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2. Exploring the association between phase angle of bioimpedance at 50 kHz and cardiovascular risk

Author

Evandro Lucas de Borba, Cristina Wichbold, Jamile Ceolin, Marcelo Rodrigues Gonçalves, Wilson Cañon-Montañez, Alexandre Vontobel Padoin, and Rita Mattiello

Subjects
Bioelectrical Impedance Analysis, Cardiovascular Disease, Phase Angle, Cardiovascular Risk Calculator, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Cardiovascular diseases are characterized by chronic inflammation, leading to increased inflammatory markers that can cause cell damage and death. Phase angle has emerged as a marker of cellular health. It is considered a prognostic factor in various acute and chronic conditions. However, few studies have examined its association with cardiovascular disease risk measures. This study aims to investigate the relationship between phase angle, the general Framingham risk score, and the HEARTS cardiovascular risk score. Methods This cross-sectional study included a convenience sample of adult patients of 2 primary health care services. Phase angle was measured using multifrequency bioimpedance analysis at 50 kHz. The risk of cardiovascular events was calculated using the Framingham and HEARTS risk scores. Statistical analysis included generalized linear regression models, unadjusted and adjusted according to sex and age, to determine the association between scores, risk factors, and phase angle. Results The study included 164 individuals with a mean age 52.2 (SD 17.9). According to the HEARTS score, low-risk patients had higher phase angle values than those with high or very high risk [ß = -0.57 (95% CI -0.95; -0.19), P = 0.003]. Framingham scores showed a trend toward significance for higher mean phase angle values in low-risk than high-risk patients [ß = -0.43 (95% CI -0.88 to 0.02), P = 0.06]. Conclusion Phase angle values were lower in high and very high-risk patients than in low-risk patients, which shows that phase angle is a promising risk predictor for patients with cardiovascular diseases.

Published
2024
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3. Environmental pollutants as risk factors for autism spectrum disorders: a systematic review and meta-analysis of cohort studies

Author

Tatiana Duque-Cartagena, Marcello Dala Bernardina Dalla, Eduardo Mundstock, Felipe Kalil Neto, Sergio Angelo Rojas Espinoza, Sara Kvitko de Moura, Gabriele Zanirati, Alexandre Vontobel Padoin, Juan Gabriel Piñeros Jimenez, Airton Tetelbom Stein, Wilson Cañon-Montañez, and Rita Mattiello

Subjects
Autism, Environmental pollutants, Systematic review, Cohort studies, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental condition affecting communication, social interaction, and behavior. Evidence suggests that environmental pollutants are associated with ASD incidence. This review aimed to analyze the effect of environmental pollutants on ASD. Methods Systematic review and meta-analysis of cohort studies evaluated the association between exposure to environmental pollutants and ASD. We searched COCHRANE CENTRAL, MEDLINE, CINAHL, LILACS, EMBASE, PsycINFO, Web of Science, SciELO, and gray literature from inception to January 2023. The model used for meta-analysis was inverse variance heterogeneity (IVhet). The effect measures were the beta coefficient (β) and the relative risk (RR) with their 95% confidence intervals (95% CI). Sensitivity analyses were carried out using an instrument to screen or diagnose autism. Results A total of 5,780 studies were identified; 27 were included in the systematic review, and 22 were included in the meta-analysis. These studies included 1,289,183 participants and 129 environmental pollutants. Individual meta-analyses found a significant association between nitrogen dioxide RR = 1.20 (95% CI: 1.03 to 1.38; I2: 91%), copper RR = 1.08 (95% CI: 1.03 to 1.13; I2: 0%), mono-3-carboxy propyl phthalate β = 0.45 (95% CI: 0.20 to 0.70; I2: 0%), monobutyl phthalate β = 0.43 (95% CI: 0.13 to 0.73; I2: 0%) and polychlorinated biphenyl (PCB) 138 RR = 1.84 (95% CI: 1.14 to 2.96; I2:0%) with ASD. Subgroup meta-analyses found a significant association with carbon monoxide RR = 1.57 (95% CI: 1.25 to 1.97; I2: 0%), nitrogen oxides RR = 1.09 (95% CI: 1.04 to 1.15; I2: 34%) and metals RR = 1.13 (95% CI: 1.01 to 1.27; I2:24%). Conclusion This study found positive associations nitrogen dioxide, copper, mono-3-carboxypropyl phthalate, monobutyl phthalate, and PCB 138, and the development of ASD, likewise, with subgroups of pollutants carbon monoxide, nitrogen oxides, and metals. Therefore, it is important to identify these risk factors in children and adolescents to contribute to ASD and identify prevention strategies effectively.

Published
2024
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4. Concurrent Validity and Reliability of Video-Based Approach to Assess Physical Function in Adults With Knee Osteoarthritis

Author

Aily, Jessica B., da Silva, Alyssa Conte, Noronha, Marcos de, White, Daniel K., and Mattiello, Stela M.

Subjects
Therapeutics, Physiological -- Complications and side effects -- Patient outcomes, Physical therapy -- Complications and side effects -- Patient outcomes, Osteoarthritis -- Care and treatment -- Patient outcomes
Abstract

Objectives. The aim of this study was to determine the concurrent validity and reliability of the Osteoarthritis Research Society International recommended performance-based tests delivered by video-based in adults with knee osteoarthritis. Methods. Thirty-two participants (aged 40-70 years; 15 men) undertook assessments of 4 performance-based tests via both video-based (real-time and recorded) and face-to-face approaches, on the same day. Outcome measures were performance-based test and the number of technical issues encountered. The performance-based tests included the 40-Meter Fast-Paced Walk Test (velocity, m/s), the 30-Second Chair Stand Test (number of repetitions), the Stair Climb Test (time, seconds), and the Timed "Up & Go" Test (time, seconds). The Bland-Altman limit of agreement measures, standard error of measurement (SEM), coefficient of variation (CV), minimal detectable changes, and bias (mean difference) were employed to analyze the concurrent validity between video-based and face-to-face approaches of the performance-based tests. Reliability was measured using intraclass correlation coefficients, CV, and SEM. Results. A high degree of concurrent validity for the Timed "Up & Go" Test (bias =-0.22), the 30-Second Chair Stand Test (bias =-0.22), the Stair Climb Test (bias = -0.31), and the 40-Meter Fast-Paced Walk Test (bias =-0.06) was found. SEM and CV values were within the acceptable level for concurrent validity. There was a high degree of reliability demonstrated for all tests analyzed. Intraclass correlation coefficient measures ranged from 0.95 to 1.00 for intrarater reliability, and from 0.95 to 0.99 for interrater reliability. Conclusions. Video-based assessment of physical performance tests is a valid and reliable tool for measuring physical function among adults with knee osteoarthritis via Microsoft Teams (Microsoft Corp, Redmond, WA, USA). Impact. Video-based assessment is a promising public health tool to measure physical function in adults with knee osteoarthritis. Keywords: Digital Technology, Knee Osteoarthritis, Video-Based Assessment, Virtual Rehabilitation, Introduction Physical therapist care has traditionally been delivered through face-to-face consultations. However, for many people, access to physical therapy is limited by geographic isolation, limited local services, or difficulty in [...]

Published
2024
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5. Evaluation of inter-observer reliability in the case of trichotomous and four-level animal-based welfare indicators with two observers

Author

Benedetta Torsiello, Mauro Giammarino, Piero Quatto, Monica Battini, Silvana Mattiello, Luca Battaglini, and Manuela Renna

Subjects
agreement index, animal-based measure, inter-observer reliability, bootstrap method, three- and four-level indicators, Animal culture, SF1-1100
Abstract

This study focuses on assessing inter-observer reliability (IOR) between two observers in the case of trichotomous and four-level animal-based welfare indicators assessed at individual level. The Body Condition Score (BCS) and Knee calluses (KNC) were chosen as trichotomous indicators; data were collected in fourteen intensively managed dairy goat farms in Italy (ITF1 to ITF7) and Portugal (PTF1 to PTF7) and in extensively managed dairy goat farms exploiting three alpine pastures (AP1, AP2 and AP3) in Italy. The Ear posture (EP) and Eye white (EW) were chosen as four-level indicators; data were collected in three intensively managed dairy cattle farms (F1, F2 and F3) in Italy. The performance of the most documented agreement indices was compared. In the case of trichotomous indicators, Scott’s π, Cohen’s K, Cohen’s KC, Cohen’s weighted K and Krippendorff’s α were affected by the paradox effect: when the concordance rate (P0) was high, they sometimes gave very low or even negative values (e.g. P0(BCS-ITF3) = 74%; Scott’s π = 0.05; Cohen’s K = 0.09; Krippendorff’s α = 0.06; P0(BCS-AP3) = 74%; Scott’s π = −0.12; Cohen’s K = Krippendorff’s α = −0.11). Bangdiwala’s B, Gwet’s γ(AC1) and Quatto’s weighted S were not affected by this phenomenon and provided values very close to P0 (e.g. P0(KNC-PTF1) = 88%; Bangdiwala’s B = Gwet’s γ(AC1) = 0.85; P0(BCS-AP1) = 82%; Bangdiwala’s B = Gwet’s γ(AC1) = 0.79). In the case of four-level indicators, Cohen’s K and Krippendorff’s α were not affected by the paradox behaviour. However, Cohen’s KC in some cases exceeded the observed P0 (e.g. P0(EP-F3) = 78%; Cohen’s KC = 1). Gwet’s γ(AC1) showed the best results for four-level indicators (e.g. P0(EP-F1) = 88%; Gwet’s γ(AC1) = 0.86), followed by Quatto’s S and Holley and Guilford’s G (e.g. P0(EP-F1) = 88%; Quatto’s S = Holley and Guilford’s G = 0.84). To evaluate IOR between two observers, Bangdiwala’s B, Gwet’s γ(AC1) and Quatto’s weighted S are suggested for trichotomous indicators, while Gwet’s γ(AC1), Quatto’s S and Holley and Guilford’s G are suggested for four-level indicators.

