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1. Hypoplasia and neuronal immaturity of the hypoglossal nucleus in sudden infant death

Author

Ottaviani, G., Matturri, L., Mingrone, R., and Lavezzi, A.M.

Subjects
Sudden infant death syndrome -- Causes of, Sudden infant death syndrome -- Patient outcomes, Sudden infant death syndrome -- Case studies, Nerves, Cranial -- Physiological aspects, Neuroplasticity -- Research, Pneumonia in children -- Patient outcomes, Pneumonia in children -- Case studies, Health
Published
2006

2. Sudden infant death triggered by dive reflex

Author

Matturri, L., Ottaviani, G., and Lavezzi, A.M.

Subjects
Reflexes -- Evaluation, Reflexes -- Physiological aspects, Sudden infant death syndrome -- Causes of, Sudden infant death syndrome -- Case studies, Health
Published
2005

9. Third International Congress of Histochemistry and Cytochemistry

Author

Abe, Muneaki, Akamatsu, Masasuke, Matsumoto, Takaharu, Ohuchi, Nobuo, Masuya, Tomichi, Abe, T., Nakashio, K., Kazama, M., Matsuda, M., Adams, C. W. M., Virág, S., Morgan, R. S., Orton, C. C., Adams, Jean R., Wilcox, Theodore A., Akert, Konrad, Alberti, Rachele, Allen, Robert C., Moore, Dorothy J., Tyndall, Richard L., Anderson, Paul J., Song, Sun K., Angelakos, E. T., King, M. P., Appleton, Timothy C., Arstila, Antti U., Trump, Benjamin F., Lauria, A., Bahr, Gunter F., Wied, George L., Bartels, Peter H., Bajusz, E., Balogh, Kåroly, Barer, R., Barka, Tibor, Barnard, Eric A., Komender, Janusz, Wieckowski, Jan, Barrnett, R. J., Barron, K. D., Koeppen, A. H., Bernsohn, J., Bélanger, Leonard F., Beltrami, Carlo Alberto, Björklund, A., Ehinger, B., Falck, B., Boadle, Margaret C., Bloom, Floyd E., Bona, C., Bradshaw, M., Monus, L., Stroman, S., Budd, G. C., Salpeter, M. M., Bukhonova, A. I., Burnasheva, S. A., Jurzina, G. A., Burt, Alvin M., Chang, Jeffrey P., Schatzki, Peter F., Saito, Takuma, Chavin, Walter, Chyle, M., Korych, B., Lojda, Zdenek, Patocka, F., Cohn, Z. A., Conning, D. M., Coutinho, Hélio B., Rocha, Jácia T., Jales, Benjamin F., Cunningham, Lew, Heitsch, Richard, Daneholt, B., Edström, J.-E., Danilova, L. V., Rokhlenko, K. D., Dauwalder, M., Whaley, W. G., Kephart, J. E., Deitch, Arline D., Sawicki, Stanley G., Godman, Gabriel C., Della Corte, Francesco, Desmet, V. J., Bullens, A.-M., De Groote, J., Heirwegh, K. P. M., Diculescu, I., Onicescu, Doina, Szegly, G., Doane, Winifred W., Donskikh, N. V., Novikov, V. D., Subbotin, M. Ya., Tsirelnikov, N. I., Doolin, Paul F., Birge, Wesley J., Droz, Bernard, Bergeron, M., Drukker, J., Duarte-Escalante, Ovidio, Dubowitz, Victor, Dupraw, E. J., Eckner, Friedrich A. O., Blackstone, Eugene H., Moulder, Peter V., Ehrlich, M. P., Ellis, Stanley, McDonald, J. Ken, Callahan, P. X., Enesco, Hildegard E., Engel, W. King, Epifanova, O. I., Lomakina, L. Ya., Terskikh, V. V., Ericsson, Jan L. E., Jakobsson, Sten, Eristawi, K. D., Sharashidze, L. K., Sturua, N. S., Fabris, Guidalberto, Mariuzzi, Gianmario, Nenci, Italo, Fahimi, H. Dariush, Karnovsky, Morris J., Fand, Sally B., Farquhar, Marilyn G., Felgenhauer, K., Glenner, G. G., Stammler, A., Filkuka, J., Svejda, J., Áubrechtova, V., Filotto, U., Fischbein, J. W., Rutenburg, Alexander M., Fisher, Donald B., Forni, Alessandra, Nencioni, Torquato, Ballare’, Gianfranco, Fotin, Ludmila, Popescu, Maria, Frankfurt, O. S., Friend, Daniel S., Fuchs, B. B., Arutyunov, V. D., Shnaper, A. L., Gabunia, U. A., Shiukashvili, N. N., Gahan, P. B., Anker, P., Stroun, M., McLean, Jean, Galjaard, H., Bootsma, D., Ganina, K. P., Garcia, Alfredo Mariano, Garrett, J. R., Gepts, W., Gregoire, F., Ooms, H., Gerzeli, Giuseppe, Giacobini, Ezio, Hovmark, Stefan, Gilkerson, Seth W., Glick, David, Godlewski, H. G., Huszczuk, A., Penar, Barbara, Goldfischer, Sidney, Sternlieb, Irmin, Goldstone, A., Szabo, E., Koenig, Harold, Gornak, K. A., Goslar, H. G., Grigoriadis, P., Jaeger, K. H., Gössner, W., Benoit, H., Gracheva, Nina D., Grillo, T. Adesanya Ige, Gropp, A., Gross, U. M., Gueft, Boris, Guha, S., Fouquet, J. P., Håkanson, R., Owman, Ch., Sporrong, B., Hale, A. J., Marshall, D. J., Switsur, V. R., Hanker, Jacob S., Zenker, Nicolas, Morizono, Yoshihisa, Deb, Chandicharan, Seligman, Arnold M., Hardonk, M. J., Elema, J. D., Koudstaal, Joh., Hoedemaeker, Ph. J., Hayashi, Masando, Heller, A., Hernández, F., Martinez De Morentin, J., Herrmann, Hans-Jürgen, Hershey, Falls B., Hess, H. H., Pope, A., Bass, N. H., Hewitt, J. M., Guigon, M., Bolubasz, J., Himes, M. H., Burdick, C., Hirai, Kei-Ichi, Takamatsu, Hideo, Hirose, Shunta, Hirsch, Hilde E., Hodges, Donald R., Costoff, Allen, McShan, W. H., Holtzman, Eric, Holubar, K., Tappeiner, J., Wolff, K., Hopsu-Havu, Väinö K., Hosannah, Yvonne, Blackwood, Carlton E., Mandl, Ines, Hoskins, Godfrey C., Hugon, J. S., Borgers, M., Hurwitz, Lawrence S., Rubinstein, Lucien J., Ibrahim, M. Z. M., Imura, Shin-Ichi, Takeda, Masanori, Jacobsen, N. O., Jørgensen, P. Leth, Jarrett, A., Joandrea-Casian, Claudia, Prundeanu, Cornelia, Johnson, Anne B., Johnson, Waine C., Alkek, David S., Jongkind, J. F., Swaab, D. F., Jos, J., Junqueira, L. C., Toledo, A. M. Souza, Kaiser, Hans E., Kakari, Sophia, Kalina, Moshe, Bubis, Jose. J., Kamentsky, L. A., Kasten, Frederick H., Kiefer, Gunter G., Sandritter, W., Killander, D., Rigler, R., Kishino, Yasuo, Kobayashi, H., Urano, A., Yokoyama, K., Koelle, George B., Hughes, Charles, Korhonen, L. Kalevi, Kramer, M. F., Poort, C., Kreutzberg, Georg W., Künzel, Erich, Tanyolac, Attila, Labella, Frank S., Langley, O. K., Lanza, Giovanni B., Lappano-Colletta, Eleanor Rita, Leblond, C. P., Merzel, J., Cheng, Hazel, Nadler, N. J., Herscovics, Annette A., Lederer, B., Mittermayer, C., Lee, Sin