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1. Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters

Author

Saigo C, Nomura Y, Yamamoto Y, Sagata M, Matsunaga R, Jono H, Nishi K, and Saito H

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Chika Saigo,1 Yui Nomura,1 Yuko Yamamoto,1 Masataka Sagata,1 Rika Matsunaga,1 Hirofumi Jono,1,2 Kazuhiko Nishi,3 Hideyuki Saito1,2 1Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 2Department of Pharmacy, Kumamoto University Hospital, 3Department of Hemo-Dialysis, Kumamoto University Hospital, Kumamoto, Japan Abstract: Indoxyl sulfate (IS), a putative low-molecular weight uremic toxin, is excreted in the urine under normal kidney function, but is retained in the circulation and tissues during renal dysfunction in acute kidney injury and chronic kidney disease. IS, which is one of the most potent inducers of oxidative stress in the kidney and cardiovascular system, is enzymatically produced in the liver from indole by cytochrome P450-mediated hydroxylation to indoxyl, followed by sulfotransferase-mediated sulfate conjugation. We used rat liver S9 fraction to identify inhibitors of IS production. After testing several compounds, including phytochemical polyphenols, we identified meclofenamate as a potent inhibitor of IS production with an apparent IC50 value of 1.34 µM. Ischemia/reperfusion (I/R) of rat kidney caused a marked elevation in the serum IS concentration 48 hours after surgery. However, intravenous administration of meclofenamate (10 mg/kg) significantly suppressed this increase in the serum level of IS. Moreover, IS concentrations in both kidney and liver were dramatically elevated by renal I/R treatment, but this increase was blocked by meclofenamate. Serum creatinine and blood urea nitrogen were markedly elevated in rats after renal I/R treatment, but these increases were significantly restored by administration of meclofenamate. Renal expression of both basolateral membrane-localized organic anion transporters rOAT1 and rOAT3 was downregulated by I/R treatment. However, expression of rOAT1 and rOAT3 recovered after administration of meclofenamate, which is associated with the inhibition of I/R-evoked elevation of prostaglandin E2. Our results suggest that meclofenamate inhibits hepatic sulfotransferase-mediated production of IS, thereby suppressing serum and renal accumulation of IS. Meclofenamate also prevents the prostaglandin E2-dependent downregulation of rOAT1 and rOAT3 expression. In conclusion, meclofenamate was found to elicit a nephropreventive effect in ischemic acute kidney injury. Keywords: uremic toxins, hepatic sulfotransferase, renal ischemia/reperfusion, renal tubular cell

Published
2014

3. Gapless detection of broadband terahertz pulses using a metal surface in air based on field-induced second-harmonic generation

Author

Tanaka, S., Murotani, Y., Sato, S., Fujimoto, T., Matsuda, T., Kanda, N., Matsunaga, R., and Yoshinobu, J.

Abstract

We investigate second-harmonic generation (SHG) light from a Pt surface in atmosphere under terahertz (THz) pulses. THz pulse-modulated SHG intensity, ΔI2ω⁠, shows a clear time profile of the THz field, which is similar to that of the conventional electro-optic sampling. The result can be explained by interference between THz field-induced second-harmonic light from air molecules in an optical path and a local oscillator from a Pt surface, whereby heterodyne detection of the THz waveform can be achieved. Using numerical calculations of a wave equation, we discuss the contribution of the Gouy phases of all the pulses, including near-infrared, SHG, and THz pulses, and identification of effective nonlinear susceptibility of the Pt surface. Our method, simply using a polished metal surface and air molecules, does not suffer from phonons or phase matching in solid-state optics and does not require any power supply, bias voltage, or fabrication process, but it offers a simple and gapless sampling method for broadband THz pulses. Here, we demonstrate the gapless detection of a broadband THz pulse in the region of 0.2–20 THz using this method.

Published
2023

5. Training During the COVID-19 Lockdown: Knowledge, Beliefs, and Practices of 12,526 Athletes from 142 Countries and Six Continents

Author

Washif, JA, Farooq, A, Krug, I, Pyne, DB, Verhagen, E, Taylor, L, Wong, DP, Mujika, I, Cortis, C, Haddad, M, Ahmadian, O, Al Jufaili, M, Al-Horani, RA, Al-Mohannadi, AS, Aloui, A, Ammar, A, Arifi, F, Aziz, AR, Batuev, M, Beaven, CM, Beneke, R, Bici, A, Bishnoi, P, Bogwasi, L, Bok, D, Boukhris, O, Boullosa, D, Bragazzi, N, Brito, J, Palacios Cartagena, RP, Chaouachi, A, Cheung, SS, Chtourou, H, Cosma, G, Debevec, T, DeLang, MD, Dellal, A, Donmez, G, Driss, T, Duque, JDP, Eirale, C, Elloumi, M, Foster, C, Franchini, E, Fusco, A, Galy, O, Gastin, PB, Gill, N, Girard, O, Gregov, C, Halson, S, Hammouda, O, Hanzlikova, I, Hassanmirzaei, B, Haugen, T, Hebert-Losier, K, Munoz Helu, H, Herrera-Valenzuela, T, Hettinga, FJ, Holtzhausen, L, Hue, O, Dello Iacono, A, Ihalainen, JK, James, C, van Rensburg, DCJ, Joseph, S, Kamoun, K, Khaled, M, Khalladi, K, Kim, KJ, Kok, L-Y, MacMillan, L, Mataruna-Dos-Santos, LJ, Matsunaga, R, Memishi, S, Millet, GP, Moussa-Chamari, I, Musa, DI, Hoang, MTN, Nikolaidis, PT, Owen, A, Padulo, J, Pagaduan, JC, Perera, NP, Perez-Gomez, J, Pillay, L, Popa, A, Pudasaini, A, Rabbani, A, Rahayu, T, Romdhani, M, Salamh, P, Sarkar, A-S, Schillinger, A, Seiler, S, Setyawati, H, Shrestha, N, Suraya, F, Tabben, M, Trabelsi, K, Urhausen, A, Valtonen, M, Weber, J, Whiteley, R, Zrane, A, Zerguini, Y, Zmijewski, P, Sandbakk, O, Ben Saad, H, Chamari, K, Washif, JA, Farooq, A, Krug, I, Pyne, DB, Verhagen, E, Taylor, L, Wong, DP, Mujika, I, Cortis, C, Haddad, M, Ahmadian, O, Al Jufaili, M, Al-Horani, RA, Al-Mohannadi, AS, Aloui, A, Ammar, A, Arifi, F, Aziz, AR, Batuev, M, Beaven, CM, Beneke, R, Bici, A, Bishnoi, P, Bogwasi, L, Bok, D, Boukhris, O, Boullosa, D, Bragazzi, N, Brito, J, Palacios Cartagena, RP, Chaouachi, A, Cheung, SS, Chtourou, H, Cosma, G, Debevec, T, DeLang, MD, Dellal, A, Donmez, G, Driss, T, Duque, JDP, Eirale, C, Elloumi, M, Foster, C, Franchini, E, Fusco, A, Galy, O, Gastin, PB, Gill, N, Girard, O, Gregov, C, Halson, S, Hammouda, O, Hanzlikova, I, Hassanmirzaei, B, Haugen, T, Hebert-Losier, K, Munoz Helu, H, Herrera-Valenzuela, T, Hettinga, FJ, Holtzhausen, L, Hue, O, Dello Iacono, A, Ihalainen, JK, James, C, van Rensburg, DCJ, Joseph, S, Kamoun, K, Khaled, M, Khalladi, K, Kim, KJ, Kok, L-Y, MacMillan, L, Mataruna-Dos-Santos, LJ, Matsunaga, R, Memishi, S, Millet, GP, Moussa-Chamari, I, Musa, DI, Hoang, MTN, Nikolaidis, PT, Owen, A, Padulo, J, Pagaduan, JC, Perera, NP, Perez-Gomez, J, Pillay, L, Popa, A, Pudasaini, A, Rabbani, A, Rahayu, T, Romdhani, M, Salamh, P, Sarkar, A-S, Schillinger, A, Seiler, S, Setyawati, H, Shrestha, N, Suraya, F, Tabben, M, Trabelsi, K, Urhausen, A, Valtonen, M, Weber, J, Whiteley, R, Zrane, A, Zerguini, Y, Zmijewski, P, Sandbakk, O, Ben Saad, H, and Chamari, K

