Search

Your search keyword '"Maugeri, Alessandro"' showing total 45 results
Start Over Author "Maugeri, Alessandro"
45 results on '"Maugeri, Alessandro"'

20. Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms

Author

Cirmi, Santa, primary, Maugeri, Alessandro, additional, Micali, Antonio, additional, Marini, Herbert Ryan, additional, Puzzolo, Domenico, additional, Santoro, Giuseppe, additional, Freni, Jose, additional, Squadrito, Francesco, additional, Irrera, Natasha, additional, Pallio, Giovanni, additional, Navarra, Michele, additional, and Minutoli, Letteria, additional

Published
2021
Full Text
View/download PDF

23. Exploring the chemical constituents and biological activities of leaf and twig extracts of two Amygdalusspecies from Turkey's flora: Cell-free, in vitroand molecular docking approaches

Author

Zengin, Gokhan, Yagi, Sakina, Cziáky, Zoltán, Jekő, József, Yildiztugay, Evren, Maugeri, Alessandro, Russo, Caterina, Cetiz, Mehmet Veysi, and Navarra, Michele

Abstract

Wild species of the subgenus Amygdalus(genus Prunusand family Rosaceae) have been insufficiently studied with regard to their chemical components and their pharmacological potential. The present study aimed at the investigation of the chemical composition of leaves and twigs of A. orientalisMill. and A. zielinskiiBrowicz, thus assessing the antioxidant and enzyme inhibiting potential, as well as to define the safety profile. Our results showed that extracts were rich in phenolics, and liquid chromatography-diode array detector-tandem mass spectrometry (LC-DAD-MS) analysis allowed the identification of phenolic acids, flavonoids, coumarins, proanthocyanins, amino acids, fatty acids and derivatives. The assessment of the antioxidant potential demonstrated that the ethyl acetate extract of A. zielinskiitwigs recorded the highest anti-ABTS (2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (1298.10 mg trolox equivalent (TE)/g), total antioxidant (4.98 mmol TE/g), Cu++(1211.47 mg TE/g) and Fe+++(907.86 mg TE/g) reducing properties. In addition, it also had the highest anti-DPPH (2,2-diphenyl-1-picrylhydrazyl) activity (560.17 mg TE/g), together with its methanolic extract and that of A. orientalistwigs, whereas the best chelation power was exerted by the ethyl acetate extract of A. orientalisleaves (31.10 mg EDTAE/g). Regarding enzyme inhibition, methanolic extracts of the leaves and twigs of both species displayed the highest α-glucosidase and tyrosinase inhibitory activity, while ethyl acetate extracts of A. orientalistwigs and leaves revealed the best butyrylcholinesterase (2.35 mg galantamine equivalent (GALAE)/g) inhibitory activity. Docking studies demonstrated strong binding affinities of compounds like rutin, kaempferol derivatives, and isorhamnetin-3-O-rutinoside with the abovementioned enzymes, supporting the consistent inhibitory potential. Moreover, we investigated the potential cytotoxicity of these extracts in different human cell lines, thus proving their safety. These results highlight the potential of the two Amygdalusspecies as a new source of bioactive molecules for the development of health-promoting applications.

Published
2025
Full Text
View/download PDF

27. The chorioallantoic membrane: A novel approach to extrapolate data from a well‐established method.

Author

Maugeri, Alessandro, Lombardo, Giovanni E., Navarra, Michele, Cirmi, Santa, and Rapisarda, Antonio

Subjects
CHORIOALLANTOIS, VASCULAR endothelial growth factors, EXTRAPOLATION, NEOVASCULARIZATION inhibitors, TRETINOIN, CHICKEN embryos
Abstract

