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Your search keyword '"Matsumoto, Michiharu"' showing total 151 results
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151 results on '"Matsumoto, Michiharu"'

4. Carcinogenicity of anthracene, 2-bromopropane, butyl methacrylate, and dimethyl hydrogen phosphite

Author

Cattley, Russell C, primary, Kromhout, Hans, additional, Sun, Meng, additional, Tokar, Erik J, additional, Abdallah, Mohamed A-E, additional, Bauer, Alison K, additional, Broadwater, Kendra R, additional, Campo, Laura, additional, Corsini, Emanuela, additional, Houck, Keith A, additional, Ichihara, Gaku, additional, Matsumoto, Michiharu, additional, Morais, Simone, additional, Mráz, Jaroslav, additional, Nomiyama, Tetsuo, additional, Ryan, Kristen, additional, Shen, Huizhong, additional, Toyoda, Takeshi, additional, Vähäkangas, Kirsi, additional, Yakubovskaya, Marianna G, additional, Yu, Il Je, additional, DeBono, Nathan L, additional, de Conti, Aline, additional, El Ghissassi, Fatiha, additional, Madia, Federica, additional, Mattock, Heidi, additional, Pasqual, Elisa, additional, Suonio, Eero, additional, Wedekind, Roland, additional, Benbrahim-Tallaa, Lamia, additional, and Schubauer-Berigan, Mary K, additional

Published
2023
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10. Clear evidence of the carcinogenic potential of anthracene: A 2‐year feeding study in rats and mice.

Author

Takeda, Tomoki, Suzuki, Masaaki, Kano, Hirokazu, Matsumoto, Michiharu, and Umeda, Yumi

Subjects
RATS, TRANSITIONAL cell carcinoma, PRECANCEROUS conditions, RENAL cell carcinoma, ANTHRACENE, ORAL drug administration, POLLUTANTS
Abstract

Anthracene is an environmental pollutant and its adverse effects on human health have long been a concern due to its persistence and bioaccumulation properties. However, there is insufficient evidence for its chronic toxicity, especially carcinogenicity, in either humans or experimental animals. In this study, its carcinogenicity and chronic toxicity were investigated in compliance with the OECD test guideline 451 (OECD TG 451) and Good Laboratory Practice Standards. Fifty male and 50 female F344 rats and 50 female BDF1 mice were administrated 0, 8000, 20000, or 50000 ppm anthracene in the diet for 104 weeks, and 50 male BDF1 mice were fed diets containing anthracene at 0, 3200, 8000, or 20000 ppm. Anthracene treatment had no adverse effect on either the survival rate or general condition of the rats or mice during the study period. Body weights were lower or tended to be lower in the anthracene‐treated groups than in the control groups. Increased incidence of hepatocellular carcinoma and hepatocellular adenoma was observed in male rats and female mice. Renal cell carcinoma and renal cell adenoma, fibroadenoma in the mammary gland, and uterine endometrial stromal sarcoma were increased in female rats. Transitional cell carcinoma and transitional cell papilloma in the urinary bladder were also increased in male and female rats. In addition, several different pre‐neoplastic lesions were increased in the anthracene‐treated male and female rats and female mice. These results provide clear evidence that oral administration of anthracene for 104 weeks has a carcinogenic effect in male and female rats and female mice. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Carcinogenicity of 1,1,1-trichloroethane and four other industrial chemicals

Author

Belpoggi, Fiorella, primary, Cattley, Russell C, additional, Reisfeld, Bradley, additional, Stewart, Patricia, additional, Turner, Michelle C, additional, Audebert, Marc, additional, Cox, Julie, additional, Ge, Calvin, additional, Gustavsson, Per, additional, Käfferlein, Heiko, additional, Lash, Lawrence, additional, Lumen, Annie, additional, Matsumoto, Michiharu, additional, Muñoz-Quezada, Maria Teresa, additional, Peters, Cheryl, additional, Purdue, Mark, additional, Svendsen, Camilla, additional, Virji, Abbas, additional, Yakubovskaya, Marianna G, additional, Yiin, James, additional, Benbrahim-Tallaa, Lamia, additional, DeBono, Nathan L, additional, de Conti, Aline, additional, El Ghissassi, Fatiha, additional, Gwinn, William, additional, Kühnle, Simone, additional, Lavoué, Jérôme, additional, Middleton, Daniel RS, additional, Miranda-Filho, Adalberto, additional, Suonio, Eero, additional, Onyije, Felix M, additional, Viegas, Susana, additional, Wedekind, Roland, additional, Goodman, Samantha, additional, Mattock, Heidi, additional, Grosse, Yann, additional, and Schubauer-Berigan, Mary K, additional

Published
2021
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17. Quantitative analysis of mutagenicity and carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in F344 gpt delta transgenic rats

Author

Gi, Min, Fujioka, Masaki, Totsuka, Yukari, Matsumoto, Michiharu, Masumura, Kenichi, Kakehashi, Anna, Yamaguchi, Takashi, Fukushima, Shoji, Wanibuchi, Hideki, Gi, Min, Fujioka, Masaki, Totsuka, Yukari, Matsumoto, Michiharu, Masumura, Kenichi, Kakehashi, Anna, Yamaguchi, Takashi, Fukushima, Shoji, and Wanibuchi, Hideki

Abstract

Quantitative analysis of the mutagenicity and carcinogenicity of the low doses of genotoxic carcinogens present in food is of pressing concern. The purpose of the present study was to determine the mutagenicity and carcinogenicity of low doses of the dietary genotoxic carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Male F344 gpt delta transgenic rats were fed diets supplemented with 0, 0.1, 1, 10, or 100 ppm IQ for 4 weeks....

