3,417 results on '"Mathieu, C."'
Search Results
2. Cost of care pathways before and after appropriate and inappropriate transfers to the emergency department among nursing home residents: results from the FINE study
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Gombault-Datzenko, E., Costa, N., Mounié, M., Tavassoli, N., Mathieu, C., Roussel, H., Lagarrigue, J. M., Berard, E., Rolland, Y., and Molinier, L.
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- 2024
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3. Writing Retreats Responding to the Needs of Doctoral Candidates through Engagement with Academic Writing
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Tremblay-Wragg, Émilie, Vincent, Cynthia, Mathieu-C., Sara, Lison, Christelle, Ponsin, Annabelle, and Déri, Catherine
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During dissertation writing, PhD candidates face challenges engaging with academic writing, among other things, which leads to their participation in writing retreats with their peers. Developing a better understanding of PhD candidates' needs to optimize engagement with writing is important for improving the overall doctoral experience and reduce attrition. We then conducted a qualitative longitudinal experimental study with PhD candidates from Canadian universities: 15 respondents who participated in a writing retreat and 15 respondents who never participated in such event. Based on our findings, this article presents a complementary perspective to the theoretical model of engagement with writing by Murray (2015). Thereon, we expand on the intersectionality of components (cognitive, physical, social) to illustrate the influence of structured writing activities. These intersections highlight the benefits of writing retreats to answer the needs of PhD candidates to engage with writing: planning dedicated writing periods, implementing effective work methods in environments enabling concentration, and engaging with collective writing activities. By way of supplementing the most recent literature on the subject, we suggest that the participation in structured writing retreats serves as a pedagogical benchmark for graduate programs to offer students comparable conditions in support of their writing requirements to enhance academic success.
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- 2022
4. Academic Writing Groups in Higher Education: History and State of Play
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Déri, Catherine E., Tremblay-Wragg, Émilie, and Mathieu-C., Sara
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Over the past twenty years, graduate studies have seen significant growth, with student numbers more than doubling worldwide. Unfortunately, the Organization for Economic Co-operation and Development continues to report dropout rates averaging 50% for PhD and 40% for master's programs, in all disciplines combined. Among the reasons quoted for abandoning study programs are deficient academic writing competencies that could not only hinder how graduate students progress through their academic journey, but also how they integrate with the scientific community as novice scholars. Accordingly, this article will present an overview of studies related to academic writing groups, which have been identified as one of the strategies to benefit graduate studies. Based on a systematic literature review, we present a chronological account of key issues and concepts that have influenced the phenomenon throughout history. Thereafter, we explain the various characteristics of academic writing groups in order to delineate this phenomenon through the description of its inherent elements and propose an all-encompassing definition. The analysis of 72 documentary sources also allows the observation of trends through the examination of geographical, disciplinary, and methodological factors drawn from scholarly publications. Finally, we highlight considerations for future exploration of academic writing groups used as a pedagogical strategy in the context of higher education, from disciplinary, sociocultural, and gender perspectives.
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- 2022
5. Une méthode d'irrigation par semi-conduites verticales adaptées aux zones sahéliennes des filières. Résultats techniques et prospective de l'organisation des filières. Résultats techniques et prospective de l'organisation des filières
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Mathieu, C.
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Irrigation ,Spacing crops ,Sahel ,Semi ,arid areas ,Senegal ,Agriculture - Abstract
Irrigation Method with Vertical Semi-tube Adapted for Sahel Areas. Technical Results and Prospective about Organization of Production Chain. The difficulty of planting fruit and multipurpose trees in semi-arid areas results from very important water requirements, immediately on plantation and during all the period of growth. A new irrigation method with vertical semi-tube, tested in Senegal permits to water young plants with low water quantity and to succeed plantations in these semi-arid areas. With the success of this method, the extension of orchards of mango and cashew trees will induce a fruit production what risk to saturate the market in short term if the fruit production chain is not structured in due time. The author describes the new irrigation method and prevents about the urgency to organize the producer groups and the fruit production chain.
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- 2006
6. Pépiniéristes privés au Burundi, vers une professionnalisation possible de la foresterie
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Gasc, C. and Mathieu, C.
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Nursery ,Agroforestry ,Forestry ,Exploitation Systems ,Burundi ,Agriculture - Abstract
Private Sector Nursery Owners in Burundi, towards the Professionalization of Forestry. Burundi, a small country of the African Great Lakes Region, has a demographic increase which results in one of the highest population densities on the continent. Problems of deforestation and of firewood and timber scarcity are added to the well know degradation associated with soil erosion. Aware of this new problem, Burundi government stated a national forest project in 1979. During ten years, plants necessary for reforestation have been produced by state-owned nurseries controlled entirely by the forestry project. Currently in inter phase since 1990, the forestry project is faced with an important choice : what system of production to choose : private or project nurseries ? The analysis of each system has permitted to conclude in favour of the maintenance of a system of private production. To stimulate the development of the profession and to progressively decrease its dependence on the forest project, this analysis proposes answers to questions raised, insisting particularly on the significance of monitoring and on the choice of training methods.
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- 2000
7. Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies
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Mathieu C Husser, Nhat P Pham, Chris Law, Flavia RB Araujo, Vincent JJ Martin, and Alisa Piekny
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ipsc ,crispr ,gene editing ,endogenous tagging ,live imaging ,cytokinesis ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Endogenous tags have become invaluable tools to visualize and study native proteins in live cells. However, generating human cell lines carrying endogenous tags is difficult due to the low efficiency of homology-directed repair. Recently, an engineered split mNeonGreen protein was used to generate a large-scale endogenous tag library in HEK293 cells. Using split mNeonGreen for large-scale endogenous tagging in human iPSCs would open the door to studying protein function in healthy cells and across differentiated cell types. We engineered an iPS cell line to express the large fragment of the split mNeonGreen protein (mNG21-10) and showed that it enables fast and efficient endogenous tagging of proteins with the short fragment (mNG211). We also demonstrate that neural network-based image restoration enables live imaging studies of highly dynamic cellular processes such as cytokinesis in iPSCs. This work represents the first step towards a genome-wide endogenous tag library in human stem cells.
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- 2024
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8. Design and Commissioning of the first two CYRC\'e Extension Beamlines
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Bouquerel, E., Traykov, E., Maazouzi, C., Rousseau, M., Pellicioli, M., Andrea, J., Adam, T., Graehling, P., Mathieu, C., Heitz, G., Krauth, M., Oster, D., Foehrenbacher, T., Ruescas, C., Schuler, J., Goerlach, U., and Haas, C.
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Physics - Accelerator Physics - Abstract
CYRC\'e is a TR24 cyclotron installed at the Institut Pluridisciplinaire Hubert Curien (IPHC) of Strasbourg operating at energies of 16-25 MeV and at intensities up to 400 $\mu$A. The accelerator is used to produce and provide radioelements for PET and for SPECT. In 2015, IPHC started to develop a platform with the aim of performing radiobiological experiments. The PRECy platform foresees to contain three-to-five experimental stations linked to beamlines expanded from the second exit port of the cyclotron. This extension allows devoting one of the beamlines for detector studies within the framework of the CMS project. The design, the development and the commissioning of the first two beamlines are discussed in this paper., Comment: 23 pages, 25 figures
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- 2022
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9. The combination of cigarette smoke and solar rays causes effects similar to skin aging in a bilayer skin model
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Alexe Grenier, Mathieu C. Morissette, Patrick J. Rochette, and Roxane Pouliot
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Medicine ,Science - Abstract
Abstract Skin aging is a multifactorial process influenced by internal and external factors. The contribution of different environmental factors has been well established individually in the last few years. On the one hand, man is rarely exposed to a single factor, and on the other hand, there is very little knowledge about how these extrinsic factors may interact with each other or even how the skin may react to chronic exposure. This study aimed to evaluate the effect on skin aging of a chronic co-exposure of tissue-engineered skin substitutes to cigarette smoke extract (CSE) and solar simulator light (SSL). Skin substitutes were reconstructed according to the self-assembly method and then exposed to CSE followed by irradiation with SSL simultaneously transmitting UVA1, visible light and infrared. When skin substitutes were chronically exposed to CSE and SSL, a significant decrease in procollagen I synthesis and the inhibition of Smad2 phosphorylation of the TGF-β signaling pathway were observed. A 6.7-fold increase in MMP-1 activity was also observed when CSE was combined with SSL, resulting in a decrease in collagen III and collagen IV protein expression. The secretory profile resulting from the toxic synergy was investigated and several alterations were observed, notably an increase in the quantities of pro-inflammatory cytokines. The results also revealed the activation of the ERK1/2 (3.4-fold) and JNK (3.3-fold) pathways. Taken together, the results showed that a synergy between the two environmental factors could provoke premature skin aging.