Published
2024
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11. The Telephone Language Screener (TLS): standardization of a novel telephone-based screening test for language impairment

Author

Aiello, Edoardo Nicolò, Pucci, Veronica, Diana, Lorenzo, Corvaglia, Alessia, Niang, Aida, Mattiello, Silvia, Preti, Alice Naomi, Durante, Giorgia, Ravelli, Adele, Consonni, Lucia, Guerra, Carolina, Ponti, Adriana Delli, Sangalli, Gaia, Difonzo, Teresa, Scarano, Stefano, Perucca, Laura, Zago, Stefano, Appollonio, Ildebrando, Mondini, Sara, and Bolognini, Nadia

Published
2024
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12. Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Author

Musella, Martina, Guarracino, Andrea, Manduca, Nicoletta, Galassi, Claudia, Ruggiero, Eliana, Potenza, Alessia, Maccafeo, Ester, Manic, Gwenola, Mattiello, Luca, Soliman Abdel Rehim, Sara, Signore, Michele, Pietrosanto, Marco, Helmer-Citterich, Manuela, Pallocca, Matteo, Fanciulli, Maurizio, Bruno, Tiziana, De Nicola, Francesca, Corleone, Giacomo, Di Benedetto, Anna, Ercolani, Cristiana, Pescarmona, Edoardo, Pizzuti, Laura, Guidi, Francesco, Sperati, Francesca, Vitale, Sara, Macchia, Daniele, Spada, Massimo, Schiavoni, Giovanna, Mattei, Fabrizio, De Ninno, Adele, Businaro, Luca, Lucarini, Valeria, Bracci, Laura, Aricò, Eleonora, Ziccheddu, Giovanna, Facchiano, Francesco, Rossi, Stefania, Sanchez, Massimo, Boe, Alessandra, Biffoni, Mauro, De Maria, Ruggero, Vitale, Ilio, and Sistigu, Antonella

Published
2024
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13. Bone char: characterization and agronomic application as an alternative source of phosphorus

Author

Gustavo Franco de Castro, Valber Georgio de Oliveira Duarte, Fabiane Carvalho Ballotin, Brunno Cesar Pereira Rocha, Igor Franco Rezende, Edson Marcio Mattiello, Lucas Pereira Ribeiro do Vale, Gustavo Soares de Oliveira, Renê Chagas da Silva, and Jairo Tronto

Subjects
bovine bone, pyrolysis, phosphate fertilizer, slow release, Agriculture (General), S1-972
Abstract

ABSTRACT Alternative materials can be used to reduce reliance on mining for P-based fertilizers. In this sense, the pyrolysis process of bovine bones produces the “bone char”, which can be used as a source of P. This study aimed to characterize bone char and conduct a comparative analysis with both soluble (triple superphosphate) and non-soluble (Bayóvar phosphate rock) phosphate fertilizers, specifically examining its behavior in soil and uptake by plants. Bone char characterization was performed by X-ray diffraction (XRD), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and scanning electron microscopy coupled with energy-dispersive (SEM-EDS). The XRD analyses have shown the presence of hydroxyapatite in the bone char, bands assigned to P-O stretching from phosphate have been observed in ATR-FTIR, and Ca, P, C, and O elements were identified in the materials by EDS analyses. Solubility from fertilizer extractants was higher for bone char compared to Bayóvar, and both sources showed lower solubility compared to triple superphosphate. Cumulative amount of P released from bone char was higher than Bayóvar and lower than triple superphosphate. Amount of total dry matter, total shoot P uptake, and total shoot Ca uptake were higher for triple superphosphate compared to bone char and Bayóvar. Release profile of P from bone char strongly suggests this material can be used as a slow-release P source, with intermediate solubility between soluble and non-soluble commercialized sources.

Published
2024
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14. Melting of the two-dimensional solid phase in the Gaussian-core model

Author

Mendoza-Coto, Alejandro, Mattiello, Valéria, Cenci, Rômulo, Defenu, Nicolò, and Nicolao, Lucas

Subjects
Condensed Matter - Statistical Mechanics, Condensed Matter - Soft Condensed Matter
Abstract

A general theory for the melting of two dimensional solids explaining the universal and non-universal properties is an open problem up to date. Although the celebrated KTHNY theory have been able to predict the critical properties of the melting transition in a variety cases, it is already known that it is not able to capture the occurrence of first order transitions observed in certain systems as well as it doesn't provide a clear way to calculate the melting temperature for a specific model. In the present work we have developed an analytical method that combines Self Consistent Variational Approximation with the Renormalization Group in order to deal simultaneously with the phonon fluctuations and the topological defects present in the melting process of two dimensional crystals. The method was applied with impressive success to the study of the phase diagram of the Gaussian-core model, capturing not only the reentrant feature of its 2D solid phase, but also the related critical temperatures as a function of the density in quantitative detail. The developed method can be directly applied to study the melting of any hexagonal simple crystal formed by particles interacting through any finite pairwise interaction potential. Additionally, it has the potential to explain the occurrence of first order transitions in the melting process of two dimensional crystals.

Published
2022
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15. Enhancing recovery from gut microbiome dysbiosis and alleviating DSS-induced colitis in mice with a consortium of rare short-chain fatty acid-producing bacteria

Author

Achuthan Ambat, Linto Antony, Abhijit Maji, Sudeep Ghimire, Samara Mattiello, Purna C. Kashyap, Sunil More, Vanessa Sebastian, and Joy Scaria

Subjects
Microbiome, colitis, short chain fatty acid, butyrate, low abundant species, defined bacterial therapy, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

The human gut microbiota is a complex community comprising hundreds of species, with a few present in high abundance and the vast majority in low abundance. The biological functions and effects of these low-abundant species on their hosts are not yet fully understood. In this study, we assembled a bacterial consortium (SC-4) consisting of B. paravirosa, C. comes, M. indica, and A. butyriciproducens, which are low-abundant, short-chain fatty acid (SCFA)-producing bacteria isolated from healthy human gut, and tested its effect on host health using germ-free and human microbiota-associated colitis mouse models. The selection also favored these four bacteria being reduced in abundance in either Ulcerative Colitis (UC) or Crohn’s disease (CD) metagenome samples. Our findings demonstrate that SC-4 can colonize germ-free (GF) mice, increasing mucin thickness by activating MUC-1 and MUC-2 genes, thereby protecting GF mice from Dextran Sodium Sulfate (DSS)-induced colitis. Moreover, SC-4 aided in the recovery of human microbiota-associated mice from DSS-induced colitis, and intriguingly, its administration enhanced the alpha diversity of the gut microbiome, shifting the community composition closer to control levels. The results showed enhanced phenotypes across all measures when the mice were supplemented with inulin as a dietary fiber source alongside SC-4 administration. We also showed a functional redundancy existing in the gut microbiome, resulting in the low abundant SCFA producers acting as a form of insurance, which in turn accelerates recovery from the dysbiotic state upon the administration of SC-4. SC-4 colonization also upregulated iNOS gene expression, further supporting its ability to produce an increasing number of goblet cells. Collectively, our results provide evidence that low-abundant SCFA-producing species in the gut may offer a novel therapeutic approach to IBD.

Published
2024
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16. Patterns and determinants of the global herbivorous mycobiome

Author

Meili, Casey H, Jones, Adrienne L, Arreola, Alex X, Habel, Jeffrey, Pratt, Carrie J, Hanafy, Radwa A, Wang, Yan, Yassin, Aymen S, TagElDein, Moustafa A, Moon, Christina D, Janssen, Peter H, Shrestha, Mitesh, Rajbhandari, Prajwal, Nagler, Magdalena, Vinzelj, Julia M, Podmirseg, Sabine M, Stajich, Jason E, Goetsch, Arthur L, Hayes, Jerry, Young, Diana, Fliegerova, Katerina, Grilli, Diego Javier, Vodička, Roman, Moniello, Giuseppe, Mattiello, Silvana, Kashef, Mona T, Nagy, Yosra I, Edwards, Joan A, Dagar, Sumit Singh, Foote, Andrew P, Youssef, Noha H, and Elshahed, Mostafa S

Subjects
Microbiology, Biological Sciences, Evolutionary Biology, Animals, Mycobiome, Phylogeny, Feces, Digestive System, Biological Evolution, Mammals
Abstract

Despite their role in host nutrition, the anaerobic gut fungal (AGF) component of the herbivorous gut microbiome remains poorly characterized. Here, to examine global patterns and determinants of AGF diversity, we generate and analyze an amplicon dataset from 661 fecal samples from 34 mammalian species, 9 families, and 6 continents. We identify 56 novel genera, greatly expanding AGF diversity beyond current estimates (31 genera and candidate genera). Community structure analysis indicates that host phylogenetic affiliation, not domestication status and biogeography, shapes the community rather than. Fungal-host associations are stronger and more specific in hindgut fermenters than in foregut fermenters. Transcriptomics-enabled phylogenomic and molecular clock analyses of 52 strains from 14 genera indicate that most genera with preferences for hindgut hosts evolved earlier (44-58 Mya) than those with preferences for foregut hosts (22-32 Mya). Our results greatly expand the documented scope of AGF diversity and provide an ecologically and evolutionary-grounded model to explain the observed patterns of AGF diversity in extant animal hosts.

