7,558 results on '"Mattis, A"'
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2. The Internet of Forgotten Things: European Cybersecurity Regulation and IoT Manufacturer Cessation
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Schip, Mattis van 't
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Computer Science - Computers and Society - Abstract
Many modern consumer devices rely on network connections and cloud services to perform their core functions. This dependency is especially present in Internet of Things (IoT) devices, which combine hardware and software with network connections (e.g., a 'smart' doorbell with a camera). This paper argues that current European product legislation, which aims to protect consumers of, inter alia, IoT devices, has a blind spot for an increasing problem in the competitive IoT market: manufacturer cessation. Without the manufacturer's cloud servers, many IoT devices cannot perform core functions such as data analysis. If an IoT manufacturer ceases their operations, consumers of the manufacturer's devices are thus often left with a dysfunctional device and, as the paper shows, hardly any legal remedies. This paper therefore investigates three properties that could support legislators in finding a solution for IoT manufacturer cessation: i) pre-emptive measures, aimed at ii) manufacturer-independent iii) collective control. The paper finally shows how these three properties already align with current legislative processes surrounding 'interoperability' and open-source software development.
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- 2024
3. The derived $\infty$-category of Cartier Modules
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Mattis, Klaus and Weiß, Timo
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Mathematics - Algebraic Geometry ,Mathematics - Commutative Algebra - Abstract
For an endofunctor $F\colon\mathcal{C}\to\mathcal{C}$ on an ($\infty$-)category $\mathcal{C}$ we define the $\infty$-category $\operatorname{Cart}(\mathcal{C},F)$ of generalized Cartier modules as the lax equalizer of $F$ and the identity. This generalizes the notion of Cartier modules on $\mathbb{F}_p$-schemes considered in the literature. We show that in favorable cases $\operatorname{Cart}(\mathcal{C},F)$ is monadic over $\mathcal{C}$. If $\mathcal{A}$ is a Grothendieck abelian category and $F\colon\mathcal{A}\to\mathcal{A}$ is an exact and colimit-preserving endofunctor, we use this fact to construct an equivalence $\mathcal{D}(\operatorname{Cart}(\mathcal{A},F)) \simeq \operatorname{Cart}(\mathcal{D}(\mathcal{A}),\mathcal{D}(F))$ of stable $\infty$-categories. We use this equivalence to give a more conceptual construction of the perverse t-structure on $\mathcal{D}^b_{\operatorname{coh}}(\operatorname{Cart}(\operatorname{QCoh}(X), F_*))$ for any Noetherian $\mathbb{F}_p$-scheme $X$ with finite absolute Frobenius $F\colon X\to X$., Comment: 35 pages, comments welcome!
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- 2024
4. Towards Privacy-Preserving Relational Data Synthesis via Probabilistic Relational Models
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Luttermann, Malte, Möller, Ralf, and Hartwig, Mattis
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Computer Science - Artificial Intelligence ,Computer Science - Databases ,Computer Science - Machine Learning - Abstract
Probabilistic relational models provide a well-established formalism to combine first-order logic and probabilistic models, thereby allowing to represent relationships between objects in a relational domain. At the same time, the field of artificial intelligence requires increasingly large amounts of relational training data for various machine learning tasks. Collecting real-world data, however, is often challenging due to privacy concerns, data protection regulations, high costs, and so on. To mitigate these challenges, the generation of synthetic data is a promising approach. In this paper, we solve the problem of generating synthetic relational data via probabilistic relational models. In particular, we propose a fully-fledged pipeline to go from relational database to probabilistic relational model, which can then be used to sample new synthetic relational data points from its underlying probability distribution. As part of our proposed pipeline, we introduce a learning algorithm to construct a probabilistic relational model from a given relational database., Comment: Accepted to the Proceedings of the 47th German Conference on Artificial Intelligence (KI 2024)
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- 2024
5. Solving the Synthetic Riddle of Colloidal 2D PbTe Nanoplatelets with Tunable Near-Infrared Emission
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Biesterfeld, Leon, Vochezer, Mattis T., Kögel, Marco, Zaluzhnyy, Ivan A., Rosebrock, Marina, Klepzig, Lars F., Leis, Wolfgang, Seitz, Michael, Meyer, Jannik C., and Lauth, Jannika
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Near-infrared emitting colloidal two-dimensional (2D) PbX (X=S, Se) nanoplatelets have emerged as interesting materials with strong size quantisation in the thickness dimension. They act as model systems for efficient charge carrier multiplication and hold potential as intriguing candidates for finer-based photonic quantum applications. However, synthetic access to the third family member, 2D PbTe, remains elusive due to a challenging precursor chemistry. Here, we report a direct synthesis for 2D PbTe nanoplatelets (NPLs) with unable photoluminescence (PL, 910-1460 nm (1.36-0.85 eV), PLQY 1-15 %), based on aminophosphine precursor chemistry. Ex-situ transamination of tris(dimethylamino)phosphine telluride with octylamine is confirmed by 31P NMR and yields a reactive tellurium precursor for the formation of 2D PbTe NPLs at temperatures as low as 0 {\deg}C. The PL position of the PbTe NPLs is unable by controlling the Pb:Te ration in the reaction. GIWAXS confirms the 2D geometry of the NPLs and the formation of superlattices. The importance of a post-synthetic passivation of the PbTe NPLs by PbI2 to ensure colloidal stability of the otherwise oxygen sensitive samples is supported by X-ray photoelectron spectroscopy. Our results expand and complete the row of lead chalcogenide-based 2D NPLs, opening up new ways for further pushing the optical properties of 2D NPLs into the infrared and toward technologically relevant wavelengths.
