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1. Incidence, prevalence and clinical presentation of inflammatory bowel diseases in Northern France: a 30-year population-based studyResearch in context

Author

Hélène Sarter, Thibaut Crétin, Guillaume Savoye, Mathurin Fumery, Ariane Leroyer, Luc Dauchet, Thierry Paupard, Hugues Coevoet, Pauline Wils, Nicolas Richard, Dominique Turck, Delphine Ley, Corinne Gower-Rousseau, Eric Agoute, Najib Al Ghossaini, Raied Al Hameedi, Myriam Al Khatib, Saria Al Turk, Jean-Marie Andre, Matthieu Antoine, Michel Antonietti, Amar Aouakli, Laura Armengol-Debeir, Ibrahim Aroichane, Fadi Assi, Eric Auxenfants, Alina Avram, Kassem Azzouzi, Damyan Bankovski, Bernard Barbry, Nicolas Bardoux, Philippe Baron, Anne Baudet, Pauline Bayart, Brice Bazin, Arash Bebahani, Jean-Pierre Becqwort, Houssem Ben Ali, Emmanuel Ben Soussan, Coralie Benard, Vincent Benet, Corinne Benguigui, Abdeslam Bental, Sara Bentaleb-Bellati, Isabelle Berkelmans, Jacques Bernet, Karine Bernou, Nathalie Bertiaux-Vandaele, Pauline Bertot, Valérie Bertrand, Emilie Biloud, Nathalie Biron, Benjamin Bismuth, Cyril Blanchard, Maurice Bleuez, Fabienne Blondel, Valérie Blondin, Marius Bobula, Philippe Bohont, Eléonore Boivin, Vanessa Bon Djemah, Eric Boniface, Philippe Bonniere, Pierre Bonvarlet, Arnaud Boruchowicz, Raoul Bostvironnois, Médina Boualit, Ahlem Bouazza, Bruno Bouche, Christian Boudailler, Claude Bourgeaux, Morgane Bourgeois-Fumery, Arnaud Bourguet, Agnès Bourienne, Hamza Boutaleb, Alexis Bouthors, Julien Branche, Franck Brazier, Marie Bridenne, Hélène Brihier, Laura Bril, Philippe Bulois, Pierre Burgiere, Joël Butel, Jean-Yves Canva, Valérie Canva-Delcambre, Florence Cardot, Sandrine Carette, Pierre Carpentier, Michel Cassagnou, Jean-François Cassar, François Castex, Pascale Catala, Stéphane Cattan, Sylviane Catteau, Bernard Caujolle, Gérard Cayron, Catherine Chandelier, Cloé Charpentier, Marthe Chavance-Thelu, Agathe Cheny, Dinu Chirita, Antoine Choteau, Jean-François Claerbout, Pierre-Yves Clergue, Gil Cohen, Marie Colin, Régis Collet, Jean-Frédéric Colombel, Stéphanie Coopman, Lucie Cordiez, Antoine Cortot, Jean Corvisart, Frédéric Couttenier, Jean-François Crinquette, Valérie Crombe, Abdelhakim Daoudi, Vincent Dapvril, Thierry Davion, Sébastien Decoster, Laurent Defontaine, Nicolas Degrave, Aurélien Dejaeger, Richard Delcenserie, Marine Deleplanque, Dorothée Delesalle, Olivier Delette, Thierry Delgrange, Laurence Delhoustal, Jean-Stéphane Delmotte, Sabri Demmane, Guy Deregnaucourt, Constance Deschepper, Jean-Pierre Desechalliers, Patrick Desmet, Pierre Desreumaux, Gérard Desseaux, Philippe Desurmont, Alain Devienne, Eve Devouge, Alex Devroux, Arnaud Dewailly, Sébastien Dharancy, Aude Di Fiore, Emmanuel Diaz, Djamal-Dine Djeddi, Rachid Djedir, Wissam Doleh, Marie-Laure Dreher-Duwat, Richard Dubois, Clothilde Duburque, Frédéric Ducrot, Philippe Ducrotte, André Dufilho, Christian Duhamel, Caroline Dumant-Forest, Jean-Louis Dupas, Frédéric Dupont, Yves Duranton, Arnaud Duriez, Nicolas Duveau, Mohammadi El Farisi, Khalil El Hachkar, Caroline Elie, Marie-Claire Elie-Legrand, Matthieu Eoche, Essmaeel Essmaeel, Dominique Evrard, Jean-Paul Evrard, Armelle Fatome, Karima Fellah-Sekkai, Bernard Filoche, Laurent Finet, Mathilde Flahaut, Camille Flamme, David Foissey, Peggy Fournier, Philippe Foutrein, Marie-Christine Foutrein-Comes, Thierry Frere, Julie Galand, Philippe Gallais, Claudine Gamblin, Serge Ganga, Romain Gerard, Guillaume Geslin, Yves Gheyssens, Salah Ghrib, Thierry Gilbert, Bénédicte Gillet, Denis Godart, Jean-Michel Godchaux, Guetty Goeguebeur, Odile Goria, Frédéric Gottrand, Philippe Gower, Lucien Grados, Brigitte Grandmaison, Marion Groux, Claire Guedon, Loïc Guerbeau, Mathilde Gueroult-Dero, Jean-François Guillard, Laurence Guillem, François Guillemot, Dominique Guimber, Baya Haddouche, Vincent Hautefeuille, Philippe Hecketsweiller, Geneviève