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123 results on '"Matsoukas, Konstantina"'

9. SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis

Author

Rajanala, Sai Harisha, primary, Plym, Anna, additional, Vaselkiv, Jane B, additional, Ebot, Ericka M, additional, Matsoukas, Konstantina, additional, Lin, Zhike, additional, Chakraborty, Goutam, additional, Markt, Sarah C, additional, Penney, Kathryn L, additional, Lee, Gwo-Shu M, additional, Mucci, Lorelei A, additional, Kantoff, Philip W, additional, and Stopsack, Konrad H, additional

Published
2023
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10. SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.

Author

Rajanala, Sai Harisha, Plym, Anna, Vaselkiv, Jane B, Ebot, Ericka M, Matsoukas, Konstantina, Lin, Zhike, Chakraborty, Goutam, Markt, Sarah C, Penney, Kathryn L, Lee, Gwo-Shu M, Mucci, Lorelei A, Kantoff, Philip W, and Stopsack, Konrad H

Abstract

Solute carrier organic anion (SLCO) transporters (OATP transporters) are involved in cellular uptake of drugs and hormones. Germline variants in SLCO1B3 and SLCO2B1 have been implicated in prostate cancer progression and therapy response, including to androgen deprivation and statin medications, but results have appeared heterogeneous. We conducted a cohort study of five single-nucleotide polymorphisms (SNPs) in SLCO1B3 and SLCO2B1 with prior evidence among 3208 men with prostate cancer who participated in the Health Professionals Follow-up Study or the Physicians' Health Study, following participants prospectively after diagnosis over 32 years (median, 14 years) for development of metastases and cancer-specific death (lethal disease, 382 events). Results were suggestive of, but not conclusive for, associations between some SNPs and lethal disease and differences by androgen deprivation and statin use. All candidate SNPs were associated with SLCO mRNA expression in tumor-adjacent prostate tissue. We also conducted a systematic review and harmonized estimates for a dose-response meta-analysis of all available data, including 9 further studies, for a total of 5598 patients and 1473 clinical events. The A allele of the exonic SNP rs12422149 (14% prevalence), which leads to lower cellular testosterone precursor uptake via SLCO2B1, was associated with lower rates of prostate cancer progression (hazard ratio per A allele, 0.80; 95% confidence interval, 0.69–0.93), with little heterogeneity between studies (I 2, 0.27). Collectively, the totality of evidence suggests a strong association between inherited genetic variation in SLCO2B1 and prostate cancer prognosis, with potential clinical use in risk stratification related to androgen deprivation therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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16. List of contributors

Author

Belter, Christopher W., primary, Boyce, Lindsay M., additional, Delgado, Diana, additional, Demetres, Michelle, additional, DeRosa, Antonio P., additional, Federer, Lisa, additional, Gibson, Donna S., additional, Jewell, Sarah T., additional, Martin, Lily K., additional, Matsoukas, Konstantina, additional, and Pinotti, Rachel, additional

Published
2018
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19. Abstract 1438: Organic anion transporter(SLCO)genotype and prostate cancer progression: Prospective cohort study and meta-analysis

Author

Stopsack, Konrad H., primary, Rajanala, Harisha, additional, Plym, Anna, additional, Vaselkiv, Jane B., additional, Matsoukas, Konstantina, additional, Ebot, Ericka M., additional, Markt, Sarah C., additional, Penney, Kathryn L., additional, Lee, Gwo-Shu M., additional, Mucci, Lorelei A., additional, and Kantoff, Philip W., additional

Published
2022
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21. Additional file 3 of COVID-19 double jeopardy: the overwhelming impact of the social determinants of health

Author

Badalov, Elizabeth, Blackler, Liz, Scharf, Amy E., Matsoukas, Konstantina, Chawla, Sanjay, Voigt, Louis P., and Kuflik, Arthur

Subjects
surgical procedures, operative, digestive system, digestive system diseases
Abstract

Additional file 3: Appendix C. Disproportionate COVID-19 Attack and Fatality Rates in Minority Populations Across the US.

Published
2022
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29. Call to action: empowering patients and families to initiate clinical ethics consultations

Author

Blackler, Liz, Scharf, Amy E, Matsoukas, Konstantina, Colletti, Michelle, and Voigt, Louis P

Abstract

Clinical ethics consultations exist to support patients, families and clinicians who are facing ethical or moral challenges related to patient care. They provide a forum for open communication, where all stakeholders are encouraged to express their concerns and articulate their viewpoints. Ethics consultations can be requested by patients, caregivers or members of a patient’s clinical or supportive team. Although patientsand by extension their families (especially in cases of decisional incapacity) are the common denominators in most ethics consultations, these constituents are the leastlikely to request them. At many healthcare organisations in the USA, ethics consultations are overwhelmingly requested by physicians and other clinicians. We believe it is vital that healthcare institutions bridge the knowledge gaps and power imbalances over access to ethics consultation services through augmented policies, procedures and infrastructure. With enhanced education and support, patients and families may use ethics consultation to elevate their voices and prioritise their unique characteristics and preferences in the delivery of their healthcare. Empowering patients and families to request ethics consultation can only strengthen the patient/family–clinician relationship, enhance the shared decision-making model of care and ultimately lead to improved patient-centred care.

