords: NTM, Non-tuberculous mycobacteria, M. avium complex, M. avium, M. chimaera, M. Intracellulare, Drug susceptibility testing, DST

Published
2019

13. Same meat, different gravy: ignore the new names of mycobacteria

Author

Tortoli, E., Brown-Elliott, B.A., Chalmers, J.D., Cirillo, D.M., Daley, C.L., Emler, S., Floto, R.A., Garcia, M.J., Hoefsloot, W., Koh, W.J., Lange, C de, Loebinger, M., Maurer, F.P., Morimoto, K., Niemann, S., Richter, E., Turenne, C.Y., Vasireddy, R., Vasireddy, S., Wagner, D., Wallace, R.J., Wengenack, N., Ingen, J. van, Tortoli, E., Brown-Elliott, B.A., Chalmers, J.D., Cirillo, D.M., Daley, C.L., Emler, S., Floto, R.A., Garcia, M.J., Hoefsloot, W., Koh, W.J., Lange, C de, Loebinger, M., Maurer, F.P., Morimoto, K., Niemann, S., Richter, E., Turenne, C.Y., Vasireddy, R., Vasireddy, S., Wagner, D., Wallace, R.J., Wengenack, N., and Ingen, J. van

Abstract

Contains fulltext : 208559.pdf (publisher's version ) (Closed access)

Published
2019

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