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1,109 results on '"Mathieu, David"'

1. Stereotactic radiosurgery for brain metastases from human epidermal receptor 2 positive breast Cancer: an international, multi-center study.

Author

Pikis, Stylianos, Mantziaris, Georgios, Protopapa, Maria, Tos, Salem, Kowalchuk, Roman, Ross, Richard, Rusthoven, Chad, Tripathi, Manjul, Langlois, Anne-Marie, Mathieu, David, Lee, Cheng-Chia, Yang, Huai-Che, Peker, Selcuk, Samanci, Yavuz, Zhang, Michael, Braunstein, Steve, Wei, Zhishuo, Niranjan, Ajay, Lunsford, Dade, and Sheehan, Jason

Subjects
Brain metastasis, Breast cancer, Gamma Knife, Radiosurgery, Humans, Female, Breast Neoplasms, Radiosurgery, Middle Aged, Brain Neoplasms, Retrospective Studies, Receptor, ErbB-2, Aged, Prognosis, Treatment Outcome, Follow-Up Studies, Adult
Abstract

PURPOSE: To report patient outcomes and local tumor control rates in a cohort of patients with biopsy-proven HER-2 positive breast cancer treated with stereotactic radiosurgery (SRS) for brain metastases (BM). METHODS: This international, retrospective, multicenter study, included 195 female patients with 1706 SRS-treated BM. Radiologic and clinical outcomes after SRS were determined and prognostic factors identified. RESULTS: At SRS, median patient age was 55 years [interquartile range (IQR) 47.6-62.0], and 156 (80%) patients had KPS ≥ 80. The median tumor volume was 0.1 cm3 (IQR 0.1-0.5) and the median prescription dose was 16 Gy (IQR 16-18). Local tumor control (LTC) rate was 98%, 94%, 93%, 90%, and 88% at six-, 12-, 24-, 36- and 60-months post-SRS, respectively. On multivariate analysis, tumor volume (p =

Published
2024

2. Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): an international, multicentric study

Author

Dayawansa, Sam, Dumot, Chloe, Mantziaris, Georgios, Xu, Zhiyuan, Pikis, Stylianos, Peker, Selcuk, Samanci, Yavuz, Ardor, Gokce D., Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Abdelkarim, Khaled, El-Shehaby, Amr M. N., Eldin, Reem M. Emad, Elazzazi, Ahmed H., Moreno, Nuria Martínez, Álvarez, Roberto Martínez, Liscak, Roman, May, Jaromir, Mathieu, David, Tourigny, Jean-Nicolas, Tripathi, Manjul, Rajput, Akshay, Kumar, Narendra, Kaur, Rupinder, Picozzi, Piero, Franzini, Andrea, Speckter, Herwin, Hernandez, Wenceslao, Brito, Anderson, Warnick, Ronald E., Alzate, Juan, Kondziolka, Douglas, Bowden, Greg N., Patel, Samir, and Sheehan, Jason P.

Published
2024
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3. Efficacy and safety of a third stereotactic radiosurgery for recurrent trigeminal neuralgia: an international, multicenter study

Author

De Nigris Vasconcellos, Fernando, Alzate, Juan Diego, Mashiach, Elad, Meng, Ying, Santhumayor, Brandon, Bernstein, Kenneth, Pichardo-Rojas, Pavel, Dono, Antonio, Damron, Ethan P., Blanco, Angel I., Esquenazi, Yoshua, Urgosik, Dusan, May, Jaromir, Lee, Cheng-chia, Yang, Huai-che, Kawalec, Philip, Kaufmann, Anthony M., Mathieu, David, Iorio-Morin, Christian, Picozzi, Piero, Franzini, Andrea, Tripathi, Manjul, Peker, Selcuk, Samanci, Yavuz, Almeida, Timoteo, Benjamin, Carolina, Kondziolka, Douglas, and Sheehan, Jason

Published
2024
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5. Comparison of first-line radiosurgery for small-cell and non-small cell lung cancer brain metastases (CROSS-FIRE).

Author

Rusthoven, Chad, Staley, Alyse, Gao, Dexiang, Yomo, Shoji, Bernhardt, Denise, Wandrey, Narine, El Shafie, Rami, Kraemer, Anna, Padilla, Oscar, Chiang, Veronica, Faramand, Andrew, Palmer, Joshua, Zacharia, Brad, Wegner, Rodney, Hattangadi-Gluth, Jona, Levy, Antonin, Bernstein, Kenneth, Mathieu, David, Cagney, Daniel, Chan, Michael, Grills, Inga, Lee, Cheng-Chia, Sheehan, Jason, Kluwe, Christien, Patel, Samir, Halasz, Lia, Andratschke, Nicolaus, Deibert, Christopher, Verma, Vivek, Trifiletti, Daniel, Cifarelli, Christopher, Debus, Jürgen, Combs, Stephanie, Sato, Yasunori, Higuchi, Yoshinori, Aoyagi, Kyoko, Brown, Paul, Alami, Vida, Niranjan, Ajay, Lunsford, L, Kondziolka, Douglas, Camidge, D, Kavanagh, Brian, Robin, Tyler, Serizawa, Toru, Yamamoto, Masaaki, and Braunstein, Steve

Subjects
Humans, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Retrospective Studies, Radiosurgery, Prospective Studies, Small Cell Lung Carcinoma, ErbB Receptors, Brain Neoplasms
Abstract