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- 2023
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10. Latest results from the RD42 collaboration on the radiation tolerance of polycrystalline diamond detectors
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Mali, M., Artuso, M., Bäni, L., Bartosik, M., Bellini, V., Bentele, B., Bergonzo, P., Bes, A., Brom, J-M., Chiodini, G., Chren, D., Cindro, V., Claus, G., Collot, J., Cumalat, J., Dabrowski, A., Dauvergne, D., Tchernij, S. Ditalia, Eigen, G., Eremin, V., Everaere, P., Forneris, J., Gallin-Martel, L., Gallin-Martel, M-L., Gan, K.K., Gastal, M., Gentry, A., Goffe, M., Goldstein, J., Golubev, A., Gorišek, A., Grigoriev, E., Grosse-Knetter, J., Hiti, B., Hits, D., Hoarau, C., Hoeferkamp, M., Hosslet, J., Hügging, F., Hutson, C., Jackman, R., Jennings-Moors, R., Kagan, H., Kanxheri, K., Kis, M., Kramberger, G., Kruger, M., Kuleshov, S., Lacoste, A., Lukosi, E., Maazouzi, C., Mandić, I., Marcatili, S., Marino, A., Mathieu, C., Menichelli, M., Mikuž, M., Molle, R., Morozzi, A., Moscatelli, F., Moss, J., Mountain, R., Muraz, J-F., Narazyanan, E.A., Oh, A., Olivero, P., Passeri, D., Pernegger, H., Perrino, R., Picollo, F., Porter, A., Portier, A., Potenza, R., Quadt, A., Rarbi, F., Re, A., Reichmann, M., Roe, S., Rossetto, O., Salter, P., Becerra, D.A. Sanz, Schmidt, C.J., Schnetzer, S., Seidel, S., Servoli, L., Shivaraman, R., Smith, D.S., Sopko, B., Sopko, V., Sorenson, J., Spagnolo, S., Spanier, S., Stenson, K., Stone, R., Stugu, B., Sutera, C., Traeger, M., Trischuk, W., Truccato, M., Tuve, C., Velthuis, J., Verbitskaya, E., Wagner, S., Wallny, R., Welch, J., Wengler, T., Yamouni, M., Zalieckas, J., and Zavrtanik, M.
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- 2024
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11. Itinéraires de la dégradation des terres de savanes soudano-guinéennes à très faible densité de population, l'exemple de la République Centrafricaine jRCA)
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Mathieu, C.
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Land degradation ,Savannas ,Traditional cropping ,Infertilization ,Transhumance ,Mbororo ,Central Africa ,Agriculture - Abstract
Process of soil degradation in the Sudanese-Guinean savannas with low population density ; a case study of the Central African Republic. Most of Central Africa is occupied with Soudano-Guinean savannas and presents one of the lowest population density among those tropical South-Sahara Africa regions. The soil degradation phenomenon caused by traditional cropping and transhumant livestock is however evident despite the low occupation ration of soils. The author analyses the process of this degradation of production area recalling successive circumstances that have induced this agricultural people from primitive cropping system to infertilization of soils and that couple with the progressive movement of nomadic Mbororo breeders toward the southernmost savannas of this country. It seems that the solutions to the technical problems of reestablishment of soil fertility must undergo a radical change in cropping systems going to sedentary life and fertilization by way of the association cropping-livestock production and in a realistic method of grazing management. These changes have to go also with a radical change in relation between rural community and administrative services and a more willing participation from rural population.
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- 1990
12. The combination of cigarette smoke and solar rays causes effects similar to skin aging in a bilayer skin model
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Grenier, Alexe, Morissette, Mathieu C., Rochette, Patrick J., and Pouliot, Roxane
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- 2023
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13. Technical and analytical approach to biventricular pressure-volume loops in swine including a completely endovascular, percutaneous closed-chest large animal model
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David P. Stonko, MD, MS, Mathieu C. Rousseau, MD, Colin Price, BS, Amy Benike, MS, Rebecca N. Treffalls, BS, Nichole E. Brunton, DO, Dorian Rosen, PhD, and Jonathan J. Morrison, MBChB, PhD
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Biventricular pressure-volume loops ,LV PV loops ,RV PV loops ,Endovascular ,Closed-chest ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Pressure-volume (PV) loop analysis is a sophisticated invasive approach to quantifying load-dependent and independent measures of cardiac function. Biventricular (BV) PV loops allow left and right ventricular function to be quantified simultaneously and independently, which is important for conditions and certain physiologic states, such as ventricular decoupling or acute physiologic changes. BV PV loops can be performed in an entirely endovascular, percutaneous, and closed-chest setting. This technique is helpful in a survival animal model, as a percutaneous monitoring system during endovascular device experiments, or in cases where chest wall compliance is being tested or may be a confounder. In this article, we describe the end-to-end implementation of a completely endovascular, totally percutaneous, and closed-chest large animal model to obtain contemporaneous BV PV loops in 40 to 70 kg swine. We describe the associated surgical and technical challenges and our solutions to obtaining endovascular BV PV loops, closed-chest cardiac output, and stroke volume (including validation of the correction factor necessary for thermodilution), as well as how to perform endovascular inferior vena cava occlusion in this swine model. We also include techniques for data acquisition and analysis that are required for this method. : Clinical Relevance: This article describes the end-to-end implementation of a completely endovascular, percutaneous, and closed-chest large animal model for obtaining biventricular pressure-volume loops in swine. This will allow researchers to obtain contemporaneous, continuous left and right ventricular physiology through a minimally invasive procedure that animals can survive and does not alter chest wall compliance. This model may be used to better quantify the physiology during clinical scenarios of ventricular decoupling, during procedures such as transcatheter aortic valve repair or those that alter left ventricular (LV) function, or during the initiation of resuscitative endovascular balloon occlusion of the aorta or extracorporeal cardiopulmonary resuscitation when LV and right ventricular filling become misaligned.
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- 2024
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14. Technical and analytical approach to biventricular pressure-volume loops in swine including a completely endovascular, percutaneous closed-chest large animal model
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Stonko, David P., Rousseau, Mathieu C., Price, Colin, Benike, Amy, Treffalls, Rebecca N., Brunton, Nichole E., Rosen, Dorian, and Morrison, Jonathan J.
