Author: "Matthew Clark" - Searchworks@Jio Institute Digital Library Search Results

467 results on '"Matthew Clark"'

1. Mixed debris interaction with obstacle array under extreme flood conditions

Author: Piyali Chowdhury, Indigo‐Jaie Fredericks, Jesus Castaño Alvarez, Matthew Clark, Ravindra Jayaratne, J. J. Wijetunge, Alison Raby, and Paul Taylor
Subjects: coastal defence, debris flow, flood risk management plans, River protective works. Regulation. Flood control, TC530-537, Disasters and engineering, TA495
Abstract: Abstract This investigation explores the interactions of different shaped debris with an array of obstacles under subcritical flow conditions, representative of a flood associated with a storm surge or tsunami. Panels, blocks and cylinders were used in a flow channel, as analogues for house panels, cars/containers and trees respectively, whilst some tests used a mix of debris. The backwater effect due to the blockage caused by the obstacles was most (least) significant for panels (cylinders). There was some evidence that smaller key log types and higher flow rates led to smaller dams. It was also evident that key logs formed at different depths depending on debris shape; debris shape also determined the vertical shape of the dam. Capture efficiency had a broadly negative (positive) correlation with the Froude number (permeability). Also, from video footage there were examples of the debris moving more quickly through partial dams. Finally, the drag force, deduced from only the water depths and the flow discharge, showed a clear relationship between drag force and Froude number, and a dependency of drag force on debris shape. There are some implications for the layout of building footprints in the inundation zones and the use of large, break‐away panels.
Published: 2024
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2. Second row of eyelashes with lower extremity edema

Author: Lauryn Orsillo, BS, Justice Brown, Sara Yumeen, MD, Oliver Wisco, DO, and Matthew Clark, MD
Subjects: distichiasis, distichiasis syndrome, lymphedema, Dermatology, RL1-803
Published: 2023
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3. Increasing wildfire smoke has limited impacts on national park visitation in the American West

Author: Matthew Clark, Alexander Killion, Matthew A. Williamson, and Vicken Hillis
Subjects: protected areas, recreation, thresholds, wildfire, Ecology, QH540-549.5
Abstract: Abstract Ambient wildfire smoke in the American West has worsened considerably in recent decades, while the number of individuals recreating outdoors has simultaneously surged. Wildfire smoke poses a serious risk to human health, especially during long periods of exposure and during exercise. As such, evaluating whether people modify recreation in response to smoke is important to understanding the public health implications of these trends. Here we aggregate data on black carbon, a major component of wildfire smoke, and recreational visitation in 32 US national parks from 1980 to 2019 to examine how visitors respond to wildfire smoke. We hypothesize that visitor response may exhibit a threshold effect where ambient smoke reduces visitation after a critical level, but not before. We develop a series of breakpoint models to test this hypothesis. The results of these models are mixed, but overall show little to no effect of ambient smoke on visitation to the 32 parks tested, even when allowing for critical thresholds at the extreme upper ranges of smoke exposure. This indicates that wildfire smoke does not greatly alter park attendance. This finding suggests that management actions to protect visitor health during smoke events may be warranted.
Published: 2023
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4. Using terrestrial laser scanning to evaluate non-destructive aboveground biomass allometries in diverse Northern California forests

Author: Paris Krause, Brieanne Forbes, Alexander Barajas-Ritchie, Matthew Clark, Mathias Disney, Phil Wilkes, and Lisa Patrick Bentley
Subjects: terrestrial laser scanning (TLS), tree aboveground biomass, allometric equations, Quercus agrifolia, Quercus garryana, Sequoia sempervirens, Geophysics. Cosmic physics, QC801-809, Meteorology. Climatology, QC851-999
Abstract: A crucial part of carbon accounting is quantifying a tree’s aboveground biomass (AGB) using allometric equations, but species-specific equations are limited because data to inform these equations requires destructive harvesting of many trees which is difficult and time-consuming. Here, we used terrestrial laser scanning (TLS) to non-destructively estimate AGB for 282 trees from 5 species at 3 locations in Northern California using stem and branch volume estimates from quantitative structure models (QSMs) and wood density from the literature. We then compared TLS QSM estimates of AGB with published allometric equations and used TLS-based AGB, diameter at breast height (DBH), and height to derive new species-specific allometric AGB equations for our study species. To validate the use of TLS, we used traditional forestry approaches to collect DBH (n = 550) and height (n = 291) data on individual trees. TLS-based DBH and height were not significantly different from field inventory data (R2 = 0.98 for DBH, R2 = 0.95 for height). Across all species, AGB calculated from TLS QSM volumes were approximately 30% greater than AGB estimates using published Forest Service’s Forest Inventory and Analysis Program equations, and TLS QSM AGB estimates were 10% greater than AGB calculated with existing equations, although this variation was species-dependent. In particular, TLS AGB estimates for Quercus agrifolia and Sequoia sempervirens differed the most from AGB estimates calculated using published equations. New allometric equations created using TLS data with DBH and height performed better than equations that only included DBH and matched most closely with AGB estimates generated from QSMs. Our results support the use of TLS as a method to rapidly estimate height, DBH, and AGB of multiple trees at a plot-level when species are identified and wood density is known. In addition, the creation of new TLS-based non-destructive allometric equations for our 5 study species may have important applications and implications for carbon quantification over larger spatial scales, especially since our equations estimated greater AGB than previous approaches.
Published: 2023
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5. Socio‐ecological interactions promote outbreaks of a harmful invasive plant in an urban landscape

Author: T. Trevor Caughlin, Matthew Clark, Louis W. Jochems, Nick Kolarik, Andrii Zaiats, Cody Hall, Jason M. Winiarski, Breanna F. Powers, Martha M. Brabec, and Kelly Hopping
Subjects: active transportation, human‐mediated dispersal, invasive species, network centrality, road network, spatial demography, Environmental sciences, GE1-350, Ecology, QH540-549.5
Abstract: Abstract Urban landscapes often harbour organisms that harm people and threaten native biodiversity. These landscapes are characterized by differences in socioeconomic context, habitat suitability and patch connectedness. Identifying which spatial differences enable outbreaks of pests, pathogens and invasive species will improve targeted control efforts. We tested hypotheses to explain the distribution and demography of puncturevine Tribulus terrestris, a human‐dispersed invasive plant in Boise, a city in the western United States. We hypothesized an increase in puncturevine infestations near low‐valued properties with a high proportion of bare ground, the species' preferred microhabitat, that are well connected on the urban road network. To test these hypotheses, we collected data on the abundance, emergence and persistence of reproductive plants in transects spanning >100 km of our study city. We then used hierarchical Bayesian models to evaluate the impacts of spatial covariates on puncturevine distribution and demography. Bare ground cover consistently increased abundance, emergence and persistence of puncturevine, indicating the overarching importance of suitable establishment sites for this invasive species. Property value had the strongest impact on puncturevine abundance and was the most important main effect in the model for puncturevine emergence. In both models, lower‐valued properties had a higher risk of puncturevine occurrence. The effects of road network connectivity depended on bare ground cover, with the highest predicted abundance and emergence of puncturevine in patches with low connectivity on the road network and high bare ground cover. Understanding these relationships will require data that can disentangle seed dispersal from establishment limitations. Identifying characteristics of urban patches that promote outbreaks of harmful species will improve the effectiveness and equity of control efforts. The prevalence of puncturevine in lower‐valued properties is cause for concern as the plant impedes bicycle transportation, with the potential for disproportionate impacts on marginalized groups that lack resources to repair punctured tires. Our results add to a growing recognition that low‐connectivity street networks have undesirable outcomes for environmental sustainability. As urban land cover continues to grow worldwide, accounting for interactions between human, natural and built systems will play a crucial role in managing invasive species.
Published: 2023
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6. Modulation of Tumor-Treating Fields by Cerebral Edema from Brain Tumors

Author: Edwin Lok, MS, Matthew Clark, BS, Olivia Liang, Talbia Malik, BS, Sophia Koo, BS, and Eric T. Wong, MD
Subjects: Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Purpose: Cerebral edema is an important component of brain metastasis, and its presence may alter the distribution of tumor-treating fields (TTFields). We therefore performed a computational study to model the extent of this alteration according to various edema conditions associated with the metastasis. Methods and Materials: Postacquisition magnetic resonance imaging data sets were obtained from 2 patients with solitary brain metastases from non-small cell lung cancer. After delineation of various anatomies, a 3-dimensional finite element mesh model was generated and then solved for the distribution of applied electric fields, rate of energy deposition, and current density at the gross tumor volume (GTV), edema, and other cranial structures. Electric field–volume histograms, specific absorption rate–volume histograms, and current density–volume histograms were generated, by which plan quality metrics were derived from and used to evaluate relative differences in field coverage between models under various conditions. Results: Changes in the conductivity of cerebral edema altered the electric fields, rate of energy deposition, and current density at the GTV region. At the cerebral edema region, increasing electric conductivity of the edema only decreased the electric fields and rate of energy deposition while the current density increased. The ratio of edema-to-tumor is also important because the plan quality metrics increased linearly when the edema-to-GTV ratio decreased, and increased vice versa. Furthermore, a conductive necrotic core additionally altered the distribution of TTFields according to the plan quality metrics. Conclusions: Our modeling study demonstrated that cerebral edema alters the distribution of applied TTFields in patients. Personalized treatment planning will need to take into account the modulating effects of cerebral edema on TTFields as well as additional effects from a necrotic core inside the GTV.
Published: 2023
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7. Characterization of Anatomical and Physiological Effects of Variegation Mutation on Grapevine

Author: Jack Olson and Matthew Clark
Subjects: chlorophyll, chloroplast, grape, histology, plant cell, vitis, Plant culture, SB1-1110
Abstract: Variegation is a common trait in plants that characteristically displays white or off-colored plant tissue. In grapevine, leaf variegation is expressed as white and pale green leaf tissue resulting in plants that are stunted in growth and hindered in development. In this study, several experiments were performed to investigate the impact of this mutation has on the anatomy of grape leaves and physiology of the plant. Histological staining of variegated and nonvariegated leaf tissue transections showed alterations to the leaf palisade mesophyll structure that affected leaf tissue width. An assay quantifying leaf pigments was performed to compare chlorophyll and carotenoid concentrations in leaves between variegated and wild-type seedlings, which showed that variegated leaf samples had reduced chlorophyll and carotenoid concentration. Through fluorescence imaging, we determined that photochemical efficiency of photosystem II (PSII) is reduced in variegated seedlings. By growing variegated and wild-type plants under high, medium, and low light intensities that variegated plants exposed to higher light intensity reduces the phenotypic expression of the variegation trait. Also, we found variegated plants to have significant reductions in growth traits such as plant height, leaf number, branch number, and dry weight compared with wild-type phenotype plants. Overall, our experiments revealed the variegation mutation altered normal leaf development causing significant effects to grapevine physiology.
Published: 2021
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8. Genetic Analyses for Leaf Variegation in Hybrid Grape Populations (Vitis spp.) Reveals Two Loci, Lvar1 and Lvar2

Author: Jack Olson, Cheng Zou, Avinash Karn, Bruce Reisch, Lance Cadle-Davidson, Qi Sun, and Matthew Clark
Subjects: breeding, genetics, Plant culture, SB1-1110
Abstract: Variegation in Vitis hybrids was investigated to confirm the inheritance as a single, recessive gene as previously proposed and commonly observed in breeding programs. Variegated leaves have ornamental appeal, but the phenotype is sublethal in some environments. Twenty-nine grape families were characterized for variegation including F1, S1, and S2 populations. The majority segregated 3 wild type (WT):1 variegated and were supported by chi-square tests. Four populations had segregation ratios supporting 15:1 or 1:1 models, and a unique flecking phenotype was identified in a Landot 4511 S1 population that suggested the interaction of two recessive loci. A variegated parent was selfed to produce progeny with no WT offspring and was segregated 0:1. Marker trait associations including bulk segregant analysis (BSA), genome-wide association mapping, and quantitative trait loci (QTL) mapping was used on three populations. On chromosome 14, Lvar1 was identified and mapped to 24.5 to 29.5 Mb and associated closely with rhAmpSeq marker 14_27607541. Lvar2 was associated with rhAmpSeq marker 11_18433819 on chromosome 11 at 12.2 to 18.4 Mb. The identification of two loci and the segregation data in some populations suggest that grape breeding germplasm segregates for two recessive loci. The pedigree records suggest that ‘Frontenac’ inherited one of these loci, and that Landot 4511, an ancestor of many populations tested in this experiment, may carry two loci. A total of 252 candidate genes were identified at these loci, including a key target—adenosine triphosphate (ATP)-dependent zinc metalloprotease FtsH6, involved in photosystem II and similar to the var2 mutant in Arabidopsis. This knowledge can help breeders select for ornamental grapevines or eliminate variegation from their breeding programs.
Published: 2022
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9. High tibial osteotomy: A review of the readability and quality of patientinformation on the internet