INTRODUCTION: Historical reservations regarding stereotactic radiosurgery (SRS) for small-cell lung cancer (SCLC) brain metastases include concerns for short-interval and diffuse central nervous system (CNS) progression, poor prognoses, and increased neurological mortality specific to SCLC histology. We compared SRS outcomes for SCLC and non-small cell lung cancer (NSCLC) where SRS is well established. METHODS: Multicenter first-line SRS outcomes for SCLC and NSCLC from 2000 to 2022 were retrospectively collected (n = 892 SCLC, n = 4785 NSCLC). Data from the prospective Japanese Leksell Gamma Knife Society (JLGK0901) clinical trial of first-line SRS were analyzed as a comparison cohort (n = 98 SCLC, n = 814 NSCLC). Overall survival (OS) and CNS progression were analyzed using Cox proportional hazard and Fine-Gray models, respectively, with multivariable adjustment for cofactors including age, sex, performance status, year, extracranial disease status, and brain metastasis number and volume. Mutation-stratified analyses were performed in propensity score-matched retrospective cohorts of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) positive NSCLC, mutation-negative NSCLC, and SCLC. RESULTS: OS was superior for patients with NSCLC compared to SCLC in the retrospective dataset (median OS = 10.5 vs 8.6 months; P

Published
2023

6. Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma

Author

Liau, Linda M, Ashkan, Keyoumars, Brem, Steven, Campian, Jian L, Trusheim, John E, Iwamoto, Fabio M, Tran, David D, Ansstas, George, Cobbs, Charles S, Heth, Jason A, Salacz, Michael E, D’Andre, Stacy, Aiken, Robert D, Moshel, Yaron A, Nam, Joo Y, Pillainayagam, Clement P, Wagner, Stephanie A, Walter, Kevin A, Chaudhary, Rekha, Goldlust, Samuel A, Lee, Ian Y, Bota, Daniela A, Elinzano, Heinrich, Grewal, Jai, Lillehei, Kevin, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven, Brenner, Andrew J, Ewend, Matthew G, Khagi, Simon, Lovick, Darren S, Portnow, Jana, Kim, Lyndon, Loudon, William G, Martinez, Nina L, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Giglio, Pierre, Gligich, Oleg, Krex, Dietmar, Lindhorst, Scott M, Lutzky, Jose, Meisel, Hans-Jörg, Nadji-Ohl, Minou, Sanchin, Lhagva, Sloan, Andrew, Taylor, Lynne P, Wu, Julian K, Dunbar, Erin M, Etame, Arnold B, Kesari, Santosh, Mathieu, David, Piccioni, David E, Baskin, David S, Lacroix, Michel, May, Sven-Axel, New, Pamela Z, Pluard, Timothy J, Toms, Steven A, Tse, Victor, Peak, Scott, Villano, John L, Battiste, James D, Mulholland, Paul J, Pearlman, Michael L, Petrecca, Kevin, Schulder, Michael, Prins, Robert M, Boynton, Alton L, and Bosch, Marnix L

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prevention, Brain Disorders, Brain Cancer, Cancer, Clinical Trials and Supportive Activities, Clinical Research, Rare Diseases, Neurosciences, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Humans, Glioblastoma, Temozolomide, Prospective Studies, Brain Neoplasms, Recurrence, Dendritic Cells, Vaccination, Public Health and Health Services, Oncology and carcinogenesis
Abstract

ImportanceGlioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.ObjectiveTo investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.Design, setting, and participantsThis phase 3, prospective, externally controlled nonrandomized trial compared overall survival (OS) in patients with newly diagnosed glioblastoma (nGBM) and recurrent glioblastoma (rGBM) treated with DCVax-L plus SOC vs contemporaneous matched external control patients treated with SOC. This international, multicenter trial was conducted at 94 sites in 4 countries from August 2007 to November 2015. Data analysis was conducted from October 2020 to September 2021.InterventionsThe active treatment was DCVax-L plus SOC temozolomide. The nGBM external control patients received SOC temozolomide and placebo; the rGBM external controls received approved rGBM therapies.Main outcomes and measuresThe primary and secondary end points compared overall survival (OS) in nGBM and rGBM, respectively, with contemporaneous matched external control populations from the control groups of other formal randomized clinical trials.ResultsA total of 331 patients were enrolled in the trial, with 232 randomized to the DCVax-L group and 99 to the placebo group. Median OS (mOS) for the 232 patients with nGBM receiving DCVax-L was 19.3 (95% CI, 17.5-21.3) months from randomization (22.4 months from surgery) vs 16.5 (95% CI, 16.0-17.5) months from randomization in control patients (HR = 0.80; 98% CI, 0.00-0.94; P = .002). Survival at 48 months from randomization was 15.7% vs 9.9%, and at 60 months, it was 13.0% vs 5.7%. For 64 patients with rGBM receiving DCVax-L, mOS was 13.2 (95% CI, 9.7-16.8) months from relapse vs 7.8 (95% CI, 7.2-8.2) months among control patients (HR, 0.58; 98% CI, 0.00-0.76; P

Published
2023

7. Comparative analysis of stereotactic radiosurgery outcomes for supratentorial hemangioblastomas in von hippel-lindau disease and sporadic cases: A multi-center international study

Author

Tos, Salem M., Hajikarimloo, Bardia, Mantziaris, Georgios, Shaaban, Ahmed, Pham, Duy, Dayawansa, Sam, Wei, Zhishuo, McKendrick, Lindsay M., Niranjan, Ajay, Lunsford, L Dade, Peker, Selcuk, Samanci, Yavuz, Liscak, Roman, May, Jaromir, Mathieu, David, Picozzi, Piero, Franzini, Andrea, Warnick, Ronald E., Schoenhals, Jonathan E., Palmer, Joshua D., Xu, Zhiyuan, and Sheehan, Jason P.

