214 results on '"Matteo Martini"'
Search Results
2. Inpatient treatments for adults with anorexia nervosa: a systematic review of literature
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Federica Toppino, Matteo Martini, Paola Longo, Inês Caldas, Nadia Delsedime, Raffaele Lavalle, Francesco Raimondi, Giovanni Abbate-Daga, and Matteo Panero
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Anorexia nervosa ,Inpatient ,Hospitalization ,Treatment ,Eating disorders ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Purpose Anorexia nervosa (AN) is a mental disorder for which hospitalization is frequently needed in case of severe medical and psychiatric consequences. We aim to describe the state-of-the-art inpatient treatment of AN in real-world reports. Methods A systematic review of the literature on the major medical databases, spanning from January 2011 to October 2023, was performed, using the keywords: “inpatient”, “hospitalization” and “anorexia nervosa”. Studies on pediatric populations and inpatients in residential facilities were excluded. Results Twenty-seven studies (3501 subjects) were included, and nine themes related to the primary challenges faced in hospitalization settings were selected. About 81.48% of the studies detailed the clinical team, 51.85% cited the use of a psychotherapeutic model, 25.93% addressed motivation, 100% specified the treatment setting, 66.67% detailed nutrition and refeeding, 22.22% cited pharmacological therapy, 40.74% described admission or discharge criteria and 14.81% follow-up, and 51.85% used tests for assessment of the AN or psychopathology. Despite the factors defined by international guidelines, the data were not homogeneous and not adequately defined on admission/discharge criteria, pharmacological therapy, and motivation, while more comprehensive details were available for treatment settings, refeeding protocols, and psychometric assessments. Conclusion Though the heterogeneity among the included studies was considered, the existence of sparse criteria, objectives, and treatment modalities emerged, outlining a sometimes ambiguous report of hospitalization practices. Future studies must aim for a more comprehensive description of treatment approaches. This will enable uniform depictions of inpatient treatment, facilitating comparisons across different studies and establishing guidelines more grounded in scientific evidence. Level of evidence Level I, systematic review.
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- 2024
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3. Bispecific aptamer-decorated and light-triggered nanoparticles targeting tumor and stromal cells in breast cancer derived organoids: implications for precision phototherapies
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Simona Camorani, Alessandra Caliendo, Elena Morrone, Lisa Agnello, Matteo Martini, Monica Cantile, Margherita Cerrone, Antonella Zannetti, Massimo La Deda, Monica Fedele, Loredana Ricciardi, and Laura Cerchia
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Aptamer ,EGFR ,PDGFRβ ,Dual targeting ,Nanomedicine ,Patient-derived cancer organoids ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Based on the established role of cancer-stroma cross-talk in tumor growth, progression and chemoresistance, targeting interactions between tumor cells and their stroma provides new therapeutic approaches. Dual-targeted nanotherapeutics selectively acting on both tumor and stromal cells may overcome the limits of tumor cell-targeting single-ligand nanomedicine due to the complexity of the tumor microenvironment. Methods Gold-core/silica-shell nanoparticles embedding a water-soluble iridium(III) complex as photosensitizer and luminescent probe (Iren-AuSiO2_COOH) were efficiently decorated with amino-terminated EGFR (CL4) and PDGFRβ (Gint4.T) aptamers (Iren-AuSiO2_Aptamer). The targeting specificity, and the synergistic photodynamic and photothermal effects of either single- and dual-aptamer-decorated nanoparticles have been assessed by confocal microscopy and cell viability assays, respectively, on different human cell types including mesenchymal subtype triple-negative breast cancer (MES-TNBC) MDA-MB-231 and BT-549 cell lines (both EGFR and PDGFRβ positive), luminal/HER2-positive breast cancer BT-474 and epidermoid carcinoma A431 cells (only EGFR positive) and adipose-derived mesenchymal stromal/stem cells (MSCs) (only PDGFRβ positive). Cells lacking expression of both receptors were used as negative controls. To take into account the tumor-stroma interplay, fluorescence imaging and cytotoxicity were evaluated in preclinical three-dimensional (3D) stroma-rich breast cancer models. Results We show efficient capability of Iren-AuSiO2_Aptamer nanoplatforms to selectively enter into target cells, and kill them, through EGFR and/or PDGFRβ recognition. Importantly, by targeting EGFR+ tumor/PDGFRβ+ stromal cells in the entire tumor bulk, the dual-aptamer-engineered nanoparticles resulted more effective than unconjugated or single-aptamer-conjugated nanoparticles in either 3D spheroids cocultures of tumor cells and MSCs, and in breast cancer organoids derived from pathologically and molecularly well-characterized tumors. Conclusions Our study proposes smart, novel and safe multifunctional nanoplatforms simultaneously addressing cancer-stroma within the tumor microenvironment, which are: (i) actively delivered to the targeted cells through highly specific aptamers; (ii) localized by means of their luminescence, and (iii) activated via minimally invasive light, launching efficient tumor death, thus providing innovative precision therapeutics. Given the unique features, the proposed dual targeted nanoformulations may open a new door to precision cancer treatment.
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- 2024
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4. Role of parental educational level as psychosocial factor in a sample of inpatients with anorexia nervosa and bulimia nervosa
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Francesco Bevione, Matteo Martini, Paola Longo, Federica Toppino, Alessandro Musetti, Laura Amodeo, Giovanni Abbate-Daga, and Matteo Panero
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eating disorders ,eating psychopathology ,anorexia nervosa ,psychosocial risk factors ,parental educational level ,Psychology ,BF1-990 - Abstract
IntroductionEvidence on parental educational level (PEL) as a risk factor for Eating Disorders (EDs) is mixed, and no study has assessed its role in relation to the compliance and outcomes of treatments in EDs. Further, no study differentiated from the educational level of mothers and fathers, nor considered the possible mediation of perfectionism in fostering EDs.MethodsA clinical sample of 242 first-ever admitted inpatients with EDs provided information on PEL and completed the following questionnaires: the Eating Disorder Examination Questionnaire (EDE-Q) and the Frost Multidimensional Perfectionism Scale (F-MPS). Clinicians also provided information on the Hamilton Rating Scale for Anxiety (HAM-A) and the Hamilton Rating Scale for Depression (HAM-D) for each participant.ResultsIndividuals with high PEL (whether mothers, fathers, or both parents) showed significantly higher scores on depressive symptoms and lower on parental criticism, were younger, had an earlier age of onset, had fewer years of illness, more were students and employed, and fewer had offspring. Individuals with fathers or both parents with high educational levels suffered more from Anorexia Nervosa rather than Bulimia Nervosa, had a longer length of stay during the current hospitalization, had less dietary restraint, and had higher personal standards. Individuals with mothers with high educational levels showed a lower rate of previous substance or alcohol addiction. Personal standards partially mediated the relationship between higher PEL and lower dietary restraint.DiscussionPEL emerged to be a twofold psychosocial risk factor, being associated with higher depressive symptoms and a longer length of stay, but also with a shorter duration of illness and better scholar and working involvement. Higher PEL was related to higher personal standards but not to global perfectionism. Patterns of eating psychopathology emerged based on the high PEL of mothers or fathers.