Abstract

OBJECTIVE: Our objective was to explore the training-related knowledge, beliefs, and practices of athletes and the influence of lockdowns in response to the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: Athletes (n = 12,526, comprising 13% world class, 21% international, 36% national, 24% state, and 6% recreational) completed an online survey that was available from 17 May to 5 July 2020 and explored their training behaviors (training knowledge, beliefs/attitudes, and practices), including specific questions on their training intensity, frequency, and session duration before and during lockdown (March-June 2020). RESULTS: Overall, 85% of athletes wanted to "maintain training," and 79% disagreed with the statement that it is "okay to not train during lockdown," with a greater prevalence for both in higher-level athletes. In total, 60% of athletes considered "coaching by correspondence (remote coaching)" to be sufficient (highest amongst world-class athletes). During lockdown, < 40% were able to maintain sport-specific training (e.g., long endurance [39%], interval training [35%], weightlifting [33%], plyometric exercise [30%]) at pre-lockdown levels (higher among world-class, international, and national athletes), with most (83%) training for "general fitness and health maintenance" during lockdown. Athletes trained alone (80%) and focused on bodyweight (65%) and cardiovascular (59%) exercise/training during lockdown. Compared with before lockdown, most athletes reported reduced training frequency (from between five and seven sessions per week to four or fewer), shorter training sessions (from ≥ 60 to < 60 min), and lower sport-specific intensity (~ 38% reduction), irrespective of athlete classification. CONCLUSIONS: COVID-19-related lockdowns saw marked reductions in athletic training specificity, intensity, frequency, and duration, with notable within-sample differences (by athlete clas

Published
2022

6. Training During the COVID-19 Lockdown: Knowledge, Beliefs, and Practices of 12,526 Athletes from 142 Countries and Six Continents (vol 52, pg 933, 2021)

Author

Washif, JA, Farooq, A, Krug, I, Pyne, DB, Verhagen, E, Taylor, L, Wong, DP, Mujika, I, Cortis, C, Haddad, M, Ahmadian, O, Al Jufaili, M, Al-Horani, RA, Al-Mohannadi, AS, Aloui, A, Ammar, A, Arifi, F, Aziz, AR, Batuev, M, Beaven, CM, Beneke, R, Bici, A, Bishnoi, P, Bogwasi, L, Bok, D, Boukhris, O, Boullosa, D, Bragazzi, N, Brito, J, Cartagena, RPP, Chaouachi, A, Cheung, SS, Chtourou, H, Cosma, G, Debevec, T, DeLang, MD, Dellal, A, Donmez, G, Driss, T, Pena Duque, JD, Eirale, C, Elloumi, M, Foster, C, Franchini, E, Fusco, A, Galy, O, Gastin, PB, Gill, N, Girard, O, Gregov, C, Halson, S, Hammouda, O, Hanzlikova, I, Hassanmirzaei, B, Haugen, T, Hebert-Losier, K, Munoz Helu, H, Herrera-Valenzuela, T, Hettinga, FJ, Holtzhausen, L, Hue, O, Dello Iacono, A, Ihalainen, JK, James, C, Janse van Rensburg, DC, Joseph, S, Kamoun, K, Khaled, M, Khalladi, K, Kim, KJ, Kok, L-Y, MacMillan, L, Mataruna-Dos-Santos, LJ, Matsunaga, R, Memishi, S, Millet, GP, Moussa-Chamari, I, Musa, DI, Nguyen, HMT, Nikolaidis, PT, Owen, A, Padulo, J, Pagaduan, JC, Perera, NP, Perez-Gomez, J, Pillay, L, Popa, A, Pudasaini, A, Rabbani, A, Rahayu, T, Romdhani, M, Salamh, P, Sarkar, A-S, Schillinger, A, Seiler, S, Setyawati, H, Shrestha, N, Suraya, F, Tabben, M, Trabelsi, K, Urhausen, A, Valtonen, M, Weber, J, Whiteley, R, Zrane, A, Zerguini, Y, Zmijewski, P, Sandbakk, O, Ben Saad, H, Chamari, K, Washif, JA, Farooq, A, Krug, I, Pyne, DB, Verhagen, E, Taylor, L, Wong, DP, Mujika, I, Cortis, C, Haddad, M, Ahmadian, O, Al Jufaili, M, Al-Horani, RA, Al-Mohannadi, AS, Aloui, A, Ammar, A, Arifi, F, Aziz, AR, Batuev, M, Beaven, CM, Beneke, R, Bici, A, Bishnoi, P, Bogwasi, L, Bok, D, Boukhris, O, Boullosa, D, Bragazzi, N, Brito, J, Cartagena, RPP, Chaouachi, A, Cheung, SS, Chtourou, H, Cosma, G, Debevec, T, DeLang, MD, Dellal, A, Donmez, G, Driss, T, Pena Duque, JD, Eirale, C, Elloumi, M, Foster, C, Franchini, E, Fusco, A, Galy, O, Gastin, PB, Gill, N, Girard, O, Gregov, C, Halson, S, Hammouda, O, Hanzlikova, I, Hassanmirzaei, B, Haugen, T, Hebert-Losier, K, Munoz Helu, H, Herrera-Valenzuela, T, Hettinga, FJ, Holtzhausen, L, Hue, O, Dello Iacono, A, Ihalainen, JK, James, C, Janse van Rensburg, DC, Joseph, S, Kamoun, K, Khaled, M, Khalladi, K, Kim, KJ, Kok, L-Y, MacMillan, L, Mataruna-Dos-Santos, LJ, Matsunaga, R, Memishi, S, Millet, GP, Moussa-Chamari, I, Musa, DI, Nguyen, HMT, Nikolaidis, PT, Owen, A, Padulo, J, Pagaduan, JC, Perera, NP, Perez-Gomez, J, Pillay, L, Popa, A, Pudasaini, A, Rabbani, A, Rahayu, T, Romdhani, M, Salamh, P, Sarkar, A-S, Schillinger, A, Seiler, S, Setyawati, H, Shrestha, N, Suraya, F, Tabben, M, Trabelsi, K, Urhausen, A, Valtonen, M, Weber, J, Whiteley, R, Zrane, A, Zerguini, Y, Zmijewski, P, Sandbakk, O, Ben Saad, H, and Chamari, K