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- 2024
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6. Generating Feature Vectors from Phonetic Transcriptions in Cross-Linguistic Data Formats
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Rubehn, Arne, Nieder, Jessica, Forkel, Robert, and List, Johann-Mattis
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Computer Science - Computation and Language - Abstract
When comparing speech sounds across languages, scholars often make use of feature representations of individual sounds in order to determine fine-grained sound similarities. Although binary feature systems for large numbers of speech sounds have been proposed, large-scale computational applications often face the challenges that the proposed feature systems -- even if they list features for several thousand sounds -- only cover a smaller part of the numerous speech sounds reflected in actual cross-linguistic data. In order to address the problem of missing data for attested speech sounds, we propose a new approach that can create binary feature vectors dynamically for all sounds that can be represented in the the standardized version of the International Phonetic Alphabet proposed by the Cross-Linguistic Transcription Systems (CLTS) reference catalog. Since CLTS is actively used in large data collections, covering more than 2,000 distinct language varieties, our procedure for the generation of binary feature vectors provides immediate access to a very large collection of multilingual wordlists. Testing our feature system in different ways on different datasets proves that the system is not only useful to provide a straightforward means to compare the similarity of speech sounds, but also illustrates its potential to be used in future cross-linguistic machine learning applications., Comment: To appear in the Proceedings of the 2024 Meeting of the Society for Computation in Linguistics (SCiL)
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- 2024
7. Unstable arithmetic fracture squares in $\infty$-topoi
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Mattis, Klaus
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Mathematics - Algebraic Topology - Abstract
We show that for a large class of $\infty$-topoi there exist unstable arithmetic fracture squares, i.e. squares which recover a nilpotent sheaf $F$ as the pullback of the rationalization of $F$ with the product of the $p$-completions of $F$ ranging over all primes $p\in\mathbb Z$., Comment: 34 pages. Comments welcome!
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- 2024
8. The pro-Nisnevich topology
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Mattis, Klaus
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Mathematics - Algebraic Geometry - Abstract
We construct the pro-Nisnevich topology, an analog of the pro-\'etale topology. We then show that the Nisnevich $\infty$-topos embeds into the pro-Nisnevich $\infty$-topos, and that the pro-Nisnevich $\infty$-topos is locally of homotopy dimension $0$., Comment: 10 pages, Comments welcome!
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- 2024
9. Quantifying seasonal hydrogen storage demands under cost and market uptake uncertainties in energy system transformation pathways
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Frischmuth, Felix, Berghoff, Mattis, Braun, Martin, and Haertel, Philipp
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Economics - General Economics - Abstract
Climate neutrality paradigms put electricity systems at the core of a clean energy supply. At the same time, indirect electrification, with a potential uptake of hydrogen or derived fuel economy, plays a crucial role in decarbonising the energy supply and industrial processes. Besides energy markets coordinating the transition, climate and energy policy targets require fundamental changes and expansions in the energy transmission, import, distribution, and storage infrastructures. While existing studies identify relevant demands for hydrogen, critical decisions involve imports versus domestic fuel production and investments in new or repurposing existing pipeline and storage infrastructure. Linking the pan-European energy system planning model SCOPE SD with the multiperiod European gas market model IMAGINE, the case study analysis and its transformation pathway results indicate extensive network development of hydrogen infrastructure, including expansion beyond refurbished methane infrastructure. However, the ranges of future hydrogen storage costs and market uptake restrictions expose and quantify the uncertainty of its role in Europes transformation. The study finds that rapidly planning the construction of hydrogen storage and pipeline infrastructure is crucial to achieving the required capacity by 2050.
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- 2024
10. Lifted Causal Inference in Relational Domains
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Luttermann, Malte, Hartwig, Mattis, Braun, Tanya, Möller, Ralf, and Gehrke, Marcel
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Computer Science - Artificial Intelligence ,Computer Science - Data Structures and Algorithms - Abstract
Lifted inference exploits symmetries in probabilistic graphical models by using a representative for indistinguishable objects, thereby speeding up query answering while maintaining exact answers. Even though lifting is a well-established technique for the task of probabilistic inference in relational domains, it has not yet been applied to the task of causal inference. In this paper, we show how lifting can be applied to efficiently compute causal effects in relational domains. More specifically, we introduce parametric causal factor graphs as an extension of parametric factor graphs incorporating causal knowledge and give a formal semantics of interventions therein. We further present the lifted causal inference algorithm to compute causal effects on a lifted level, thereby drastically speeding up causal inference compared to propositional inference, e.g., in causal Bayesian networks. In our empirical evaluation, we demonstrate the effectiveness of our approach., Comment: Accepted to the Proceedings of the 3rd Conference on Causal Learning and Reasoning (CLeaR-24)
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- 2024
11. An Overview of Major Occupational Lung Diseases
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Ufelle, Alexander C., Bernardo, Angela Mattis, and Williams, Adelle
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Lung diseases -- Care and treatment -- Risk factors -- Prevention ,Occupational diseases -- Risk factors -- Prevention -- Care and treatment - Abstract
Occupational lung diseases result from worker exposure in occupational settings to unhealthy environments and agents, such as silica dust, antigens, coal dust, washed coal/mixed dust, asbestos, and beryllium. Most of these conditions have long latency periods, with disease manifesting years after exposure. Approximately 1 million workers in the U.S. report occupational exposure-related illnesses, including respiratory diseases. We evaluated major occupational lung diseases via an extensive literature review and present here advances in diagnosing major occupational lung diseases, preventive strategies, and regulatory considerations for maintaining a healthy workforce. We include the widely studied occupational lung diseases asbestosis, coal workers' pneumoconiosis and all other pneumoconioses, silicosis, byssinosis, malignant mesothelioma, hypersensitivity pneumonitis, and work-related asthma. The chemistry and physical properties of exposed materials play a role in the severity and pathogenesis of most occupational lung diseases. Knowledge of clinical signs and symptoms of these diseases, exposure history, and consensus diagnostic tools and criteria are crucial for accurate diagnosis, early detection, management, and improved outcomes. Further, regulatory agencies and other interested parties need to develop new and improved surveillance strategies, exposure limits, and technological and industrial safety measures, as well as implement regulations to guide industries and provide recommendations to protect all workers and reduce disease burden. Keywords: diagnosis, disease burden, occupational lung diseases, prevention, regulations, latency period, Introduction Widely studied occupational lung diseases include asbestosis, coal workers' pneumoconiosis (CWP) and all pneumoconioses, silicosis, byssinosis, malignant mesothelioma, hypersensitivity pneumonitis, asthma, chronic obstructive pulmonary disease (COPD), and lung cancer [...]