Hecquet, Jean-Pierre Hedde, Hassina Hellal, Pierre-Emmanuel Henneresse, Michel Heraud, Sophie Herve, Bruno Heyman, Patrick Hochain, Philippe Houcke, Lucie Houssin-Baillly, Bruno Huguenin, Silviu Iobagiu, Shata Istanboli, Alexsandar Ivanovic, Isabelle Iwanicki-Caron, Eric Janicki, Marine Jarry, Charlotte Jean Bart, Claude Jonas, Julia Jougon, Anne Jouvenet, Naeim Kassar, Fadi Katherin, Alfred Kerleveo, Ali Khachfe, Alfred Kiriakos, Jean Kiriakos, Olivier Klein, Matthieu Kohut, Richard Kornhauser, Demetrios Koutsomanis, Jean-Eric Laberenne, Eric Lacotte, Guy Laffineur, Marine Lagarde, Anouck Lahaye, Arnaud Lalanne, Ambroise Lalieu, Pierre Lannoy, José Lapchin, Michel Laprand, Denis Laude, Christian Le Couteulx, Charles Le Goffic, Alain Le Grix, Jean-Philippe Le Mouel, Pauline Le Roy, Rachida Leblanc, Paul Lecieux, Stéphane Lecleire, Nathalie Leclerc, Jean Ledent, Jean Lefebvre, Pascale Lefilliatre, Céline Legrand, Patrick Lelong, Bernard Leluyer, Caroline Lemaitre, Lucie Lepileur, Antoine Leplat, Elodie Lepoutre-Dujardin, Gabriel Leppeut, Henri Leroi, Maryvonne Leroy, Benoît Lesage, Jocelyn Lesage, Xavier Lesage, Isabelle Lescanne-Darchis, Dominique Lescut, Bruno Leurent, Michel Lhermie, Louise Libier, Bernard Lisambert, Isabelle Loge, Julien Loreau, Alexandre Louvet, Joséphine Lozinguez, Henri Lubrez, Damien Lucidarme, Jean-Jacques Lugand, Olivier Macaigne, Denis Maetz, Dominique Maillard, Hubert Mancheron, Olivia Manolache, Anne-Bérengère Marks-Brunel, Charline Marre, Raymond Marti, Eric Marzloff, Philippe Mathurin, Jacques Mauillon, Vincent Maunoury, Jean-Luc Maupas, Michèle-Ange Medam Djomo, Chloé Melchior, Ziad Melki, B. Mesnard, Patrice Metayer, Lofti Methari, Franck Meurisse, Laurent Michaud, Patricia Modaine, Angélique Monthe, Loïk Morel, Mathilde Morin, Pierre-Eugène Mortier, Perrine Mortreux, Olivier Mouterde, Nicolas Mozziconaci, Jean Mudry, Maria Nachuri, Minh Dung Ngo, Eric N'guyen Khac, Bertrand Notteghem, Vincent Ollevier, Atika Ouraghi, Barriza Oussadou, Dominique Ouvry, Bernard Paillot, Claire Painchart, Nicole Panien-Claudot, Christian Paoletti, Arsène Papazian, Bruno Parent, Jean-Claude Paris, Philippe Patrier, Bernard Pauwels, Mathieu Pauwels, Richard Petit, Muriel Piat, Sandrine Piotte, Christophe Plane, Bernard Plouvier, Eric Pollet, Pierre Pommelet, Daniela Pop, Charlotte Pordes, Gérard Pouchain, Philippe Prades, Jean-Christophe Prevost, Manon Pruit, Gilles Quartier, Anne-Marie Queuniet, Jean-François Quinton, Alain Rabache, Gilles Raclot, Sébastien Ratajczyk, Nicole Reix, Thibaud Renaut-Vantroys, Marine Revillion, Ghassan Riachi, Clémentine Riault, Cécile Richez, Benoît Rimbert, Philippe Robinson, Juan Daniel Rodriguez, Jean Roger, Jean-Marc Roux, Alain Rudelli, Clémence Saingier, Patrick Schlossberg, David Sefrioui, Michel Segrestin, David Seguy, Célik Seminur, François Sevenet, Jean Silvie, Claire Spyckerelle, Nathalie Talbodec, Noémie Tavernier, Henriette Tchandeu, Aurore Techy, Jean-Luc Thelu, Henri Thiebault, Jean-Marie Thorel, Christophe Thuillier, Guillaume Tielman, Manuella Tode, Jean Tonnel, Jean-Yves Touchais, Audrey Toulemonde-Huguet, Pierre Toumelin, Yvan Touze, Léa Tran, Jean-Luc Tranvouez, Nadia Triki, Justine Turpin, Eric Vaillant, Claude Valmage, Dominique Vanco, Nathalie Vandaele-Bertiaux, Hélène Vandamme, Elise Vander Eeken, Etienne Vanderbercq, Philippe Vandermollen, Philippe Vandevenne, Lionel Vandeville, Alain Vandewalle, Jean-Pierre Vanhoove, Audrey Vanrenterghem, Charlotte Vanveuren, Iona Vasies, Guy Verbiese, Juliette Verlynde, Philippe Vermelle, Christine Verne, Gwenola Vernier-Massouille, Perrine Vezelier-Cocq, Juliette Viart, Benoît Vigneron, Marc Vincendet, Jacques Viot, Y.M. Voiment, Jean-Yves Wallez, Michel Wantier, Faustine Wartel, Jean-Christian Weber, Jean-Louis Willocquet, Nathalie Wizla, Eric Wolschies, Tajiogue Yimfor, Oana Zahara, Alberto Zalar, Sonia Zaoui, and Anne Zellweger