Hang, Torack, Richard M., Lehrer, Gerard M., Bornstein, Murray B., Katzman, Robert, Leites, F. L., Tendetnik, Ju. J., Ruchadse, E. S., Rjadneva, O. E., Leppi, T. John, Kinnison, Patricia A., Gaffney, Susan P., Lev, Robert, Gerard, Andre, De Graef, Jacques, Jerzy Glass, George B., Lhotka, J. F., Jr., Anderson, J. W., Liber, Amour F., Lillie, R. D., Pizzolato, Philip, Lindner, J., Grasedyck, K., Johannes, G., Freytag, G., Lipchina, L. P., Aksyutina, M. S., Yablonovskaya, L. Ya., Lipetz, Jacques, Liu, J. C., Roizin, L., Lodin, Z., Kage, M., Hartman, J., Srajer, J., Fric, Premysl, Long, Margaret E., Sommers, Sheldon C., McGarry, E. E., Nayak, R., Birch, E., Beck, J. C., McMillan, Paul J., Adeoye, Christopher ’Seinde, Macovschi, O., Maeda, Ryuei, Ihara, Nobuo, Kanazawa, Kokichi, Maeir, David M., Wagner, Lenore, Maggi, Viviane, Franks, L. M., Livingston, D. C., Coombs, M. M., Wilson, Patricia D., Carbonell, A. W., Malyuk, V. I., Romanini, Manfredi, Gabriella, Maria, Fraschini, Annunzia, Porcelli, Franca, Manocha, Sohan L., Shantha, Totada R., Bourne, Geoffrey H., Marques, Dante, Bastos, A. L., Baptista, A. M., Vigario, J. D., Nunes, J. M., Terrinha, A. M., Silva, J. A. F., Masurovsky, E. B., Benitez, H. H., Kim, S-U., Murray, M. R., Matschinsky, F. M., Rutherford, C. L., Guerra, L., Matturri, L., Curri, S., Melnick, P. J., Mendelsohn, M. L., Conway, T. J., Perry, B., Prewitt, J. M. S., Mercado, Teresa I., Miksche, Jerome P., Misch, Donald W., Misch, Margaret S., Mitchell, J. P., Mizuhira, Vinci, Uchida, Kazuko, Amakawa, Takanori, Shindo, Hideo, Totsu, Junichi, Suesada, Ikuo, Mizutani, Akira, Monis, Benito, Candiotti, Alberto, Mori, G., Ingrami, A., Morikawa, Shigeru, Yamamura, Masao, Harada, Takayuki, Hamashima, Yoshihiro, Mullaney, P. F., Dean, P. N., Van Dilla, M. A., Müller, Gerhard, Müller, Otfried, Nakane, Paul K., Neurath, Peter W., Curtis, Zay B., Selles, William, Vetter, Henri G., Norgren, P. E., Novikoff, Alex B., O’Brien, Regina, Ohringer, Philip, Spitaleri, Vincent, Olszewska, M. J., Gabara, B., Konopska, L., Parfanovich, M. I., Sokolov, N. N., Berezina, O. N., Fadeeva, L. L., Pauly, John E., Scheving, Lawrence E., Pearse, A. G. E., Pearson, Bjarne, Bennett, William, Esterly, John R., Standen, Alfred C., Pelc, S. R., Viola-Magni, M. P., Penttilä, Antti, Perez, Vernon J., Moore, Blake W., Peters, Theodore, Jr., Danzi, J. Thomas, Ashley, Charles A., Petrova, A. S., Probatova, N. A., Philippens, Karel, Pilgrim, C., Pollock, B. M., Presnov, M. A., Preston, Kendall, Jr., Preto Parvis, V., Cisotti, F., Prewitt, Judith M. S., Mayall, Brian H., Mendelsohn, Mortimer L., Pryse-Davis, John, Sandler, Merton, Quay, W. B., Raikhlin, N. T., Rasch, Ellen M., Riecken, E. O., Goebell, H., Bode, C., Rigatuso, Joseph L., Ringertz, N. R., Bolund, L., Ritter, Carl, Thorell, Bo, Rizzotti, M., Aureli, G., Balduini, C., Castellani, A. A., Rosenbaum, Robert M., Rosene, Gordon L., Rossi, Ferdinando, Rost, F. W. D., Roth, Daniel, Ruch, Fritz, Ruddle, Frank H., Lubs, Herbert A., Ledley, Robert S., Shows, Thomas B., Roderick, Thomas H., Kim, H., Brodie, E., Rosales, C. L., Sadauskas, P., Luksys, L., Dabkevcius, V., Sakharova, A. V., Sakharov, D. A., Samosudova, N. V., Ogieveckaja, M. M., Kalamkarova, M. B., Sandler, Maurice, Santti, R. S., Sasaki, Mitsuo, Takeuchi, Tadao, Satir, P., Schauer, Alfred, Scher, Stanley, Haley, Patricia L., Schiebler, T. H., Schiemer, Hans-Georg, Schlüns, Jürgen, Schuster, F. L., Hershenov, B., Scott, J. E., Scott, T. Gilbert, Seno, Satimaru, Yokomura, Ei-Ichi, Itoh, Nobutaka, Yamamoto, Michio, Shungskaya, V. E., Enenko, S. O., Lukyanova, L. D., Sarch, E. N., Shuter, Eli, Jungalwala, Firoze, Robins, Eli, Sierakowska, Halina, Silverman, L., Simard, A., Daoust, R., Smith, Edgar E., Smith, R. E., Fishman, William H., Henzl, Milan, Sobel, Harold J., Avrin, Erna, Sorokin, Helen P., Sorokin, Sergei, Squier, C. A., Waterhouse, J. P., Steinbach, Günter, Steplewski, Zenon, Stitnimankarn, Tinrat, Stoward, Peter J., Straus, W., Stumpf, Walter E., Roth, Lloyd J., Sylvén, B., Kanamura, Shinsuke, Templeton, McCormick, Tewari, H. B., Tyagi, H. R., Thalmann, R., Glismann, L., Thomas, E., Tice, Lois W., Tixier-Vidal, A., Törö, I., Bacsy, E., Vadasz, Gy., Rappay, Gy., Tsou, K. C., Chang, Mildred Y., Matsukawa, S., Goodwin, Cleon, Lynm, Dwo, Seamond, Bette, Van Der Ploeg, M., Van Duijn, P., Coulter, J. R., Pascoe, E., Van Fleet, D. S., VanHouten, Wiecher H., Vecher, A. S., Masko, A. A., Predkel, K. I., Reshetnikov, V. N., Tchaika, M. T., Velican, C., Velican, Doina, Vendrely, C., Lageron, A., Tournier, P., Vialli, Maffo, Prenna, Giovanni, Vilter, Voldemar, Vittek, Josef, Vogt, Arnold, Vollrath, L., Von Mayersbach, Heinz, Vorbrodt, Andrzej, Wächtler, Klaus, Wakabayashi, Katsumi, Tamaoki, Bun-Ichi, Wald, Niel, Ranshaw, Russell, Weller, Roy O., Welsch, Ulrich, Werner, Gottfried, Williams, Vick, Morriss, Fran, Willighagen, R. G. J., Wilson, Barry W., Wohlrab, Frank, Wolf, Paul L., Horwitz, Jerome P., Freisler, Josef V., Von Der Muehll, Elisabeth, Vazquez, Janice, Wolman, Moshe, Yamada, Masaoki, Iwata, Sunao, Yamaguchi, Hisao, Yataganas, X., Gahrton, G., Young, Ian T., Zaccheo, D., Grossi, C. E., Genta, V., Riva, A., Zacks, S. I., Sheff, M. F., Zamfirescu-Gheorghiu, M., Serban, M., Vladescu, C., Chirulescu, Z., Marcus, N., Zelenin, A. V., Kirianova, E. A., Stepanova, N. G., Zeuthen, Erik, Zimmermann, Horst, Zugibe, Frederick T., Abrahamson, Dean E., Anderson, Norman G., Caspersson, Törbjorn, Cornell, Richard, Dougherty, William, Jirasek, J. E., Jonsson, Gösta, Leske, Regina, Moyer, Frank H., Schneider, Walter C., Siegel, Howard I., Sternberger, Ludwig, Osserman, Elliott F., Weinstock, A., and Rosenbaum, Robert M.