Published
2022

7. COVID-19 Lockdown: A Global Study Investigating the Effect of Athletes' Sport Classification and Sex on Training Practices.

Author

Washif, JA, Sandbakk, Ø, Seiler, S, Haugen, T, Farooq, A, Quarrie, K, Janse van Rensburg, DC, Krug, I, Verhagen, E, Wong, DP, Mujika, I, Musa, DI, Nguyen, HMT, Nikolaidis, PT, Owen, A, Padulo, J, Pagaduan, JC, Perera, NP, Pérez-Gómez, J, Pillay, L, Popa, A, Rabbani, A, Pudasaini, A, Rahayu, T, Romdhani, M, Salamh, P, Sarkar, A-S, Schillinger, A, Setyawati, H, Shrestha, N, Suraya, F, Tabben, M, Urhausen, A, Trabelsi, K, Valtonen, M, Weber, J, Whiteley, R, Zrane, A, Zerguini, Y, Zmijewski, P, Ben Saad, H, Pyne, DB, Taylor, L, Cortis, C, Chamari, K, Haddad, M, Ahmadian, O, Al Jufaili, M, Al-Horani, RA, Al-Mohannadi, AS, Aloui, A, Ammar, A, Arifi, F, Aziz, AR, Batuev, M, Beaven, CM, Beneke, R, Bici, A, Bishnoi, P, Bogwasi, L, Bok, D, Boukhris, O, Boullosa, D, Bragazzi, N, Brito, J, Palacios Cartagena, RP, Chaouachi, A, Cheung, SS, Chtourou, H, Cosma, G, Debevec, T, DeLang, MD, Dellal, A, Dönmez, G, Driss, T, Peña Duque, JD, Eirale, C, Elloumi, M, Foster, C, Franchini, E, Fusco, A, Galy, O, Gastin, PB, Gill, N, Girard, O, Gregov, C, Halson, S, Hammouda, O, Hanzlíková, I, Hassanmirzaei, B, Hébert-Losier, K, Muñoz Helú, H, Herrera-Valenzuela, T, Hettinga, FJ, Holtzhausen, L, Hue, O, Dello Iacono, A, Ihalainen, JK, James, C, Joseph, S, Kamoun, K, Khaled, M, Khalladi, K, Kim, KJ, Kok, L-Y, MacMillan, L, Mataruna-Dos-Santos, LJ, Matsunaga, R, Memishi, S, Millet, GP, Moussa-Chamari, I, Washif, JA, Sandbakk, Ø, Seiler, S, Haugen, T, Farooq, A, Quarrie, K, Janse van Rensburg, DC, Krug, I, Verhagen, E, Wong, DP, Mujika, I, Musa, DI, Nguyen, HMT, Nikolaidis, PT, Owen, A, Padulo, J, Pagaduan, JC, Perera, NP, Pérez-Gómez, J, Pillay, L, Popa, A, Rabbani, A, Pudasaini, A, Rahayu, T, Romdhani, M, Salamh, P, Sarkar, A-S, Schillinger, A, Setyawati, H, Shrestha, N, Suraya, F, Tabben, M, Urhausen, A, Trabelsi, K, Valtonen, M, Weber, J, Whiteley, R, Zrane, A, Zerguini, Y, Zmijewski, P, Ben Saad, H, Pyne, DB, Taylor, L, Cortis, C, Chamari, K, Haddad, M, Ahmadian, O, Al Jufaili, M, Al-Horani, RA, Al-Mohannadi, AS, Aloui, A, Ammar, A, Arifi, F, Aziz, AR, Batuev, M, Beaven, CM, Beneke, R, Bici, A, Bishnoi, P, Bogwasi, L, Bok, D, Boukhris, O, Boullosa, D, Bragazzi, N, Brito, J, Palacios Cartagena, RP, Chaouachi, A, Cheung, SS, Chtourou, H, Cosma, G, Debevec, T, DeLang, MD, Dellal, A, Dönmez, G, Driss, T, Peña Duque, JD, Eirale, C, Elloumi, M, Foster, C, Franchini, E, Fusco, A, Galy, O, Gastin, PB, Gill, N, Girard, O, Gregov, C, Halson, S, Hammouda, O, Hanzlíková, I, Hassanmirzaei, B, Hébert-Losier, K, Muñoz Helú, H, Herrera-Valenzuela, T, Hettinga, FJ, Holtzhausen, L, Hue, O, Dello Iacono, A, Ihalainen, JK, James, C, Joseph, S, Kamoun, K, Khaled, M, Khalladi, K, Kim, KJ, Kok, L-Y, MacMillan, L, Mataruna-Dos-Santos, LJ, Matsunaga, R, Memishi, S, Millet, GP, and Moussa-Chamari, I

Abstract

PURPOSE: To investigate differences in athletes' knowledge, beliefs, and training practices during COVID-19 lockdowns with reference to sport classification and sex. This work extends an initial descriptive evaluation focusing on athlete classification. METHODS: Athletes (12,526; 66% male; 142 countries) completed an online survey (May-July 2020) assessing knowledge, beliefs, and practices toward training. Sports were classified as team sports (45%), endurance (20%), power/technical (10%), combat (9%), aquatic (6%), recreational (4%), racquet (3%), precision (2%), parasports (1%), and others (1%). Further analysis by sex was performed. RESULTS: During lockdown, athletes practiced body-weight-based exercises routinely (67% females and 64% males), ranging from 50% (precision) to 78% (parasports). More sport-specific technical skills were performed in combat, parasports, and precision (∼50%) than other sports (∼35%). Most athletes (range: 50% [parasports] to 75% [endurance]) performed cardiorespiratory training (trivial sex differences). Compared to prelockdown, perceived training intensity was reduced by 29% to 41%, depending on sport (largest decline: ∼38% in team sports, unaffected by sex). Some athletes (range: 7%-49%) maintained their training intensity for strength, endurance, speed, plyometric, change-of-direction, and technical training. Athletes who previously trained ≥5 sessions per week reduced their volume (range: 18%-28%) during lockdown. The proportion of athletes (81%) training ≥60 min/session reduced by 31% to 43% during lockdown. Males and females had comparable moderate levels of training knowledge (56% vs 58%) and beliefs/attitudes (54% vs 56%). CONCLUSIONS: Changes in athletes' training practices were sport-specific, with few or no sex differences. Team-based sports were generally more susceptible to changes than individual sports. Policy makers should provide athletes with specific training arrangements and educational resources to facilitate remot

Published
2022

11. Training During the COVID-19 Lockdown: Knowledge, Beliefs, and Practices of 12,526 Athletes from 142 Countries and Six Continents.