Subjects
Inflammatory bowel disease, Incidence, Prevalence, Population-based registry, Crohn’s disease, Ulcerative colitis, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: In industrialized countries, the incidence of inflammatory bowel disease (IBD) appears stabilized. This study examined the incidence and phenotype of IBD in Northern France over a 30-year period. Methods: Including all IBD patients recorded in the EPIMAD population-based registry from 1988 to 2017 in Northern France, we described the incidence and clinical presentation of IBD according to age, sex and time. Findings: A total of 22,879 incident IBD cases were documented (59% (n = 13,445) of Crohn’s disease (CD), 38% (n = 8803) of ulcerative colitis (UC), 3% (n = 631) of IBD unclassified (IBDU)). Over the study period, incidence of IBD, CD and UC was 12.7, 7.2 and 5.1 per 105 person-years, respectively. The incidence of CD increased from 5.1/105 in 1988–1990 to 7.9/105 in 2015–2017 (annual percent change (APC): +1.9%, p

Published
2024
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2. Prebiotic Supplementation during Lactation Affects Microbial Colonization in Postnatal-Growth-Restricted Mice

Author

Lucie Marousez, Léa Chantal Tran, Edwina Micours, Matthieu Antoine, Frédéric Gottrand, Jean Lesage, and Delphine Ley

Subjects
prebiotic fiber, PNGR, maturation, microbial colonization, short-chain fatty acids, Nutrition. Foods and food supply, TX341-641
Abstract

