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1. Analysis of diagnostic test outcomes in a large loiasis cohort from an endemic region: Serological tests are often false negative in hyper-microfilaremic infections

Author

Veletzky, Luzia, primary, Eberhardt, Kirsten Alexandra, additional, Hergeth, Jennifer, additional, Stelzl, Daniel Robert, additional, Zoleko Manego, Rella, additional, Kreuzmair, Ruth, additional, Burger, Gerrit, additional, Mischlinger, Johannes, additional, McCall, Matthew B. B., additional, Mombo-Ngoma, Ghyslain, additional, Adegnika, Ayôla Akim, additional, Agnandji, Selidji Todagbe, additional, Matsiegui, Pierre Blaise, additional, Lell, Bertrand, additional, Kremsner, Peter, additional, Mordmüller, Benjamin, additional, Tappe, Dennis, additional, and Ramharter, Michael, additional

Published
2024
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3. Making clinical trials a public norm for health decisions in sub-Saharan Africa.

Author

Agnandji, Selidji T., Loembe, Marguerite Massinga, Mbouna, Armel V., Mbadinga, Fallowne, Essone, Paulin N., Mombo-Ngoma, Ghyslain, Leke, Rose, Mburu, Yvonne K., Muyembe-Tamfum, Jean-Jacques, Okwo-Bele, Jean-Marie, Sow, Samba, Wiysonge, Charles Shey, Zumla, Alimuddin, Adegnika, Ayola A., Ramharter, Michael, Kremsner, Peter G., Matsiegui, Pierre-Blaise, Boum, Yap, and Ntoumi, Francine

Published
2024
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4. Urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in Gabon

Author

Mombo-Ngoma, Ghyslain, Honkpehedji, Josiane, Basra, Arti, Mackanga, Jean Rodolphe, Zoleko, Rella Manego, Zinsou, Jeannot, Agobe, Jean Claude Dejon, Lell, Bertrand, Matsiegui, Pierre-Blaise, Gonzales, Raquel, Agnandji, Selidji Todagbe, Yazdanbakhsh, Maria, Menendez, Clara, Kremsner, Peter G., Adegnika, Ayola Akim, and Ramharter, Michael

Published
2017
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6. Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon

Author

Veletzky, Luzia, primary, Eberhardt, Kirsten Alexandra, additional, Hergeth, Jennifer, additional, Stelzl, Daniel Robert, additional, Zoleko Manego, Rella, additional, Mombo-Ngoma, Ghyslain, additional, Kreuzmair, Ruth, additional, Burger, Gerrit, additional, Adegnika, Ayôla Akim, additional, Agnandji, Selidji Todagbe, additional, Matsiegui, Pierre Blaise, additional, Boussinesq, Michel, additional, Mordmüller, Benjamin, additional, and Ramharter, Michael, additional

Published
2022
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7. Corrigendum to: Molecular Epidemiology of Mansonella Species in Gabon

Author

Sandri, Thaisa Lucas, primary, Kreidenweiss, Andrea, additional, Cavallo, Simon, additional, Weber, David, additional, Juhas, Sascha, additional, Rodi, Miriam, additional, Woldearegai, Tamirat Gebru, additional, Gmeiner, Markus, additional, Veletzky, Luzia, additional, Ramharter, Michael, additional, Tazemda-Kuitsouc, Gildas B, additional, Matsiegui, Pierre Blaise, additional, Mordmüller, Benjamin, additional, and Held, Jana, additional

Published
2022
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11. Diagnostic performance of capillary and venous blood samples in the detection of Loa loa and Mansonella perstans microfilaraemia using light microscopy

Author

Mischlinger, Johannes, primary, Manego, Rella Zoleko, additional, Mombo-Ngoma, Ghyslain, additional, Ekoka Mbassi, Dorothea, additional, Hackbarth, Nina, additional, Ekoka Mbassi, Franck-Aurelien, additional, Davi, Saskia Dede, additional, Kreuzmair, Ruth, additional, Veletzky, Luzia, additional, Hergeth, Jennifer, additional, Ndoumba, Wilfrid Nzebe, additional, Pitzinger, Paul, additional, Groger, Mirjam, additional, Matsiegui, Pierre Blaise, additional, Adegnika, Ayôla Akim, additional, Agnandji, Selidji Todagbe, additional, Lell, Bertrand, additional, and Ramharter, Michael, additional