Published
2023

18. Exploring positive welfare measures: preliminary findings from a prototype protocol in loose housing dairy cattle farms

Author

Silvana Mattiello, Stefania Celozzi, Federica Manila Soli, and Monica Battini

Subjects
dairy cows, positive affects, animal emotions, behavior, animal welfare, housing, Veterinary medicine, SF600-1100
Abstract

IntroductionFollowing the increasing interest about the development of indicators of positive welfare and affective state in farm animals, the aim of this research is to present some preliminary results on the application of a prototype protocol based exclusively on positive welfare measures and to suggest potential benefits that can promote positive welfare.MethodsThe protocol was applied in 20 loose housing dairy cattle farms (6 on deep litter with straw, 14 in cubicles) and included only indicators of positive welfare and emotional states: feeding and resting synchronization, rumination during resting, comfortable lying postures, no visible eye white, relaxed ear postures, percentage of cow contacts with humans in the Avoidance Distance test. Potential benefits in terms of housing, feeding and management were then related to these variables (Mann-Whitney U test). Qualitative Behavior Assessment (QBA) was also carried out and analyzed by Principal Component Analysis to explore the effect of factors that were not evenly distributed in our sample (number of feed distributions, access to pasture, presence of paddock or environmental enrichments, automatic milking systems).ResultsWhen hay was included in the diet, higher feeding synchronization (93.7 ± 1.6 vs. 52.2 ± 4.7%; p 1 (72.1 ± 9.9 vs. 53.8 ± 5.8%), although differences were not significant (p = 0.14). Deep litter had a more positive effect than cubicles on comfort at resting, with a significantly higher percentage of ruminating cows (65.8 ± 10.2 vs. 34.2 ± 3.7%; p 1, hay in the diet and access to pasture) to enhance dairy cattle welfare.

Published
2024
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19. From ‘Covid-free’ to ‘Coronapocalypse’

Author

Elisa Mattiello

Subjects
neologisms, nonce words, Covid-19 discourse, hate speech, corpus analysis, American literature, PS1-3576, English literature, PR1-9680
Abstract

This study explores a dataset of Covid-related terms drawn from the Coronavirus Corpus (2020) in order to examine the impact of the crisis on language development in terms of novel words employed in popularisation discourse, namely online newspapers and magazines. The primary goals of the study are (1) to establish the stability, recognition and reusability of Covid-19 novel words (i.e. whether they are proper neologisms or nonce words), and (2) to investigate their main functions and effects. Results from a discourse-based analysis show that, on the one hand, new compounds (e.g. Covid-free) and regularly derived words (e.g. post-Covid) are used to disseminate information about the Covid-19 crisis to laymen and non-specialists. On the other hand, novel blends and similar creative words (e.g. coronapocalypse from ‘coronavirus’ and ‘apocalypse’) often have the function of breaking the tensions created by a difficult, even catastrophic scenario, but may also be used in the context of hate speech, to criticise or attack others, such as people ignoring stay-at-home orders and public health measures.

Published
2024
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21. Diffusion-free photon upconversion driven by intramolecular triplet-triplet annihilation in engineered conjugated chromophores

Author

Mattiello, Sara, Mecca, Sara, Ronchi, Alessandra, Calascibetta, Adiel, Mattioli, Giuseppe, Pallini, Francesca, Meinardi, Francesco, Beverina, Luca, and Monguzzi, Angelo

Subjects
Condensed Matter - Materials Science
Abstract

The photon upconversion based on sensitized triplet-triplet annihilation (sTTA-UC) is a spin-flip mechanism exploited to recover the energy of dark triplet states in conjugated systems. In this process a high-energy fluorescent singlet is created through the collision and fusion of two low-energy triplets belonging to different diffusing molecules. Its excellent yield in solution under low excitation intensity and non-coherent light highlighted the huge potential of sTTA-UC to provide a breakthrough in solar technologies. However, its diffusion-limited bi-molecular nature limits its efficiency in the solid state. To overcome this issue, we designed a molecular systems able to host simultaneously more than one triplet, thus enabling a diffusion-free intramolecular TTA. We obtain the first direct demonstration of intramolecular triplet fusion by tailored photoluminescence spectroscopy experiments, thus opening the way to realize a new family of single molecule upconverters with huge potential in solar and lightening technologies by accessing the natural triplets energy reservoir.

Published
2022

22. Heterogeneous Federated CubeSat System: problems, constraints and capabilities

Author

Batista, Carlos L G, Mattiello-Francisco, Fatima, and Pataricza, Andras

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Other Computer Science
Abstract

Different arguments were being presented in the last decade about CubeSats and their applications. Some of them address wireless communication (5G and 6G technologies) trying to achieve better characteristics as coverage and connectivity. Some arrived with terms as IoST (Internet of Space Things), Internet of Satellites (IoSat), DSS (Distributed Space Systems), and FSS (Federated Satellite Systems). All of them aim to use Small/NanoSatellites as constellations/swarms is to provide specific services, share unused resources, and evolve the concept of satellites-as-a-service (SaS). This paper aims to emophasize performance attributes of such cyber-physical systems, model their inherent operational constraints and at the very end, evaluate the quality of service in terms of figures of merit for the entering/leaving of new heterogeneous constituent systems, a.k.a satellites, to the constellation. This "whitepaper"-styled work focuses on presenting the definitions of this heterogeneous constellation problem, aims at its main capabilities and constraints, and proposes modeling approaches for this system representation and evaluation., Comment: 4 pages, 4 figures

Published
2022

23. Global, regional, and national stillbirths at 20 weeks' gestation or longer in 204 countries and territories, 1990–2021: findings from the Global Burden of Disease Study 2021