Author: Matthew Clark, Ian Colin Baxter, Matthew Hampton, Robert D Sandler, and Andrew Legg
Subjects: health literacy, comprehension, internet based intervention, osteoarthritis, osteotomy, Nutrition. Foods and food supply, TX341-641, Public aspects of medicine, RA1-1270
Abstract: Background: High tibial osteotomy (HTO) is a common procedure performed for unicompartmental knee osteoarthritis (OA). Patients are increasingly using the internet to research surgical procedures to help aid decision making. Our aim was to assess the readability and quality of information available to patients online relating to HTO. Methods: A systematic review of three search engines Google, Bing, and Yahoo using the search terms "high tibial osteotomy" and "tibial osteotomy" separately was performed. The first three pages of results for each search engine were analyzed. Readability was assessed using the Flesch Reading Ease Scale (FRES), Flesch-Kincaid Grade level (FKGL) and the Simple Measure of Gobbledygook formula (SMOG). Quality was assessed with the DISCERN questionnaire, JAMAbenchmarks and the presence of Health on the Net Foundation Code of Conduct (HONCode). Results: Twenty-four webpages were included after duplicates (n=42) and exclusions (n=24).The overall readability was low, with a mean FRES of 53.2 (SD: 9.1), FKGL 10.7 (SD: 1.8),SMOG 10.4 (SD: 1.5). Quality was also low with a mean DISCERN score of 42 (SD: 12.3).None of the webpages fulfilled all of the JAMA benchmarking criteria and only 2/24 (8.3%)webpages possessed HONCode certification. Conclusion: The overall online information available to patient’s considering HTO is of lowreadability and quality. Improving the quality and readability of patient information online willbenefit informed patient decision making before HTO surgery.
Published: 2021
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10. A Multitrait Locus Regulates Sarbecovirus Pathogenesis

Author: Alexandra Schäfer, Sarah R. Leist, Lisa E. Gralinski, David R. Martinez, Emma S. Winkler, Kenichi Okuda, Padraig E. Hawkins, Kendra L. Gully, Rachel L. Graham, D. Trevor Scobey, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Jennifer F. Loome, Emily A. Madden, Elizabeth Anderson, Victoria K. Baxter, Sharon A. Taft-Benz, Mark R. Zweigart, Samantha R. May, Stephanie Dong, Matthew Clark, Darla R. Miller, Rachel M. Lynch, Mark T. Heise, Roland Tisch, Richard C. Boucher, Fernando Pardo Manuel de Villena, Stephanie A. Montgomery, Michael S. Diamond, Martin T. Ferris, and Ralph S. Baric
Subjects: collaborative cross, host response, pathogenesis, SARS-CoV-2, sarbecoviruses, Microbiology, QR1-502
Abstract: ABSTRACT Infectious diseases have shaped the human population genetic structure, and genetic variation influences the susceptibility to many viral diseases. However, a variety of challenges have made the implementation of traditional human Genome-wide Association Studies (GWAS) approaches to study these infectious outcomes challenging. In contrast, mouse models of infectious diseases provide an experimental control and precision, which facilitates analyses and mechanistic studies of the role of genetic variation on infection. Here we use a genetic mapping cross between two distinct Collaborative Cross mouse strains with respect to severe acute respiratory syndrome coronavirus (SARS-CoV) disease outcomes. We find several loci control differential disease outcome for a variety of traits in the context of SARS-CoV infection. Importantly, we identify a locus on mouse chromosome 9 that shows conserved synteny with a human GWAS locus for SARS-CoV-2 severe disease. We follow-up and confirm a role for this locus, and identify two candidate genes, CCR9 and CXCR6, that both play a key role in regulating the severity of SARS-CoV, SARS-CoV-2, and a distantly related bat sarbecovirus disease outcomes. As such we provide a template for using experimental mouse crosses to identify and characterize multitrait loci that regulate pathogenic infectious outcomes across species. IMPORTANCE Host genetic variation is an important determinant that predicts disease outcomes following infection. In the setting of highly pathogenic coronavirus infections genetic determinants underlying host susceptibility and mortality remain unclear. To elucidate the role of host genetic variation on sarbecovirus pathogenesis and disease outcomes, we utilized the Collaborative Cross (CC) mouse genetic reference population as a model to identify susceptibility alleles to SARS-CoV and SARS-CoV-2 infections. Our findings reveal that a multitrait loci found in chromosome 9 is an important regulator of sarbecovirus pathogenesis in mice. Within this locus, we identified and validated CCR9 and CXCR6 as important regulators of host disease outcomes. Specifically, both CCR9 and CXCR6 are protective against severe SARS-CoV, SARS-CoV-2, and SARS-related HKU3 virus disease in mice. This chromosome 9 multitrait locus may be important to help identify genes that regulate coronavirus disease outcomes in humans.
Published: 2022
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11. The Soundscapes to Landscapes Project: Development of a Bioacoustics-Based Monitoring Workflow with Multiple Citizen Scientist Contributions

Author: Rose Snyder, Matthew Clark, Leonardo Salas, Wendy Schackwitz, David Leland, Taylour Stephens, Tiffany Erickson, Teresa Tuffli, Miles Tuffli, and Kathleen Clas
Subjects: citizen science, bioacoustics, birds, biodiversity, audiomoth, engagement, Science
Abstract: Citizen science is an important approach for ecological studies that require county-scale or broader geographic coverage. Here we report on project management, technology, and the variety of roles and levels of engagement of citizen scientists in the Soundscapes to Landscapes project, focused in Sonoma County, California, USA. The project uses low-cost autonomous recording units (ARUs) and bioacoustic analysis to monitor bird diversity and soundscape components at a regional scale. In five years, 259 citizen scientists collectively volunteered 8,390 hours on a range of tasks, with 40% field work and 41% bioacoustic reference data collection, but also including geographic information systems, social media, and data upload. Citizen scientists were a mix of expert collaborators, community volunteers, and undergraduate students. In five distinct field campaigns, 141 citizen scientists deployed recording devices during the breeding bird season at 1,281 sites on public and private lands, and collected 12,431 hours of raw audio recordings. For bioacoustic analysis, we used a custom web-based citizen science interface to produce labeled reference data, through which seven expert citizen scientists and 105 user-level citizen scientists produced 230,066 labeled audio clips. We found that word-of-mouth and personal connections were the best strategies for recruitment and retainment of citizen scientists. Levels of engagement among citizen scientists varied, and community volunteers who participated in more than one task contributed more time to the project overall. Undergraduate students were a valuable citizen scientist group in the project, contributing 48% of the total citizen scientist effort and were particularly important for field work success.
Published: 2022
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12. Comparing Remote Sensing and Field-Based Approaches to Estimate Ladder Fuels and Predict Wildfire Burn Severity

Author: Brieanne Forbes, Sean Reilly, Matthew Clark, Ryan Ferrell, Allison Kelly, Paris Krause, Corbin Matley, Michael O’Neil, Michelle Villasenor, Mathias Disney, Phil Wilkes, and Lisa Patrick Bentley
Subjects: ladder fuels, terrestrial laser scanner (TLS), handheld-mobile laser scanner (HMLS), unoccupied aerial system (UAS), airborne laser scanner (ALS), Structure from Motion (SfM), Forestry, SD1-669.5, Environmental sciences, GE1-350
Abstract: While fire is an important ecological process, wildfire size and severity have increased as a result of climate change, historical fire suppression, and lack of adequate fuels management. Ladder fuels, which bridge the gap between the surface and canopy leading to more severe canopy fires, can inform management to reduce wildfire risk. Here, we compared remote sensing and field-based approaches to estimate ladder fuel density. We also determined if densities from different approaches could predict wildfire burn severity (Landsat-based Relativized delta Normalized Burn Ratio; RdNBR). Ladder fuel densities at 1-m strata and 4-m bins (1–4 m and 1–8 m) were collected remotely using a terrestrial laser scanner (TLS), a handheld-mobile laser scanner (HMLS), an unoccupied aerial system (UAS) with a multispectral camera and Structure from Motion (SfM) processing (UAS-SfM), and an airborne laser scanner (ALS) in 35 plots in oak woodlands in Sonoma County, California, United States prior to natural wildfires. Ladder fuels were also measured in the same plots using a photo banner. Linear relationships among ladder fuel densities estimated at broad strata (1–4 m, 1–8 m) were evaluated using Pearson’s correlation (r). From 1 to 4 m, most densities were significantly correlated across approaches. From 1 to 8 m, TLS densities were significantly correlated with HMLS, UAS-SfM and ALS densities and UAS-SfM and HMLS densities were moderately correlated with ALS densities. Including field-measured plot-level canopy base height (CBH) improved most correlations at medium and high CBH, especially those including UAS-SfM data. The most significant generalized linear model to predict RdNBR included interactions between CBH and ladder fuel densities at specific 1-m stratum collected using TLS, ALS, and HMLS approaches (R2 = 0.67, 0.66, and 0.44, respectively). Results imply that remote sensing approaches for ladder fuel density can be used interchangeably in oak woodlands, except UAS-SfM combined with the photo banner. Additionally, TLS, HMLS and ALS approaches can be used with CBH from 1 to 8 m to predict RdNBR. Future work should investigate how ladder fuel densities using our techniques can be validated with destructive sampling and incorporated into predictive models of wildfire severity and fire behavior at varying spatial scales.
Published: 2022
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13. Depressive symptoms and myeloproliferative neoplasms: Understanding the confounding factor in a complex condition

Author: Leslie Padrnos, Robyn Scherber, Holly Geyer, Blake T. Langlais, Amylou C. Dueck, Heidi E. Kosiorek, Zhenya Senyak, Matthew Clark, Michael Boxer, Mary Cotter, Claire Harrison, Cynthia Stonnington, Yonas Geda, and Ruben Mesa
Subjects: depression, essential thrombocythemia, myelofibrosis, myeloproliferative neoplasm, PHQ‐2, polycythemia vera, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Philadelphia chromosome negative myeloproliferative neoplasms (MPNs), including essential thrombocythemia, polycythemia vera, and myelofibrosis, have severe function‐limiting symptom burden that is experienced by the majority of patients. Previous studies have suggested that depression may be present in over a quarter of MPN patients, but to date no studies have evaluated the relationship between depression and other variables such as symptoms. Methods A 70‐item internet based survey regarding fatigue and mood symptoms was developed by a multidisciplinary team of MPN investigators, patients and patient advocates including Patient Health Questionnaire and the Myeloproliferative Neoplasm Symptom Assessment Form was completed by over 1300 patients with MPN diagnosis. Results There were 309 respondents (23%) with PHQ‐2 scores ≥ 3. In this analysis, we found worse systemic symptom burden in individuals reporting depressive symptoms. Conclusion This analysis suggests the importance of depression in contributing to as well as confounding symptomatology in MPN patients, and suggests that this critical variable should also be addressed by clinicians and researchers alike when comprehensively assessing symptom burden etiologies.
Published: 2020
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14. Image-based Phenotyping Identifies Quantitative Trait Loci for Cluster Compactness in Grape

Author: Anna Underhill, Cory Hirsch, and Matthew Clark
Subjects: hybrid, imaging, qtl, vitis vinifera, Plant culture, SB1-1110
Abstract: Grape (Vitis vinifera) cluster compactness is an important trait due to its effect on disease susceptibility, but visual evaluation of compactness relies on human judgement and an ordinal scale that is not appropriate for all populations. We developed an image analysis pipeline and used it to quantify cluster compactness traits in a segregating hybrid wine grape (Vitis sp.) population for 2 years. Images were collected from grape clusters immediately after harvest, segmented by color, and analyzed using a custom script. Both automated and conventional phenotyping methods were used, and comparisons were made between each method. A partial least squares (PLS) model was constructed to evaluate the prediction of physical cluster compactness using image-derived measurements. Quantitative trait loci (QTL) on chromosomes 4, 9, 12, 16, and 17 were associated with both image-derived and conventionally phenotyped traits within years, which demonstrated the ability of image-derived traits to identify loci related to cluster morphology and cluster compactness. QTL for 20-berry weight were observed between years on chromosomes 11 and 17. Additionally, the automated method of cluster length measurement was highly accurate, with a deviation of less than 10 mm (r = 0.95) compared with measurements obtained with a hand caliper. A remaining challenge is the utilization of color-based image segmentation in a population that segregates for fruit color, which leads to difficulty in differentiating the stem from the fruit when the two are similarly colored in non-noir fruit. Overall, this research demonstrates the validity of image-based phenotyping for quantifying cluster compactness and for identifying QTL for the advancement of grape breeding efforts.
Published: 2020
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15. Haplotyping the Vitis collinear core genome with rhAmpSeq improves marker transferability in a diverse genus