Published
2021
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13. Evaluation of intermittent preventive treatment of malaria against group B Streptococcus colonization in pregnant women: a nested analysis of a randomized controlled clinical trial of sulfadoxine/pyrimethamine versus mefloquine

Author

Capan-Melser, Mesküre, Mombo Ngoma, Ghyslain, Akerey-Diop, Daisy, Basra, Arti, Würbel, Heike, Groger, Mirjam, Mackanga, Jean R., Zoleko-Manego, Rella, Schipulle, Ulla, Schwing, Julia, Lötsch, Felix, Rehman, Khalid, Matsiegui, Pierre-Blaise, Agnandji, Selidji T., Adegnika, Ayôla A., Bélard, Sabine, González, Raquel, Kremsner, Peter G., Menendez, Clara, and Ramharter, Michael

Published
2015
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14. Loa loa infection in pregnant women, Gabon

Author

Mombo-Ngoma, Ghyslain, Mackanga, Jean Rodolphe, Basra, Arti, Capan, Meskure, Manego, Rella Zoleko, Adegnika, Ayola Akim, Lotsch, Felix, Yazdanbakhsh, Maria, Gonzalez, Raquel, Menendez, Clara, Mabika, Barthelemy, Matsiegui, Pierre Blaise, Kremsner, Peter G., and Ramharter, Michael

Subjects
Health
Abstract

To the Editor: Loa loa, the African eye worm, is a filarial pathogen of Central African rainforest regions. As of 2013, it had affected an estimated 2-3 million persons in [...]

Published
2015

16. Birth weight, growth, nutritional status and mortality of infants from Lambaréné and Fougamou in Gabon in their first year of life

Author

Zoleko-Manego, Rella, primary, Mischlinger, Johannes, additional, Dejon-Agobé, Jean Claude, additional, Basra, Arti, additional, Mackanga, J. Rodolphe, additional, Akerey Diop, Daisy, additional, Adegnika, Ayola Akim, additional, Agnandji, Selidji T., additional, Lell, Bertrand, additional, Kremsner, Peter G., additional, Matsiegui, Pierre Blaise, additional, González, Raquel, additional, Menendez, Clara, additional, Ramharter, Michael, additional, and Mombo-Ngoma, Ghyslain, additional

Published
2021
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19. Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial

Author

Ramharter, Michael, Oyakhirome, Sunny, Klouwenberg, Peter Klein, Adegnika, Ayola A., Agnandji, Selidji T., Missinou, Michel A., Matsiegui, Pierre-Blaise, Mordmuller, Benjamin, Borrmann, Steffen, Kun, Jurgen F., Lell, Bertrand, Krishna, Sanjeev, Graninger, Wolfgang, Issifou, Saadou, and Kremsner, Peter G.

Subjects
Quinine -- Dosage and administration, Malaria -- Drug therapy, Clindamycin -- Dosage and administration, Health, Health care industry
Published
2005

20. Molecular Epidemiology of Mansonella Species in Gabon

Author

Sandri, Thaisa Lucas, primary, Kreidenweiss, Andrea, additional, Cavallo, Simon, additional, Weber, David, additional, Juhas, Sascha, additional, Rodi, Miriam, additional, Woldearegai, Tamirat Gebru, additional, Gmeiner, Markus, additional, Veletzky, Luzia, additional, Ramharter, Michael, additional, Tazemda-Kuitsouc, Gildas B, additional, Matsiegui, Pierre Blaise, additional, Mordmüller, Benjamin, additional, and Held, Jana, additional

Published
2020
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22. Efficacy of atovaquone/proguanil for malaria prophylaxis in children and its effect on the immunogenicity of live oral typhoid and cholera vaccines. (Major Article)

Author

Faucher, Jean-Francois, Binder, Ronnie, Missinou, Michel A., Matsiegui, Pierre-Blaise, Gruss, Holger, Neubauer, Rajko, Lell, Bertrand, Que, John U., Miller, Gerri B., and Kremsner, Peter G.