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- 2024
12. The Impact of Aging on Occupational Lung Disease
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Ufelle, Alexander C., Williams, Adelle, and Bernardo, Angela Mattis
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Lung diseases -- Demographic aspects -- Prognosis -- Risk factors ,Occupational diseases -- Demographic aspects -- Prognosis -- Risk factors ,Aged -- Employment - Abstract
The majority of occupational lung diseases have long latency periods, with disease manifesting at an older age. We conducted an extensive literature review and analyzed data for age-related mortality, the impact of age on the lungs and occupational lung diseases, changes in the workforce, and considerations for surveillance to maintain a healthy workforce. Age is a major factor in occupational lung diseases, which in turn predisposes older adults to other health conditions and reduces their quality of life and life expectancy. More specifically, age-related changes in the lungs increase the susceptibility to environmental exposure-induced lung injuries and are linked to poor prognosis. Data from the Work-Related Lung Disease Surveillance Report published by the National Institute for Occupational Safety and Health (NIOSH, 2008) indicated that death from occupational lung diseases among U.S. residents peaked in the age group 75-84 years. Interestingly, the age group 65-74 years recorded a substantial number of deaths, second to the age group 75-84 years. This trend represents a shift in U.S. mortality for all diseases, which peaks at >85 years. Improved surveillance and early detection will be instrumental in reducing the burden of occupational lung injury in older adults, many of whom are staying in the workforce longer. Keywords: aging, latency period, mortality, occupational lung disease, surveillance, Introduction Advanced age is the major risk factor for death for all age-related adult chronic diseases (Schneider et al., 2021) and for developing chronic lung conditions such as chronic obstructive [...]
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- 2024
13. A Computational Model for the Assessment of Mutual Intelligibility Among Closely Related Languages
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Nieder, Jessica and List, Johann-Mattis
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Computer Science - Computation and Language - Abstract
Closely related languages show linguistic similarities that allow speakers of one language to understand speakers of another language without having actively learned it. Mutual intelligibility varies in degree and is typically tested in psycholinguistic experiments. To study mutual intelligibility computationally, we propose a computer-assisted method using the Linear Discriminative Learner, a computational model developed to approximate the cognitive processes by which humans learn languages, which we expand with multilingual semantic vectors and multilingual sound classes. We test the model on cognate data from German, Dutch, and English, three closely related Germanic languages. We find that our model's comprehension accuracy depends on 1) the automatic trimming of inflections and 2) the language pair for which comprehension is tested. Our multilingual modelling approach does not only offer new methodological findings for automatic testing of mutual intelligibility across languages but also extends the use of Linear Discriminative Learning to multilingual settings., Comment: To appear in: Proceedings of the 6th Workshop on Research in Computational Linguistic Typology and Multilingual NLP (SIGTYP 2024)
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- 2024
14. Are Sounds Sound for Phylogenetic Reconstruction?
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Häuser, Luise, Jäger, Gerhard, Rama, Taraka, List, Johann-Mattis, and Stamatakis, Alexandros
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Computer Science - Computation and Language ,Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
In traditional studies on language evolution, scholars often emphasize the importance of sound laws and sound correspondences for phylogenetic inference of language family trees. However, to date, computational approaches have typically not taken this potential into account. Most computational studies still rely on lexical cognates as major data source for phylogenetic reconstruction in linguistics, although there do exist a few studies in which authors praise the benefits of comparing words at the level of sound sequences. Building on (a) ten diverse datasets from different language families, and (b) state-of-the-art methods for automated cognate and sound correspondence detection, we test, for the first time, the performance of sound-based versus cognate-based approaches to phylogenetic reconstruction. Our results show that phylogenies reconstructed from lexical cognates are topologically closer, by approximately one third with respect to the generalized quartet distance on average, to the gold standard phylogenies than phylogenies reconstructed from sound correspondences., Comment: Paper accepted for SIGTYP (2024): H\"auser, Luise; J\"ager, Gerhard; List, Johann-Mattis; Rama, Taraka; and Stamatakis, Alexandros (2024): Are sounds sound for phylogenetic reconstruction? In: Proceedings of the 6th Workshop on Research in Computational Linguistic Typology and Multilingual NLP (SIGTYP 2024)
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- 2024
15. Unstable $p$-completion in motivic homotopy theory
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Mattis, Klaus
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Mathematics - Algebraic Geometry ,Mathematics - Algebraic Topology - Abstract
We define unstable $p$-completion in general $\infty$-topoi and the unstable motivic homotopy category, and prove that the $p$-completion of a nilpotent sheaf or motivic space can be computed on its Postnikov tower. We then show that the ($p$-completed) homotopy groups of the $p$-completion of a nilpotent motivic space $X$ fit into short exact sequences $0 \to \mathbb L_0 \pi_n(X) \to \pi_n^p(X_p^\wedge) \to \mathbb L_1 \pi_{n-1}(X) \to 0$, where the $\mathbb L_i$ are (versions of) the derived $p$-completion functors, analogous to the classical situation., Comment: 98 pages. Comments welcome!
