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One of the methods to control the formation of hydrates in oil and gas pipelines is the injection of kinetic hydrate inhibitors (KHIs). The accepted understanding is that KHIs slow down or interfere with hydrate nucleation, forcing an extended “induction time” (time to emergence of viable hydrate crystals) at a given subcooling. As a result, KHIs are commonly evaluated by measuring induction times in the laboratory. However, this experimental approach has some limitations, notably in that data can be stochastic due to the nucleation element, raising questions over reliability/transferability, with multiple repeats often required to establish clear trends. As KHIs also exhibit powerful growth inhibition properties, a new crystal growth inhibition (CGI) method for the evaluation of KHIs has been previously developed with the aim of providing a means to more rapidly evaluate KHIs in a robust manner. This method shows that KHIs induce a number of well-defined hydrate CGI regions with different growth rates as...

BackgroundComparing rates of sudden unexpected death in infancy (SUDI) in different countries and over time is difficult, as these deaths are certified differently in different countries, and, even within the same jurisdiction, changes in this death certification process have occurred over time.AimsTo identify if International Classification of Diseases-10 (ICD-10) codes are being applied differently in different countries, and to develop a more robust tool for international comparison of these types of deaths.MethodsUsage of six ICD-10 codes, which code for the majority of SUDI, was compared for the years 2002–2010 in eight high-income countries.ResultsThere was a great variability in how each country codes SUDI. For example, the proportion of SUDI coded as sudden infant death syndrome (R95) ranged from 32.6% in Japan to 72.5% in Germany. The proportion of deaths coded as accidental suffocation and strangulation in bed (W75) ranged from 1.1% in Germany to 31.7% in New Zealand. Japan was the only country to consistently use the R96 code, with 44.8% of SUDI attributed to that code. The lowest, overall, SUDI rate was seen in the Netherlands (0.19/1000 live births (LB)), and the highest in New Zealand (1.00/1000 LB). SUDI accounted for one-third to half of postneonatal mortality in 2002–2010 for all of the countries except for the Netherlands.ConclusionsThe proposed set of ICD-10 codes encompasses the codes used in different countries for most SUDI cases. Use of these codes will allow for better international comparisons and tracking of trends over time.