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1. Accumulation of copy number alterations and clinical progression across advanced prostate cancer

Author

Grist, Emily, Friedrich, Stefanie, Brawley, Christopher, Mendes, Larissa, Parry, Marina, Ali, Adnan, Haran, Aine, Hoyle, Alex, Gilson, Claire, Lall, Sharanpreet, Zakka, Leila, Bautista, Carla, Landless, Alex, Nowakowska, Karolina, Wingate, Anna, Wetterskog, Daniel, Hasan, A. M. Mahedi, Akato, Nafisah B., Richmond, Malissa, Ishaq, Sofeya, Matthews, Nik, Hamid, Anis A., Sweeney, Christopher J., Sydes, Matthew R., Berney, Daniel M., Lise, Stefano, Parmar, Mahesh K. B., Clarke, Noel W., James, Nicholas D., Cremaschi, Paolo, Brown, Louise C., and Attard, Gerhardt

Published
2022
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3. Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer

Author

Wagner, Steve, Vlachogiannis, Georgios, De Haven Brandon, Alexis, Valenti, Melanie, Box, Gary, Jenkins, Liam, Mancusi, Caterina, Self, Annette, Manodoro, Floriana, Assiotis, Ioannis, Robinson, Penny, Chauhan, Ritika, Rust, Alistair G., Matthews, Nik, Eason, Kate, Khan, Khurum, Starling, Naureen, Cunningham, David, Sadanandam, Anguraj, Isacke, Clare M., Kirkin, Vladimir, Valeri, Nicola, and Whittaker, Steven R.

Published
2019
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6. Data from Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

Author

Murugaesu, Nirupa, primary, Wilson, Gareth A., primary, Birkbak, Nicolai J., primary, Watkins, Thomas B.K., primary, McGranahan, Nicholas, primary, Kumar, Sacheen, primary, Abbassi-Ghadi, Nima, primary, Salm, Max, primary, Mitter, Richard, primary, Horswell, Stuart, primary, Rowan, Andrew, primary, Phillimore, Benjamin, primary, Biggs, Jennifer, primary, Begum, Sharmin, primary, Matthews, Nik, primary, Hochhauser, Daniel, primary, Hanna, George B., primary, and Swanton, Charles, primary

Published
2023
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7. Supplementary Table S3 from Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

Author

Murugaesu, Nirupa, primary, Wilson, Gareth A., primary, Birkbak, Nicolai J., primary, Watkins, Thomas B.K., primary, McGranahan, Nicholas, primary, Kumar, Sacheen, primary, Abbassi-Ghadi, Nima, primary, Salm, Max, primary, Mitter, Richard, primary, Horswell, Stuart, primary, Rowan, Andrew, primary, Phillimore, Benjamin, primary, Biggs, Jennifer, primary, Begum, Sharmin, primary, Matthews, Nik, primary, Hochhauser, Daniel, primary, Hanna, George B., primary, and Swanton, Charles, primary

Published
2023
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8. Supplementary Methods, Tables S1 - S2, S4, Figures S1 - S11 from Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

Author

Murugaesu, Nirupa, primary, Wilson, Gareth A., primary, Birkbak, Nicolai J., primary, Watkins, Thomas B.K., primary, McGranahan, Nicholas, primary, Kumar, Sacheen, primary, Abbassi-Ghadi, Nima, primary, Salm, Max, primary, Mitter, Richard, primary, Horswell, Stuart, primary, Rowan, Andrew, primary, Phillimore, Benjamin, primary, Biggs, Jennifer, primary, Begum, Sharmin, primary, Matthews, Nik, primary, Hochhauser, Daniel, primary, Hanna, George B., primary, and Swanton, Charles, primary

Published
2023
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10. Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment

Author

Newey, Alice, Griffiths, Beatrice, Michaux, Justine, Pak, Hui Song, Stevenson, Brian J., Woolston, Andrew, Semiannikova, Maria, Spain, Georgia, Barber, Louise J., Matthews, Nik, Rao, Sheela, Watkins, David, Chau, Ian, Coukos, George, Racle, Julien, Gfeller, David, Starling, Naureen, Cunningham, David, Bassani-Sternberg, Michal, and Gerlinger, Marco

Published
2019
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11. CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

Author

Gonzalez-Exposito, Reyes, Semiannikova, Maria, Griffiths, Beatrice, Khan, Khurum, Barber, Louise J., Woolston, Andrew, Spain, Georgia, von Loga, Katharina, Challoner, Ben, Patel, Radhika, Ranes, Michael, Swain, Amanda, Thomas, Janet, Bryant, Annette, Saffery, Claire, Fotiadis, Nicos, Guettler, Sebastian, Mansfield, David, Melcher, Alan, Powles, Thomas, Rao, Sheela, Watkins, David, Chau, Ian, Matthews, Nik, Wallberg, Fredrik, Starling, Naureen, Cunningham, David, and Gerlinger, Marco

Published
2019
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13. Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Author

Abbosh, Christopher, Birkbak, Nicolai J., Wilson, Gareth A., Jamal-Hanjani, Mariam, Constantin, Tudor, Salari, Raheleh, Le Quesne, John, Moore, David A., Veeriah, Selvaraju, Rosenthal, Rachel, Marafioti, Teresa, Kirkizlar, Eser, Watkins, Thomas B. K., McGranahan, Nicholas, Ward, Sophia, Martinson, Luke, Riley, Joan, Fraioli, Francesco, Al Bakir, Maise, Grnroos, Eva, Zambrana, Francisco, Endozo, Raymondo, Bi, Wenya Linda, Fennessy, Fiona M., Sponer, Nicole, Johnson, Diana, Laycock, Joanne, Shafi, Seema, Czyzewska-Khan, Justyna, Rowan, Andrew, Chambers, Tim, Matthews, Nik, Turajlic, Samra, Hiley, Crispin, Lee, Siow Ming, Forster, Martin D., Ahmad, Tanya, Falzon, Mary, Borg, Elaine, Lawrence, David, Hayward, Martin, Kolvekar, Shyam, Panagiotopoulos, Nikolaos, Janes, Sam M., Thakrar, Ricky, Ahmed, Asia, Blackhall, Fiona, Summers, Yvonne, Hafez, Dina, Naik, Ashwini, Ganguly, Apratim, Kareht, Stephanie, Shah, Rajesh, Joseph, Leena, Marie Quinn, Anne, Crosbie, Phil A., Naidu, Babu, Middleton, Gary, Langman, Gerald, Trotter, Simon, Nicolson, Marianne, Remmen, Hardy, Kerr, Keith, Chetty, Mahendran, Gomersall, Lesley, Fennell, Dean A., Nakas, Apostolos, Rathinam, Sridhar, Anand, Girija, Khan, Sajid, Russell, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-Sellers, Melanie, Prakash, Vineet, Lester, Jason F., Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Oukrif, Dahmane, Akarca, Ayse U., Hartley, John A., Lowe, Helen L., Lock, Sara, Iles, Natasha, Bell, Harriet, Ngai, Yenting, Elgar, Greg, Szallasi, Zoltan, Schwarz, Roland F., Herrero, Javier, Stewart, Aengus, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Lin, C. Jimmy, Rabinowitz, Matthew, Aerts, Hugo J. W. L., Hackshaw, Allan, Shaw, Jacqui A., Zimmermann, Bernhard G., Swanton, Charles, Bosshard-Carter, Leticia, Goh, Gerald, Gorman, Pat, Murugaesu, Nirupa, Hynds, Robert E., Horswell, Stuart, Bakir, Maise Al, Mitter, Richard, Escudero, Mickael, Xu, Hang, Goldman, Jacki, Stone, Richard Kevin, Denner, Tamara, Biggs, Jennifer, Costa, Marta, Begum, Sharmin, Phillimore, Ben, Nye, Emma, Graca, Sofia, Joshi, Kroopa, Furness, Andrew, Ben Aissa, Assma, Wong, Yien Ning Sophia, Georgiou, Andy, Simeon, Celia, Hector, Gemma, Smith, Amy, Aranda, Marie, Novelli, Marco, Papadatos-Pastos, Dionysis, Carnell, Dawn, Mendes, Ruheena, George, Jeremy, Navani, Neal, Taylor, Magali, Choudhary, Junaid, Califano, Raffaele, Taylor, Paul, Krysiak, Piotr, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Evison, Matthew, Moss, Stuart, Idries, Faiza, Bishop, Paul, Chaturvedi, Anshuman, Quinn, Anne Marie, Doran, Helen, Leek, Angela, Harrison, Phil, Moore, Katrina, Waddington, Rachael, Novasio, Juliette, Rogan, Jane, Smith, Elaine, Tugwood, Jonathan, Brady, Ged, Rothwell, Dominic G., Chemi, Francesca, Pierce, Jackie, Gulati, Sakshi, Bellamy, Mary, Bancroft, Hollie, Kerr, Amy, Kadiri, Salma, Webb, Joanne, Djearaman, Madava, Quesne, John Le, Thomas, Anne, Walter, Harriet, Monteiro, William, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Primrose, Lindsay, Amadi, Anita, Palmer, Shirley, Miller, Joy, Buchan, Keith, Edwards, Alison, Morgan, Fiona, Verjee, Azmina, MacKenzie, Mairead, Wilcox, Maggie, Smith, Sean, Gower, Nicole, Ottensmeier, Christian, Chee, Serena, Johnson, Benjamin, Alzetani, Aiman, Shaw, Emily, Lim, Eric, De Sousa, Paulo, Barbosa, Monica Tavares, Bowman, Alex, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Cufari, Maria Elena, Ronquillo, John Carlo, Kwayie, Angela, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Buderi, Silviu, Finch, Jonathan, Azcarate, Leire, Chavan, Hema, Green, Sophie, Mashinga, Hillaria, Nicholson, Andrew G., Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Conibear, John, Light, Teresa, Horey, Tracey, Danson, Sarah, Bury, Jonathan, Edwards, John, Hill, Jennifer, Matthews, Sue, Kitsanta, Yota, Suvarna, Kim, Fisher, Patricia, Keerio, Allah Dino, Shackcloth, Michael, Gosney, John, Postmus, Pieter, Feeney, Sarah, Asante-Siaw, Julius, Dentro, Stefan, and Dessimoz, Christophe