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- 2024
16. Verflixte Nägel
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Eicher, Laurie, Bertlich, Mattis, French, Lars E., Flaig, Michael, and Oppel, Eva
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- 2024
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17. Seltene Allergie auf Sperma
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Glatzel, Valerie, Bertlich, Mattis, and Oppel, Eva Maria
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- 2024
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18. Diagnostics of allergic rhinitis under dupilumab therapy
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Huber, Patrick, Gröger, Moritz, Stihl, Clemens, Frankenberger, Hanna, Bertlich, Mattis, Haubner, Frank, and Gellrich, Donata
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- 2024
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19. Subjective Discomfort during Botulinumtoxin Injections Dependent on Injection Site and Needle Size: A Comparison Between 30G, 33G and 34G Needles
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Kämmerer, Till A., Bertlich, Randolf, Hartmann, Daniela, Jakob, Mark, Weiss, Bernhard G., Bertlich, Ines, Ihler, Friedrich, Wiggenhauser, Paul Severin, and Bertlich, Mattis
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- 2024
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20. Racial and Ethnic Differences in Distress, Depression, and Quality of Life in people with hemophilia
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Fedewa, Stacey A., Buckner, Tyler W., Parks, Sara Guasch, Tran, Duc Q., Cafuir, Lorraine, Antun, Ana G., Mattis, Shanna, and Kempton, Christine L.
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- 2024
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21. Representing and Computing Uncertainty in Phonological Reconstruction
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List, Johann-Mattis, Hill, Nathan W., Forkel, Robert, and Blum, Frederic
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Computer Science - Computation and Language - Abstract
Despite the inherently fuzzy nature of reconstructions in historical linguistics, most scholars do not represent their uncertainty when proposing proto-forms. With the increasing success of recently proposed approaches to automating certain aspects of the traditional comparative method, the formal representation of proto-forms has also improved. This formalization makes it possible to address both the representation and the computation of uncertainty. Building on recent advances in supervised phonological reconstruction, during which an algorithm learns how to reconstruct words in a given proto-language relying on previously annotated data, and inspired by improved methods for automated word prediction from cognate sets, we present a new framework that allows for the representation of uncertainty in linguistic reconstruction and also includes a workflow for the computation of fuzzy reconstructions from linguistic data., Comment: To appear in: Proceedings of the 4th Workshop on Computational Approaches to Historical Language Change
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- 2023
22. Fluoride-related changes in the fetal cord blood proteome; a pilot study
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Tuomivaara, Sami T, Fisher, Susan J, Hall, Steven C, Goin, Dana E, Mattis, Aras N, and Den Besten, Pamela K
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Epidemiology ,Public Health ,Health Sciences ,Women's Health ,Pediatric ,Pregnancy ,Reproductive health and childbirth ,Humans ,Fetal Blood ,Female ,Pilot Projects ,Fluorides ,Proteome ,California ,Adult ,Pregnancy Trimester ,Second ,Maternal Exposure ,Young Adult ,Environmental Pollutants ,Public Health and Health Services ,Toxicology ,Public health - Abstract
BackgroundFluoride exposure during pregnancy has been associated with various effects on offspring, including changes in behavior and IQ. To provide clues to possible mechanisms by which fluoride may affect human fetal development, we completed proteomic analyses of cord blood serum collected from second-trimester pregnant women residing in northern California, USA.ObjectiveTo identify changes in cord blood proteins associated with maternal serum fluoride concentration in pregnant women.MethodsThe proteomes of 19 archived second-trimester cord blood samples from women living in northern California, USA, and having varied serum fluoride concentrations, were analyzed by quantitative mass spectrometry. The 327 proteins that were quantified were characterized by their abundance relative to maternal serum fluoride concentration, and subjected to pathway analyses using PANTHER and Ingenuity Pathway Analysis processes.ResultsPathway analyses showed significant increases in process related to reactive oxygen species and cellular oxidant detoxification, associated with increasing maternal serum fluoride concentrations. Pathways showing significant decreases included complement cascade, suggesting alterations in alterations in process associated with inflammation.ConclusionMaternal fluoride exposure, as measured by serum fluoride concentrations in a small, but representative sample of women from northern California, USA, showed significant changes in the second trimester cord blood proteome relative to maternal serum fluoride concentration.
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- 2024
23. MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program
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Lewis, Kimberly A, Stroebel, Benjamin M, Zhang, Li, Aouizerat, Bradley, Mattis, Aras N, and Flowers, Elena
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Medicinal and Biomolecular Chemistry ,Chemical Sciences ,Clinical Trials and Supportive Activities ,Nutrition ,Obesity ,Biotechnology ,Clinical Research ,Prevention ,Diabetes ,Metabolic and endocrine ,Good Health and Well Being ,Metformin ,Humans ,Female ,Diabetes Mellitus ,Type 2 ,Middle Aged ,Male ,MicroRNAs ,Hypoglycemic Agents ,Adult ,Biomarkers ,Prediabetic State ,diabetes risk ,diabetes prevention program ,microRNA ,metformin ,post-transcription ,Other Chemical Sciences ,Genetics ,Other Biological Sciences ,Chemical Physics ,Biochemistry and cell biology ,Microbiology ,Medicinal and biomolecular chemistry - Abstract
The Diabetes Prevention Program (DPP) randomized controlled trial demonstrated that metformin treatment reduced progression to type 2 diabetes (T2D) by 31% compared to placebo in adults with prediabetes. Circulating micro-ribonucleic acids (miRs) are promising biomarkers of T2D risk, but little is known about their associations with metformin regimens for T2D risk reduction. We compared the change in 24 circulating miRs from baseline to 2 years in a subset from DPP metformin intervention (n = 50) and placebo (n = 50) groups using Wilcoxon signed rank tests. Spearman correlations were used to evaluate associations between miR change and baseline clinical characteristics. Multiple linear regression was used to adjust for covariates. The sample was 73% female, 17% Black, 13% Hispanic, and 50 ± 11 years. Participants were obese, normotensive, prediabetic, and dyslipidemic. Change in 12 miR levels from baseline to 2 years was significantly different in the metformin group compared with placebo after adjusting for multiple comparisons: six (let-7c-5p, miR-151a-3p, miR-17-5p, miR-20b-5p, miR-29b-3p, and miR-93-5p) were significantly upregulated and six (miR-130b-3p, miR-22-3p, miR-222-3p, miR-320a-3p, miR-320c, miR-92a-3p) were significantly downregulated in the metformin group. These miRs help to explain how metformin is linked to T2D risk reduction, which may lead to novel biomarkers, therapeutics, and precision health strategies.