Author: Cheng Zou, Avinash Karn, Bruce Reisch, Allen Nguyen, Yongming Sun, Yun Bao, Michael S. Campbell, Deanna Church, Stephen Williams, Xia Xu, Craig A. Ledbetter, Sagar Patel, Anne Fennell, Jeffrey C. Glaubitz, Matthew Clark, Doreen Ware, Jason P. Londo, Qi Sun, and Lance Cadle-Davidson
Subjects: Science
Abstract: Trait introgression requires universal markers, but cross-species transferability of current SNP markers can be as low as 2%. Here, the authors use an AmpSeq haplotype strategy targeting the collinear core genome for marker development and show transferability increases to 91.4% in the Vitis genus.
Published: 2020
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16. Which children and young people are at higher risk of severe disease and death after hospitalisation with SARS-CoV-2 infection in children and young people: A systematic review and individual patient meta-analysis

Author: Rachel Harwood, Helen Yan, Nishanthi Talawila Da Camara, Clare Smith, Joseph Ward, Catrin Tudur-Smith, Michael Linney, Matthew Clark, Elizabeth Whittaker, Defne Saatci, Peter J. Davis, Karen Luyt, Elizabeth S. Draper, Simon E Kenny, Lorna K. Fraser, and Russell M. Viner
Subjects: Child, Adolescent, COVID-19, SARS-CoV-2, Meta-analysis, Systematic review, Medicine (General), R5-920
Abstract: Summary: Background: We aimed to describe pre-existing factors associated with severe disease, primarily admission to critical care, and death secondary to SARS-CoV-2 infection in hospitalised children and young people (CYP), within a systematic review and individual patient meta-analysis. Methods: We searched Pubmed, European PMC, Medline and Embase for case series and cohort studies published between 1st January 2020 and 21st May 2021 which included all CYP admitted to hospital with ≥ 30 CYP with SARS-CoV-2 or ≥ 5 CYP with PIMS-TS or MIS-C. Eligible studies contained (1) details of age, sex, ethnicity or co-morbidities, and (2) an outcome which included admission to critical care, mechanical invasive ventilation, cardiovascular support, or death. Studies reporting outcomes in more restricted groupings of co-morbidities were eligible for narrative review. We used random effects meta-analyses for aggregate study-level data and multilevel mixed effect models for IPD data to examine risk factors (age, sex, comorbidities) associated with admission to critical care and death. Data shown are odds ratios and 95% confidence intervals (CI).PROSPERO: CRD42021235338 Findings: 83 studies were included, 57 (21,549 patients) in the meta-analysis (of which 22 provided IPD) and 26 in the narrative synthesis. Most studies had an element of bias in their design or reporting. Sex was not associated with critical care or death. Compared with CYP aged 1–4 years (reference group), infants (aged 14 years OR 2.15 (1.61–2.88)).The number of comorbid conditions was associated with increased odds of admission to critical care and death for COVID-19 in a step-wise fashion. Compared with CYP without comorbidity, odds ratios for critical care admission were: 1.49 (1.45–1.53) for 1 comorbidity; 2.58 (2.41–2.75) for 2 comorbidities; 2.97 (2.04–4.32) for ≥3 comorbidities. Corresponding odds ratios for death were: 2.15 (1.98–2.34) for 1 comorbidity; 4.63 (4.54–4.74) for 2 comorbidities and 4.98 (3.78–6.65) for ≥3 comorbidities. Odds of admission to critical care were increased for all co-morbidities apart from asthma (0.92 (0.91–0.94)) and malignancy (0.85 (0.17–4.21)) with an increased odds of death in all co-morbidities considered apart from asthma. Neurological and cardiac comorbidities were associated with the greatest increase in odds of severe disease or death. Obesity increased the odds of severe disease and death independently of other comorbidities. IPD analysis demonstrated that, compared to children without co-morbidity, the risk difference of admission to critical care was increased in those with 1 comorbidity by 3.61% (1.87–5.36); 2 comorbidities by 9.26% (4.87–13.65); ≥3 comorbidities 10.83% (4.39–17.28), and for death: 1 comorbidity 1.50% (0.00–3.10); 2 comorbidities 4.40% (-0.10–8.80) and ≥3 co-morbidities 4.70 (0.50–8.90). Interpretation: Hospitalised CYP at greatest vulnerability of severe disease or death with SARS-CoV-2 infection are infants, teenagers, those with cardiac or neurological conditions, or 2 or more comorbid conditions, and those who are obese. These groups should be considered higher priority for vaccination and for protective shielding when appropriate. Whilst odds ratios were high, the absolute increase in risk for most comorbidities was small compared to children without underlying conditions. Funding: RH is in receipt of a fellowship from Kidney Research UK (grant no. TF_010_20171124). JW is in receipt of a Medical Research Council Fellowship (Grant No. MR/R00160X/1). LF is in receipt of funding from Martin House Children's Hospice (there is no specific grant number for this). RV is in receipt of a grant from the National Institute of Health Research to support this work (grant no NIHR202322). Funders had no role in study design, data collection, analysis, decision to publish or preparation of the manuscript.
Published: 2022
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17. Coreceptor therapy has distinct short- and long-term tolerogenic effects intrinsic to autoreactive effector T cells

Author: Matthew Clark, Charles J. Kroger, Qi Ke, Rui Zhang, Karen Statum, J. Justin Milner, Aaron Martin, Bo Wang, and Roland Tisch
Subjects: Autoimmunity, Immunology, Medicine
Abstract: Immunotherapies are needed in the clinic that effectively suppress β cell autoimmunity and reestablish long-term self-tolerance in type 1 diabetes. We previously demonstrated that nondepleting anti-CD4 (αCD4) and αCD8α antibodies establish rapid and indefinite remission in recent-onset diabetic NOD mice. Diabetes reversal by coreceptor therapy (CoRT) is induced by suppression of pathogenic effector T cells (Teffs) and the selective egress of T cells from the pancreatic lymph nodes and islets that remain free of infiltration in the long term. Here, we defined CoRT-induced events regulating early Teff function and pancreatic residency, and long-term tolerance. TCR-driven gene expression controlling autoreactive Teff expansion and proinflammatory activity was suppressed by CoRT, and islet T cell egress was dependent on sphingosine-1 phosphate. In both murine and human T cells, CoRT upregulated the Foxo1 transcriptional axis, which in turn was required for suppression and efficient pancreatic egress of Teffs. Interestingly, long-term tolerance induced in late-preclinical NOD mice was marked by reseeding of the pancreas by a reduced CD8+ Teff pool exhibiting an exhausted phenotype. Notably, PD-1 blockade, which rescues exhausted Teffs, resulted in diabetes onset in protected animals. These findings demonstrate that CoRT has distinct intrinsic effects on Teffs that impact events early in induction and later in maintenance of self-tolerance.
Published: 2021
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18. Fine Mapping of Leaf Trichome Density Revealed a 747-kb Region on Chromosome 1 in Cold-Hardy Hybrid Wine Grape Populations

Author: Lu Yin, Avinash Karn, Lance Cadle-Davidson, Cheng Zou, Anna Underhill, Paul Atkins, Erin Treiber, Daniel Voytas, and Matthew Clark
Subjects: QTL mapping, fine mapping, trichome density, candidate gene, hybrid grape, phylloxera resistance, Plant culture, SB1-1110
Abstract: Segregation for leaf trichome density was observed in a cold-hardy hybrid grape population GE1025 (N = ∼125, MN1264 × MN1246) that was previously used to detect a quantitative trait locus (QTL) underlying foliar phylloxera resistance on chromosome 14. Our hypothesis was that high trichome density was associated with resistance to phylloxera. Existing literature found trichome density QTL on chromosomes 1 and 15 using a hybrid grape population of “Horizon” × Illinois 547-1 and suggested a few candidate genes. To validate the reported QTL and our hypothesis, interval mapping was conducted in GE1025 with previous genotyping-by-sequencing (GBS) single nucleotide polymorphism (SNP) genotype data and phenotypic scores collected using a 0–6 trichome density scale at several leaf positions. Evaluations were done on replicated forced dormant cuttings in 2 years and on field-grown leaves in 1 year. There was no strong relationship between trichome density and phylloxera resistance except for a Pearson’s correlation (r) of about -0.2 between a few trichome density traits and phylloxera severity traits at 2 and 3 weeks after infestation. Two genetic regions were repeatedly detected for multiple trichome density traits: from 10 to 20.7 Mbp (∼10 Mbp) on chromosome 1 for ribbon and simple density traits and from 2.4 to 8.9 Mbp on chromosome 10 for ribbon density traits, explaining 12.1–48.2 and 12.6–27.5% of phenotypic variation, respectively. To fine map, we genotyped a larger population, GE1783 (N = ∼1,023, MN1264 × MN1246), with conserved rhAmpSeq haplotype markers across multiple Vitis species and phenotyped 233 selected potential recombinants. Evaluations were conducted on field-grown leaves in a single year. The QTL for ribbon trichome density on adaxial vein and adaxial leaf and simple density on abaxial vein was fine mapped to 12.63–13.38 Mbp (747 kb) on chromosome 1. We found variations of MN1264 and MN1246 at candidate genes NAC transcription factor 29, EF-hand protein, and MYB140 in this region and three other surrounding candidate genes proposed previously. Even though no strong relationship between foliar phylloxera resistance and trichome density was found, this study validated and fine mapped a major QTL for trichome density using a cold-hardy hybrid grape population and shed light on a few candidate genes that have implications for different breeding programs.
Published: 2021
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19. The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes

Author: Matthew Clark, Charles J. Kroger, Qi Ke, and Roland M. Tisch
Subjects: autoimmunity, diabetes, immunoregulation, T cell receptor (TCR) signaling, T cell differentiation, Immunologic diseases. Allergy, RC581-607
Abstract: T cell receptor (TCR) signaling influences multiple aspects of CD4+ and CD8+ T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytokines also affect TCR signaling duration, as well as accessory pathways that further shape a T cell response. Type 1 diabetes (T1D) is a T cell-driven autoimmune disease targeting the insulin producing β cells in the pancreas. Evidence indicates that dysregulated TCR signaling events in T1D impact the efficacy of central and peripheral tolerance-inducing mechanisms. In this review, we will discuss how the strength and nature of TCR signaling events influence the development of self-reactive T cells and drive the progression of T1D through effects on T cell gene expression, lineage commitment, and maintenance of pathogenic anti-self T cell effector function.
Published: 2021
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20. Evolving Antibody Therapies for the Treatment of Type 1 Diabetes

Author: Qi Ke, Charles J. Kroger, Matthew Clark, and Roland M. Tisch
Subjects: diabetes, immunotherapy, monoclonal antibodies, immunoregulation, self-tolerance, Immunologic diseases. Allergy, RC581-607
Abstract: Type 1 diabetes (T1D) is widely considered to be a T cell driven autoimmune disease resulting in reduced insulin production due to dysfunction/destruction of pancreatic β cells. Currently, there continues to be a need for immunotherapies that selectively reestablish persistent β cell-specific self-tolerance for the prevention and remission of T1D in the clinic. The utilization of monoclonal antibodies (mAb) is one strategy to target specific immune cell populations inducing autoimmune-driven pathology. Several mAb have proven to be clinically safe and exhibit varying degrees of efficacy in modulating autoimmunity, including T1D. Traditionally, mAb therapies have been used to deplete a targeted cell population regardless of antigenic specificity. However, this treatment strategy can prove detrimental resulting in the loss of acquired protective immunity. Nondepleting mAb have also been applied to modulate the function of immune effector cells. Recent studies have begun to define novel mechanisms associated with mAb-based immunotherapy that alter the function of targeted effector cell pools. These results suggest short course mAb therapies may have persistent effects for regaining and maintaining self-tolerance. Furthermore, the flexibility to manipulate mAb properties permits the development of novel strategies to target multiple antigens and/or deliver therapeutic drugs by a single mAb molecule. Here, we discuss current and potential future therapeutic mAb treatment strategies for T1D, and T cell-mediated autoimmunity.
Published: 2021
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21. Sonoma County Complex Fires of 2017: Remote sensing data and modeling to support ecosystem and community resiliency

Author: Kass Green, Mark Tukman, Dylan Loudon, Allison Schichtel, Karen Gaffney, and Matthew Clark
Subjects: biodiversity, climate resiliency, data collaborations, fire, forest health, fuel loading, land conservation, land management, remote sensing, sonoma county, vegetation structure, vegetation type, Science
Abstract: In the western U.S., long-term fire suppression has led to a buildup of surface and ladder fuels, increasing the severity of fires. Coupled with increased home building in the wildland urban interface and global climate change, much of the western U.S. is facing unprecedented risk of catastrophic wildland fires. Given the almost 30 million acres of forestland in California, and the impacts to human community health and safety and natural systems that stem from uncontrolled fires, it is imperative that we understand the underlying processes and conditions in the landscape that determine fire impacts. In October of 2017, Sonoma County, California experienced three significant fires that resulted in loss of life and property, as well as impacts to natural systems. Sonoma County Ag + Open Space—with support from a team of technical consultants and in partnership with NASA and other experts—researched the impacts of the fires to woody vegetation within areas that burned during wind-driven and non-wind driven events. Using high-resolution aerial imagery, we mapped canopy condition of woody vegetation and used machine learning techniques to determine the importance of landscape measures of vegetation structure, land cover type, topography, climate and weather, and nearness to streams as predictors of woody canopy condition for areas that burned during the October 2017 fires. Across the landscapes, riparian and mesic vegetation types exhibited the least canopy damage, followed by upland hardwood forest types. Shrub and upland conifer types exhibited the most canopy damage. Measures of vegetation structure derived from lidar data are the most important predictors of post-fire woody canopy condition, in addition to slope-aspect, proximate vegetation community types, and distance to streams. In general, the higher the density of shrubs and fire-adapted vegetation types, the higher the density of ladder fuels, and the greater the distance from streams, the higher the canopy damage. This study emphasizes the value of high resolution airborne lidar for mapping vegetation type and structure and building locations at a scale large enough to inform local management decisions. The study also documents pre- and post-fire baseline conditions to support the long-term evaluation of vegetation impacts and provides remote sensing and analysis tools to better plan for, manage, and mitigate future extreme wildfire through the lens of climate and extreme event resiliency, community safety and ecosystem health.
Published: 2020
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22. Collecting and utilising crowdsourced data for numerical weather prediction: Propositions from the meeting held in Copenhagen, 4–5 December 2018