Background: An inadequate perinatal nutritional environment can alter the maturation of the intestinal barrier and promote long-term pathologies such as metabolic syndrome or chronic intestinal diseases. The intestinal microbiota seems to play a determining role in the development of the intestinal barrier. In the present study, we investigated the impact of consuming an early postnatal prebiotic fiber (PF) on growth, intestinal morphology and the microbiota at weaning in postnatal-growth-restricted mice (PNGR). Methods: Large litters (15 pups/mother) were generated from FVB/NRj mice to induce PNGR at postnatal day 4 (PN4) and compared to control litters (CTRL, 8 pups/mother). PF (a resistant dextrin) or water was orally administered once daily to the pups from PN8 to PN20 (3.5 g/kg/day). Intestinal morphology was evaluated at weaning (PN21) using the ileum and colon. Microbial colonization and short-chain fatty acid (SCFA) production were investigated using fecal and cecal contents. Results: At weaning, the PNGR mice showed decreased body weight and ileal crypt depth compared to the CTRL. The PNGR microbiota was associated with decreased proportions of the Lachnospiraceae and Oscillospiraceae families and the presence of the Akkermansia family and Enterococcus genus compared to the CTRL pups. The propionate concentrations were also increased with PNGR. While PF supplementation did not impact intestinal morphology in the PNGR pups, the proportions of the Bacteroides and Parabacteroides genera were enriched, but the proportion of the Proteobacteria phylum was reduced. In the CTRL pups, the Akkermansia genus (Verrucomicrobiota phylum) was present in the PF-supplemented CTRL pups compared to the water-supplemented ones. Conclusions: PNGR alters intestinal crypt maturation in the ileum at weaning and gut microbiota colonization. Our data support the notion that PF supplementation might improve gut microbiota establishment during the early postnatal period.

Published
2023
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3. Tube Feeding in Neurologically Disabled Children: Hot Topics and New Directions

Author

Valeria Dipasquale, Madeleine Aumar, Delphine Ley, Matthieu Antoine, Claudio Romano, and Frédéric Gottrand

Subjects
gastrostomy, informed consent, neurological disability, pediatrics, tube feeding, tube weaning, Nutrition. Foods and food supply, TX341-641
Abstract

Tube feeding is a therapeutic intervention that is aimed at providing nutritional support and is important in the nutritional and gastrointestinal management of children with neurological disability (ND) worldwide. Since the publication of the first European Society of Gastroenterology, Hepatology, and Nutrition (ESPGHAN) consensus paper in 2017, some aspects of tube-feeding modalities have attracted the interest of the scientific community more than others, including the type of enteral formulas, enteral access, and the challenging practice of tube weaning. The purpose of this review was to report on the most recent hot topics and new directions in tube-feeding strategies for children with ND.

Published
2022
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4. Complications of One-step Button Percutaneous Endoscopic Gastrostomy in Children

Author

Charlotte Jean-Bart C, Madeleine Aumar, Delphine Ley, Matthieu Antoine, Emeline Cailliau, Stéphanie Coopman, Dominique Guimber, Serge Ganga, Dominique Turck, and Frédéric Gottrand

Subjects
Pediatrics, Perinatology and Child Health
Abstract

Purpose To assess the complications of one-step button percutaneous endoscopic gastrostomy (B-PEG) and determine risk factors for developing stomal infections or gastropexy complications. Methods A retrospective study of 679 children who underwent a B-PEG procedure in a single tertiary care center over a 10-year period to December 2020 was conducted. Patient characteristics, early complications (occurring ≤7 days after the procedure), late complications (> 7 days after the procedure), and outcomes were collected from medical records. A list of potential risk factors, including age at procedure, prematurity, underlying neurological disease, and undernutrition, was determined a priori. Results At least 1 year of follow-up was available for 513 patients. Median follow-up duration was 2.8 years (interquartile range 1.0–4.9 years). Major complications were rare (p = .042) was a risk factor for developing peristomal infection. T-fastener migration occurred in 17.3% of children, and we found underlying neurological disease was a protective factor (OR 0.59 [0.37–0.92], p = .019). Conclusion B-PEG is a safe method and associated with a low rate of local infection. However, T-fasteners are associated with significant morbidity and require particular attention in young and premature infants.