Published
1968
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11. Sudden Infant Death With Area Postrema Lesion Likely Due to Wrong Use of Insecticide

Author

Lavezzi, A, Cappiello, A, Termopoli, V, Bonoldi, E, Matturri, L, Lavezzi, Anna M., CAPPIELLO, ACHILLE, TERMOPOLI, VERONICA, Bonoldi, Emanuela, Matturri, Luigi, Lavezzi, A, Cappiello, A, Termopoli, V, Bonoldi, E, Matturri, L, Lavezzi, Anna M., CAPPIELLO, ACHILLE, TERMOPOLI, VERONICA, Bonoldi, Emanuela, and Matturri, Luigi

Abstract

We report a noteworthy case of a 7-month-old infant who suddenly and unexpectedly died during her sleep. After a complete postmortem examination, review of the clinical history, and detailed death scene investigation, the death remained unexplained, leading to a diagnosis of sudden infant death syndrome. However, an extensive review of the brainstem neuropathology revealed a severe alteration in the area postrema (a highly vascular structure lying at the base of the fourth ventricle outside of the blood-brain barrier). The alteration was likely due to massive and repeated to a common household insecticide in the last few weeks of life. These results provide an explanation for this sudden infant death, allowing a differential diagnosis from sudden infant death syndrome.

Published
2015

12. Obstructive hypertrophic cardiomyopathy in type III glycogen-storage disease

Author

Cuspidi, C, Sampieri, L, Pelizzoli, S, Pontiggia, G, Zanchetti, A, Nappo, A, Caputo, V, Matturri, L, CUSPIDI, CESARE, Matturri, L., Cuspidi, C, Sampieri, L, Pelizzoli, S, Pontiggia, G, Zanchetti, A, Nappo, A, Caputo, V, Matturri, L, CUSPIDI, CESARE, and Matturri, L.

Abstract

We present here a rare case of a patient affected by hypertrophic obstructive cardiomyopathy related to type III glycogenosis. In this patient the correct diagnosis could only be performed by endomyocardial biopsy

Published
1998

13. Developmental alterations of the spinal trigeminal nucleus disclosed by substance P immunohistochemistry in fetal and infant sudden unexplained deaths

Author

Lavezzi, A. M., Mehboob, Riffat, and Matturri, L.

Subjects
Pregnancy, SIDS, Infant, Newborn, Humans, Infant, Spinal trigeminal nucleus, Female, Substance P, Trigeminal Nucleus, Spinal, Sudden fetal death, Fetal Death, Neuropathology, Sudden Infant Death
Abstract

We investigated the immunohistochemical expression of substance P (SP) in the brainstems of 56 subjects aged from 17 gestational weeks to 10 post natal months, who died of unknown (sudden unexplained fetal deaths and SIDS) and known causes (controls). The goals of this study were: (i) to obtain basic information about the expression of SP during the first phases of human nervous system development; (ii) to evaluate whether there are alterations of this neuromodulator in victims of sudden death; and (iii) to verify any correlation with maternal cigarette smoking. Immunohistochemistry demonstrated SP immunoreactivity in the caudal trigeminal nucleus area, with a progressive increase in the density of SP-positive fibers of the corresponding tract during normal development from fetal life to the first post natal months. Delineation of the structure of the human trigeminal nucleus, little investigated so far, provided essential data on its morphologic and functional development. Instead, a negative or low SP expression was detectable in the fibers of this tract in a wide subset of SIDS victims and, conversely, a high SP-expression in a wide subset of sudden fetal deaths. We postulate, on the basis of these results, that SP has a functional importance in the early phases of central nervous system development and in the regulation of autonomic functions. In addition, the observation of a significant correlation between sudden unexplained death, altered SP staining and maternal smoking leads us to suggest a close relation between the absorption of cigarette smoke in utero and a decreased functional activity of the trigeminal nucleus, that can trigger sudden death of the fetus during pregnancy or of the infant in the first months of life.

Published
2011

15. Determination of Selected Endocrine Disrupting Compounds in Human Fetal and Newborn Tissues by GC-MS

Author

Cappiello, A, Famiglini, G, Palma, P, Termopoli, V, Lavezzi, A, Matturri, L, Lavezzi, AM, Cappiello, A, Famiglini, G, Palma, P, Termopoli, V, Lavezzi, A, Matturri, L, and Lavezzi, AM

Abstract

Endocrine disrupting compounds (EDCs) include organochlorine pesticides (OCPs), organophosphate pesticides (OPPs), carbamate pesticides, and plasticizers, such as bisphenol A (BPA). They persist in the environment because of their degradation resistance and bioaccumulate in the body tissues of humans and other mammals. Many studies are focused on the possible correlation between in utero exposure to EDCs and adverse health hazards in fetuses and newborns. In the last decade, environmental pollution has been considered a possible trigger for Sudden Infant Death Syndrome (SIDS) and Sudden Intrauterine Unexplained Death Syndrome (SIUDS), the most important death-causing syndromes in fetuses and newborns in developed countries. In this work, a rapid and sensitive analytical method was developed to determine the level of OCPs and OPPs, carbamates, and phenols in human fetal and newborn tissues (liver and brain) and to unveil the possible presence of non-targeted compounds. The target analytes where selected on the basis of their documented presence in the Trentino-Alto Adige region, an intensive agricultural area in northern Italy. A liquid-solid extraction procedure was applied on human and animal tissues and the extracts, after a solid phase extraction (SPE) clean-up procedure, were analyzed by gas chromatography coupled to a quadrupole mass spectrometric detector (GC-qMS). A GC-TOFMS (time-of-flight) instrument, because of its higher full-scan sensitivity, was used for a parallel detection of non-targeted compounds. Method validation included accuracy, precision, detection, and quantification limits (LODs; LOQs), and linearity response using swine liver and lamb brain spiked at different concentrations in the range of 0.4-8000.0 ng/g. The method gave good repeatability and extraction efficiency.Method LOQs ranged from0.4-4.0 ng/g in the selectedmatrices. Good linearity was obtained over four orders of magnitude starting from LOQs. Isotopically labeled internal standar

Published
2014

16. Sudden infant death following hexavalent vaccination: A neuropathologic study

Author

Matturri, L, DEL CORNO, G, Lavezzi, A, Lavezzi, A., DEL CORNO, GIAN GIUSEPPE, Matturri, L, DEL CORNO, G, Lavezzi, A, Lavezzi, A., and DEL CORNO, GIAN GIUSEPPE

Abstract

We examined a large number of sudden infant death syndrome victims in order to point out a possible causal relationship between a previous hexavalent vaccination and the sudden infant death. We selected 110 cases submitted to in-depth histological examination of the autonomic nervous system and provided with detailed clinical and environmental information. In 13 cases (11.8%) the death occurred in temporal association with administration of the hexavalent vaccine (from 1 to 7 days). In none of these victims congenital developmental alterations of the main nervous structures regulating the vital functions were observed. Only the hypoplasia of the arcuate nucleus was present in 5 cases. In one case in particular an acquired hyperacute encephalitis of the tractus solitarii nucleus was diagnosed in the brainstem. This study does not prove a causal relationship between the hexavalent vaccination and SIDS. However, we hypothesize that vaccine components could have a direct role in sparking off a lethal outcome in vulnerable babies. In conclusion, we sustain the need that deaths occurring in a short space of time after hexavalent vaccination are appropriately investigated and submitted to a post-mortem examination particularly of the autonomic nervous system by an expert pathologist to objectively evaluate the possible causative role of the vaccine in SIDS., We examined a large number of sudden infant death syndrome victims in order to point out a possible causal relationship between a previous hexavalent vaccination and the sudden infant death. We selected 110 cases submitted to in-depth histological examination of the autonomic nervous system and provided with detailed clinical and environmental information. In 13 cases (11.8%) the death occurred in temporal association with administration of the hexavalent vaccine (from 1 to 7 days). In none of these victims congenital developmental alterations of the main nervous structures regulating the vital functions were observed. Only the hypoplasia of the arcuate nucleus was present in 5 cases. In one case in particular an acquired hyperacute encephalitis of the tractus solitarii nucleus was diagnosed in the brainstem. This study does not prove a causal relationship between the hexavalent vaccination and SIDS. However, we hypothesize that vaccine components could have a direct role in sparking off a lethal outcome in vulnerable babies. In conclusion, we sustain the need that deaths occurring in a short space of time after hexavalent vaccination are appropriately investigated and submitted to a post-mortem examination particularly of the autonomic nervous system by an expert pathologist to objectively evaluate the possible causative role of the vaccine in SIDS. © 2014 Bentham Science Publishers.

