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3 results on '"Matthias, Hutten"'

1. Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome

Author

Rolf Felix Maier, Mario Rüdiger, Nadine Mand, Matthias Hutten, and Ulrich Pecks

Subjects
Pediatrics, RJ1-570
Abstract

SARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary in planned pregnancy. Using data from the CRONOS registry, we compared pregnancy outcomes according to VOC and vaccination status. We found that vaccination during pregnancy reduced preterm birth rates compared with unvaccinated or vaccinated women with Omicron infection, without increasing severe neonatal outcomes. Given the risks associated with preterm birth, the study consistently supports vaccination recommendations for women planning pregnancy.

Published
2025
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2. Closed-Loop Control of Arterial CO

Author

Mateusz, Buglowski, Valerie, Pfannschmidt, Sabine, Becker, Oliver, Braun, Matthias, Hutten, Daan, Ophelders, Camelia, Oprea, Steffen, Pattai, Mark, Schoberer, and Andre, Stollenwerk

Subjects
Sheep, Partial Pressure, Respiration, Tidal Volume, Animals, Carbon Dioxide, Respiration, Artificial
Abstract

During mechanical ventilation of the neonate the main goal is to stabilize respiratory function of the often premature lungs. Ventilating the patient without inflicting harm is then the subordinated next goal. Ideally the arterial partial pressure of CO

Published
2022

3. Neonatal outcome following maternal infection with SARS-CoV-2 in Germany: COVID-19-Related Obstetric and Neonatal Outcome Study (CRONOS)

Author

Nadine, Mand, Antonella, Iannaccone, Ann-Carolin, Longardt, Matthias, Hutten, Lars, Mense, Peter, Oppelt, Rolf Felix, Maier, Ulrich, Pecks, Mario, Rüdiger, Sönke, Ebert, MUMC+: MA Medische Staf Kindergeneeskunde (9), RS: GROW - R4 - Reproductive and Perinatal Medicine, and Kindergeneeskunde

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Offspring, viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Medizin, Pregnancy, Outcome Assessment, Health Care, Epidemiology, medicine, Humans, Neonatology, Pregnancy Complications, Infectious, SARS-CoV-2, Obstetrics, business.industry, Infant, Newborn, Pregnancy Outcome, COVID-19, Obstetrics and Gynecology, General Medicine, medicine.disease, Infectious Disease Transmission, Vertical, Maternal infection, Neonatal infection, Pediatrics, Perinatology and Child Health, Premature Birth, Female, business
Abstract

SARS-CoV-2 infections in pregnant women and the consequences for their offspring are summarised in various reviews,1 2 but data on the impact of time of SARS-CoV-2 infection during pregnancy on neonatal morbidity are still inconclusive.3 4 CRONOS (COVID-19-Related Obstetric and Neonatal Outcome Study) is a prospective German registry enrolling pregnant women with confirmed SARS-CoV-2 infection during their pregnancy.5 SARS-CoV-2 infection is defined as detection of viral RNA by PCR testing or detection of maternal SARS-CoV-2 antibodies. Neonatal infection is defined as detection of viral RNA by PCR testing of a nasopharyngeal/oropharyngeal or rectal swab. For the present analysis, time of maternal infection was categorised into ‘early’ or ‘late’ if women tested positive for SARS-CoV-2 more or less than 2 weeks prior to delivery, respectively. Data obtained between 3 April and 27 November 2020 were analysed, using 74 hospitals (73 German and 1 Austrian) comprising approximately 20% of German births. Within the study period 435 newborns were entered into the registry, 4 …

Published
2021
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