Author

Comfort, Haley, McHugh, Theresa A, Schumacher, Austin E, Harris, Ashley, May, Erin A, Paulson, Katherine R, Gardner, William M, Fuller, John E, Frisch, Meghan E, Taylor, Heather Jean, Leever, Andrew T, Teply, Corey, Verghese, Nicholas Alexander, Alam, Tahiya, Abate, Yohannes Habtegiorgis, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdissa, Daba, Abdoun, Meriem, Abdulkader, Rizwan Suliankatchi, Abebe, Mesfin, Abedi, Aidin, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abrigo, Michael R M, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Adane, Mesafint Molla, Addo, Isaac Yeboah, Adema, Bulcha Guye, Adesina, Miracle Ayomikun, Adetunji, Charles Oluwaseun Oluwaseun, Adeyinka, Daniel Adedayo, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Saira, Agampodi, Suneth Buddhika, Agodi, Antonella, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmadi, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ajami, Marjan, Akinosoglou, Karolina, Al Hasan, Syed Mahfuz, Al-Aly, Ziyad, Alam, Khurshid, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albashtawy, Mohammed, Alemi, Sharifullah, Algammal, Abdelazeem M, Al-Gheethi, Adel Ali Saeed, Ali, Abid, Ali, Liaqat, Ali, Mohammed Usman, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Almidani, Louay, Almustanyir, Sami, Altirkawi, Khalid A, Aly, Hany, Aly, Safwat, Amani, Reza, Ameyaw, Edward Kwabena, Amhare, Abebe Feyissa, Amin, Tarek Tawfik, Amiri, Sohrab, Andrei, Catalina Liliana, Andrei, Tudorel, Anoushiravani, Amir, Ansar, Adnan, Anvari, Davood, Anwer, Razique, Appiah, Francis, Arab-Zozani, Morteza, Aravkin, Aleksandr Y, Areda, Demelash, Aregawi, Brhane Berhe, Artamonov, Anton A, Aryal, Umesh Raj, Asemi, Zatollah, Asemu, Mulu Tiruneh, Asgedom, Akeza Awealom, Ashraf, Tahira, Asresie, Melash Belachew, Atlaw, Daniel, Atout, Maha Moh'd Wahbi, Atreya, Alok, Atteraya, Madhu Sudhan, Aujayeb, Avinash, Ayala Quintanilla, Beatriz Paulina, Ayatollahi, Haleh, Ayyoubzadeh, Seyed Mohammad, Azadnajafabad, Sina, Azevedo, Rui M S, Azzam, Ahmed Y, B, Darshan B, Babaei, Mahsa, Badar, Muhammad, Badiye, Ashish D, Baghcheghi, Nayereh, Baghdadi, Soroush, Bagheri, Nasser, Bagherieh, Sara, Bahrami Asl, Farshad, Bai, Ruhai, Bakshi, Ravleen Kaur, Bam, Kiran, Banach, Maciej, Banke-Thomas, Aduragbemi, Bansal, Hansi, Bantie, Berihun Bantie, Barchitta, Martina, Bardhan, Mainak, Bashiri, Azadeh, Basiru, Afisu, Baskaran, Pritish, Batra, Kavita, Bayani, Mojtaba, Bayleyegn, Nebiyou Simegnew, Bedi, Neeraj, Begum, Tahmina, Behnoush, Amir Hossein, Belgaumi, Uzma Iqbal, Bermudez, Amiel Nazer C, Beyene, Kebede A, Bhandari, Bharti Bhandari, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhattarai, Suraj, Bodolica, Virginia, Braithwaite, Dejana, Brenner, Hermann, Bustanji, Yasser, Butt, Nadeem Shafique, Butt, Zahid A, Cadri, Abdul, Campos-Nonato, Ismael, Cattaruzza, Maria Sofia, Cembranel, Francieli, Cerin, Ester, Chacón-Uscamaita, Pamela Roxana, Charan, Jaykaran, Chattu, Vijay Kumar, Chauhan, Dhun, Chavula, Malizgani Paul, Chen, Simiao, Chi, Gerald, Chitheer, Abdulaal, Cho, William C S, Choudhari, Sonali Gajanan, Chu, Dinh-Toi, Cruz-Martins, Natalia, Dadras, Omid, Dagnew, Gizachew Worku, Dalaba, Maxwell Ayindenaba, Dandona, Lalit, Darwesh, Aso Mohammad, Das, Jai K, Das, Saswati, Dash, Nihar Ranjan, Dávila-Cervantes, Claudio Alberto, Davletov, Kairat, Debela, Berhanu Gidisa, Debele, Aklilu Tamire, Derese, Msganaw, Deribe, Kebede, Dervišević, Emina, Dessie, Anteneh Mengist, Dhali, Arkadeep, Dhulipala, Vishal R, Dirac, M Ashworth, Dong, Wanyue, Dora, Bezabih Terefe, Dsouza, Haneil Larson, Duraes, Andre Rodrigues, Dutta, Sulagna, Dziedzic, Arkadiusz Marian, Ed-Dra, Abdelaziz, Edvardsson, Kristina, Eini, Ebrahim, Ekholuenetale, Michael, El Sayed Zaki, Maysaa, Elgendy, Islam Y, Elhadi, Muhammed, Elshaer, Mohammed, Elsohaby, Ibrahim, Emeto, Theophilus I, Engelbert Bain, Luchuo, Esayas, Hawi Leul, Eshrati, Babak, Esposito, Francesco, Fagbamigbe, Adeniyi Francis, Fakhradiyev, Ildar Ravisovich, Faramarzi, Ali, Faro, Andre, Fatehizadeh, Ali, Fekadu, Ginenus, Fischer, Florian, Fomenkov, Artem Alekseevich, Fukumoto, Takeshi, Gaal, Peter Andras, Gaidhane, Abhay Motiramji, Gajdács, Márió, Galali, Yaseen, Gallus, Silvano, Ganesan, Balasankar, Gazzelloni, Federica, Gebrehiwot, Mesfin, Gebremedhin, Amanuel Tesfay, Gebremeskel, Teferi Gebru, Geda, Yohannes Fikadu, Gezae, Kebede Embaye, Ghazy, Ramy Mohamed, Gheno, Gloria, Gialluisi, Alessandro, Gissler, Mika, Glasbey, James C, Glasstetter, Logan M, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Grivna, Michal, Guha, Avirup, Guicciardi, Stefano, Guo, Hanbing, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Haller, Sebastian, Halwani, Rabih, Hamidi, Samer, Handal, Alexis J, Haro, Josep Maria, Hartman, Nicholas Nathaniel, Hasan, Taufiq, Hasanpour- Dehkordi, Ali, Hasnain, Md Saquib, Hassanipour, Soheil, He, Wen-Qiang, Heidari, Mohammad, Herrera-Serna, Brenda Yuliana, Herteliu, Claudiu, Hessami, Kamran, Hezam, Kamal, Hiraike, Yuta, Holla, Ramesh, Hossain, Md Mahbub, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hu, Chengxi, Huang, Junjie, Huda, M Mamun, Huda, Md Nazmul, Huynh, Hong-Han, Hwang, Bing-Fang, Iftikhar, Pulwasha Maria, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Iranmehr, Arad, Iravanpour, Farideh, Iwagami, Masao, Iwu, Chidozie Declan, Iyasu, Assefa N, Jaafari, Jalil, Jafarzadeh, Abdollah, Jahrami, Haitham, Janodia, Manthan Dilipkumar, Javadi, Nilofer, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jema, Alelign Tasew, Jokar, Mohammad, Joseph, Nitin, Joshua, Charity Ehimwenma, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Karaye, Ibraheem M, Karimi, Hanie, Kasraei, Hengameh, Kauppila, Joonas H, Kendal, Evie Shoshannah, Keykhaei, Mohammad, Khalid, Nauman, Khamesipour, Faham, Khan, M Nuruzzaman, Khan, Maseer, Khan, Yusra H, Khatab, Khaled, Khatatbeh, Haitham, Khatatbeh, Moawiah Mohammad, Khateri, Sorour, Khayat Kashani, Hamid Reza, Khormali, Moein, Kim, Min Seo, Kim, Thanh V, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Kochhar, Sonali, Kolahi, Ali-Asghar, Kompani, Farzad, Koohestani, Hamid Reza, Kosen, Soewarta, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Vijay, Kuate Defo, Barthelemy, Kuchay, Raja Amir Hassan, Kuddus, Mohammed, Kumar, G Anil, Kurmi, Om P, La Vecchia, Carlo, Lacey, Ben, Lahariya, Chandrakant, Laksono, Tri, Lal, Dharmesh Kumar, Lasrado, Savita, Latief, Kamaluddin, Latifinaibin, Kaveh, Le, Thao