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- 2024
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15. New front and back-end electronics for the upgraded GABRIELA detection system
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Hauschild, K., Chakma, R., Lopez-Martens, A., Rezynkina, K., Alaphillipe, V., Gibelin, L., Karkour, N., Linget, D., Yeremin, A. V., Popeko, A. G., Malyshev, O. N., Chepigin, V. I., Svirikhin, A. I., Isaev, A. V., Sokol, E. A., Chelnokov, M. L., Popov, Yu. A., Katrasev, D. E., Kuznetsov, A. N., Kuznetsova, A. A., Tezekbayeva, M. S., Dorvaux, O., Gall, B. J. P., Brionnet, P., Kessaci, K., and Mathieu, C.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The GABRIELA [1] set-up is used at the FLNR to perform detailed nuclear structure studies of transfermium nuclei. Following the modernization of the VASSILISSA separator (SHELS) [2] the GABRIELA detection system has also been upgraded. The characteristics of the upgraded detection system will be presented along with results from some recent electronics tests., Comment: 6 pages, 3 figure, 1 table uncorrected pre-print of EXON 2018 conference proceedings
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- 2019
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16. Recent Results from Polycrystalline CVD Diamond Detectors
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RD42 Collaboration, Bäni, L., Alexopoulos, A., Artuso, M., Bachmair, F., Bartosik, M., Beck, H., Bellini, V., Belyaev, V., Bentele, B., Bes, A., Brom, J. -M., Bruzzi, M., Chiodini, G., Chren, D., Cindro, V., Claus, G., Collot, J., Cumalat, J., Dabrowski, A., D'Alessandro, R., Dauvergne, D., de Boer, W., Dorfer, C., Dünser, M., Eigen, G., Eremin, V., Forcolin, G., Forneris, J., Gallin-Martel, L., Gallin-Martel, M. -L., Gan, K. K., Gastal, M., Goffe, M., Goldstein, J., Golubev, A., Gorišek, A., Grigoriev, E., Grosse-Knetter, J., Grummer, A., Guthoff, M., Hiti, B., Hits, D., Hoeferkamp, M., Hofmann, T., Hosselet, J., Hügging, F., Hutton, C., Janssen, J., Kagan, H., Kanxheri, K., Kass, R., Kis, M., Kramberger, G., Kuleshov, S., Lacoste, A., Lagomarsino, S., Giudice, A. Lo, Paz, I. López, Lukosi, E., Maazouzi, C., Mandić, I., Mathieu, C., Menichelli, M., Mikuž, M., Morozzi, A., Moss, J., Mountain, R., Oh, A., Olivero, P., Passeri, D., Pernegger, H., Perrino, R., Picollo, F., Pomorski, M., Potenza, R., Quadt, A., Rarbi, F., Re, A., Reichmann, M., Roe, S., Becerra, D. A. Sanz, Scaringella, M., Schmidt, C. J., Schnetzer, S., Schioppa, E., Sciortino, S., Scorzoni, A., Seidel, S., Servoli, L., Smith, D. S., Sopko, B., Sopko, V., Spagnolo, S., Spanier, S., Stenson, K., Stone, R., Stugu, B., Sutera, C., Traeger, M., Trischuk, W., Truccato, M., Tuvè, C., Velthuis, J., Venturi, N., Wagner, S., Wallny, R., Wang, J. C., Wermes, N., Yamouni, M., Zalieckas, J., and Zavrtanik, M.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
Diamond is a material in use at many nuclear and high energy facilities due to its inherent radiation tolerance and ease of use. We have characterized detectors based on chemical vapor deposition (CVD) diamond before and after proton irradiation. We present preliminary results of the spatial resolution of unirradiated and irradiated CVD diamond strip sensors. In addition, we measured the pulse height versus particle rate of unirradiated and irradiated polycrystalline CVD (pCVD) diamond pad detectors up to a particle flux of $20\,\mathrm{MHz/cm^2}$ and a fluence up to $4 \times 10^{15}\,n/\mathrm{cm^2}$., Comment: Talk presented at the 2019 Meeting of the Division of Particles and Fields of the American Physical Society (DPF2019), July 29 - August 2, 2019, Northeastern University, Boston, C1907293
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- 2019
17. Co-modulation of T cells and B cells enhances the inhibition of inflammation in experimental hypersensitivity pneumonitis
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Olivier Courtemanche, Carole-Ann Huppé, Pascale Blais Lecours, Ophélie Lerdu, Joanny Roy, Jean-François Lauzon-Joset, Marie-Renée Blanchet, Mathieu C. Morissette, and David Marsolais
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Hypersensitivity pneumonitis ,Extrinsic allergic alveolitis ,S1P1 ,CD69 ,B cells ,Rituximab ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Hypersensitivity pneumonitis (HP) is an interstitial lung disease characterized by antigen-triggered neutrophilic exacerbations. Although CD4+ T cells are sufficient for HP pathogenesis, this never translated into efficient T cell-specific therapies. Increasing evidence shows that B cells also play decisive roles in HP. Here, we aimed to further define the respective contributions of B and T cells in subacute experimental HP. Methods Mice were subjected to a protocol of subacute exposure to the archaeon Methanosphaera stadmanae to induce experimental HP. Using models of adoptive transfers of B cells and T cells in Rag1-deficient mice and of B cell-specific S1P1 deletion, we assessed the importance of B cells in the development of HP by evaluating inflammation in bronchoalveolar lavage fluid. We also aimed to determine if injected antibodies targeting B and/or T cells could alleviate HP exacerbations using a therapeutic course of intervention. Results Even though B cells are not sufficient to induce HP, they strongly potentiate CD4+ T cell-induced HP‑associated neutrophilic inflammation in the airways. However, the reduction of 85% of lung B cells in mice with a CD19-driven S1P1 deletion does not dampen HP inflammation, suggesting that lung B cells are not necessary in large numbers to sustain local inflammation. Finally, we found that injecting antibodies targeting B cells after experimental HP was induced does not dampen neutrophilic exacerbation. Yet, injection of antibodies directed against B cells and T cells yielded a potent 76% inhibition of neutrophilic accumulation in the lungs. This inhibition occurred despite partial, sometimes mild, depletion of B cells and T cells subsets. Conclusions Although B cells are required for maximal inflammation in subacute experimental HP, partial reduction of B cells fails to reduce HP-associated inflammation by itself. However, co-modulation of T cells and B cells yields enhanced inhibition of HP exacerbation caused by an antigenic rechallenge.
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- 2022
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18. Identification of identical BAP1 mutations in a patient’s peritoneal mesothelioma and mucosal melanoma: A precision medicine case study
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Paul Zamiara, Ibrahim Elsharawi, Daniel Gaston, Ryan C. DeCoste, Eoghan Malone, Martin J. Bullock, Mathieu C. Castonguay, and Michael D. Carter
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Multiple primary tumors ,Peritoneal mesothelioma ,Mucosal melanoma ,BRCA1-associated protein 1, human ,Comprehensive genomic profiling ,Precision medicine ,Pathology ,RB1-214 - Abstract
Biomarker testing has increasingly been adopted in oncology for diagnostic, prognostic, and predictive purposes. Several tumor types undergo reflexive biomarker testing, including immunohistochemistry and next generation sequencing (NGS), to screen for hereditary tumor predisposition syndromes and identify optimal treatment regimens. Routine clinical biomarker testing, however, does not identify less common hereditary cancer syndromes, which instead requires comprehensive genomic profiling (CGP). This report describes the case of a patient with occupational exposure to asbestos who developed peritoneal mesothelioma and experienced a dramatic response to platinum-based chemotherapy. Shortly thereafter, he was diagnosed with metastatic sinonasal melanoma. The uncommon co-occurrence of these two primary malignancies prompted analysis of the patient’s mesothelioma by CGP, which identified a pathogenic BAP1 splice site mutation (c.438-1G > A, NM_004656.4, 71 % allele frequency). The melanoma was subsequently evaluated using a clinical NGS panel and found to harbor the same mutation (84 % allele frequency), strongly suggesting that the pathogenic variant is present in the patient’s germline (diagnostic of BAP1 tumor predisposition syndrome). These results enabled recommendation of germline testing and suggestion of active clinical trials of targeted therapy to the treating physician, highlighting the important role of CGP in the delivery of precision medicine.
