Search

Your search keyword '"Maurer, Elisabeth"' showing total 353 results
Start Over Author "Maurer, Elisabeth"
353 results on '"Maurer, Elisabeth"'

8. PITX2 as a Sensitive and Specific Marker of Midgut Neuroendocrine Tumors: Results from a Cohort of 1157 Primary Neuroendocrine Neoplasms

Author

Grass, Albert, Kasajima, Atsuko, Foersch, Sebastian, Kriegsmann, Mark, Brobeil, Alexander, Schmitt, Maxime, Wagner, Daniel, Poppinga, Jelte, Wiese, Dominik, Maurer, Elisabeth, Kirschbaum, Andreas, Muley, Thomas, Winter, Hauke, Rinke, Anja, Gress, Thomas M., Kremer, Markus, Evert, Matthias, Märkl, Bruno, Quaas, Alexander, Eckstein, Markus, Tschurtschenthaler, Markus, Klöppel, Günter, Denkert, Carsten, Bartsch, Detlef K., and Jesinghaus, Moritz

Published
2024
Full Text
View/download PDF

11. Hyperthyreose

Author

Maurer, Elisabeth, Holzer, Katharina, Bartsch, Detlef K., Section editor, Bartsch, Detlef K., editor, and Holzer, Katharina, editor

Published
2023
Full Text
View/download PDF

24. Hals

Author

Maurer, Elisabeth, Bartsch, Detlef K., Schwab, Robert, editor, Germer, Christoph-Thomas, editor, and Lang, Hauke, editor

Published
2019
Full Text
View/download PDF

26. Two giant retroperitoneal schwannomas mimicking adrenal malignancy – a case report

Author

Fülber Isabelle, Peer Katharina, Maurer Elisabeth, Bartsch Detlef K., Görlach Jannis, Göbel Joachim Nils, Roeßler Marion, and Holzer Katharina

Subjects
case report, diagnosis, incidentaloma, multivisceral resection, retroperitoneal tumor, retroperitoneal schwannoma, schwannoma, Surgery, RD1-811
Abstract

Schwannomas are benign tumors in 95% of cases and very rarely occur in the retroperitoneum. We report the cases of a 35-year-old man with abdominal discomfort and a 50-year-old asymptomatic woman with large retroperitoneal masses. Both underwent multivisceral surgery to exclude an adrenal carcinoma, and the pathologic diagnosis showed schwannomas in both cases. Despite morphological imaging, it was not possible to get a clear diagnosis preoperatively.

Published
2020
Full Text
View/download PDF

29. Development and Validation of a Symptom-Based Activity Index for Adults With Eosinophilic Esophagitis

Author

Schoepfer, Alain M, Straumann, Alex, Panczak, Radoslaw, Coslovsky, Michael, Kuehni, Claudia E, Maurer, Elisabeth, Haas, Nadine A, Romero, Yvonne, Hirano, Ikuo, Alexander, Jeffrey A, Gonsalves, Nirmala, Furuta, Glenn T, Dellon, Evan S, Leung, John, Collins, Margaret H, Bussmann, Christian, Netzer, Peter, Gupta, Sandeep K, Aceves, Seema S, Chehade, Mirna, Moawad, Fouad J, Enders, Felicity T, Yost, Kathleen J, Taft, Tiffany H, Kern, Emily, Zwahlen, Marcel, Safroneeva, Ekaterina, and Group, International Eosinophilic Esophagitis Activity Index Study

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Clinical Research, Food Allergies, Adaptation, Psychological, Adult, Deglutition Disorders, Endoscopy, Gastrointestinal, Eosinophilic Esophagitis, Feeding Behavior, Female, Humans, Linear Models, Male, Reproducibility of Results, Self Report, Severity of Illness Index, Surveys and Questionnaires, Switzerland, United States, Disease Activity Measurement, Esophagus, Patient-Reported Outcome, Marker, International Eosinophilic Esophagitis Activity Index Study Group, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsStandardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations in patient assessments of disease severity. We also evaluated relationships between patient assessment of disease severity and EoE-associated endoscopic, histologic, and laboratory findings.MethodsWe collected information from 186 patients with EoE in Switzerland and the United States (69.4% male; median age, 43 y) via surveys (n = 135), focus groups (n = 27), and semistructured interviews (n = 24). Items were generated for the instruments to assess biologic activity based on physician input. Linear regression was used to quantify the extent to which variations in patient-reported disease characteristics could account for variations in patient assessment of EoE severity. The PRO instrument was used prospectively in 153 adult patients with EoE (72.5% male; median age, 38 y), and validated in an independent group of 120 patients with EoE (60.8% male; median age, 40.5 y).ResultsSeven PRO factors that are used to assess characteristics of dysphagia, behavioral adaptations to living with dysphagia, and pain while swallowing accounted for 67% of the variation in patient assessment of disease severity. Based on statistical consideration and patient input, a 7-day recall period was selected. Highly active EoE, based on endoscopic and histologic findings, was associated with an increase in patient-assessed disease severity. In the validation study, the mean difference between patient assessment of EoE severity (range, 0-10) and PRO score (range, 0-8.52) was 0.15.ConclusionsWe developed and validated an EoE scoring system based on 7 PRO items that assess symptoms over a 7-day recall period. Clinicaltrials.gov number: NCT00939263.