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- 2024
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5. The Clinical and Psychopathological Profile of Inpatients with Eating Disorders: Comparing Vomiting, Laxative Abuse, and Combined Purging Behaviors
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Matteo Panero, Francesco Bevione, Ilaria Sottosanti, Paola Longo, Federica Toppino, Carlotta De Bacco, Giovanni Abbate-Daga, and Matteo Martini
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anorexia nervosa ,eating disorders ,purging behavior ,hospitalization ,Medicine - Abstract
Background/Objectives: The previous literature on purging behavior in eating disorders (EDs) suggests an overall more complicated clinical picture for individuals with this symptomatology. So far, no studies have analyzed the possible differences between the specific types of purging among ED inpatients. Methods: A clinical sample of 302 inpatients with EDs was classified according to no purging behaviors, vomiting, the abuse of laxatives, and both vomiting and the abuse of laxatives. Participants completed the following questionnaires: the Eating Disorder Examination Questionnaire (EDE-Q), Frost Multidimensional Perfectionism Scale (F-MPS), State–Trait Anxiety Inventory (STAI), and Beck Depression Inventory (BDI). Clinical information was collected for each individual. Results: Significant differences in the four groups were evidenced in age (p < 0.001), years of illness (p < 0.001), BMI at discharge (p < 0.001), STAI state anxiety (p < 0.001), STAI trait anxiety (p < 0.001), BDI (p < 0.001), EDE-Q eating concerns (p < 0.001), EDE-Q shape concerns (p < 0.001), EDE-Q weight concerns (p < 0.001), EDE-Q global score (p < 0.001), and F-MPS parental criticism (p < 0.001). ED inpatients with purging behaviors were older, had a longer duration of illness, higher parental criticism, and worse general and eating psychopathology. No differences emerged between the specific types of purging behavior. Conclusions: Purging behavior is a marker of severity in EDs independently of the specific type of purging. The appearance of any purging behavior must be regarded as a considerable red flag and be followed by an intensification of the cure.
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- 2024
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6. Disentangling the effects of near-infrared light stimulation and exercise on cognitive function in fNIRS studies
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Matteo Martini and Natalia Arias
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Functional near-infrared spectroscopy (fNIRS) studies often aim to measure changes in the brain's hemodynamic response in relation to a specific intervention. We recently showed how a fNIRS device could induce photobiomodulatory effects on cognition by using its near-infrared (NIR) light. However, so far, fNIRS research has overlooked the stimulatory potential intrinsic to this technique. The work by Kuwamizu et al. (2023) on pupil dynamics during exercise is no exception. Here, we suggest a fix to their experimental design, which could be taken into account in other fNIRS studies, to guarantee an adequate level of control for possible unconsidered photobiomodulatory effects.
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- 2024
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7. The Nepean Belief Scale (NBS) as a tool to investigate the intensity of beliefs in anorexia nervosa: psychometric properties of the Italian version
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Arianna Sciarrillo, Francesco Bevione, Marta Lepora, Federica Toppino, Maria Carla Lacidogna, Nadia Delsedime, Matteo Panero, Matteo Martini, Giovanni Abbate Daga, and Antonio Preti
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Insight ,Awareness of illness ,Anorexia nervosa/diagnosis ,Beliefs ,Conviction ,Psychometrics/methods ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background People with anorexia nervosa (AN) show a peculiar impairment of insight regarding their condition, often manifesting a denial of extreme emaciation and sometimes hiding or underreporting socially undesirable abnormal eating patterns. Sometimes the intensity of the beliefs held by patients with AN reach a delusional intensity. Objectives In this study, the Italian version of the Nepean Belief Scale was applied to a sample of patients diagnosed with AN to investigate the intensity of their beliefs and convictions and its clinical correlates. Methods The Nepean Belief Scale (NBS) was translated and adapted to Italian and applied to a sample of patients diagnosed with AN based on the Structured Clinical Interview for DSM-5 (SCID-5). Results The Italian version of the 5-item NBS showed excellent reliability. Convergent validity was proved by negative association with levels of insight measured with the Schedule for the Assessment of Insight in Eating Disorders. Beliefs of delusional intensity were reported by 10% of participants. Those with a greater intensity of beliefs, either overvalued or delusional ideas, were more likely to report poorer general cognitive performances on the Montreal Cognitive Assessment. No association was observed between NBS score and age, body mass index, symptoms of eating disorders, body dissatisfaction, or levels of depression. Fear of weight gain and control seeking were the most often reported themes at the NBS. Conclusions The Italian version of the NBS is a reasonably reliable, valid, and usable tool for the multidimensional assessment of insight in AN. Level of evidence Level III, Evidence obtained from well-designed cohort or case–control analytic studies.
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- 2023
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8. Nasogastric Tube Feeding in Anorexia Nervosa: A Propensity Score-Matched Analysis on Clinical Efficacy and Treatment Satisfaction
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Matteo Martini, Paola Longo, Clara Di Benedetto, Nadia Delsedime, Matteo Panero, Giovanni Abbate-Daga, and Federica Toppino
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enteral feeding ,nasogastric tube ,nutritional rehabilitation ,anorexia nervosa ,eating disorders ,treatment satisfaction ,Nutrition. Foods and food supply ,TX341-641 - Abstract
The choice of a refeeding strategy is essential in the inpatient treatment of Anorexia Nervosa (AN). Oral nutrition is usually the first choice, but enteral nutrition through the use of a Nasogastric Tube (NGT) often becomes necessary in hospitalized patients. The literature provides mixed results on the efficacy of this method in weight gain, and there is a scarcity of studies researching its psychological correlates. This study aims to analyze the effectiveness of oral versus enteral refeeding strategies in inpatients with AN, focusing on Body Mass Index (BMI) increase and treatment satisfaction, alongside assessing personality traits. We analyzed data from 241 inpatients, comparing a group of treated vs. non-treated individuals, balancing confounding factors using propensity score matching, and applied regression analysis to matched groups. The findings indicate that enteral therapy significantly enhances BMI without impacting treatment satisfaction, accounting for the therapeutic alliance. Personality traits showed no significant differences between patients undergoing oral or enteral refeeding. The study highlights the clinical efficacy of enteral feeding in weight gain, supporting its use in severe AN cases when oral refeeding is inadequate without adversely affecting patient satisfaction or being influenced by personality traits.
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- 2024
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9. ANCA-negative EGPA: only eosinophils without vasculitis? Insights from anti-T2 biologics
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Mario Andrea Piga, Paolo Fraticelli, Leonardo Antonicelli, Maria Stella Garritani, Giulia Ghirelli, Matteo Martini, Angelica Di Vincenzo, Maria Giovanna Danieli, Gianluca Moroncini, and Maria Beatrice Bilò
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ANCA ,biologics ,EGPA ,eosinophils ,vasculitis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
The pathogenic role of p-ANCA in eosinophilic granulomatosis with polyangiitis (EGPA) is a long-standing matter of debate. In this work, we report our real-life experience with EGPA patients, treated with biologics targeting type 2 (T2)-eosinophilic inflammation (Mepolizumab, Benralizumab, Dupilumab). Interestingly, we observed EGPA extrarespiratory relapses only in p-ANCA-positive patients (2/5 cutaneous vasculitis, 3/5 constitutional symptoms), with new rise of p-ANCA and normal eosinophil blood count. Notably, revising our cohort with the new ACR 2022 criteria, these five patients were the only ones to satisfy the entry criterion of vasculitis’ defined diagnosis at disease onset. These observations may suggest that biologics, selectively turning off T2 inflammation, may have unmasked p-ANCA exclusive role in the pathogenesis of vasculitis in EGPA. Therefore, we raise the question whether EGPA vasculitis exists only in p-ANCA-positive patients, and whether p-ANCA-negative disease is “only eosinophils without vasculitis”.