Published
2014

18. Methemoglobin as The Biomarker Of Environmental Oxidants And Precursor Of Adverse Effcts Of Oxidative Stress On Mother And Fetus- Reasons For Its Early Detection And Therapy

Author

Mohorović, Lucijan and Matturri L.

Subjects
methemoglobin, environmental oxidants
Abstract

Methemoglobin (MetHb) and its catabolic products are prooxidant. In the first blood circulation stage, the inhalation of nitrogen oxides transforms the hemoglobin into its pathological MetHb. Methemoglobinemia symptoms in "maternal preeclampsia" are also common in severe anemia, preeclampsia and eclampsia, suggesting them to be a precursor for these conditions. The oxidants crossing the placental barrier cause "fetal preeclampsia". The levels of MetHb and its catabolic products as bilirubin-biliverdin, CO and toxic Fe (III) with paramagnetic nature probably go over to BBB and provoke adverse effects on brain development. The objective is to confirm the anatomo-pathological and genetic alterations that underlie sudden unexpected and unexplained perinatal and infant death and their correlation with environmental factors. The MetHb level was determined from the samples that were taken three times, with a one-month pause between each test, for each pregnant woman (N=122) in the exposure period of power plant operation and in the control period when the power plant was closed (N=138). The significant positive correlation between the level of MetHb and the daily ground level concentration of SO2 was found (r=0.72, pcontrol< (N=4) and >exposure< periods (N=10) (p=0.0369) and the frequency of stillbirths with the amount of MetHb >1.5 g/L in the exposure period was also statistically significant (p=0.0336). The test of chromosome aberration (SCI) was not significant in newborns whose mothers' MetHb level was >1.5 g/L (N=36). We observed them by collecting data from hospitals, preschool and school services at health centers until they were eighteen years of age, and we found that the incidences of neonatal jaundice (p=0.034), later heart murmur (p=0.011) and dyslalia and learning / memory impairments (p=0.002) were significantly higher than in children born by control mothers (n=19). The MetHb level is a useful biomarker but also has a degree of predictive validity. Our current research intends to study the brain morphological aspects of the development of both the autonomic nervous system and the cardiac conduction system and to individuate the environmental interactions resulting in the perinatal unexplained death, as well as to help find therapy, especially in underdeveloped countries with high maternal and perinatal morbidity and mortality.

Published
2008

19. Peripheral chemoreceptors, postnatal development and cytochemical findings in Sudden Infant Death Syndrome

Author

Porzionato, A., VERONICA MACCHI, Parenti, A., Matturri, L., and Caro, R.

Subjects
616 - Patología. Medicina clínica. Oncología, Carotid body, Sudden infant death syndrome
Abstract

The aim of the present study is to give a review of the postnatal development of peripheral chemoreceptors - carotid body, paraganglia, and pulmonary neuroendocrine cells (PNEC) - with implications in Sudden Infant Death Syndrome (SIDS). In the postnatal period, the hypoxic chemosensitivity of the carotid body gradually develops. Changes include proliferation of type I and II cells, increased numbers of dense core vesicles and K+ channels, and modifications of neurotransmitter/neuromodulator and receptor expression. Chromaffin paraganglia show increased expression of nitric oxide synthase and neuropeptides, and increased innervation. Innervation of PNEC develops fully only in the first postnatal period, after which their density falls. The neuropeptides produced by PNEC also changes, with increased expression of calcitonin gene-related peptide and neuropeptide YY and reduced expression of calcitonin and gastrin-releasing peptide. Most of the findings in the carotid body of SIDS victims, i.e., decrease in type I cells and dense cytoplasmic granules, and increase in progenitor cells, indicates immaturity of the carotid body, which may play a role in SIDS in the form of underlying biologic vulnerability. Aorticopulmonary paraganglia hyperplasia and increase of PNEC are also found in SIDS, and may be epiphenomena of alterations of the respiratory function with a pathogenetical role in SIDS. A comprehensive view of the pathogenesis of SIDS should also arise from the integration of peripheral chemoreceptors findings with neuro- and cardiopathologic ones.