Author: Kasper S. Hintz, Katharine O'Boyle, Sarah L. Dance, Saja Al‐Ali, Ivar Ansper, Dick Blaauboer, Matthew Clark, Alexander Cress, Mohamed Dahoui, Rónán Darcy, Juhana Hyrkkanen, Lars Isaksen, Eigil Kaas, Ulrik S. Korsholm, Marion Lavanant, Gwenaelle Le Bloa, Emilie Mallet, Callie McNicholas, Jeanette Onvlee‐Hooimeijer, Bent Sass, Valeria Siirand, Henrik Vedel, Joanne A. Waller, and Xiaohua Yang
Subjects: citizen science, crowdsourcing, data collection, opportunistic data, quality control, third‐party data, Meteorology. Climatology, QC851-999
Abstract: Abstract In December 2018, the Danish Meteorological Institute organised an international meeting on the subject of crowdsourced data in numerical weather prediction (NWP) and weather forecasting. The meeting, spanning 2 days, gathered experts on crowdsourced data from both meteorological institutes and universities from Europe and the United States. Scientific presentations highlighted a vast array of possibilities and progress being made globally. Subjects include data from vehicles, smartphones, and private weather stations. Two groups were created to discuss open questions regarding the collection and use of crowdsourced data from different observing platforms. Common challenges were identified and potential solutions were discussed. While most of the work presented was preliminary, the results shared suggested that crowdsourced observations have the potential to enhance NWP. A common platform for sharing expertise, data, and results would help crowdsourced data realise this potential.
Published: 2019
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23. A closer look at ARSA activity in a patient with metachromatic leukodystrophy

Author: Kathleen Doherty, S. Barron Frazier, Matthew Clark, Anna Childers, Sumit Pruthi, David A. Wenger, and Jessica Duis
Subjects: Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease mainly caused by a deficiency of arylsulfatase A activity. The typical clinical course of patients with the late infantile form includes a regression in motor skills with progression to dysphagia, seizures, hypotonia and death. We present a case of a 4-year-old female with rapidly progressive developmental regression with loss of motor milestones, spasticity and dysphagia. MRI showed volume loss and markedly abnormal deep white matter. Enzymatic testing in one laboratory showed arylsulfatase A activity in their normal range. However, extraction of urine showed a large increase in sulfatide excretion in a second laboratory. Measurement of arylsulfatase A in that laboratory showed a partial decrease in arylsulfatase A activity measured under typical conditions (about 37% of the normal mean). When the concentration of substrate in the assay was lowered to one quarter of that normally used, this individual had activity
Published: 2019
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24. A Naturalistic Observation of Spontaneous Touches to the Body and Environment in the First 2 Months of Life

Author: Abigail DiMercurio, John P. Connell, Matthew Clark, and Daniela Corbetta
Subjects: touch, self-touch, infancy, embodiment, sensorimotor experience, emerging self, Psychology, BF1-990
Abstract: Self-generated touches to the body or supporting surface are considered important contributors to the emergence of an early sense of the body and self in infancy. Both are critical for the formation of later goal-directed actions. Very few studies have examined in detail the development of these early spontaneous touches during the first months of life. In this study, we followed weekly four infants in two naturalistic 5-min sessions (baseline and toys-in-view) as they laid alert in supine from the age of 3 weeks until they acquired head control. We found that throughout the 2 months of observation, infants engaged in a high rate of touch and spent about 50% of the time moving their hands from one touch location to the next. On most sessions, they produced up to 200 body/surface contacts and touched as many as 18 different areas (mainly upper body and floor) both hands combined. When we did not consider the specific areas touched, the rates of touches were higher to the body than to the floor, but the duration of contacts and the most touched areas were higher for the supporting surface than for the body. Until the age of 9 weeks, we found no consistent differences in the rate of touch between head and trunk. Infants also did not display significant differences in their rate of touch between right and left hand or between conditions. However, we discovered that in the earlier weeks, infants engaged more often in what we called “complex touches.” Complex touches were touches performed across several body/floor areas in one continuous bout while the hand maintained contact with the body or floor. Single touches, in contrast, corresponded to one touch to one single body or floor area at a time. We suggest that infants are active explorers of their own body and peripersonal space from day 1 and that these early self-generated and deeply embodied sensorimotor experiences form the critical foundation from which future behaviors develop.
Published: 2018
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25. Incorporating canopy structure from simulated GEDI lidar into bird species distribution models

Author: Patrick Burns, Matthew Clark, Leonardo Salas, Steven Hancock, David Leland, Patrick Jantz, Ralph Dubayah, and Scott J Goetz
Subjects: bird species distribution models, GEDI, lidar, canopy structure, machine learning, Environmental technology. Sanitary engineering, TD1-1066, Environmental sciences, GE1-350, Science, Physics, QC1-999
Abstract: The Global Ecosystem Dynamics Investigation (GEDI) lidar began data acquisition from the International Space Station in March 2019 and is expected to make over 10 billion measurements of canopy structure and topography over two years. Previously, airborne lidar data with limited spatial coverage have been used to examine relationships between forest canopy structure and faunal diversity, most commonly bird species. GEDI’s latitudinal coverage will permit these types of analyses at larger spatial extents, over the majority of the Earth’s forests, and most importantly in areas where canopy structure is complex and/or poorly understood. In this regional study, we examined the impact that GEDI-derived Canopy Structure variables have on the performance of bird species distribution models (SDMs) in Sonoma County, California. We simulated GEDI waveforms for a two-year period and then interpolated derived Canopy Structure variables to three grid sizes of analysis. In addition to these variables, we also included Phenology, Climate, and other Auxiliary variables to predict the probability of occurrence of 25 common bird species. We used a weighted average ensemble of seven individual machine learning models to make predictions for each species and calculated variable importance. We found that Canopy Structure variables were, on average at our finest resolution of 250 m, the second most important group (32.5%) of predictor variables after Climate variables (35.3%). Canopy Structure variables were most important for predicting probability of occurrence of birds associated with Conifer forest habitat. Regarding spatial analysis scale, we found that finer-scale models more frequently performed better than coarser-scale models, and the importance of Canopy Structure variables was greater at finer spatial resolutions. Overall, GEDI Canopy Structure variables improved SDM performance for at least one spatial resolution for 19 of 25 species and thus show promise for improving models of bird species occurrence and mapping potential habitat.
Published: 2020
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26. Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes

Author: Charles J. Kroger, Matthew Clark, Qi Ke, and Roland M. Tisch
Subjects: autoimmunity, diabetes, immunoregulation, immunotherapy, Immunologic diseases. Allergy, RC581-607
Abstract: Type 1 diabetes (T1D) is an autoimmune disease that is generally considered to be T cell-driven. Accordingly, most strategies of immunotherapy for T1D prevention and treatment in the clinic have targeted the T cell compartment. To date, however, immunotherapy has had only limited clinical success. Although certain immunotherapies have promoted a protective effect, efficacy is often short-term and acquired immunity may be impacted. This has led to the consideration of combining different approaches with the goal of achieving a synergistic therapeutic response. In this review, we will discuss the status of various T1D therapeutic strategies tested in the clinic, as well as possible combinatorial approaches to restore β cell tolerance.
Published: 2018
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27. Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response

Author: Matthew Clark, Charles J. Kroger, and Roland M. Tisch
Subjects: autoimmunity, type 1 diabetes, immunoregulation, inflammation, T cells, Immunologic diseases. Allergy, RC581-607
Abstract: Inflammation is typically induced in response to a microbial infection. The release of proinflammatory cytokines enhances the stimulatory capacity of antigen-presenting cells, as well as recruits adaptive and innate immune effectors to the site of infection. Once the microbe is cleared, inflammation is resolved by various mechanisms to avoid unnecessary tissue damage. Autoimmunity arises when aberrant immune responses target self-tissues causing inflammation. In type 1 diabetes (T1D), T cells attack the insulin producing β cells in the pancreatic islets. Genetic and environmental factors increase T1D risk by in part altering central and peripheral tolerance inducing events. This results in the development and expansion of β cell-specific effector T cells (Teff) which mediate islet inflammation. Unlike protective immunity where inflammation is terminated, autoimmunity is sustained by chronic inflammation. In this review, we will highlight the key events which initiate and sustain T cell-driven pancreatic islet inflammation in nonobese diabetic mice and in human T1D. Specifically, we will discuss: (i) dysregulation of thymic selection events, (ii) the role of intrinsic and extrinsic factors that enhance the expansion and pathogenicity of Teff, (iii) defects which impair homeostasis and suppressor activity of FoxP3-expressing regulatory T cells, and (iv) properties of β cells which contribute to islet inflammation.
Published: 2017
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28. Effects of Harvest Time on the Aroma of White Wines Made from Cold-Hardy Brianna and Frontenac Gris Grapes Using Headspace Solid-Phase Microextraction and Gas Chromatography-Mass Spectrometry-Olfactometry

Author: Somchai Rice, Madina Tursumbayeva, Matthew Clark, David Greenlee, Murlidhar Dharmadhikari, Anne Fennell, and Jacek A. Koziel
Subjects: Frontenac gris, Brianna, wine aroma, SPME-GC-MS, olfactometry, cold-hardy grapes, Chemical technology, TP1-1185
Abstract: The Midwest wine industry has shown a marked increase in growers, hectares planted, wineries, and wine production. This growth coincides with the release of cold-hardy cultivars such as Brianna and Frontenac gris, in 2001 and 2003, respectively. These white grape varieties account for one-third of the total area grown in the state of Iowa. It is generally accepted that the wine aroma profile plays a crucial role in developing a local, sustainable brand. However, the identity of Brianna/Frontenac Gris-based wine aromas and their link to the grape berry chemistry at harvest is unknown. This study aims to preliminarily characterize key odor-active compounds that can influence the aroma profile in wines made from Brianna and Frontenac gris grapes harvested at different stages of ripening. Brianna and Frontenac gris grapes were harvested approximately 7 days apart, starting at 15.4 °Brix (3.09 pH) and 19.5 °Brix (3.00 pH), respectively. Small batch fermentations were made for each time point with all juices adjusted to the same °Brix prior to fermentation. Odor-active compounds were extracted from wine headspace using solid-phase microextraction (SPME) and analyzed by gas chromatography-mass spectrometry (GC-MS) and simultaneous olfactometry (O). Over 30 odor-active compounds were detected. Aromas in Brianna wines developed from “cotton candy” and “floral”, to “banana” and “butterscotch”, then finally to “honey”, “caramel” and an unknown neutral aroma. Frontenac gris wines changed from an unknown neutral aroma to “fruity” and “rose”. Results from the lay audiences’ flavor and aroma descriptors also indicate a shift with harvest date and associated °Brix. To date, this is the first report of wine aromas from Brianna and Frontenac gris by GC-MS-O. Findings from this research support the hypothesis that aroma profiles of Brianna and Frontenac gris wines can be influenced by harvesting the grapes at different stages of ripening.
Published: 2019
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29. Lessons from Fraxinus, a crowd-sourced citizen science game in genomics

Author: Ghanasyam Rallapalli, Fraxinus Players, Diane GO Saunders, Kentaro Yoshida, Anne Edwards, Carlos A Lugo, Steve Collin, Bernardo Clavijo, Manuel Corpas, David Swarbreck, Matthew Clark, J Allan Downie, Sophien Kamoun, Team Cooper, and Dan MacLean
Subjects: Hymenoscyphus fraxinea, ash, crowdsourcing, citizen science, Medicine, Science, Biology (General), QH301-705.5
Abstract: In 2013, in response to an epidemic of ash dieback disease in England the previous year, we launched a Facebook-based game called Fraxinus to enable non-scientists to contribute to genomics studies of the pathogen that causes the disease and the ash trees that are devastated by it. Over a period of 51 weeks players were able to match computational alignments of genetic sequences in 78% of cases, and to improve them in 15% of cases. We also found that most players were only transiently interested in the game, and that the majority of the work done was performed by a small group of dedicated players. Based on our experiences we have built a linear model for the length of time that contributors are likely to donate to a crowd-sourced citizen science project. This model could serve a guide for the design and implementation of future crowd-sourced citizen science initiatives.
Published: 2015
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30. Breastfeeding and infant temperament at age three months.