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- 2024
24. AFFIRMATIVE – REJECT. With and Against AI
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Kuhn, Mattis, primary
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- 2024
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25. 'I Help My Parents by Using Some of My FAFSA Money': A Qualitative Exploration of Pandemic-Related Stress among Community College Students
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Jacquelyn Chin, Samantha Mattis, Josceline Acosta, Amaranta Ramirez, David Rivera, Adrian Valadez, Kathleen Baca Leanos, Isaiah Jones, and Alison Cerezo
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The coronavirus (COVID-19) global pandemic upended the academic trajectories and opportunities of many community college students in the United States. While four-year universities have seen an uptick in applications in the 2021-2022 academic year, community colleges have experienced a sharp decrease in enrollment, signifying significant challenges to students' life circumstances. In May 2020, we sampled 116 community college students (M[subscript age] 23.08; SD = 7.17) attending Hispanic Serving Institutions in California. The online survey gathered: (a) in-depth demographic information, including pandemic-related changes to students' academic and financial standing, and (b) qualitative data on pandemic-related stress. Given the novelty of the COVID-19 pandemic in May 2020, the overarching goal of this study was to conduct a broad needs assessment of community college students' experiences. Data highlighted significant socio-emotional challenges, financial hardship, and both current and projected academic delays. Community college students described severe challenges across financial, socio-emotional and academic areas. Data that capture first-hand qualitative descriptions of COVID-19 stress are necessary to inform the allocation of critical resources and policies to improve the well-being of community college students.
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- 2024
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26. Information-Theoretic Characterization of Vowel Harmony: A Cross-Linguistic Study on Word Lists
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Steuer, Julius, Abdullah, Badr, List, Johann-Mattis, and Klakow, Dietrich
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Computer Science - Computation and Language - Abstract
We present a cross-linguistic study that aims to quantify vowel harmony using data-driven computational modeling. Concretely, we define an information-theoretic measure of harmonicity based on the predictability of vowels in a natural language lexicon, which we estimate using phoneme-level language models (PLMs). Prior quantitative studies have relied heavily on inflected word-forms in the analysis of vowel harmony. We instead train our models using cross-linguistically comparable lemma forms with little or no inflection, which enables us to cover more under-studied languages. Training data for our PLMs consists of word lists with a maximum of 1000 entries per language. Despite the fact that the data we employ are substantially smaller than previously used corpora, our experiments demonstrate the neural PLMs capture vowel harmony patterns in a set of languages that exhibit this phenomenon. Our work also demonstrates that word lists are a valuable resource for typological research, and offers new possibilities for future studies on low-resource, under-studied languages., Comment: Presented at SIGTYP at EACL 2023
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- 2023
27. Quantum control of a cat-qubit with bit-flip times exceeding ten seconds
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Réglade, Ulysse, Bocquet, Adrien, Gautier, Ronan, Cohen, Joachim, Marquet, Antoine, Albertinale, Emanuele, Pankratova, Natalia, Hallén, Mattis, Rautschke, Felix, Sellem, Lev-Arcady, Rouchon, Pierre, Sarlette, Alain, Mirrahimi, Mazyar, Campagne-Ibarcq, Philippe, Lescanne, Raphaël, Jezouin, Sébastien, and Leghtas, Zaki
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Quantum Physics - Abstract
Quantum bits (qubits) are prone to several types of errors due to uncontrolled interactions with their environment. Common strategies to correct these errors are based on architectures of qubits involving daunting hardware overheads. A hopeful path forward is to build qubits that are inherently protected against certain types of errors, so that the overhead required to correct remaining ones is significantly reduced. However, the foreseen benefit rests on a severe condition: quantum manipulations of the qubit must not break the protection that has been so carefully engineered. A recent qubit - the cat-qubit - is encoded in the manifold of metastable states of a quantum dynamical system, thereby acquiring continuous and autonomous protection against bit-flips. Here, in a superconducting circuit experiment, we implement a cat-qubit with bit-flip times exceeding 10 seconds. This is a four order of magnitude improvement over previous cat-qubit implementations. We prepare and image quantum superposition states, and measure phase-flip times above 490 nanoseconds. Most importantly, we control the phase of these quantum superpositions without breaking bit-flip protection. This experiment demonstrates the compatibility of quantum control and inherent bit-flip protection at an unprecedented level, showing the viability of these dynamical qubits for future quantum technologies.
