465 results on '"Mathews, Paul M."'
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2. Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During Aging
3. Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor
4. Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice
5. Macroautophagy: A Novel β-Amyloid Peptide-Generating Pathway Activated in Alzheimer's Disease
6. Dissociated Phenotypes in Presenilin Transgenic Mice Define Functionally Distinct γ-Secretases
7. In vivo Reduction of Amyloid-β by a Mutant Copper Transporter
8. Alleles at the Nicastrin Locus Modify Presenilin 1-Deficiency Phenotype
9. Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments
10. Cystatin C in aging and in Alzheimer’s disease
11. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF
12. Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice
13. Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice
14. Entorhinal cortical defects in Tg2576 mice are present as early as 2–4 months of age
15. Interactome Analyses of Mature γ-Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2
16. Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model
17. Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model
18. Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice
19. Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
20. Alzheimer's-Related Endosóme Dysfunction in down Syndrome Is Aß-Independent but Requires App and Is Reversed by BACE-1 Inhibition
21. Exogenous Induction of Cerebral β-Amyloidogenesis Is Governed by Agent and Host
22. Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice
23. The Pathway and Targeting Signal for Delivery of the Integral Membrane Glycoprotein LEP100 to Lysosomes
24. The in Vivo Brain Interactome of the Amyloid Precursor Protein
25. Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology: Accelerated Endocytosis Promotes Late Endocytic Defects
26. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
27. Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
28. Exogenous induction of cerebral [beta]-amyloidogenesis is governed by agent and host
29. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid β peptide
30. Macroautophagy--a novel [beta]-amyloid peptide-generating pathway activated in Alzheimer's disease
31. Dissociated phenotypes in presenilin transgenic mice define functionally distinct [alpha]-secretases
32. Tissue Processing Prior to Analysis of Alzheimer’s Disease Associated Proteins and Metabolites, Including Aβ
33. Aβ Measurement by Enzyme-Linked Immunosorbent Assay
34. Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of τ Protein Following Onset of Diabetes in NOD Mice
35. In vivo reduction of amyloid-[beta] by a mutant copper transporter
36. Brain Expression of Presenilins in Sporadic and Early-onset, Familial Alzheimer’s Disease
37. The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review
38. Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1
39. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimerʼs disease ameliorates amyloid pathologies and memory deficits
40. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
41. Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model
42. Elevated plasma cholesterol does not affect brain Aβ in mice lacking the low-density lipoprotein receptor
43. Alzheimerʼs presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo
44. Both the Sequence and Length of the C Terminus of PEN-2 Are Critical for Intermolecular Interactions and Function of Presenilin Complexes
45. Binding of cystatin C to Alzheimer’s amyloid β inhibits in vitro amyloid fibril formation
46. A Synthetic Peptide Blocking the Apolipoprotein E/β-Amyloid Binding Mitigates β-Amyloid Toxicity and Fibril Formation in Vitro and Reduces β-Amyloid Plaques in Transgenic Mice
47. Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology
48. Aging, gender and APOE isotype modulate metabolism of Alzheimerʼs Aβ peptides and F2-isoprostanes in the absence of detectable amyloid deposits
49. Co-expressed presenilin 1 NTF and CTF form functional γ-secretase complexes in cells devoid of full-length protein
50. Overexpression of Human Cystatin C in Transgenic Mice Does Not Affect Levels of Endogenous Brain Amyloid b Peptide
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