Author

Washif, JA, Farooq, A, Krug, I, Pyne, DB, Verhagen, E, Taylor, L, Wong, DP, Mujika, I, Cortis, C, Haddad, M, Ahmadian, O, Al Jufaili, M, Al-Horani, RA, Al-Mohannadi, AS, Aloui, A, Ammar, A, Arifi, F, Aziz, AR, Batuev, M, Beaven, CM, Beneke, R, Bici, A, Bishnoi, P, Bogwasi, L, Bok, D, Boukhris, O, Boullosa, D, Bragazzi, N, Brito, J, Cartagena, RPP, Chaouachi, A, Cheung, SS, Chtourou, H, Cosma, G, Debevec, T, DeLang, MD, Dellal, A, Dönmez, G, Driss, T, Peña Duque, JD, Eirale, C, Elloumi, M, Foster, C, Franchini, E, Fusco, A, Galy, O, Gastin, PB, Gill, N, Girard, O, Gregov, C, Halson, S, Hammouda, O, Hanzlíková, I, Hassanmirzaei, B, Haugen, T, Hébert-Losier, K, Muñoz Helú, H, Herrera-Valenzuela, T, Hettinga, FJ, Holtzhausen, L, Hue, O, Dello Iacono, A, Ihalainen, JK, James, C, Janse van Rensburg, DC, Joseph, S, Kamoun, K, Khaled, M, Khalladi, K, Kim, KJ, Kok, L-Y, MacMillan, L, Mataruna-Dos-Santos, LJ, Matsunaga, R, Memishi, S, Millet, GP, Moussa-Chamari, I, Musa, DI, Nguyen, HMT, Nikolaidis, PT, Owen, A, Padulo, J, Pagaduan, JC, Perera, NP, Pérez-Gómez, J, Pillay, L, Popa, A, Pudasaini, A, Rabbani, A, Rahayu, T, Romdhani, M, Salamh, P, Sarkar, A-S, Schillinger, A, Seiler, S, Setyawati, H, Shrestha, N, Suraya, F, Tabben, M, Trabelsi, K, Urhausen, A, Valtonen, M, Weber, J, Whiteley, R, Zrane, A, Zerguini, Y, Zmijewski, P, Sandbakk, Ø, Ben Saad, H, Chamari, K, Washif, JA, Farooq, A, Krug, I, Pyne, DB, Verhagen, E, Taylor, L, Wong, DP, Mujika, I, Cortis, C, Haddad, M, Ahmadian, O, Al Jufaili, M, Al-Horani, RA, Al-Mohannadi, AS, Aloui, A, Ammar, A, Arifi, F, Aziz, AR, Batuev, M, Beaven, CM, Beneke, R, Bici, A, Bishnoi, P, Bogwasi, L, Bok, D, Boukhris, O, Boullosa, D, Bragazzi, N, Brito, J, Cartagena, RPP, Chaouachi, A, Cheung, SS, Chtourou, H, Cosma, G, Debevec, T, DeLang, MD, Dellal, A, Dönmez, G, Driss, T, Peña Duque, JD, Eirale, C, Elloumi, M, Foster, C, Franchini, E, Fusco, A, Galy, O, Gastin, PB, Gill, N, Girard, O, Gregov, C, Halson, S, Hammouda, O, Hanzlíková, I, Hassanmirzaei, B, Haugen, T, Hébert-Losier, K, Muñoz Helú, H, Herrera-Valenzuela, T, Hettinga, FJ, Holtzhausen, L, Hue, O, Dello Iacono, A, Ihalainen, JK, James, C, Janse van Rensburg, DC, Joseph, S, Kamoun, K, Khaled, M, Khalladi, K, Kim, KJ, Kok, L-Y, MacMillan, L, Mataruna-Dos-Santos, LJ, Matsunaga, R, Memishi, S, Millet, GP, Moussa-Chamari, I, Musa, DI, Nguyen, HMT, Nikolaidis, PT, Owen, A, Padulo, J, Pagaduan, JC, Perera, NP, Pérez-Gómez, J, Pillay, L, Popa, A, Pudasaini, A, Rabbani, A, Rahayu, T, Romdhani, M, Salamh, P, Sarkar, A-S, Schillinger, A, Seiler, S, Setyawati, H, Shrestha, N, Suraya, F, Tabben, M, Trabelsi, K, Urhausen, A, Valtonen, M, Weber, J, Whiteley, R, Zrane, A, Zerguini, Y, Zmijewski, P, Sandbakk, Ø, Ben Saad, H, and Chamari, K

Abstract

OBJECTIVE: Our objective was to explore the training-related knowledge, beliefs, and practices of athletes and the influence of lockdowns in response to the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: Athletes (n = 12,526, comprising 13% world class, 21% international, 36% national, 24% state, and 6% recreational) completed an online survey that was available from 17 May to 5 July 2020 and explored their training behaviors (training knowledge, beliefs/attitudes, and practices), including specific questions on their training intensity, frequency, and session duration before and during lockdown (March-June 2020). RESULTS: Overall, 85% of athletes wanted to "maintain training," and 79% disagreed with the statement that it is "okay to not train during lockdown," with a greater prevalence for both in higher-level athletes. In total, 60% of athletes considered "coaching by correspondence (remote coaching)" to be sufficient (highest amongst world-class athletes). During lockdown, < 40% were able to maintain sport-specific training (e.g., long endurance [39%], interval training [35%], weightlifting [33%], plyometric exercise [30%]) at pre-lockdown levels (higher among world-class, international, and national athletes), with most (83%) training for "general fitness and health maintenance" during lockdown. Athletes trained alone (80%) and focused on bodyweight (65%) and cardiovascular (59%) exercise/training during lockdown. Compared with before lockdown, most athletes reported reduced training frequency (from between five and seven sessions per week to four or fewer), shorter training sessions (from ≥ 60 to < 60 min), and lower sport-specific intensity (~ 38% reduction), irrespective of athlete classification. CONCLUSIONS: COVID-19-related lockdowns saw marked reductions in athletic training specificity, intensity, frequency, and duration, with notable within-sample differences (by athlete clas

Published
2021

15. 346P Phase I study of the liposomal formulation of eribulin (E7389-LF): Results from the HER2-negative breast cancer expansion