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- 2023
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28. Bullet ant – mehr als nur ein schmerzhafter Stich
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Zierold, Sarah, Bertlich, Mattis, and Oppel, Eva Maria
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- 2024
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29. Universal and cultural factors shape body part vocabularies
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Tjuka, Annika, Forkel, Robert, and List, Johann-Mattis
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- 2024
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30. Prospective de novo drug design with deep interactome learning
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Atz, Kenneth, Cotos, Leandro, Isert, Clemens, Håkansson, Maria, Focht, Dorota, Hilleke, Mattis, Nippa, David F., Iff, Michael, Ledergerber, Jann, Schiebroek, Carl C. G., Romeo, Valentina, Hiss, Jan A., Merk, Daniel, Schneider, Petra, Kuhn, Bernd, Grether, Uwe, and Schneider, Gisbert
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- 2024
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31. AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis
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Shihan, Mahbubul H., Sharma, Sachin, Cable, Carson, Prathigudupu, Vijaya, Chen, Alina, Mattis, Aras N., and Chen, Jennifer Y.
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- 2024
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32. Passive or active drainage system for chronic subdural haematoma—a single-center retrospective follow-up study
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Majewska, Paulina, Madsbu, Mattis A., Sagberg, Lisa Millgård, Gulati, Sasha, Jakola, Asgeir Store, and Solheim, Ole
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- 2024
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33. A comparative wordlist for investigating distant relations among languages in Lowland South America
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Blum, Frederic, Barrientos, Carlos, Zariquiey, Roberto, and List, Johann-Mattis
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- 2024
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34. Allergenspezifische Immuntherapie: Ein kurzer Überblick im Zusammenhang mit der allergischen Konjunktivitis
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Lill, Diana, Bertlich, Mattis, and Oppel, Eva
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- 2024
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35. Plug-and-play measurement of chromatic dispersion by means of two-photon interferometry
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Dalidet, Romain, Martin, Anthony, Riesner, Mattis, Ahmedou, Sidi-Ely, Dauliat, Romain, Leconte, Baptiste, Walter, Guillaume, Sauder, Grégory, Delagnes, Jean-Christophe, Millot, Guy, Roy, Philippe, Jamier, Raphaël, Tanzilli, Sébastien, and Labonté, Laurent
- Subjects
Quantum Physics - Abstract
Since the first proof-of-principle experiments 25 years ago, quantum metrology has matured from fundamental concepts to versatile and powerful tools in a large variety of research branches, such as gravitational-wave detection, atomic clocks, plasmonic sensing, and magnetometry. At the same time, two-photon interferometry, which underpins the possibility of entanglement to probe optical materials with unprecedented levels of precision and accuracy, holds the promise to stand at the heart of innovative functional quantum sensing systems. We report a novel quantum-based method for measuring the frequency dependence of the velocity in a transparent medium, i.e, the chromatic dispersion (CD). This technique, using energy-time entangled photons, allows straightforward access to CD value from the visibility of two-photon fringes recorded in a free evolution regime. In addition, our quantum approach features all advantages of classical measurement techniques, i.e, flexibility and accuracy, all in a plug-and-play system.
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- 2023
36. Orientation relationship of FeNiC and FeNiCSi from variant detection in EBSD data
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Seehaus, Mattis, Pei, Risheng, Korte-Kerzel, Sandra, and Sandlöbes-Haut, Stefanie
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Condensed Matter - Materials Science - Abstract
The determination of orientation relationships in dual or multi-phase materials is very important in the field of interface engineering for the design of materials with tailored properties. In this work, a code is developed for the automated and statistical analysis of the orientation relationship of electron backscatter diffraction data. On the example of Fe-Ni-(Si)-C alloys containing lenticular martensite and retained austenite, the code is applied and it is shown that the orientation relationship (OR) corresponds to the Greninger-Troiano OR and that a statistically reliable investigation of the OR between the retained austenite and the related martensite variants is feasible using the code developed in this study., Comment: in revision currently in Crystals
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- 2023
- Full Text
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37. Trimming Phonetic Alignments Improves the Inference of Sound Correspondence Patterns from Multilingual Wordlists
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Blum, Frederic and List, Johann-Mattis
- Subjects
Computer Science - Computation and Language - Abstract
Sound correspondence patterns form the basis of cognate detection and phonological reconstruction in historical language comparison. Methods for the automatic inference of correspondence patterns from phonetically aligned cognate sets have been proposed, but their application to multilingual wordlists requires extremely well annotated datasets. Since annotation is tedious and time consuming, it would be desirable to find ways to improve aligned cognate data automatically. Taking inspiration from trimming techniques in evolutionary biology, which improve alignments by excluding problematic sites, we propose a workflow that trims phonetic alignments in comparative linguistics prior to the inference of correspondence patterns. Testing these techniques on a large standardized collection of ten datasets with expert annotations from different language families, we find that the best trimming technique substantially improves the overall consistency of the alignments. The results show a clear increase in the proportion of frequent correspondence patterns and words exhibiting regular cognate relations., Comment: The paper was accepted at the SIGTYP workshop 2023 co-located with EACL
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- 2023
38. Fluoride-related changes in the fetal cord blood proteome; a pilot study
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Sami T. Tuomivaara, Susan J. Fisher, Steven C. Hall, Dana E. Goin, Aras N. Mattis, and Pamela K. Den Besten
- Subjects
Industrial medicine. Industrial hygiene ,RC963-969 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Fluoride exposure during pregnancy has been associated with various effects on offspring, including changes in behavior and IQ. To provide clues to possible mechanisms by which fluoride may affect human fetal development, we completed proteomic analyses of cord blood serum collected from second-trimester pregnant women residing in northern California, USA. Objective To identify changes in cord blood proteins associated with maternal serum fluoride concentration in pregnant women. Methods The proteomes of 19 archived second-trimester cord blood samples from women living in northern California, USA, and having varied serum fluoride concentrations, were analyzed by quantitative mass spectrometry. The 327 proteins that were quantified were characterized by their abundance relative to maternal serum fluoride concentration, and subjected to pathway analyses using PANTHER and Ingenuity Pathway Analysis processes. Results Pathway analyses showed significant increases in process related to reactive oxygen species and cellular oxidant detoxification, associated with increasing maternal serum fluoride concentrations. Pathways showing significant decreases included complement cascade, suggesting alterations in alterations in process associated with inflammation. Conclusion Maternal fluoride exposure, as measured by serum fluoride concentrations in a small, but representative sample of women from northern California, USA, showed significant changes in the second trimester cord blood proteome relative to maternal serum fluoride concentration.