Published
2024
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8. Vestibular Schwannoma International Study of Active Surveillance Versus Stereotactic Radiosurgery: The VISAS Study

Author

Bin-Alamer, Othman, Abou-Al-Shaar, Hussam, Peker, Selcuk, Samanci, Yavuz, Pelcher, Isabelle, Begley, Sabrina, Goenka, Anuj, Schulder, Michael, Tourigny, Jean-Nicolas, Mathieu, David, Hamel, Andréanne, Briggs, Robert G, Yu, Cheng, Zada, Gabriel, Giannotta, Steven L, Speckter, Herwin, Palque, Sarai, Tripathi, Manjul, Kumar, Saurabh, Kaur, Rupinder, Kumar, Narendra, Rogowski, Brandon, Shepard, Matthew J., Johnson, Bryan A., Trifiletti, Daniel M., Warnick, Ronald E., Dayawansa, Samantha, Mashiach, Elad, Vasconcellos, Fernando De Nigris, Bernstein, Kenneth, Schnurman, Zane, Alzate, Juan, Kondziolka, Douglas, and Sheehan, Jason P.

Published
2024
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9. Immune checkpoint inhibition and single fraction stereotactic radiosurgery in brain metastases from non-small cell lung cancer: an international multicenter study of 395 patients

Author

Lehrer, Eric J., Khosla, Atulya A., Ozair, Ahmad, Gurewitz, Jason, Bernstein, Kenneth, Kondziolka, Douglas, Niranjan, Ajay, Wei, Zhishuo, Lunsford, L. Dade, Mathieu, David, Trudel, Claire, Deibert, Christopher P., Malouff, Timothy D., Ruiz-Garcia, Henry, Peterson, Jennifer L., Patel, Samir, Bonney, Phillip, Hwang, Lindsay, Yu, Cheng, Zada, Gabriel, Picozzi, Piero, Franzini, Andrea, Attuati, Luca, Prasad, Rahul N., Raval, Raju R., Palmer, Joshua D., Lee, Cheng-chia, Yang, Huai-che, Fakhoury, Kareem R., Rusthoven, Chad G., Dickstein, Daniel R., Sheehan, Jason P., Trifiletti, Daniel M., and Ahluwalia, Manmeet S.

Published
2023
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10. Epilepsy associated with cerebral cavernous malformations managed with stereotactic radiosurgery: an international, multicenter study

Author

Dumot, Chloe, Mantziaris, Georgios, Pikis, Stylianos, Dayawansa, Sam, Xu, Zhiyuan, Samanci, Yavuz, Ardor, Gokce D., Peker, Selcuk, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Abdel Karim, Khaled, El-Shehaby, Amr M. N., Eldin, Reem M. Emad, Elazzazi, Ahmed H., Moreno, Nuria Martínez, Álvarez, Roberto Martínez, Liscak, Roman, May, Jaromir, Mathieu, David, Tourigny, Jean-Nicolas, Tripathi, Manjul, Rajput, Akshay, Kumar, Narendra, Kaur, Rupinder, Picozzi, Piero, Franzini, Andrea, Speckter, Herwin, Hernandez, Wenceslao, Brito, Anderson, Warnick, Ronald E., Alzate, Juan, Kondziolka, Douglas, Bowden, Greg N., Patel, Samir, and Sheehan, Jason P.

Published
2023
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12. Pain Disorders

Author

Iorio-Morin, Christian, Villeneuve, Samuelle-Arianne, Masson-Côté, Laurence, Mathieu, David, Roberge, David, editor, and Donaldson, Sarah S., editor

Published
2023
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13. Neurological Disorders

Author

Iorio-Morin, Christian, Villeneuve, Samuelle-Arianne, Masson-Côté, Laurence, Mathieu, David, Roberge, David, editor, and Donaldson, Sarah S., editor

Published
2023
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18. Introduction

Author

Hartley, Jannie Møller, primary, Mathieu, David, additional, and Sørensen, Jannick Kirk, additional

Published
2023
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19. A new open, high-resolution, multishell, diffusion-weighted imaging dataset of the living squirrel monkey

Author

Thomas Orset, Julie Royo, Mathieu David Santin, Pierre Pouget, and Michel Thiebaut de Schotten

Subjects
Science
Abstract

Abstract Although very well adapted to brain study, Magnetic Resonance Imaging (MRI) remains limited by the facilities and capabilities required to acquire data, especially for non-human primates. Addressing the data gaps resulting from these limitations requires making data more accessible and open. In contempt of the regular use of Saimiri sciureus in neuroscience research, in vivo diffusion has yet to be openly available for this species. Here we built and made openly available a unique new resource consisting of a high-resolution, multishell diffusion-weighted dataset in the anesthetized Saimiri sciureus. The data were acquired on 11 individuals with an 11.7 T MRI scanner (isotropic resolution of 400 µm3). This paper presents an overview of our dataset and illustrates some of its possible use through example analyses. To assess the quality of our data, we analyzed long-range connections (whole-brain tractography), microstructure (Neurite Orientation Dispersion and Density Imaging), and axon diameter in the corpus callosum (ActiveAx). Constituting an essential new resource for primate evolution studies, all data are openly available.

Published
2023
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20. Stereotactic radiosurgery for Koos grade IV vestibular schwannoma in patients ≥ 65 years old: a multi-institutional retrospective study

Author

Dumot, Chloe, Pikis, Stylianos, Mantziaris, Georgios, Xu, Zhiyuan, Dayawansa, Sam, Anand, Rithika Kormath, Nabeel, Ahmed M., Sheehan, Darrah, Sheehan, Kimball, Reda, Wael A., Tawadros, Sameh R., Karim, Khaled Abdel, El-Shehaby, Amr M. N., Eldin, Reem M. Emad, Peker, Selcuk, Samanci, Yavuz, Kaisman-Elbaz, Tehila, Speckter, Herwin, Hernández, Wenceslao, Isidor, Julio, Tripathi, Manjul, Madan, Renu, Zacharia, Brad E., Daggubati, Lekhaj C., Moreno, Nuria Martínez, Álvarez, Roberto Martínez, Langlois, Anne-Marie, Mathieu, David, Deibert, Christopher P., Sudhakar, Vivek R., Cifarelli, Christopher P., Icaza, Denisse Arteaga, Cifarelli, Daniel T., Wei, Zhishuo, Niranjan, Ajay, Barnett, Gene H., Lunsford, L. Dade, Bowden, Greg N., and Sheehan, Jason P.