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- 2023
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10. Cognitive Impulsivity in Anorexia Nervosa in Correlation with Eating and Obsessive Symptoms: A Comparison with Healthy Controls
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Francesco Bevione, Matteo Martini, Federica Toppino, Paola Longo, Giovanni Abbate-Daga, Annalisa Brustolin, and Matteo Panero
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eating disorders ,anorexia nervosa ,impulsivity ,obsessive symptoms ,eating psychopathology ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Impulsivity in eating disorders (ED) has been historically focused on bingeing–purging symptoms, evidencing lower levels in restricting subtypes. In the recent literature, obsessive–compulsive disorder (OCD) has been described as characterized by high cognitive impulsivity. This specific impulsivity factor has been rarely studied in anorexia nervosa (AN). In this study, 53 inpatients with anorexia nervosa and 59 healthy controls completed the following questionnaires: the Barratt Impulsiveness Scale (BIS-11), the Obsessive–Compulsive Inventory (OCI), the Eating Disorders Inventory—2 (EDI–2), the State–Trait Anxiety Inventory (STAI), and the Beck Depression Inventory (BDI). AN individuals showed significantly increased levels of cognitive instability but no difference in global score and other subscales of impulsivity compared to the healthy controls. Among AN individuals, cognitive instability emerged as being associated with the global score and obsession subscale of the OCI. It was also significantly associated with interoceptive awareness and impulse regulation. Cognitive instability was the main predictor of obsessive thoughts and behaviors in AN. Our study supports the hypothesis of AN as being characterized by high cognitive instability and adds the result that the cognitive domain of impulsivity may be associated with the presence of obsessive symptoms, specifically obsessive thoughts.
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- 2024
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11. UNDERSTANDING FNIRS AS A NEUROMODULATORY TECHNIQUE
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Ana Jiménez-García, Natalia Arias Del Castillo, Jason Waight, and Matteo Martini
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2023
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12. Editorial: Community series in body representation and interoceptive awareness: cognitive, affective, and social implications
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Simona Raimo, Matteo Martini, Cecilia Guariglia, Gabriella Santangelo, Luigi Trojano, and Liana Palermo
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body representation ,body image ,body awareness ,self-perception ,interoception ,sense of body ownership ,Psychology ,BF1-990 - Published
- 2023
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13. Drug self-poisoning in adolescents: A report of 267 cases
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Marco Roversi, Matteo Martini, Antonio Musolino, Mara Pisani, Giorgio Zampini, Leonardo Genuini, Gabriella Bottari, Matteo Di Nardo, Francesca Stoppa, and Marco Marano
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Drug self-poisoining ,Suicidal ,Intoxication ,Paracetamol ,Adolescents ,Toxicology. Poisons ,RA1190-1270 - Abstract
Introduction: The current study aims at describing a sample of adolescents admitted to a tertiary referral pediatric hospital for drug self-poisoning and to identify variables that could explain and predict a higher severity of intoxication. Methods: We retrospectively reviewed the cases of drug self-poisoning in adolescents admitted to the Bambino Gesù Children’s Hospital between January 2014 and June 2022 requiring consultation by the local Pediatric Poison Control Center (PPCC). We reported the type and class of drug ingested and correlated the clinical characteristics of the patients with their Poison Severity Score. Results: The data of 267 patients were reported. Most patients were female (85.8 %), with a median age of 15.8 years at presentation. Half of the patients were symptomatic at admission (44.2 %), and most had at least one psychiatric comorbidity (71.1 %). Most patients were hospitalized (79.6 %), 16.6 % of cases required antidote administration and a minority required intensive care. Most patients received a PSS score of 0 (59.6 %). The most frequently ingested drug was acetaminophen (28.1 %) followed by ibuprofen (10.1 %) and aripiprazole (10.1 %). Antipsychotics as a class were the most abused drugs (33.1 %). The correlation of clinical variables with the PSS showed that older and male patients were more prone to be severely intoxicated. Conclusions: This single-center study identifies the most commonly ingested drugs in a large sample of adolescents with voluntary drug self-poisoning, also showing that older and male patients are more susceptible to severe intoxication.
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- 2023
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14. A review of the low-energy K−-nucleus/nuclei interactions with light nuclei AMADEUS investigations
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Magdalena Skurzok, Michael Cargnelli, Raffaele del Grande, Laura Fabbietti, Carlo Guaraldo, Johann Marton, Paweł Moskal, Kristian Piscicchia, Alessandro Scordo, Michał Silarski, Diana Laura Sirghi, Oton Vazquez Doce, Johann Zmeskal, Sławomir Wycech, Paolo Branchini, Eryk Czerwiński, Xiaolin Kang, Giuseppe Mandaglio, Matteo Martini, Andrea Selce, and Catalina Curceanu
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strangeness ,kaon absorption ,antikaon interactions in nuclear matter ,strong interaction ,cross section ,Physics ,QC1-999 - Abstract
The AMADEUS Collaboration conducts research aimed to experimentally investigate the low-energy K− hadronic interactions with light nuclei like hydrogen, helium, and carbon, in order to provide new constraints to the antikaon-nucleon strong interaction studies in the non-perturbative quantum chromodynamics regime. K− nuclear absorption, both at-rest and in-flight, are explored using the unique low-momentum and monochromatic kaon beam from the DAΦNE collider interacting with the KLOE detector components, a detector characterized by high acceptance and excellent position and momentum resolutions. This paper presents an overview of the AMADEUS results.
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- 2023
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15. Cognitive Neuroscience of Pain
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Vahid Rakhshan, Donald B. Giddon, Milica Prostran, Leonard Khiroug, and Matteo Martini
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Medicine (General) ,R5-920 - Published
- 2023
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16. Near-infrared light spectroscopy and stimulation in cognitive neuroscience: the need for an integrative view?
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Matteo Martini and Natalia Arias
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nirs ,fnirs ,nir ,cognition ,physical exercise ,photobiomodulation ,light therapy ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Near-infrared spectroscopy (NIRS) has been largely used in neuroscience as an alternative non-invasive neuroimaging technique, primarily to measure the oxygenation levels of cerebral haemoglobin. Its portability and relative robustness against motion artefacts made it an ideal method to measure cerebral blood changes during physical activity. Usually referred to as ’functional’ NIRS (fNIRS) when used to monitor brain changes during motor or cognitive tasks, this technique often involves the montage the probes on the forehead of the participants to gauge the neurophysiological underpinning of executive functioning. Other applications of NIRS include other aspects of cerebral hemodynamics such as cerebral pulsatility. However, there is an important aspect that fNIRS studies do not seem to have taken into account so far, which relates to the capacity of near-infrared light to modulate cognitive and psychological processes according to what is known as photobiomodulation (PBM). Hence, drawing on a selection of NIRS and PBM experiments, we argue in favour of an integrative view for NIR-based neuroimaging studies, which should embrace a control for the possible effects of light stimulation, especially when fNIRS is considered to test the effect of an intervention.
