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16 results on '"Mathes, Samuel"'

1. Mice with gene alterations in the GH and IGF family

Author

Qian, Yanrong, Berryman, Darlene E., Basu, Reetobrata, List, Edward O., Okada, Shigeru, Young, Jonathan A., Jensen, Elizabeth A., Bell, Stephen R. C., Kulkarni, Prateek, Duran-Ortiz, Silvana, Mora-Criollo, Patricia, Mathes, Samuel C., Brittain, Alison L., Buchman, Mat, Davis, Emily, Funk, Kevin R., Bogart, Jolie, Ibarra, Diego, Mendez-Gibson, Isaac, Slyby, Julie, Terry, Joseph, and Kopchick, John J.

Published
2022
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6. Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo

Author

Basu, Reetobrata, primary, Qian, Yanrong, additional, Mathes, Samuel, additional, Terry, Joseph, additional, Arnett, Nathan, additional, Riddell, Trent, additional, Stevens, Austin, additional, Funk, Kevin, additional, Bell, Stephen, additional, Bokal, Zac, additional, Batten, Courtney, additional, Smith, Cole, additional, Mendez-Gibson, Isaac, additional, Duran-Ortiz, Silvana, additional, Lach, Grace, additional, Mora-Criollo, Patricia Alexandra, additional, Kulkarni, Prateek, additional, Davis, Emily, additional, Teaford, Elizabeth, additional, Berryman, Darlene E., additional, List, Edward O., additional, Neggers, Sebastian, additional, and Kopchick, John J., additional

Published
2022
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8. Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan

Author

Duran‐Ortiz, Silvana, primary, List, Edward O., additional, Ikeno, Yuji, additional, Young, Jonathan, additional, Basu, Reetobrata, additional, Bell, Stephen, additional, McHugh, Todd, additional, Funk, Kevin, additional, Mathes, Samuel, additional, Qian, Yanrong, additional, Kulkarni, Prateek, additional, Yakar, Shoshana, additional, Berryman, Darlene E., additional, and Kopchick, John J., additional

Published
2021
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9. Mice with gene alterations in the GH and IGF family

Author

Qian, Yanrong, primary, Berryman, Darlene E., additional, Basu, Reetobrata, additional, List, Edward O., additional, Okada, Shigeru, additional, Young, Jonathan A., additional, Jensen, Elizabeth A., additional, Bell, Stephen R. C., additional, Kulkarni, Prateek, additional, Duran-Ortiz, Silvana, additional, Mora-Criollo, Patricia, additional, Mathes, Samuel C., additional, Brittain, Alison L., additional, Buchman, Mat, additional, Davis, Emily, additional, Funk, Kevin R., additional, Bogart, Jolie, additional, Ibarra, Diego, additional, Mendez-Gibson, Isaac, additional, Slyby, Julie, additional, Terry, Joseph, additional, and Kopchick, John J., additional

Published
2021
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10. Antagonism of Growth Hormone Receptor Suppresses Cancer Growth and Drug Resistance in Mice

Author

Qian, Yanrong, primary, Basu, Reetobrata, additional, Terry, Joseph, additional, Mathes, Samuel Casey, additional, Arnett, Nathan, additional, Smith, Cole, additional, Mendez-Gibson, Isaac, additional, Brittain, Alison, additional, Ortiz, Silvana Duran, additional, Kulkarni, Prateek, additional, Funk, Kevin Ray, additional, Bell, Stephen Robert Clyde, additional, List, Edward Owen, additional, Berryman, Darlene E, additional, and Kopchick, John Joseph, additional

Published
2021
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12. Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo

Author

Qian, Yanrong, primary, Basu, Reetobrata, additional, Mathes, Samuel C., additional, Arnett, Nathan A., additional, Duran-Ortiz, Silvana, additional, Funk, Kevin R., additional, Brittain, Alison L., additional, Kulkarni, Prateek, additional, Terry, Joseph C., additional, Davis, Emily, additional, Singerman, Jordyn T., additional, Henry, Brooke E., additional, List, Edward O., additional, Berryman, Darlene E., additional, and Kopchick, John J., additional

Published
2020
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13. The Effects of Elevated Water Conductivity on Larval Eastern Hellbender (Cryptobranchus a. alleganiensis) Survival, Development, Locomotor Performance, and Physiology

Author

Mathes, Samuel Casey

Subjects
Biology, Conservation, Ecology, Endocrinology, Freshwater Ecology, Molecular Biology, Morphology, Organismal Biology, Wildlife Conservation, Eastern Hellbender, conductivity, larvae, survival, growth, development, locomotor performance, physiology, morphology, salinity, stress, cortisol, lipid peroxidation, recruitment, salamander, amphibian
Abstract