Published
2023
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21. Stereotactic radiosurgery for Koos grade IV vestibular schwannoma in young patients: a multi-institutional study

Author

Dumot, Chloe, Pikis, Stylianos, Mantziaris, Georgios, Xu, Zhiyuan, Anand, Rithika Kormath, Nabeel, Ahmed M., Sheehan, Darrah, Sheehan, Kimball, Reda, Wael A., Tawadros, Sameh R., Abdel Karim, Khaled, El-Shehaby, Amr M. N., Emad Eldin, Reem M., Peker, Selcuk, Samanci, Yavuz, Kaisman-Elbaz, Tehila, Speckter, Herwin, Hernández, Wenceslao, Isidor, Julio, Tripathi, Manjul, Madan, Renu, Zacharia, Brad E., Daggubati, Lekhaj C., Moreno, Nuria Martínez, Álvarez, Roberto Martínez, Langlois, Anne-Marie, Mathieu, David, Deibert, Christopher P., Sudhakar, Vivek R., Cifarelli, Christopher P., Icaza, Denisse Arteaga, Cifarelli, Daniel T., Wei, Zhishuo, Niranjan, Ajay, Barnett, Gene H., Lunsford, L. Dade, Bowden, Greg N., and Sheehan, Jason P.

Published
2022
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22. Pain Disorders

Author

Iorio-Morin, Christian, primary, Villeneuve, Samuelle-Arianne, additional, Masson-Côté, Laurence, additional, and Mathieu, David, additional

Published
2023
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23. Neurological Disorders

Author

Iorio-Morin, Christian, primary, Villeneuve, Samuelle-Arianne, additional, Masson-Côté, Laurence, additional, and Mathieu, David, additional

Published
2023
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25. Concurrent Administration of Immune Checkpoint Inhibitors and Single Fraction Stereotactic Radiosurgery in Patients With Non-Small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma Brain Metastases is Not Associated With an Increased Risk of Radiation Necrosis Over Nonconcurrent Treatment: An International Multicenter Study of 657 Patients

Author

Lehrer, Eric J., Kowalchuk, Roman O., Gurewitz, Jason, Bernstein, Kenneth, Kondziolka, Douglas, Niranjan, Ajay, Wei, Zhishuo, Lunsford, L. Dade, Fakhoury, Kareem R., Rusthoven, Chad G., Mathieu, David, Trudel, Claire, Malouff, Timothy D., Ruiz-Garcia, Henry, Bonney, Phillip, Hwang, Lindsay, Yu, Cheng, Zada, Gabriel, Patel, Samir, Deibert, Christopher P., Picozzi, Piero, Franzini, Andrea, Attuati, Luca, Prasad, Rahul N., Raval, Raju R., Palmer, Joshua D., Lee, Cheng-chia, Yang, Huai-che, Harmsen, William S., Jones, Brianna M., Sharma, Sonam, Ahluwalia, Manmeet S., Sheehan, Jason P., and Trifiletti, Daniel M.

Published
2023
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26. Solar Forecasts Based on the Clear Sky Index or the Clearness Index: Which Is Better?

Author

Philippe Lauret, Rodrigo Alonso-Suárez, Josselin Le Gal La Salle, and Mathieu David

Subjects
solar irradiance forecasts, clear sky index, clearness index, extraterrestrial irradiance, clear sky model, Production of electric energy or power. Powerplants. Central stations, TK1001-1841
Abstract

In the realm of solar forecasting, it is common to use a clear sky model output to deseasonalise the solar irradiance time series needed to build the forecasting models. However, most of these clear sky models require the setting of atmospheric parameters for which accurate values may not be available for the site under study. This can hamper the accuracy of the prediction models. Normalisation of the irradiance data with a clear sky model leads to the construction of forecasting models with the so-called clear sky index. Another way to normalize the irradiance data is to rely on the extraterrestrial irradiance, which is the irradiance at the top of the atmosphere. Extraterrestrial irradiance is defined by a simple equation that is related to the geometric course of the sun. Normalisation with the extraterrestrial irradiance leads to the building of models with the clearness index. In the solar forecasting domain, most models are built using time series based on the clear sky index. However, there is no empirical evidence thus far that the clear sky index approach outperforms the clearness index approach. Therefore the goal of this preliminary study is to evaluate and compare the two approaches. The numerical experimental setup for evaluating the two approaches is based on three forecasting methods, namely, a simple persistence model, a linear AutoRegressive (AR) model, and a non-linear neural network (NN) model, all of which are applied at six sites with different sky conditions. It is shown that normalization of the solar irradiance with the help of a clear sky model produces better forecasts irrespective of the type of model used. However, it is demonstrated that a nonlinear forecasting technique such as a neural network built with clearness time series can beat simple linear models constructed with the clear sky index.