Published
2008

20. Third International Congress of Histochemistry and Cytochemistry

Author

Muneaki, Abe, primary, Akamatsu, Masasuke, additional, Matsumoto, Takaharu, additional, Ohuchi, Nobuo, additional, Masuya, Tomichi, additional, Abe, T., additional, Nakashio, K., additional, Kazama, M., additional, Matsuda, M., additional, Adams, C. W. M., additional, Virág, S., additional, Morgan, R. S., additional, Orton, C. C., additional, Adams, Jean R., additional, Wilcox, Theodore A., additional, Akert, Konrad, additional, Alberti, Rachele, additional, Allen, Robert C., additional, Moore, Dorothy J., additional, Tyndall, Richard L., additional, Anderson, Paul J., additional, Song, Sun K., additional, Angelakos, E. T., additional, King, M. P., additional, Appleton, Timothy C., additional, Arstila, Antti U., additional, Trump, Benjamin F., additional, Aureli, G., additional, Lauria, A., additional, Rizzotti, M., additional, Bahr, G. F., additional, Wied, G. L., additional, Bartels, P., additional, Bajusz, E., additional, Barer, R., additional, Barka, Tibor, additional, Barnard, Eric A., additional, Komender, Janusz, additional, Wieckowski, Jan, additional, Barrnett, R. J., additional, Barron, K. D., additional, Koeppen, A. H., additional, Bernsohn, J., additional, Bélanger, Leonard F., additional, Beltrami, Carlo Alberto, additional, Björklund, A., additional, Ehinger, B., additional, Falck, B., additional, Boadle, Margaret C., additional, Bloom, Floyd E., additional, Bona, C., additional, Bradshaw, M., additional, Stroman, S., additional, Monus, L., additional, Budd, G. C., additional, Salpeter, M. M., additional, Bukhonova, A. I., additional, Burnasheva, S. A., additional, Jurzina, G. A., additional, Burt, Alvin M., additional, Chang, Jeffre Y. P., additional, Schatzki, Peter F., additional, Saito, Takuma, additional, Chavin, Walter, additional, Chyle, M., additional, Korych, B., additional, Lojda, Z., additional, Patocka, F., additional, Cohn, Z. A., additional, Conning, D. M., additional, Coutinho, Hélio B., additional, Rocha, Jácia T., additional, Jales, Benjamin F., additional, Cunningham, Lew, additional, Heitsch, Richard, additional, Daneholt, B., additional, Edström, J.-E., additional, Danilova, L. V., additional, Rokhlenko, K. D., additional, Dauwalder, M., additional, Whaley, W. G., additional, Kephart, J. E., additional, Deitch, Arline D., additional, Sawicki, Stanley G., additional, Godman, Gabriel C., additional, Francesco, Della Corte, additional, Desmet, V. J., additional, Bullens, A.-M., additional, De Groote, J., additional, Heirwegh, K. P. M., additional, Diculescu, I., additional, Onicescu, Doina, additional, Szegly, G., additional, Doane, Winifred W., additional, Donskikh, N. V., additional, Novikov, V. D., additional, Subbotin, M. Ya., additional, Tsirelnikov, N. I., additional, Doolin, Paul F., additional, Birge, Wesley J., additional, Bernard, Droz, additional, Droz, B., additional, Bergeron, M., additional, Drukker, J., additional, Duarte-Escalante, Ovidio, additional, Dubowitz, Victor, additional, Dupraw, E. J., additional, Eckner, Friedrich A. O., additional, Blackstone, Eugene H., additional, Moulder, Peter V., additional, Ehrlich, M. P., additional, Stanley, Ellis, additional, McDonald, J. Ken, additional, Callahan, P. X., additional, Epifanova, O. I., additional, Lomakina, L. Ya., additional, Terskikh, V. V., additional, Ericsson, Jan L. E., additional, Jakobsson, Sten, additional, Eristawi, K. D., additional, Sharashidze, L. K., additional, Sturua, N. S., additional, Fabris, G., additional, Mariuzzi, G. M., additional, Nenci, I., additional, Fahimi, Dariush H., additional, Karnovsky, Morris J., additional, Fand, Sally B., additional, Farquhar, Marilyn G., additional, Felgenhauer, K., additional, Glenner, G. G., additional, Stammler, A., additional, Filkuka, J., additional, Svejda, J., additional, Áubrechtova, V., additional, Filotto, U., additional, Fischbein, J. W., additional, Rutenburg, A. M., additional, Fisher, Donald B., additional, Alessandra, Forni, additional, Nencioni, Torquato, additional, Ballare, Gianfranco, additional, Ludmila, Fotin, additional, Popescu, Maria, additional, Frankfurt, O. S., additional, Friend, Daniel S., additional, Fuchs, B. B., additional, Arutyunov, V. D., additional, Shnaper, A. L., additional, Gabunia, U. A., additional, Shiukashvili, N. N., additional, Gahan, P. B., additional, Anker, P., additional, Stroun, M., additional, McLean, Jean, additional, Galjaard, H., additional, Bootsma, D., additional, Ganina, K. P., additional, Garcia, Alfredo Mariano, additional, Garrett, J. R., additional, Gepts, W., additional, Gregoire, F., additional, Ooms, H., additional, Giuseppe, Gerzeli, additional, Ezio, Giacobini, additional, Hovmark, Stefan, additional, Gilkerson, Seth W., additional, David, Glick, additional, Godlewski, H. G., additional, Huszczuk, A., additional, Penar, Barbara, additional, Goldfischer, Sidney, additional, Sternlieb, Irmin, additional, Goldstone, A., additional, Szabo, E., additional, Koenig, H., additional, Gornak, K. A., additional, Goslar, H. G., additional, Grigoriadis, P., additional, Jaeger, K. H., additional, Gössner, W., additional, Benoit, H., additional, Gracheva, Nina D., additional, Grillo, T. Adesanya Ige, additional, Gropp, A., additional, Gross, U. M., additional, Gueft, Boris, additional, Guha, S., additional, Fouquet, J. P., additional, Håkanson, R., additional, Owman, Ch., additional, Sporrong, B., additional, Hale, A. J., additional, Marshall, D. J., additional, Switsur, V. R., additional, Hanker, Jacob S., additional, Zenker, Nicolas, additional, Morizono, Yoshihisa, additional, Deb, Chandicharan, additional, Seligman, Arnold M., additional, Hardonk, M. J., additional, Elema, J. D., additional, Koudstaal, Joh, additional, Hoedemaeker, Ph. J., additional, Hayashi, Masando, additional, Heller, A., additional, Hernández, F., additional, De Morentin, J. Martinez, additional, Hans-Jürgen, Herrmann, additional, Hershey, Falls B., additional, Hess, H. H., additional, Pope, A., additional, Bass, N. H., additional, Hewitt, J. M., additional, Guigon, M., additional, Bolubasz, J., additional, Himes, M. H., additional, Burdick, C., additional, Hirai, Kei-Ichi, additional, Takamatsu, Hideo, additional, Shunta, Hirose, additional, Hirsch, Hilde E., additional, Hodges, Donald R., additional, Costoff, Allen, additional, McShan, W. H., additional, Holtzman, Eric, additional, Holubar, K., additional, Tappeiner, J., additional, Wolff, K., additional, Hopsu-Havu, Vainö K., additional, Hosannah, Yvonne, additional, Blackwood, Carlton E., additional, Mandl, Ines, additional, Hoskins, Godfrey C., additional, Hugon, J. S., additional, Borgers, M., additional, Hurwitz, Lawrence S., additional, Rubinstein, Lucien J., additional, Ibrahim, M. Z. M., additional, Imura, Shin-Ichi, additional, Takeda, Masanori, additional, Jacobsen, N. O., additional, Jørgensen, P. Leth, additional, Jarrett, A., additional, Claudia, Joandrea-Casian, additional, Prundeanu, Cornelia, additional, Johnson, Anne B., additional, Johnson, Waine C., additional, Alkek, David S., additional, Jongkind, J. F., additional, Swaab, D. F., additional, Jos, J., additional, Junqueira, L. C., additional, Toledo, A. M. Souza, additional, Kaiser, Hans E., additional, Kakari, Sophia, additional, Kalina, Moshe, additional, Bubis, Jose. J., additional, Kamentsky, L. A., additional, Kasten, Frederick H., additional, Kiefer, Gunter G., additional, Sandritter, W., additional, Killander, D., additional, Rigler, R., additional, Yasuo, Kishino, additional, Kobayashi, H., additional, Urano, A., additional, Yokoyama, K., additional, Koelle, George B., additional, Koenig, Harold, additional, Hughes, Charles, additional, Korhonen, Kalevi L., additional, Kramer, M. F., additional, Poort, C., additional, Kreutzberg, Georg W., additional, Künzel, Erich, additional, Tanyolac, Attila, additional, Labella, Frank S., additional, Langley, O. K., additional, Lanza, Giovanni B., additional, Lappano-Colletta, Eleanor Rita, additional, Leblond, C. P., additional, Merzel, J., additional, Cheng, Hazel, additional, Nadler, N. J., additional, Herscovics, Annette A., additional, Lederer, B., additional, Mittermayer, C., additional, Lee, Sin Hang, additional, Torack, Richard M., additional, Lehrer, Gerard M., additional, Bornstein, Murray B., additional, Katzman, Robert, additional, Leites, F. L., additional, Tendetnik, Ju. J., additional, Ruchadse, E. S., additional, Rjadneva, O. E., additional, Leppi, T. John, additional, Kinnison, Patricia A., additional, Gaffney, Susan P., additional, Lev, Robert, additional, Gerard, Andre, additional, de Graef, Jacques, additional, Glass, George B. Jerzy, additional, Lhotka, J. F., additional, Anderson, J. W., additional, Liber, Amour F., additional, Lillie, R. D., additional, Pizzolato, Philip, additional, Lindner, J., additional, Grasedyck, K., additional, Johannes, G., additional, Freytag, G., additional, Gries, G., additional, Lipchina, L. P., additional, Aksyutina, M. S., additional, Yablonovskaya, L. Ya., additional, Lipetz, Jacques, additional, Liu, J. C., additional, Roizin, L., additional, Lodin, Z., additional, Kage, M., additional, Hartman, J., additional, Srajer, J., additional, Lojda, Zdenek, additional, Fric, Premysl, additional, Long, Margaret