Subjects
Lung cancer -- Genetic aspects -- Development and progression, DNA sequencing -- Methods, Phylogeny -- Observations, Cancer metastasis -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies., Author(s): Christopher Abbosh [1]; Nicolai J. Birkbak [1, 2]; Gareth A. Wilson [1, 2]; Mariam Jamal-Hanjani [1]; Tudor Constantin [3]; Raheleh Salari [3]; John Le Quesne [4]; David A. Moore [...]

Published
2017
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14. CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

Author

Roulstone, Victoria, primary, Kyula, Joan, additional, Wright, James, additional, Yu, Lu, additional, Alonso, Aida Barreiro, additional, Melake, Miriam, additional, Choudhary, Jyoti, additional, Elliott, Richard, additional, Lord, Christopher J., additional, Mansfield, David, additional, Matthews, Nik, additional, Chauhan, Ritika, additional, Jennings, Victoria, additional, Chan, Charleen, additional, Baldock, Holly, additional, Butera, Francesca, additional, Appleton, Elizabeth, additional, Nenclares, Pablo, additional, Pederson, Malin, additional, Foo, Shane, additional, Patin, Emmanuel C., additional, Rullan, Antonio, additional, Tenev, Tencho, additional, Meier, Pascal, additional, Van Vloten, Jacob, additional, Vile, Richard, additional, Pandha, Hardev, additional, Melcher, Alan, additional, McLaughlin, Martin, additional, and Harrington, Kevin, additional

Published
2022
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15. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

Author

de Bruin, Elza C., McGranahan, Nicholas, Mitter, Richard, Salm, Max, Wedge, David C., Yates, Lucy, Jamal-Hanjani, Mariam, Shafi, Seema, Murugaesu, Nirupa, Rowan, Andrew J., Grönroos, Eva, Muhammad, Madiha A., Horswell, Stuart, Gerlinger, Marco, Varela, Ignacio, Jones, David, Marshall, John, Voet, Thierry, Van Loo, Peter, Rassl, Doris M., Rintoul, Robert C., Janes, Sam M., Lee, Siow-Ming, Forster, Martin, Ahmad, Tanya, Lawrence, David, Falzon, Mary, Capitanio, Arrigo, Harkins, Timothy T., Lee, Clarence C., Tom, Warren, Teefe, Enock, Chen, Shann-Ching, Begum, Sharmin, Rabinowitz, Adam, Phillimore, Benjamin, Spencer-Dene, Bradley, Stamp, Gordon, Szallasi, Zoltan, Matthews, Nik, Stewart, Aengus, Campbell, Peter, and Swanton, Charles

Published
2014

16. Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer

Author

Wagner, Steve, Vlachogiannis, Georgios, De Haven Brandon, Alexis, Valenti, Melanie, Box, Gary, Jenkins, Liam, Mancusi, Caterina, Self, Annette, Manodoro, Floriana, Assiotis, Ioannis, Robinson, Penny, Chauhan, Ritika, Rust, Alistair G., Matthews, Nik, Eason, Kate, Khan, Khurum, Starling, Naureen, Cunningham, David, Sadanandam, Anguraj, Isacke, Clare M., Kirkin, Vladimir, Valeri, Nicola, and Whittaker, Steven R.

Published
2019
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17. Additional file 3 of Accumulation of copy number alterations and clinical progression across advanced prostate cancer

Author

Grist, Emily, Friedrich, Stefanie, Brawley, Christopher, Mendes, Larissa, Parry, Marina, Ali, Adnan, Haran, Aine, Hoyle, Alex, Gilson, Claire, Lall, Sharanpreet, Zakka, Leila, Bautista, Carla, Landless, Alex, Nowakowska, Karolina, Wingate, Anna, Wetterskog, Daniel, Hasan, A. M. Mahedi, Akato, Nafisah B., Richmond, Malissa, Ishaq, Sofeya, Matthews, Nik, Hamid, Anis A., Sweeney, Christopher J., Sydes, Matthew R., Berney, Daniel M., Lise, Stefano, Parmar, Mahesh K. B., Clarke, Noel W., James, Nicholas D., Cremaschi, Paolo, Brown, Louise C., and Attard, Gerhardt

Abstract

Additional file 3. Contains supplemental methods-full list of STAMPEDE trial eligibility criteria and criteria for inclusion in the CN-300 cohort.

Published
2022
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18. Additional file 5 of Accumulation of copy number alterations and clinical progression across advanced prostate cancer

Author

Grist, Emily, Friedrich, Stefanie, Brawley, Christopher, Mendes, Larissa, Parry, Marina, Ali, Adnan, Haran, Aine, Hoyle, Alex, Gilson, Claire, Lall, Sharanpreet, Zakka, Leila, Bautista, Carla, Landless, Alex, Nowakowska, Karolina, Wingate, Anna, Wetterskog, Daniel, Hasan, A. M. Mahedi, Akato, Nafisah B., Richmond, Malissa, Ishaq, Sofeya, Matthews, Nik, Hamid, Anis A., Sweeney, Christopher J., Sydes, Matthew R., Berney, Daniel M., Lise, Stefano, Parmar, Mahesh K. B., Clarke, Noel W., James, Nicholas D., Cremaschi, Paolo, Brown, Louise C., and Attard, Gerhardt

Abstract

Additional file 5. List of STAMPEDE investigators.