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- 2023
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19. Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies
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Husser, Mathieu C, primary, Pham, Nhat P, additional, Law, Chris, additional, Araujo, Flavia RB, additional, Martin, Vincent JJ, additional, and Piekny, Alisa, additional
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- 2024
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20. Author response: Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies
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Husser, Mathieu C, primary, Pham, Nhat, additional, Law, Chris, additional, Araujo, Flavia RB, additional, Martin, Vincent, additional, and Piekny, Alisa J, additional
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- 2024
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21. Exploring interlayer Dirac cone coupling in commensurately rotated few-layer graphene on SiC(000-1)
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Mathieu, C., Conrad, E. H., Wang, F., Rault, J. E., Feyer, V., Schneider, C. M., Renault, O., and Barrett, N.
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Condensed Matter - Materials Science - Abstract
We investigate electronic band-structure images in reciprocal space of few layer graphene epitaxially grown on SiC(000-1). In addition to the observation of commensurate rotation angles of the graphene layers, the k-space images recorded near the Fermi edge highlight structures originating from diffraction of the Dirac cones due to the relative rotation of adjacent layers. The 21.9{\deg} and 27{\deg} rotation angles between two sheets of graphene are responsible for a periodic pattern that can be described with a superlattice unit cells. The superlattice generates replicas of Dirac cones with smaller wave vectors, due to a Brillouin zone folding., Comment: 11 pages, 4 figures
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- 2018
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22. Charge spill-out and work function of few-layer graphene on SiC(0001)
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Renault, O., Pascon, A. M., Rotella, H., Kaja, K., Mathieu, C., Rault, J. E., Blaise, P., Poiroux, T., Barrett, N., and Fonseca, L. R. C.
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Condensed Matter - Materials Science - Abstract
We report on the charge spill-out and work function of epitaxial few-layer graphene on 6H-SiC(0001). Experiments from high-resolution, energy-filtered X-ray photoelectron emission microscopy (XPEEM) are combined with ab initio Density Functional Theory calculations using a relaxed interface model. Work function values obtained from theory and experiments are in qualitative agreement, reproducing the previously observed trend of increasing work function with each additional graphene plane. Electrons transfer at the SiC/graphene interface through a buffer layer causes an interface dipole moment which is at the origin of the graphene work function modulation. The total charge transfer is independent of the number of graphene layers, and is consistent with the constant binding energy of the SiC component of the C 1s core-level measured by XPEEM. Charge leakage into vacuum depends on the number of graphene layers explaining why the experimental, layer-dependent C 1s-graphene core-level binding energy shift does not rigidly follow that of the work function. Thus, a combination of charge transfer at the SiC/graphene interface and charge spill-out into vacuum resolves the apparent discrepancy between the experimental work function and C1s binding energy., Comment: 14 pages, 9 figures
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- 2018
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23. Full field electron spectromicroscopy applied to ferroelectric materials
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Barrett, N., Rault, J. E., Wang, J. L., Mathieu, C., Locatelli, A., Mentes, T. O., Nino, M. A., Fusil, S., Bibes, M., Barthelemy, A., Sando, D., Ren, W., Prosandeev, S., Bellaiche, L., Vilquin, B., Petraru, A., Krug, I. P., and Schneider, C. M.
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Condensed Matter - Materials Science - Abstract
The application of PhotoEmission Electron Microscopy (PEEM) and Low Energy Electron Microscopy (LEEM) techniques to the study of the electronic and chemical structure of ferroelectric materials is reviewed. Electron optics in both techniques gives spatial resolution of a few tens of nanometres. PEEM images photoelectrons whereas LEEM images reflected and elastically backscattered electrons. Both PEEM and LEEM can be used in direct and reciprocal space imaging. Together, they provide access to surface charge, work function, topography, chemical mapping, surface crystallinity and band structure. Examples of applications for the study of ferroelectric thin films and single crystals are presented., Comment: 15 pages, 9 figures
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- 2018
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24. Polarization sensitive surface band structure of doped BaTiO3(001)
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Rault, J. E., Dionot, J., Mathieu, C., Feyer, V., Schneider, C. M., Geneste, G., and Barrett, N.
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Condensed Matter - Materials Science - Abstract
We present a spatial and wave-vector resolved study of the electronic structure of micron sized ferroelectric domains at the surface of a BaTiO3(001) single crystal. The n-type doping of the BaTiO3 is controlled by in-situ vacuum and oxygen annealing, providing experimental evidence of a surface paraelectric-ferroelectric transition below a critical doping level. Real space imaging of photoemission threshold, core level and valence band spectra show contrast due to domain polarization. Reciprocal space imaging of the electronic structure using linearly polarized light provides unambiguous evidence for the presence of both in and out-of plane polarization with two and fourfold symmetry, respectively. The results agree well with first principles calculations., Comment: 6 pages, 5 figures
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- 2018
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25. Control of surface potential at polar domain walls in a nonpolar oxide
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Nataf, G. F., Guennou, M., Kreisel, J., Hicher, P., Haumont, R., Aktas, O., Salje, E. K. H., Tortech, L., Mathieu, C., Martinotti, D., and Barrett, N.
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Condensed Matter - Materials Science - Abstract
Ferroic domain walls could play an important role in microelectronics, given their nanometric size and often distinct functional properties. Until now, devices and device concepts were mostly based on mobile domain walls in ferromagnetic and ferroelectric materials. A less explored path is to make use of polar domain walls in nonpolar ferroelastic materials. Indeed, while the polar character of ferroelastic domain walls has been demonstrated, polarization control has been elusive. Here, we report evidence for the electrostatic signature of the domain-wall polarization in nonpolar calcium titanate (CaTiO3). Macroscopic mechanical resonances excited by an ac electric field are observed as a signature of a piezoelectric response caused by polar walls. On the microscopic scale, the polarization in domain walls modifies the local surface potential of the sample. Through imaging of surface potential variations, we show that the potential at the domain wall can be controlled by electron injection. This could enable devices based on nondestructive information readout of surface potential., Comment: 30 pages, 12 figures
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- 2018
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26. HER2 testing in metastatic breast cancer – Is reflex ISH testing necessary on HER2 IHC-equivocal (2+) cases?
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Liwski, Christopher R., Castonguay, Mathieu C., Barnes, Penny J., Rayson, Daniel, and Bethune, Gillian C.
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- 2022
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- View/download PDF
27. Co-modulation of T cells and B cells enhances the inhibition of inflammation in experimental hypersensitivity pneumonitis
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Courtemanche, Olivier, Huppé, Carole-Ann, Blais Lecours, Pascale, Lerdu, Ophélie, Roy, Joanny, Lauzon-Joset, Jean-François, Blanchet, Marie-Renée, Morissette, Mathieu C., and Marsolais, David
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- 2022
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- View/download PDF
28. Bien-être, satisfaction au travail et conflit travail–famille : une perspective centrée sur l’influence du leadership
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Hartmann, E. and Mathieu, C.
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- 2022
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29. Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA
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Mathieu C. Husser, Imge Ozugergin, Tiziana Resta, Vincent J. J. Martin, and Alisa J. Piekny
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cytokinesis ,RhoA ,actomyosin ,CRISPR ,microscopy ,Biology (General) ,QH301-705.5 - Abstract
Cytokinesis is required to physically separate the daughter cells at the end of mitosis. This crucial process requires the assembly and ingression of an actomyosin ring, which must occur with high fidelity to avoid aneuploidy and cell fate changes. Most of our knowledge of mammalian cytokinesis was generated using over-expressed transgenes in HeLa cells. Over-expression can introduce artefacts, while HeLa are cancerous human cells that have lost their epithelial identity, and the mechanisms controlling cytokinesis in these cells could be vastly different from other cell types. Here, we tagged endogenous anillin, Ect2 and RhoA with mNeonGreen and characterized their localization during cytokinesis for the first time in live human cells. Comparing anillin localization in multiple cell types revealed cytokinetic diversity with differences in the duration and symmetry of ring closure, and the timing of cortical recruitment. Our findings show that the breadth of anillin correlates with the rate of ring closure, and support models where cell size or ploidy affects the cortical organization, and intrinsic mechanisms control the symmetry of ring closure. This work highlights the need to study cytokinesis in more diverse cell types, which will be facilitated by the reagents generated for this study.