Published
2022
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27. Stereotactic Radiosurgery for Brain Metastases from Human Epidermal Receptor 2 Positive Breast Cancer: An International, Multi-center Study

Author

Pikis, Stylianos, primary, Mantziaris, Georgios, additional, Protopapa, Maria, additional, Kowalchuk, Roman O. Kowalchuk, additional, Ross, Richard Blake, additional, Rusthoven, Chad G., additional, Tripathi, Manjul, additional, Langlois, Anne-Marie Langlois, additional, Mathieu, David, additional, Lee, Cheng-chia Lee, additional, Yang, Huai-che, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Zhang, Michael Yu, additional, Braunstein, Steve E., additional, Toss, Salem M., additional, Niranjan, Ajay, additional, Wei, Zhishuo, additional, Lunsford, Dade, additional, and Sheehan, Jason, additional

Published
2024
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29. First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Author

Liau, Linda M, Ashkan, Keyoumars, Tran, David D, Campian, Jian L, Trusheim, John E, Cobbs, Charles S, Heth, Jason A, Salacz, Michael, Taylor, Sarah, D’Andre, Stacy D, Iwamoto, Fabio M, Dropcho, Edward J, Moshel, Yaron A, Walter, Kevin A, Pillainayagam, Clement P, Aiken, Robert, Chaudhary, Rekha, Goldlust, Samuel A, Bota, Daniela A, Duic, Paul, Grewal, Jai, Elinzano, Heinrich, Toms, Steven A, Lillehei, Kevin O, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven R, Brenner, Andrew J, Brem, Steven, Ewend, Matthew G, Khagi, Simon, Portnow, Jana, Kim, Lyndon J, Loudon, William G, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Lindhorst, Scott, Lutzky, Jose, Sloan, Andrew E, Schackert, Gabriele, Krex, Dietmar, Meisel, Hans-Jorg, Wu, Julian, Davis, Raphael P, Duma, Christopher, Etame, Arnold B, Mathieu, David, Kesari, Santosh, Piccioni, David, Westphal, Manfred, Baskin, David S, New, Pamela Z, Lacroix, Michel, May, Sven-Axel, Pluard, Timothy J, Tse, Victor, Green, Richard M, Villano, John L, Pearlman, Michael, Petrecca, Kevin, Schulder, Michael, Taylor, Lynne P, Maida, Anthony E, Prins, Robert M, Cloughesy, Timothy F, Mulholland, Paul, and Bosch, Marnix L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Brain Cancer, Neurosciences, Immunization, Clinical Research, Cancer, Brain Disorders, Rare Diseases, Patient Safety, Prevention, Vaccine Related, Orphan Drug, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, Brain Neoplasms, Cancer Vaccines, Dendritic Cells, Endpoint Determination, Female, Glioblastoma, Humans, Male, Middle Aged, Prognosis, Survival Analysis, Treatment Outcome, Young Adult, Immunotherapy, Dendritic cell, Vaccine, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundStandard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard therapy for newly diagnosed glioblastoma.MethodsAfter surgery and chemoradiotherapy, patients were randomized (2:1) to receive temozolomide plus DCVax-L (n = 232) or temozolomide and placebo (n = 99). Following recurrence, all patients were allowed to receive DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); the secondary endpoint was overall survival (OS).ResultsFor the intent-to-treat (ITT) population (n = 331), median OS (mOS) was 23.1 months from surgery. Because of the cross-over trial design, nearly 90% of the ITT population received DCVax-L. For patients with methylated MGMT (n = 131), mOS was 34.7 months from surgery, with a 3-year survival of 46.4%. As of this analysis, 223 patients are ≥ 30 months past their surgery date; 67 of these (30.0%) have lived ≥ 30 months and have a Kaplan-Meier (KM)-derived mOS of 46.5 months. 182 patients are ≥ 36 months past surgery; 44 of these (24.2%) have lived ≥ 36 months and have a KM-derived mOS of 88.2 months. A population of extended survivors (n = 100) with mOS of 40.5 months, not explained by known prognostic factors, will be analyzed further. Only 2.1% of ITT patients (n = 7) had a grade 3 or 4 adverse event that was deemed at least possibly related to the vaccine. Overall adverse events with DCVax were comparable to standard therapy alone.ConclusionsAddition of DCVax-L to standard therapy is feasible and safe in glioblastoma patients, and may extend survival. Trial registration Funded by Northwest Biotherapeutics; Clinicaltrials.gov number: NCT00045968; https://clinicaltrials.gov/ct2/show/NCT00045968?term=NCT00045968&rank=1 ; initially registered 19 September 2002.

Published
2018

30. Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Author

Liau, Linda M, Ashkan, Keyoumars, Tran, David D, Campian, Jian L, Trusheim, John E, Cobbs, Charles S, Heth, Jason A, Salacz, Michael, Taylor, Sarah, D’Andre, Stacy D, Iwamoto, Fabio M, Dropcho, Edward J, Moshel, Yaron A, Walter, Kevin A, Pillainayagam, Clement P, Aiken, Robert, Chaudhary, Rekha, Goldlust, Samuel A, Bota, Daniela A, Duic, Paul, Grewal, Jai, Elinzano, Heinrich, Toms, Steven A, Lillehei, Kevin O, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven R, Brenner, Andrew J, Brem, Steven, Ewend, Matthew G, Khagi, Simon, Portnow, Jana, Kim, Lyndon J, Loudon, William G, Thompson, Reid C, Avigan, David E, Fink, Karen L, Geoffroy, Francois J, Lindhorst, Scott, Lutzky, Jose, Sloan, Andrew E, Schackert, Gabriele, Krex, Dietmar, Meisel, Hans-Jorg, Wu, Julian, Davis, Raphael P, Duma, Christopher, Etame, Arnold B, Mathieu, David, Kesari, Santosh, Piccioni, David, Westphal, Manfred, Baskin, David S, New, Pamela Z, Lacroix, Michel, May, Sven-Axel, Pluard, Timothy J, Tse, Victor, Green, Richard M, Villano, John L, Pearlman, Michael, Petrecca, Kevin, Schulder, Michael, Taylor, Lynne P, Maida, Anthony E, Prins, Robert M, Cloughesy, Timothy F, Mulholland, Paul, and Bosch, Marnix L

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Neurosciences, Brain Disorders, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

Following publication of the original article [1], the authors reported an error in the spelling of one of the author names. In this Correction the incorrect and correct author names are indicated and the author name has been updated in the original publication. The authors also reported an error in the Methods section of the original article. In this Correction the incorrect and correct versions of the affected sentence are indicated. The original article has not been updated with regards to the error in the Methods section.