Published
2022
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19. Additional file 1 of Accumulation of copy number alterations and clinical progression across advanced prostate cancer

Author

Grist, Emily, Friedrich, Stefanie, Brawley, Christopher, Mendes, Larissa, Parry, Marina, Ali, Adnan, Haran, Aine, Hoyle, Alex, Gilson, Claire, Lall, Sharanpreet, Zakka, Leila, Bautista, Carla, Landless, Alex, Nowakowska, Karolina, Wingate, Anna, Wetterskog, Daniel, Hasan, A. M. Mahedi, Akato, Nafisah B., Richmond, Malissa, Ishaq, Sofeya, Matthews, Nik, Hamid, Anis A., Sweeney, Christopher J., Sydes, Matthew R., Berney, Daniel M., Lise, Stefano, Parmar, Mahesh K. B., Clarke, Noel W., James, Nicholas D., Cremaschi, Paolo, Brown, Louise C., and Attard, Gerhardt

Abstract

Additional file 1. Contains supplemental figures 1-12.

Published
2022
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20. Additional file 2 of Accumulation of copy number alterations and clinical progression across advanced prostate cancer

Author

Grist, Emily, Friedrich, Stefanie, Brawley, Christopher, Mendes, Larissa, Parry, Marina, Ali, Adnan, Haran, Aine, Hoyle, Alex, Gilson, Claire, Lall, Sharanpreet, Zakka, Leila, Bautista, Carla, Landless, Alex, Nowakowska, Karolina, Wingate, Anna, Wetterskog, Daniel, Hasan, A. M. Mahedi, Akato, Nafisah B., Richmond, Malissa, Ishaq, Sofeya, Matthews, Nik, Hamid, Anis A., Sweeney, Christopher J., Sydes, Matthew R., Berney, Daniel M., Lise, Stefano, Parmar, Mahesh K. B., Clarke, Noel W., James, Nicholas D., Cremaschi, Paolo, Brown, Louise C., and Attard, Gerhardt

Abstract

Additional file 2: Table S1. STAMPEDE trial sites contributing patients to the CN-300 cohort. Table S2. Cohort characteristics of the CN-300 biomarker cohort compared to the full trial comparison group. Table S3. Survival at 4 years follow-up for different metastatic states (Kaplan-Meier estimates). Table S4. Number of events within the CN-300 cohort within trial endpoints. Table S5. Summary of estimated association between copy number burden and hazard of outcome from univariable and multivariable survival modelling. Table S6. Summary of estimated association between copy number burden and hazard of outcome from multivariable survival models, including interaction with metastatic status.

Published
2022
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21. HMGA2 functions as a competing endogenous RNA to promote lung cancer progression

Author

Kumar, Madhu S., Armenteros-Monterroso, Elena, East, Philip, Chakravorty, Probir, Matthews, Nik, Winslow, Monte M., and Downward, Julian

Subjects
RNA sequencing -- Methods, Gene targeting -- Methods, Lung cancer, Non-small cell -- Development and progression -- Genetic aspects, Genetic transcription -- Identification and classification, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Non-small-cell lung cancer (NSCLC) is the most prevalent histological cancer subtype worldwide (1). As the majority of patients present with invasive, metastatic disease (2), it is vital to understand the [...]

Published
2014
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22. Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Author

Abbosh, Christopher, Birkbak, Nicolai J., Wilson, Gareth A., Jamal-Hanjani, Mariam, Constantin, Tudor, Salari, Raheleh, Le Quesne, John, Moore, David A., Veeriah, Selvaraju, Rosenthal, Rachel, Marafioti, Teresa, Kirkizlar, Eser, Watkins, Thomas B. K., McGranahan, Nicholas, Ward, Sophia, Martinson, Luke, Riley, Joan, Fraioli, Francesco, Al Bakir, Maise, Grnroos, Eva, Zambrana, Francisco, Endozo, Raymondo, Bi, Wenya Linda, Fennessy, Fiona M., Sponer, Nicole, Johnson, Diana, Laycock, Joanne, Shafi, Seema, Czyzewska-Khan, Justyna, Rowan, Andrew, Chambers, Tim, Matthews, Nik, Turajlic, Samra, Hiley, Crispin, Lee, Siow Ming, Forster, Martin D., Ahmad, Tanya, Falzon, Mary, Borg, Elaine, Lawrence, David, Hayward, Martin, Kolvekar, Shyam, Panagiotopoulos, Nikolaos, Janes, Sam M., Thakrar, Ricky, Ahmed, Asia, Blackhall, Fiona, Summers, Yvonne, Hafez, Dina, Naik, Ashwini, Ganguly, Apratim, Kareht, Stephanie, Shah, Rajesh, Joseph, Leena, Quinn, Anne Marie, Crosbie, Phil A., Naidu, Babu, Middleton, Gary, Langman, Gerald, Trotter, Simon, Nicolson, Marianne, Remmen, Hardy, Kerr, Keith, Chetty, Mahendran, Gomersall, Lesley, Fennell, Dean A., Nakas, Apostolos, Rathinam, Sridhar, Anand, Girija, Khan, Sajid, Russell, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-Sellers, Melanie, Prakash, Vineet, Lester, Jason F., Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Oukrif, Dahmane, Akarca, Ayse U., Hartley, John A., Lowe, Helen L., Lock, Sara, Iles, Natasha, Bell, Harriet, Ngai, Yenting, Elgar, Greg, Szallasi, Zoltan, Schwarz, Roland F., Herrero, Javier, Stewart, Aengus, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Lin, C. Jimmy, Rabinowitz, Matthew, Aerts, Hugo J. W. L., Hackshaw, Allan, Shaw, Jacqui A., Zimmermann, Bernhard G., and Swanton, Charles

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Christopher Abbosh; Nicolai J. Birkbak; Gareth A. Wilson; Mariam Jamal-Hanjani; Tudor Constantin; Raheleh Salari; John Le Quesne; David A. Moore; Selvaraju Veeriah; Rachel Rosenthal; Teresa Marafioti; Eser Kirkizlar; Thomas [...]

Published
2018
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24. Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell Carcinoma

Author

Khalique, Saira, primary, Nash, Sarah, additional, Mansfield, David, additional, Wampfler, Julian, additional, Attygale, Ayoma, additional, Vroobel, Katherine, additional, Kemp, Harriet, additional, Buus, Richard, additional, Cottom, Hannah, additional, Roxanis, Ioannis, additional, Jones, Thomas, additional, von Loga, Katharina, additional, Begum, Dipa, additional, Guppy, Naomi, additional, Ramagiri, Pradeep, additional, Fenwick, Kerry, additional, Matthews, Nik, additional, Hubank, Michael, additional, Lord, Christopher, additional, Haider, Syed, additional, Melcher, Alan, additional, Banerjee, Susana, additional, and Natrajan, Rachael, additional

Published
2021
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25. Abstract 1960: Mechanisms of therapeutic synergy between pattern recognition response agonists and cdk4 inhibitors

Author

Roulstone, Victoria, primary, Kyula, Joan, additional, Elliot, Richard, additional, Lord, Christopher J., additional, Matthews, Nik, additional, Jennings, Vicki, additional, Whittock, Harriet, additional, Mansfield, David, additional, Choudhary, Jyoti, additional, Wright, James, additional, Yu, Lu, additional, Melcher, Alan, additional, Vile, Richard, additional, Coffey, Matt, additional, McLaughlin, Martin, additional, and Harrington, Kevin, additional

Published
2021
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26. LUNG CANCER EVOLUTION: Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

Author

de Bruin, Elza C., McGranahan, Nicholas, Mitter, Richard, Salm, Max, Wedge, David C., Yates, Lucy, Jamal-Hanjani, Mariam, Shafi, Seema, Murugaesu, Nirupa, Rowan, Andrew J., Grönroos, Eva, Muhammad, Madiha A., Horswell, Stuart, Gerlinger, Marco, Varela, Ignacio, Jones, David, Marshall, John, Voet, Thierry, Van Loo, Peter, Rassl, Doris M., Rintoul, Robert C., Janes, Sam M., Lee, Siow-Ming, Forster, Martin, Ahmad, Tanya, Lawrence, David, Falzon, Mary, Capitanio, Arrigo, Harkins, Timothy T., Lee, Clarence C., Tom, Warren, Teefe, Enock, Chen, Shann-Ching, Begum, Sharmin, Rabinowitz, Adam, Phillimore, Benjamin, Spencer-Dene, Bradley, Stamp, Gordon, Szallasi, Zoltan, Matthews, Nik, Stewart, Aengus, Campbell, Peter, and Swanton, Charles

Published
2014
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27. Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer

Author

Wagner, Steve, Vlachogiannis, Georgios, De Haven Brandon, Alexis, Valenti, Melanie, Box, Gary, Jenkins, Liam, Mancusi, Caterina, Self, Annette, Manodoro, Floriana, Assiotis, Ioannis, Robinson, Penny, Chauhan, Ritika, Rust, Alistair G., Matthews, Nik, Eason, Kate, Khan, Khurum, Starling, Naureen, Cunningham, David, Sadanandam, Anguraj, Isacke, Clare M., Kirkin, Vladimir, Valeri, Nicola, and Whittaker, Steven R.