Author

Tamura, K., primary, Takahashi, S., additional, Mukohara, T., additional, Tanioka, M., additional, Yasojima, H., additional, Ono, M., additional, Naito, Y., additional, Shimoi, T., additional, Otani, Y., additional, Kobayashi, K., additional, Kogawa, T., additional, Suzuki, T., additional, Takase, T., additional, Matsunaga, R., additional, and Masuda, N., additional

Published
2020
Full Text
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16. 583P Effect of infusion rate, premedication, and prophylactic peg-filgrastim treatment on the safety of the liposomal formulation of eribulin (E7389-LF): Results from the expansion part of a phase I study

Author

Iwasa, S., primary, Takahashi, S., additional, Hirao, M., additional, Kato, K., additional, Shitara, K., additional, Sato, Y., additional, Hamakawa, T., additional, Horinouchi, H., additional, Tahara, M., additional, Chin, K., additional, Mizutani, M., additional, Suzuki, T., additional, Takase, T., additional, Matsunaga, R., additional, and Mukohara, T., additional

Published
2020
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30. Six-year survival of unoperated ventricular septal rupture following myocardial infarction

Author

Kamishirado, H, Inoue, T, Sakai, Y, Matsunaga, R, and Morooka, S

Subjects
Male, Fatal Outcome, Time Factors, Myocardium, Correspondence, cardiovascular system, Humans, cardiovascular diseases, Coronary Angiography, Aged, Ventricular Septal Rupture, Research Article
Abstract

We present the case of a patient who survived for 6 years without surgical repair of a ventricular septal rupture that followed an acute myocardial infarction. To the best of our knowledge, only 3 other cases have been reported in which the patient survived for more than 5 years.