E., additional, Sommers, Sheldon C., additional, Ken, McDonald J., additional, Ellis, Stanley, additional, McGarry, E. E., additional, Nayak, R., additional, Birch, E., additional, Beck, J. C., additional, McMillan, Paul J., additional, Adeoye, Christopher ’Seinde, additional, Macovschi, O., additional, Maeda, Ryuei, additional, Ihara, Nobuo, additional, Kanazawa, Kokichi, additional, Maeir, David M., additional, Wagner, Lenore, additional, Viviane, Maggi, additional, Franks, L. M., additional, Livingston, D. C., additional, Coombs, M. M., additional, Wilson, Patricia D., additional, Carbonell, A. W., additional, Malyuk, V. I., additional, Romanini, Manfredi, additional, Gabriella, Maria, additional, Fraschini, Annunzia, additional, Porcelli, Franca, additional, Manocha, Sohan L., additional, Shantha, Totada R., additional, Bourne, Geoffrey H., additional, Marques, Dante, additional, Bastos, A. L., additional, Baptista, A. M., additional, Vigario, J. D., additional, Nunes, J. M., additional, Terrinha, A. M., additional, Silva, J. A. F., additional, Masurovsky, E. B., additional, Benitez, H. H., additional, Kim, S-U., additional, Murray, M. R., additional, Matschinsky, F. M., additional, Rutherford, C. L., additional, Guerra, L., additional, Matturri, L., additional, Curri, S., additional, Mayall, Brian H., additional, Melnick, P. J., additional, Mendelsohn, M. L., additional, Conway, T. J., additional, Perry, B., additional, Prewitt, J. M. S., additional, Mercado, Teresa I., additional, Miksche, Jerome P., additional, Misch, Donald W., additional, Misch, Margaret S., additional, Mitchell, J. P., additional, Kiefer, G., additional, Mizuhira, Vinci, additional, Uchida, Kazuko, additional, Amakawa, Takanori, additional, Shindo, Hideo, additional, Totsu, Junichi, additional, Suesada, Ikuo, additional, Mizutani, Akira, additional, Monis, Benito, additional, Candiotti, Alberto, additional, Mori, G., additional, Ingrami, A., additional, Morikawa, Shigeru, additional, Yamamura, Masao, additional, Harada, Takayuki, additional, Hamashima, Yoshihiro, additional, Mullaney, P. F., additional, Dean, P. N., additional, Van Dilla, M. A., additional, Müller, Gerhard, additional, Müller, Otfried, additional, Nakane, Paul K., additional, Neurath, Peter W., additional, Curtis, Zay B., additional, Selles, William, additional, Vetter, Henri G., additional, Norgren, P. E., additional, Novikoff, Alex B., additional, Regina, O‘brien, additional, Ohringer, Philip, additional, Spitaleri, Vincent, additional, Olszewska, M. J., additional, Gabara, B., additional, Konopska, L., additional, Parfanovich, M. I., additional, Sokolov, N. N., additional, Berezina, O. N., additional, Fadeeva, L. L., additional, Pauly, John E., additional, Scheving, Lawrence E., additional, Pearse, A. G. E., additional, Pearson, Bjarne, additional, Bennett, William, additional, Esterly, John R., additional, Standen, Alfred C., additional, Pelc, S. R., additional, Viola-Magni, M. P., additional, Antti, Penttilä, additional, Perez, Vernon J., additional, Moore, Blake W., additional, Peters, Theodore, additional, Danzi, J. Thomas, additional, Ashley, Charles A., additional, Petrova, A. S., additional, Probatova, N. A., additional, Philippens, Karel, additional, Pilgrim, C., additional, Pollock, B. M., additional, Presnov, M. A., additional, Preston, Kendall, additional, Preto, V. Parvis, additional, Cisotti, F., additional, Mazza, G. E., additional, Prewitt, Judith M. S., additional, Mendelsohn, Mortimer L., additional, Pryse-Davis, John, additional, Sandler, Merton, additional, Quay, W. B., additional, Raikhlin, N. T., additional, Rasch, Ellen M., additional, Riecken, E. O., additional, Goebell, H., additional, Bode, C., additional, Rigatuso, Joseph L., additional, Ringertz, N. R., additional, Bolund, L., additional, Carl, Ritter, additional, Thorell, Bo, additional, Balduini, C., additional, Castellani, A. A., additional, Rosenbaum, Robert M., additional, Rosene, Gordon L., additional, Rossi, Ferdinando, additional, Rost, F. W. D., additional, Roth, Daniel, additional, Ruch, Fritz, additional, Ruddle, Frank H., additional, Lubs, Herbert A., additional, Ledley, Robert S., additional, Shows, Thomas B., additional, Roderick, Thomas H., additional, Kim, H., additional, Brodie, E., additional, Fischbein, J., additional, Rosales, C. L., additional, Sadauskas, P., additional, Luksys, L., additional, Dabkevcius, V., additional, Sakharova, A. V., additional, Sakharov, D. A., additional, Samosudova, N. V., additional, Ogieveckaja, M. M., additional, Kalamkarova, M. B., additional, Sandler, Maurice, additional, Santti, R. S., additional, Hopsu-Havu, V. K., additional, Sasaki, Mitsuo, additional, Takeuchi, Tadao, additional, Satir, P., additional, Schauer, Alfred, additional, Scher, Stanley, additional, Haley, Patricia L., additional, Schiebler, T. H., additional, Schiemer, Hans-Georg, additional, Schlüns, Jürgen, additional, Schuster, F. L., additional, Hershenov, B., additional, Scott, J. E., additional, Scott, T. Gilbert, additional, Seno, Satimaru, additional, Yokomura, Ei-ichi, additional, Itoh, Nobutaka, additional, Yamamoto, Michio, additional, Shungskaya, V. E., additional, Enenko, S. O., additional, Lukyanova, L. D., additional, Sarch, E. N., additional, Eli, Shuter, additional, Jungalwala, Firoze, additional, Robins, Eli, additional, Slerakowska, Halina, additional, Silverman, L., additional, Glick, D., additional, Simard, A., additional, Daoust, R., additional, Smith, Edgar E., additional, Smith, R. E., additional, Fishman, William H., additional, Henzl, Milan, additional, Sobel, Harold J., additional, Avrin, Erna, additional, Sorokin, Helen P., additional, Sorokin, Sergei, additional, Sorokin, Sergei P., additional, Squier, C. A., additional, Waterhouse, J. P., additional, Steinbach, Günter, additional, Steplewski, Zenon, additional, Stitnimankarn, Tinrat, additional, Stoward, Peter J., additional, Straus, W., additional, Stumpf, Walter E., additional, Roth, Lloyd J., additional, Sylvèn, B., additional, Kanamura, Shinsuke, additional, Templeton, McCormick, additional, Tewari, H. B., additional, Tyagi, H. R., additional, Thalmann, R., additional, Glismann, L., additional, Thomas, E., additional, Tice, Lois W., additional, Tixier-Vidal, A., additional, Törö, I., additional, Bacsy, E., additional, Vadasz, Gy., additional, Rappay, Gy., additional, Tsou, K. C., additional, Chang, Mildred Y., additional, Matsukawa, S., additional, Goodwin, Cleon, additional, Lynm, Dwo, additional, Seamond, Bette, additional, Van der Ploeg, M., additional, Van Duijn, P., additional, Coulter, J. R., additional, Pascoe, E., additional, Van Fleet, D. S., additional, Van Houten, Wiecher H., additional, Vecher, A. S., additional, Masko, A. A., additional, Predkel, K. I., additional, Reshetnikov, V. N., additional, Tchaika, M. T., additional, Velican, C., additional, Velican, Doina, additional, Vendrely, C., additional, Lageron, A., additional, Tournier, P., additional, Vialli, Maffo, additional, Prenna, Giovanni, additional, Vilter, Voldemar, additional, Vittek, Josef, additional, Vogt, Arnold, additional, Vollrath, L., additional, Von Mayersbach, Heinz, additional, Andrzej, Vorbrodt, additional, Wächtler, Klaus, additional, Wakabayashi, Katsumi, additional, Bun-Ichis, Tamaoki, additional, Niel, Wald, additional, Ranshaw, Russell, additional, Weller, Roy O., additional, Welsch, Ulrich, additional, Werner, Gottfried, additional, Vick, Williams, additional, Morriss, Fran, additional, Willighagen, R. G. J., additional, Wilson, Barry W., additional, Wohlrab, Frank, additional, Wolf, Paul L., additional, Horwitz, Jerome P., additional, Freisler, Josef V., additional, Von der Muehll, Elisabeth, additional, Vazquez, Janice, additional, Wolman, Moshe, additional, Wolman, M., additional, Kalina, M., additional, Bubis, J. J., additional, Yamada, Masaoki, additional, Iwata, Sunao, additional, Yamaguchi, Hisao, additional, Yataganas, X., additional, Gahrton, G., additional, Thorell, B., additional, Young, Ian T., additional, Zaccheo, D., additional, Grossi, C. E., additional, Genta, V., additional, Riva, A., additional, Zacks, S. I., additional, Sheff, M. F., additional, Zamfirescu-Gheorghiu, M., additional, Serban, M., additional, Vladescu, C., additional, Chirulescu, Z., additional, Marcus, N., additional, Zelenin, A. V., additional, Kirianova, E. A., additional, Stepanova, N. G., additional, Zeuthen, Erik, additional, Zimmermann, Horst, additional, Zugibe, Frederick T., additional, Abrahamson, Dean E., additional, Anderson, Norman G., additional, Caspersson, Törbjorn, additional, Richard, Cornell, additional, Dougherty, William, additional, Jirasek, J. E., additional, Jonsson, Gösta, additional, Leske, Regina, additional, Moyer, Frank H., additional, Schneider, Walter C., additional, Siegel, Howard I., additional, Sternberger, Ludwig, additional, Osserman, Elliott F., additional, Weinstock, A., additional, Kåroly, Balogh, additional, and Enesco, Hildegard E., additional