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- 2022
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30. Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies
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Husser, Mathieu C., primary, Pham, Nhat P., additional, Law, Chris, additional, Araujo, Flavia R. B., additional, Martin, Vincent J.J., additional, and Piekny, Alisa, additional
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- 2024
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31. Author Response: Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies
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Husser, Mathieu C., primary, Pham, Nhat P., additional, Law, Chris, additional, Araujo, Flavia R. B., additional, Martin, Vincent J.J., additional, and Piekny, Alisa, additional
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- 2024
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- View/download PDF
32. Characterization of a new generation of silicon detector: The SIRIUS side “Strippy-Pad” detector
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Brionnet, P., Faure, H., Dorvaux, O., Gall, B., Hauschild, K., Mathieu, C., and Gamelin, E.
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- 2021
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33. Contraintes techniques et sociales en conservation du sol et des eaux en zone à très forte densité de population : l'exemple des montagnes du Mumirwa au Burundi
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Mathieu, C.
- Subjects
Agriculture - Abstract
Study of the influence of cutting and picking of leaves on the quality of cassava tuber (Manihot esculenta Crantz cv. "F46"). The Burundi country located in mountainous tropical region of Central Africa, presents one of the highest density population among those overpopulated regions. The extreme soil occupation phenomenon at the greatest slope poses a serious problems of soil erosion. The author analyses the physical and social constraints of soil conservation and water management problems in a such context. It seems that the solutions to the technical problems of erosion control must undergo with a radical change in relation between rural community and administration in the way of more collaboration and comprehension of administrative services and more willingly participation from rural population.
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- 1987
34. How GDPR Enhances Transparency and Fosters Pseudonymisation in Academic Medical Research
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Verhenneman, G., Claes, K., Derèze, J.J., Herijgers, P., Mathieu, C., Rademakers, F.E., Reyda, R., and Vanautgaerden, M.
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- 2020
35. Characterization of PARIS LaBr$_3$(Ce)-NaI(Tl) phoswich detectors upto $E_\gamma$ $\sim$ 22 MeV
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Ghosh, C., Nanal, V., Pillay, R. G., K. V, Anoop, Dokania, N., Pal, Sanjoy, Pose, M. S., Mishra, G., Rout, P. C., Kumar, Suresh, Pandit, Deepak, Mondal, Debasish, Pal, Surajit, Banerjee, S. R., Napiorkowski, Paweł J., Dorvaux, Oliver, Kihel, S., Mathieu, C., and Maj, A.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
In order to understand the performance of the PARIS (Photon Array for the studies with Radioactive Ion and Stable beams) detector, detailed characterization of two individual phoswich (LaBr$_3$(Ce)-NaI(Tl)) elements has been carried out. The detector response is investigated over a wide range of $E_{\gamma}$ = 0.6 to 22.6 MeV using radioactive sources and employing $^{11}B(p,\gamma)$ reaction at $E_p$ = 163 keV and $E_p$ = 7.2 MeV. The linearity of energy response of the LaBr$_3$(Ce) detector is tested upto 22.6 MeV using three different voltage dividers. The data acquisition system using CAEN digitizers is set up and optimized to get the best energy and time resolution. The energy resolution of $\sim$ 2.1% at $E_\gamma$ = 22.6~MeV is measured for the configuration giving best linearity upto high energy. Time resolution of the phoswich detector is measured with a $^{60}$Co source after implementing CFD algorithm for the digitized pulses and is found to be excellent (FWHM $\sim$ 315~ps). In order to study the effect of count rate on detectors, the centroid position and width of the $E_{\gamma}$ = 835~keV peak were measured upto 220 kHz count rate. The measured efficiency data with radioactive sources are in good agreement with GEANT4 based simulations. The total energy spectrum after the add-back of energy signals in phoswich components is also presented., Comment: Accepted in JINST
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- 2016
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36. Smoking status impacts treatment efficacy in smoke-induced lung inflammation: A pre-clinical study
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Nadia Milad, Marie Pineault, Félix Tremblay, Joanie Routhier, Ariane Lechasseur, Marie-Josée Beaulieu, Sophie Aubin, and Mathieu C. Morissette
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cigarette smoking ,COPD ,biologics ,monoclonal antibodies ,smoking status ,treatment timing ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Rationale: Smoking status and smoking history remain poorly accounted for as variables that could affect the efficacy of new drugs being tested in chronic obstructive pulmonary disease (COPD) patients. As a proof of concept, we used a pre-clinical model of cigarette smoke (CS) exposure to compare the impact of treatment during active CS exposure or during the cessation period on the anti-inflammatory effects IL-1α signaling blockade.Methods: Mice were exposed to CS for 2 weeks, followed by a 1-week cessation, then acutely re-exposed for 2 days. Mice were treated with an anti-IL-1α antibody either during CS exposure or during cessation and inflammatory outcomes were assessed.Results: We found that mice re-exposed to CS displayed reduced neutrophil counts and cytokine levels in the bronchoalveolar lavage (BAL) compared to mice exposed only acutely. Moreover, we found that treatment with an anti-IL-1α antibody during the initial CS exposure delayed inflammatory processes and interfered with pulmonary adaptation, leading to rebound pulmonary neutrophilia, increased BAL cytokine secretion (CCL2) and upregulated Mmp12 expression. Conversely, administration of anti-IL-1α during cessation had the opposite effect, improving BAL neutrophilia, decreasing CCL2 levels and reducing Mmp12 expression.Discussion: These results suggest that pulmonary adaptation to CS exposure dampens inflammation and blocking IL-1α signaling during CS exposure delays the inflammatory response. More importantly, the same treatment administered during cessation hastens the return to pulmonary inflammatory homeostasis, strongly suggesting that smoking status and treatment timing should be considered when testing new biologics in COPD.
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- 2022
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37. Malat1 deficiency prevents hypoxia-induced lung dysfunction by protecting the access to alveoli
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Sandrine Sallé-Lefort, Stéphanie Miard, Cyndi Henry, Christian Arias-Reyes, François Marcouiller, Marie-Josée Beaulieu, Sophie Aubin, Ariane Lechasseur, Éric Jubinville, David Marsolais, Mathieu C. Morissette, Vincent Joseph, Jorge Soliz, Ynuk Bossé, and Frédéric Picard
- Subjects
lung ,respiration ,alveolar volume ,methacholine ,elastance ,resistance ,Physiology ,QP1-981 - Abstract
Hypoxia is common in lung diseases and a potent stimulator of the long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1). Herein, we investigated the impact of Malat1 on hypoxia-induced lung dysfunction in mice. Malat1-deficient mice and their wild-type littermates were tested after 8 days of normoxia or hypoxia (10% oxygen). Hypoxia decreased elastance of the lung by increasing lung volume and caused in vivo hyperresponsiveness to methacholine without altering the contraction of airway smooth muscle. Malat1 deficiency also modestly decreased lung elastance but only when tested at low lung volumes and without altering lung volume and airway smooth muscle contraction. The in vivo responsiveness to methacholine was also attenuated by Malat1 deficiency, at least when elastance, a readout sensitive to small airway closure, was used to assess the response. More impressively, in vivo hyperresponsiveness to methacholine caused by hypoxia was virtually absent in Malat1-deficient mice, especially when hysteresivity, a readout sensitive to small airway narrowing heterogeneity, was used to assess the response. Malat1 deficiency also increased the coefficient of oxygen extraction and decreased ventilation in conscious mice, suggesting improvements in gas exchange and in clinical signs of respiratory distress during natural breathing. Combined with a lower elastance at low lung volumes at baseline, as well as a decreased propensity for small airway closure and narrowing heterogeneity during a methacholine challenge, these findings represent compelling evidence suggesting that the lack of Malat1 protects the access to alveoli for air entering the lung.