Subjects
Malaria -- Drug therapy, Antimalarials -- Evaluation, Atovaquone -- Evaluation, Proguanil -- Evaluation, Typhoid vaccine -- Physiological aspects, Bacterial vaccines -- Physiological aspects, Health, Health care industry
Published
2002

23. Antibody responses to Plasmodium falciparum merozoite surface protein--1 and efficacy of amodiaquine in Gabonese children with P. falciparum Malaria. (Major Article)

Author

Mawili-Mboumba, Denise P., Borrmann, Steffen, Cavanagh, David R., McBride, Jana S., Matsiegui, Pierre-Blaise, Missinou, Michel A., Kremsner, Peter G., and Ntoumi, Francine

Subjects
Communicable diseases -- Research, Plasmodium falciparum -- Research, Malaria -- Drug therapy, Drug resistance in microorganisms -- Research, Antimalarials -- Evaluation, Antimalarials -- Usage, Health
Published
2003

24. Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

Author

Ramharter, Michael, primary, Schwab, Matthias, additional, Mombo-Ngoma, Ghyslain, additional, Zoleko Manego, Rella, additional, Akerey-Diop, Daisy, additional, Basra, Arti, additional, Mackanga, Jean-Rodolphe, additional, Würbel, Heike, additional, Wojtyniak, Jan-Georg, additional, Gonzalez, Raquel, additional, Hofmann, Ute, additional, Geditz, Mirjam, additional, Matsiegui, Pierre-Blaise, additional, Kremsner, Peter G., additional, Menendez, Clara, additional, Kerb, Reinhold, additional, and Lehr, Thorsten, additional

Published
2019
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25. Phase I randomized dose-ascending placebo-controlled trials of ferroquine - a candidate anti-malarial drug - in adults with asymptomatic Plasmodium falciparum infection

Author

Ospina Salazar Carmen L, Matsiegui Pierre-Blaise, Missinou Michel A, Dal-Bianco Matthias P, Supan Christian, Mombo-Ngoma Ghyslain, Issifou Saadou, Ter-Minassian Daniel, Ramharter Michael, Kombila Maryvonne, Kremsner Peter G, and Lell Bertrand

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The development and spread of drug resistant Plasmodium falciparum strains is a major concern and novel anti-malarial drugs are, therefore, needed. Ferroquine is a ferrocenic derivative of chloroquine with proven anti-malarial activity against chloroquine-resistant and -sensitive P. falciparum laboratory strains. Methods Adult young male aged 18 to 45 years, asymptomatic carriers of P. falciparum, were included in two-dose escalation, double-blind, randomized, placebo-controlled Phase I trials, a single dose study and a multiple dose study aiming to evaluate oral doses of ferroquine from 400 to 1,600 mg. Results Overall, 54/66 patients (40 and 26 treated in the single and multiple dose studies, respectively) experienced at least one adverse event, 15 were under placebo. Adverse events were mainly gastrointestinal symptoms such as abdominal pain (16), diarrhoea (5), nausea (13), and vomiting (9), but also headache (11), and dizziness (5). A few patients had slightly elevated liver parameters (10/66) including two patients under placebo. Moderate changes in QTc and morphological changes in T waves were observed in the course of the study. However, no adverse cardiac effects with clinical relevance were observed. Conclusions These phase I trials showed that clinically, ferroquine was generally well-tolerated up to 1,600 mg as single dose and up to 800 mg as repeated dose in asymptomatic young male with P. falciparum infection. Further clinical development of ferroquine, either alone or in combination with another anti-malarial, is highly warranted and currently underway.

Published
2011
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26. Molecular Epidemiology of Mansonella Species in Gabon.

Author

Sandri, Thaisa Lucas, Kreidenweiss, Andrea, Cavallo, Simon, Weber, David, Juhas, Sascha, Rodi, Miriam, Woldearegai, Tamirat Gebru, Gmeiner, Markus, Veletzky, Luzia, Ramharter, Michael, Tazemda-Kuitsouc, Gildas B, Matsiegui, Pierre Blaise, Mordmüller, Benjamin, and Held, Jana

Subjects
MOLECULAR epidemiology, FILARIASIS, SPECIES, PLANT nematodes, WOLBACHIA
Abstract

