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479 results on '"Mauad T"'

1. Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma

Author

Campos H.S., Xisto D.G., Oliveira M.B.G., Teixeira I., Negri E.M., Mauad T., Carnielli D., Lima L.M., Barreiro E.J., Faffe D.S., Zin W.A., Lapa e Silva J.R., and Rocco P.R.M.

Subjects
Asthma, Lung function, Steroid, Phosphodiesterase inhibitors, BALB/c mice, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

The aim of the present study was to compare the efficacy of a novel phosphodiesterase 4 and 5 inhibitor, LASSBio596, with that of dexamethasone in a murine model of chronic asthma. Lung mechanics (airway resistance, viscoelastic pressure, and static elastance), histology, and airway and lung parenchyma remodeling (quantitative analysis of collagen and elastic fiber) were analyzed. Thirty-three BALB/c mice were randomly assigned to four groups. In the asthma group (N = 9), mice were immunized with 10 µg ovalbumin (OVA, ip) on 7 alternate days, and after day 40 they were challenged with three intratracheal instillations of 20 µg OVA at 3-day intervals. Control mice (N = 8) received saline under the same protocol. In the dexamethasone (N = 8) and LASSBio596 (N = 8) groups, the animals of the asthma group were treated with 1 mg/kg dexamethasone disodium phosphate (0.1 mL, ip) or 10 mg/kg LASSBio596 dissolved in dimethyl sulfoxide (0.2 mL, ip) 24 h before the first intratracheal instillation of OVA, for 8 days. Airway resistance, viscoelastic pressure and static elastance increased significantly in the asthma group (77, 56, and 76%, respectively) compared to the control group. The asthma group presented more intense alveolar collapse, bronchoconstriction, and eosinophil and neutrophil infiltration than the control group. Both LASSBio596 and dexamethasone inhibited the changes in lung mechanics, tissue cellularity, bronchoconstriction, as well as airway and lung parenchyma remodeling. In conclusion, LASSBio596 at a dose of 10 mg/kg effectively prevented lung mechanical and morphometrical changes and had the potential to block fibroproliferation in a BALB/c mouse model of asthma.

Published
2006

6. Dynamics and Heterogeneity of the Lung Immunopathology in Severe COVID-19

Author

Erjefalt, J, primary, De Souza Xavier Costa, N, additional, Jönsson, J, additional, Cozzolino, O, additional, Dantas, K, additional, Clausson, C, additional, Siddhuraj, P, additional, Lindö, C, additional, Ferreira Spina Lombardi, S, additional, Mendroni Júnior, A, additional, Antonangelo, L, additional, Silvério Faria, C, additional, Nunes Duarte Neto, A, additional, De Almeida Monteiro, R, additional, Rebello Pinho, J, additional, Soares Gomes-Gouvêa, M, additional, Verciano Pereira, R, additional, Sirino Monteiro, J, additional, Setubal, J, additional, Pierre De Oliveira, E, additional, Theodoro Filho, J, additional, Sanden, C, additional, Orengo, J, additional, Sleeman, M, additional, Ferraz Da Silva, L, additional, Nascimento Saldiva, P, additional, Dolhnikoff, M, additional, and Mauad, T, additional

Published
2022
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7. Differentially expressed genes in Diffuse Alveolar Damage (DAD) patterns of COVID-19.

Author

de Souza Xavier Costa, N, primary, Sirino Monteiro, J, additional, Erjefält, J, additional, Jönsson, J, additional, Cozzolino, O, additional, Dantas, K, additional, Clausson, C, additional, Siddhuraj, P, additional, Lindö, C, additional, Ferreira Spina Lombardi, S, additional, Mendroni Júnior, A, additional, Antonangelo, L, additional, Silvério Faria, C, additional, Nunes Duarte Neto, A, additional, Almeida Monteiro, R, additional, Rebello Pinho, J R, additional, Soares Gomes-Gouvêa, M, additional, Verciano Pereira, R, additional, Pierre De Oliveira, E, additional, Theodoro Filho, J, additional, Sanden, C, additional, Orengo, J, additional, Sleeman, M, additional, Ferraz Da Silva, L F, additional, Nascimento Saldiva, P, additional, Dolhnikoff, M, additional, Mauad, T, additional, and Setubal, J C, additional