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- 2022
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38. Age-related histologic features of the sinoatrial node from normal human hearts during the first 10 decades of life: a study of 200 cases
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Bois, Melanie C., Wu, Cecilia W., Martinez, Christine M., Castonguay, Mathieu C., Jenkins, Sarah M., and Maleszewski, Joseph J.
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- 2021
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39. Syndrome génito-urinaire de la ménopause (SGUM). RPC les femmes ménopausées du CNGOF et du GEMVi
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Hocké, C., Diaz, M., Bernard, V., Frantz, S., Lambert, M., Mathieu, C., and Grellety-Cherbero, M.
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- 2021
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40. The association of alvimopan treatment with postoperative outcomes after abdominal surgery: A systematic review across different surgical procedures and contexts of perioperative care
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Alhashemi, Mohsen, Hamad, Raphael, El-Kefraoui, Charbel, Blouin, Mathieu C., Amar-Zifkin, Alexandre, Landry, Tara, Lee, Lawrence, Baldini, Gabriele, Feldman, Liane S., and Fiore, Julio F., Jr.
- Published
- 2021
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- View/download PDF
41. Étude comparative de l’influence du style de leadership sur la satisfaction au travail chez les policiers
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Hinse, E. and Mathieu, C.
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- 2021
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42. Framework Implementation of the INSPIRE ICOPE-CARE Program in Collaboration with the World Health Organization (WHO) in the Occitania Region
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Tavassoli, Neda, Piau, A., Berbon, C., de Kerimel, J., Lafont, C., De Souto Barreto, P., Guyonnet, S., Takeda, C., Carrie, I., Angioni, D., Paris, F., Mathieu, C., Ousset, P. J., Balardy, L., Voisin, T., Sourdet, S., Delrieu, J., Bezombes, V., Pons-Pretre, V., Andrieu, S., Nourhashemi, F., Rolland, Y., Soto, M. E., Beard, J., Sumi, Y., Araujo Carvalho, I., and Vellas, B.
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- 2021
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43. Trapping in irradiated p-on-n silicon sensors at fluences anticipated at the HL-LHC outer tracker
- Author
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Adam, W., Bergauer, T., Dragicevic, M., Friedl, M., Fruehwirth, R., Hoch, M., Hrubec, J., Krammer, M., Treberspurg, W., Waltenberger, W., Alderweireldt, S., Beaumont, W., Janssen, X., Luyckx, S., Van Mechelen, P., Van Remortel, N., Van Spilbeeck, A., Barria, P., Caillol, C., Clerbaux, B., De Lentdecker, G., Dobur, D., Favart, L., Grebenyuk, A., Lenzi, Th., Léonard, A., Maerschalk, Th., Mohammadi, A., Perniè, L., Randle-Conde, A., Reis, T., Seva, T., Thomas, L., Velde, C. Vander, Vanlaer, P., Wang, J., Zenoni, F., Zeid, S. Abu, Blekman, F., De Bruyn, I., D'Hondt, J., Daci, N., Deroover, K., Heracleous, N., Keaveney, J., Lowette, S., Moreels, L., Olbrechts, A., Python, Q., Tavernier, S., Van Mulders, P., Van Onsem, G., Van Parijs, I., Strom, D. A., Caudron, A., Ceard, L., De Callatay, B., Delaere, C., Pree, T. Du, Forthomme, L., Giammanco, A., Hollar, J., Jez, P., Michotte, D., Nuttens, C., Perrini, L., Pagano, D., Quertenmont, L., Selvaggi, M., Marono, M. Vidal, Beliy, N., Caebergs, T., Daubie, E., Hammad, G. H., Härkönen, J., Lampén, T., Luukka, P. -R., Mäenpää, T., Peltola, T., Tuominen, E., Tuovinen, E., Eerola, P., Tuuva, T., Beaulieu, G., Boudoul, G., Combaret, C., Contardo, D., Gallbit, G., Lumb, N., Mathez, H., Mirabito, L., Perries, S., Sabes, D., Donckt, M. Vander, Verdier, P., Viret, S., Zoccarato, Y., Agram, J. -L., Conte, E., Fontaine, J. -Ch., Andrea, J., Bloch, D., Bonnin, C., Brom, J. -M., Chabert, E., Charles, L., Goetzmann, Ch., Gross, L., Hosselet, J., Mathieu, C., Richer, M., Skovpen, K., Autermann, C., Edelhoff, M., Esser, H., Feld, L., Karpinski, W., Klein, K., Lipinski, M., Ostapchuk, A., Pierschel, G., Preuten, M., Raupach, F., Sammet, J., Schael, S., Schwering, G., Wittmer, B., Wlochal, M., Zhukov, V., Pistone, C., Fluegge, G., Kuensken, A., Geisler, M., Pooth, O., Stahl, A., Bartosik, N., Behr, J., Burgmeier, A., Calligaris, L., Dolinska, G., Eckerlin, G., Eckstein, D., Eichhorn, T., Fluke, G., Garcia, J. Garay, Gizhko, A., Hansen, K., Harb, A., Hauk, J., Kalogeropoulos, A., Kleinwort, C., Korol, I., Lange, W., Lohmann, W., Mankel, R., Maser, H., Mittag, G., Muhl, C., Mussgiller, A., Nayak, A., Ntomari, E., Perrey, H., Pitzl, D., Schroeder, M., Seitz, C., Spannagel, S., Zuber, A., Biskop, H., Blobel, V., Buhmann, P., Centis-Vignali, M., Draeger, A. -R., Erfle, J., Garutti, E., Haller, J., Hoffmann, M., Junkes, A., Lapsien, T., Mättig, S., Matysek, M., Perieanu, A., Poehlsen, J., Poehlsen, T., Scharf, Ch., Schleper, P., Schmidt, A., Sola, V., Steinbrück, G., Wellhausen, J., Barvich, T., Barth, Ch., Boegelspacher, F., De Boer, W., Butz, E., Casele, M., Colombo, F., Dierlamm, A., Eber, R., Freund, B., Hartmann, F., Hauth, Th., Heindl, S., Hoffmann, K. -H., Husemann, U., Kornmeyer, A., Mallows, S., Muller, Th., Nuernberg, A., Printz, M., Simonis, H. J., Steck, P., Weber, M., Weiler, Th., Bhardwaj, A., Kumar, A., Ranjan, K., Bakhshiansohl, H., Behnamian, H., Khakzad, M., Naseri, M., Cariola, P., De Robertis, G., Fiore, L., Franco, M., Loddo, F., Sala, G., Silvestris, L., Creanza, D., De Palma, M., Maggi, G., My, S., Selvaggi, G., Albergo, S., Cappello, G., Chiorboli, M., Costa, S., Giordano, F., Di