Mansonella perstans, a filarial nematode, infects large populations in Africa and Latin America. Recently, a potential new species, Mansonella sp "DEUX," was reported. Carriage of endosymbiotic Wolbachia opens treatment options for Mansonella infections. Within a cross-sectional study, we assessed the prevalence of filarial infections in 834 Gabonese individuals and the presence of the endosymbiont Wolbachia. Almost half of the participants (400/834 [48%]) were infected with filarial nematodes, with Mansonella sp "DEUX" being the most frequent (295/400 [74%]), followed by Loa loa (273/400 [68%]) and Mansonella perstans (82/400 [21%]). Being adult/elderly, male, and living in rural areas was associated with a higher risk of infection. Wolbachia carriage was confirmed in M. perstans and Mansonella sp "DEUX." In silico analysis revealed that Mansonella sp "DEUX" is not detected with currently published M. perstans-specific assays. Mansonella infections are highly prevalent in Gabon and might have been underreported, likely also beyond Gabon. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Prevalence of Plasmodium falciparum infection in pregnant women in Gabon

Author

Kendjo Eric, Ionete-Collard Denisa E, Mabika-Manfoumbi Modeste, Bouyou-Akotet Marielle K, Matsiegui Pierre-Blaise, Mavoungou Elie, and Kombila Maryvonne

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In areas where malaria is endemic, pregnancy is associated with increased susceptibility to malaria. It is generally agreed that this risk ends with delivery and decreases with the number of pregnancies. Our study aimed to demonstrate relationships between malarial parasitaemia and age, gravidity and anaemia in pregnant women in Libreville, the capital city of Gabon. Methods Peripheral blood was collected from 311 primigravidae and women in their second pregnancy. Thick blood smears were checked, as were the results of haemoglobin electrophoresis. We also looked for the presence of anaemia, fever, and checked whether the volunteers had had chemoprophylaxis. The study was performed in Gabon where malaria transmission is intense and perennial. Results A total of 177 women (57%) had microscopic parasitaemia; 139 (64%)of them were primigravidae, 38 (40%) in their second pregnancy and 180 (64%) were teenagers. The parasites densities were also higher in primigravidae and teenagers. The prevalence of anaemia was 71% and was associated with microscopic Plasmodium falciparum parasitaemia: women with moderate or severe anaemia had higher parasite prevalences and densities. However, the sickle cell trait, fever and the use of chemoprophylaxis did not have a significant association with the presence of P. falciparum. Conclusions These results suggest that the prevalence of malaria and the prevalence of anaemia, whether associated with malaria or not, are higher in pregnant women in Gabon. Primigravidae and young pregnant women are the most susceptible to infection. It is, therefore, urgent to design an effective regimen of malaria prophylaxis for this high risk population.

Published
2003
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28. Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon

Author

Groger, Mirjam, primary, Veletzky, Luzia, additional, Lalremruata, Albert, additional, Cattaneo, Chiara, additional, Mischlinger, Johannes, additional, Zoleko-Manego, Rella, additional, Endamne, Lilian, additional, Klicpera, Anna, additional, Kim, Johanna, additional, Nguyen, The, additional, Flohr, Lena, additional, Remppis, Jonathan, additional, Matsiegui, Pierre-Blaise, additional, Adegnika, Ayôla A., additional, Agnandji, Selidji T., additional, Kremsner, Peter G., additional, Mordmüller, Benjamin, additional, Mombo-Ngoma, Ghyslain, additional, and Ramharter, Michael, additional

Published
2018
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29. Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa

Author

Belard, Sabine, Toepfner, Nicole, Capan-Melser, Mesküre, Mombo-Ngoma, Ghyslain, Zoleko-Manego, Rella, Groger, Mirjam, Matsiegui, Pierre-Blaise, Agnandji, Selidji Todagbe, Adegnika, Ayôla A., González, Raquel, Kremsner, Peter G., Menéndez, Clara, Ramharter, Michael, and Berner, Reinhard

Subjects
DNA, Bacterial, Clindamycin, Pregnant women, Streptococcus, Estreptococs, Microbial Sensitivity Tests, Penicillins, Serogroup, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit, Article, Anti-Bacterial Agents, Streptococcus agalactiae, Embarassades, Antibacterial agents, Pregnancy, Streptococcal Infections, Drug Resistance, Bacterial, Vagina, Humans, Female, Medicaments antibacterians, Gabon, Multiplex Polymerase Chain Reaction
Abstract

Neonatal invasive disease due to Streptococcus agalactiae is life threatening and preventive strategies suitable for resource limited settings are urgently needed. Protective coverage of vaccine candidates based on capsular epitopes will relate to local epidemiology of S. agalactiae serotypes and successful management of critical infections depends on timely therapy with effective antibiotics. This is the first report on serotype distribution and antimicrobial susceptibility of S. agalactiae in pregnant women from a Central African region. Serotypes V, III, and Ib accounted for 88/109 (81%) serotypes and all isolates were susceptible to penicillin and clindamycin while 13% showed intermediate susceptibility to erythromycin.