The chorioallantoic membrane (CAM) of the chicken embryo is a highly vascularized extra‐embryonic structure that has been widely used as an in vivo model for the evaluation of angiogenesis. This study was designed to optimize data extrapolation from the most exploited experimental protocol to improve its efficiency and the reliability of the obtainable results. In our study, we followed the most common procedure for CAM assay, employing retinoic acid and vascular endothelial growth factor as standards. CAMs were photographed at t0, t24, and t48; then, the main parameters of the predefined vascular network/area were evaluated. Subsequently, their variations in each CAM were calculated comparing them within the same CAM over the course of the whole treatment (t24 and t48), also comparing the treated CAMs respect to the untreated ones. Thus, we provide a novel approach aimed at extrapolating data from CAM assay that allows to (i) have a greater reliability and richness of data; (ii) better estimate the potential pro‐ and anti‐angiogenic activity of new candidate drugs; (iii) save both eggs and time for the experiments. The chorioallantoic membrane (CAM) is a structure exploited for the in vivo evaluation of angiogenesis. This study was designed to optimize data extrapolation from a well‐established experimental protocol to improve its efficiency and reliability of the obtainable results. Thus, we provide a novel approach aimed at extrapolating data from CAM assay that allows to (i) have a greater reliability and richness of data; (ii) better estimate the pro‐ and anti‐angiogenic activity of new drugs; (iii) save both eggs and time for the experiments. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

29. Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts

Author

Kubica, Paweł, primary, Szopa, Agnieszka, additional, Kokotkiewicz, Adam, additional, Miceli, Natalizia, additional, Taviano, Maria Fernanda, additional, Maugeri, Alessandro, additional, Cirmi, Santa, additional, Synowiec, Alicja, additional, Gniewosz, Małgorzata, additional, Elansary, Hosam O., additional, Mahmoud, Eman A., additional, El-Ansary, Diaa O., additional, Nasif, Omaima, additional, Luczkiewicz, Maria, additional, and Ekiert, Halina, additional

Published
2020
Full Text
View/download PDF

33. Anti-inflammatory effect of a flavonoid-rich extract of orange juice in adult zebrafish subjected to Vibrio anguillarum-induced enteritis.

Author

Cirmi, Santa, Randazzo, Basilio, Russo, Caterina, Musumeci, Laura, Maugeri, Alessandro, Montalbano, Giuseppe, Guerrera, Maria Cristina, Lombardo, Giovanni Enrico, and Levanti, Maria

Subjects
ORANGE juice, ADULTS, ENTERITIS, BRACHYDANIO, VIBRIO
Abstract

Inflammation-related pathologies remain a serious health problem with high costs for the community. Citrus flavonoids are known to possess important pharmacological properties, including anti-inflammatory activity. In this study we evaluated the effects of a flavonoid-rich extract of orange juice (OJe) in an experimental model of enteritis induced by Vibrio anguillarum in adult zebrafish (Danio rerio). Administration of V. anguillarum through live feed (Artemia nauplii) for three consecutive days caused evident signs of enteritis in zebrafish. Three days of treatment with OJe before the pathogenic insult resulted in a remarkable reduction of tissue inflammatory events as well as a molecular down-regulation of the inflammatory genes such as IL-1β, IL-6 and TNFα. Our data suggest that OJe counteracts the inflammation of zebrafish intestinal mucosa, indicating that the pool of flavonoids present in orange juice could be useful for the prevention of enteritis. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

40. Citrus fruits and their flavonoids in inflammatory bowel disease: an overview.

Author

Musumeci, Laura, Maugeri, Alessandro, Cirmi, Santa, Lombardo, Giovanni Enrico, Russo, Caterina, Gangemi, Sebastiano, Calapai, Gioacchino, and Navarra, Michele

Subjects
INFLAMMATORY bowel diseases, CITRUS fruits, CROHN'S disease, FLAVONOIDS, ULCERATIVE colitis
Abstract