Published
1999

34. Embryology

Author

Gandhi, G., primary, Allahbadia, G., additional, Kagalwala, S., additional, Allahbadia, A., additional, Ramesh, S., additional, Patel, K., additional, Hinduja, R., additional, Chipkar, V., additional, Madne, M., additional, Ramani, R., additional, Joo, J. K., additional, Jeung, J. E., additional, Go, K. R., additional, Lee, K. S., additional, Goto, H., additional, Hashimoto, S., additional, Amo, A., additional, Yamochi, T., additional, Iwata, H., additional, Morimoto, Y., additional, Koifman, M., additional, Lahav-Baratz, S., additional, Blais, E., additional, Megnazi-Wiener, Z., additional, Ishai, D., additional, Auslender, R., additional, Dirnfeld, M., additional, Zaletova, V., additional, Zakharova, E., additional, Krivokharchenko, I., additional, Zaletov, S., additional, Zhu, L., additional, Li, Y., additional, Zhang, H., additional, Ai, J., additional, Jin, L., additional, Zhang, X., additional, Rajan, N., additional, Kovacs, A., additional, Foley, C., additional, Flanagan, J., additional, O'Callaghan, J., additional, Waterstone, J., additional, Dineen, T., additional, Dahdouh, E. M., additional, St-Michel, P., additional, Granger, L., additional, Carranza-Mamane, B., additional, Faruqi, F., additional, Kattygnarath, T. V., additional, Gomes, F. L. A. F., additional, Christoforidis, N., additional, Ioakimidou, C., additional, Papas, C., additional, Moisidou, M., additional, Chatziparasidou, A., additional, Klaver, M., additional, Tilleman, K., additional, De Sutter, P., additional, Lammers, J., additional, Freour, T., additional, Splingart, C., additional, Barriere, P., additional, Ikeno, T., additional, Nakajyo, Y., additional, Sato, Y., additional, Hirata, K., additional, Kyoya, T., additional, Kyono, K., additional, Campos, F. B., additional, Meseguer, M., additional, Nogales, M., additional, Martinez, E., additional, Ariza, M., additional, Agudo, D., additional, Rodrigo, L., additional, Garcia-Velasco, J. A., additional, Lopes, A. S., additional, Frederickx, V., additional, Vankerkhoven, G., additional, Serneels, A., additional, Roziers, P., additional, Puttermans, P., additional, Campo, R., additional, Gordts, S., additional, Fragouli, E., additional, Alfarawati, S., additional, Spath, K., additional, Wells, D., additional, Liss, J., additional, Lukaszuk, K., additional, Glowacka, J., additional, Bruszczynska, A., additional, Gallego, S. C., additional, Lopez, L. O., additional, Vila, E. O., additional, Garcia, M. G., additional, Canas, C. L., additional, Segovia, A. G., additional, Ponce, A. G., additional, Calonge, R. N., additional, Peregrin, P. C., additional, Ito, K., additional, Nakaoka, Y., additional, Alcoba, D. D., additional, Valerio, E. G., additional, Conzatti, M., additional, Tornquist, J., additional, Kussler, A. P., additional, Pimentel, A. M., additional, Corleta, H. E., additional, Brum, I. S., additional, Boyer, P., additional, Montjean, D., additional, Tourame, P., additional, Gervoise-Boyer, M., additional, Cohen, J., additional, Lefevre, B., additional, Radio, C. I., additional, Wolf, J. P., additional, Ziyyat, A., additional, De Croo, I., additional, Tolpe, A., additional, Degheselle, S., additional, Van de Velde, A., additional, Van den Abbeel, E., additional, Gandhi, G., additional, Kuwayama, M., additional, Khatoon, A., additional, Alsule, S., additional, Inaba, M., additional, Ohgaki, A., additional, Ohtani, A., additional, Matsumoto, H., additional, Mizuno, S., additional, Mori, R., additional, Fukuda, A., additional, Umekawa, Y., additional, Yoshida, A., additional, Tanigiwa, S., additional, Seida, K., additional, Suzuki, H., additional, Tanaka, M., additional, Vahabi, Z., additional, Yazdi, P. E., additional, Dalman, A., additional, Ebrahimi, B., additional, Mostafaei, F., additional, Niknam, M. R., additional, Watanabe, S., additional, Kamihata, M., additional, Tanaka, T., additional, Matsunaga, R., additional, Yamanaka, N., additional, Kani, C., additional, Ishikawa, T., additional, Wada, T., additional, Morita, H., additional, Miyamura, H., additional, Nishio, E., additional, Ito, M., additional, Kuwahata, A., additional, Ochi, M., additional, Horiuchi, T., additional, Dal Canto, M., additional, Guglielmo, M. C., additional, Fadini, R., additional, Renzini, M. M., additional, Albertini, D. F., additional, Novara, P., additional, Lain, M., additional, Brambillasca, F., additional, Turchi, D., additional, Sottocornola, M., additional, Coticchio, G., additional, Kato, M., additional, Fukunaga, N., additional, Nagai, R., additional, Kitasaka, H., additional, Yoshimura, T., additional, Tamura, F., additional, Hasegawa, N., additional, Nakayama, K., additional, Takeuchi, M., additional, Ohno, H., additional, Aoyagi, N., additional, Kojima, E., additional, Itoi, F., additional, Hashiba, Y., additional, Asada, Y., additional, Kikuchi, H., additional, Iwasa, Y., additional, Kamono, T., additional, Suzuki, A., additional, Yamada, K., additional, Kanno, H., additional, Sasaki, K., additional, Murakawa, H., additional, Matsubara, M., additional, Yoshida, H., additional, Valdespin, C., additional, Elhelaly, M., additional, Chen, P., additional, Pangestu, M., additional, Catt, S., additional, Hojnik, N., additional, Kovacic, B., additional, Roglic, P., additional, Taborin, M., additional, Zafosnik, M., additional, Knez, J., additional, Vlaisavljevic, V., additional, Mori, C., additional, Yabuuchi, A., additional, Ezoe, K., additional, Takayama, Y., additional, Aono, F., additional, Kato, K., additional, Radwan, P., additional, Krasinski, R., additional, Chorobik, K., additional, Radwan, M., additional, Stoppa, M., additional, Maggiulli, R., additional, Capalbo, A., additional, Ievoli, E., additional, Dovere, L., additional, Scarica, C., additional, Albricci, L., additional, Romano, S., additional, Sanges, F., additional, Barnocchi, N., additional, Papini, L., additional, Vivarelli, A., additional, Ubaldi, F. M., additional, Rienzi, L., additional, Bono, S., additional, Spizzichino, L., additional, Rubio, C., additional, Fiorentino, F., additional, Ferris, J., additional, Favetta, L. A., additional, MacLusky, N., additional, King, W. A., additional, Madani, T., additional, Jahangiri, N., additional, Aflatoonian, R., additional, Cater, E., additional, Hulme, D., additional, Berrisford, K., additional, Jenner, L., additional, Campbell, A., additional, Fishel, S., additional, Zhang, X. Y., additional, Yilmaz, A., additional, Hananel, H., additional, Ao, A., additional, Vutyavanich, T., additional, Piromlertamorn, W., additional, Saenganan, U., additional, Samchimchom, S., additional, Wirleitner, B., additional, Lejeune, B., additional, Zech, N. H., additional, Vanderzwalmen, P., additional, Albani, E., additional, Parini, V., additional, Smeraldi, A., additional, Menduni, F., additional, Antonacci, R., additional, Marras, A., additional, Levi, S., additional, Morreale, G., additional, Pisano, B., additional, Di Biase, A., additional, Di Rosa, A., additional, Setti, P. E. L., additional, Puard, V., additional, Cadoret, V., additional, Tranchant, T., additional, Gauthier, C., additional, Reiter, E., additional, Guerif, F., additional, Royere, D., additional, Yoon, S. Y., additional, Eum, J. H., additional, Park, E. A., additional, Kim, T. Y., additional, Yoon, T. K., additional, Lee, D. R., additional, Lee, W. S., additional, Cabal, A. C., additional, Vallejo, B., additional, Campos, P., additional, Sanchez, E., additional, Serrano, J., additional, Remohi, J., additional, Nagornyy, V., additional, Mazur, P., additional, Mykytenko, D., additional, Semeniuk, L., additional, Zukin, V., additional, Guilherme, P., additional, Madaschi, C., additional, Bonetti, T. C. S., additional, Fassolas, G., additional, Izzo, C. R., additional, Santos, M. J. D. L., additional, Beltran, D., additional, Garcia-Laez, V., additional, Escriba, M. J., additional, Grau, N., additional, Escrich, L., additional, Albert, C., additional, Zuzuarregui, J. L., additional, Pellicer, A., additional, LU, Y., additional, Nikiforaki, D., additional, Meerschaut, F. V., additional, Neupane, J., additional, De Vos, W. H., additional, Lierman, S., additional, Deroo, T., additional, Heindryckx, B., additional, Li, J., additional, Chen, X. Y., additional, Lin, G., additional, Huang, G. N., additional, Sun, Z. Y., additional, Zhong, Y., additional, Zhang, B., additional, Li, T., additional, Zhang, S. P., additional, Ye, H., additional, Han, S. B., additional, Liu, S. Y., additional, Zhou, J., additional, Lu, G. X., additional, Zhuang, G. L., additional, Muela, L., additional, Roldan, M., additional, Gadea, B., additional, Martinez, M., additional, Perez, I., additional, Munoz, M., additional, Castello, C., additional, Asensio, M., additional, Fernandez, P., additional, Farreras, A., additional, Rovira, S., additional, Capdevila, J. M., additional, Velilla, E., additional, Lopez-Teijon, M., additional, Kovacs, P., additional, Matyas, S. Z., additional, Forgacs, V., additional, Reichart, A., additional, Rarosi, F., additional, Bernard, A., additional, Torok, A., additional, Kaali, S. G., additional, Sajgo, A., additional, Pribenszky, C. S., additional, Sozen, B., additional, Ozturk, S., additional, Yaba-Ucar, A., additional, Demir, N., additional, Gelo, N., additional, Stanic, P., additional, Hlavati, V., additional, ogoric, S., additional, Pavicic-Baldani, D., additional, prem-Goldtajn, M., additional, Radakovic, B., additional, Kasum, M., additional, Strelec, M., additional, Canic, T., additional, imunic, V., additional, Vrcic, H., additional, Ajina, M., additional, Negra, D., additional, Ben-Ali, H., additional, Jallad, S., additional, Zidi, I., additional, Meddeb, S., additional, Bibi, M., additional, Khairi, H., additional, Saad, A., additional, Gamiz, P., additional, Viloria, T., additional, Lima, E. T., additional, Fernandez, M. P., additional, Prieto, J. A. A., additional, Varela, M. O., additional, Kassa, D., additional, Munoz, E. M., additional, Kani, K., additional, Nor-Ashikin, M. N. K., additional, Norhazlin, J. M. Y., additional, Norita, S., additional, Wan-Hafizah, W. J., additional, Mohd-Fazirul, M., additional, Razif, D., additional, Hoh, B. P., additional, Dale, S., additional, Woodhead, G., additional, Andronikou, S., additional, Francis, G., additional, Tailor, S., additional, Vourliotis, M., additional, Almeida, P. A., additional, Krivega, M., additional, Van