Published
2018

31. Outcome Evaluation of Repeat Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations

Author

Mantziaris, Georgios, Pikis, Stylianos, Dumot, Chloe, Dayawansa, Samantha, Liščák, Roman, May, Jaromir, Lee, Cheng-chia, Yang, Huai-che, Martinez Moreno, Nuria, Martinez Álvarez, Roberto, Lunsford, L. Dade, Niranjan, Ajay, Wei, Zhishuo, Srinivasan, Priyanka, Tang, Lilly W., Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Abdelkarim, Khaled, El-Shehaby, Amr M.N., Emad, Reem M., Hesham Elazzazi, Ahmed, Peker, Selcuk, Samanci, Yavuz, Padmanaban, Varun, Jareczek, Francis J., McInerney, James, Cockroft, Kevin M., Mathieu, David, Aldakhil, Salman, Alzate, Juan Diego, Kondziolka, Douglas, Tripathi, Manjul, Palmer, Joshua D., Upadhyay, Rituraj, Lin, Michelle, Zada, Gabriel, Yu, Cheng, Cifarelli, Christopher P., Cifarelli, Daniel T., Xu, Zhiyuan, and Sheehan, Jason P.

Published
2023
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32. Stereotactic radiosurgery versus active surveillance for incidental, convexity meningiomas: a matched cohort analysis from the IMPASSE study

Author

Pikis, Stylianos, Mantziaris, Georgios, Islim, Abdurrahman I., Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Abdelkarim, Khaled, El-Shehaby, Amr M. N., Tawadros, Sameh R., Emad, Reem M., Delabar, Violaine, Mathieu, David, Lee, Cheng-chia, Yang, Huai-che, Licsak, Roman, Hanuska, Jaromir, Alvarez, Roberto Martinez, Patel, Dev N., Kondziolka, Douglas, Bernstein, Kenneth, Moreno, Nuria Martinez, Tripathi, Manjul, Speckter, Herwin, Albert, Camilo, Bowden, Greg N., Benveniste, Ronald J., Lunsford, Dade L., Jenkinson, Michael D., and Sheehan, Jason

Published
2022
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33. Reirradiation With Stereotactic Radiosurgery After Local or Marginal Recurrence of Brain Metastases From Previous Radiosurgery

Author

Kowalchuk, Roman O., Niranjan, Ajay, Lee, Cheng-chia, Yang, Huai-che, Liscak, Roman, Guseynova, Khumar, Tripathi, Manjul, Kumar, Narendra, Peker, Selcuk, Samanci, Yavuz, Hess, Judith, Chiang, Veronica, Iorio-Morin, Christian, Mathieu, David, Pikis, Stylianos, Wei, Zhishuo, Lunsford, L. Dade, Trifiletti, Daniel M., and Sheehan, Jason P.

Published
2022
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36. Comparison of Repeat Versus Initial Stereotactic Radiosurgery for Intracranial Arteriovenous Malformations: A Retrospective Multicenter Matched Cohort Study.

Author

Orrego Gonzalez, Eduardo, Mantziaris, Georgios, Shaaban, Ahmed, Starke, Robert M., Ding, Dale, Lee, John Y. K., Mathieu, David, Kondziolka, Douglas, Feliciano, Caleb, Grills, Inga S., Barnett, Gene H., Lunsford, L. Dade, Liščák, Roman, Cheng-chia Lee, Álvarez, Roberto Martinez, Peker, Selcuk, Samanci, Yavuz, Cockroft, Kevin M., Tripathi, Manjul, and Palmer, Joshua D.

Published
2024
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37. Probabilistic Solar Forecasts as a Binary Event Using a Sky Camera

Author

Mathieu David, Joaquín Alonso-Montesinos, Josselin Le Gal La Salle, and Philippe Lauret

Subjects
solar energy, concentrated solar plant (CSP), binary probabilistic forecasts, all sky imager (ASI), photovoltaic (PV), Brier Score, Technology
Abstract

With the fast increase of solar energy plants, a high-quality short-term forecast is required to smoothly integrate their production in the electricity grids. Usually, forecasting systems predict the future solar energy as a continuous variable. But for particular applications, such as concentrated solar plants with tracking devices, the operator needs to anticipate the achievement of a solar irradiance threshold to start or stop their system. In this case, binary forecasts are more relevant. Moreover, while most forecasting systems are deterministic, the probabilistic approach provides additional information about their inherent uncertainty that is essential for decision-making. The objective of this work is to propose a methodology to generate probabilistic solar forecasts as a binary event for very short-term horizons between 1 and 30 min. Among the various techniques developed to predict the solar potential for the next few minutes, sky imagery is one of the most promising. Therefore, we propose in this work to combine a state-of-the-art model based on a sky camera and a discrete choice model to predict the probability of an irradiance threshold suitable for plant operators. Two well-known parametric discrete choice models, logit and probit models, and a machine learning technique, random forest, were tested to post-process the deterministic forecast derived from sky images. All three models significantly improve the quality of the original deterministic forecast. However, random forest gives the best results and especially provides reliable probability predictions.