Published
2022

5. Factors associated with the underuse of adrenaline in children with anaphylaxis

Author

Guillaume, Pouessel, Matthieu, Antoine, Adeline, Pierache, François, Dubos, Stéphanie, Lejeune, Antoine, Deschildre, and Capucine, Trochu

Subjects
Male, 0301 basic medicine, Emergency Medical Services, medicine.medical_specialty, Adolescent, Epinephrine, Immunology, Injections, Intramuscular, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Food allergy, medicine, Emergency medical services, Humans, Immunology and Allergy, Practice Patterns, Physicians', Sympathomimetics, Child, Anaphylaxis, business.industry, medicine.disease, 030104 developmental biology, 030228 respiratory system, Adrenaline injection, Child, Preschool, Practice Guidelines as Topic, Emergency medicine, Female, France, Emergency Service, Hospital, business, Food Hypersensitivity
Abstract

Intramuscular adrenaline injection is the first-line treatment of anaphylaxis [1]. More serious and even fatal or biphasic reactions may occur if there is a delay in administering it [1]. Adrenaline injection for anaphylaxis that occurs outside of a healthcare setting should be immediately followed by a call to emergency medical services (EMS) ("911" in North America, "112" in Europe) [1]. Before discharge from the emergency care unit (ECU), an adrenaline auto-injector (AAI) should be prescribed with clearly written instructions for its use and safety recommendations [1].

Published
2021

6. Recurrent food anaphylaxis and risk factors in children

Author

Guillaume, Pouessel, Marie, Balerdi, Stéphanie, Lejeune, Valérie, Deken, François, Dubos, Matthieu, Antoine, Antoine, Deschildre, and C, Trochu

Subjects
medicine.medical_specialty, business.industry, Immunology, MEDLINE, Risk Factors, Food anaphylaxis, Pediatrics, Perinatology and Child Health, medicine, Humans, Immunology and Allergy, Child, Intensive care medicine, business, Anaphylaxis, Food Hypersensitivity
Published
2021

7. Endoscopic Gastrojejunostomy in Infants and Children

Author

Sophia Elmehdi, Delphine Ley, Madeleine Aumar, Stéphanie Coopman, Dominique Guimber, Audrey Nicolas, Matthieu Antoine, Dominique Turck, Maeva Kyheng, and Frédéric Gottrand

Subjects
Gastrostomy, Enteral Nutrition, Pneumoperitoneum, Pediatrics, Perinatology and Child Health, Gastric Bypass, Humans, Infant, Child, Intubation, Gastrointestinal, Retrospective Studies
Abstract

To evaluate the feasibility of endoscopic gastrojejunal tube (GJT) placement in infants and children.All children undergoing endoscopic GJT placement between January 2010 and December 2019 were included in this single-center retrospective study. Difficulties with and failure of GJT placement, complication rates, and device longevity, efficacy, and duration were assessed.A total of 107 children, median age 10 months (IQR, 5.0-23.0 months) and median weight 6.6 kg (IQR, 5.3-9.5 kg), underwent endoscopic GJT placement using the gastric stoma to introduce the endoscope (one step: n = 36 of 107; 33.6%). Endoscopic placement was successful in 99%. Eight periprocedure complications occurred, including 1 pneumoperitoneum requiring exsufflation, 2 acute pulmonary hypertension episodes leading to death in 1 case, and 5 episodes of bronchospasm. Minor complications were frequent and mostly mechanical (79%), whereas major complications were rare (5.6%): intussusception (n = 4), intestinal perforation (n = 1), and pneumoperitoneum (n = 1). Ten patients died. Of the 97 patients who lived, 85 (87%) were weaned from jejunal feeding at a median of 179 days (IQR, 69-295 days) after initiation. Among them, 30 (35.2%) required fundoplication. Weight for age z-score was significantly higher at weaning.GJT placement is feasible in children, even low-weight infants. Complications are frequent but are mostly minor.