Published
2022
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8. Correlation between lung inflammatory cells, viral load and cytokines in fatal COVID-19

Author

de Souza Xavier Costa, N, primary, Erjefält, J, additional, Jönsson, J, additional, Cozzolino, O, additional, Dantas, K, additional, Clausson, C, additional, Siddhuraj, P, additional, Lindö, C, additional, Ferreira Spina Lombardi, S, additional, Mendroni Júnior, A, additional, Antonangelo, L, additional, Silvério Faria, C, additional, Nunes Duarte Neto, A, additional, Almeida Monteiro, R, additional, Rebello Pinho, J R, additional, Soares Gomes-Gouvêa, M, additional, Verciano Pereira, R, additional, Sirino Monteiro, J, additional, Setubal, J C, additional, Pierre De Oliveira, E, additional, Theodoro Filho, J, additional, Sanden, C, additional, Orengo, J, additional, Sleeman, M, additional, Ferraz Da Silva, L F, additional, Nascimento Saldiva, P, additional, Dolhnikoff, M, additional, and Mauad, T, additional

Published
2022
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9. Effects of Air Pollution in São Paulo on Asthma and COPD symptoms

Author

Almeida, F M, primary, Moreira, T C L, additional, Oliveira, L M, additional, Righetti, R F, additional, Lopes, F D T Q S, additional, Alencar, A P, additional, Mauad, T, additional, Gouveia, N C, additional, Lotufo, P A, additional, Bensenor, I, additional, Santos, I S, additional, and Tibério, I F L C, additional

Published
2022
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12. Building knowledge in urban agriculture: the challenges of local food production in Sao Paulo and Melbourne

Author

Amato-Lourenco, LF, Buralli, RJ, Ranieri, GR, Hearn, AH, Williams, C, Mauad, T, Amato-Lourenco, LF, Buralli, RJ, Ranieri, GR, Hearn, AH, Williams, C, and Mauad, T

Abstract

Urban environments face multiple burdens and significant challenges related to food safety and sustainable agriculture. Urban agriculture remains fragmented and incipient in many cities worldwide. In their efforts to ensure sustainable urban food systems and provide public access to affordable and quality food, city governments must identify and pursue emerging opportunities. This study analyzed how São Paulo and Melbourne are working to overcome the related challenges.

Published
2021

13. Digging up the past: urban agriculture narratives in Melbourne and São Paulo

Author

Hearn, AH, Mauad, T, Williams, C, Amato-Lourenço, LF, Reis Ranieri, G, Hearn, AH, Mauad, T, Williams, C, Amato-Lourenço, LF, and Reis Ranieri, G

Abstract

As urban agriculture becomes increasingly recognised as a contributor to nutritional and civic wellbeing, real estate developers and community associations have promoted it to advance distinct agendas. The article analyses this phenomenon in Melbourne and São Paulo, where colonial and industrial legacies have set the stage for urban agriculture’s resurgence and resulting “internal contradictions.” Developers of upmarket condominiums in both cities advertise urban agriculture as a purchasable commodity capable of recovering customers’ lost connections with nature and each other. However, the gentrifying effects of these developments deepen rather than alleviate social and environmental ills. By contrast, community projects profiled in four case studies emphasised urban agriculture’s ability to confront the long-term neglect of land, employment, and environment. We conclude that the capacity of urban agriculture to improve food systems is enhanced when proponents develop historically informed narratives that engage and inform consumers and municipal governments.

Published
2021

15. Urban Agriculture and the Battle for History in Melbourne and São Paulo

Author

Thornton, A, Hearn, A, Mauad, T, Amato-Lourenco, L, Ranieri, G, Williams, C, Thornton, A, Hearn, A, Mauad, T, Amato-Lourenco, L, Ranieri, G, and Williams, C

Abstract

This edited collection explores urban food democracy as part of a broader policy-based approach to sustainable urban development. Conceptually, governance and social justice provide the analytical framework for a varied array of contributions which critically address issues including urban agriculture, smart cities, human health and wellbeing and urban biodiversity. Some chapters take the form of thematic, issue-based discussions, where others are constituted by empirical case studies. Contributing authors include both academic experts and practitioners who hail from a wide range of disciplines, professions and nations. All offer original research and robust consideration of urban food democracy in cities from across the Global North and South. Taken as a whole, this book makes a significant contribution to understanding the potential enabling role of good urban governance in developing formal urban food policy that is economically and socially responsive and in tune with forms of community-driven adaptation of space for the local production, distribution and consumption of nutritious food.