Published
2023
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31. Staff Experiences at a New York City Medical Center During the Spring Peak of the Covid-19 Pandemic: A Qualitative Study

Author

Blackler, Liz, primary, Scharf, Amy E., additional, Masciale, James N., additional, Lynch, Kathleen A., additional, Riches, Jamie C., additional, Matsoukas, Konstantina, additional, Colletti, Michelle, additional, Wall, Lisa, additional, Chawla, Sanjay, additional, Coyle, Nessa, additional, Alici, Yesne, additional, Guest, Rebecca, additional, and Voigt, Louis P., additional

Published
2021
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32. Psychosocial interventions and needs among individuals and families with Li‐Fraumeni syndrome: A scoping review.

Author

Barnett, Marie, Breen, Kelsey E., Kennedy, Jennifer A., Hernandez, Marisol, Matsoukas, Konstantina, and MacGregor, Meredith

Subjects
LI-Fraumeni syndrome, YOUNG adults, GENETIC testing, INDIVIDUAL needs, MEDICAL screening
Abstract

Li‐Fraumeni syndrome (LFS), a rare cancer predisposition syndrome caused by germline mutations in the TP53 gene, is associated with significant lifetime risk of developing cancer and warrants extensive and long‐term surveillance. There are psychosocial impacts on individuals and families living with this condition, from the initial diagnosis throughout multiple stages across the lifespan, but these impacts have not been systematically reviewed and organized. The objective of this scoping review was to synthesize and characterize the literature on psychosocial screening and outcomes, educational needs, support services, and available interventions for patients and families with LFS. A systematic search of six databases was most recently conducted in August 2020: (PubMed/MEDLINE (NLM), EMBASE (Elsevier), Cochrane Library (Wiley), CINAHL (EBSCO), PsycINFO (OVID), and Web of Science (Clarivate Analytics). A total of 15 757 titles were screened, and 24 articles included. Several important themes were identified across studies: factors associated with TP53 genetic testing, LFS surveillance, psychological outcomes, and communication. Findings related to these themes were organized into age‐specific categories (age agnostic/across the lifespan, childhood, adolescence and young adulthood, and adulthood). [ABSTRACT FROM AUTHOR]

Published
2022
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36. What Should Clinicians Do When a Patient's Autonomy Undermines Her Being Treated Equitably?

Author

Scharf, Amy, Voigt, Louis, Vardhana, Santosha, Matsoukas, Konstantina, Wall, Lisa M., Arevalo, Maria, and Diamond, Lisa C.

Subjects
COMMUNICATION, DECISION making, FAMILIES, HEALTH services accessibility, LANGUAGE & languages, PHYSICIAN-patient relations, PHYSICIANS, HEALTH facility translating services, OCCUPATIONAL roles, CULTURAL competence, PATIENT autonomy
Abstract

Language and cultural barriers can impede communication between patients and clinicians, exacerbating health inequity. Additional complications can arise when family members, intending to protect their loved ones, ask clinicians to lie or not disclose to patients their diagnoses, prognoses, or intervention options. Clinicians must express respect for patients' and families' cultural, religious, and social norms regarding health care decision making, but they might also be ethically troubled by some decisions' effects on patients' health outcomes. This article suggests strategies for clinicians trying to overcome linguistic and cultural barriers to equitable patient care. [ABSTRACT FROM AUTHOR]

Published
2021
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38. Corrigendum to “Antidepressants appear safe in patients with carcinoid tumor: Results of a retrospective review” [YEJSO 44 (6) (June 2018) 744–749]

Author

Isenberg-Grzeda, Elie, primary, MacGregor, Meredith, additional, Bergel, Afton, additional, Eagle, Stacy, additional, Espi Forcen, Fernando, additional, Mehta, Reema, additional, Matsoukas, Konstantina, additional, Wills, Jonathan, additional, Reidy-Lagunes, Diane, additional, and Alici, Yesne, additional

Published
2018
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39. Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis

Author

Scott, Jessica M., primary, Zabor, Emily C., additional, Schwitzer, Emily, additional, Koelwyn, Graeme J., additional, Adams, Scott C., additional, Nilsen, Tormod S., additional, Moskowitz, Chaya S., additional, Matsoukas, Konstantina, additional, Iyengar, Neil M., additional, Dang, Chau T., additional, and Jones, Lee W., additional

Published
2018
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48. Assessing the Health Science Information Needs of Unaffiliated Health Professionals and Using Training on Openly-Available Search Tools and Resources to Provide Solutions

Author

Matsoukas, Konstantina, Koehn, Michael D., and Hauser, Diane

Subjects
Library science
Abstract

An institute for Family health located in Manhattan, the Bronx, and the Mid-Hudson Valley. It operates 15 full-time and 9 part-time health centers as well as employ ~66 physicians, NPs, social workers, health educators, and nursing staff. The aims of this project is to determine the medical literature and training needs of IFH personnel, develop generic licensing agreements and develop reference and education services for the IFH staff. IFH services serves of 72,000 patients and provides 225,000 patient visits annually. They also provide care regardless of ability to pay.

Published
2012
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