Mattia, A., Potenza, R., Saizu, M. A., Tricomi, A., Tuvè, C., Barbagli, G., Brianzi, M., Ciaranfi, R., Civinini, C., Gallo, E., Meschini, M., Paoletti, S., Sguazzoni, G., Ciulli, V., D'Alessandro, R., Gonzi, S., Gori, V., Focardi, E., Lenzi, P., Scarlini, E., Tropiano, A., Viliani, L., Ferro, F., Robutti, E., Vetere, M. Lo, Gennai, S., Malvezzi, S., Menasce, D., Moroni, L., Pedrini, D., Dinardo, M., Fiorendi, S., Manzoni, R. A., Azzi, P., Bacchetta, N., Bisello, D., Dall'Osso, M., Dorigo, T., Giubilato, P., Pozzobon, N., Tosi, M., Zucchetta, A., De Canio, F., Gaioni, L., Manghisoni, M., Nodari, B., Re, V., Traversi, G., Comotti, D., Ratti, L., Bilei, G. M., Bissi, L., Checcucci, B., Magalotti, D., Menichelli, M., Saha, A., Servoli, L., Storchi, L., Biasini, M., Conti, E., Ciangottini, D., Fanò, L., Lariccia, P., Mantovani, G., Passeri, D., Placidi, P., Salvatore, M., Santocchia, A., Solestizi, L. A., Spiezia, A., Androsov, K., Azzurri, P., Arezzini, S., Bagliesi, G., Basti, A., Boccali, T., Bosi, F., Castaldi, R., Ciampa, A., Cioccid, M. A., Dell'Orso, R., Fedi, G., Giassi, A., Grippod, M. T., Lomtadze, T., Magazzu, G., Mazzoni, E., Minuti, M., Moggi, A., Moond, C. S., Morsani, F., Palla, F., Palmonari, F., Raffaelli, F., Savoy-Navarro, A., Serban, A. T., Spagnolo, P., Tenchini, R., Venturi, A., Verdini, P. G., Martini, L., Messineo, A., Rizzi, A., Tonelli, G., Calzolari, F., Donato, S., Fiori, F., Ligabue, F., Vernieri, C., Demaria, N., Rivetti, A., Bellan, R., Casasso, S., Costa, M., Covarelli, R., Migliore, E., Monteil, E., Musich, M., Pacher, L., Ravera, F., Romero, A., Solano, A., Trapani, P., Echeverria, R. Jaramillo, Fernandez, M., Gomez, G., Moya, D., Sanchez, F. J. Gonzalez, Sanchez, F. J. Munoz, Vila, I., Virto, A. L., Abbaneo, D., Ahmed, I., Albert, E., Auzinger, G., Berruti, G., Bianchi, G., Blanchot, G., Breuker, H., Ceresa, D., Christiansen, J., Cichy, K., Daguin, J., D'Alfonso, M., D'Auria, A., Detraz, S., De Visscher, S., Deyrail, D., Faccio, F., Felici, D., Frank, N., Gill, K., Giordano, D., Harris, P., Honma, A., Kaplon, J., Kornmayer, A., Kottelat, L., Kovacs, M., Mannelli, M., Marchioro, A., Marconi, S., Martina, S., Mersi, S., Michelis, S., Moll, M., Onnela, A., Pakulski, T., Pavis, S., Peisert, A., Pernot, J. -F., Petagna, P., Petrucciani, G., Postema, H., Rose, P., Rzonca, M., Stoye, M., Tropea, P., Troska, J., Tsirou, A., Vasey, F., Vichoudis, P., Verlaat, B., Zwalinski, L., Bachmair, F., Becker, R., Bäni, L., di Calafiori, D., Casal, B., Djambazov, L., Donega, M., Dünser, M., Eller, P., Grab, C., Hits, D., Horisberger, U., Hoss, J., Kasieczka, G., Lustermann, W., Mangano, B., Marionneau, M., del Arbol, P. Martinez Ruiz, Masciovecchio, M., Perrozzi, L., Roeser, U., Rossini, M., Starodumov, A., Takahashi, M., Wallny, R., Amsler, C., Bösiger, K., Caminada, L., Canelli, F., Chiochia, V., de Cosa, A., Galloni, C., Hreus, T., Kilminster, B., Lange, C., Maier, R., Ngadiuba, J., Pinna, D., Robmann, P., Taroni, S., Yang, Y., Bertl, W., Deiters, K., Erdmann, W., Horisberger, R., Kaestli, H. -C., Kotlinski, D., Langenegger, U., Meier, B., Rohe, T., Streuli, S., Chen, P. -H., Dietz, C., Grundler, U., Hou, W. -S., Lu, R. -S., Moya, M., Wilken, R., Cussans, D., Flacher, H., Goldstein, J., Grimes, M., Jacob, J., Nasr-Storey, S. Seif El, Cole, J., Hobson, P., Leggat, D., Reid, I. D., Teodorescu, L., Bainbridge, R., Dauncey, P., Fulcher, J., Hall, G., Magnan, A. -M., Pesaresi, M., Raymond, D. M., Uchida, K., Coughlan, J. A., Harder, K., Ilic, J., Tomalin, I. R., Garabedian, A., Heintz, U., Narain, M., Nelson, J., Sagir, S., Speer, T., Swanson, J., Tersegno, D., Watson-Daniels, J., Chertok, M., Conway, J., Conway, R., Flores, C., Lander, R., Pellett, D., Ricci-Tam, F., Squires, M., Thomson, J., Yohay, R., Burt, K., Ellison, J., Hanson, G., Malberti, M., Olmedo, M., Cerati, G., Sharma, V., Vartak, A., Yagil, A., Della Porta, G. Zevi, Dutta, V., Gouskos, L., Incandela, J., Kyre, S., McColl, N., Mullin, S., White, D., Cumalat, J. P., Ford, W. T., Gaz, A., Krohn, M., Stenson, K., Wagner, S. R., Baldin, B., Bolla, G., Burkett, K., Butler, J., Cheung, H., Chramowicz, J., Christian, D., Cooper, W. E., Deptuch, G., Derylo, G., Gingu, C., Gruenendahl, S., Hasegawa, S., Hoff, J., Howell, J., Hrycyk, M., Jindariani, S., Johnson, M., Jung, A., Joshi, U., Kahlid, F., Lei, C. M., Lipton, R., Liu, T., Los, S., Matulik, M., Merkel, P., Nahn, S., Prosser, A., Rivera, R., Shenai, A., Spiegel, L., Tran, N., Uplegger, L., Voirin, E., Yin, H., Adams, M. R., Berry, D. R., Evdokimov, A., Evdokimov, O., Gerber, C. E., Hofman, D. J., Kapustka, B. K., O'Brien, C., Gonzalez, D. I. Sandoval, Trauger, H., Turner, P., Parashar, N., Stupak, J., Bortoletto, D., Bubna, M., Hinton, N., Jones, M., Miller, D. H., Shi, X., Tan, P., Baringer, P., Bean, A., Benelli, G., Gray, J., Majumder, D., Noonan, D., Sanders, S., Stringer, R., Ivanov, A., Makouski, M., Skhirtladze, N., Taylor, R., Anderson, I., Fehling, D., Gritsan, A., Maksimovic, P., Martin, C., Nash, K., Osherson, M., Swartz, M., Xiao, M., Acosta, J. G., Cremaldi, L. M., Oliveros, S., Perera, L., Summers, D., Bloom, K., Bose, S., Claes, D. R., Dominguez, A., Fangmeier, C., Suarez, R. Gonzalez, Meier, F., Monroy, J., Hahn, K., Sevova, S., Sung, K., Trovato, M., Bartz, E., Duggan, D., Halkiadakis, E., Lath, A., Park, M., Schnetzer, S., Stone, R., Walker, M., Malik, S., Mendez, H., Vargas, J. E. Ramirez, Alyari, M., Dolen, J., George, J., Godshalk, A., Iashvili, I., Kaisen, J., Kharchilava, A., Rappoccio, S., Alexander, J., Chaves, J., Chu, J., Dittmer, S., Kaufman, G., Mirman, N., Ryd, A., Salvati, E., Skinnari, L., Thom, J., Thompson, J., Tucker, J., Winstrom, L., Akgün, B., Ecklund, K. M., Nussbaum, T., Zabel, J., Betchart, B., Demina, R., Hindrichs, O., Petrillo, G., Eusebi, R., Osipenkov, I., Perloff, A., Ulmer, K. A., Delannoy, A. G., D'Angelo, P., and Johns, W.