Published
1968
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22. The role of different biomarkers (DNA, PCNA, apoptosis and karyotype) in prognostic evaluation of superficial transitional cell bladder carcinoma

Author

Anna Lavezzi, Biondo, B., Cazzullo, A., Giordano, F., Pallotti, F., Turconi, P., and Matturri, L.

Subjects
Aged, 80 and over, Male, Carcinoma, Transitional Cell, Chromosomes, Human, Pair 13, Apoptosis, DNA, Neoplasm, Middle Aged, Prognosis, Urinary Bladder Neoplasms, Karyotyping, Proliferating Cell Nuclear Antigen, Humans, Female, Chromosomes, Human, Pair 7, In Situ Hybridization, Fluorescence, Aged
Abstract

In order to clarify the variable behaviour of transitional cell bladder carcinomas (TCBC) with same clinico-pathologic pattern, we investigated the prognostic significance of various biomarkers (PCNA, DNA, apoptosis, karyotype).We studied 177 superficial TCBC (stage T1) undergoing transurethral resection (TUR). Analysis of biological indicators was performed on serial paraffin sections: DNA by static cytometry, karyotype by fluorescence in situ hybridisation (FISH), PCNA and apoptosis by immunohistochemistry.The most salient results are represented by prevalence of diploidy (56%), a mean PCNA labeling index (PCNA-LI) of 8.2%, nonrandom trisomies and tetrasomies of chromosome 7, and a high presence of apoptosis (in 72% of cases). These data were not related to histological grading. Multivariate analysis showed that only PCNA-LI is a an independent prognostic marker for patient survival (p = 0.01). Besides, we observed a worse prognosis in the presence of both very high PCNA indices and low or absent apoptosis.The results of this study suggest that tumor prognostic potential in TCBC should be evaluated on the basis of the association between PCNA cell kinetics and cell apoptosis information.

Published
2001

23. [Proliferative activity and chromosomal alterations of smooth muscle cells in atherosclerosis]

Author

Fernández Alonso G, Dr, Grana, Turconi P, Colombo B, Anna Lavezzi, Milei J, and Matturri L

Subjects
Chromosomes, Human, 6-12 and X, Fibroblast Growth Factors, Arteriosclerosis, Chromosomes, Human, Pair 11, Proto-Oncogene Proteins, Fibroblast Growth Factor 3, Humans, Nuclear Proteins, Muscle, Smooth, Trisomy, Tumor Suppressor Protein p53, Chromosomes, Human, Pair 7, In Situ Hybridization, Fluorescence
Abstract

Atherosclerosis is the most frequent cause of death in industrialized countries. Lesions are characterized by lipid deposits, focal thickening of the arterial wall with proliferation of smooth muscle cells (SMC), mononuclear infiltrates and neoformed vessels. In this paper, we studied the proliferative characteristics and cytogenetic alterations of SMC. These cells, expressing specific muscular actin, were diploid with an increased proliferative index for PCNA. A high percentage of SMC showed intense expression of p53. There were signs of chromosomal instability, being the most frequent findings chromosome 7 trisomy and chromosome 11 monosomy. Additionally, the gene for FGF-3 showed a marked amplification. These findings strongly suggest that SMC proliferation is active, and is related to the accumulation or mutation of the p53 oncoprotein. It also presents specific chromosomal alterations in close relation with growth factors. According to these findings SMC hyperplasia in the atherosclerosis plaque may be considered as a cellular clonal expansion.

Published
2001

24. p53 over-expression and its correlation with PCNA index in nasal polyps

Author

Anna Lavezzi, Mantovani M, Cazzullo A, Turconi P, and Matturri L

Subjects
Male, Nasal Polyps, Proliferating Cell Nuclear Antigen, Humans, Female, Middle Aged, Tumor Suppressor Protein p53, Immunohistochemistry
Abstract

Our knowledge about the etiopathogenesis of nasal polyps (Nps) is still limited. In this study, in order to define the biological features of these neoformations, we investigated with immunohistochemistry the p53 over-expression and the proliferating cell nuclear antigen (PCNA) in 32 cases of Nps and in normal mucosa of 11 control cases. The evaluation of PCNA showed a wide range of indices (0.5-18.2%) with a mean value (6.8%) significantly higher than in normal mucosa (2.9%). Over-expression of the p53 oncoprotein, observed in 50% of Nps, was statistically related to a high PCNA-index (6.8%). Our results suggest that Nps can behave, in a high percentage of cases, like tumours.

Published
2000

25. Discrete T-lymphocytic leptomeningitis of the ventral medullary surface in a case of Sudden Unexpected Infant Death

Author

Matturri L, Giulia Ottaviani, Sg, Ramos, Biondo B, and Rossi L

Abstract

The Authors report the case of a 4 month old female infant dying suddenly and unexpectedly. At post-mortem examination, nothing significant was found, except a focal T-lymphocytic brainstem leptomeningitis, involving the ventral medullary surface (VMS) particularly coincidental with the pyramids, with involvement of the outer layer of the nucleus arcuatus (NARC). Moreover, the NARC itself presented, on serial sections, interdigitated subdivisions. To the present authors' best knowledge, no case has been recordered in the literature, as yet, exhibiting VMS inflammation, evidently acquired (likely viral) in nature, associated to a NARC developmental defect, altogether bespeaking for the etio-pathogenic importance of such a combined pathology of the central chemosensitive field among the long debated mechanisms of SIDS.

Published
1999

26. [Sudden infant death syndrome (SIDS): a case with accessory pathways and resorptive degeneration]

Author

Guareschi M, Giulia Ottaviani, Sg, Ramos, and Matturri L

Subjects
Heart Conduction System, Infant, Newborn, Humans, Arrhythmias, Cardiac, Female, Sudden Infant Death
Abstract

We report the case of a 71 day-old female infant victim of SIDS. Histological observations were focused on the cardiac conduction system. We observed accessory pathways of Mahaim type with areas of resorptive degeneration. These findings, associated with particular conditions and/or neurovegetative stimuli, could cause potentially malignant arrhythmias.

Published
1998

27. [Dispersion of junctional tissue and its consequences in a case of sudden infant death]

Author

Giulia Ottaviani, Goisis M, Sg, Ramos, and Matturri L

Subjects
Male, Bundle of His, Heart Conduction System, Atrioventricular Node, Infant, Newborn, Humans, Sudden Infant Death
Abstract

This article reports a case of sudden infant death syndrome in a 1-month-old male. Some important abnormalities of the cardiac conduction system were found, consisting of persistent fetal dispersion of the atrioventricular node and His bundle, accessory atrioventricular pathways of Mahaim type and resorptive degeneration. These changes could be considered as a morphological substrate for cardiac arrhythmias.

Published
1998

28. Prognostic significance of different biological markers (DNA index, PCNA index, apoptosis, p53, karyotype) in 126 adenocarcinoma gastric biopsies

Author

Matturri L, Biondo B, Cazzullo A, Colombo B, Giordano F, Guarino M, Pallotti F, Turconi P, and Anna Lavezzi

Subjects
Aged, 80 and over, Male, Apoptosis, Adenocarcinoma, Middle Aged, Prognosis, Diploidy, Immunoenzyme Techniques, Stomach Neoplasms, Karyotyping, Proliferating Cell Nuclear Antigen, Biomarkers, Tumor, Humans, Female, Tumor Suppressor Protein p53, Chromosomes, Human, Pair 7, In Situ Hybridization, Fluorescence, Aged, Follow-Up Studies
Abstract

The different clinical evolution of gastric adenocarcinomas with the same clinico-pathologic characteristics prompted the authors to investigate the prognostic significance of different biological markers.One hundred twenty-six preoperative cancer gastric biopsies, selected according the stage evaluated after following gastrectomy, were examined for DNA content by means the static cytometry, proliferating cell nuclear antigen (PCNA), p53 mutation, apoptosis by immunohistochemistry and karyotype using fluorescence in situ hybridization (FISH) techniques.The gastric cancers, ail belonging at stage III, were adenocarcinomas histologically typed as: 26 well differentiated (G1), 45 moderately differentiated (G2), 43 poorly differentiated (G3) and 12 of undifferentiated type with signet-ring cells. The tumours showed a prevalence of diploidy (68%), a mean PCNA-LI of 4.8%, trisomy of chromosome 7 in 40% of the cases, low presence of apoptosis (30%) and p53 mutation (17%). Only apoptosis was significantly correlated to histological diagnosis (p = 0.009). A multivariate analysis showed that the DNA content and PCNA-LI were the only independent prognostic markers for survival (p = 0.005 and p = 0.0002 respectively).The evaluation of these two biological variables, especially of the PCNA index, on gastric cancer biopsies may be useful in predicting the aggressiveness of each tumor and in identifying patients in need of additional perioperative therapies.