Published
2015

30. Fosmidomycin for malaria. (Research Letters)

Author

Missinou, Michel A, Borrmann, Steffen, Schindler, Andreas, Issifou, Saadou, Adegnika, Ayola A, Matsiegui, Pierre-Blaise, Binder, Ronald, Lell, Bertrand, Wiesner, Jochen, Baranek, Thomas, Jomaa, Hassan, and Kremsner, Peter G

Subjects
Malaria -- Drug therapy, Antimalarials -- Evaluation
Published
2002

31. CD4+CD25hiFOXP3+ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4+Tbet+ and CD4+RORγt+ T cells

Author

Ateba-Ngoa, Ulysse, Mombo-Ngoma, Ghyslain, Zettlmeissl, Eva, van der Vlugt, Luciën E. P. M., de Jong, Sanne, Matsiegui, Pierre-Blaise, Ramharter, Michael, Kremsner, Peter G., Yazdanbakhsh, Maria, and Adegnika, Ayola Akim

Subjects
Infectious Diseases, Immunology, lcsh:R, Medicine and Health Sciences, Parasitic Diseases, Biology and Life Sciences, lcsh:Medicine, Parasitology, lcsh:Q, Cell Biology, Tropical Diseases, lcsh:Science, Research Article
Abstract

Background Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers. Moreover children from filaria infected mothers have been shown to be less responsive to vaccination as a consequence of an impairment of their immune response. However, it is not well known how in utero exposure to parasite antigens affects cellular immune responses. Methodology Here, 30 pregnant women were examined for the presence of microfilaria of Loa loa and Mansonella perstans in peripheral blood. At delivery, cord blood mononuclear cells (CBMC) were obtained and the CD4+T cells were phenotyped by expression of the transcription factors Tbet, RORγt, and FOXP3. Results No significant difference was observed between newborns from infected versus uninfected mothers in the frequencies of total CD4+T cells and CD4+T cells subsets including CD4+Tbet+, CD4+RORγt+ T and CD4+CD25hiFOXP3+ T cells. However, there was a negative association between CD4+CD25hiFOXP3+T cells and CD4+Tbet+ as well as CD4+RORγt+ T cells in the infected group only (B = −0.242, P = 0.002; B = −0.178, P = 0.013 respectively). Conclusion Our results suggest that filarial infection during pregnancy leads to an expansion of functionally active regulatory T cells that keep TH1 and TH17 in check.

Published
2014

32. Malaria in urban, semi-urban and rural areas of southern of Gabon: comparison of the Pfmdr 1 and Pfcrt genotypes from symptomatic children

Author

Maghendji-Nzondo, Sydney, primary, Kouna, Lady-Charlène, additional, Mourembou, Gaël, additional, Boundenga, Larson, additional, Imboumy-Limoukou, Romeo-Karl, additional, Matsiegui, Pierre-Blaise, additional, Manego-Zoleko, Rella, additional, Mbatchi, Bertrand, additional, Raoult, Didier, additional, Toure-Ndouo, Fousseyni, additional, and Lekana-Douki, Jean Bernard, additional

Published
2016
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33. Co-circulation of Plasmodium and Bacterial DNAs in Blood of Febrile and Afebrile Children from Urban and Rural Areas in Gabon

Author

Mourembou, Gaël, primary, Kouna, Lady Charlène, additional, Matsiegui, Pierre Blaise, additional, Keïta, Alpha Kabinet, additional, Ndjoyi-Mbiguino, Angélique, additional, Raoult, Didier, additional, Nzondo, Sydney Maghendji, additional, Lekana-Douki, Jean Bernard, additional, Manego, Rella Zoleko, additional, Tissot-Dupont, Hervé, additional, Moukandja, Irene Pegha, additional, and Fenollar, Florence, additional

Published
2016
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34. Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study