Published
2021

9. Prise en charge de l’anaphylaxie dans les services d’urgences pédiatriques dans le Nord-Pas-de-Calais (2015–2017)

Author

Antoine Deschildre, Guillaume Pouessel, F. Dubos, A. Pierache, and Matthieu Antoine

Subjects
Immunology and Allergy
Abstract

Introduction Le traitement de premiere ligne de l’anaphylaxie repose sur l’injection intramusculaire precoce d’adrenaline. De nombreuses etudes identifient une prise en charge insuffisante avant et pendant les soins aux urgences mais les facteurs associes a une prise en charge adequate ne sont pas identifies. Methodes Les enfants ( Resultats 149 patients (âge moyen : 7,4 ± 4,7 ans, garcons : 58 %) etaient inclus ; les antecedents etaient une allergie connue (51 %), un asthme (39 %), une anaphylaxie (11 %). Les aliments (arachide, 21 % ; fruits a coque, 23 %) etaient en cause dans 73 % des reactions et 15 % des reactions etaient idiopathiques. Douze (8 %) enfants ont eu une anaphylaxie au cours d’une induction de tolerance orale. Il existait un defaut d’appel des secours par les familles (56 %) et un defaut d’envoi de secours medicalises malgre l’appel des secours (27 %). Le taux global d’utilisation d’adrenaline etait de 48 % (par l’entourage, 11 % ; en pre-hospitalier, 7 %, aux urgences, 34 %). Tenant compte de la resolution spontanee des signes (36 % des cas a l’admission aux urgences), 42 % des enfants avaient une prise en charge adaptee de facon globale (pre-hospitalier, 9 % ; aux urgences, 55 %). L’adrenaline etait plus utilisee chez les enfants plus âges (p = 0,031). La prise en charge etait d’autant plus adaptee aux urgences que le score de gravite Ring etait eleve (p = 0,004) et par l’equipe de secours si l’allergie etait liee a l’arachide (p = 0,034). L’absence de reconnaissance de la gravite potentielle etait le facteur le plus cite dans la non-utilisation de l’adrenaline par les medecins. Conclusion Il existe des freins a une prise en charge adequate de l’anaphylaxie a differents niveaux : attitude du patient et de son entourage, soins pre-hospitaliers et aux urgences. Des etudes a plus large echelle sont necessaires pour mieux apprehender les facteurs de risque de reactions graves ou recurrentes.

Published
2019

10. D.D. Bartholomaei Caepollae Tractatus de seruitutibus, tam urbanorum, quàm rusticorum praediorum : accedunt D. Martini Laud. & Jo. Superioris commentarii ad leges singulas de servitutibus : item Antonii Matthaei Disputationes VII de seruitutibus : et huic editioni, quae in hactenus editis non habentur Gottliebi Gerhardi Titii de servitute faciendi et Christiani Thomasii de servitute stillicidii Dissertationes.

Author

Bousquet, Marc Michel, ed. lit, Cipolla, Bartolomeo, m. 1477, Laud, Martinus, Superior, Johannes, Titino, Gottlieb Gerardus, Matthieu, Antoine, Bousquet, Marc Michel, ed. lit, Cipolla, Bartolomeo, m. 1477, Laud, Martinus, Superior, Johannes, Titino, Gottlieb Gerardus, and Matthieu, Antoine

Abstract

Port. con grab. xil., posible marca tip, Sign.: [cruz latina]\p4\s, A-4N\p4\s, 4O\p2\s, Port. a dos tintas, Texto a dos col

11. D.D. Bartholomaei Caepollae Tractatus de servitutibus, tam urbanorum quam rusticorum praediorum : accedunt D. Laud. & Jo. Superioris commentarii ad leges singulas de servitutibus : item Antonii Matthaei Disputationes VII de servitutibus, et huic editioni quae in hactenus editis non habentur Gottliebi Gerhardi Titii de servitute faciendi et Christiani Thomasii de servitute stillicidii dissertationes

Author

Bousquet, Marc Michel, ed. lit, CEPOLLA, Bartolomeo, Laud, Martinus, Superior, Johannes, Titi, Gottlieb Gerard, Matthieu, Antoine, Thomas, Christian, Bousquet, Marc Michel, ed. lit, CEPOLLA, Bartolomeo, Laud, Martinus, Superior, Johannes, Titi, Gottlieb Gerard, Matthieu, Antoine, and Thomas, Christian

Abstract

Sign.:[cruz latina]\p4\s, A-Z\p4\s, 2A-2Z\p4\s, 3A-3Z\p4\s, 4A-4N\p4\s, 4O\p2\s, Port. a dúas tintas con grav. xil, Texto a dúas col

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