Search

Shunsuke Nakakura,1 Minamai Yamamoto,1 Etsuko Terao,1 Nozomi Nagatomi,1 Naoko Matsuo,1 Yausko Fujisawa,1 Yuki Fujio,1 Hitoshi Tabuchi,1 Yoshiaki Kiuchi2 1Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan; 2Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan Purpose: We investigated the incidence of prostaglandin-associated periorbitopathy (PAP) in subjects with glaucoma treated with latanoprost ophthalmic solution.Subjects and methods: One eye and the forehead in 22 subjects were evaluated. All patients had used latanoprost for more than 1 year (range, 12 to 45 months; mean, 26.0 months) and were prostaglandin F2α analogue treatment-naïve. Digital photographs of the subjects obtained before latanoprost therapy and at the last examination were compared retrospectively. Four signs of PAP (deepening of the upper eyelid sulcus (DUES), upper eyelid ptosis, flattening of the lower eyelid bags, and inferior scleral show) and supplemental side effects around the eyelids (eyelash growth, poliosis, and eyelid pigmentation) were judged to be negative or positive by three independent observers. If the observers unanimously rated a sign as positive, the result was defined as positive.Results: Twelve subjects (54.5%) had no apparent signs. Three subjects were judged to have DUES (13.6%), and two subjects each were judged to have flattening of the lower eyelid bags and eyelid pigmentation (9.0%). The other signs were judged as positive in only one subject each, respectively (4.5%). A univariate logistic regression analysis showed no significant associations between any of the signs and age, sex, or the duration of therapy.Conclusion: Latanoprost induced DUES, upper eyelid ptosis, flattening of the lower eyelid bags, inferior scleral show, and supplemental side effects around the eyelids; however, the rates of such occurrence might be relatively low. Keywords: glaucoma, prostaglandin F2α, deepening of the upper eyelid sulcus

A research was conducted to investigate the isolation of bacterial strains have inhibitory effects against Pasteurella piscicida isolated from marine fish intestines and to study some of the properties of the antibacterial substance. A double-layer method was utilized to examine the antibacterial spectrum of Vibrio sp. strain NM 10 against 363 intestinal bacteria. Moreover, the culture supernatant was fractionated with a Molcut L ultrafiltration kit to estimate the molecular mass of the antibacterial substance.

Carbon adsorption to the Si(100) surface in the atmosphere with large or with small concentrations of organic carbons is studied by thermal desorption spectroscopy or x-ray photoelectron spectroscopy. The number of carbon atoms on a Si(100) wafer stored in the pure water, in which the total organic carbon is 285 ppb, increases until a certain time with increasing time stored in pure water, then remains constant. In contrast, that stored in the air in the clean bench, where the concentration of the organic carbon is thought to be low, decreases and the increasing rate of the carbon atoms adsorbed on the Si(100) surface is very small.