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8 results on '"Mattia Maramai"'

1. Neoadjuvant Chemotherapy Followed by Radical Surgery versus Concurrent Chemo-Radiotherapy in the Treatment of Locally Advanced Cervical Cancer: A Multicenter Retrospective Analysis

Author

Paolo Sala, Stefano Bogliolo, Fabio Barra, Alessandra Fazio, Mattia Maramai, Chiara Cassani, Barbara Gardella, Luciana Babilonti, Flavio Giannelli, Serafina Mammoliti, Arsenio Spinillo, Simone Ferrero, Mario Valenzano Menada, Sergio Costantini, Paolo Bruzzi, and Pierangelo Marchiolè

Subjects
cancer, cervical cancer, disease-free survival, overall survival, locally advanced cervical cancer, radical surgery, chemo-radiotherapy, treatment choice, Surgery, RD1-811
Abstract

Objectives This study aims to evaluate oncological outcomes in women affected by locally advanced cervical cancer (LACC) treated by neoadjuvant chemotherapy before radical surgery (NACT + RS) or concurrent chemo-radiotherapy (CCRT). Methods This was a multicenter retrospective analysis of data related to women with LACC (FIGO stage IB2-IVA), who were treated by NACT + RS or CCRT between November 2006 and January 2018. The first endpoints were the evaluation of disease-free survival (DFS) and overall survival (OS); univariate and multivariate analyses were performed for identifying the prognostic factors independently associated with these oncological outcomes. Results Overall, 106 women were included in the analysis; 55 of them (51.9%) underwent NACT + RS and 51 (48.1%) CCRT, respectively. Patients in the NACT + RS group had a significant better five-year DFS and five-year OS than those in the CCRT group (77.4% vs. 33.4%, p

Published
2022
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3. Endometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target

Author

Fabio Barra, Lorenzo Ferro Desideri, Umberto Leone Roberti Maggiore, Valerio Gaetano Vellone, Mattia Maramai, Carolina Scala, and Simone Ferrero

Subjects
endometriosis, genetic polymorphisms, tumor necrosis factor, alpha, Medicine (General), R5-920
Abstract

In the recent original research published on International Journal of Fertility and Sterility the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and endometriosis in 150 Iranian patients suffered this disease. The authors notably found a lower frequency of TNF-α -863C/A allele A among the affected patients in comparison with healthy women, although this difference was not significant by adjusting multiple testing. We deem that the authors should specify, if these patients had peritoneal nodules, ovarian endometrioma/deep infiltrating endometriosis (DIE) nodules or combination of them, since it has been hypothesized that these phenotypes may represent three distinct pathogenetic entities of endometriosis.

Published
2020
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4. Mucinous ovarian cancer: current therapeutic targets, preclinical progress, and experimental drugs

Author

Fabio Barra, Mattia Maramai, Simone Ferrero, Melita Moioli, Mario Valenzano Menada, Valerio Gaetano Vellone, and Sergio Costantini

Subjects
0301 basic medicine, endocrine system diseases, medicine.medical_treatment, Drug Evaluation, Preclinical, Antineoplastic Agents, Carcinoma, Ovarian Epithelial, medicine.disease_cause, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, Drug Development, medicine, Animals, Humans, Pharmacology (medical), Epithelial ovarian cancer, Molecular Targeted Therapy, Cause of death, Ovarian Neoplasms, Pharmacology, business.industry, General Medicine, medicine.disease, Adenocarcinoma, Mucinous, female genital diseases and pregnancy complications, Serous fluid, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Female, KRAS, Ovarian cancer, business, Clear cell
Abstract

Among gynecologic malignancies, epithelial ovarian cancer (EOC) is the second most common type and the leading cause of death. The main subtypes (serous, mucinous, endometrioid and clear cell carci...

