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2. Novel analgesic-antiinflammatory salicylates.

Author

Hannah J, Ruyle WV, Jones H, Matzuk AR, Kelly KW, Witzel BE, Holtz WJ, Houser RA, Shen TY, and Sarett LH

Subjects
Animals, Chemical Phenomena, Chemistry, Dogs, Rats, Salicylates pharmacology, Structure-Activity Relationship, Anti-Inflammatory Agents, Non-Steroidal chemical synthesis, Salicylates chemical synthesis
Abstract

5-(2,4-Difluorophenyl)salicylic acid, diflunisal (25), is the best compound, in terms of both efficacy and safety, from over 500 salicylates investigated in our laboratories. It is a chemically distinct, nonacetylating salicylic acid, more active than aspirin as an analgesic and antiinflammatory agent and superior in duration of action and therapeutic index. Some recent clinical and biochemical observations are briefly discussed.

Published
1978
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4. Antitubercular Diazine Carboxamides.

Author

Rogers EF, Leanza WJ, Becker HJ, Matzuk AR, O'neill RC, Basso AJ, Stein GA, Solotorovsky M, Gregory FJ, and Pfister K 3rd

Subjects
Niacin analogs & derivatives, Antitubercular Agents, Nicotinic Acids, Tuberculosis, Tuberculosis, Pulmonary
Published
1952
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