Subjects
Pyridones, Correction, Drug Synergism, Azepines, Pyrimidinones, Triazoles, Xenograft Model Antitumor Assays, Colorectal cancer, Article, Gene Expression Regulation, Neoplastic, Organoids, Proto-Oncogene Proteins p21(ras), Mice, Drug Resistance, Neoplasm, Cell Line, Tumor, Mutation, Cancer genomics, Animals, Humans, Female, Gene Regulatory Networks, Interferons, Colorectal Neoplasms
Abstract

Despite showing clinical activity in BRAF-mutant melanoma, the MEK inhibitor (MEKi) trametinib has failed to show clinical benefit in KRAS-mutant colorectal cancer. To identify mechanisms of resistance to MEKi, we employed a pharmacogenomic analysis of MEKi-sensitive versus MEKi-resistant colorectal cancer cell lines. Strikingly, interferon- and inflammatory-related gene sets were enriched in cell lines exhibiting intrinsic and acquired resistance to MEK inhibition. The bromodomain inhibitor JQ1 suppressed interferon-stimulated gene (ISG) expression and in combination with MEK inhibitors displayed synergistic effects and induced apoptosis in MEKi-resistant colorectal cancer cell lines. ISG expression was confirmed in patient-derived organoid models, which displayed resistance to trametinib and were resensitized by JQ1 co-treatment. In in vivo models of colorectal cancer, combination treatment significantly suppressed tumor growth. Our findings provide a novel explanation for the limited response to MEK inhibitors in KRAS-mutant colorectal cancer, known for its inflammatory nature. Moreover, the high expression of ISGs was associated with significantly reduced survival of colorectal cancer patients. Excitingly, we have identified novel therapeutic opportunities to overcome intrinsic and acquired resistance to MEK inhibition in colorectal cancer.

Published
2018

28. The Mutational Concordance of Fixed Formalin Paraffin Embedded and Fresh Frozen Gastro-Oesophageal Tumours Using Whole Exome Sequencing

Author

Chong, Irene Y., primary, Starling, Naureen, additional, Rust, Alistair, additional, Alexander, John, additional, Aronson, Lauren, additional, Llorca-Cardenosa, Marta, additional, Chauhan, Ritika, additional, Chaudry, Asif, additional, Kumar, Sacheen, additional, Fenwick, Kerry, additional, Assiotis, Ioannis, additional, Matthews, Nik, additional, Begum, Ruwaida, additional, Wotherspoon, Andrew, additional, Terlizzo, Monica, additional, Watkins, David, additional, Chau, Ian, additional, Lord, Christopher J., additional, Haider, Syed, additional, Rao, Sheela, additional, and Cunningham, David, additional

Published
2021
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29. Abstract PR06: Stabilising selection causes grossly altered but stable karyotypes in metastatic colorectal cancer

Author

Nowinski, Salpie, primary, Cross, William, additional, Mossner, Maximilian, additional, Cresswell, George, additional, Banerjee, Abhirup, additional, Williams, Marc, additional, Gay, Laura, additional, Baker, Ann-Marie, additional, Lu, Binxgin, additional, Kimberley, Christopher, additional, Davis, Hayley, additional, Matthews, Nik, additional, Lacle, Miangela M., additional, Tomlinson, Ian P.M., additional, Jansen, Marnix, additional, Watson, Alan, additional, Barnes, Chris, additional, Wright, Nicholas A., additional, Bridgewater, John, additional, Rodriguez-Justo, Manuel, additional, Kocher, Hemant, additional, Leedham, Simon J., additional, Sottoriva, Andrea, additional, and Graham, Trevor A., additional

Published
2020
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31. Next Generation Sequencing Assay for Detection of Circulating HPV DNA (cHPV-DNA) in Patients Undergoing Radical (Chemo)Radiotherapy in Anal Squamous Cell Carcinoma (ASCC)

Author

Lee, Jen Y., primary, Cutts, Rosalind J., additional, White, Ingrid, additional, Augustin, Yolanda, additional, Garcia-Murillas, Isaac, additional, Fenwick, Kerry, additional, Matthews, Nik, additional, Turner, Nicholas C., additional, Harrington, Kevin, additional, Gilbert, Duncan C., additional, and Bhide, Shreerang, additional

Published
2020
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32. Stabilising selection causes grossly altered but stable karyotypes in metastatic colorectal cancer

Author

Cross, William, primary, Mossner, Maximilian, additional, Nowinski, Salpie, additional, Cresswell, George, additional, Banerjee, Abhirup, additional, Williams, Marc, additional, Gay, Laura, additional, Baker, Ann-Marie, additional, Kimberley, Christopher, additional, Davis, Hayley, additional, Martinez, Pierre, additional, Traki, Maria, additional, Walther, Viola, additional, Smith, Kane, additional, Caravagna, Giulio, additional, Amarasingam, Sasikumar, additional, Elia, George, additional, Berner, Alison, additional, Choi, Ryan Changho, additional, Ramagiri, Pradeep, additional, Chauhan, Ritika, additional, Matthews, Nik, additional, Murphy, Jamie, additional, Antoniou, Anthony, additional, Clark, Susan, additional, Aleong, Jo-Anne Chin, additional, Domingo, Enric, additional, Spiteri, Inmaculada, additional, McDonald, Stuart AC, additional, Shibata, Darryl, additional, Lacle, Miangela M, additional, Wang, Lai Mun, additional, Moorghen, Morgan, additional, Tomlinson, Ian PM, additional, Novelli, Marco, additional, Jansen, Marnix, additional, Watson, Alan, additional, Wright, Nicholas A, additional, Bridgewater, John, additional, Rodriguez-Justo, Manuel, additional, Kocher, Hemant, additional, Leedham, Simon J, additional, Sottoriva, Andrea, additional, and Graham, Trevor A, additional

Published
2020
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33. Detecting and Tracking Circulating Tumour DNA Copy Number Profiles during First Line Chemotherapy in Oesophagogastric Adenocarcinoma

Author

Davidson, Michael, Barber, Louise J., Woolston, Andrew, Cafferkey, Catherine, Mansukhani, Sonia, Griffiths, Beatrice, Moorcraft, Sing-Yu, Rana, Isma, Begum, Ruwaida, Assiotis, Ioannis, Matthews, Nik, Rao, Sheela, Watkins, David, Chau, Ian, Cunningham, David, Starling, Naureen, and Gerlinger, Marco

Subjects
somatic copy number aberration, liquid biopsy, circulating tumour DNA, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Article, oesophagogastric adenocarcinoma
Abstract