Published
2014

35. Total Versus Near-total Thyroidectomy in Graves Disease: Results of the Randomized Controlled Multicenter TONIG-trial

Author

Maurer, Elisabeth, Maschuw, Katja, Reuss, Alexander, Zieren, Hans Udo, Zielke, Andreas, Goretzki, Peter, Simon, Dietmar, Dotzenrath, Cornelia, Steinmüller, Thomas, Jähne, Joachim, Kemen, Matthias, Coerper, Stephan, Leister, Ingo, Nies, Christoph, Hartel, Mark, Türler, Andreas, Holzer, Katharina, Agha, Ayman, Knoop, Michael, Musholt, Thomas, Aminossadati, Benaz, and Bartsch, Detlef K.

Published
2019
Full Text
View/download PDF

43. Anti-Proliferative Effect of Radiotherapy and Implication of Immunotherapy in Anaplastic Thyroid Cancer Cells.

Author

Wächter, Sabine, Roth, Silvia, Gercke, Norman, Schötz, Ulrike, Dikomey, Ekkehard, Engenhart-Cabillic, Rita, Maurer, Elisabeth, Bartsch, Detlef K., and Di Fazio, Pietro

Subjects
ANAPLASTIC thyroid cancer, CANCER cells, PROGRAMMED cell death 1 receptors, PROGRAMMED death-ligand 1, CELL death, RADIOTHERAPY
Abstract

Radiotherapy and immunotherapy have shown promising efficacy for the treatment of solid malignancies. Here, we aim to clarify the potential of a combined application of radiotherapy and programmed cell death-ligand 1 (PD-L1) monoclonal antibody atezolizumab in primary anaplastic thyroid cancer (ATC) cells. The radiation caused a significant reduction in cell proliferation, measured by luminescence, and of the number of colonies. The addition of atezolizumab caused a further reduction in cell proliferation of the irradiated ATC cells. However, the combined treatment did not cause either the exposure of the phosphatidylserine or the necrosis, assessed by luminescence/fluorescence. Additionally, a reduction in both uncleaved and cleaved forms of caspases 8 and 3 proteins was detectable in radiated cells. The DNA damage evidenced the over-expression of TP53, CDKN1A and CDKN1B transcripts detected by RT-qPCR and the increase in the protein level of P-γH2AX and the DNA repair deputed kinases. PD-L1 protein level increased in ATC cells after radiation. Radiotherapy caused the reduction in cell viability and an increase of PD-L1-expression, but not apoptotic cell death in ATC cells. The further combination with the immunotherapeutic atezolizumab could increase the efficacy of radiotherapy in terms of reduction in cell proliferation. Further analysis of the involvement of alternative cell death mechanisms is necessary to clarify their cell demise mechanism of action. Their efficacy represents a promising therapy for patients affected by ATC. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

45. SLC13A5 is the second gene associated with Kohlschütter–Tönz syndrome

Author

Schossig, Anna, Bloch-Zupan, Agnès, Lussi, Adrian, Wolf, Nicole I, Raskin, Salmo, Cohen, Monika, Giuliano, Fabienne, Jurgens, Julie, Krabichler, Birgit, Koolen, David A, de Macena Sobreira, Nara Lygia, Maurer, Elisabeth, Muller-Bolla, Michèle, Penzien, Johann, Zschocke, Johannes, Kapferer-Seebacher, Ines, Joseph, Clara, Perelman, Serge, von Hülsen, Elke, de Souza, Cleber, Kohlschütter, Alfried, Tönz, Otmar, and Verhoeven, Judith S

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results