de Velde, H., additional, Lee, R. K., additional, Hwu, Y. M., additional, Lu, C. H., additional, Li, S. H., additional, Vaiarelli, A., additional, Desgro, M., additional, Baggiani, A., additional, Zannoni, E., additional, Kermavner, L. B., additional, Klun, I. V., additional, Pinter, B., additional, Vrtacnik-Bokal, E., additional, De Paepe, C., additional, Cauffman, G., additional, Verheyen, G., additional, Stoop, D., additional, Liebaers, I., additional, Stecher, A., additional, Zintz, M., additional, Neyer, A., additional, Bach, M., additional, Baramsai, B., additional, Schwerda, D., additional, Wiener-Megnazi, Z., additional, Fridman, M., additional, Blais, I., additional, Akerud, H., additional, Lindgren, K., additional, Karehed, K., additional, Wanggren, K., additional, Hreinsson, J., additional, Freijomil, B., additional, Weiss, A., additional, Neril, R., additional, Geslevich, J., additional, Beck-Fruchter, R., additional, Lavee, M., additional, Golan, J., additional, Ermoshkin, A., additional, Shalev, E., additional, Shi, W., additional, Zhang, S., additional, Zhao, W., additional, Xue, X. I. A., additional, Wang, M. I. N., additional, Bai, H., additional, Shi, J., additional, Smith, H. L., additional, Shaw, L., additional, Kimber, S., additional, Brison, D., additional, Boumela, I., additional, Assou, S., additional, Haouzi, D., additional, Ahmed, O. A., additional, Dechaud, H., additional, Hamamah, S., additional, Dasiman, R., additional, Nor-Shahida, A. R., additional, Salina, O., additional, Gabriele, R. A. F., additional, Ben-Yosef, D., additional, Shwartz, T., additional, Cohen, T., additional, Carmon, A., additional, Raz, N. M., additional, Malcov, M., additional, Frumkin, T., additional, Almog, B., additional, Vagman, I., additional, Kapustiansky, R., additional, Reches, A., additional, Azem, F., additional, Amit, A., additional, Cetinkaya, M., additional, Pirkevi, C., additional, Yelke, H., additional, Kumtepe, Y., additional, Atayurt, Z., additional, Kahraman, S., additional, Risco, R., additional, Hebles, M., additional, Saa, A. M., additional, Vilches-Ferron, M. A., additional, Sanchez-Martin, P., additional, Lucena, E., additional, Lucena, M., additional, Heras, M. D. L., additional, Agirregoikoa, J. A., additional, Barrenetxea, G., additional, De Pablo, J. L., additional, Lehner, A., additional, Pribenszky, C., additional, Murber, A., additional, Rigo, J., additional, Urbancsek, J., additional, Fancsovits, P., additional, Bano, D. G., additional, Sanchez-Leon, A., additional, Marcos, J., additional, Molla, M., additional, Amorocho, B., additional, Nicolas, M., additional, Fernandez, L., additional, Landeras, J., additional, Adeniyi, O. A., additional, Ehbish, S. M., additional, Brison, D. R., additional, Egashira, A., additional, Murakami, M., additional, Nagafuchi, E., additional, Tanaka, K., additional, Tomohara, A., additional, Mine, C., additional, Otsubo, H., additional, Nakashima, A., additional, Otsuka, M., additional, Yoshioka, N., additional, Kuramoto, T., additional, Choi, D., additional, Yang, H., additional, Park, J. H., additional, Jung, J. H., additional, Hwang, H. G., additional, Lee, J. H., additional, Lee, J. E., additional, Kang, A. S., additional, Yoo, J. H., additional, Kwon, H. C., additional, Lee, S. J., additional, Bang, S., additional, Shin, H., additional, Lim, H. J., additional, Min, S. H., additional, Yeon, J. Y., additional, Koo, D. B., additional, Higo, S., additional, Ruvalcaba, L., additional, Kobayashi, M., additional, Takeuchi, T., additional, Miwa, A., additional, Nagai, Y., additional, Momma, Y., additional, Takahashi, K., additional, Chuko, M., additional, Nagai, A., additional, Otsuki, J., additional, Kim, S. G., additional, Kim, Y. Y., additional, Kim, H. J., additional, Park, I. H., additional, Sun, H. G., additional, Lee, K. H., additional, Song, H. J., additional, Costa-Borges, N., additional, Belles, M., additional, Herreros, J., additional, Teruel, J., additional, Ballesteros, A., additional, Calderon, G., additional, Vossaert, L., additional, Qian, C., additional, Lu, Y., additional, Parys, J. B., additional, Deforce, D., additional, Leybaert, L., additional, Surlan, L., additional, Otasevic, V., additional, Velickovic, K., additional, Golic, I., additional, Vucetic, M., additional, Stankovic, V., additional, Stojnic, J., additional, Radunovic, N., additional, Tulic, I., additional, Korac, B., additional, Korac, A., additional, Elias, R., additional, Neri, Q. V., additional, Fields, T., additional, Schlegel, P. N., additional, Rosenwaks, Z., additional, Palermo, G. D., additional, Gilson, A., additional, Piront, N., additional, Heens, B., additional, Vastersaegher, C., additional, Vansteenbrugge, A., additional, Pauwels, P. C. P., additional, Abdel-Raheem, M. F., additional, Abdel-Rahman, M. Y., additional, Abdel-Gaffar, H. M., additional, Sabry, M., additional, Kasem, H., additional, Rasheed, S. M., additional, Amin, M., additional, Abdelmonem, A., additional, Ait-Allah, A. S., additional, VerMilyea, M., additional, Anthony, J., additional, Bucci, J., additional, Croly, S., additional, Coutifaris, C., additional, Cimadomo, D., additional, Dusi, L., additional, Colamaria, S., additional, Baroni, E., additional, Giuliani, M., additional, Sapienza, F., additional, Buffo, L., additional, Zivi, E., additional, Aizenman, E., additional, Barash, D., additional, Gibson, D., additional, Shufaro, Y., additional, Perez, M., additional, Aguilar, J., additional, Taboas, E., additional, Ojeda, M., additional, Suarez, L., additional, Munoz, E., additional, Casciani, V., additional, Minasi, M. G., additional, Scarselli, F., additional, Terribile, M., additional, Zavaglia, D., additional, Colasante, A., additional, Franco, G., additional, Greco, E., additional, Hickman, C., additional, Cook, C., additional, Gwinnett, D., additional, Trew, G., additional, Carby, A., additional, Lavery, S., additional, Asgari, L., additional, Paouneskou, D., additional, Jayaprakasan, K., additional, Maalouf, W., additional, Campbell, B. K., additional, Rega, E., additional, Alteri, A., additional, Cotarelo, R. P., additional, Rubino, P., additional, Colicchia, A., additional, Giannini, P., additional, Devjak, R., additional, Papler, T. B., additional, Tacer, K. F., additional, Verdenik, I., additional, Iussig, B., additional, Gala, A., additional, Ferrieres, A., additional, Vincens, C., additional, Bringer-Deutsch, S., additional, Brunet, C., additional, Conaghan, J., additional, Tan, L., additional, Gvakharia, M., additional, Ivani, K., additional, Chen, A., additional, Pera, R. R., additional, Bowman, N., additional, Montgomery, S., additional, Best, L., additional, Duffy, S., additional, Hirata, R., additional, Aoi, Y., additional, Habara, T., additional, Hayashi, N., additional, Dinopoulou, V., additional, Partsinevelos, G. A., additional, Bletsa, R., additional, Mavrogianni, D., additional, Anagnostou, E., additional, Stefanidis, K., additional, Drakakis, P., additional, Loutradis, D., additional, Hernandez, J., additional, Leon, C. L., additional, Puopolo, M., additional, Palumbo, A., additional, Atig, F., additional, Kerkeni, A., additional, D'Ommar, G., additional, Herrera, A. K., additional, Lozano, L., additional, Majerfeld, M., additional, Ye, Z., additional, Zaninovic, N., additional, Clarke, R., additional, Bodine, R., additional, Nagorny, V., additional, Zabala, A., additional, Pessino, T., additional, Outeda, S., additional, Blanco, L., additional, Leocata, F., additional, Asch, R., additional, Rajikin, M. H., additional, Nuraliza, A. S., additional, Machac, S., additional, Hubinka, V., additional, Larman, M., additional, Koudelka, M., additional, Budak, T. P., additional, Membrado, O. O., additional, Martinez, E. S., additional, Wilson, P., additional, McClure, A., additional, Nargund, G., additional, Raso, D., additional, Insua, M. F., additional, Lotti, B., additional, Giordana, S., additional, Baldi, C., additional, Barattini, J., additional, Cogorno, M., additional, Peri, N. F., additional, Neuspiller, F., additional, Resta, S., additional, Filannino, A., additional, Maggi, E., additional, Cafueri, G., additional, Ferraretti, A. P., additional, Magli, M. C., additional, Gianaroli, L., additional, Sioga, A., additional, Oikonomou, Z., additional, Chatzimeletiou, K., additional, Oikonomou, L., additional, Kolibianakis, E., additional, Tarlatzis, B. C., additional, Sarkar, M. R., additional, Ray, D., additional, Bhattacharya, J., additional, Alises, J. M., additional, Gumbao, D., additional, Hickman, C. F. L., additional, Fiorentino, I., additional, Gualtieri, R., additional, Barbato, V., additional, Braun, S., additional, Mollo, V., additional, Netti, P., additional, Talevi, R., additional, Bayram, A., additional, Findikli, N., additional, Serdarogullari, M., additional, Sahin, O., additional, Ulug, U., additional, Tosun, S. B., additional, Bahceci, M., additional, Leon, A. S., additional, Cardoso, M. C. A., additional, Aguiar, A. P. S., additional, Sartorio, C., additional, Evangelista, A., additional, Gallo-Sa, P., additional, Erthal-Martins, M. C., additional, Mantikou, E., additional, Jonker, M. J., additional, de Jong, M., additional, Wong, K. M., additional, van Montfoort, A. P. A., additional, Breit, T. M., additional, Repping, S., additional, Mastenbroek, S., additional, Power, E., additional, Jordan, K., additional, Aksoy, T., additional, Gultomruk, M., additional, Aktan, A., additional, Goktas, C., additional, Petracco, R., additional, Okada, L., additional, Azambuja, R., additional, Badalotti, F., additional, Michelon, J., additional, Reig, V., additional, Kvitko, D., additional, Tagliani-Ribeiro, A., additional, Badalotti, M., additional, Petracco, A., additional, Aydin, B., additional, Cepni, I., additional, Rodriguez-Arnedo, D., additional, Ten, J., additional, Guerrero, J., additional, Ochando, I., additional, and Bernabeu, R., additional