Author: Blandine de Lauzon-Guillain, Katrien Wijndaele, Matthew Clark, Carlo L Acerini, Ieuan A Hughes, David B Dunger, Jonathan C Wells, and Ken K Ong
Subjects: Medicine, Science
Abstract: BACKGROUND & METHODS:To examine the relationship between breastfeeding and maternally-rated infant temperament at age 3 months, 316 infants in the prospective Cambridge Baby Growth Study, UK had infant temperament assessed at age 3 months by mothers using the Revised Infant Behavior Questionnaire, which produces scores for three main dimensions of temperament derived from 14 subscales. Infant temperament scores were related to mode of infant milk feeding at age 3 months (breast only; formula milk only; or mixed) with adjustment for infant's age at assessment and an index of deprivation. RESULTS:Infant temperament dimension scores differed across the three infant feeding groups, but appeared to be comparable between exclusive breast-fed and mixed-fed infants. Compared to formula milk-fed infants, exclusive breast-fed and mixed-fed infants were rated as having lower impulsivity and positive responses to stimulation (adjusted mean [95% CI] "Surgency/Extraversion" in formula-fed vs. mixed-fed vs. breast-fed groups: 4.3 [4.2-4.5] vs. 4.0 [3.8-4.1] vs. 4.0 [3.9-4.1]; p-heterogeneity = 0.0006), lower ability to regulate their own emotions ("Orienting/Regulation": 5.1 [5.0-5.2], vs. 4.9 [4.8-5.1] vs. 4.9 [4.8-5.0]; p = 0.01), and higher emotional instability ("Negative affectivity": 2.8 [2.6-2.9] vs. 3.0 [2.8-3.1] vs. 3.0 [2.9-3.1]; p = 0.03). CONCLUSIONS:Breast and mixed-fed infants were rated by their mothers as having more challenging temperaments in all three dimensions; particular subscales included greater distress, less smiling, laughing, and vocalisation, and lower soothability. Increased awareness of the behavioural dynamics of breastfeeding, a better expectation of normal infant temperament and support to cope with difficult infant temperament could potentially help to promote successful breastfeeding.
Published: 2012
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31. Reductions in inpatient mortality following interventions to improve emergency hospital care in Freetown, Sierra Leone.

Author: Matthew Clark, Emily Spry, Kisito Daoh, David Baion, and Jolene Skordis-Worrall
Subjects: Medicine, Science
Abstract: BACKGROUND: The demand for high quality hospital care for children in low resource countries is not being met. This paper describes a number of strategies to improve emergency care at a children's hospital and evaluates the impact of these on inpatient mortality. In addition, the cost-effectiveness of improving emergency care is estimated. METHODS AND FINDINGS: A team of local and international staff developed a plan to improve emergency care for children arriving at The Ola During Children's Hospital, Freetown, Sierra Leone. Following focus group discussions, five priority areas were identified to improve emergency care; staff training, hospital layout, staff allocation, medical equipment, and medical record keeping. A team of international volunteers worked with local staff for six months to design and implement improvements in these five priority areas. The improvements were evaluated collectively rather than individually. Before the intervention, the inpatient mortality rate was 12.4%. After the intervention this improved to 5.9%. The relative risk of dying was 47% (95% CI 0.369-0.607) lower after the intervention. The estimated number of lives saved in the first two months after the intervention was 103. The total cost of the intervention was USD 29 714, the estimated cost per death averted was USD 148. There are two main limitation of the study. Firstly, the brevity of the study and secondly, the assumed homogeneity of the clinical cases that presented to the hospital before and after the intervention. CONCLUSIONS: This study demonstarted a signficant reductuion in inpatient mortality rate after an intervention to improve emergency hospital care If the findings of this paper could be reproduced in a larger more rigorous study, improving the quality of care in hospitals would be a very cost effective strategy to save children's lives in low resource settings.
Published: 2012
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32. From Paragraphs to Plots: Architecture of the Novel

Author: Matthew Clark
Published: 2024

33. Transfer Learning for Mortality Prediction in Non-Small Cell Lung Cancer with Low-Resolution Histopathology Slide Snapshots.

Author: Matthew Clark, Christopher Meyer, Jaime Ramos-Cejudo, Danne C. Elbers, Karen E. Pierce-Murray, Rafael Fricks, Gil Alterovitz, Luigi Rao, Mary T. Brophy, Nhan V. Do, Robert L. Grossman, and Nathanael R. Fillmore
Published: 2023
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34. How to Reread a Novel

Author: Matthew Clark
Published: 2023

35. Formal Compositional Reasoning of Autonomous Aerial Systems with Complex Algorithms.

Author: Milton Stafford, Siddhartha Bhattacharyya, Matthew Clark, and Natasha A. Neogi
Published: 2020
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36. Analyzing Privacy Practices of Existing mHealth Apps.

Author: Aarathi Prasad, Matthew Clark, Ha Linh Nguyen, Rubén Ruiz, and Emily Xiao
Published: 2020
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37. Twine: A Unified Cluster Management System for Shared Infrastructure.

Author: Chunqiang Tang, Kenny Yu, Kaushik Veeraraghavan, Jonathan Kaldor, Scott Michelson, Thawan Kooburat, Aravind Anbudurai, Matthew Clark, Kabir Gogia, Long Cheng, Ben Christensen, Alex Gartrell, Maxim Khutornenko, Sachin Kulkarni, Marcin Pawlowski 0003, Tuomas Pelkonen, Andre Rodrigues, Rounak Tibrewal, Vaishnavi Venkatesan, and Peter Zhang
Published: 2020

38. Moving Recursion Out of the RDBMS for Transactional Graph Workloads.

Author: Christine F. Reilly and Matthew Clark
Published: 2020
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39. Integration of Quantifier Eliminator with Model Checker and Compositional Reasoner.

Author: Hao Ren 0004, Matthew Clark, and Ratnesh Kumar 0001
Published: 2018
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40. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY)