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- 2021
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17. Pharmacokinetics of extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide in adolescent and adult patients with asthma
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Piotr Kuna, Joanna Jerzynska, Matteo Martini, Andrea Vele, Irene Barneschi, Fabrizia Mariotti, George Georges, and Giorgia Ciurlia
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adolescents ,asthma ,pharmacodynamics ,pharmacokinetics ,systemic exposure ,triple therapy ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract The single‐inhaler extrafine formulation triple combination beclometasone dipropionate (BDP), formoterol fumarate (FF) plus glycopyrronium bromide (GB) is available for asthma management in adults. Its use in adolescents has not yet been evaluated. This study investigated the pharmacokinetic profile of BDP/FF/GB in adults and adolescents, with the aim of ruling out higher plasma exposure in adolescents compared to adults. In this open‐label, non‐randomized study, patients with asthma aged 12–17 (adolescents) and 18–64 years (adults) self‐administered a single dose of BDP/FF/GB 400/24/50 μg via pressurized metered‐dose inhaler (pMDI). The primary objective was to rule out higher systemic exposure to beclometasone 17‐monopropionate (B17MP; active metabolite of BDP), formoterol, and GB in terms of the area under the plasma concentration‐time curve from 0 to the last quantifiable concentration (AUC0–t) in adolescents versus adults. A total of 40 adolescents and 40 adults entered the study (mean age of 14.8 and 43.6 years, respectively). The primary objective (AUC0–t) was met, with the upper 90% confidence interval of the geometric mean ratio between adolescents and adults
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- 2022
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18. Exploring Caloric Restriction in Inpatients with Eating Disorders: Cross-Sectional and Longitudinal Associations with Body Dissatisfaction, Body Avoidance, Clinical Factors, and Psychopathology
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Matteo Martini, Paola Longo, Tiziano Tamarin, Federica Toppino, Annalisa Brustolin, Giovanni Abbate-Daga, and Matteo Panero
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body image ,dietary restriction ,weight suppression ,binge eating ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Reduction in food intake is an important feature of eating disorders (EDs). However, whereas self-reported cognitive control over food (i.e., dietary restraint) is commonly assessed, we are not aware of any study evaluating the actual reduction in caloric intake (i.e., caloric restriction, CR) and its relationships with psychopathological, clinical, and anamnestic factors in individuals with EDs. In this study, we quantified caloric intake, CR, and weight suppression in 225 ED inpatients and explored significant relationships with self-reported eating symptoms, body dissatisfaction, body avoidance, personality, and affective symptoms. For underweight inpatients (n = 192), baseline predictors of caloric intake and restriction at discharge were assessed through a data-driven approach. CR at admission was significantly related to eating symptomatology, state anxiety, and body image. In regression models, CR, higher BMI, binge-purging symptoms, and the interaction between weight suppression and CR were significantly related to body dissatisfaction. The best psychopathological predictors of caloric intake and restriction at discharge for underweight inpatients were perfectionistic concern over mistakes and state anxiety. These results suggest that caloric restriction is associated to relevant ED features and warrant for a multidimensional assessment of ED psychopathology.
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- 2023
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19. Editorial: Body Representation and Interoceptive Awareness: Cognitive, Affective, and Social Implications
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Simona Raimo, Matteo Martini, Cecilia Guariglia, Gabriella Santangelo, Luigi Trojano, and Liana Palermo
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body representation ,body self-awareness ,bodily self-consciousness ,body image ,interoception ,multiperceptual integration ,Psychology ,BF1-990 - Published
- 2022
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20. The Mu2e Crystal Calorimeter: An Overview
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Nikolay Atanov, Vladimir Baranov, Leo Borrel, Caterina Bloise, Julian Budagov, Sergio Ceravolo, Franco Cervelli, Francesco Colao, Marco Cordelli, Giovanni Corradi, Yuri Davydov, Stefano Di Falco, Eleonora Diociaiuti, Simone Donati, Bertrand Echenard, Carlo Ferrari, Antonio Gioiosa, Simona Giovannella, Valerio Giusti, Vladimir Glagolev, Francesco Grancagnolo, Dariush Hampai, Fabio Happacher, David Hitlin, Matteo Martini, Sophie Middleton, Stefano Miscetti, Luca Morescalchi, Daniele Paesani, Daniele Pasciuto, Elena Pedreschi, Frank Porter, Fabrizio Raffaelli, Alessandro Saputi, Ivano Sarra, Franco Spinella, Alessandra Taffara, Anna Maria Zanetti, and Ren Yuan Zhu
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scintillation ,crystals ,SiPM ,calorimetry ,Physics ,QC1-999 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
The Mu2e experiment at Fermilab will search for the standard model-forbidden, charged lepton flavour-violating conversion of a negative muon into an electron in the field of an aluminium nucleus. The distinctive signal signature is represented by a mono-energetic electron with an energy near the muon’s rest mass. The experiment aims to improve the current single-event sensitivity by four orders of magnitude by means of a high-intensity pulsed muon beam and a high-precision tracking system. The electromagnetic calorimeter complements the tracker by providing high rejection power in muon to electron identification and a seed for track reconstruction while working in vacuum in presence of a 1 T axial magnetic field and in a harsh radiation environment. For 100 MeV electrons, the calorimeter should achieve: (a) a time resolution better than 0.5 ns, (b) an energy resolution
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- 2022
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21. Mu2e Crystal Calorimeter Readout Electronics: Design and Characterisation
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Nikolay Atanov, Vladimir Baranov, Leo Borrel, Caterina Bloise, Julian Budagov, Sergio Ceravolo, Franco Cervelli, Francesco Colao, Marco Cordelli, Giovanni Corradi, Yuri Davydov, Stefano Di Falco, Eleonora Diociaiuti, Simone Donati, Bertrand Echenard, Carlo Ferrari, Antonio Gioiosa, Simona Giovannella, Valerio Giusti, Vladimir Glagolev, Francesco Grancagnolo, Dariush Hampai, Fabio Happacher, David Hitlin, Matteo Martini, Sophie Middleton, Stefano Miscetti, Luca Morescalchi, Daniele Paesani, Daniele Pasciuto, Elena Pedreschi, Frank Porter, Fabrizio Raffaelli, Alessandro Saputi, Ivano Sarra, Franco Spinella, Alessandra Taffara, Anna Maria Zanetti, and Ren-Yuan Zhu
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calorimeter ,front-end ,electronics ,crystals ,SiPM ,MPPC ,Physics ,QC1-999 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
The Mu2e experiment at Fermi National Accelerator Laboratory will search for the charged-lepton flavour-violating neutrinoless conversion of negative muons into electrons in the Coulomb field of an Al nucleus. The conversion electron with a monoenergetic 104.967 MeV signature will be identified by a complementary measurement carried out by a high-resolution tracker and an electromagnetic calorimeter, improving by four orders of magnitude the current single-event sensitivity. The calorimeter—composed of 1348 pure CsI crystals arranged in two annular disks—has a high granularity, 10% energy resolution and 500 ps timing resolution for 100 MeV electrons. The readout, based on large-area UV-extended SiPMs, features a fully custom readout chain, from the analogue front-end electronics to the digitisation boards. The readout electronics design was validated for operation in vacuum and under magnetic fields. An extensive radiation hardness certification campaign certified the FEE design for doses up to 100 krad and 1012 n1MeVeq/cm2 and for single-event effects. A final vertical slice test on the final readout chain was carried out with cosmic rays on a large-scale calorimeter prototype.
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- 2022
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22. Inpatients with severe-enduring anorexia nervosa: Understanding the 'enduringness' specifier
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Enrica Marzola, Matteo Martini, Annalisa Brustolin, and Giovanni Abbate-Daga
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eating disorders ,hospitalization ,quality of life ,severe-enduring ,stages of change ,Psychiatry ,RC435-571 - Abstract
Abstract Background Despite the need for a common definition of severe and enduring anorexia nervosa (SE-AN) with the overarching goal to optimize treatments, this definition still is being debated. Therefore, in this study we conducted an in-depth investigation of the history of AN and its clinical outcomes on inpatients with AN to ascertain the eventual “profiles” for individuals with varying durations of the illness (DOI). Methods We recruited 169 inpatients with AN, grouping them according to DOI:
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- 2021
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23. Pain During Illusory Own Arm Movement: A Study In Immersive Virtual Reality
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Alessandro Zanini, Martina Montalti, Barbara Caola, Antony Leadbetter, and Matteo Martini
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virtual arm ,virtual reality (vr) ,body ownership ,pain threshold ,pain modulation ,multisensory integration ,illusory kinaesthesia ,Medicine - Abstract
Previous studies have demonstrated that the vision of one’s own body, or of external embodied limbs, can lead to pain relieving outcomes. Analgesic effects have also been related to the vision of illusory limb movements. Nonetheless, whether these two processes can be put together to obtain a summatory analgesic effect is not yet clear. The aim of this work was to investigate if it is possible to combine the analgesic effects of looking at one’s own body with those deriving from the illusion that one’s own limb is moving. Thirty-eight healthy participants underwent four visual conditions in immersive virtual reality while their heat pain thresholds were measured. In different conditions the subject watched from a first-person perspective: i) a still virtual arm, ii) a moving virtual arm, iii) a still non-corporeal object, and iv) a moving non-corporeal object. All participants were asked to keep their arms completely still during the visual exposures. After each condition, participants answered questions about their illusory experience. Our results show that the vision of the ‘own’ body significantly increased participants’ pain threshold as compared to the vision of the non-corporeal object. However, no statistically significant analgesic effect of vision of the virtual arm movement was found. The implications and limitations of this study are discussed.
