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4 results on '"Matsigkou, E"'

1. MuSK autoantibodies in myasthenia gravis detected by cell based assay — A multinational study

Author

Tsonis, A.I., Zisimopoulou, P., Lazaridis, K., Tzartos, J., Matsigkou, E., Zouvelou, V., Mantegazza, R., Antozzi, C., Andreetta, F., Evoli, A., Deymeer, F., Saruhan-Direskeneli, G., Durmus, H., Brenner, T., Vaknin, A., Berrih-Aknin, S., Behin, A., Sharshar, T., De Baets, M., Losen, M., Martinez-Martinez, P., Kleopa, K.A., Zamba-Papanicolaou, E., Kyriakides, T., Kostera-Pruszczyk, A., Szczudlik, P., Szyluk, B., Lavrnic, D., Basta, I., Peric, S., Tallaksen, C., Maniaol, A., Casasnovas Pons, C., Pitha, J., Jakubíkova, M., Hanisch, F., and Tzartos, S.J.

Published
2015
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2. AChR-myasthenia gravis switching to double-seropositive several years after the onset

Author

Zouvelou, V. Zisimopoulou, P. Psimenou, E. Matsigkou, E. Stamboulis, E. Tzartos, S.J.

Abstract

We report an early onset AChR-myasthenia gravis (MG) with biphasic clinical course. The clinical "switch" from AChR-MG to MuSK-MG emerged 16 years after the onset and 11 years after thymectomy. MuSK antibodies were detected only by cell-based assay and only upon clinical "switch", while AChR antibodies remained positive and at high titers during the whole disease course. Although the occurrence of AChR antibodies and MuSK antibodies in the same individual is rare, the re-assessment of the antibody status, using all available assays, is advisable when there is clinical indication. © 2013 Elsevier B.V.

Published
2014

3. MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study

Author

Evoli Stampanoni-B, Amelia, Tsonis, A, Zisimopoulou, P, Matsigkou, E, Lazaridis, K, Tzartos, J, Zouvelou, Vasiliki, Mantegazza, Renato, Antozzi, Carlo, Deymeer, Feza, Saruhan Direskeneli, G, Durmus, H, Brenner, T, Vaknin, A, Behin, A, Berrih Aknin, S, Sharshar, T, De Baets, Mark, Martinez Martinez, P, Losen, Mario, Zamba Papanicolaou, E, Kleopa, Ka, Kyriakides, T, Kostera Pruszczyk, A, Szczudlik, P, Szyluk, B, Lavrnic, D, Basta, I, Peric, S, Tallaksen, Chantal, Maniaol, A, Casasnovas Pons, C, Pitha, J, Jakubíkova, M, Hanisch, F, Tzartos, Sj, Andreetta, F, Evoli, Amelia (ORCID:0000-0003-0282-8787), Evoli Stampanoni-B, Amelia, Tsonis, A, Zisimopoulou, P, Matsigkou, E, Lazaridis, K, Tzartos, J, Zouvelou, Vasiliki, Mantegazza, Renato, Antozzi, Carlo, Deymeer, Feza, Saruhan Direskeneli, G, Durmus, H, Brenner, T, Vaknin, A, Behin, A, Berrih Aknin, S, Sharshar, T, De Baets, Mark, Martinez Martinez, P, Losen, Mario, Zamba Papanicolaou, E, Kleopa, Ka, Kyriakides, T, Kostera Pruszczyk, A, Szczudlik, P, Szyluk, B, Lavrnic, D, Basta, I, Peric, S, Tallaksen, Chantal, Maniaol, A, Casasnovas Pons, C, Pitha, J, Jakubíkova, M, Hanisch, F, Tzartos, Sj, Andreetta, F, and Evoli, Amelia (ORCID:0000-0003-0282-8787)

Abstract

Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.

Published
2015

4. AChR-myasthenia gravis switching to double-seropositive several years after the onset.

Author

Zouvelou V, Zisimopoulou P, Psimenou E, Matsigkou E, Stamboulis E, and Tzartos SJ

Subjects
Adult, Disease Progression, Female, Humans, Longitudinal Studies, Autoantibodies blood, Myasthenia Gravis immunology, Myasthenia Gravis metabolism, Receptors, Cholinergic immunology
Abstract

We report an early onset AChR-myasthenia gravis (MG) with biphasic clinical course. The clinical "switch" from AChR-MG to MuSK-MG emerged 16 years after the onset and 11 years after thymectomy. MuSK antibodies were detected only by cell-based assay and only upon clinical "switch", while AChR antibodies remained positive and at high titers during the whole disease course. Although the occurrence of AChR antibodies and MuSK antibodies in the same individual is rare, the re-assessment of the antibody status, using all available assays, is advisable when there is clinical indication., (Copyright © 2013 Elsevier B.V. All rights reserved.)

Published
2014
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