1. Disposable paper-based microfluidics for fertility testing
- Author
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Taşoğlu, Savaş (ORCID 0000-0003-4604-217X & YÖK ID 291971); Sarabi, Misagh Rezapour; Yığcı, Defne; Ata, Barış, Alseed, M. Munzer; Mathyk, Begüm Aydoğan; Halıcıgil, Cihan, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); KU Arçelik Research Center for Creative Industries (KUAR) / KU Arçelik Yaratıcı Endüstriler Uygulama ve Araştırma Merkezi (KUAR); Koç Üniversitesi İş Bankası Yapay Zeka Uygulama ve Araştırma Merkezi (KUIS AI)/ Koç University İş Bank Artificial Intelligence Center (KUIS AI), School of Medicine; College of Engineering; Graduate School of Sciences and Engineering, Department of Mechanical Engineering, Taşoğlu, Savaş (ORCID 0000-0003-4604-217X & YÖK ID 291971); Sarabi, Misagh Rezapour; Yığcı, Defne; Ata, Barış, Alseed, M. Munzer; Mathyk, Begüm Aydoğan; Halıcıgil, Cihan, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); KU Arçelik Research Center for Creative Industries (KUAR) / KU Arçelik Yaratıcı Endüstriler Uygulama ve Araştırma Merkezi (KUAR); Koç Üniversitesi İş Bankası Yapay Zeka Uygulama ve Araştırma Merkezi (KUIS AI)/ Koç University İş Bank Artificial Intelligence Center (KUIS AI), School of Medicine; College of Engineering; Graduate School of Sciences and Engineering, and Department of Mechanical Engineering
- Abstract
Fifteen percent of couples of reproductive age suffer frominfertility globally and the burden of infertility disproportionately impacts residents of developing countries. Assisted reproductive technologies (ARTs), including in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), have been successful in overcoming various reasons for infertility including borderline and severe male factor infertility which consists of 20%-30% of all infertile cases. Approximately half of male infertility cases stem from suboptimal sperm parameters. Therefore, healthy/normal sperm enrichment and sorting remains crucial in advancing reproductive medicine. Microfluidic technologies have emerged as promising tools to develop in- home rapid fertility tests and point-of-care (POC) diagnostic tools. Here, we review advancements in fabrication methods for paper-based-microfluidic devices and their emerging fertility testing applications assessing sperm concentration, sperm motility, sperm DNA analysis, and other sperm functionalities, and provide a glimpse into future directions for paper-based fertility microfluidic systems., Scientific and Technological Research Council of Turkey (TÜBİTAK); 2232 International Fellowship for Outstanding Researchers Award; European Union (EU); Horizon 2020; Marie Sklodowska-Curie Individual Fellowship; Royal Academy Newton-Katip Çelebi Transforming Systems Through Partnership Award; Alexander von Humboldt Research Fellowship for Experienced Researchers; Science Academy Young Scientist Awards Program (BAGEP); Outstanding Young Scientists Awards (GEBİP); Bilim Kahramanlari Dernegi Young Scientist Award
- Published
- 2022