Thi Thu, Lee, Munjae, Lee, Sang-woong, Lee, Wei-Chen, Lee, Yo Han, Lenzi, Jacopo, Li, Ming-Chieh, Li, Shanshan, Ligade, Virendra S, Lim, Stephen S, Liu, Gang, Liu, Jue, Liu, Xuefeng, Lorenzovici, László, Lotfizadeh, Masoud, M Afifi, Ahmed, Madureira-Carvalho, Áurea M, Magee, Laura A, Majeed, Azeem, Malakan Rad, Elaheh, Malhotra, Kashish, Malik, Ahmad Azam, Malik, Iram, Mallhi, Tauqeer Hussain, Maravilla, Joemer C, Martini, Santi, Martins-Melo, Francisco Rogerlândio Rogerlândio, Martorell, Miquel, Marzan, Melvin Barrientos, Mathangasinghe, Yasith, Mattiello, Rita, Maugeri, Andrea, Mayeli, Mahsa, Mazaheri, Maryam, Mediratta, Rishi P, Mehrabani-Zeinabad, Kamran, Meles, Gebrekiros Gebremichael, Meles, Hadush Negash, Mendez-Lopez, Max Alberto, Mendoza, Walter, Menezes, Ritesh G, Meretoja, Atte, Meretoja, Tuomo J, Michalek, Irmina Maria, Minh, Le Huu Nhat, Mirfakhraie, Reza, Mirghafourvand, Mojgan, Mirica, Andreea, Mirrakhimov, Erkin M, Mirza, Moonis, Mishio Bawa, Eric, Misra, Sanjeev, Mizana, Biru Abdissa, Mohamed, Nouh Saad, Mohammad-Alizadeh-Charandabi, Sakineh, Mohammed, Ghada, Mohammed, Salahuddin, Mohammed, Shafiu, Mokdad, Ali H, Molinaro, Sabrina, Momtazmanesh, Sara, Monasta, Lorenzo, Moni, Mohammad Ali, Moodi Ghalibaf, AmirAli, Moraga, Paula, Morovatdar, Negar, Mosapour, Abbas, Mouodi, Simin, Mousavi, Parsa, Mueller, Ulrich Otto, Mughal, Faraz, Mulita, Admir, Mulita, Francesk, Muriithi, Moses K, Nair, Tapas Sadasivan, Najmuldeen, Hastyar Hama Rashid, Nambi, Gopal, Nangia, Vinay, Nascimento, Gustavo G, Nauman, Javaid, Nejadghaderi, Seyed Aria, Nematollahi, Mohammad Hadi, Nguefack-Tsague, Georges, Ngunjiri, Josephine W, Nguyen, Dang H, Nguyen, Hau Thi Hien, Nguyen, Hien Quang, Nguyen, Phat Tuan, Niazi, Robina Khan, Nikoobar, Ali, Nnyanzi, Lawrence Achilles, Noman, Efaq Ali, Nomura, Shuhei, Noreen, Mamoona, Nurrika, Dieta, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Obamiro, Kehinde O, Ogunsakin, Ropo Ebenezer, Okeke, Sylvester Reuben, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Okwute, Patrick Godwin, Olagunju, Andrew T, Olakunde, Babayemi Oluwaseun, Olatubi, Matthew Idowu, Olufadewa, Isaac Iyinoluwa, Olusanya, Bolajoko Olubukunola, Ordak, Michal, Ortega-Altamirano, Doris V, Osman, Wael M S, Osuagwu, Uchechukwu Levi, Otoiu, Adrian, Otstavnov, Nikita, Otstavnov, Stanislav S, Ouyahia, Amel, Owolabi, Mayowa O, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pana, Adrian, Parija, Pragyan Paramita, Parikh, Romil R, Pashaei, Ava, Patel, Sangram Kishor, Patil, Shankargouda, Pawar, Shrikant, Pedersini, Paolo, Pepito, Veincent Christian Filipino, Peprah, Prince, Pereira, Gavin, Pereira, Jeevan, Pereira, Marcos, Pereira, Maria Odete, Perianayagam, Arokiasamy, Perico, Norberto, Pesudovs, Konrad, Petcu, Ionela-Roxana, Petermann-Rocha, Fanny Emily, Pezeshki, Parmida Sadat, Pham, Tom, Phan, My Kieu, Philip, Anil K, Pigeolet, Manon, Piracha, Zahra Zahid, Podder, Vivek, Poddighe, Dimitri, Pradhan, Pranil Man Singh, Raeisi Shahraki, Hadi, Raghav, Pankaja, Rahman, Mosiur, Rahmanian, Vahid, Raimondo, Ivano, Ramasamy, Shakthi Kumaran, Ranabhat, Chhabi Lal, Rancic, Nemanja, Rao, Chythra R, Rao, Sowmya J, Rasella, Davide, Rashid, Ahmed Mustafa, Rawassizadeh, Reza, Redwan, Elrashdy Moustafa Mohamed, Remuzzi, Giuseppe, Rengasamy, Kannan RR, Renzaho, Andre M N, Rezaei, Nazila, Rezaei, Negar, Rezaeian, Mohsen, Robinson-Oden, Hannah Elizabeth, Roever, Leonardo, Rohloff, Peter, Ronfani, Luca, Rwegerera, Godfrey M, Saad, Aly M A, Saadatian, Zahra, Sabour, Siamak, Saddik, Basema Ahmad, Sadeghi, Malihe, Saeb, Mohammad Reza, Saeed, Umar, Saghazadeh, Amene, Sagoe, Dominic, Saheb Sharif-Askari, Fatemeh, Saheb Sharif-Askari, Narjes, Sahebkar, Amirhossein, Sahoo, Harihar, Sahoo, Soumya Swaroop, Saleh, Mohamed A, Salehi, Sana, Salem, Marwa Rashad, Samy, Abdallah M, Sanjeev, Rama Krishna, Sarikhani, Yaser, Sarode, Sachin C, Satpathy, Maheswar, Sawhney, Monika, Saya, Ganesh Kumar, Saylan, Mete, Schlaich, Markus P, Schneider, Ione Jayce Ceola, Schuermans, Art, Sengupta, Pallav, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serban, Dragos, SeyedAlinaghi, SeyedAhmad, Seylani, Allen, Shafie, Mahan, Shah, Jaffer, Shah, Pritik A, Shahid, Samiah, Shaikh, Masood Ali, Sham, Sunder, Shanawaz, Mohd, Shannawaz, Mohammed, Sharew, Mequannent Melaku, Sharma, Manoj, Shetty, Adithi, Shetty, B Suresh Kumar, Shetty, Pavanchand H, Shiri, Rahman, Shirkoohi, Reza, Shivalli, Siddharudha, Shool, Sina, Shorofi, Seyed Afshin, Shuja, Kanwar Hamza, Shuval, Kerem, Sibhat, Migbar Mekonnen, Sidamo, Negussie Boti, Silva, João Pedro, Simpson, Colin R, Singh, Jasvinder A, Singh, Paramdeep, Singh, Surjit, Skhvitaridze, Natia, Socea, Bogdan, Sohag, Abdullah Al Mamun, Soleimani, Hamidreza, Solomon, Yonatan, Song, Suhang, Song, Yi, Spartalis, Michael, Sreeramareddy, Chandrashekhar T, Stergachis, Andy, Suleman, Muhammad, Sultana, Saima, Sun, Haitong Zhe, Sun, Jing, Szeto, Mindy D, Tabarés-Seisdedos, Rafael, Tabatabai, Shima, Tabish, Mohammad, Taheri, Majid, Taheri Soodejani, Moslem, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tarigan, Ingan Ukur, Tavakoli Oliaee, Razieh, Taye, Birhan Tsegaw, Tefera, Yibekal Manaye, Temsah, Mohamad-Hani, Teramoto, Masayuki, Tesfamariam, Wegen Beyene, Teye-Kwadjo, Enoch, Tharwat, Samar, Thavamani, Aravind, Thomas, Nihal, Titova, Mariya Vladimirovna, Tiyuri, Amir, Topor-Madry, Roman, Tovani-Palone, Marcos Roberto, Tripathy, Jaya Prasad, Tromans, Samuel Joseph, Ubah, Chukwudi S, Umair, Muhammad, Umakanthan, Srikanth, Unim, Brigid, Vaithinathan, Asokan Govindaraj, Valadan Tahbaz, Sahel, Valenti, Mario, Valizadeh, Rohollah, Van den Eynde, Jef, Varthya, Shoban Babu, Veroux, Massimiliano, Verras, Georgios-Ioannis, Villani, Leonardo, Violante, Francesco S, Vlassov, Vasily, Walde, Mandaras Tariku, Wang, Fang, Wang, Shu, Wang, Yanqing, Wang, Yanzhong, Wassie, Emebet Gashaw, Weerakoon, Kosala Gayan, Wolde, Asrat Arja, Xu, Xiaoyue, Yadav, Vikas, Yang, Lin, Yano, Yuichiro, Yehualashet, Sisay Shewasinad, Yi, Siyan, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yonemoto, Naohiro, Zaki, Nazar, Zamagni, Giulia, Zaman, Burhan Abdullah, Zastrozhin, Michael, Zhang, Haijun, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhong, Claire Chenwen, Zielińska, Magdalena, Zuhriyah, Lilik, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher J L, Dandona, Rakhi, and Kassebaum, Nicholas J