Published
2013
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47. Ig A pemphigus with paraneoplastic pemphigus-like clinical features showing Ig A antibodies to desmoglein 1/3 and desmocollin 3, and Ig G and Ig A antibodies to the basement membrane zone.

Author

Ueda, A., Ishii, N., Temporin, K., Yamazaki, R., Murakami, F., Fukuda, S., Hamada, T., Dainichi, T., Kyoya, M., Saito, C., Matsunaga, R., Kimura, S., Kawakami, T., Soma, Y., and Hashimoto, T.

Subjects
JAPANESE women, IMMUNOGLOBULIN A, IMMUNOGLOBULIN G, IMMUNOFLUORESCENCE, DESMOGLEINS, BASAL lamina
Abstract

A 79-year-old Japanese woman presented with severe recalcitrant erosions on her oral mucosa, resembling paraneoplastic pemphigus. Using indirect immunofluorescence, we detected Ig A antibodies against the cell surface, and both Ig G and Ig A antibodies against the basement membrane zone. Immunoblotting showed that the Ig G antibodies reacted weakly with bullous pemphigoid 230 and periplakin, whereas the Ig A antibodies did not react with any antigen. Ig A antibodies to both desmoglein (Dsg)1 and Dsg3 were detected by ELISA. Ig A antibodies to desmocollin (Dsc)3 were also detected by using cDNAs for human Dsc1-3 transfected into COS-7 cells. Despite treatment with oral prednisolone, high-dose intravenous immunoglobulin and double-filtration plasmapheresis, the skin lesions remained active, and the patient died from bronchiolitis obliterans-like respiratory failure. Despite extensive investigations and postmortem examination, no underlying neoplasms were found. The complex immunopathological findings probably played an important role in the development of the patient's unusual clinical features. [ABSTRACT FROM AUTHOR]

Published
2013
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49. Insulin resistance affects endothelium-dependent acetylcholine-induced coronary artery response.

Author

Inoue, T, Matsunaga, R, Sakai, Y, Yaguchi, I, Takayanagi, K, and Morooka, S

Abstract

Aims This study was designed to investigate the relationship between insulin resistance and the acetylcholine-induced endothelium-dependent coronary artery response in patients without angiographically significant atherosclerotic coronary artery disease and to elucidate the pathophysiological significance of insulin resistance in the early stages of coronary atherosclerosis.Methods and Results Insulin resistance was calculated from fasting plasma glucose and insulin concentration using homeostasis model assessment in 40 patients suspected of having ischaemic heart disease, but without angiographic evidence of atherosclerotic coronary artery disease defined as a discrete stenosis or intimal irregularity. They were selected for an acetylcholine provocation test in both left and right coronary arteries. The homeostasis model assessment level was higher in 16 acetylcholine-positive patients than in 24 acetylcholine-negative patients (1·84±1·24 vs 0·72±0·62, P<0·01). Comparisons of the percentage change in vessel lumen diameter after the acetylcholine test in each of proximal, mid and distal segments of three coronary arteries among the three groups of low (less than 0·7; n=13), intermediate (0·7 to 1·4; n=13), and high homeostasis model assessment level (more than 1·4; n=14) revealed that a higher level resulted in a worse acetylcholine-induced constrictive response in coronary arteries.Conclusion These results suggest that there is an association between high insulin resistance and coronary vascular endothelial cell dysfunction, and that insulin resistance may be an indicator of early stage coronary artery atherosclerosis not detectable by angiography. [ABSTRACT FROM PUBLISHER]

Published
2000
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