Search

The action of transforming medical education recommends active teaching-learning methodologies with student participation in the construction of knowledge. This process of change is based on national curriculum guidelines, as well as on the concept of health as a social phenomenon and on the consolidation of a single, quality health system. Objective: To report the experience of medicine professors at a university in the city of Rio de Janeiro. Method: This study is an experience report of first-term academics of the Discipline IESC1 of the Medicine Course at UNIGRANRIO\AFYA. Results: The participation of medical students in the work process of the Family Health Teams (ESF), without distinction of functions or positions, in order to know the whole process and obtain significant learning focused on the reality experienced by USF professionals, ends up transforming this participation into a need to learn for them. Conclusion: The knowledge provided by the IESC discipline allows the student to develop skills to act in Primary Care in a critical and reflective way, in view of the possibility of confronting theory and practice. La acción de transformar la educación médica recomienda metodologías activas de enseñanza-aprendizaje con participación de los estudiantes en la construcción del conocimiento. Este proceso de cambio se sustenta en los lineamientos curriculares nacionales, así como en la concepción de la salud como fenómeno social y en la consolidación de un sistema de salud único y de calidad. Objetivo: Relatar la experiencia de profesores de medicina de una universidad de la ciudad de Rio de Janeiro. Método: Este estudio es un relato de experiencia de académicos de primer término de la Carrera de Medicina IESC1 de la UNIGRANRIO\AFYA. Resultados: La participación de los estudiantes de medicina en el proceso de trabajo de los Equipos de Salud de la Familia (ESF), sin distinción de funciones o cargos, con el fin de conocer todo el proceso y obtener aprendizajes significativos centrados en la realidad vivida por los profesionales de las USF, acaba transformando esta participación en una necesidad de aprender por ellos. Conclusión: Los conocimientos proporcionados por la disciplina IESC permiten al estudiante desarrollar habilidades para actuar en la Atención Primaria de manera crítica y reflexiva, ante la posibilidad de confrontar la teoría y la práctica. A ação de transformação da educação médica recomenda metodologias ativas de ensino aprendizagem com a participação do estudante na construção do conhecimento. Esse processo de mudança se sustenta nas diretrizes curriculares nacionais, bem como na concepção de saúde como fenômeno social e na consolidação de um sistema de saúde único e de qualidade. Objetivo: Relatar a experiência vivenciada pelos docentes de medicina de uma universidade da cidade do Rio de Janeiro. Método: Este estudo trata-se de um relato de experiência dos acadêmicos de primeiro período da Disciplina IESC1 do Curso de medicina da UNIGRANRIO\AFYA. Resultados:A participação dos acadêmicos de medicina no processo de trabalho das Equipes de Saúde da Família (ESF), sem distinção de funções ou cargos, a fim de conhecer todo o processo e obterem aprendizagem significativa com foco na realidade vivenciadas pelos profissionais da USF, acaba transformando essa participação em uma necessidade de aprender para eles. Conclusão: O conhecimento proporcionado pela disciplina IESC, permite que o aluno desenvolva habilidades para atuar na Atenção Básica de forma crítica e reflexiva, tendo em vista a possibilidade de confrontar teoria e prática.

Although of several studies that associate chronic hyperglycemia with tendinopathy, the connection between morphometric changes as witnessed by magnetic resonance (MR) images, nanostructural changes, and inflammatory markers have not yet been fully established. Therefore, the present study has as a hypothesis that the Achilles tendons of rats with diabetes mellitus (DM) exhibit structural changes. The animals were randomly divided into two experimental groups: Control Group (n = 06) injected with a vehicle (sodium citrate buffer solution) and Diabetic Group (n = 06) consisting of rats submitted to intraperitoneal administration of streptozotocin. MR was performed 24 days after the induction of diabetes and images were used for morphometry using ImageJ software. Morphology of the collagen fibers within tendons was examined using Atomic Force microscopy (AFM). An increase in the dimension of the coronal plane area was observed in the diabetic group (8.583 ± 0.646 mm2/100g) when compared to the control group (4.823 ± 0.267 mm2/100g) resulting in a significant difference (p = 0.003) upon evaluating the Achilles tendons. Similarly, our analysis found an increase in the size of the transverse section area in the diabetic group (1.328 ± 0.103 mm2/100g) in comparison to the control group (0.940 ± 0.01 mm2/100g) p = 0.021. The tendons of the diabetic group showed great irregularity in fiber bundles, including modified grain direction and jagged junctions and deformities in the form of collagen fibrils bulges. Despite the morphological changes observed in the Achilles tendon of diabetic animals, IL1 and TNF-α did not change. Our results suggest that DM promotes changes to the Achilles tendon with important structural modifications as seen by MR and AFM, excluding major inflammatory changes.

Endometriosis involves the growth of endometriotic tissue outside the uterine cavity, and is frequently associated with different malignancies. A well-reported alteration in the disease microenvironment is the proliferation of new blood vessels around the lesions, as part of a necessary repertory to contribute to the invasiveness and development of infiltrating endometriosis. Therefore, the establishment of a reliable experimental model is essential to elucidate the contribution of angiogenesis and to develop new therapeutic approaches to endometriosis treatment. For this purpose we transplanted endometrial fragments from green fluorescent protein (GFP)-mice (n=20) into the peritoneal cavity of wild-type mice (n=20), and then analyzed the morphological changes and the process of angiogenesis. The lesions were cystic and vascularized, and showed morphological hallmarks such as endometrial glands and stroma. An increase in endometriotic lesion vascular density was revealed by immunostaining and RNAm expression for Vegf and its receptor Flk-1, and the lesions were confirmed as a tissue-donor source by GFP fluorescent cells. The same pattern was observed through staining of activated macrophages and an increase of about 25% in the number of macrophage-positive cells was also demonstrated in endometriotic lesions by flow cytometry, which concords with previous data that correlate endometriosis, angiogenesis and inflammation. According to our understanding, this is the first demonstration that the pattern of the angiogenic process in the GFP endometriosis model is very similar to that of cancer. These observations will be useful for investigation of the process of angiogenesis involved in the attachment and invasion of endometrial cells, as well as an in vivo platform model to study the effects of antiangiogenic drugs.