Published
2024
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27. CircHTT(2,3,4,5,6) — co-evolving with the HTT CAG-repeat tract — modulates Huntington's disease phenotypes

Author

Morandell, Jasmin, Monziani, Alan, Lazioli, Martina, Donzel, Deborah, Döring, Jessica, Oss Pegorar, Claudio, D’Anzi, Angela, Pellegrini, Miguel, Mattiello, Andrea, Bortolotti, Dalia, Bergonzoni, Guendalina, Tripathi, Takshashila, Mattis, Virginia B., Kovalenko, Marina, Rosati, Jessica, Dieterich, Christoph, Dassi, Erik, Wheeler, Vanessa C., Ellederová, Zdenka, Wilusz, Jeremy E., Viero, Gabriella, and Biagioli, Marta

Published
2024
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29. Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021

Author

Bender, Rose Grace, Sirota, Sarah Brooke, Swetschinski, Lucien R, Dominguez, Regina-Mae Villanueva, Novotney, Amanda, Wool, Eve E, Ikuta, Kevin S, Vongpradith, Avina, Rogowski, Emma Lynn Best, Doxey, Matthew, Troeger, Christopher E, Albertson, Samuel B, Ma, Jianing, He, Jiawei, Maass, Kelsey Lynn, A.F.Simões, Eric, Abdoun, Meriem, Abdul Aziz, Jeza Muhamad, Abdulah, Deldar Morad, Abu Rumeileh, Samir, Abualruz, Hasan, Aburuz, Salahdein, Adepoju, Abiola Victor, Adha, Rishan, Adikusuma, Wirawan, Adra, Saryia, Afraz, Ali, Aghamiri, Shahin, Agodi, Antonella, Ahmadzade, Amir Mahmoud, Ahmed, Haroon, Ahmed, Ayman, Akinosoglou, Karolina, AL-Ahdal, Tareq Mohammed Ali, Al-amer, Rasmieh Mustafa, Albashtawy, Mohammed, AlBataineh, Mohammad T., Alemi, Hediyeh, Al-Gheethi, Adel Ali Saeed, Ali, Abid, Ali, Syed Shujait Shujait, Alqahtani, Jaber S, AlQudah, Mohammad, Al-Tawfiq, Jaffar A., Al-Worafi, Yaser Mohammed, Alzoubi, Karem H, Amani, Reza, Amegbor, Prince M, Ameyaw, Edward Kwabena, Amuasi, John H, Anil, Abhishek, Anyanwu, Philip Emeka, Arafat, Mosab, Areda, Damelash, Arefnezhad, Reza, Atalell, Kendalem Asmare, Ayele, Firayad, Azzam, Ahmed Y, Babamohamadi, Hassan, Babin, François-Xavier, Bahurupi, Yogesh, Baker, Stephen, Banik, Biswajit, Barchitta, Martina, Barqawi, Hiba Jawdat, Basharat, Zarrin, Baskaran, Pritish, Batra, Kavita, Batra, Ravi, Bayileyegn, Nebiyou Simegnew, Beloukas, Apostolos, Berkley, James A, Beyene, Kebede A, Bhargava, Ashish, Bhattacharjee, Priyadarshini, Bielicki, Julia A, Bilalaga, Mariah Malak, Bitra, Veera R, Brown, Colin Stewart, Burkart, Katrin, Bustanji, Yasser, Carr, Sinclair, Chahine, Yaacoub, Chattu, Vijay Kumar, Chichagi, Fatemeh, Chopra, Hitesh, Chukwu, Isaac Sunday, Chung, Eunice, Dadana, Sriharsha, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Darban, Isaac, Dash, Nihar Ranjan, Dashti, Mohsen, Dashtkoohi, Mohadese, Dekker, Denise Myriam, Delgado-Enciso, Ivan, Devanbu, Vinoth Gnana Chellaiyan, Dhama, Kuldeep, Diao, Nancy, Do, Thao Huynh Phuong, Dokova, Klara Georgieva, Dolecek, Christiane, Dziedzic, Arkadiusz Marian, Eckmanns, Tim, Ed-Dra, Abdelaziz, Efendi, Ferry, Eftekharimehrabad, Aziz, Eyre, David William, Fahim, Ayesha, Feizkhah, Alireza, Felton, Timothy William, Ferreira, Nuno, Flor, Luisa S, Gaihre, Santosh, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Geffers, Christine, Gerema, Urge, Ghaffari, Kazem, Goldust, Mohamad, Goleij, Pouya, Guan, Shi-Yang, Gudeta, Mesay Dechasa, Guo, Cui, Gupta, Veer Bala, Gupta, Ishita, Habibzadeh, Farrokh, Hadi, Najah R, Haeuser, Emily, Hailu, Wase Benti, Hajibeygi, Ramtin, Haj-Mirzaian, Arvin, Haller, Sebastian, Hamiduzzaman, Mohammad, Hanifi, Nasrin, Hansel, Jan, Hasnain, Md Saquib, Haubold, Johannes, Hoan, Nguyen Quoc, Huynh, Hong-Han, Iregbu, Kenneth Chukwuemeka, Islam, Md. Rabiul, Jafarzadeh, Abdollah, Jairoun, Ammar Abdulrahman, Jalili, Mahsa, Jomehzadeh, Nabi, Joshua, Charity Ehimwenma, Kabir, Md. Awal, Kamal, Zul, Kanmodi, Kehinde Kazeem, Kantar, Rami S., Karimi Behnagh, Arman, Kaur, Navjot, Kaur, Harkiran, Khamesipour, Faham, Khan, M Nuruzzaman, Khan suheb, Mahammed Ziauddin, Khanal, Vishnu, Khatab, Khaled, Khatib, Mahalaqua Nazli, Kim, Grace, Kim, Kwanghyun, Kitila, Aiggan Tamene Tamene, Komaki, Somayeh, Krishan, Kewal, Krumkamp, Ralf, Kuddus, Md Abdul, Kurniasari, Maria Dyah, Lahariya, Chandrakant, Latifinaibin, Kaveh, Le, Nhi Huu Hanh, Le, Thao Thi Thu, Le, Trang Diep Thanh, Lee, Seung Won, LEPAPE, Alain, Lerango, Temesgen L., Li, Ming-Chieh, Mahboobipour, Amir Ali, Malhotra, Kashish, Mallhi, Tauqeer Hussain, Manoharan, Anand, Martinez-Guerra, Bernardo Alfonso, Mathioudakis, Alexander G., Mattiello, Rita, May, Jürgen, McManigal, Barney, McPhail, Steven M, Mekene Meto, Tesfahun, Mendez-Lopez, Max Alberto Mendez, Meo, Sultan Ayoub, Merati, Mohsen, Mestrovic, Tomislav, Mhlanga, Laurette, Minh, Le Huu Nhat, Misganaw, Awoke, Mishra, Vinaytosh, Misra, Arup Kumar, Mohamed, Nouh Saad, Mohammadi, Esmaeil, Mohammed, Mesud, Mohammed, Mustapha, Mokdad, Ali H, Monasta, Lorenzo, Moore, Catrin E, Motappa, Rohith, Mougin, Vincent, Mousavi, Parsa, Mulita, Francesk, Mulu, Atsedemariam Andualem, Naghavi, Pirouz, Naik, Ganesh R, Nainu, Firzan, Nair, Tapas Sadasivan, Nargus, Shumaila, Negaresh, Mohammad, Nguyen, Hau Thi Hien, Nguyen, Dang H, Nguyen, Van Thanh, Nikolouzakis, Taxiarchis Konstantinos, Noman, Efaq Ali, Nri-Ezedi, Chisom Adaobi, Odetokun, Ismail A., Okwute, Patrick Godwin, Olana, Matifan Dereje, Olanipekun, Titilope O, Olasupo, Omotola O., Olivas-Martinez, Antonio, Ordak, Michal, Ortiz-Brizuela, Edgar, Ouyahia, Amel, Padubidri, Jagadish Rao, Pak, Anton, Pandey, Anamika, Pantazopoulos, Ioannis, Parija, Pragyan Paramita, Parikh, Romil R, Park, Seoyeon, Parthasarathi, Ashwaghosha, Pashaei, Ava, Peprah, Prince, Pham, Hoang Tran, Poddighe, Dimitri, Pollard, Andrew, Ponce-De-Leon, Alfredo, Prakash, Peralam Yegneswaran, Prates, Elton Junio Sady, Quan, Nguyen Khoi, Raee, Pourya, Rahim, Fakher, Rahman, Mosiur, Rahmati, Masoud, Ramasamy, Shakthi Kumaran, Ranjan, Shubham, Rao, Indu Ramachandra, Rashid, Ahmed Mustafa, Rattanavong, Sayaphet, Ravikumar, Nakul, Reddy, Murali Mohan Rama Krishna, Redwan, Elrashdy Moustafa Mohamed, Reiner, Robert C, Jr., Reyes, Luis Felipe, Roberts, Tamalee, Rodrigues, Mónica, Rosenthal, Victor Daniel, Roy, Priyanka, Runghien, Tilleye, Saeed, Umar, Saghazadeh, Amene, Saheb Sharif-Askari, Narjes, Saheb Sharif-Askari, Fatemeh, Sahoo, Soumya Swaroop, Sahu, Monalisha, Sakshaug, Joseph W, Salami, Afeez Abolarinwa, Saleh, Mohamed A., Salehi omran, Hossein, Sallam, Malik, Samadzadeh, Sara, Samodra, Yoseph Leonardo, Sanjeev, Rama Krishna, Sarasmita, Made Ary, Saravanan, Aswini, Sartorius, Benn, Saulam, Jennifer, Schumacher, Austin E, Seyedi, Seyed Arsalan, Shafie, Mahan, Shahid, Samiah, Sham, Sunder, Shamim, Muhammad Aaqib, Shamshirgaran, Mohammad Ali, Shastry, Rajesh P., Sherchan, Samendra P, Shiferaw, Desalegn, Shittu, Aminu, Siddig, Emmanuel Edwar, Sinto, Robert, Sood, Aayushi, Sorensen, Reed J D, Stergachis, Andy, Stoeva, Temenuga Zhekova, Swain, Chandan Kumar, Szarpak, Lukasz, Tamuzi, Jacques Lukenze, Temsah, Mohamad-Hani, Tessema, Melkamu B Tessema, Thangaraju, Pugazhenthan, Tran, Nghia Minh, Tran, Ngoc-Ha, Tumurkhuu, Munkhtuya, Ty, Sree Sudha, Udoakang, Aniefiok John, Ulhaq, Inam, Umar, Tungki Pratama, Umer, Abdurezak Adem, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Van den Eynde, Jef, Walson, Judd L, Waqas, Muhammad, Xing, Yuhan, Yadav, Mukesh Kumar, Yahya, Galal, Yon, Dong Keon, Zahedi Bialvaei, Abed, Zakham, Fathiah, Zeleke, Abyalew Mamuye, Zhai, Chunxia, Zhang, Zhaofeng, Zhang, Haijun, Zielińska, Magdalena, Zheng, Peng, Aravkin, Aleksandr Y, Vos, Theo, Hay, Simon I, Mosser, Jonathan F., Lim, Stephen S, Naghavi, Mohsen, Murray, Christopher J L, and Kyu, Hmwe Hmwe

Published
2024
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30. Quality of life assessment instruments in children and adolescents with neuromuscular diseases: a systematic scoping review

Author

Karoliny Lisandra Teixeira Cruz, Isadora Cristina Sousa Santos, Cyntia Rogean de Jesus Alves de Baptista, and Ana Claudia Mattiello-Sverzut

Subjects
HRQOL, Health-related quality of life, Neuromuscular disease, Children, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Objective (1) To identify instruments used to assess quality of life (QoL) in children and adolescents with neuromuscular diseases; (2) To identify the psychometric properties contained in these instruments. Methods This is a scoping review in which the electronic databases Embase, Scielo, Scopus, Pubmed and Lilacs were used as well as grey literature. The following terms were used in the search for articles published in the last 10 years: children, adolescents, neuromuscular disease, and quality of life. Results In total, 15 articles were included and evaluated, indicating 7 instruments used to assess QoL (PedsQL™ Inventory 3.0 Neuromuscular Module, the PedsQL™ 4.0, the PedsQL DMD Module, the PedsQL ™ MFS, the SOLE, the KIDSCREEN and the LSI-A). The number of items ranged from 17 to 45. In addition, 6 instruments showed psychometric properties, but only 2 showed good and high quality, either in internal reliability or reproducibility. Conclusion Our results were able to map the main QoL assessment instruments of children and adolescents with neuromuscular disease and the most cited instrument was the PedsQL™ Inventory 3.0 Neuromuscular Module. Larger studies that assess psychometric properties and that are validated for most diseases are needed.