Author: Obbina Abani, Ali Abbas, Fatima Abbas, Joshua Abbas, Kasim Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Alison Abbott, Nabeel Abdallah, Ammar Abdelaziz, Ashraf Abdelaziz, Mohamed Abdelfattah, Bushra Abdelqader, Audrey Abdul, Basir Abdul, Siddiqui Abdul, Althaf Abdul Rasheed, Ajibode Abdulakeem, Rezan Abdul-Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Abeer Ul Amna, Lynn Abel, Katrina Abernethy, Movin Abeywickrema, Chandra Abhinaya, Affyarsyah Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Christopher Aboah, Heba Aboelela, Hani Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, Mona Abouzaid, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Rebecca Abrams, Hyacinth-John Abu, Ahmed Abu-Arafeh, Syed M Abubacker, Akata Abung, Yousuf Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Faustina Acheampong, Prince Acheampong, Sarah Acheampong, Janet Acheson, Shiella Achieng, Andres Acosta, Rebecca Acquah, Catherine Acton, Jacqueline Adabie-Ankrah, Paul Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Marta Adamczyk, Carol Adams, Charlotte Adams, Daniel Adams, Kate Adams, Laura Adams, Nikkita Adams, Richard Adams, Tim Adams, Laura Adamu-Ikeme, Krishma Adatia, Kirsty Adcock, Lawrence Addai-Boampong, Afua Addo, Oluwatobi Adeagbo, Ade Adebiyi, Ogunlana Adedeji, Yewande Adegeye, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Femi W Adeoye, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Adedamola Adeyanju, Joyce Adeyemi, Tenifayo Adeyemo, Binay Adhikari, Shanti A Adhikari, Rina Adhikary, Adhikarla Aditya, Patience Adjepong, Gabrielle Adkins, Adnan Adnan, Marguerite Adriaanse, John Aeron-Thomas, Debbie Affleck, Carmel Afnan, Muhammad Afridi, Patricia Afrim, Felicia Akua Afriyie, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, Laura Aguilar Jimenez, Jacqueline Afrakomah Agyekum, Kwame Agyen, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Mohammad Ahmad, Syed Ahmad, Afshan Ahmed, Ashar Ahmed, Asim Ahmed, Basheer A R Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Hanad Ahmed, Irshad Ahmed, Khaled Ahmed, Khalil Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rawya Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sana G Ahmed, Syed Ahmed, Syed H Ahmed, Roa Ahmed Ali, Bilal Ahmed Mohamud, Sana Ahmed, Sana Ahmer, Augustine Ahonia, Christine Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Bolutito Akinbiyi, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Mohammad Akram, Olugbenro Aktinade, Uzayr Akudi, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al-Abadi, Adegoke Alabi, Narendra Aladangady, Mohamed Alafifi, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki Alatzoglou, Paul Albert, Albertus Albertus, Lorraine Albon, Angela Alcala, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ram Maya Ale, Ana Alegria, Alison Alexander, Courtney Alexander, John Alexander, Peter D G Alexander, Julyan Al-fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, Rafil Alhameed, Mohammed Al-Hayali, Shams Al-Hity, Ali Ali, Amanda Ali, Asad Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohamed Ali, Mohammad Ali, Muhammad S Ali, Nayab Ali, Oudai Ali, Ramla Ali, Sakina Ali, Syed Ali, Emilio Aliberti, Jade Alin, Abid Alina, Analyn Alipustain, Bachti Alisjahbana, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Abdullah Alkhudhayri, Moutaz Alkhusheh, Fiona Allan, Nataliya Allan, Alison Allanson, Robert Allcock, Eireann Allen, Jade Allen, Kerry Allen, Louise Allen, Poppy Allen, 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Czekaj, Patrycja Czylok, Shane D'Souza, Joana da Rocha, Mohammed Dafalla, Andrew Dagens, Helen Daggett, Jacqui Daglish, Sandeep Dahiya, Anne Dale, Katie Dale, Michaela Dale, Sam Dale, Susan Dale, Jolyon Dales, Umberto D'Alessandro, Helen Dalgleish, Helen Dallow, Carlo D'aloia, Dermot Dalton, Morag Dalton, Zoe Daly, Mansi Damani, Eleanor Damm, Akila Danga, Joanne Dangerfield, Amelia Daniel, Priya Daniel, Allison Daniels, Adela Dann, Kwaku Gyasi Danso, Sandra Danso-Bamfo, Quang Tung Dao, Suzanne Darby, Alex Darbyshire, Janet Darbyshire, Paul Dargan, Paul Dark, Kate Darlington, Sarah Darnell, Thomas Darton, Guledew Darylile, Avisnata Das, Manjusha Das, Sukamal Das, Martin Daschel, Joanne Dasgin, Dibyendu Datta, Anna Daunt, Vaishali Dave, Emily Davenport, Mark Davey, Miriam Davey, Molly Davey, Mini David, Alexander Davidson, Laura Davidson, Neil Davidson, Richard Davidson, Albert Davies, Alison Davies, Amanda Davies, Amy Davies, Angela Davies, Bethan Davies, Caroline Davies, Carolyn 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Souza, Anthony De Soyza, Natasha de Vere, Johannes de Vos, Bethan Deacon, Sharon Dealing, Anna Dean, Julie Dean, Katrina Dean, Stephen Dean, Tessa Dean, Jill Deane, James Dear, Effie Dearden, Catherine Deas, Samuel Debbie, Gabor Debreceni, Vashist Deelchand, Matthew Deeley, Joanne Deery, Emmanuel Defever, Manuela Del Forno, Arnold Dela Rosa, Gonzalo De-La-Cedra, Amanda Dell, Carrie Demetriou, David DeMets, Jane Democratis, Jacqueline Denham, Emmanuelle Denis, Laura Denley, Craig Denmade, Alexandra Dent, Kathy Dent, Martin Dent, Elise Denton, Tom Denwood, Nishigandh Deole, Darshita Depala, Maria Depante, Susan Dermody, Amisha Desai, Asmita Desai, Purav Desai, Sanjeev Deshpande, Vai Deshpande, Sirjana Devkota, Usha Devkota, Debbie Devonport, Matthew Devonport, Prakash Dey, Vishal Dey, Rogin Deylami, Kevin Dhaliwal, Sundip Dhani, Amandeep Dhanoa, Mili Dhar, Ankush Dhariwal, Dawpadee Dharmasena, Devesh Dhasmana, Ekanjali Dhillon, Reiss Dhillon, Syra Dhillon, Meghnath Dhimal, Dipali Dhiru, Trupti Dhorajiwala, Priya Dias, Stephanie Diaz, Kayleigh Diaz-Pratt, Mohammed Dibas, Debbie Dickerson, Pamela Dicks, Matt Dickson, Stuart Dickson, J Digby, Ronneil Digpal, Sean Dillane, Sarah Diment, Paul Dimitri, Georgios Dimitriadis, Sajeel Din, Thai H Dinh, Thi T T Dinh, Alex Dipper, Sabiq Dipro, Laura Dirmantaite, Lorelle Dismore, Lisa Ditchfield, Sarah Diver, Lavanya Diwakar, Preeti Diwan, Caroline Dixon, Giles Dixon, Kate Dixon, Brice Djeugam, Sipho Dlamini, Petr Dlouhy, Andrea D'Mello, Paul Dmitri, Thi Tien Do, Laurence Dobbie, Marinela Dobranszky Oroian, Charlotte Dobson, Lee Dobson, Marie Docherty, David Dockrell, Jacqueline Dodd, James Dodd, Jackie Dodds, Rebecca Dodds, Steve Dodds, Richi Dogra, Conor Doherty, Erin Doherty, Warren Doherty, Yumiko Doi, Iain Doig, Eleanor Doke, Daniel Dolan, Mark Dolman, Rozzie Dolman, Lisa Donald, Katie Donald, Callum Donaldson, Christopher Donaldson, Denise Donaldson, Gillian Donaldson, Kate Donaldson, Phu Khiem Dong, Martha Donkor, Sinead Donlon, Joanne Donnachie, Eilish Donnelly, Ronan Donnelly, Phil Donnison, Aravindhan Donohoe, Gemma Donohoe, Bryan Donohue, Emma Dooks, Reece J Doonan, Rogier Van Doorn, Grainne Doran, Rachael Dore, Kane Dorey, Sharon Dorgan, Kataryna Dos Santos, Moonira Dosani, Davinder Dosanjh, Paula Dospinescu, Isabelle Doss, Theonymfi Doudouliaki, Andrew Dougherty, Jill Doughty, Katie Douglas, Jonathan Douse, Allyn Dow, Lucy Dowden, Michelle Dower, Sud Dowling, Nicola Downer, Charlotte Downes, Rob Downes, Thomas Downes, Damian Downey, Robert Downey, Caroline Downing, Louise Downs, Simon Dowson, Cornel Dragan, Cristina Dragos, Maire Drain, Chelsea Drake, Victoria Drew, Olivia Drewett, Anthony Drexel, Celine Driscoll, Helena Drogan, Odysseas Drosos, Graham Drummond, Katie Drury, Kay Druryk, Ronald Druyeh, Jack Dryburgh-Jones, Simon Drysdale, An Du Thinh, Hazel Dube, Judith Dube, Stephen Duberley, Paige K Duckenfield, Hayley Duckles-Leech, Nicola Duff, Emma Duffield, Heather Duffy, Helen Duffy, Katharine Duffy, Lionel Dufour, Annette Duggan, Parveen Dugh, Rauand Duhoky, Janice Duignan, Jennifer Dulay, Simon Dummer, Alexis Duncan, Andrew Duncan, Christopher Duncan, Fullerton Duncan, Gregory Duncan, Holly Duncan, Robert Duncan, Stephanie Dundas, Do Van Dung, Aileen Dunleavy, Julia Dunleavy, Alessia Dunn, Charlotte Dunn, Damian Dunn, Laura Dunn, Paul Dunn, Charlene Dunne, Karen Dunne, Fiona Dunning, Aidan Dunphy, Tran Thi Hai Duong, Venkat Duraiswamy, Beatriz Duran, Ingrid DuRand, Leanne Durdle, Natalie Duric, Alison Durie, Emily Durie, Samuel Durogbola, Chris Durojaiye, Laura Durrans, Katie Durrant, Hannah Durrington, Iheukwumere Duru, Haris Duvnjak, Akshay Dwarakanath, Laasya Dwarakanath, Dennis Dwomoh Nkrumah, Ellen Dwyer, Zara Dyar, Claudia Dyball, Kristyn Dyer, Harvey Dymond, Tom Dymond, Chris Eades, Lauren Eadie, Rebekah Eadie, Laura Eagles, Beena Eapen, Naomi Earl, Joanne Early, Melissa Earwaker, Nicholas Easom, Clare East, Amy Easthope, Fraser Easton, Jack Easton, Patrick Easton, Ruth Eatough, Oluwadamilola Ebigbola, Martin Ebon, Alison Eccles, Sinan Eccles, Chloe Eddings, Michael Eddleston, Maureen Edgar, Katharine Edgerley, Nicholas Edmond, Mary Edmondson, Tracy Edmunds, Abby Edwards, Alexandra Edwards, Catherine Edwards, Joy Edwards, Kennedy Edwards, Mandy Edwards, Martin Edwards, Sophie Edwards, Jenny Eedle, Aline Eggink, Dawn Egginton, Sam Eggleston, Loveth Ehiorobo, Sarah Eisen, Ugochukwu Ekeowa, Mohamed Ekoi, Ayomide Ekunola, Soha El Behery, Nagla Elashhar, Lisa Elawamy, Mohamed Elbeshy, Kate El-Bouzidi, Jennifer Elder, Mohammed El-Din, Emma Eldridge, Diana Eleanor, Uchenna Elenwa, Ibrahim Eletu, Eman Elfar, Mayy Magdy Elgamal, Amr Elgohary, Mohamed A A Elhadi, Stellios Elia, Jennifer Elias, Tania Elias, Nadia Elkaram, Andrew V Elkins, Julie Ellam, Nikki Ellard, Laura N Ellerton, Lucy Elliot, Amy Elliott, Fiona Elliott, Kerry Elliott, Scott Elliott, Sian Elliott, Annie Ellis, Christine Ellis, Kaytie Ellis, Leila Ellis, Rupert Ellis, Tak-Yan Ellis, Yvette Ellis, Alison C Ellwood, Rahma Elmahdi, Einas Elmahi, Hannah-May Elmasry, Mohammed El-Naggar, Najla Elndari, Omer Elneima, Mohamed Elokl, Ahmed Elradi, Mohamed Elsaadany, Mohammed A S A Elsayed, Sally El-Sayeh, Hana El-Sbahi, Mohammad Elsebaei, Tarek Elsefi, Karim El-Shakankery, Alguili Elsheikh, Hosni El-Taweel, Sarah Elyoussfi, Jonathan Emberey, Jonathan R Emberson, John Emberton, Anna Emery, Julian Emmanuel, Ingrid Emmerson, Michael Emms, Florence Emond, Marieke Emonts, Nicu Enachi, Dickson Enenche, Angila Engden, Katy English, Emma Entwistle, Hene Enyi, Marios Erotocritou, Peter Eskander, Hanif Esmail, Fatheha Essa, Brynach Evans, Chris Evans, Debra Evans, E Evans, Emrys Evans, Gail Evans, Gareth Evans, Isabel Evans, Jack Evans, Jacqueline Evans, Jennifer Evans, John Evans, Jolanta Evans, Lisa Evans, Lynn Evans, Mim Evans, Morgan Evans, Ranoromanana Evans, Sharon Evans, Sian Evans, Teriann Evans, Tomos Evans, Caroline Everden, Serenydd Everden, Lynette Every, Hayley Evison, Lynsey Evison, Chiamaka Ezenduka, Jacqueline Faccenda, Leila Fahel, Youstina Fahmay, Ian Fairbairn, Sara Fairbairn, Terry Fairbairn, Andy Fairclough, Louise Fairlie, Mark Fairweather, Anne Fajardo, Naomi Falcone, Euan Falconer, John Fallon, Andrea Fallow, David Faluyi, Victoria Fancois, Ayaan Farah, Muna Farah, Qayyum Farah, Nowin Z Fard, Leila Fares, Amr Farg, Adam Farmer, Katie Farmer, Toni Farmery, Samantha Farnworth, Faiyaz Farook, Hadia Farooq, Sidrah Farooq, Fiona Farquhar, Holly Farr, Aaron Farrell, Barbara Farrell, Fayed Farrukh, James Farthing, Syeda Farzana, Rahmatu Fasina, Azam Fatemi, Mina Fatemi, Suman Fathima, Nibah Fatimah, Maria Faulkner, Saul N Faust, Clair Favager, Joe Fawke, Sinmidele Fawohunre, Abul Fazal, Aisthath Fazleen, Simon Fearby, Connie Fearnley, Alex Feben, Federico Fedel, Daria Fedorova, Christopher Fegan, Mae Felongo, Lynsey Felton, Tim Felton, Kate Fenlon, Andrea Fenn, Ruth Fennelly, Isabelle Fenner, Ciara Fenton, Melisa Fenton, Gloria Ferenando, Cameron Ferguson, Jenny Ferguson, Kathryn Ferguson, Katie Ferguson, Susan Ferguson, Susie Ferguson, Victoria Ferguson, Denzil Fernandes, Candida Fernandez, Eduardo Fernandez, Maria Fernandez, Sonia Fernandez Lopez, Jaime Fernandez Roman, Callum J Fernando, Jessica Fernando, Ahmed Feroz, Pietro Ferranti, Thais Ferrari, Eleanor Ferrelly, Alexandra Ferrera, Emma Ferriman, Sheldon Ferron, Nicholas Fethers, Ben Field, Janet Field, Rebecca Field, Karen Fielder, Lindsey Fieldhouse, Andra Fielding, Julie Fielding, Sarah Fielding, Asma Fikree, Santos Filipa, Sarah A Filson, Shona Finan, Sarah Finbow, Deborah J Finch, Joanne Finch, Laurie Finch, Simon Finch, Spencer Finch, Natalie Fineman, Jim Finlayson, Lauren Finlayson, Adam Finn, Joanne Finn, Dylan Finnerty, Clare Finney, Deborah Finucane, Sofia Fiouni, Jo Fiquet, Promise Firi, James Fisher, Neil Fisher, Daniel Fishman, Krystofer Fishwick, Carolyn Fitton, Felicity Fitzgerald, Fiona Fitzgerald, Karen Fitzjohn, Jan Flaherty, Michael Flanagan, Charles Flanders, Nikolaos Flaris, Gail Fleming, Julie Fleming, Lucy Fleming, Paul Fleming, William Flesher, Alison Fletcher, Anna Fletcher, Jonathan Fletcher, Lucy Fletcher, Simon Fletcher, Sophie Fletcher, Fiona Flett, Karen Flewitt, Sarah Flockhart, Christopher Flood, Ian Floodgate, Jonathan Flor, Vincent Florence, Mary Flowerdew, Sharon Floyd, Margaret J Flynn, Rachel Flynn, Claire Foden, Adama Fofana, Georgina Fogarty, Paul Foley, Linda Folkes, Tracey Fong, Daniela M Font, Aiwyne Foo, Jane Foo, Andrew Foot, Helen R Foot, Jayne Foot, Jane Forbes, Amber Ford, Jamie Ford, Imogen Fordham, Jennifer Foreman, Matthew Forester, Mohammad Forkan, Caroline Fornolles, Adam Forrest, Ellie Forsey, Miranda Forsey, Thomas Forshall, Elliot Forster, Abigail Forsyth, Julian Forton, Conrad Foster, Emily Foster, Joseph Foster, Rachel A Foster, Tracy Foster, Angela Foulds, Ian Foulds, Folakemi Fowe, Natasha Fowkes, Emily Fowler, Robert Fowler, Stephen Fowler, Amy Fox, Claire Fox, Heather Fox, Jonathan Fox, Laura Fox, Lauren Fox, Natalie Fox, Olivia Fox, Simon Fox, Sarah-Jane Foxton, Eva Fraile, Rebecca Frake, Alex Francioni, Olesya Francis, Rebecca Francis, Sarah Francis, Theodora Francis-Bacon, Helen Frankland, Jessica Franklin, Siobhan