Published
1998

29. Thymidine labeling index in colorectal carcinoma: relation to clinicopathological parameters and to mitotic index

Author

Matturri, L., Biondo, B., and Anna Lavezzi

Subjects
Adult, Aged, 80 and over, Male, Mitotic Index, Humans, Female, Middle Aged, Colorectal Neoplasms, Cell Division, Aged, Thymidine
Abstract

Two cell-kinetic parameters, the thymidine labeling index (T-LI) and the mitotic index (MI) were determined for a prospective series of 74 primary colorectal cancers. Dukes' stages were used to define the extent of the tumor: 10 tumors were classified as Dukes' A, 36 as Dukes' B, and 22 as Dukes' C. Of these tumors, 14 were well-differentiated, 44 moderately differentiated, and 15 poorly differentiated adenocarcinomas. The H3dT-LI values obtained varied widely, from 2.5 to 38.9% (median value: 16.8%). The MI shows a range of from 0 to 13.2% with a median value of 3.2%. The T-LI values were independent of the sex and age of the patients and of the histological grading and Dukes' stage. Conversely, the MI was related to histological grading. This study indicates that the T-LI, whose application has reached the gold standard, still represents an independent parameter and the most sensible, objective, and specific complementary method for the analysis of the S phase.

Published
1997

30. Morphometric and densitometric approach in hypertrophic cardiomyopathy (HCM)

Author

Matturri, L., Biondo, B., Grosso, E., Anna Lavezzi, and Rossi, L.

Subjects
Adult, Cell Nucleus, Male, Heart Ventricles, Myocardium, Cell Count, DNA, Cardiomyopathy, Hypertrophic, Middle Aged, Fibrosis, Heart Septum, Image Processing, Computer-Assisted, Humans, Female, Heart Atria, Aged, Densitometry
Abstract

The aim of this study was to apply an easy method for the quantitative evaluation of changes in myocardial fibrocell size (area, diameter, circular shape factor, nuclear area, DNA content), and in the fibrous-interstitial area in hypertrophic cardiomyopathy (HCM) by mean of a computerized image analysis. A Vidas image analyser was employed for the morphometric study. The following parameters were assessed: area, maximum and minimum diameters, circular shape factor of myocytes; percentage of fibrosis; DNA content (integrated optical density) nuclear area of myocytes. The morphometric results in HCM compared to the ones in normal hearts, indicate an increase in the myocyte area and the transverse diameters, especially in the septum and left ventricle, altogether illustrating the hypertrophic condition of the myocytes, and increased fibrotic area was found in the left ventricular wall and septum (22.6 +/- 2.1% and 15.9 +/- 2.9% respectively). Densitometric analysis showed a significant increase in all test samples then compared with controls. The increase in the two nuclear parameters (area and DNA) also suggests hyperplasia. It is concluded that the morphometric determination of the morphologic abnormalities occurring in HCM by a rapid and less laborious approach, is an extremely useful method to describe the characteristics of this pathologic condition.

Published
1995

33. [Prognostic implications of the proliferation index (H3-TdR-labeling index) and ploidy in neuroectodermal tumors (astrocytomas and glioblastomas)]

Author

Anna Lavezzi, Biondo B, Ml, Repetti, Varesi C, Masini B, and Matturri L

Subjects
Adult, Male, Ploidies, Time Factors, Adolescent, DNA, Neoplasm, Glioma, Astrocytoma, Middle Aged, Aneuploidy, Prognosis, Diploidy, Child, Preschool, Karyotyping, Mitotic Index, Autoradiography, Humans, Female, Child, Glioblastoma, Aged, Densitometry
Abstract

Kinetic cellular methods were used in 53 cases of various sizes of astrocytomas and glioblastomas to obtain reliable prognostic information. Kinetic analysis revealed a wide variation of proliferative activity, with a gradual increase of the mean value from the most differentiated astrocytomas to glioblastomas. DNA content was significantly correlated with the degree of histological differentiation. Chromosomic patterns, which were detected in a few cases, were generally aspecific. The sole recurrent alteration in the karyotype was a small metacentric marker. The comparison of results obtained with the follow-up of patients showed that the labeling index offers a more accurate estimate of the proliferative potential of individual tumours, and thus of the probability of survival, than histological diagnosis and the evaluation of other biological parameters such as ploidy and karyotype.

Published
1992

34. [Clinical significance of nuclear DNA content in human gastric tumors. A static cytometry study in 87 cases]

Author

Matturri L, Biondo B, and Anna Lavezzi

Subjects
Adult, Male, Stomach Neoplasms, Lymphatic Metastasis, Humans, Female, Cytophotometry, DNA, Neoplasm, Adenocarcinoma, Middle Aged, Aneuploidy, Diploidy, Aged
Abstract

In recent years the abnormal DNA content of cancer cells and the ploidy model have played an important role in biological and medical research aimed at achieving a more accurate diagnostic and prognostic assessment. Static cytometry was studied in histological sections using an image analyser which enabled the DNA content of cancer cells coloured using Feulgen's method, the elective method for nucleic acids, to be evaluated. A high percentage of aneuploidy in human gastric tumours was found to be correlated with a low degree of histological differentiation (G3), with tumoral invasion of the lowest tissue strata and neighbouring lymph nodes, and with a negative prognosis. The practical clinical application of DNA evaluation therefore allows cases which evolve more rapidly since they possess a greater tumoral aggressiveness to be identified (aneuploid tumours).

Published
1991

35. [Sudden infant death (SIDS): a case with multiple accessory atrioventricular pathways]

Author

Matturri L, Melluso A, Nappo A, Quattrone P, Varesi C, and Rossi L

Subjects
Male, Atrioventricular Node, Humans, Infant, Sudden Infant Death
Abstract

A 4-month-old infant dying suddenly is diagnosed as sudden infant death syndrome (SIDS). Important modifications of the cardiac conduction system were found, consisting of conspicuous accessory atrioventricular (AV) pathways of Mahaim and Kent type, which can be regarded as arrhythmogenic in nature.

Published
1991

36. Cardiac toxoplasmosis in pathology of acquired immunodeficiency syndrome

Author

Matturri L, Quattrone P, Varesi C, and Rossi L

Subjects
Adult, Male, Acquired Immunodeficiency Syndrome, Myocarditis, Humans, Female, Autopsy, Toxoplasmosis
Abstract

Four cases of myocarditis from toxoplasma gondii were observed at autopsy among 18 consecutive cases of acquired immunodeficiency syndrome (AIDS). All cases showed spotty inflammatory myocardial infiltration, consisting mainly of T lymphocytes and, to a lesser extent, of B lymphocytes, histiocytes, mastocytes and eosinophilic granulocytes, with presence of toxoplasma gondii in the cytoplasm of a few myocardial cells. The incidence of toxoplasmic myocarditis in heart involvement in AIDS was 22% in our cases, manifold higher than in preceding reports from the literature. This suggests that cardiac toxoplasmosis is far from rare in patients with AIDS.

Published
1990

39. Arrhythmogenic Right Ventricular Cardiomyopathy in a Child with Dandy-Walker Syndrome: Sudden Cardiac Death Misdiagnosed as Sudden Infant Death Syndrome (SIDS).

Author

Mecchia, D., Lavezzi, A. M., Rossi, G., and Matturri, L.

Subjects
CARDIOMYOPATHIES, DANDY-Walker syndrome, SUDDEN infant death syndrome, HEART diseases, MYOCARDIUM, CARDIAC arrest, JUVENILE diseases
Abstract

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a heart muscle disease characterised by arrhythmias of right ventricular origin, due to transmural fatty or fibrofatty replacement of atrophic myocardium. In general, the pathology is seldom diagnosed below the age of 10 years old. We report a case of a 5-year-old female child with Dandy-Walker Syndrome, who died suddenly the night after surgical replacement of the ventriculo-peritoneal shunting catheter. She never had any heart problems and the ECGs have never shown significant alterations. Histological examination of the common myocardium showed focal fatty replacement of the right ventricle, mostly evident in the subepicardial and mid-third of the free wall and of the interventricular septum. Finally, the histological examination of the atrio-ventricular node showed some anomalies of the conduction system. Probably the association of both abnormalities have caused a fatal arrhythmia, occurred after the surgical replacement of the ventriculo-peritoneal shunting catheter. [ABSTRACT FROM AUTHOR]

Published
2014
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