Published
2024
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32. Comparative Studies on Nanocellulose as a Bio-Based Consolidating Agent for Ancient Wood

Author

Anastasia Fornari, Daniele Rocco, Leonardo Mattiello, Martina Bortolami, Marco Rossi, Laura Bergamonti, Claudia Graiff, Stefania Bani, Fabio Morresi, and Fabiana Pandolfi

Subjects
nanocellulose, cultural heritage, ancient wood, consolidation, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

In this work, nanocellulose aqueous dispersions were studied as a bio-inspired consolidating agent for the recovery and conservation of ancient wood and compared with two of the most used traditional consolidants: the synthetic resins Paraloid B-72 and Regalrez 1126. The morphology of crystalline nanocellulose (CNC), determined using Scanning Electron Microscopy (SEM), presents with a rod-like shape, with a size ranging between 15 and 30 nm in width. Chemical characterization performed using the Fourier-Transform Infrared Spectroscopy (FT-IR) technique provides information on surface modifications, in this case, demonstrating the presence of only the characteristic peaks of nanocellulose. Moreover, conductometric, pH, and dry matter measurements were carried out, showing also in this case values perfectly conforming to what is found in the literature. The treated wood samples were observed under an optical microscope in reflected light and under a scanning electron microscope to determine, respectively, the damage caused by xylophages and the morphology of the treated surfaces. The images acquired show the greater similarity of the surfaces treated with nanocellulose to untreated wood, compared with other consolidating agents. Finally, a colorimetric analysis of these samples was also carried out before and after a first consolidation treatment, and after a second treatment carried out on the same samples three years later. The samples treated with CNC appeared very homogeneous and uniform, without alterations in their final color appearance, compared to other traditional synthetic products.

Published
2024
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38. Physics for the masses: teaching Einsteinian gravity in primary school

Author

Ruggiero, Matteo Luca, Mattiello, Sara, and Leone, Matteo

Subjects
Physics - Physics Education, General Relativity and Quantum Cosmology
Abstract

Why is modern physics still today, more than 100 years after its birth, the privilege of an elite of scientists and unknown for the great majority of citizens? The answer is simple, since modern physics is in general not present in the standard physics curricula, except for some general outlines, in the final years of some secondary schools. But, is it possibile to teach modern physics in primary school? Is it effective? And, also, is it engaging for students? These are the simple questions which stimulated our research, based on an intervention performed in the last year of Italian primary school, focused on teaching gravity, according to the Einsteinian approach in the spirit of the Einstein First project, an international collaboration which aims to teach school age children the concepts of modern physics. The outcomes of our research study are in agreement with previous findings obtained in Australian schools, thus they contribute to validate them and show that there is no cultural effect, since the approach works in different education systems. Finally, our results are relevant also in terms of retention and prove that the students involved really understand the key ideas., Comment: 9 pages, 8 figures

Published
2021
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41. A methodological approach to compare continuous and instantaneous sampling and two methods to deal with animals out of sight on dairy cattle behavior and interaction with their calf in the first hours post-partum

Author

Claudia Manfrè, Monica Battini, Alberto Simonetto, Barbara Contiero, Lorenzo Serva, Silvana Mattiello, Stavros Ntalampiras, Simona Normando, and Marta Brscic

Subjects
animal welfare, dairy cattle, dam-calf bond, maternal behavior, social cognition, vocalization, Veterinary medicine, SF600-1100
Abstract

Animal behavior can provide useful information about animal welfare, but methods and tools used to gather behavioral data and data treatment can influence the results. Therefore, this study was carried out on dairy cow (Bos taurus) behavior and interaction with calves early post-partum aiming at comparing two sampling rules, namely continuous and instantaneous sampling at scan intervals of 30 s, 1, 2, 3, 4, 5, and 10 min, and of two methods to deal with out of sight animals. The study was based on three assumptions: (1) continuous sampling provides the most complete and accurate data, allowing the observation of seldom behaviors and short events; (2) instantaneous sampling can provide accurate measurements of frequency and duration, especially at short scan intervals; (3) differences in behavioral results may occur depending on whether a correction for time out of sight is applied or not. Thus, 10 dams were observed from videos in the 2 h post-parturition. Ruminating, stereotypies, calf-biting and calf-butting were not recorded during the observation period. Other behaviors were observed only with continuous sampling or with continuous and instantaneous at 30-s scan intervals. The recoding of several behaviors was less accurate when applying longer scan intervals. Data from continuous and instantaneous sampling at 30-s scan intervals were compared with Wilcoxon test. Results showed no significant differences for posture, position in the pen and all behaviors (p > 0.05) except vocalizing (p = 0.003). The same test did not highlight significant differences due to method of dealing with out of sight for both sampling rules (p > 0.05). Correlation between continuous and instantaneous sampling were prevalently high at 30-s intervals and they decreased as the length of scan intervals increased for most behaviors. Results confirmed the first two assumptions suggesting that continuous sampling is more accurate, in particular for short and rare behaviors, and caution against the suitability of dam behavioral data collected using instantaneous sampling at scan intervals of minutes. The third assumption was not proven by this study. Results should be considered in light of the development of new technologies that relies on data acquired by sensors and imaging to monitor cow-calf welfare and behavior post-parturition.

Published
2024
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42. Identification of a microbial sub-community from the feral chicken gut that reduces Salmonella colonization and improves gut health in a gnotobiotic chicken model

Author

Supapit Wongkuna, Achuthan Ambat, Sudeep Ghimire, Samara Paula Mattiello, Abhijit Maji, Roshan Kumar, Linto Antony, Surang Chankhamhaengdecha, Tavan Janvilisri, Eric Nelson, Kinchel C. Doerner, Sunil More, Melissa Behr, and Joy Scaria

Subjects
Salmonella, gut microbiome, chicken, colonization resistance, culturomics, germ-free, Microbiology, QR1-502
Abstract

ABSTRACTA complex microbial community in the gut may prevent the colonization of enteric pathogens such as Salmonella. Some individual or a combination of species in the gut may confer colonization resistance against Salmonella. To gain a better understanding of the colonization resistance against Salmonella enterica, we isolated a library of 1,300 bacterial strains from feral chicken gut microbiota which represented a total of 51 species. Using a co-culture assay, we screened the representative species from this library and identified 30 species that inhibited Salmonella enterica subspecies enterica serovar Typhimurium in vitro. To improve the Salmonella inhibition capacity, from a pool of fast-growing species, we formulated 66 bacterial blends, each of which composed of 10 species. Bacterial blends were more efficient in inhibiting Salmonella as compared to individual species. The blend that showed maximum inhibition (Mix10) also inhibited other serotypes of Salmonella frequently found in poultry. The in vivo effect of Mix10 was examined in a gnotobiotic and conventional chicken model. The Mix10 consortium significantly reduced Salmonella load at day 2 post-infection in gnotobiotic chicken model and decreased intestinal tissue damage and inflammation in both models. Cell-free supernatant of Mix10 did not show Salmonella inhibition, indicating that Mix10 inhibits Salmonella through either nutritional competition, competitive exclusion, or through reinforcement of host immunity. Out of 10 species, 3 species in Mix10 did not colonize, while 3 species constituted more than 70% of the community. Two of these species were previously uncultured bacteria. Our approach could be used as a high-throughput screening system to identify additional bacterial sub-communities that confer colonization resistance against enteric pathogens and its effect on the host.IMPORTANCESalmonella colonization in chicken and human infections originating from Salmonella-contaminated poultry is a significant problem. Poultry has been identified as the most common food linked to enteric pathogen outbreaks in the United States. Since multi-drug-resistant Salmonella often colonize chicken and cause human infections, methods to control Salmonella colonization in poultry are needed. The method we describe here could form the basis of developing gut microbiota-derived bacterial blends as a microbial ecosystem therapeutic against Salmonella.

Published
2024
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43. A comparison of the prognostic performance of the Lugano 2014 and RECIL 2017 response criteria in patients with NHL from the phase III GOYA and GALLIUM trials

Author

Lale Kostakoglu, Maurizio Martelli, Laurie H. Sehn, Andrew Davies, Marek Trněný, Michael Herold, Umberto Vitolo, Wolfgang Hiddemann, Judith Trotman, Andrea Knapp, Federico Mattiello, Tina G. Nielsen, Deniz Sahin, Gila Sellam, Carol Ward, and Anas Younes

Subjects
GALLIUM, GOYA, Lugano 2014, NHL, RECIL 2017, response criteria, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Abstract The Lugano 2014 criteria are the standard for response assessment in lymphoma. We compared the prognostic performance of Lugano 2014 and the more recently developed response evaluation criteria in lymphoma (RECIL 2017), which relies primarily on computed tomography and uses unidimensional measurements, in patients with previously untreated diffuse large B‐cell lymphoma (DLBCL) and follicular lymphoma (FL) from the phase III GOYA and GALLIUM trials, respectively. Concordance between responses according to the Lugano 2014 and RECIL 2017 criteria was analyzed. Landmark analyses of progression‐free survival (PFS) and overall survival (OS) by end of treatment (EOT) and end of induction (EOI) response status according to RECIL 2017 and Lugano 2014 criteria, and prognostic value of response at EOT/EOI were also compared. Overall, 1333 patients were included from GOYA and 502 from GALLIUM. Complete response (CR) status according to RECIL 2017 criteria showed high concordance with complete metabolic response (CMR) status by Lugano 2014 criteria in both GOYA (92.5%) and GALLIUM (92.4%). EOT and EOI CR/CMR status by both criteria was highly prognostic for PFS in GOYA (RECIL 2017 [CR]: hazard ratio [HR], 0.35 [95% confidence interval [CI] 0.26–0.46]; Lugano 2014 [CMR]: HR, 0.35 [95% CI 0.26–0.48]; both p