Franklin, Catherine Fraser, Andi Fratila, Sharon Frayling, Martyn Fredlund, Anna Freeman, Carol Freeman, Elaine Freeman, Hannah Freeman, Nicola Freeman, Clare Freer, Eleanor French, Thomas French, Karen Freshwater, Matthew Frise, Renate Fromson, Adam Frosh, John Frost, Victoria Frost, Oliver Froud, Rachel Frowd, Arun Fryatt, Andrzej Frygier, Bridget Fuller, Liz Fuller, Lucy Fuller, Tracy Fuller, Duncan Fullerton, Carrie Fung, Gayle Fung, Sarah Funnell, John Furness, Andrew Fyfe, Nytianandan G, Elizabeth Gabbitas, Claire Gabriel, Zoë Gabriel, Hadiza Gachi, Sophie Gaffarena, Sarah Gage, Joshua Gahir, Sarveen Gajebasia, Katarzyna Gajewska-Knapik, Babita Gajmer, Zacharoula Galani, Christopher Gale, Hugo Gale, Linda Gale, Rebecca Gale, Swetha Gali, Bernadette Gallagher, Jude Gallagher, Rosie Gallagher, William Gallagher, Feroze Gallam, Joanne Galliford, Catherine Galloway, Chris Galloway, Emma Galloway, Jacqui Galloway, James Galloway, Anna Galvin, Victoria Galvis, Gareth Gamble, Laura Gamble, Liz Gamble, Brian Gammon, Chien N Gan, Muhammad B Ganaie, Jaikumar Ganapathi, Ramesh Ganapathy, Kaminiben Gandhi, Sarah Gandhi, Usha Ganesh, Thenugan Ganeshanathan, Saibal Ganguly, Abrar Gani, Pauline Ganley, Ukraina Garcia, Emma-James Garden, Antoni D Gardener, Emma Gardiner, Michael Gardiner, Phil Gardiner, Siobhan Gardiner, Caroline Gardiner-Hill, Jonathan Gardner, Louis Gardner, Mark Garfield, Atul Garg, Isha Garg, Nathan Garlick, Daniel Garner, Justin Garner, Lucie Garner, Zoe Garner, Rosaline Garr, Kathryn A Garrero, Manisha Gartaula, Florence Garty, Rachel Gascoyne, Hyeriju Gashau, Aoife Gatenby, Erin Gaughan, Alok Gaurav, Mariana Gavrila, Jane Gaylard, Sophie Gayle, Catherine Geddie, Ian Gedge, Sarah Gee, Fartuun Geele, Kalaichelvi Geerthan, Minnie Gellamucho, Karzan Gelly, Leila Gelmon, Sandra Gelves-Zapata, Gemma Genato, Neal Gent, Susan Gent, Natalie Geoghegan, Aparna George, Bini George, Sam George, Susan George, Tina George, Valerie P George, Simon Georges, Domonique Georgiou, Peter Gerard, Leigh Gerdes, Louise Germain, Helen Gerrish, Abel Getachew, Louise Gethin, Siobhan Gettings, Hisham Ghanayem, Bijan Ghavami Kia, Shaista Ghazal, Anca Gherman, Alison Ghosh, Dipansu Ghosh, Justin Ghosh, Subhamay Ghosh, Sarra Giannopoulou, Malick Gibani, Chris Gibb, Ben Gibbison, Kerry Gibbons, Alex Gibson, Bethan Gibson, Jamie Gibson, Kimberley Gibson, Kirsty Gibson, Sian Gibson, Mary Gigi, Cat Gilbert, Jeanette Gilbert, Kayleigh Gilbert, Benjamin Giles, James Gilham, Mandy Gill, Lynne Gill, Paul Gillen, Annelies Gillesen, Katherine Gillespie, Elizabeth Gillham, Andrew Gillian, Deborah Gilliland, Robert Gillott, Danielle Gilmour, Kate Gilmour, Lesley Gilmour, Louis Ginn, Franciscus Ginting, Theodora Giokanini-Royal, Anna Gipson, Barbie Giri, Joanna Girling, Rhian Gisby, Angelena Gkioni, Aikaterini Gkoritsa, Effrossyni Gkrania-Klotsas, Amy Gladwell, James Glanville, Jessica Glasgow, Susannah Glasgow, Jon Glass, Lynn Glass, Sharon Glaysher, Lisa Gledhill, Eleanor Glenday, Ana Glennon, Jodie Glossop, John Glover, Kyle Glover, Michelle Glover, Jan Glover Bengtsson, Deborah Glowski, Sharon Glynn, Chevanthy Gnanalingam, Julie Goddard, Wendy Goddard, Emily Godden, Jo Godden, Sarah Godlee, Emma Godson, Gillian Godwin, Sukanya Gogoi, Aiky Goh, Manjinder Gohel, Rebeca Goiriz, Sriya Gokaraju, Raphael Goldacre, Arthur Goldsmith, Portia Goldsmith, Darren Gomersall, Lucia Gomez, Raquel Gomez-Marcos, Ali Gondal, Celia Gonzalez, Jack Goodall, Vicky Goodall, Bob Goodenough, Anna Goodfellow, Laura Goodfellow, James Goodlife, Camelia Goodwin, Elizabeth Goodwin, Jayne Goodwin, Paula Goodyear, Rajiv Gooentilleke, Michelle Goonasekara, Sheila Gooseman, Shameer Gopal, Chris Gordon, Sally Gordon, Robin Gore, Hugh Gorick, Caitlin Gorman, Claire Gorman, Stuart Gormely, Maria Gorniok, Diana Gorog, Michelle Gorst, Thomas Gorsuch, Jayshreebahen Gosai, Rebecca Gosling, Sally Gosling, Georgina Gosney, Vanessa Goss, Dzintars Gotham, Naomi Gott, Elizabeth Goudie, Nicole Gould, Susan Gould, Charlotte Goumalatsou, Lysander Gourbault, Abha Govind, Rajesh Govindan, Sharon Gowans, Girish Gowda, Rohit Gowda, Hannah Gower, Pankaj Goyal, Sunil Goyal, Sushant Goyal, Cheryl Graham, Clive Graham, Jonathan Graham, Justin Graham, Libby Graham, Rachel Graham, Sharon Graham, Matthew Graham-Brown, Julia Grahamslaw, Gianluca Grana, Tracyanne Grandison, Louis Grandjean, Alison Grant, Ann Grant, David Grant, Kirstie Grant, Matthew Grant, Pauleen Grant, Rhys Gravell, Jenny Graves, Alasdair Gray, Catherine Gray, Georgina Gray, Glaxy Gray, Jackie Gray, Karen Gray, Nicola Gray, Roxanne Gray, Sebastian Gray, Alan Grayson, Fiona Greaves, Paul Greaves, Alastair Green, Amy Green, Amy S Green, Charlotte Green, Christopher A Green, David Green, Frederick Green, Joel Green, Marie Green, Nicola Green, Stacey Green, Diarra Greene, Philippa Greenfield, Alan Greenhalgh, Daniel Greenwood, Sandra Greer, James Gregory, Jane Gregory, Katie Gregory, Tamsin Gregory, Jill Greig, Julia Greig, Rebecca Grenfell, Teena Grenier, Jack Grenville, Jo Gresty, Susan Grevatt, Glaxy Grey, Samuel Gribben, Andrew Gribbin, Amy Gribble, Natasha Grieg, Douglas Grieve, Ben Griffin, Denise Griffin, Mel Griffin, Sian Griffith, Andrew Griffiths, Daniel Griffiths, David Griffiths, Donna Griffiths, Isabel Griffiths, Mark Griffiths, Nicola Griffiths, Oliver Griffiths, Sandra Griffiths, Sarah Griffiths, Scott Griffiths, Yvonne Griffiths, Sofia Grigoriadou, Steph Grigsby, Paul Grist, Evelina Grobovaite, Dorothy Grogono, Clarissa Grondin, Rachel Groome, Pauline Grose, Liliana Grosu, Jenny Grounds, Margaret Grout, Helen Grover, Jayne Groves, Neil Grubb, Julie Grundy, Francesca Guarino, Sharada Gudur, Jacinta Guerin, Sharazeq 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Hale, Jennie Hale, Carmel Halevy, Paul Halford, William Halford, Alaina Halim, Alistair Hall, Anthony Hall, Claire Hall, Elizabeth Hall, Fiona Hall, Helen Hall, Jennifer Hall, Kathryn Hall, Laura Hall, Jan Hallas, Kyle Hallas, Charles Hallett, Jackie Halliday, Akmal Hallman, Heather Halls, Maryam Hamdollah-Zadeh, Ifedadepo A Hamed-Adekale, Bilal Hameed, Mohammed Hameed, Raph L Hamers, Imran Hamid, Mohamad Hamie, Raymond Hamill, Bethany Hamilton, Fergus Hamilton, Gus Hamilton, Leigh Hamilton, Melanie Hamilton, Nicola Hamilton, Sara Hamilton, Ruth Hamlin, Eleanor Hamlyn, Beatrice Hammans, Shirley Hammersley, Kate Hammerton, Bev Hammond, Emily Hammond, Leah Hammond, Sally Hammond, Fiona Hammonds, Ibrahim Hamoodi, Karen Hampshire, James A Hampson, Jude Hampson, Lucy Hampson, Lisa Hamzah, Jenny Han, Ozan Hanci, Sadiyah Hand, Lala Handayani, Jasmine Handford, Soran Handrean, Nina K Handzewniak, Sarah Haney, Vu Thi Kim Hang, Sheharyar Hanif, E Hanison, Esther Hanison, Jennifer Hannah, Amy Hannington, Merhej Hannun, Aidan Hanrath, Helena Hanratty, Daniel Hansen, Anita Hanson, Ashley Hanson, Helen Hanson, Jane Hanson, Kathryn Hanson, Steve Hanson, Ala Haqiqi, Monjurul Haque, Henry Harcourt, Lesley Harden, Zoe Harding, Simon Hardman, Marc Hardwick, Gareth Hardy, Joanna Hardy, Yasmine Hardy, Kumar Haresh, Rachel Harford, Beverley Hargadon, James Hargraves, Carolyn Hargreaves, Alice Harin, Mohammed Haris, Edward Harlock, Paula Harman, Tracy Harman, Mark Harmer, Muhammad A Haroon, Charlie Harper, Heather Harper, James Harper, Peter Harper, Rosemary Harper, Sarah Harrhy, Kate Harrington, Sian Harrington, Yasmin Harrington-Davies, Jade Harris, Jess Harris, John Harris, Laura Harris, Marie-Clare Harris, Nichola Harris, Sophie Harris, David Harrison, Laura Harrison, Melanie Harrison, Olakunbi A Harrison, Rachael Harrison, Rowan Harrison, Susie Harrison, Thomas Harrison, Wendy Harrison, Elizabeth Harrod, Ciaran Hart, Dominic Hart, Jessica Hartley, Lisa Hartley, Rosemary Hartley, Ruth Hartley, Tom Hartley, William Hartrey, Phillipa Hartridge, Stuart Hartshorn, Alice Harvey, Angela Harvey, Anna Harvey, Max Harvey, Catherine Harwood, Helen Harwood, Zoe Harzeli, Brigitte Haselden, Kazi Hashem, Mohammed Hashimm, Tadaaki Hashimoto, Imranullah Hashmi, Jack Haslam, Zena Haslam, Grace Hasnip, Adil Hassan, Ali Hassan, Amro Hassan, Awab Hassan, Zeinab Hassan, Sapna Hassasing, Jane Hassell, Philip Hassell, Alex Hastings, Bethany Hastings, Janice Hastings, Sarah Hathaway-Lees, Jonathan Hatton, Jennifer Hau, May Havinden-Williams, Stefan Havlik, Daniel B Hawcutt, Kadean Hawes, Liz Hawes, Nicola Hawes, Lydia Hawker, Annie Hawkins, Joe Hawkins, Nancy Hawkins, W John Hawkins, Dan Hawley, Ed Hawley-Jones, Edward Haworth, Alasdair W Hay, Cathy Hay, Amna Hayat, Jamal Hayat, Mohamed-Riyal Hayathu, Anne Hayes, Jonas Hayes, Kate Hayes, Melony Hayes, Fiona Hayes, Patrick Hayle, Chloe Haylett, Antara Hayman, Melanie Hayman, Matthew Haynes, Richard Haynes, Rachel Hayre, Carole Hays, Sarah Haysom, James Hayward, Patrick Haywood, Hazel Haywood Hasford, Tracy Hazelton, Phoebe Hazenberg, Zhengmai He, Elizabeth Headon, Carrie Heal, Brendan Healy, Jessica L Healy, Amy Hearn, David Heasman, Angela Heath, Debbie Heath, Rowan Heath, Diane Heaton, Adam Heavens, Kerry Hebbron, Catherine Heckman, Gemma Hector, Sadie Heddon, Andy Hedges, Katrine Hedges, Cheryl Heeley, Elaine Heeney, Richard Heinink, Rajdeep Heire, Ingvild Helgesen, Joanne Hemingway, Ulla Hemmila, Beth Hemmings, Scott Hemphill, Deborah Hemsley, Abigail Henderson, Eilidh Henderson, Jennifer Henderson, Steven Henderson, Joanne Henry, Karol Henry, Lavinia Henry, Margo Henry, Natalie Henry, David Henshall, Gillian Herdman, Rosaleen Herdman-Grant, Morag Herkes, Lucas E Hermans, Fe Marie Hernandez, Emma Heron, Lisa Heron, William Herrington, Emilia Heselden, Peta Heslop, Tracey Heslop, Simon Hester, Emily Hetherington, Joseph Hetherington, Chamila Hettiarachchi, Pramodh Hettiarachchi, Hayley Hewer, John Hewertson, 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Woolley, Daniel Woosey, Dan Wootton, Joanne Wootton, Daniel Worley, Stephy Worton, Jonathan Wraight, Maria Wray, Kim Wren, Lynn Wren, Caroline Wrey Brown, Catherine Wright, Demi Wright, Francesca Wright, Holly Wright, Imogen Wright, Lianne Wright, Rachel Wright, Sarah Wright, Stephanie Wright, Tim Wright, Caroline Wroe, Hannah Wroe, Henry Wu, Peishan Wu, Pensee Wu, Jonathan Wubetu, Fitria Wulandari, Retno Wulandari, Subie Wurie, Craig Wyatt, Frederick Wyn-Griffiths, Inez Wynter, Bindhu Xavier, Arnold Xhikola, Bingru E Xia, Zhongyang Xia, Effua Yacoba, Santosh Yadav, Masseh Yakubi, May Yan, Yuuki Yanagisawa, Freda Yang, Yingjia Yang, Michael Yanney, Woei Lin Yap, Nabil Yaqoob, Salima Yasmin, Bryan Yates, David Yates, Edward Yates, Helen Yates, Thomas Yates, Mark Yates, Jessica Ye, Charlotte Yearwood Martin, Khin Yein, Fiona Yelnoorkar, Lam Minh Yen, Alastair Yeoh, Chun Yu Yeung, Peter Yew, Durgesh Yewatkar, Laura Ylquimiche Melly, Inez Ynter, H Yong, Jemma Yorke, Jasmine Youens, Abdel Younes Ibrahim, Eoin Young, Gail Young, Louise Young, Asfand Yousafzar, Sajeda Youssouf, Ahmed Yousuf, Hartantri Yovita, Chrissie Yu, Jack S J Yuan, Nindya Yufaniaputri, Bernard Yung, Daniel Yusef, Said Yusef, Intekhab Yusuf, Anna-Sophia Zafar, Silvia Zagalo, Su Zaher, Aqsa Zahoor, Mahrukh Zainab, Thornton Zak, Kareem Zaki, Nabhan Zakir, Kasia Zalewska, Ane Zamalloa, Mohsin Zaman, Shakir Zaman, Julie Zamikula, Louise Zammit, Marie Zammit-Mangion, Marcelina Zawadzka, Mohammed Zayed, Esther Zebracki, Daniel Zehnder, Lisa Zeidan, Darius Zeinali, Jing Zhang, Xiaobei Zhao, Dongling Zheng, Doreen Zhu, Madiha Zia, Omar Zibdeh, Rabia Zill-E-Huma, Ei Thankt Zin, Eva Zincone, Garikai Zindoga, Eleanor Zinkin, Vivian Zinyemba, Christos Zipitis, Letizia Zitter, Arkadiusz Zmierczak, Garazi Zubikarai, Azam Zubir, Naz Zuhra, Rasha Zulaikha, Sabrina Zulfikar, Carol Zullo, Ana Zuriaga-Alvaro, University of St Andrews. Infection and Global Health Division, University of St Andrews. School of Medicine, and Group, RECOVERY Collaborative
Subjects: Adult, Male, Hypoxia/etiology, SARS-CoV-2, COVID-19, 3rd-DAS, General Medicine, Adrenal Cortex Hormones/therapeutic use, AC, Dexamethasone/therapeutic use, Hospitals, Oxygen, Treatment Outcome, SDG 3 - Good Health and Well-being, MCP, Humans, Female
Abstract: Background Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group. Methods This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation Findings Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen (eight [1%]) or simple oxygen only (1264 [99%]) were randomly allocated to receive usual care plus higher dose corticosteroids (659 patients) versus usual care alone (613 patients, of whom 87% received low-dose corticosteroids during the follow-up period). Of those randomly assigned, 745 (59%) were in Asia, 512 (40%) in the UK, and 15 (1%) in Africa. 248 (19%) had diabetes and 769 (60%) were male. Overall, 123 (19%) of 659 patients allocated to higher dose corticosteroids versus 75 (12%) of 613 patients allocated to usual care died within 28 days (rate ratio 1·59 [95% CI 1·20–2·10]; p=0·0012). There was also an excess of pneumonia reported to be due to non-COVID infection (64 cases [10%] vs 37 cases [6%]; absolute difference 3·7% [95% CI 0·7–6·6]) and an increase in hyperglycaemia requiring increased insulin dose (142 [22%] vs 87 [14%]; absolute difference 7·4% [95% CI 3·2–11·5]). Interpretation In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared with usual care, which included low-dose corticosteroids. The RECOVERY trial continues to assess the effects of higher dose corticosteroids in patients hospitalised with COVID-19 who require non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation. Funding UK Research and Innovation (Medical Research Council), National Institute of Health and Care Research, and Wellcome Trust.
Published: 2023
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41. A Component-Based Simplex Architecture for High-Assurance Cyber-Physical Systems.