Published
2020

37. Pneumoconiosis after sericite inhalation

Author

Algranti, E, Handar, A M, Dumortier, P, Mendonça, E M C, Rodrigues, G L, Santos, A M A, Mauad, T, Dolhnikoff, M, De Vuyst, P, Saldiva, P H N, and Bussacos, M A

Published
2005

44. Green spaces, land cover, street trees and cardiovascular health in a megacity

Author

Lopes Moreira T, Polizel J, de Souza Santos I, Nascimento Saldiva P, F Silva Filho D, Bensenor I, A Lotufo P, and Mauad T

Subjects
Global and Planetary Change, Megacity, Geography, Epidemiology, Health, Toxicology and Mutagenesis, Cardiovascular health, Public Health, Environmental and Occupational Health, Land cover, Pollution, Environmental planning
Published
2019
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45. Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease

Author

Lapperre, T. S., Snoeck-Stroband, J. B., Gosman, M. M. E., Jansen, D. F., Schadewijk, A., Thiadens, H. A., Vonk, J. M., Boezen, H. M., Ten Hacken, N. H. T., Sont, J. K., Rabe, K. F., Kerstjens, H. A. M., Hiemstra, P. S., Wim Timens, Postma, D. S., Sterk, P. J., Kauffman, H. F., Reus, D., Barentsen, M. D. W., Zeinstra-Smit, M., Luteijn, A. J., Molen, T., Ter Veen, G., Maaren, M. S., Veltman, C. A., Verbokkem, A., Verhage, I., Vink-Klooster, H. K., Gast-Strookman, J., Janssen, K., Schrumpf, J. A., Smit-Bakker, J., Stolk, J., Tiré, A. C. J. A., Veen, H., Wijffels, M. M. E., Willems, L. N. A., Mauad, T., GLUCOLD Study Grp, Internal Medicine, Epidemiology, Surgery, Erasmus MC other, Pharmacy, Department of Strategic Management and Entrepreneurship, AII - Amsterdam institute for Infection and Immunity, and Pulmonology

Subjects
Male, medicine.medical_specialty, medicine.drug_class, Bronchi, Cell Count, Placebo, Gastroenterology, Fluticasone propionate, Drug Administration Schedule, Pulmonary function testing, Pulmonary Disease, Chronic Obstructive, Bronchodilator, Internal medicine, Forced Expiratory Volume, Administration, Inhalation, Internal Medicine, Medicine, Humans, Albuterol, Lung, Salmeterol Xinafoate, Fluticasone, Asthma, Aged, Inflammation, COPD, business.industry, Smoking, Sputum, General Medicine, Middle Aged, medicine.disease, Surgery, Bronchodilator Agents, Androstadienes, Treatment Outcome, Drug Therapy, Combination, Female, Salmeterol, Human medicine, business, medicine.drug
Abstract