Eastern Hellbenders (Crytobranchus a. alleganiensis) have suffered enigmatic, range- wide declines over the past decades. Persisting populations are skewed towards larger, older adults, suggesting that reduced recruitment is responsible for these declines, with degraded water quality, specifically elevated conductivity, implicated as a main contributor. Successful fertilization and the resilience of eggs under high conductivity conditions suggest deleterious effects during larval development. We experimentally assessed the effects of chronic exposure to elevated conductivity (1000 μS/cm) on wild Eastern Hellbender larvae hatched in a lab, as well as the effects of switching from low conductivity (100 μS/cm) to high, and vice versa, on Eastern Hellbenders during early larval development. We assessed mortality over 72 days post-hatching, with half of the larvae switched from their original conductivity treatments to the other over five days beginning at 33 days post-hatching. Chronic exposure to elevated conductivity resulted in significant mortality. Additionally, switching larvae from low conductivity to high resulted in increased mortality, while switching larvae from high conductivity to low increased survival. We also assessed larval morphology and swimming performance and found significant negative effects of chronic exposure to elevated conductivity on both body mass and multiple measures of morphology (length and width). We observed similar effects in animals switched from low conductivity to high, while switching animals from high conductivity to low resulted in only marginally increased mass and morphological measures, demonstrating their inability to compensate for initially depressed growth rates even after being returned to more optimal conditions. Despite altered size and morphology, elevated conductivity did not impact locomotor performance, though switching conductivities, regardless of direction, did result in increased burst distance. We measured whole-body cortisol at the end of the experiment as a measure of overall stress and found no differences across treatment groups, potentially due to the incomplete formation of the hypothalamic-pituitary-adrenal (HPA) axis during early larval development. We also measured lipid peroxidation, a marker of oxidative stress, and while not significant, we did observe increased lipid peroxidation in larvae chronically exposed to elevated conductivity. Furthermore, switching larvae from low conductivity to high similarly increased lipid peroxidation, while switching larvae from high conductivity to low resulted in decreased lipid peroxidation. In a preliminary analysis designed to explore the mechanisms underlying the inhibited growth we observed in larvae exposed to elevated conductivity, we leveraged transcriptomic information from the Chinese Giant Salamander (Andrias davidianus) to quantitatively evaluate the expression of growth-related genes in Eastern Hellbenders. While not significant, we observed consistently downregulated growth hormone (gh), growth hormone receptor (ghr), and prolactin receptor (prlr) messenger RNA (mRNA) transcripts in larvae chronically exposed to elevated conductivity. Additionally, these transcripts were consistently upregulated in larvae switched from high conductivity to low, and conversely, downregulated in those switched from low conductivity to high, suggestive of some effect of conductivity in modulating the expression of these growth conferring genes, possibly independent of hypothalamic control. The results of this study suggest that elevated conductivity has profound effects on larval Eastern Hellbenders and should be considered a critical metric relating persistence of self-sustaining populations to water quality.

Published
2024

14. Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma

Author

Basu, Reetobrata, primary, Kulkarni, Prateek, additional, Qian, Yanrong, additional, Walsh, Christopher, additional, Arora, Pranay, additional, Davis, Emily, additional, Duran-Ortiz, Silvana, additional, Funk, Kevin, additional, Ibarra, Diego, additional, Kruse, Colin, additional, Mathes, Samuel, additional, McHugh, Todd, additional, Brittain, Alison, additional, Berryman, Darlene E., additional, List, Edward O., additional, Okada, Shigeru, additional, and Kopchick, John J., additional

Published
2019
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15. SAT-LB054 Growth Hormone Receptor (GHR) Antagonism Suppresses Hepatocellular Carcinoma Growth in a Syngeneic Mouse Model

Author

Mathes, Samuel, primary, Qian, Yanrong, additional, Basu, Reetobrata, additional, Arnett, Nathan, additional, Duran Ortiz, Silvana, additional, Kruse, Colin, additional, Brittain, Alison, additional, Funk, Kevin, additional, Terry, Joseph, additional, Smith, Cole, additional, Bell, Stephen, additional, List, Edward, additional, Berryman, Darlene, additional, and Kopchick, John, additional

Published
2019
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16. MON-311 GH Action Upregulates ABC Transporters And EMT Markers In A Syngeneic Melanoma Mouse Model

Author

Qian, Yanrong, primary, Basu, Reetobrata, additional, Mathes, Samuel, additional, Arnett, Nathan, additional, Duran-Ortiz, Silvana, additional, Kruse, Colin, additional, Brittain, Alison, additional, Funk, Kevin, additional, Terry, Joseph, additional, Smith, Cole, additional, Henry, Brooke, additional, Bell, Stephen, additional, List, Edward, additional, Berryman, Darlene, additional, and Kopchick, John, additional

Published
2019
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