- Published
- 2017
24. E-learning: new strategies and trends
- Author
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Matteo Martini
- Subjects
e-learning ,massive open on-line courses (MOOCs) ,virtual laborato- ries ,flipped classroom ,internet of things ,virtual laboratories ,Education ,Technology - Abstract
The aim of this paper is to present a personal point of view on the possible future trends in distance learning. The starting point of this study is represented by a review of the main innovations in digital and information technologies. This step is necessary since the evolution of distance learning is strictly correlated to the evolution of the technology that can be exploited to increase learning quality. The main arguments discussed in this paper are: massive open on-line courses (MOOCs), flipped classrooms and the evolution of the learning objects based on web and on internet technology. Concerning MOOCs, a critical analysis of the status of this type of learning is necessary to understand their possible evolution and/or their substitution. A huge number of case studies demonstrated the validity of the flipped classroom and the possibility to adopt this approach into e-learning is surely interesting. The last part of the paper is instead dedicated to future technologies like: mobile learning, 3D virtual laboratories and internet of things. As discussed, this latest innovations can push the evolution of distance learning offering real student-centered solutions.
- Published
- 2017
25. The Interaction of Diet and Mitochondrial Dysfunction in Aging and Cognition
- Author
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Aleksandra Kaliszewska, Joseph Allison, Matteo Martini, and Natalia Arias
- Subjects
aging ,cognitive impairment ,diet ,neuroinflammation ,stress ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Aging is inevitable and it is one of the major contributors to cognitive decline. However, the mechanisms underlying age-related cognitive decline are still the object of extensive research. At the biological level, it is unknown how the aging brain is subjected to progressive oxidative stress and neuroinflammation which determine, among others, mitochondrial dysfunction. The link between mitochondrial dysfunction and cognitive impairment is becoming ever more clear by the presence of significant neurological disturbances in human mitochondrial diseases. Possibly, the most important lifestyle factor determining mitochondrial functioning is nutrition. Therefore, with the present work, we review the latest findings disclosing a link between nutrition, mitochondrial functioning and cognition, and pave new ways to counteract cognitive decline in late adulthood through diet.
- Published
- 2021
- Full Text
- View/download PDF
26. Commentary: Mechanical Pain Thresholds and the Rubber Hand Illusion
- Author
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Matteo Martini
- Subjects
pain ,body ownership ,rubber hand illusion ,virtual hand illusion ,embodiment ,Psychology ,BF1-990 - Published
- 2018
- Full Text
- View/download PDF
27. E-learning: nuevas estrategias y tendencias
- Author
-
Matteo Martini
- Subjects
e-learning ,massive open on-line courses (MOOCs) ,laboratorios virtuales ,flipped classroom ,internet de las cosas ,Education ,Technology - Abstract
El objetivo de este trabajo es presentar un punto de vista personal sobre las posibles futuras tendencias en la enseñanza a distancia. El punto de partida de este estudio está representado por una revisión de las principales innovaciones en las tecnologías digitales y de información. Este paso es necesario, ya que la evolución de la enseñanza a distancia está estrictamente correlacionada con la evolución de la tecnología que puede ser explotada para aumentar la calidad de aprendizaje. Los principales argumentos abordados en este documento son massive open on-line courses (MOOC), flipped classrooms y la evolución de los objetos de aprendizaje basados en la web y en la tecnología de internet. En cuanto a los MOOC, realizar un análisis crítico de la situación de este tipo de aprendizaje es necesario para entender su posible evolución y/o su sustitución. Un gran número de estudios de caso demostraron la validez del flipped classroom, y la posibilidad de adoptar este enfoque en el aprendizaje electrónico es sin duda interesante. La última parte del artículo se dedica a las futuras tecnologías, tales como el aprendizaje móvil, los laboratorios virtuales en 3D y el internet de las cosas. Como se ha expuesto, estas últimas innovaciones pueden impulsar la evolución de la educación a distancia, que ofrece soluciones reales centradas en el estudiante.
- Published
- 2017
- Full Text
- View/download PDF
28. Parkinsonian Patients with Deficits in the Dysexecutive Spectrum are Impaired on Theory of Mind Tasks
- Author
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Alberto Costa, Antonella Peppe, Matteo Martini, Katia Coletta, Massimiliano Oliveri, Carlo Caltagirone, and Giovanni A. Carlesimo
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2013
- Full Text
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29. IMMERSE: IMMersive Environment for Representing Self-Avatar Easily.
- Author
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Eros Viola, Matteo Martini, Fabio Solari, and Manuela Chessa
- Published
- 2024
- Full Text
- View/download PDF
30. Is that me or my twin? Lack of self-face recognition advantage in identical twins.
- Author
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Matteo Martini, Ilaria Bufalari, Maria Antonietta Stazi, and Salvatore Maria Aglioti
- Subjects
Medicine ,Science - Abstract
Despite the increasing interest in twin studies and the stunning amount of research on face recognition, the ability of adult identical twins to discriminate their own faces from those of their co-twins has been scarcely investigated. One's own face is the most distinctive feature of the bodily self, and people typically show a clear advantage in recognizing their own face even more than other very familiar identities. Given the very high level of resemblance of their faces, monozygotic twins represent a unique model for exploring self-face processing. Herein we examined the ability of monozygotic twins to distinguish their own face from the face of their co-twin and of a highly familiar individual. Results show that twins equally recognize their own face and their twin's face. This lack of self-face advantage was negatively predicted by how much they felt physically similar to their co-twin and by their anxious or avoidant attachment style. We speculate that in monozygotic twins, the visual representation of the self-face overlaps with that of the co-twin. Thus, to distinguish the self from the co-twin, monozygotic twins have to rely much more than control participants on the multisensory integration processes upon which the sense of bodily self is based. Moreover, in keeping with the notion that attachment style influences perception of self and significant others, we propose that the observed self/co-twin confusion may depend upon insecure attachment.
- Published
- 2015
- Full Text
- View/download PDF
31. Effect of size and heterogeneity of samples on biomarker discovery: synthetic and real data assessment.
- Author
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Barbara Di Camillo, Tiziana Sanavia, Matteo Martini, Giuseppe Jurman, Francesco Sambo, Annalisa Barla, Margherita Squillario, Cesare Furlanello, Gianna Toffolo, and Claudio Cobelli
- Subjects
Medicine ,Science - Abstract
MotivationThe identification of robust lists of molecular biomarkers related to a disease is a fundamental step for early diagnosis and treatment. However, methodologies for the discovery of biomarkers using microarray data often provide results with limited overlap. These differences are imputable to 1) dataset size (few subjects with respect to the number of features); 2) heterogeneity of the disease; 3) heterogeneity of experimental protocols and computational pipelines employed in the analysis. In this paper, we focus on the first two issues and assess, both on simulated (through an in silico regulation network model) and real clinical datasets, the consistency of candidate biomarkers provided by a number of different methods.MethodsWe extensively simulated the effect of heterogeneity characteristic of complex diseases on different sets of microarray data. Heterogeneity was reproduced by simulating both intrinsic variability of the population and the alteration of regulatory mechanisms. Population variability was simulated by modeling evolution of a pool of subjects; then, a subset of them underwent alterations in regulatory mechanisms so as to mimic the disease state.ResultsThe simulated data allowed us to outline advantages and drawbacks of different methods across multiple studies and varying number of samples and to evaluate precision of feature selection on a benchmark with known biomarkers. Although comparable classification accuracy was reached by different methods, the use of external cross-validation loops is helpful in finding features with a higher degree of precision and stability. Application to real data confirmed these results.