Author: Dung T. Phan, Junxing Yang, Matthew Clark, Radu Grosu, John D. Schierman, Scott A. Smolka, and Scott D. Stoller
Published: 2017
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42. Sounds of Health

Author: Matthew Clark and Afsaneh Doryab
Subjects: Human-Computer Interaction, Computer Networks and Communications, Hardware and Architecture
Abstract: This paper explores the feasibility of using sonification in delivering and communicating health and wellness status on personal devices. Ambient displays have proven to inform users of their health and wellness and help them to make healthier decisions, yet, little technology provides health assessments through sounds, which can be even more pervasive than visual displays. We developed a method to generate music from user preferences and evaluated it in a two-step user study. In the first step, we acquired general healthiness impressions from each user. In the second step, we generated customized melodies from music preferences in the first step to capture participants' perceived healthiness of those melodies. We deployed our surveys for 55 participants to complete on their own over 31 days. We analyzed the data to understand commonalities and differences in users' perceptions of music as an expression of health. Our findings show the existence of clear associations between perceived healthiness and different music features. We provide useful insights into how different musical features impact the perceived healthiness of music, how perceptions of healthiness vary between users, what trends exist between users' impressions, and what influences (or does not influence) a user's perception of healthiness in a melody. Overall, our results indicate validity in presenting health data through personalized music models. The findings can inform the design of behavior management applications on personal and ubiquitous devices.
Published: 2022
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43. Autonomous quadrotor terrain-following with a laser rangefinder and gimbal system.

Author: Matthew Clark and Robert C. Roberts
Published: 2017
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44. Reliability of the Pediatric Specific Musculoskeletal Ultrasound Scoring Systems for the Elbow, Wrist, and Finger Joints

Author: Patricia Vega-Fernandez, Ysabella Esteban, Edward Oberle, Jean-Philippe Proulx-Gauthier, Matthew Clark, Susan Shenoi, Akaluck Thatayatikom, Heather Benham, Emily J. Brunner, Leandra Woolnough, Michael Henrickson, Laura R. Pratt, Deirdre De Ranieri, Sarah Hoffmann, Ginger Janow, Hulya Bukulmez, Mekibib Altaye, Amy Cassedy, Tracy V. Ting, and Johannes Roth
Subjects: Rheumatology, Immunology, Immunology and Allergy
Abstract: ObjectiveMusculoskeletal ultrasound (MSUS) is increasingly being used in the evaluation of pediatric musculoskeletal diseases. In order to provide objective assessments of arthritis, reliable MSUS scoring systems are needed. Recently, joint-specific scoring systems for arthritis of the pediatric elbow, wrist, and finger joints were proposed by the Childhood Arthritis and Rheumatology Research Alliance (CARRA) MSUS workgroup. This study aimed to assess the reliability of these scoring systems when used by sonographers with different levels of expertise.MethodsMembers of the CARRA MSUS workgroup attended training sessions for scoring the elbow, wrist, and finger. Subsequently, scoring exercises of B mode and power Doppler (PD) mode still images for each joint were performed. Interreader reliability was determined using 2-way single-score intraclass correlation coefficients (ICCs) for synovitis and Cohenfor tenosynovitis.ResultsSeventeen pediatric rheumatologists with different levels of MSUS expertise (1-15 yrs) completed a 2-hour training session and calibration exercise for each joint. Excellent reliability (ICC > 0.75) was found after the first scoring exercise for all the finger and elbow views evaluated on B mode and PD mode, and for all of the wrist views on B mode. After a second training session and a scoring exercise, the wrist PD mode views reached excellent reliability as well.ConclusionThe preliminary CARRA MSUS scoring systems for assessing arthritis of the pediatric elbow, wrist, and finger joints demonstrate excellent reliability among pediatric MSUS sonographers with different levels of expertise. With further validation, this reliable joint-specific scoring system could serve as a clinical tool and scientific outcome measure.
Published: 2022
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45. 'The form of the formless' : a hermeneutical exegesis of the Tripartite Tractate from Nag Hammadi Codex I

Author: Brewer, Matthew Clark
Subjects: 800, ML Literature on music, PN Literature (General), B Philosophy (General), BL Religion
Abstract: This is a theological and philosophical exegesis of the largest, and most systematic, extant Valentinian text: the Tripartite Tractate. While focusing on the detail of that text, there ever remains a wider concern for the fundamental orientation of the tradition within which it stands, particularly as represented by the other Valentinian texts of the Nag Hammadi Library. My intention in this study is to begin a hermeneutical engagement with the Valentinian tradition as embodied in the tractate . I have followed Ricoeur's method of entering the world of the text in order to discover its intentions and concerns, on its own terms and in its own language; to read from within it in order to articulate its meaning in a way that opens up its world to those reading it in an environment that is radically different from its original one. The study demonstrates why 'nonduality' is the only adequate characterisation of Valentinian Christianity.
Published: 2000
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46. NASA ESDS Citizen Science Data Working Group

Author: Helen M Amos, Travis Andersen, Anthony Arendt, Jarrett Byrnes, Matthew Clark, Lisa Dallas, Narendra Das, Prakash Doraiswamy, Robert Levy, Tamlin Pavelsky, David Overoye, Hampapuram Ramapriyan (Rama), Leonardo Salas, William Teng, John Volkens, Yaxing Wei, and Bruce E Wilson
Subjects: Documentation And Information Science
Abstract: This document provides guidelines for legal, policy, and ethical issues; standards for citizen science data collection and management; information on ensuring usability of citizen science data and communication regarding its use; and best practices for long-term archival of citizen science data.Section1 contains a detailed discussion of policy, ethical, and legal considerations influencing citizen science data collection. Section 2 considers standards for documentation, including documentation of instrumentation, procedures, and the data itself. It concludes with a discussion of how citizen science data should be attributed. Section 3 provides guidance about how to ensure citizen science data are collected and stored in a useable way. It also considers how NASA and data producers should notify the scientific community, including citizen scientists and the public, about citizen science datasets and the scientific conclusions reached using them. Finally, Section 4 provides detailed information regarding what should be archived from projects using a citizen science approach, including data and code. It provides guidance about archive location, process, and timeframe, as well as information about data access and distribution services provided by NASA that may be relevant to data producers working with citizen scientists.
Published: 2020

47. Guiding Kidney Transplantation Candidates for Effective Weight Loss: A Clinical Cohort Study

Author: Aleksandra Kukla, Tayyab Diwan, Byron H. Smith, Maria L. Collazo-Clavell, Elizabeth C. Lorenz, Matthew Clark, Karen Grothe, Aleksandar Denic, Walter D. Park, Sukhdeep Sahi, Carrie A. Schinstock, Hatem Amer, Naim Issa, Andrew J. Bentall, Patrick G. Dean, Yogish C. Kudva, Manpreet Mundi, and Mark D. Stegall
Subjects: General Medicine
Published: 2022
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48. Enhanced climatology of large hail in the UK: Radar-derived diurnal cycle and storm mode

Author: Henry Wells, John Hillier, Freya Garry, Nick Dunstone, Huili Chen, Abdullah Kahraman, William Keat, and Matthew Clark
Abstract: Large hail, with a diameter of at least 20 mm, is a hazard associated with severe convective storms (SCS) that can cause significant damage. Understanding of atmospheric environments conducive to large hail is underpinned by catalogues of past events. Because of the small footprint of hail events, these often rely on crowdsourced reports. In the UK, the relative rarity of large hail and low public awareness of SCS hazards makes obtaining a complete set of reports difficult, and in many cases the precise time of the hail is not recorded. In this study, the two major databases of UK large hail reports are merged for the first time. Composite radar reflectivity data are used to verify and enhance 260 reports since 2006. Time of the hail and the basic storm mode (isolated, clustered or linear) are visually estimated from animations. Compared to the UK’s most severe historic hailstorms (1800–2004), our quality controlled climatology of all sizes of large hail shows a diurnal cycle with a slightly broader peak. Around 55% of large hail events are associated with isolated cells, while 34% have supercellular characteristics, a much lower proportion than found in the USA. The full event set (1979–2022), comprising over 850 reports, is used to update the seasonal, spatial and size distributions of large hail in the UK. We intend that this hail event set forms part of a multi-hazard analysis of UK SCS, also including tornadoes and extreme rainfall, and its relationship to background atmospheric conditions. The effect of climate change on UK SCS will be investigated through past and future trends in these background conditions.
Published: 2023
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49. Fentanyl Toxicity Related to Concomitant Use of Ciprofloxacin and its Effects as a CYP3A4 Inhibitor

Author: Michael Tang, Matthew Clark, Akhila Reddy, and Eduardo Bruera
Subjects: Anesthesiology and Pain Medicine, Neurology (clinical), General Nursing
Published: 2023
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50. Personalization in Circadian Rhythm-Based Event Scheduling

Author: Prachi Sadekar, Jackson Baitinger, Sean Conway, Matthew Clark, and Afsaneh Doryab
Published: 2023
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