DNA somatic copy number aberrations (SCNAs) are key drivers in oesophagogastric adenocarcinoma (OGA). Whether minimally invasive SCNA analysis of circulating tumour (ct)DNA can predict treatment outcomes and reveal how SCNAs evolve during chemotherapy is unknown. We investigated this by low-coverage whole genome sequencing (lcWGS) of ctDNA from 30 patients with advanced OGA prior to first-line chemotherapy and on progression. SCNA profiles were detectable pretreatment in 23/30 (76.7%) patients. The presence of liver metastases, primary tumour in situ, or of oesophageal or junctional tumour location predicted for a high ctDNA fraction. A low ctDNA concentration associated with significantly longer overall survival. Neither chromosomal instability metrics nor ploidy correlated with chemotherapy outcome. Chromosome 2q and 8p gains before treatment were associated with chemotherapy responses. lcWGS identified all amplifications found by prior targeted tumour tissue sequencing in cases with detectable ctDNA as well as finding additional changes. SCNA profiles changed during chemotherapy, indicating that cancer cell populations evolved during treatment, however, no recurrent SCNA changes were acquired at progression. Tracking the evolution of OGA cancer cell populations in ctDNA is feasible during chemotherapy. The observation of genetic evolution warrants investigation in larger series and with higher resolution techniques to reveal potential genetic predictors of response and drivers of chemotherapy resistance. The presence of liver metastasis is a potential biomarker for the selection of patients with high ctDNA content for such studies.

Published
2019
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34. Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Author

Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O'Brien, Tim, Lopez, Jose I, Watkins, Thomas BK, Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J, Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C, Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Grönroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F, Silva, Bruno, Herrero, Javier, Luscombe, Nick M, Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J, Wilson, Gareth A, Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szallasi, Zoltan, Gore, Martin, McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, Swanton, Charles, TRACERx Renal Consortium, Mitchell, Thomas [0000-0003-0761-9503], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, intratumor heterogeneity, branched evolution, linear evolution, renal cell cancer, Chromosomes, Clonal Evolution, Evolution, Molecular, Genetic Heterogeneity, deterministic evolution, Biomarkers, Tumor, metastasis, Humans, Longitudinal Studies, Prospective Studies, Neoplasm Metastasis, Carcinoma, Renal Cell, Alleles, Phylogeny, Aged, Aged, 80 and over, cancer evolution, Models, Statistical, tumor diversity, Genetic Variation, punctuated evolution, Sequence Analysis, DNA, Middle Aged, Prognosis, Kidney Neoplasms, Phenotype, Mutation, Disease Progression, Female, chromosome instability
Abstract

The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that subclonal diversification is associated with known prognostic parameters. By resolving the patterns of driver event ordering, co-occurrence, and mutual exclusivity at clone level, we show the deterministic nature of clonal evolution. ccRCC can be grouped into seven evolutionary subtypes, ranging from tumors characterized by early fixation of multiple mutational and copy number drivers and rapid metastases to highly branched tumors with >10 subclonal drivers and extensive parallel evolution associated with attenuated progression. We identify genetic diversity and chromosomal complexity as determinants of patient outcome. Our insights reconcile the variable clinical behavior of ccRCC and suggest evolutionary potential as a biomarker for both intervention and surveillance.

Published
2018
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35. Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

Author

von Loga, Katharina, primary, Woolston, Andrew, additional, Punta, Marco, additional, Barber, Louise, additional, Griffiths, Beatrice, additional, Semiannikova, Maria, additional, Spain, Georgia, additional, Challoner, Benjamin, additional, Fenwick, Kerry, additional, Simon, Ronald, additional, Marx, Andreas, additional, Sauter, Guido, additional, Lise, Stefano, additional, Matthews, Nik, additional, and Gerlinger, Marco, additional

Published
2019
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36. CEA expression patterns determine response and resistance to the CEA-TCB bispecific immunotherapy antibody in colorectal cancer patient derived organoids.

Author

Gonzalez Exposito, Reyes, primary, Semmianikova, Maria, additional, Griffiths, Beatrice, additional, Khan, Khurum Hayat, additional, Barber, Louise J, additional, Woolston, Andrew, additional, Spain, Georgia, additional, von Loga, Katharina, additional, Swain, Amanda, additional, Thomas, Janet, additional, Bryant, Annette, additional, Mansfield, David, additional, Rao, Sheela, additional, Watkins, David J., additional, Chau, Ian, additional, Starling, Naureen, additional, Matthews, Nik, additional, Wallberg, Fredrik, additional, Cunningham, David, additional, and Gerlinger, Marco, additional

Published
2019
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37. Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Author

Especialidades médico-quirúrgicas, Medikuntza eta kirurgia espezialitateak, Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O'Brien, Tim, López Fernández de Villaverde, José Ignacio, Watkins, Thomas B. K., Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J., Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Archana Sinduri, Fernando, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C., Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Gronroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F., Silva, Bruno, Herrero, Javier, Luscombe, Nick M., Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J., Wilson, Gareth A., Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szállási, Zoltán, Gore, Martin E., McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, Swanton, Charles, Especialidades médico-quirúrgicas, Medikuntza eta kirurgia espezialitateak, Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O'Brien, Tim, López Fernández de Villaverde, José Ignacio, Watkins, Thomas B. K., Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J., Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Archana Sinduri, Fernando, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C., Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Gronroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F., Silva, Bruno, Herrero, Javier, Luscombe, Nick M., Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J., Wilson, Gareth A., Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szállási, Zoltán, Gore, Martin E., McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, and Swanton, Charles

Abstract

The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that subclonal diversification is associated with known prognostic parameters. By resolving the patterns of driver event ordering, co-occurrence, and mutual exclusivity at clone level, we show the deterministic nature of clonal evolution. ccRCC can be grouped into seven evolutionary subtypes, ranging from tumors characterized by early fixation of multiple mutational and copy number drivers and rapid metastases to highly branched tumors with > 10 subclonal drivers and extensive parallel evolution associated with attenuated progression. We identify genetic diversity and chromosomal complexity as determinants of patient outcome. Our insights reconcile the variable clinical behavior of ccRCC and suggest evolutionary potential as a biomarker for both intervention and surveillance.

Published
2018

38. Fc-Optimized Anti-CD25 depletes tumor-infiltrating regulatory T Cells and synergizes with PD-1 Blockade to eradicate established tumors