Author

Mombo-Ngoma, Ghyslain, primary, Mackanga, Jean Rodolphe, additional, González, Raquel, additional, Ouedraogo, Smaila, additional, Kakolwa, Mwaka A, additional, Manego, Rella Zoleko, additional, Basra, Arti, additional, Rupérez, María, additional, Cot, Michel, additional, Kabanywany, Abdunoor M, additional, Matsiegui, Pierre-Blaise, additional, Agnandji, Seldiji T, additional, Vala, Anifa, additional, Massougbodji, Achille, additional, Abdulla, Salim, additional, Adegnika, Ayôla A, additional, Sevene, Esperança, additional, Macete, Eusebio, additional, Yazdanbakhsh, Maria, additional, Kremsner, Peter G, additional, Aponte, John J, additional, Menéndez, Clara, additional, and Ramharter, Michael, additional

Published
2016
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35. Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa

Author

Belard, Sabine, primary, Toepfner, Nicole, additional, Capan-Melser, Mesküre, additional, Mombo-Ngoma, Ghyslain, additional, Zoleko-Manego, Rella, additional, Groger, Mirjam, additional, Matsiegui, Pierre-Blaise, additional, Agnandji, Selidji T., additional, Adegnika, Ayôla A., additional, González, Raquel, additional, Kremsner, Peter G., additional, Menendez, Clara, additional, Ramharter, Michael, additional, and Berner, Reinhard, additional

Published
2015
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36. Mansonella, including a Potential New Species, as Common Parasites in Children in Gabon

Author

Mourembou, Gaël, primary, Fenollar, Florence, additional, Lekana-Douki, Jean Bernard, additional, Ndjoyi Mbiguino, Angelique, additional, Maghendji Nzondo, Sydney, additional, Matsiegui, Pierre Blaise, additional, Zoleko Manego, Rella, additional, Ehounoud, Cyrille Herve Bile, additional, Bittar, Fadi, additional, Raoult, Didier, additional, and Mediannikov, Oleg, additional

Published
2015
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37. Epidemiology of Human Herpes Virus 8 in Pregnant Women and their Newborns - A cross-sectional delivery survey in Central Gabon

Author

Capan-Melser, Mesküre, primary, Mombo-Ngoma, Ghyslain, additional, Akerey-Diop, Daisy, additional, Basra, Arti, additional, Manego-Zoleko, Rella, additional, Würbel, Heike, additional, Lötsch, Felix, additional, Groger, Mirjam, additional, Skoll, Michael, additional, Schwing, Julia, additional, Schipulle, Ulla, additional, Matsiegui, Pierre-Blaise, additional, González, Raquel, additional, Menendez, Clara, additional, Kremsner, Peter G., additional, Adegnika, Ayôla A., additional, Agnandji, Selidji T., additional, and Ramharter, Michael, additional

Published
2015
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39. Loa loaInfection in Pregnant Women, Gabon

Author

Mombo-Ngoma, Ghyslain, primary, Mackanga, Jean Rodolphe, additional, Basra, Arti, additional, Capan, Meskure, additional, Manego, Rella Zoleko, additional, Adegnika, Ayôla Akim, additional, Lötsch, Felix, additional, Yazdanbakhsh, Maria, additional, González, Raquel, additional, Menendez, Clara, additional, Mabika, Barthelemy, additional, Matsiegui, Pierre Blaise, additional, Kremsner, Peter G., additional, and Ramharter, Michael, additional

Published
2015
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40. Malaria in pregnancy in rural Gabon: a cross-sectional survey on the impact of seasonality in high-risk groups

Author

Jäckle, Mario J, primary, Blumentrath, Christian G, additional, Zoleko, Rella M, additional, Akerey-Diop, Daisy, additional, Mackanga, Jean-Rodolphe, additional, Adegnika, Ayôla A, additional, Lell, Bertrand, additional, Matsiegui, Pierre-Blaise, additional, Kremsner, Peter G, additional, Mombo-Ngoma, Ghyslain, additional, and Ramharter, Michael, additional

Published
2013
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41. Phase I randomized dose-ascending placebo-controlled trials of ferroquine - a candidate anti-malarial drug - in adults with asymptomatic Plasmodium falciparum infection