Published
2019

5. Neoadjuvant Chemotherapy Followed by Radical Surgery versus Concurrent Chemo-Radiotherapy in the Treatment of Locally Advanced Cervical Cancer: A Multicenter Retrospective Analysis

Author

Chiara Cassani, Stefano Bogliolo, Luciana Babilonti, Flavio Giannelli, Simone Ferrero, Barbara Gardella, Paolo Bruzzi, S. Mammoliti, Arsenio Spinillo, Alessandra Fazio, Mattia Maramai, Mario Valenzano Menada, Sergio Costantini, Fabio Barra, Pierangelo Marchiolè, and Paolo Sala

Subjects
Oncology, medicine.medical_specialty, disease-free survival, cervical cancer, medicine.medical_treatment, overall survival, Locally advanced, radical surgery, Uterine Cervical Neoplasms, Cancer, chemo-radiotherapy, locally advanced cervical cancer, treatment choice, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Overall survival, Retrospective analysis, Medicine, Humans, Radical surgery, Neoplasm Staging, Retrospective Studies, Cervical cancer, Chemo-radiotherapy, Chemotherapy, business.industry, Chemoradiotherapy, medicine.disease, Neoadjuvant Therapy, Treatment Outcome, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, Female, business
Abstract

This study aims to evaluate oncological outcomes in women affected by locally advanced cervical cancer (LACC) treated by neoadjuvant chemotherapy before radical surgery (NACT + RS) or concurrent chemo-radiotherapy (CCRT).This was a multicenter retrospective analysis of data related to women with LACC (FIGO stage IB2-IVA), who were treated by NACT + RS or CCRT between November 2006 and January 2018. The first endpoints were the evaluation of disease-free survival (DFS) and overall survival (OS); univariate and multivariate analyses were performed for identifying the prognostic factors independently associated with these oncological outcomes.Overall, 106 women were included in the analysis; 55 of them (51.9%) underwent NACT + RS and 51 (48.1%) CCRT, respectively. Patients in the NACT + RS group had a significant better five-year DFS and five-year OS than those in the CCRT group (77.4% vs. 33.4%,This retrospective study demonstrated an improved survival outcome for patients undergoing NACT + RS compared with those undergoing CCRT. Our findings seem to support the use of NACT before RS as an effective alternative option to CCRT standard therapy.

Published
2020

6. Borderline ovarian tumours: Management in the era of fertility-sparing surgery

Author

Sara Stigliani, Fabio Barra, Mattia Maramai, Sergio Costantini, Simone Ferrero, Melita Moioli, and Mario Valenzano Menada

Subjects
Oncology, Cancer Research, medicine.medical_specialty, media_common.quotation_subject, Salpingo-oophorectomy, Fertility, Review, Ovarian neoplasms, Fertility sparing surgery, Stromal Invasion, 03 medical and health sciences, 0302 clinical medicine, Ovarian cysts, Internal medicine, medicine, Epithelial proliferation, Fertility preservation, Nuclear atypia, Ovarian tumours, media_common, 030219 obstetrics & reproductive medicine, integumentary system, business.industry, 030220 oncology & carcinogenesis, business
Abstract

Borderline ovarian tumours (BOTs) are ovarian neoplasms characterised by epithelial proliferation, variable nuclear atypia and no evidence of destructive stromal invasion. BOTs account for approximately 15% of all epithelial ovarian cancers. Due to the fact that the majority of BOTs occur in women under 40 years of age, their surgical management often has to consider fertility-sparing approaches. The aim of this mini-review is to discuss the state of the art of fertility-sparing surgery for BOTs with a specific focus on the extent of surgery, post-operative management and fertility.

Published
2020

7. Feasibility of Cardiophrenic Lymphadenectomy During Interval Debulking Surgery for Advanced Ovarian Cancer: Early Evidence from Preliminary Data

Author

Giulio Evangelisti, Mattia Maramai, Fabio Barra, Simone Ferrero, Melita Moioli, and Sergio Costantini

Subjects
Ovarian Neoplasms, medicine.medical_specialty, Advanced ovarian cancer, business.industry, medicine.medical_treatment, Cytoreduction Surgical Procedures, Debulking, Surgery, Medicine, Interval (graph theory), Feasibility Studies, Humans, Lymph Node Excision, Lymphadenectomy, Female, business, Preliminary Data
Published
2019

8. Robotic sentinel lymph node detection using indocyanine green

Author

Maria Teresa Achilarre, Vanna Zanagnolo, and Mattia Maramai

Subjects
medicine.medical_specialty, chemistry.chemical_compound, chemistry, business.industry, Sentinel lymph node, medicine, Radiology, business, Indocyanine green
Published
2020

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