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- 2024
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39. Spatial tumor immune microenvironment phenotypes in ovarian cancer
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Claudia Mateiou, Lavanya Lokhande, Lan Hoa Diep, Mattis Knulst, Elias Carlsson, Sara Ek, Karin Sundfeldt, and Anna Gerdtsson
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Immunotherapy has largely failed in ovarian carcinoma (OC), likely due to that the vast tumor heterogeneity and variation in immune response have hampered clinical trial outcomes. Tumor-immune microenvironment (TIME) profiling may aid in stratification of OC tumors for guiding treatment selection. Here, we used Digital Spatial Profiling combined with image analysis to characterize regions of spatially distinct TIME phenotypes in OC to assess whether immune infiltration pattern can predict presence of immuno-oncology targets. Tumors with diffuse immune infiltration and increased tumor-immune spatial interactions had higher presence of IDO1, PD-L1, PD-1 and Tim-3, while focal immune niches had more CD163 macrophages and a preliminary worse outcome. Immune exclusion was associated with presence of Tregs and Fibronectin. High-grade serous OC showed an overall stronger immune response and presence of multiple targetable checkpoints. Low-grade serous OC was associated with diffuse infiltration and a high expression of STING, while endometrioid OC had higher presence of CTLA-4. Mucinous and clear cell OC were dominated by focal immune clusters and immune-excluded regions, with mucinous tumors displaying T-cell rich immune niches.
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- 2024
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40. Metabolomic profiling of upper GI malignancies in blood and tissue: a systematic review and meta-analysis
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Balonov, Ilja, Mattis, Minca, Jarmusch, Stefanie, Koletzko, Berthold, Heinrich, Kathrin, Neumann, Jens, Werner, Jens, Angele, Martin K., Heiliger, Christian, and Jacob, Sven
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- 2024
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41. Examining Mental Health, Academic, and Economic Stressors During the COVID-19 Pandemic Among Community College and 4-Year University Students.
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Ramirez, Amaranta, Rivera, David, Valadez, Adrian, Mattis, Samantha, and Cerezo, Alison
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COVID-19 ,Coronavirus ,community college students ,economic stress ,mental health - Abstract
Objective: The COVID-19 global pandemic has created severe, long-lasting challenges to college students in the United States (US). In the present study, we assessed mental health symptomatology (depression, anxiety, life stress), academic challenges, and economic stress during the first wave of the Coronavirus pandemic. Method: A total sample of 361 college students (Mage = 22.26, SD = 5.56) was gathered from a community college (N = 134) and mid-size public university (N = 227) in Southwest US, both designated as Hispanic Serving Institutions. Results: Pearson and point biserial correlations indicated associations between mental health symptomatology, academic challenges, and economic stress, including expected delays in graduation. Multivariate analysis revealed that community college students had statistically significantly higher scores on anxiety F(1, 312) = 5.27, p = .02, ηp2 = .01 than 4-year university students, as well as key differences with respect to academic challenges. Chi Square analyses revealed that Latinx families experienced greater economic hardships, including job loss or reduced work hours (χ2 (1, N = 361) = 28.56, p = .00) than other ethnic/racial groups. Conclusions/Contributions: Findings revealed that community college students faced disparately negative mental health symptomatology, academic challenges, and economic stress during the first wave of the Coronavirus pandemic. Further, Latinx students families experienced significant economic hardship that may have impacted students academic progress and future planning.
- Published
- 2023
42. Inference of Partial Colexifications from Multilingual Wordlists
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List, Johann-Mattis
- Subjects
Computer Science - Computation and Language - Abstract
The past years have seen a drastic rise in studies devoted to the investigation of colexification patterns in individual languages families in particular and the languages of the world in specific. Specifically computational studies have profited from the fact that colexification as a scientific construct is easy to operationalize, enabling scholars to infer colexification patterns for large collections of cross-linguistic data. Studies devoted to partial colexifications -- colexification patterns that do not involve entire words, but rather various parts of words--, however, have been rarely conducted so far. This is not surprising, since partial colexifications are less easy to deal with in computational approaches and may easily suffer from all kinds of noise resulting from false positive matches. In order to address this problem, this study proposes new approaches to the handling of partial colexifications by (1) proposing new models with which partial colexification patterns can be represented, (2) developing new efficient methods and workflows which help to infer various types of partial colexification patterns from multilingual wordlists, and (3) illustrating how inferred patterns of partial colexifications can be computationally analyzed and interactively visualized.