- Published
- 2012
- Full Text
- View/download PDF
32. Obstacle Avoidance and Interaction in Extended Reality: An Approach Based on 3D Object Detection.
- Author
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Matteo Martini, Fabio Solari, and Manuela Chessa
- Published
- 2023
- Full Text
- View/download PDF
33. A narrative review on asthma and pest sensitization (cockroach, mouse and rat allergens): a social issue besides the medical problem
- Author
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Gennaro Liccardi, Matteo Martini, Maria Beatrice Bilò, Manlio Milanese, Luigino Calzetta, Rossella Laitano, and Paola Rogliani
- Subjects
Pulmonary and Respiratory Medicine ,Pediatrics, Perinatology and Child Health ,Immunology and Allergy - Published
- 2023
34. Health‐related quality of life in food and venom induced anaphylaxis and role of influencing factors
- Author
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Veronika Höfer, Matteo Martini, Sabine Dölle‐Bierke, Margitta Worm, and Maria Beatrice Bilò
- Subjects
Immunology ,Immunology and Allergy - Abstract
The impact on health-related quality of life (HRQL) plays a key role for patients suffering from allergies and anaphylaxis. In this narrative review we review the HRQL in allergic patients suffering from food and venom allergy, both being the most frequent elicitors of severe allergic, potential life-threatening reactions and provide an overview on the current knowledge and identified gaps. The data show that for food and venom allergy standardized assessment tools to measure HRQL are available and have been successfully applied. Our analysis shows that multiple factors can modulate HRQL in these patient groups. These include sociodemographic data like patients' age and sex, fear of accidental reactions but also external factors like the social environment and the appreciation of the seriousness of the condition by others. External factors may have a significant impact on HRQL and should be considered in patient-related outcome assessments to avoid biased measurements possibly affecting the results. The assessment of the quality of life in the context of specific immunotherapy should consider lifestyle factors and ideally, the individual change in HRQL should be measured. Although there are many data indicating a negative impact on HRQL in food allergic children and their caregivers, limited data are existing from adults with food allergy and venom allergic patients from all age groups. Also, the use of standardized questionnaires should be extended to allow for a better comparability of results between studies. Therefore, translation to additional languages is necessary. Taken together, the eliciting allergen, the severity of the allergic disease but moreover multiple external factors impact the outcome in HRQL and should be considered in HRQL assessment.
- Published
- 2022
35. Laser-Induced Heating in GdVO4: Yb3+/Er3+ Nanocrystals for Thermometry
- Author
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Yujiao Zhou, Gilles Ledoux, David Philippon, Sylvie Descartes, Matteo Martini, Shaozhou He, Cédric Desroches, Didier Fournier, Catherine Journet, and Laurence Bois
- Subjects
General Materials Science - Published
- 2022
36. CO2 Reduction by Nanosecond-Plasma Discharges: Revealing the Dissociation’s Time Scale and the Importance of Pulse Sequence
- Author
-
Cesare Montesano, Toine P.W. Salden, Luca Matteo Martini, Giorgio Dilecce, and Paolo Tosi
- Subjects
Plasma ,Energy ,General Energy ,Electrical energy ,SDG 7 - Affordable and Clean Energy ,Physical and Theoretical Chemistry ,Energy conversion ,SDG 7 – Betaalbare en schone energie ,Dissociation ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
Power-to-chemical technologies with CO2 as feedstock recycle CO2 and store energy into value-added compounds. Plasma discharges fed by renewable electricity are a promising approach to CO2 conversion. However, controlling the mechanisms of plasma dissociation is crucial to improving the efficiency of the technology. We have investigated pulsed nanosecond discharges, showing that while most of the energy is deposited in the breakdown phase, CO2 dissociation only occurs after an order of microsecond delay, leaving the system in a quasi-metastable condition in the intervening time. These findings indicate the presence of delayed dissociation mechanisms mediated by CO2 excited states rather than direct electron impact. This “metastable” condition, favorable for an efficient CO2 dissociation, can be prolonged by depositing more energy in the form of additional pulses and critically depends on a sufficiently short interpulse time.
- Published
- 2023
37. Development of a probability approach to determine water and colloidal pollutant flow behavior in urban heterogeneous soils
- Author
-
Gersende Fernandes, Simone Di Prima, Gislain Lipeme Kouyi, Rafael Angulo-Jaramillo, Matteo Martini, and Laurent Lassabatere
- Abstract
Nature-based systems are being employed to allow stormwater to infiltrate directly in the soil, which is supposed to capture pollutants. To better track the evolution of such systems performances, in particular the infiltration and filtration performances, and to be able to optimize their management, these systems need to be better known. Currently, there is a lack of knowledge and methods regarding the characterization of the macropores and matrix contributions in infiltration and filtration of urban soils, whereas the quality of groundwater and the capacities of these systems are at stake. To tackle these limits, a large infiltrometer of 50 cm in diameter with two water-supply reservoirs of approximately 40 L each, was developed to characterize both hydrodynamic and nanotracers transfer parameters. Cumulative water infiltration was carried out at a constant hydraulic pressure head of 10 cm. Superparamagnetic iron oxide nanoparticles (SPIONs), which mimic both colloidal pollutants and bacteria flow behaviors in soils, were designed to be detectable by ground-penetrating radar (GPR). Fifty volumes of SPIONs solution (i.e., 50 x 5 mL at 3.35g/L) were injected into the ring and the GPR was passed along different survey lines around the ring several times during the infiltration experiment. GPR data was treated with ReflexW (Sandmeier Scientific Software, Karlsruhe, Germany) and Rockware (RockWare, Inc, 2015) to define a 3D block diagram of the infiltration bulb. The probability of presence of the nanoparticles was obtained from comparing the radargrams, before and after nanoparticle injection, by using two methods (Allroggen and Tronicke, 2015; Di Prima et al., 2020) on a R software (https://www.R-project.org/).The large infiltrometer device, compared with a smaller one (Di Prima et al., 2015), is proved effective for estimating water and transfer parameters. The dispersion of SPIONs gave an idea of the relative importance of the transfer through the soil macropores as compared to the soil matrix. The probability of SPIONs presence gave information on the filtration function of soils. The whole device application will be illustrated and discussed with regard to its use for the assessment of the infiltration and filtration functions of bio-infiltration systems. Allroggen, N., Tronicke, J., 2015. Attribute-based analysis of time-lapse ground-penetrating radar data. Geophysics 81, H1–H8. https://doi.org/10.1190/geo2015-0171.1Di Prima, S., Lassabatere, L., Bagarello, V., Iovino, M., Angulo-Jaramillo, R., 2015. Testing a new automated single ring infiltrometer for Beerkan infiltration experiments. Geoderma 262, 20–34. https://doi.org/10.1016/j.geoderma.2015.08.006Di Prima, S., Winiarski, T., Angulo-Jaramillo, R., Stewart, R.D., Castellini, M., Abou Najm, M.R., Ventrella, D., Pirastru, M., Giadrossich, F., Capello, G., Biddoccu, M., Lassabatere, L., 2020. Detecting infiltrated water and preferential flow pathways through time-lapse ground-penetrating radar surveys. Sci. Total Environ. 726, 138511. https://doi.org/10.1016/j.scitotenv.2020.1385
- Published
- 2023
38. Exceeding Equilibrium CO2 Conversion by Plasma-Assisted Chemical Looping
- Author
-
Evangelos Delikonstantis, Marco Scapinello, Varun Singh, Hilde Poelman, Cesare Montesano, Luca Matteo Martini, Paolo Tosi, Guy B. Marin, Kevin M. Van Geem, Vladimir V. Galvita, and Georgios D. Stefanidis
- Subjects
Fuel Technology ,Renewable Energy, Sustainability and the Environment ,Chemistry (miscellaneous) ,Materials Chemistry ,Energy Engineering and Power Technology - Published
- 2022
39. RESULTS AND IMPACT ASSESSMENT OF TWO YEARS OF THE LEAF PROJECT: THE EUROPEAN RESEARCHERS NIGHT FOCUSED ON GREEN DEAL TOPICS
- Author
-
Giorgia Burzachechi, Alessandra Della Ceca, Graziano Ciocca, Eleonora Diociaiuti, Raffaella Donghia, Valeria Guglielmotti, Matteo Martini, and Serena Pierangeli
- Published
- 2023
40. Health-Related Quality of Life and Mental Health in Drug Hypersensitivity Reactions and Drug-Induced Anaphylaxis: A Systematic Review and Meta-Analysis
- Author
-
Matteo Martini, Mariateresa Di Taranto, Veronika Höfer, Margitta Worm, and Maria Beatrice Bilò
- Subjects
Immunology and Allergy - Published
- 2023
41. Fragmentation of interstellar methanol by collisions with He˙+: an experimental and computational study
- Author
-
Vincent Richardson, Emília Valença Ferreira de Aragão, Xiao He, Fernando Pirani, Luca Mancini, Noelia Faginas-Lago, Marzio Rosi, Luca Matteo Martini, and Daniela Ascenzi
- Subjects
General Physics and Astronomy ,Physical and Theoretical Chemistry - Abstract
A combined experimental and theoretical study demonstrates the presence of stereodynamical effects in the charge exchange reactivity of He˙+ with CH3OH, a key process in the astrochemistry of methanol.