Published
2023
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44. Fluoroquinolone and beta-lactam antimicrobials induce different transcriptome profiles in Salmonella enterica persister cells

Author

S. P. Mattiello, V. C. Barth, J. Scaria, C. A. S. Ferreira, and S. D. Oliveira

Subjects
Medicine, Science
Abstract

Abstract Here, we investigate the transcriptome profiles of two S. Enteritidis and one S. Schwarzengrund isolates that present different persister levels when exposed to ciprofloxacin or ceftazidime. It was possible to note a distinct transcript profile among isolates, time of exposure, and treatment. We could not find a commonly expressed transcript profile that plays a role in persister formation after S. enterica exposure to beta-lactam or fluoroquinolone, as only three DEGs presented the same behavior under the conditions and isolates tested. It appears that the formation of persisters in S. enterica after exposure to ciprofloxacin is linked to the overexpression of genes involved in the SOS response (recA), cell division inhibitor (sulA), iron-sulfur metabolism (hscA and iscS), and type I TA system (tisB). On the other hand, most genes differentially expressed in S. enterica after exposure to ceftazidime appeared to be downregulated and were part of the flagellar assembly apparatus, citrate cycle (TCA cycle), glycolysis/gluconeogenesis, carbon metabolism, bacterial secretion system, quorum sensing, pyruvate metabolism pathway, and biosynthesis of secondary metabolites. The different transcriptome profiles found in S. enterica persisters induced by ciprofloxacin and ceftazidime suggest that these cells modulate their response differently according to each stress.

Published
2023
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47. Modelling a CubeSat-based Space Mission and its Operation

Author

Batista, Carlos Leandro Gomes and Mattiello-Francisco, Fátima

Subjects
Computer Science - Software Engineering
Abstract

Since the early 2000' years, the CubeSats have been growing and getting more and more "space" in the Space industry. Their short development schedule, low cost equipment and piggyback launches create a new way to access the space, provide new services and enable the development of new technologies for processes and applications. That is the case of the Verification and Validation of these missions. As they are cheaper to launch than traditional space missions, CubeSats win by numbers. With more than 1000 CubeSats launched they still achieve less than 50% rate of successful missions and that is caused mainly by poor V&V processes. Model Based approaches are trying to help in these problems as they help software developers along the last years. As complex systems, space products can be helped by the introduction of models in different levels. Operational goals can be achieved by modeling behavioral scenarios and simulating operational procedures. Here, we present a possible modeling solution using a tool that integrates the functionalities of FSM and Statechartes, the ATOM SysVAP (System for Validation of Finite Automatons and Execution Plans). With this tool we are able to model the behaviour of a space mission, from its top level (i.e. system and segments) to its low level (subsystems) and simulate their interactions (operation). With the help of Lua Programming Language, it is possible to generate analysis files, specific scenarios and control internal variables., Comment: 4 pages, 28th Minisymposium of the Department of Measurement and Information Systems Budapest University of Technology and Economics

Published
2021

48. Using Fault Injection on the Nanosatellite Subsystems Integration Testing

Author

Batista, Carlos Leandro Gomes, Corsetti, André, and Mattiello-Francisco, Fátima

Subjects
Computer Science - Other Computer Science
Abstract

Since the 2000's, an increased number of nanosatellites have accessed space. However, studies show that the number of unsuccessful nanosatellite missions is very expressive. Moreover, these statistics are correlated to poor verification and validation processes used by hobbyists satellite developers because major space agencies keep high successful ratings even with small/nano satellites missions due to its rigorous V\&V processes. Aiming to improve payloads integration testing of NanosatC-BR-2, a 2-U Cubesat based nanosatellite under development by INPE, the fault injection technique has been used. It is very useful technique to test systems prototypes. We present the design and implementation of a Failure Emulator Mechanism (FEM) on I2C communication bus for testing the interaction among the NCBR2 subsystems, supporting interoperability and robustness requirements verification. The FEM is modelled to work at the communication bus emulating eventual faults of the communicating subsystems in the messages exchanged. Using an Arduino board for the FEM and NI LabView environment it is possible to program the mechanism to inject different faults at the I2C bus during different operation modes. Based on a serial architecture, the FEM will be able to intercept all messages and implement different faults as service and timing faults. The FEM interface with the tester is designed in LabView environment. Control and observation facilities are available to generate and upload the faultload script to FEM Arduino board. The proposed FEM architecture and its implementation are validated using two subsystems under testing prototypes: the OnBoard Data Handling Computer and the Langmuir Probe NCBR2 payload. For this analysis purpose, the prototypes simulate in two different Arduinos boards the expected behavior of each subsystem in the communication., Comment: 8 pages, 8 figures, 1st IAA Latin American Symposium on Small Satellites

Published
2021

49. Pickup concepts for ultra-low charged short bunches in X-Ray Free-Electron Lasers

Author

Scheible, Bernhard E. J., Mattiello, Stefano, Czwalinna, Marie K., Schlarb, Holger, Ackermann, Wolfgang, De Gersem, Herbert, and Penirschke, Andreas

Subjects
Physics - Instrumentation and Detectors, Physics - Accelerator Physics
Abstract

The all-optical synchronization systems used in various X-ray free-electron lasers (XFEL) such as the European XFEL observe the transient fields of passing electron bunches coupled into one or more pickups in the Bunch Arrival Time Monitors (BAM). The extracted signal is then amplitude modulated on reference laser pulses in a Mach-Zehnder type electro-optical modulator. With the emerging demand for future experiments with ultra-short FEL shots, fs precision is required for the synchronization systems even with 1 pC bunches. Since the sensitivity of the BAM depends in particular on the slope of the bipolar signal at the zero-crossing and thus, also on the bunch charge, a redesign with the aim of a significant increase by optimized geometry and bandwidth is inevitable. In this contribution the theoretical foundations of the pickup signal are aggregated and treated with a focus on ultra-short bunches as well as a general formulation. A possible new pickup concept is simulated and its performance is compared to the previous concept. A significant improvement of slope and voltage is found. The improvement is mainly achieved by the reduced distance to the beam and a higher bandwidth., Comment: 14 pages, 18 figures. This contribution will be submitted to the Physical Review Accelerators and Beams (PRAB) for the Special Edition on the 9th International Beam Instrumentation Conference, IBIC 2020

Published
2021
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50. Hydrogen Production from Sugarcane Bagasse Pentose Liquor Fermentation Using Different Food/Microorganism and Carbon/Nitrogen Ratios under Mesophilic and Thermophilic Conditions

Author

Luísa Mattiello-Francisco, Filipe Vasconcelos Ferreira, Guilherme Peixoto, Gustavo Mockaitis, and Marcelo Zaiat

Subjects
hydrogen, pentose liquor, xylose, sugarcane bagasse, batch reactors, mesophilic condition, Fermentation industries. Beverages. Alcohol, TP500-660
Abstract

Hydrogen is a well-known clean energy carrier with a high energetic yield. Its versatility allows it to be produced in diverse ways, including biologically. Specifically, dark fermentation takes advantage of organic wastes, such as agro-industrial residues, to obtain hydrogen. One of these harmful wastes that is poorly discharged into streams is sugarcane bagasse pentose liquor (SBPL). The present study aimed to investigate hydrogen generation from SBPL fermentation in batch reactors by applying different food/microorganism (2–10 F/M) and carbon/nitrogen (10–200 C/N) ratios under mesophilic and thermophilic conditions. Biohydrogen was produced in all pentose liquor experiments along with other soluble microbial products (SMPs): volatile fatty acids (VFAs) (at least 1.38 g L−1 and 1.84 g L−1 by the average of C/N and F/M conditions, respectively) and alcohols (at least 0.67 g L−1 and 0.325 g L−1 by the average of C/N and F/M conditions, respectively). Thermophilic pentose liquor reactors (t-PLRs) showed the highest H2 production (H2 maximum: 1.9 ± 0.06 L in 100 C/N) and hydrogen yield (HY) (1.9 ± 0.54 moles of H2 moles of substrate−1 in 2 F/M) when compared to mesophilic ones (m-PLRs). The main VFA produced was acetate (>0.85 g L−1, considering the average of both nutritional conditions), especially through the butyrate pathway, which was the most common metabolic route of experimental essays. Considering the level of acid dilution used in the pretreatment of bagasse (H2SO4 (1%), 1.1 atm, 120 °C, 60 min), it is unlikely that toxic compounds such as furan derivatives, phenol-like substances (neither was measured), and acetate (−1) hinder the H2 production in the pentose liquor reactors (PLRs). Sugarcane bagasse pentose liquor fermentation may become a suitable gateway to convert a highly polluting waste into a renewable feedstock through valuable hydrogen production.

Published
2024
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