- Subjects
Physics - Instrumentation and Detectors - Abstract
The degradation of signal in silicon sensors is studied under conditions expected at the CERN High-Luminosity LHC. 200 $\mu$m thick n-type silicon sensors are irradiated with protons of different energies to fluences of up to $3 \cdot 10^{15}$ neq/cm$^2$. Pulsed red laser light with a wavelength of 672 nm is used to generate electron-hole pairs in the sensors. The induced signals are used to determine the charge collection efficiencies separately for electrons and holes drifting through the sensor. The effective trapping rates are extracted by comparing the results to simulation. The electric field is simulated using Synopsys device simulation assuming two effective defects. The generation and drift of charge carriers are simulated in an independent simulation based on PixelAV. The effective trapping rates are determined from the measured charge collection efficiencies and the simulated and measured time-resolved current pulses are compared. The effective trapping rates determined for both electrons and holes are about 50% smaller than those obtained using standard extrapolations of studies at low fluences and suggests an improved tracker performance over initial expectations.
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- 2015
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44. Increased mast cell density is associated with decreased fibrosis in human atrial tissue
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Legere, Stephanie A., Haidl, Ian D., Castonguay, Mathieu C., Brunt, Keith R., Légaré, Jean-François, and Marshall, Jean S.
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- 2020
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45. Writing Retreats Responding to the Needs of Doctoral Candidates Through Engagement with Academic Writing
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Émilie Tremblay-Wragg, Cynthia Vincent, Sara Mathieu-C., Christelle Lison, Annabelle Ponsin, and Catherine Déri
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writing retreats ,academic writing ,doctoral education ,engagement with writing ,dissertation ,Education (General) ,L7-991 - Abstract
During dissertation writing, PhD candidates face challenges engaging with academic writing, among other things, which leads to their participation in writing retreats with their peers. Developing a better understanding of PhD candidates’ needs to optimize engagement with writing is important for improving the overall doctoral experience and reduce attrition. We then conducted a qualitative longitudinal experimental study with PhD candidates from Canadian universities: 15 respondents who participated in a writing retreat and 15 respondents who never participated in such event. Based on our findings, this article presents a complementary perspective to the theoretical model of engagement with writing by Murray (2015). Thereon, we expand on the intersectionality of components (cognitive, physical, social) to illustrate the influence of structured writing activities. These intersections highlight the benefits of writing retreats to answer the needs of PhD candidates to engage with writing: planning dedicated writing periods, implementing effective work methods in environments enabling concentration, and engaging with collective writing activities. By way of supplementing the most recent literature on the subject, we suggest that the participation in structured writing retreats serves as a pedagogical benchmark for graduate programs to offer students comparable conditions in support of their writing requirements to enhance academic success.
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- 2022
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46. New test beam results of 3D and pad detectors constructed with poly-crystalline CVD diamond
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Reichmann, M., Alexopoulos, A., Artuso, M., Bachmair, F., Bäni, L., Bartosik, M., Beacham, J., Beck, H., Bellini, V., Belyaev, V., Bentele, B., Bes, A., Brom, J-M., Bruzzi, M., Chiodini, G., Chren, D., Cindro, V., Claus, G., Collot, J., Cumalat, J., Dabrowski, A., D’Alessandro, R., Dauvergne, D., Boer, W. de, Dick, S., Dorfer, C., Dünser, M., Eigen, G., Eremin, V., Forcolin, G.T., Forneris, J., Gallin-Martel, L., Gallin-Martel, M.L., Gan, K.K., Gastal, M., Giroletti, C., Goffe, M., Goldstein, J., Golubev, A., Gorišek, A., Grigoriev, E., Grosse-Knetter, J., Grummer, A., Gui, B., Guthoff, M., Hiti, B., Hits, D., Hoeferkamp, M., Hofmann, T., Hosselet, J., Hostachy, J-Y., Hügging, F., Hutton, C., Janssen, J., Kagan, H., Kanxheri, K., Kasieczka, G., Kass, R., Kis, M., Kramberger, G., Kuleshov, S., Lacoste, A., Lagomarsino, S., Giudice, A. Lo, Paz, I. López, Lukosi, E., Maazouzi, C., Mandic, I., Marino, A., Mathieu, C., Menichelli, M., Mikuž, M., Morozzi, A., Moss, J., Mountain, R., Oh, A., Olivero, P., Passeri, D., Pernegger, H., Perrino, R., Piccini, M., Picollo, F., Pomorski, M., Potenza, R., Quadt, A., Rarbi, F., Re, A., Roe, S., Becerra, D.A. Sanz, Scaringella, M., Schmidt, C.J., Schioppa, E., Schnetzer, S., Sciortino, S., Scorzoni, A., Seidel, S., Servoli, L., Smith, D.S., Sopko, B., Sopko, V., Spagnolo, S., Spanier, S., Stenson, K., Stone, R., Stugo, B., Sutera, C., Tannenwald, B., Traeger, M., Trischuk, W., Tromson, D., Truccato, M., Tuve, C., Velthuis, J., Venturi, N., Wagner, S., Wallny, R., Wang, J.C., Weingarten, J., Weiss, C., Wermes, N., Yamouni, M., Zalieckas, M., Zavrtanik, M., Salter, P.S., Chmeissani, M., Grinstein, S., and Furelos, D. Vazquez
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- 2020
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47. Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies
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Husser, Mathieu C., primary, Pham, Nhat P., additional, Law, Chris, additional, Araujo, Flavia R. B., additional, Martin, Vincent J.J., additional, and Piekny, Alisa, additional
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- 2023
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48. EFFICACY AND SAFETY OF ONCE-WEEKLY INSULIN ICODEC VERSUS ONCE-DAILY INSULIN DEGLUDEC IN TYPE 1 DIABETES: ONWARDS 6
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Russell-Jones, D., primary, Babazono, T., additional, Cailleteau, R., additional, Engberg, S., additional, Irace, C., additional, Kjaersgaard, M., additional, Mathieu, C., additional, Rosenstock, J., additional, Woo, V., additional, and Klonoff, D., additional
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- 2023
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49. Lung Tissue Transcriptomics Reveal Associations between Thymic Stromal Lymphopoietin Signaling, Mast Cells, and Airway Obstruction in Active Smokers.
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Milad, Nadia, Aubin, Sophie, Racine, Christine, Maltais, François, Bossé, Yohan, and Morissette, Mathieu C.
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LUNGS ,THYMIC stromal lymphopoietin ,MAST cells ,RESPIRATORY obstructions ,TRANSCRIPTOMES ,ADRENERGIC beta agonists - Abstract
This letter discusses a study that investigated the associations between thymic stromal lymphopoietin (TSLP) signaling, mast cells, and airway obstruction in active smokers. The study used lung tissue transcriptomics and clinical data from 213 active smokers to analyze the levels of TSLP and CRLF2 transcripts in relation to clinical features and predicted immune cell signatures. The results showed that high levels of CRLF2 transcripts were associated with lower lung function in female subjects, and both male and female subjects with high CRLF2 transcript levels had fewer M2 macrophages and more activated mast cells and neutrophils. The study suggests that further investigation is needed to understand the mechanistic link between COPD progression, TSLP signaling, and activated mast cell abundance in smokers. [Extracted from the article]
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- 2024
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50. Evidence for the Regulation of Gynoecium Morphogenesis by ETTIN via Cell Wall Dynamics
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Andres-Robin, Amélie, Reymond, Mathieu C., Dupire, Antoine, Battu, Virginie, Dubrulle, Nelly, Mouille, Grégory, Lefebvre, Valérie, Pelloux, Jérôme, Boudaoud, Arezki, Traas, Jan, Scutt, Charles P., and Monéger, Françoise
- Published
- 2018
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