- Published
- 2022
42. Increased General, Eating, and Body-Related Psychopathology in Inpatients in a Specialized Eating Disorders Unit after the Beginning of the COVID-19 Pandemic: A Retrospective Comparison with the Pre-Pandemic Period
- Author
-
Delsedime Nadia, Matteo Martini, Giovanni Abbate-Daga, Matteo Panero, and PAOLA LONGO
- Subjects
lockdown ,anorexia nervosa ,hospitalization ,COVID-19 pandemic ,eating disorders ,body-related symptoms ,mental health ,General Medicine - Abstract
The study of the effects of the COVID-19 pandemic on individuals who attended mental health services is needed to identify the specific vulnerabilities associated to this challenging period. Despite several analyses reporting the worsening of eating disorders symptomatology after the beginning of the pandemic, characterizations of adult inpatients with eating disorders are still lacking. We conducted a retrospective analysis to assess whether adult individuals who underwent hospitalization in a specialized eating disorders unit in the two years after the beginning of the COVID-19 pandemic differed in clinical presentation, psychopathological measures, and treatment outcomes from inpatients hospitalized in the two years before. In the comparison between the two groups, the individuals who began treatment after the start of the pandemic presented with more physical hyperactivity and more severe psychopathological scores in most of the areas investigated, with differences in eating symptoms still evident at discharge. Notably, body-related symptoms (i.e., body shape concerns, body checking, body avoidance) were associated with the pandemic, and also for inpatients with extreme anorexia nervosa. This retrospective analysis does not allow us to separate the impact of COVID-19 from other potentially relevant co-occurring factors; however, these findings help in understanding how the pandemic could have affected individuals that needed specialized intensive treatment.
- Published
- 2023
- Full Text
- View/download PDF
43. Anorexia Nervosa in the Acute Hospitalization Setting
- Author
-
Matteo Martini, Marta Lepora, Paola Longo, Laura Amodeo, Enrica Marzola, and Giovanni Abbate-Daga
- Published
- 2023
44. Anorexia Nervosa and Somatoform Dissociation: A Neglected Body-Centered Perspective
- Author
-
Paola Longo, Enrica Marzola, Matteo Martini, Laura Amodeo, and Giovanni Abbate-Daga
- Subjects
Psychiatry and Mental health ,Clinical Psychology ,childhood trauma ,body image ,depression ,Eating disorders ,somatoform dissociation ,anxiety ,psychoform dissociation - Abstract
Dissociation in anorexia nervosa (AN) is common (literature reported 29% of dissociative disorders in eating disorders) and higher in patients with binge-purging AN (BP-AN) than in those with restricter AN (R-AN). However, the distinction between somatoform (SomD) and psychoform dissociation (PsyD) is understudied. We aimed to assess the differences in PsyD and SomD, eating-related, general, and body-related psychopathology, and childhood trauma between subtypes of AN. Then, we attempted to describe a subgroup of patients with AN with marked SomD comparing them to patients without SomD, also controlling the results for PsyD and AN subtypes. Inpatients with AN (n = 111; 109 women and 2 men) completed self-reported questionnaires evaluating dissociation, eating-related, body-related, and general psychopathology, and childhood abuses. Patients with BP-AN reported higher SomD and PsyD and a more severe clinical picture than those with R-AN. The SomD-group (n = 41) showed higher eating concerns, trait-anxiety, body-related variables, and sexual/physical abuse compared to the no-SomD group (n = 70), independently of AN subtype and PsyD symptoms. Results described particular features of patients with AN and SomD. Data, clinically, suggest a careful assessment, for both SomD and PsyD, especially when a history of bodily-impacting trauma is present, potentially fostering dissociation-informed interventions.
- Published
- 2023
45. Pest sensitization to cockroach, mouse, and rat: An Italian multicenter study
- Author
-
Gennaro Liccardi, Maria Beatrice Bilò, Luigino Calzetta, Manlio Milanese, Matteo Martini, Megon Bresciani, Marcello Cilia, Francesco Cucinelli, Romina D'Angelo, Annamaria Feliziani, Francesca Larese Filon, Rocco Longo, Laura Losappio, Giusy Manzotti, Paola Minale, Stella Modica, Francesco Murzilli, Antonino Musarra, Giuseppe Pingitore, Battista Roberto Polillo, Francesca Puggioni, Oliviero Quercia, Carla Rapone, Paola Rogliani, Liccardi, Gennaro, Bilò, Maria Beatrice, Calzetta, Luigino, Milanese, Manlio, Martini, Matteo, Bresciani, Megon, Cilia, Marcello, Cucinelli, Francesco, D'Angelo, Romina, Feliziani, Annamaria, Larese Filon, Francesca, Longo, Rocco, Losappio, Laura, Manzotti, Giusy, Minale, Paola, Modica, Stella, Murzilli, Francesco, Musarra, Antonino, Pingitore, Giuseppe, Polillo, Battista Roberto, Puggioni, Francesca, Quercia, Oliviero, Rapone, Carla, and Rogliani, Paola
- Subjects
pet ,Immunology ,prick test ,Immunology and Allergy ,epidemiology ,sensitization - Abstract
N/A
- Published
- 2023
46. Association of emotion recognition ability and interpersonal emotional competence in anorexia nervosa: A study with a multimodal dynamic task
- Author
-
Matteo Martini, Enrica Marzola, Maria Musso, Annalisa Brustolin, and Giovanni Abbate‐Daga
- Subjects
Psychiatry and Mental health ,emotion regulation ,emotion recognition ,training of emotional competence ,anorexia nervosa ,eating disorders ,individual differences ,social cognition ,theory of mind - Abstract
Interpersonal difficulties are evidenced in Anorexia Nervosa (AN) and are thought to contribute to disease onset and maintenance, however, research in the framework of emotional competence is currently limited. Previous studies have often only used static images for emotion recognition tasks, and evidence is lacking on the relationships between performance-based emotional abilities and self-reported intra- and interpersonal emotional traits. This study aimed to test multimodal dynamic emotion recognition ability in AN and analyze its correlation with the psychometric scores of self- and other-related emotional competence.A total of 268 participants (128 individuals with AN and 140 healthy controls) completed the Geneva Emotion Recognition Test, the Profile of Emotional Competence, the Reading the Mind in the Eyes Test, and measures of general and eating psychopathology. Scores were compared between the two groups. Linear mixed effects models were utilized to examine the relationship between emotion recognition ability and self-reported measures and clinical variables.Individuals with AN showed significantly poorer recognition of emotions of both negative and positive valence and significantly lower scores in all emotional competence dimensions. Beside emotion type and group, linear mixed models evidenced significant effects of interpersonal comprehension on emotion recognition ability.Individuals with AN show impairment in multimodal emotion recognition and report their difficulties accordingly. Notably, among all emotional competence dimensions, interpersonal comprehension emerges as a significant correlate to emotion recognition in others, and could represent a specific area of intervention in the treatment of individuals with AN.In this study, we evidence that the ability to recognize the emotions displayed by others is related to the level of interpersonal emotional competence reported by individuals with anorexia nervosa. This result helps in understanding the social impairments in people with anorexia nervosa and could contribute to advancements in the application of the training of emotional competence in the treatment of this disorder.