- Published
- 2023
43. Detecting Lexical Borrowings from Dominant Languages in Multilingual Wordlists
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Miller, John E. and List, Johann-Mattis
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Computer Science - Computation and Language - Abstract
Language contact is a pervasive phenomenon reflected in the borrowing of words from donor to recipient languages. Most computational approaches to borrowing detection treat all languages under study as equally important, even though dominant languages have a stronger impact on heritage languages than vice versa. We test new methods for lexical borrowing detection in contact situations where dominant languages play an important role, applying two classical sequence comparison methods and one machine learning method to a sample of seven Latin American languages which have all borrowed extensively from Spanish. All methods perform well, with the supervised machine learning system outperforming the classical systems. A review of detection errors shows that borrowing detection could be substantially improved by taking into account donor words with divergent meanings from recipient words., Comment: To appear at The 17th Conference of the European Chapter of the Association for Computational Linguistics. See https://www.aclweb.org/portal/content/17th-conference-european-chapter-association-computational-linguistics
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- 2023
44. You can bring plankton to fecal indicator organisms, but you cannot make the plankton graze: particle contribution to E. coli and MS2 inactivation in surface waters
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Lauren C. Kennedy, Ava M. Mattis, and Alexandria B. Boehm
- Subjects
fecal indicator organism ,persistence ,grazer ,plankton ,surface water ,environmental water ,Microbiology ,QR1-502 - Abstract
ABSTRACT Organisms that are associated with feces (“fecal indicator organisms”) are monitored to assess the potential for fecal contamination of surface water bodies in the United States. However, the effect of the complex mixtures of chemicals and the natural microbial community within surface water (“particles”) on fecal indicator organism persistence is not well characterized. We aimed to better understand how particles, including biological (e.g., potential grazers) and inert (e.g., minerals) types, affect the fecal indicator organisms Escherichia coli K-12 (“E. coli”) and bacteriophage MS2 in surface waters. A gradient of particles captured by a 0.2-µm-pore-size filter (“large particles”) was generated, and the additional particles and dissolved constituents that passed through the filter were deemed “small particles.” We measured the ratio of MS2 and E. coli that survived over a 24-h incubation period for each condition (0%–1,000% large-particle concentration in raw water) and completed a linear regression that included large- and small-particle coefficients. Particles were characterized by quantifying plankton, total bacterial cells, and total solids. E. coli and MS2 persistence was not significantly affected by large particles, but small particles had an effect in most waters. Small particles in higher-salinity waters had the largest, negative effect on E. coli and MS2 survival ratios: Significant small-particle coefficients ranged from −1.7 to −5.5 day−1 in the marine waters and −0.89 to −3.2 day−1 in the fresh and estuarine waters. This work will inform remediation efforts for impaired surface water bodies.IMPORTANCEMany surface water bodies in the United States have organisms associated with fecal contamination that exceed regulatory standards and prevent safe recreation. The process to remediate impaired water bodies is complicated because these fecal indicator organisms are affected by the local environmental conditions. For example, the effect of particles in surface water on fecal indicator concentrations are difficult to quantify in a way that is comparable between studies and water bodies. We applied a method that overcomes this limitation to assess the effects of large particles, including natural plankton that could consume the seeded fecal indicator organisms. Even in environmental water samples with diverse communities of plankton present, no effect of large particles on fecal indicator concentrations was observed. These findings have implications for the interpretation and design of future studies, including that particle characterization of surface water may be necessary to assess the fate of fecal indicators.
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- 2024
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45. Umkämpfte Meilensteine - Rechtsstaatlichkeitskonditionalität bei NextGenerationEU
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Mattis Leson
- Subjects
Europäischer Aufbauplan ,2020 ,Konditionalität ,NextGenerationEU ,Rechtsstaatlichkeit ,Rechtsstaatsmechanismus ,Law - Abstract
Am 28. August 2024 haben vier Richterverbände bekanntgegeben, dass sie Berufung gegen den Medel-Beschluss des Gerichts der Europäischen Union eingelegt haben. Das Verfahren verdient bereits deshalb Aufmerksamkeit, weil es wieder einmal das ewige Thema des Individualrechtsschutzes vor den Gerichten der Europäischen Union betrifft. Darüber hinaus – und von noch größerer Relevanz – wirft die Rechtssache wichtige, unbeantwortete materielle Fragen der Rechtsstaatskonditionalität auf. Insbesondere steht die Wirksamkeit des Instituts erneut auf dem Prüfstand – verhandelt erstmals im Kontext von NextGenerationEU.
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- 2024
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46. Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy
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Wenxi Yu, Sophie F. Hill, Limei Zhu, Yiannos Demetriou, Faith Reger, Joanna Mattis, and Miriam H. Meisler
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hippocampus ,snRNA-seq ,Sodium channel ,shRNA ,Gene therapy ,Epilepsy ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Gain-of-function mutations in SCN8A cause developmental and epileptic encephalopathy (DEE), a disorder characterized by early-onset refractory seizures, deficits in motor and intellectual functions, and increased risk of sudden unexpected death in epilepsy. Altered activity of neurons in the corticohippocampal circuit has been reported in mouse models of DEE. We examined the effect of chronic seizures on gene expression in the hippocampus by single-nucleus RNA sequencing in mice expressing the patient mutation SCN8A-p.Asn1768Asp (N1768D). One hundred and eighty four differentially expressed genes were identified in dentate gyrus granule cells, many more than in other cell types. Electrophysiological recording from dentate gyrus granule cells demonstrated an elevated firing rate. Targeted reduction of Scn8a expression in the dentate gyrus by viral delivery of an shRNA resulted in doubling of median survival time from 4 months to 8 months, whereas delivery of shRNA to the CA1 and CA3 regions did not result in lengthened survival. These data indicate that granule cells of the dentate gyrus are a specific locus of pathology in SCN8A-DEE.
- Published
- 2024
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47. Towards Privacy-Preserving Relational Data Synthesis via Probabilistic Relational Models.
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Malte Luttermann, Ralf Möller 0001, and Mattis Hartwig
- Published
- 2024
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48. Are Sounds Sound for Phylogenetic Reconstruction?
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Luise Häuser, Gerhard Jäger, Johann-Mattis List, Taraka Rama, and Alexandros Stamatakis
- Published
- 2024
49. A Computational Model for the Assessment of Mutual Intelligibility Among Closely Related Languages.
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Jessica Nieder and Johann-Mattis List
- Published
- 2024
50. Aggregating Predicted Individual Hospital Length of Stay to Predict Bed Occupancy for Hospitals.
- Author
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Mattis Hartwig, Simon Schiff, Sebastian Wolfrum, and Ralf Möller 0001
- Published
- 2024
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