Published
2023
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38. Stereotactic radiosurgery versus active surveillance for asymptomatic, skull-based meningiomas: an international, multicenter matched cohort study

Author

Mantziaris, Georgios, Pikis, Stylianos, Samanci, Yavuz, Peker, Selcuk, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., El-Shehaby, Amr M. N., Abdelkarim, Khaled, Emad, Reem M., Delabar, Violaine, Mathieu, David, Lee, Cheng-chia, Yang, Huai-che, Liscak, Roman, Hanuska, Jaromir, Alvarez, Roberto Martinez, Moreno, Nuria Martinez, Tripathi, Manjul, Speckter, Herwin, Albert, Camilo, Benveniste, Ronald J., Bowden, Greg N., Patel, Dev N., Kondziolka, Douglas, Bernstein, Kenneth, Lunsford, L. Dade, Jenkinson, Michael D., Islim, Abdurrahman I., and Sheehan, Jason

Published
2022
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39. Stereotactic radiosurgery for asymptomatic petroclival region meningiomas: a focused analysis from the IMPASSE study

Author

Mantziaris, Georgios, Pikis, Stylianos, Bunevicius, Adomas, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., El-Shehaby, Amr M. N., Abdelkarim, Khaled, Emad, Reem M., Delabar, Violaine, Mathieu, David, Lee, Cheng-chia, Yang, Huai-che, Liscak, Roman, Hanuska, Jaromir, Alvarez, Roberto Martinez, Moreno, Nuria Martinez, Tripathi, Manjul, Speckter, Herwin, Albert, Camilo, Bowden, Greg N., Benveniste, Ronald J., Patel, Dev N., Kondziolka, Douglas, Bernstein, Kenneth, Lunsford, L. Dade, and Sheehan, Jason

Published
2022
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40. Stereotactic radiosurgery for IDH wild type glioblastoma: an international, multicenter study

Author

Bunevicius, Adomas, Pikis, Stylianos, Kondziolka, Douglas, Patel, Dev N., Bernstein, Kenneth, Sulman, Erik P., Lee, Cheng-chia, Yang, Huai-che, Delabar, Violaine, Mathieu, David, Cifarelli, Christopher P., Arsanious, David E., Dahshan, Basem A., Weir, Joshua S., Speckter, Herwin, Mota, Angel, Tripathi, Manjul, Kumar, Narendra, Warnick, Ronald E., Peker, Selcuk, Samanci, Yavuz, Barnett, Gene, Hefnawi, Farid El, Al Sideiri, Ghusn, and Sheehan, Jason

Published
2021
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41. Hypopituitarism after Gamma Knife radiosurgery for pituitary adenomas: a multicenter, international study

Author

Cordeiro, Diogo, Xu, Zhiyuan, Mehta, Gautam, Ding, Dale, Vance, Mary Lee, Kano, Hideyuki, Sisterson, Nathaniel, Yang, Huai-che, Kondziolka, Douglas, Lunsford, L Dade, Mathieu, David, Barnett, Gene, Chiang, Veronica, Lee, John, Sneed, Penny, Su, Yan-Hua, Lee, Cheng-chia, Krsek, Michal, Liscak, Roman, Nabeel, Ahmed, El-Shehaby, Amr, Karim, Khaled, Reda, Wael, Martinez-Moreno, Nuria, Martinez-Alvarez, Roberto, Blas, Kevin, Grills, Inga, Lee, Kuei, Kosak, Mikulas, Cifarelli, Christopher, Katsevman, Gennadiy, and Sheehan, Jason

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Rare Diseases, hypopituitarism, pituitary adenoma, Cushing's disease, acromegaly, stereotactic radiosurgery, Cushing’s disease, Neurosciences, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveRecurrent or residual adenomas are frequently treated with Gamma Knife radiosurgery (GKRS). The most common complication after GKRS for pituitary adenomas is hypopituitarism. In the current study, the authors detail the timing and types of hypopituitarism in a multicenter, international cohort of pituitary adenoma patients treated with GKRS.MethodsSeventeen institutions pooled clinical data obtained from pituitary adenoma patients who were treated with GKRS from 1988 to 2016. Patients who had undergone prior radiotherapy were excluded. A total of 1023 patients met the study inclusion criteria. The treated lesions included 410 nonfunctioning pituitary adenomas (NFPAs), 262 cases of Cushing’s disease (CD), and 251 cases of acromegaly. The median follow-up was 51 months (range 6–246 months). Statistical analysis was performed using a Cox proportional hazards model to evaluate factors associated with the development of new-onset hypopituitarism.ResultsAt last follow-up, 248 patients had developed new pituitary hormone deficiency (86 with NFPA, 66 with CD, and 96 with acromegaly). Among these patients, 150 (60.5%) had single and 98 (39.5%) had multiple hormone deficiencies. New hormonal changes included 82 cortisol (21.6%), 135 thyrotropin (35.6%), 92 gonadotropin (24.3%), 59 growth hormone (15.6%), and 11 vasopressin (2.9%) deficiencies. The actuarial 1-year, 3-year, 5-year, 7-year, and 10-year rates of hypopituitarism were 7.8%, 16.2%, 22.4%, 27.5%, and 31.3%, respectively. The median time to hypopituitarism onset was 39 months.In univariate analyses, an increased rate of new-onset hypopituitarism was significantly associated with a lower isodose line (p = 0.006, HR = 8.695), whole sellar targeting (p = 0.033, HR = 1.452), and treatment of a functional pituitary adenoma as compared with an NFPA (p = 0.008, HR = 1.510). In multivariate analyses, only a lower isodose line was found to be an independent predictor of new-onset hypopituitarism (p = 0.001, HR = 1.38).ConclusionsHypopituitarism remains the most common unintended effect of GKRS for a pituitary adenoma. Treating the target volume at an isodose line of 50% or greater and avoiding whole-sellar radiosurgery, unless necessary, will likely mitigate the risk of post-GKRS hypopituitarism. Follow-up of these patients is required to detect and treat latent endocrinopathies.