Published
2019

23. Background data of spontaneous tumors in F344/DuCrlCrlj rats

Author

Takanobu, Kenji, primary, Aiso, Shigetoshi, additional, Umeda, Yumi, additional, Senoh, Hideki, additional, Saito, Misae, additional, Katagiri, Taku, additional, Ikawa, Naoki, additional, Ishikawa, Hiroaki, additional, Mine, Takashi, additional, Take, Makoto, additional, Haresaku, Mitsuru, additional, Matsumoto, Michiharu, additional, and Fukushima, Shoji, additional

Published
2015
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28. Estimation of chloroform inhalation dose by other routes based on the relationship of area under the blood concentration-time curve (AUC)-inhalation dose to chloroform distribution in the blood of rats

Author

Take, Makoto, primary, Takeuchi, Tetsuya, additional, Haresaku, Mitsuru, additional, Matsumoto, Michiharu, additional, Nagano, Kasuke, additional, Yamamoto, Seigo, additional, Takamura-Enya, Takeji, additional, and Fukushima, Shoji, additional

Published
2013
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36. Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats.

Author

Kasai, Tatsuya, Umeda, Yumi, Ohnishi, Makoto, Kondo, Hitomi, Takeuchi, Tetsuya, Aiso, Shigetoshi, Nishizawa, Tomoshi, Matsumoto, Michiharu, and Fukushima, Shoji

Subjects
CANCER risk factors, TOXICOLOGY of poisonous gases, MULTIWALLED carbon nanotubes, CARCINOGENICITY, TOXICITY testing, BRONCHOALVEOLAR lavage
Abstract

Cancer development due to fiber-like straight type of multi-walled carbon nanotubes (MWCNTs) has raised concerns for human safety because of its shape similar to asbestos. To set concentrations of MWCNT for a rat carcinogenicity study, we conducted a 13-week whole body inhalation study. F344 male and female rats, 6-week-old at the commencement of the study, were exposed by whole-body inhalation to MWCNT at concentrations of 0, 0.2, 1 and 5 mg/m3with a generation and exposure system utilizing the cyclone sieve method. Measured concentrations in the exposure chambers were 0.20 ± 0.02, 1.01 ± 0.11 and 5.02 ± 0.25 mg/m3for 13 weeks. The MMAD (GSD) of MWCNT were 1.4–1.6 μm (2.3–3.0), and mean width and length were 94.1–98.0 nm and 5.53–6.19 μm, respectively, for each target concentration. Lung weights were increased 1.2-fold with 1 mg/m3and 1.3-fold with 5 mg/m3in both sexes compared to the controls. In the bronchoalveolar lavage fluid (BALF) analyses, inflammatory parameters were increased concentration-dependently in both sexes from 0.2 mg/m3. Granulomatous changes in the lung were induced at 1 and 5 mg/m3in females and even at 0.2 mg/m3in males. Focal fibrosis of the alveolar wall was observed in both sexes at 1 mg/m3or higher. Inflammatory infiltration in the visceral pleural and subpleural areas was induced only at 5 mg/m3. In conclusion, we determined 0.2 mg/m3as the low-observed-adverse-effect level (LOAEL) for respiratory tract toxicity in the present inhalation exposure study of rats. [ABSTRACT FROM PUBLISHER]

Published
2015
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39. TWO-YEAR FEED STUDY OF CARCINOGENICITY AND CHRONIC TOXICITY OF ORTHO-CHLORONITROBENZENE IN RATS AND MICE

Author

MATSUMOTO, Michiharu, primary, UMEDA, Yumi, additional, SENOH, Hideki, additional, SUZUKI, Masaaki, additional, KANO, Hirokazu, additional, KATAGIRI, Taku, additional, AISO, Shigetoshi, additional, YAMAZAKI, Kazunori, additional, ARITO, Heihaciro, additional, NAGANO, Kasuke, additional, YAMAMOTO, Seigo, additional, and MATSUSHIMA, Taijiro, additional

Published
2006
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48. Estimation of chloroform inhalation dose by other routes based on the relationship of area under the blood concentration-time curve (AUC)-inhalation dose to chloroform distribution in the blood of rats.

Author

Take, Makoto, Takeuchi, Tetsuya, Haresaku, Mitsuru, Matsumoto, Michiharu, Nagano, Kasuke, Yamamoto, Seigo, Takamura-Enya, Takeji, and Fukushima, Shoji

Subjects
PHYSIOLOGICAL effects of chloroform, INHALATION administration, LABORATORY rats, BLOOD, ORAL medication, BODY weight, PHARMACOKINETICS
Abstract

The present study investigated the time-course changes of concentration of chloroform (CHCl3) in the blood during and after exposure of male rats to CHCl3by inhalation. Increasing the dose of CHCl3in the inhalation exposed groups caused a commensurate increase in the concentration of CHCl3in the blood and the area under the blood concentration-time curve (AUC). There was good correlation (r= 0.988) between the inhalation dose and the AUC/kg body weight. Based on the AUC/kg body weight-inhalation dose curve and the AUC/kg body weight after oral administration, inhalation equivalent doses of orally administered CHCl3were calculated. Calculation of inhalation equivalent doses allows the body burden due to CHCl3by inhalation exposure and oral exposure to be directly compared. This type of comparison facilitates risk assessment in humans exposed to CHCl3by different routes. Our results indicate that when calculating inhalation equivalent doses of CHCl3, it is critical to include the AUC from the exposure period in addition to the AUC after the end of the exposure period. Thus, studies which measure the concentration of volatile organic compounds in the blood during the inhalation exposure period are crucial. The data reported here makes an important contribution to the physiologically based pharmacokinetic (PBPK) database of CHCl3in rodents. [ABSTRACT FROM AUTHOR]

Published
2014
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