Author

Arce Vargas, Frederick, Furness, Andrew J.S., Solomon, Isabelle, Joshi, Kroopa, Mekkaoui, Leila, Lesko, Marta H., Miranda Rota, Enrique, Dahan, Rony, Georgiou, Andrew, Sledzinska, Anna, Ben Aissa, Assma, Franz, Dafne, Werner Sunderland, Mariana, Wong, Yien Ning Sophia, Henry, Jake Y., O’Brien, Tim, Nicol, David, Challacombe, Ben, Beers, Stephen A., Turajlic, Samra, Gore, Martin, Larkin, James, Swanton, Charles, Chester, Kerry A., Pule, Martin, Ravetch, Jeffrey V., Marafioti, Teresa, Peggs, Karl S., Quezada, Sergio A., Spain, Lavinia, Wotherspoon, Andrew, Francis, Nicholas, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Soultati, Aspasia, Stares, Mark, Lynch, Joanna, Fotiadis, Nicos, Fernando, Archana, Hazell, Steve, Chandra, Ashish, Pickering, Lisa, Rudman, Sarah, Chowdhury, Simon, Jamal-Hanjani, Mariam, Veeriah, Selvaraju, Shafi, Seema, Czyzewska-Khan, Justyna, Johnson, Diana, Laycock, Joanne, Bosshard-Carter, Leticia, Goh, Gerald, Rosenthal, Rachel, Gorman, Pat, Murugaesu, Nirupa, Hynds, Robert E., Wilson, Gareth, Birkbak, Nicolai J., Watkins, Thomas B.K., McGranahan, Nicholas, Horswell, Stuart, Mitter, Richard, Escudero, Mickael, Stewart, Aengus, Van Loo, Peter, Rowan, Andrew, Xu, Hang, Hiley, Crispin, Abbosh, Christopher, Goldman, Jacki, Stone, Richard Kevin, Denner, Tamara, Matthews, Nik, Elgar, Greg, Ward, Sophia, Biggs, Jennifer, Costa, Marta, Begum, Sharmin, Phillimore, Ben, Chambers, Tim, Nye, Emma, Graca, Sofia, Al Bakir, Maise, Hartley, John A., Lowe, Helen L., Herrero, Javier, Lawrence, David, Hayward, Martin, Panagiotopoulos, Nikolaos, Kolvekar, Shyam, Falzon, Mary, Borg, Elaine, Simeon, Celia, Hector, Gemma, Smith, Amy, Aranda, Marie, Novelli, Marco, Oukrif, Dahmane, Janes, Sam M., Thakrar, Ricky, Forster, Martin, Ahmad, Tanya, Lee, Siow Ming, Papadatos-Pastos, Dionysis, Carnell, Dawn, Mendes, Ruheena, George, Jeremy, Navani, Neal, Ahmed, Asia, Taylor, Magali, Choudhary, Junaid, Summers, Yvonne, Califano, Raffaele, Taylor, Paul, Shah, Rajesh, Krysiak, Piotr, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Evison, Matthew, Crosbie, Phil, Moss, Stuart, Idries, Faiza, Joseph, Leena, Bishop, Paul, Chaturved, Anshuman, Quinn, Anne Marie, Doran, Helen, Leek, Angela, Harrison, Phil, Moore, Katrina, Waddington, Rachael, Novasio, Juliette, Blackhall, Fiona, Rogan, Jane, Smith, Elaine, Dive, Caroline, Tugwood, Jonathan, Brady, Ged, Rothwell, Dominic G., Chemi, Francesca, Pierce, Jackie, Gulati, Sakshi, Naidu, Babu, Langman, Gerald, Trotter, Simon, Bellamy, Mary, Bancroft, Hollie, Kerr, Amy, Kadiri, Salma, Webb, Joanne, Middleton, Gary, Djearaman, Madava, Fennell, Dean, Shaw, Jacqui A., Le Quesne, John, Moore, David, Nakas, Apostolos, Rathinam, Sridhar, Monteiro, William, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Riley, Joan, Primrose, Lindsay, Martinson, Luke, Anand, Girija, Khan, Sajid, Amadi, Anita, Nicolson, Marianne, Kerr, Keith, Palmer, Shirley, Remmen, Hardy, Miller, Joy, Buchan, Keith, Chetty, Mahendran, Gomersall, Lesley, Lester, Jason, Edwards, Alison, Morgan, Fiona, Adams, Haydn, Davies, Helen, Kornaszewska, Malgorzata, Attanoos, Richard, Lock, Sara, Verjee, Azmina, MacKenzie, Mairead, Wilcox, Maggie, Bell, Harriet, Iles, Natasha, Hackshaw, Allan, Ngai, Yenting, Smith, Sean, Gower, Nicole, Ottensmeier, Christian, Chee, Serena, Johnson, Benjamin, Alzetani, Aiman, Shaw, Emily, Lim, Eric, De Sousa, Paulo, Barbosa, Monica Tavares, Bowman, Alex, Jorda, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Cufari, Maria Elena, Ronquillo, John Carlo, Kwayie, Angela, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Buderi, Silviu, Finch, Jonathan, Azcarate, Leire, Chavan, Hema, Green, Sophie, Mashinga, Hillaria, Nicholson, Andrew G., Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Conibear, John, Ezhil, Veni, Ismail, Babikir, Irvin-sellers, Melanie, Prakash, Vineet, Russell, Peter, Light, Teresa, Horey, Tracey, Danson, Sarah, Bury, Jonathan, Edwards, John, Hill, Jennifer, Matthews, Sue, Kitsanta, Yota, Suvarna, Kim, Fisher, Patricia, Keerio, Allah Dino, Shackcloth, Michael, Gosney, John, Postmus, Pieter, Feeney, Sarah, and Asante-Siaw, Julius

Subjects
hemic and immune systems, chemical and pharmacologic phenomena, R1
Abstract

Summary\ud \ud CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25 antibodies were observed to deplete Treg cells in the periphery, upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumor activity previously observed in pre-clinical models. Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors. Combination with anti-programmed cell death protein-1 antibodies promoted complete tumor rejection, demonstrating the relevance of CD25 as a therapeutic target and promising substrate for future combination approaches in immune-oncology.

Published
2017

39. Ultra-Sensitive Mutation Detection and Genome-Wide DNA Copy Number Reconstruction by Error-Corrected Circulating Tumor DNA Sequencing

Author

Mansukhani, Sonia, primary, Barber, Louise J, primary, Kleftogiannis, Dimitrios, primary, Moorcraft, Sing Yu, primary, Davidson, Michael, primary, Woolston, Andrew, primary, Proszek, Paula Zuzanna, primary, Griffiths, Beatrice, primary, Fenwick, Kerry, primary, Herman, Bram, primary, Matthews, Nik, primary, O'Leary, Ben, primary, Hulkki, Sanna, primary, Gonzalez De Castro, David, primary, Patel, Anisha, primary, Wotherspoon, Andrew, primary, Okachi, Aleruchi, primary, Rana, Isma, primary, Begum, Ruwaida, primary, Davies, Matthew N, primary, Powles, Thomas, primary, von Loga, Katharina, primary, Hubank, Michael, primary, Turner, Nick, primary, Watkins, David, primary, Chau, Ian, primary, Cunningham, David, primary, Lise, Stefano, primary, Starling, Naureen, primary, and Gerlinger, Marco, primary

Published
2018
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40. Abstract LB-094: Suppression of inflammatory gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer

Author

Wagner, Steve, primary, Vlachogiannis, George, additional, Brandon, Alexis de Haven, additional, Valenti, Melanie, additional, Box, Gary, additional, Jenkins, Liam, additional, Mancusi, Caterina, additional, Self, Annette, additional, Chauhan, Ritika, additional, Rust, Alistair, additional, Matthews, Nik, additional, Eason, Kate, additional, Sadanandam, Anguraj, additional, Isacke, Clare, additional, Kirkin, Vladimir, additional, Valeri, Nicola, additional, and Whittaker, Steven R., additional

Published
2018
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41. Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Author

Turajlic, Samra, primary, Xu, Hang, additional, Litchfield, Kevin, additional, Rowan, Andrew, additional, Horswell, Stuart, additional, Chambers, Tim, additional, O’Brien, Tim, additional, Lopez, Jose I., additional, Watkins, Thomas B.K., additional, Nicol, David, additional, Stares, Mark, additional, Challacombe, Ben, additional, Hazell, Steve, additional, Chandra, Ashish, additional, Mitchell, Thomas J., additional, Au, Lewis, additional, Eichler-Jonsson, Claudia, additional, Jabbar, Faiz, additional, Soultati, Aspasia, additional, Chowdhury, Simon, additional, Rudman, Sarah, additional, Lynch, Joanna, additional, Fernando, Archana, additional, Stamp, Gordon, additional, Nye, Emma, additional, Stewart, Aengus, additional, Xing, Wei, additional, Smith, Jonathan C., additional, Escudero, Mickael, additional, Huffman, Adam, additional, Matthews, Nik, additional, Elgar, Greg, additional, Phillimore, Ben, additional, Costa, Marta, additional, Begum, Sharmin, additional, Ward, Sophia, additional, Salm, Max, additional, Boeing, Stefan, additional, Fisher, Rosalie, additional, Spain, Lavinia, additional, Navas, Carolina, additional, Grönroos, Eva, additional, Hobor, Sebastijan, additional, Sharma, Sarkhara, additional, Aurangzeb, Ismaeel, additional, Lall, Sharanpreet, additional, Polson, Alexander, additional, Varia, Mary, additional, Horsfield, Catherine, additional, Fotiadis, Nicos, additional, Pickering, Lisa, additional, Schwarz, Roland F., additional, Silva, Bruno, additional, Herrero, Javier, additional, Luscombe, Nick M., additional, Jamal-Hanjani, Mariam, additional, Rosenthal, Rachel, additional, Birkbak, Nicolai J., additional, Wilson, Gareth A., additional, Pipek, Orsolya, additional, Ribli, Dezso, additional, Krzystanek, Marcin, additional, Csabai, Istvan, additional, Szallasi, Zoltan, additional, Gore, Martin, additional, McGranahan, Nicholas, additional, Van Loo, Peter, additional, Campbell, Peter, additional, Larkin, James, additional, and Swanton, Charles, additional