Published
2018

43. Local control and survival after stereotactic radiosurgery for colorectal cancer brain metastases: an international multicenter analysis

Author

Bin-Alamer, Othman, primary, Abou-Al-Shaar, Hussam, additional, Singh, Raj, additional, Mallela, Arka N., additional, Legarreta, Andrew, additional, Bowden, Greg, additional, Mathieu, David, additional, Perlow, Haley K., additional, Palmer, Joshua D., additional, Elhamdani, Shahed, additional, Shepard, Matthew, additional, Liang, Yun, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad Eldin, Reem, additional, Elazzazi, Ahmed Hesham, additional, Warnick, Ronald E., additional, Gozal, Yair M., additional, Daly, Megan, additional, McShane, Brendan, additional, Addis-Jackson, Marcel, additional, Karthikeyan, Gokul, additional, Smith, Sian, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Kaisman-Elbaz, Tehila, additional, Yang, Huai-che, additional, Hess, Judith, additional, Templeton, Kelsey, additional, Zhang, Xiaoran, additional, Wei, Zhishuo, additional, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Simonova, Gabriela, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Chiang, Veronica, additional, Kersh, Charles R., additional, Lee, Cheng-Chia, additional, Trifiletti, Daniel M., additional, Niranjan, Ajay, additional, Hadjipanayis, Constantinos G., additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2024
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44. Stereotactic Radiosurgery for WHO Grade 2 and 3 Oligodendroglioma: An International Multicenter Study

Author

Langlois, Anne-Marie, primary, Iorio-Morin, Christian, additional, Kallos, Justiss, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Park, David J., additional, Barnett, Gene H., additional, Liscak, Roman, additional, Simonova, Gabriela, additional, Sheehan, Jason P., additional, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Lee, Cheng-Chia, additional, Yang, Huai-Che, additional, Bowden, Gregory N., additional, and Mathieu, David, additional

Published
2024
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45. 177 So the Bone Flap Hit the Floor, Now What?

Author

Marion, Alexis, primary, Lévesque, Simon, additional, Touchette, Charles, additional, Villeneuve, Samuelle-Arianne, additional, Huppé-Gignac, Béatrice, additional, Mathieu, David, additional, Martin, Philippe, additional, Arsenault, Christine, additional, and Lorio-Morin, Christian, additional

Published
2024
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46. 499 Silent Corticotroph Staining Pituitary Neuroendocrine Tumors: Prognostic Significance in Radiosurgery

Author

Maragkos, Georgios A., primary, Mantziaris, Georgios, additional, Pikis, Stylianos, additional, Chytka, Tomas, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Bindal, Shray, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Kaur, Rupinder, additional, Tripathi, Manjul, additional, Pangal, Dhiraj J., additional, Strickland, Ben Allen, additional, Zada, Gabriel, additional, Langlois, Anne-Marie, additional, Mathieu, David, additional, Warnick, Ronald E., additional, Patel, Samir, additional, Minier, Zayda, additional, Speckter, Herwin, additional, Kondziolka, Douglas S., additional, Lee, Cheng-chia, additional, Lee Vance, Mary, additional, and Sheehan, Jason P., additional

Published
2024
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47. 220 Outcome Evaluation of Repeat Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations

Author

Mantziaris, Georgios, primary, Dumot, Chloe, additional, Liscak, Roman, additional, Lee, Cheng-Chia, additional, Lunsford, L. Dade, additional, Niranjan, Ajay, additional, Peker, Selcuk, additional, Mathieu, David, additional, Kondziolka, Douglas S., additional, Tripathi, Manjul, additional, Palmer, Joshua, additional, Zada, Gabriel, additional, Cifarelli, Christopher Paul, additional, Pikis, Stylianos, additional, Dayawansa, Sam, additional, and Sheehan, Jason P., additional

Published
2024
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48. Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): An International, Multicentric Study

Author

Dayawansa, Sam, primary, Dumot, Chloe, additional, Mantziaris, Georgios, additional, Xu, Zhiyuan, additional, Pikis, Stylianos, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Ardor, Gokce D, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M. N., additional, Eldin, Reem M Emad, additional, Elazzazi, Ahmed H, additional, Moreno, Nuria Martínez, additional, Álvarez, Roberto Martínez, additional, Liscak, Roman, additional, May, Jaromir, additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Rajput, Akshay, additional, Kumar, Narendra, additional, Kaur, Rupinder, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Brito, Anderson, additional, Warnick, Ronald E., additional, Alzate, Juan, additional, Kondziolka, Douglas, additional, Bowden, Greg N., additional, Patel, Samir, additional, and sheehan, jason, additional

Published
2024
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49. Long-term radiographic and endocrinological outcomes of stereotactic radiosurgery for recurrent or residual nonfunctioning pituitary adenomas

Author

Shaaban, Ahmed, primary, Dumot, Chloé, additional, Mantziaris, Georgios, additional, Dayawansa, Sam, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdel Karim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad Eldin, Reem M., additional, Ragab Abdelsalam, Ahmed, additional, Liscak, Roman, additional, May, Jaromir, additional, Mashiach, Elad, additional, De Nigris Vasconcellos, Fernando, additional, Bernstein, Kenneth, additional, Kondziolka, Douglas, additional, Speckter, Herwin, additional, Mota, Ruben, additional, Brito, Anderson, additional, Bindal, Shray K., additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Benjamin, Carolina Gesteira, additional, Almeida, Timoteo, additional, Mao, Jennifer Z., additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Palmer, Joshua David, additional, Matsui, Jennifer, additional, Crooks, Joseph, additional, Wegner, Rodney E., additional, Shepard, Matthew J., additional, and Sheehan, Jason P., additional

Published
2024
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