Background: Inhaled corticosteroids (ICSs) and long-acting β2-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD). Objective: To determine whether long-term ICS therapy, with and without LABAs, reduces inflammation and improves pulmonary function in COPD. Design: Randomized, placebo-controlled trial. (ClinicalTrials.gov registration number: NCT00158847) Setting: 2 university medical centers in The Netherlands. Patients: 114 steroid-naive current or former smokers with moderate to severe COPD. Measurements: Cell counts in bronchial biopsies and sputum (primary outcome); methacholine responsiveness at baseline, 6, and 30 months; and clinical outcomes every 3 months. Intervention: Random assignment by minimization method to receive fluticasone propionate, 500 μg twice daily, for 6 months (n = 31) or 30 months (n = 26); fluticasone, 500 μg twice daily, and salmeterol, 50 μg twice daily, for 30 months (single inhaler; n = 28); or placebo twice daily (n = 29). Results: 101 patients were greater than 70% adherent to therapy. Fluticasone therapy decreased counts of mucosal CD3+ cells (-55% [95% CI, -74% to -22%]; P - 0.004), CD4- cells (-78% [CI, -88% to 60%]; P < 0.001), CD8+ cells (-57% [CI, -77% to -18%]; P = 0.010), and mast cells (-38% [CI, -60% to -2%]; P = 0.039) and reduced hyperresponsiveness (P = 0.036) versus placebo at 6 months, with effects maintained after 30 months. Fluticasone therapy for 30 months reduced mast cell count and increased eosinophil count and percentage of intact epithelium, with accompanying reductions in sputum neutrophil, macrophage, and lymphocyte counts and improvements in FEV1 decline, dyspnea, and quality of life. Reductions in inflammatory cells correlated with clinical improvements. Discontinuing fluticasone therapy at 6 months increased counts of CD3+ cells (120% [CI, 24% to 289%]; P = 0.007), mast cells (218% [CI, 99% to 407%]; P < 0.001), and plasma cells (118% [CI, 9% to 336%]; P = 0.028) and worsened clinical outcome. Adding salmeterol improved FEV1 level. Limitations: The study was not designed to evaluate clinical outcomes. Measurement of primary outcome was not available for 24% of patients at 30 months. Conclusion: ICS therapy decreases inflammation and can attenuate decline in lung function in steroid-naive patients with moderate to severe COPD. Adding LABAs does not enhance these effects. Primary Funding Source: Netherlands Organization for Scientific Research, Netherlands Asthma Foundation, GlaxoSmithKline of The Netherlands, University Medical Center Groningen, and Leiden University Medical Center.

Published
2009

46. Airway pathology in severe asthma is related to airflow obstruction but not symptom control

Author

Ferreira, D. S., primary, Carvalho-Pinto, R. M., additional, Gregório, M. G., additional, Annoni, R., additional, Teles, A. M., additional, Buttignol, M., additional, Araújo-Paulino, B. B., additional, Katayama, E. H., additional, Oliveira, B. L., additional, Del Frari, H. S., additional, Cukier, A., additional, Dolhnikoff, M., additional, Stelmach, R., additional, Rabe, K. F., additional, and Mauad, T., additional

Published
2017
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48. Collagen I, III and IV content in airways and lung parenchyma of COPD patients

Author

Annoni, R, Lancas, T, Fernezlian, S, Silva, L, Bruno, A, Dolhnikoff, M, Hiemstra, P, Sterk, P, Rabe, K, Mauad, T., BATTAGLIA, Salvatore, Annoni, R, Lancas, T, Fernezlian, S, Silva, L, Bruno, A, Battaglia, S, Dolhnikoff, M, Hiemstra, P, Sterk, P, Rabe, K, and Mauad, T

Subjects
BPCO, Settore MED/10 - Malattie Dell'Apparato Respiratorio
Published
2010

49. Expression of versican in large and small airways and parenchima in lungs of non-smokers smokers and COPD patients

Author

Annoni, R, Lancas, T, Silva, L, Dolhnikoff, M, Bruno, A, Fernezlian, S, Hiemstra, P, Sterk, P, Rabe, K, Mauad, T., BATTAGLIA, Salvatore, Annoni, R, Lancas, T, Battaglia, S, Silva, L, Dolhnikoff, M, Bruno, A, Fernezlian, S, Hiemstra, P, Sterk, P, Rabe, K, and Mauad, T

Subjects
COPD, Smokers, small airway, Settore MED/10 - Malattie Dell'Apparato Respiratorio
Published
2009

50. Immune cell profile in infants' lung tissue

Author

Santos, A.B.G. dos, Binoki, D., Silva, L.F.F., Araujo, B.B. de, Otter, I. den, Annoni, R., Tsokos, M., Stein, R.T., Hiemstra, P.S., Rabe, K.F., Debertin, A., Tschernig, T., and Mauad, T.

Subjects
Mast cells, Infant, Autopsy, Lymphocytes, Dendritic cells
Published
2013

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