Published
2018
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42. Erratum: Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Author

Abbosh, Christopher, primary, Birkbak, Nicolai J., additional, Wilson, Gareth A., additional, Jamal-Hanjani, Mariam, additional, Constantin, Tudor, additional, Salari, Raheleh, additional, Le Quesne, John, additional, Moore, David A., additional, Veeriah, Selvaraju, additional, Rosenthal, Rachel, additional, Marafioti, Teresa, additional, Kirkizlar, Eser, additional, Watkins, Thomas B. K., additional, McGranahan, Nicholas, additional, Ward, Sophia, additional, Martinson, Luke, additional, Riley, Joan, additional, Fraioli, Francesco, additional, Al Bakir, Maise, additional, Grönroos, Eva, additional, Zambrana, Francisco, additional, Endozo, Raymondo, additional, Bi, Wenya Linda, additional, Fennessy, Fiona M., additional, Sponer, Nicole, additional, Johnson, Diana, additional, Laycock, Joanne, additional, Shafi, Seema, additional, Czyzewska-Khan, Justyna, additional, Rowan, Andrew, additional, Chambers, Tim, additional, Matthews, Nik, additional, Turajlic, Samra, additional, Hiley, Crispin, additional, Lee, Siow Ming, additional, Forster, Martin D., additional, Ahmad, Tanya, additional, Falzon, Mary, additional, Borg, Elaine, additional, Lawrence, David, additional, Hayward, Martin, additional, Kolvekar, Shyam, additional, Panagiotopoulos, Nikolaos, additional, Janes, Sam M., additional, Thakrar, Ricky, additional, Ahmed, Asia, additional, Blackhall, Fiona, additional, Summers, Yvonne, additional, Hafez, Dina, additional, Naik, Ashwini, additional, Ganguly, Apratim, additional, Kareht, Stephanie, additional, Shah, Rajesh, additional, Joseph, Leena, additional, Quinn, Anne Marie, additional, Crosbie, Phil A., additional, Naidu, Babu, additional, Middleton, Gary, additional, Langman, Gerald, additional, Trotter, Simon, additional, Nicolson, Marianne, additional, Remmen, Hardy, additional, Kerr, Keith, additional, Chetty, Mahendran, additional, Gomersall, Lesley, additional, Fennell, Dean A., additional, Nakas, Apostolos, additional, Rathinam, Sridhar, additional, Anand, Girija, additional, Khan, Sajid, additional, Russell, Peter, additional, Ezhil, Veni, additional, Ismail, Babikir, additional, Irvin-Sellers, Melanie, additional, Prakash, Vineet, additional, Lester, Jason F., additional, Kornaszewska, Malgorzata, additional, Attanoos, Richard, additional, Adams, Haydn, additional, Davies, Helen, additional, Oukrif, Dahmane, additional, Akarca, Ayse U., additional, Hartley, John A., additional, Lowe, Helen L., additional, Lock, Sara, additional, Iles, Natasha, additional, Bell, Harriet, additional, Ngai, Yenting, additional, Elgar, Greg, additional, Szallasi, Zoltan, additional, Schwarz, Roland F., additional, Herrero, Javier, additional, Stewart, Aengus, additional, Quezada, Sergio A., additional, Peggs, Karl S., additional, Van Loo, Peter, additional, Dive, Caroline, additional, Lin, C. Jimmy, additional, Rabinowitz, Matthew, additional, Aerts, Hugo J. W. L., additional, Hackshaw, Allan, additional, Shaw, Jacqui A., additional, Zimmermann, Bernhard G., additional, and Swanton, Charles, additional

Published
2017
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43. Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumour DNA sequencing

Author

Mansukhani, Sonia, primary, Barber, Louise J., additional, Moorcraft, Sing Yu, additional, Davidson, Michael, additional, Woolston, Andrew, additional, Griffiths, Beatrice, additional, Fenwick, Kerry, additional, Herman, Bram, additional, Matthews, Nik, additional, O’Leary, Ben, additional, Hulkki, Sanna, additional, De Castro, David Gonzalez, additional, Hubank, Michael, additional, Patel, Anisha, additional, Wotherspoon, Andrew, additional, Okachi, Aleruchi, additional, Rana, Isma, additional, Begum, Ruwaida, additional, Davies, Matthew, additional, Powles, Thomas, additional, von Loga, Katharina, additional, Turner, Nick, additional, Watkins, David, additional, Chau, Ian, additional, Cunningham, David, additional, Starling, Naureen, additional, and Gerlinger, Marco, additional

Published
2017
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44. Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Author

