1. Amiodarone-associated Optic Neuropathy: A Critical Review
- Author
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Dennis P. West, Katrina Marie E Tulas, Rashmi Kapur, Joseph M. Purpura, Steven M. Belknap, Lisa Gaye A. Jones, Charles L. Bennett, Rod S. Passman, Athena T. Samaras, Lenworth N. Johnson, Mathew J. Fisher, Dustin B. Liebling, Beatrice J. Edwards, Dennis W. Raisch, and June M. McKoy
- Subjects
Pediatrics ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Amiodarone ,Blindness ,Asymptomatic ,Article ,Optic neuropathy ,Adverse Event Reporting System ,Optic Nerve Diseases ,medicine ,Humans ,Adverse effect ,business.industry ,General Medicine ,medicine.disease ,eye diseases ,Clinical trial ,Anesthesia ,Decreased Visual Acuity ,medicine.symptom ,business ,Anti-Arrhythmia Agents ,medicine.drug - Abstract
Although amiodarone is the most commonly prescribed anti-arrhythmic drug, its use is limited by serious toxicities, including optic neuropathy. Current reports of amiodarone-associated optic neuropathy identified from the Food and Drug Administration's Adverse Event Reporting System and published case reports were reviewed. A total of 296 reports were identified: 214 from the Adverse Event Reporting System, 59 from published case reports, and 23 from adverse events reports for patients enrolled in clinical trials. Mean duration of amiodarone therapy before vision loss was 9 months (range 1-84 months). Insidious onset of amiodarone-associated optic neuropathy (44%) was the most common presentation, and nearly one third were asymptomatic. Optic disk edema was present in 85% of cases. Following drug cessation, 58% had improved visual acuity, 21% were unchanged, and 21% had further decreased visual acuity. Legal blindness (
- Published
- 2012