Inflammatory bowel disease (IBD), with its major manifestations being Crohn's disease and ulcerative colitis, belongs to the gastrointestinal inflammatory disorders, whose main therapeutic approach is represented by synthetic anti-inflammatory drugs. However, they are often accompanied by many side effects that shifted the interest of the scientific community towards natural products. In this context, several studies asserted the anti-IBD effects of Citrus fruits and their flavonoids, thus the aim of the present review is to provide robust evidence favouring their role in the prevention and treatment of IBD. Key mechanisms relate to their anti-inflammatory and antioxidant properties, as well as their ability to modulate gut microbiota. All the findings collected in this review, lay the foundations for further studies in human with the aim of evaluating the concrete applicability as a novel preventive and therapeutic approach of Citrus fruits and their flavonoids. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

41. The link between the AMPK/SIRT1 axis and a flavonoid-rich extract of Citrus bergamia juice: A cell-free, in silico, and in vitro study.

Author

Maugeri, Alessandro, Ferlazzo, Nadia, De Luca, Laura, Gitto, Rosaria, and Navarra, Michele

Abstract

A previous report indicated that the flavonoid-rich extract of bergamot juice (BJe) exerts an anti-inflammatory effect through the activation of SIRT1 in leukemic monocytes THP-1 exposed to lipopolysaccharide (LPS). In this study, we deeply investigate the mode of action of BJe, along with its major flavonoids on SIRT1 through cell-free, in silico, and in vitro experimental models. In the cell-free assay, all the tested compounds as well as the whole BJe inhibited the deacetylase activity of SIRT1. This finding was reinforced by the results of the in silico study. In THP-1 cells exposed to LPS, a reduction of SIRT1 activity was observed, effect that was reverted by the pre-incubation with either BJe or its major flavonoids. This effect was also observed at gene level. Employing an activator and an inhibitor of AMP-activated protein kinase (AMPK; AICAR and dorsomorphin, respectively), we discovered its involvement in the activation of SIRT1 elicited by BJe or its major flavonoids in whole cell. Our study indicates the dual role of BJe and its components, depending on the employed experimental model as well as reveals their mode of action on the AMPK/SIRT1 axis, suggesting their role as promising candidates in pathologies in which this axis is implied. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

44. The Anticancer Effect of Natural Plant Alkaloid Isoquinolines.

Author

Yun, Dahye, Yoon, So Young, Park, Soo Jung, Park, Yoon Jung, Navarra, Michele, Efferth, Thomas, Cirmi, Santa, and Maugeri, Alessandro

Subjects
ALKALOIDS, ISOQUINOLINE alkaloids, NUCLEIC acids, CELL cycle, CELL death, TRADITIONAL medicine, ISOQUINOLINE
Abstract

Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

45. Citrus Flavonoids and Autoimmune Diseases: A Systematic Review of Clinical Studies.

Author

Musumeci L, Maugeri A, Russo C, Lombardo GE, Cirmi S, and Navarra M

Subjects
Citrus, Autoimmune Diseases drug therapy
Abstract

Background: Autoimmune diseases are chronic disorders in which the immune system does not recognize and attacks one self's healthy components. In this context, although natural remedies might represent a promising therapeutic strategy, evidence regarding Citrus flavonoids is still controversial., Objective: To summarize and critically discuss the clinical evidence on the effects of Citrus flavonoids on managing autoimmune diseases., Method: A systematic review of articles has been carried out independently by two authors using MEDLINE, Scopus and ISI Web of Science databases. Search terms comprised keywords related to Citrus flavonoids and autoimmune diseases. The last search was performed on the 16th of March, 2021. No language restrictions were applied. Systematic review and study selection were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Before starting the review, the authors defined the types of articles to be included. Three reviewers independently carried out the extraction of papers., Results: Ten clinical studies fulfilled the eligibility criteria and were included in the final review., Conclusion: The studies discussed in this review are heterogeneous. Indeed, some studies suggest using Citrus flavonoids in the frame of autoimmune disorders, whereas others discourage it. Hence, this systematic review highlights the need for further large-scale clinical studies to define the exact role of Citrus flavonoids in managing autoimmune diseases (PROSPERO number CRD42021234903)., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results