Author

Mombo-Ngoma, Ghyslain, primary, Supan, Christian, additional, Dal-Bianco, Matthias P, additional, Missinou, Michel A, additional, Matsiegui, Pierre-Blaise, additional, Ospina Salazar, Carmen L, additional, Issifou, Saadou, additional, Ter-Minassian, Daniel, additional, Ramharter, Michael, additional, Kombila, Maryvonne, additional, Kremsner, Peter G, additional, and Lell, Bertrand, additional

Published
2011
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45. Geschichte und Zukunft der Medizinischen Forschung am Albert Schweitzer Spital in Lambaréné, Gabun

Author

Ramharter, Michael, primary, Adegnika, Ayola A., additional, Agnandji, Selidji T., additional, Matsiegui, Pierre Blaise, additional, Grobusch, Martin P., additional, Winkler, Stefan, additional, Graninger, Wolfgang, additional, Krishna, Sanjeev, additional, Yazdanbakhsh, Maria, additional, Mordmüller, Benjamin, additional, Lell, Bertrand, additional, Missinou, Michel A., additional, Mavoungou, Elie, additional, Issifou, Saadou, additional, and Kremsner, Peter G., additional

Published
2007
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46. CD4+CD25hiFOXP3+ Cells in Cord Blood of Neonates Born from Filaria Infected Mother Are Negatively Associated with CD4+Tbet+ and CD4+RORγt+ T Cells.

Author

Ateba-Ngoa, Ulysse, Mombo-Ngoma, Ghyslain, Zettlmeissl, Eva, van der Vlugt, Luciën E. P. M., de Jong, Sanne, Matsiegui, Pierre-Blaise, Ramharter, Michael, Kremsner, Peter G., Yazdanbakhsh, Maria, and Adegnika, Ayola Akim

Subjects
NEWBORN infants, CD4 antigen, CD25 antigen, CORD blood, FILARIASIS, T cells
Abstract

Background: Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers. Moreover children from filaria infected mothers have been shown to be less responsive to vaccination as a consequence of an impairment of their immune response. However, it is not well known how in utero exposure to parasite antigens affects cellular immune responses. Methodology: Here, 30 pregnant women were examined for the presence of microfilaria of Loa loa and Mansonella perstans in peripheral blood. At delivery, cord blood mononuclear cells (CBMC) were obtained and the CD4+T cells were phenotyped by expression of the transcription factors Tbet, RORγt, and FOXP3. Results: No significant difference was observed between newborns from infected versus uninfected mothers in the frequencies of total CD4+T cells and CD4+T cells subsets including CD4+Tbet+, CD4+RORγt+ T and CD4+CD25hiFOXP3+ T cells. However, there was a negative association between CD4+CD25hiFOXP3+T cells and CD4+Tbet+ as well as CD4+RORγt+ T cells in the infected group only (B = −0.242, P = 0.002; B = −0.178, P = 0.013 respectively). Conclusion: Our results suggest that filarial infection during pregnancy leads to an expansion of functionally active regulatory T cells that keep TH1 and TH17 in check. [ABSTRACT FROM AUTHOR]

Published
2014
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47. Fosmidomycin plus Clindamycin for Treatment of Pediatric Patients Aged 1 to 14 Years with Plasmodium falciparum Malaria

Author

Borrmann, Steffen, primary, Lundgren, Ingrid, additional, Oyakhirome, Sunny, additional, Impouma, Bénido, additional, Matsiegui, Pierre-Blaise, additional, Adegnika, Ayola A., additional, Issifou, Saadou, additional, Kun, Jürgen F. J., additional, Hutchinson, David, additional, Wiesner, Jochen, additional, Jomaa, Hassan, additional, and Kremsner, Peter G., additional

Published
2006
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48. Short-Course Regimens of Artesunate-Fosmidomycin in Treatment of Uncomplicated Plasmodium falciparum Malaria

Author

Borrmann, Steffen, primary, Adegnika, Ayola A., additional, Moussavou, Félicien, additional, Oyakhirome, Sunny, additional, Esser, Gilbert, additional, Matsiegui, Pierre-Blaise, additional, Ramharter, Michael, additional, Lundgren, Ingrid, additional, Kombila, Maryvonne, additional, Issifou, Saadou, additional, Hutchinson, David, additional, Wiesner, Jochen, additional, Jomaa, Hassan, additional, and Kremsner, Peter G., additional

Published
2005
Full Text
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