McGranahan, Nicholas, primary, Rosenthal, Rachel, additional, Hiley, Crispin T., additional, Rowan, Andrew J., additional, Watkins, Thomas B.K., additional, Wilson, Gareth A., additional, Birkbak, Nicolai J., additional, Veeriah, Selvaraju, additional, Van Loo, Peter, additional, Herrero, Javier, additional, Swanton, Charles, additional, Jamal-Hanjani, Mariam, additional, Shafi, Seema, additional, Czyzewska-Khan, Justyna, additional, Johnson, Diana, additional, Laycock, Joanne, additional, Bosshard-Carter, Leticia, additional, Gorman, Pat, additional, Hynds, Robert E., additional, Wilson, Gareth, additional, McGranahan, Nicholas, additional, Horswell, Stuart, additional, Mitter, Richard, additional, Escudero, Mickael, additional, Stewart, Aengus, additional, Rowan, Andrew, additional, Xu, Hang, additional, Turajlic, Samra, additional, Hiley, Crispin, additional, Abbosh, Christopher, additional, Goldman, Jacki, additional, Stone, Richard Kevin, additional, Denner, Tamara, additional, Matthews, Nik, additional, Elgar, Greg, additional, Ward, Sophia, additional, Costa, Marta, additional, Begum, Sharmin, additional, Phillimore, Ben, additional, Chambers, Tim, additional, Nye, Emma, additional, Graca, Sofia, additional, Al Bakir, Maise, additional, Joshi, Kroopa, additional, Furness, Andrew, additional, Ben Aissa, Assma, additional, Wong, Yien Ning Sophia, additional, Georgiou, Andy, additional, Quezada, Sergio, additional, Hartley, John A., additional, Lowe, Helen L., additional, Lawrence, David, additional, Hayward, Martin, additional, Panagiotopoulos, Nikolaos, additional, Kolvekar, Shyam, additional, Falzon, Mary, additional, Borg, Elaine, additional, Marafioti, Teresa, additional, Simeon, Celia, additional, Hector, Gemma, additional, Smith, Amy, additional, Aranda, Marie, additional, Novelli, Marco, additional, Oukrif, Dahmane, additional, Janes, Sam M., additional, Thakrar, Ricky, additional, Forster, Martin, additional, Ahmad, Tanya, additional, Lee, Siow Ming, additional, Papadatos-Pastos, Dionysis, additional, Carnell, Dawn, additional, Mendes, Ruheena, additional, George, Jeremy, additional, Navani, Neal, additional, Ahmed, Asia, additional, Taylor, Magali, additional, Choudhary, Junaid, additional, Summers, Yvonne, additional, Califano, Raffaele, additional, Taylor, Paul, additional, Shah, Rajesh, additional, Krysiak, Piotr, additional, Rammohan, Kendadai, additional, Fontaine, Eustace, additional, Booton, Richard, additional, Evison, Matthew, additional, Crosbie, Phil, additional, Moss, Stuart, additional, Idries, Faiza, additional, Joseph, Leena, additional, Bishop, Paul, additional, Chaturved, Anshuman, additional, Quinn, Anne Marie, additional, Doran, Helen, additional, Leek, Angela, additional, Harrison, Phil, additional, Moore, Katrina, additional, Waddington, Rachael, additional, Novasio, Juliette, additional, Blackhall, Fiona, additional, Rogan, Jane, additional, Smith, Elaine, additional, Dive, Caroline, additional, Tugwood, Jonathan, additional, Brady, Ged, additional, Rothwell, Dominic G., additional, Chemi, Francesca, additional, Pierce, Jackie, additional, Gulati, Sakshi, additional, Naidu, Babu, additional, Langman, Gerald, additional, Trotter, Simon, additional, Bellamy, Mary, additional, Bancroft, Hollie, additional, Kerr, Amy, additional, Kadiri, Salma, additional, Webb, Joanne, additional, Middleton, Gary, additional, Djearaman, Madava, additional, Fennell, Dean, additional, Shaw, Jacqui A., additional, Le Quesne, John, additional, Moore, David, additional, Nakas, Apostolos, additional, Rathinam, Sridhar, additional, Monteiro, William, additional, Marshall, Hilary, additional, Nelson, Louise, additional, Bennett, Jonathan, additional, Riley, Joan, additional, Primrose, Lindsay, additional, Martinson, Luke, additional, Anand, Girija, additional, Khan, Sajid, additional, Amadi, Anita, additional, Nicolson, Marianne, additional, Kerr, Keith, additional, Palmer, Shirley, additional, Remmen, Hardy, additional, Miller, Joy, additional, Buchan, Keith, additional, Chetty, Mahendran, additional, Gomersall, Lesley, additional, Lester, Jason, additional, Edwards, Alison, additional, Morgan, Fiona, additional, Adams, Haydn, additional, Davies, Helen, additional, Kornaszewska, Malgorzata, additional, Attanoos, Richard, additional, Lock, Sara, additional, Verjee, Azmina, additional, MacKenzie, Mairead, additional, Wilcox, Maggie, additional, Bell, Harriet, additional, Hackshaw, Allan, additional, Ngai, Yenting, additional, Smith, Sean, additional, Gower, Nicole, additional, Ottensmeier, Christian, additional, Chee, Serena, additional, Johnson, Benjamin, additional, Alzetani, Aiman, additional, Shaw, Emily, additional, Lim, Eric, additional, De Sousa, Paulo, additional, Barbosa, Monica Tavares, additional, Bowman, Alex, additional, Jordan, Simon, additional, Rice, Alexandra, additional, Raubenheimer, Hilgardt, additional, Proli, Chiara, additional, Cufari, Maria Elena, additional, Ronquillo, John Carlo, additional, Kwayie, Angela, additional, Bhayani, Harshil, additional, Hamilton, Morag, additional, Bakar, Yusura, additional, Mensah, Natalie, additional, Ambrose, Lyn, additional, Devaraj, Anand, additional, Buderi, Silviu, additional, Finch, Jonathan, additional, Azcarate, Leire, additional, Chavan, Hema, additional, Green, Sophie, additional, Mashinga, Hillaria, additional, Nicholson, Andrew G., additional, Lau, Kelvin, additional, Sheaff, Michael, additional, Schmid, Peter, additional, Conibear, John, additional, Ezhil, Veni, additional, Ismail, Babikir, additional, Irvin-sellers, Melanie, additional, Prakash, Vineet, additional, Russell, Peter, additional, Light, Teresa, additional, Horey, Tracey, additional, Danson, Sarah, additional, Bury, Jonathan, additional, Edwards, John, additional, Hill, Jennifer, additional, Matthews, Sue, additional, Kitsanta, Yota, additional, Suvarna, Kim, additional, Fisher, Patricia, additional, Keerio, Allah Dino, additional, Shackcloth, Michael, additional, Gosney, John, additional, Postmus, Pieter, additional, Feeney, Sarah, additional, Asante-Siaw, Julius, additional, Aerts, Hugo J.W.L., additional, Dentro, Stefan, additional, and Dessimoz, Christophe, additional

Published
2017
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45. Tracking the Evolution of Non–Small-Cell Lung Cancer

Author

Jamal-Hanjani, Mariam, primary, Wilson, Gareth A., additional, McGranahan, Nicholas, additional, Birkbak, Nicolai J., additional, Watkins, Thomas B.K., additional, Veeriah, Selvaraju, additional, Shafi, Seema, additional, Johnson, Diana H., additional, Mitter, Richard, additional, Rosenthal, Rachel, additional, Salm, Max, additional, Horswell, Stuart, additional, Escudero, Mickael, additional, Matthews, Nik, additional, Rowan, Andrew, additional, Chambers, Tim, additional, Moore, David A., additional, Turajlic, Samra, additional, Xu, Hang, additional, Lee, Siow-Ming, additional, Forster, Martin D., additional, Ahmad, Tanya, additional, Hiley, Crispin T., additional, Abbosh, Christopher, additional, Falzon, Mary, additional, Borg, Elaine, additional, Marafioti, Teresa, additional, Lawrence, David, additional, Hayward, Martin, additional, Kolvekar, Shyam, additional, Panagiotopoulos, Nikolaos, additional, Janes, Sam M., additional, Thakrar, Ricky, additional, Ahmed, Asia, additional, Blackhall, Fiona, additional, Summers, Yvonne, additional, Shah, Rajesh, additional, Joseph, Leena, additional, Quinn, Anne M., additional, Crosbie, Phil A., additional, Naidu, Babu, additional, Middleton, Gary, additional, Langman, Gerald, additional, Trotter, Simon, additional, Nicolson, Marianne, additional, Remmen, Hardy, additional, Kerr, Keith, additional, Chetty, Mahendran, additional, Gomersall, Lesley, additional, Fennell, Dean A., additional, Nakas, Apostolos, additional, Rathinam, Sridhar, additional, Anand, Girija, additional, Khan, Sajid, additional, Russell, Peter, additional, Ezhil, Veni, additional, Ismail, Babikir, additional, Irvin-Sellers, Melanie, additional, Prakash, Vineet, additional, Lester, Jason F., additional, Kornaszewska, Malgorzata, additional, Attanoos, Richard, additional, Adams, Haydn, additional, Davies, Helen, additional, Dentro, Stefan, additional, Taniere, Philippe, additional, O’Sullivan, Brendan, additional, Lowe, Helen L., additional, Hartley, John A., additional, Iles, Natasha, additional, Bell, Harriet, additional, Ngai, Yenting, additional, Shaw, Jacqui A., additional, Herrero, Javier, additional, Szallasi, Zoltan, additional, Schwarz, Roland F., additional, Stewart, Aengus, additional, Quezada, Sergio A., additional, Le Quesne, John, additional, Van Loo, Peter, additional, Dive, Caroline, additional, Hackshaw, Allan, additional, and Swanton, Charles, additional

Published
2017
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48. iMYC: Proof-of-concept study of ibrutinib in c-MYC and HER2 amplified oesophagogastric carcinoma.

Author

Davidson, Michael, primary, Chong, Irene Yu-Shing, additional, Cunningham, David, additional, Aronson, Lauren, additional, Bryant, Hanna, additional, Begum, Ruwaida, additional, Swansbury, John, additional, Wotherspoon, Andrew, additional, Matthews, Nik, additional, To, Ye Mong, additional, Kalaitzaki, Eleftheria, additional, Yuan, Lina, additional, Watkins, David J., additional, Starling, Naureen, additional, Rao, Sheela, additional, and Chau, Ian, additional

Published
2017
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