- Published
- 2023
47. Platelet‐activating factor acetylhydrolase: A biomarker in Hymenoptera venom allergy?
- Author
-
Alice Di Paolo, Sonila Alia, Arianna Vignini, Gianluca Moroncini, Maria Giovanna Danieli, Alice Corsi, Maria Beatrice Bilò, and Matteo Martini
- Subjects
Immunology ,Tryptase ,Proinflammatory cytokine ,chemistry.chemical_compound ,Hypersensitivity ,medicine ,Animals ,Humans ,Immunology and Allergy ,Receptor ,Anaphylaxis ,Arthropod Venoms ,biology ,Degranulation ,Insect Bites and Stings ,medicine.disease ,Hymenoptera ,Hypersensitivity reaction ,chemistry ,Desensitization, Immunologic ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Prostaglandin D2 ,Biomarkers ,Histamine - Abstract
Anaphylaxis is a rapid, potentially fatal, immediate hypersensitivity reaction. Preformed and newly formed biochemical mediators, including histamine, tryptase, carboxypeptidase A, prostaglandin D2, leukotrienes, and platelet-activating factor (PAF) are released systematically during the degranulation of mast cells and basophils. PAF is a proinflammatory phospholipid, synthesized and secreted by mast cells, monocytes and fixed tissue macrophages whose binding to its receptor on target cell-platelet, monocytes, macrophages, and neutrophils results in many of the manifestation of acute allergic reaction and anaphylaxis.
- Published
- 2021
48. Diagnostic Concordance between Research and Clinical-Based Assessments of Psychiatric Comorbidity in Anorexia Nervosa
- Author
-
Paola Longo, Federica Toppino, Matteo Martini, Matteo Panero, Carlotta De Bacco, Enrica Marzola, and Giovanni Abbate-Daga
- Subjects
anorexia nervosa ,psychiatric comorbidity ,inter-rater reliability ,SCID-5 ,diagnostic assessment ,General Medicine - Abstract
The literature has reported poor concordance in the assessment of psychiatric conditions, and inhomogeneity in the prevalence of psychiatric comorbidities in Anorexia Nervosa (AN). We aimed to investigate concordance level between clinicians’ and researchers’ diagnoses of psychiatric comorbidity in AN and differences in eating and general psychopathology between patients with and without psychiatric comorbidity assessed by clinicians versus researchers. A clinical psychiatrist interviewed 122 patients with AN; then a researcher administered the Structured and Clinical Interview for DSM-5 (SCID-5). Participants completed the Eating Disorder Examination Questionnaire (EDE-Q), the State-Trait Anxiety Inventory (STAI), and the Beck Depression Inventory (BDI). The agreement between clinicians and researchers was poor for all diagnoses but obsessive-compulsive disorder and substance use disorder. Patients with comorbid disorders diagnosed by researchers reported more severe eating and general psychopathology than those without SCID-comorbidity. The differences between patients with and without comorbidities assessed by a clinician were smaller. Two approaches to psychiatry comorbidity assessment emerged: SCID-5 diagnoses yield a precise and rigorous assessment, while clinicians tend to consider some symptoms as secondary to the eating disorder rather than as part of another psychiatric condition, seeing the clinical picture as a whole. Overall, the study highlights the importance of carefully assessing comorbidity in AN.
- Published
- 2022
49. Feeling imperfect and imperfectly feeling: A network analysis on perfectionism, interoceptive sensibility, and eating symptomatology in anorexia nervosa
- Author
-
Matteo Martini, Giovanni Abbate-Daga, Annalisa Brustolin, and Enrica Marzola
- Subjects
Anorexia Nervosa ,media_common.quotation_subject ,ineffectiveness ,interoceptive awareness ,eating disorders ,medicine.disease_cause ,Feeding and Eating Disorders ,drive for thinness ,eating psychopathology ,Thinness ,medicine ,Humans ,Sensibility ,Drive for thinness ,media_common ,Drive ,Psychopathology ,Perfectionism (psychology) ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,Eating disorders ,Feeling ,Anorexia nervosa (differential diagnoses) ,Perfectionism ,Psychology ,Network analysis ,Clinical psychology - Abstract
Objective In recent years, the network analysis (NA) methodology has been applied to identify the central features of the psychopathology of anorexia nervosa (AN) and specific connections to previously recognized vulnerabilities. However, an NA investigating both multidimensional perfectionism and interoceptive sensibility in connection to eating symptomatology is currently missing. Method A total of 260 individuals (139 patients with AN, 121 healthy control individuals) completed the Frost Multidimensional Perfectionism Scale, the Multidimensional Assessment of Interoceptive Awareness and the Eating Disorders Inventory-2. Using state-of-the-art techniques, we estimated a main network with data from all participants and then compared the two separated networks. We checked the variables for empirical overlap through goldbricker, combined as suggested and implemented the empirical measure of the bridge nodes. Results Ineffectiveness and need for control over self and body (resulting from combining Asceticism and Drive for Thinness) were the most central nodes, whereas perfectionistic evaluative concerns (resulting from combining Doubts about Actions and Concern over Mistakes) and mistrust in body sensations were the bridge nodes. No significant differences between the patient and control networks emerged. Conclusions Perfectionistic evaluative concerns and mistrust in body sensations could be key components in the relationships among perfectionism, interoceptive sensibility and eating symptomatology.
- Published
- 2021
50. Sense of self, depression and adaption to grief, in emerging adults who suffered parental loss
- Author
-
Matteo Martini and Shannen Jones
- Subjects
media_common.quotation_subject ,05 social sciences ,Psychology of self ,Psychological intervention ,050109 social psychology ,Professional support ,humanities ,050105 experimental psychology ,Developmental psychology ,0501 psychology and cognitive sciences ,Grief ,Psychological resilience ,Young adult ,Psychology ,General Psychology ,Depression (differential diagnoses) ,media_common - Abstract
The death of a parent is a traumatic event usually accompanied by profound grief and psychological challenges. This study explored some of the factors which may predict sense of self, depression and adaption to grief in 328 parentally bereaved emerging adults. Our findings revealed a presence of pathological grief among young adults. The results also highlighted a strong negative relationship between sense of self and depression. Furthermore, depression was accounted for by sense of self, adaption to grief and time since loss of the parent/s. Interventions for parentally bereaved emerging adults should aim at strengthening their sense of self, for example through boosting resilience, social and professional support, meaningful relationships and ameliorative lifestyle changes.
- Published
- 2021
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