Search

Scoping review.To summarize information on the physiological effects of compression stockings (CS) in individuals with spinal cord injuries (SCI) and suggest areas for future research.We asked, "What are the physiological effects of CS use in individuals with SCI?" Original studies of patients with SCI regardless of sex and age that focused on SCI and CS were included. Five biomedical databases were searched. Studies were selected by three researchers in two stages, starting with an abstract and title screening and continuing with a full text review for application of the inclusion and exclusion criteria. A narrative synthesis was then performed.An initial search yielded 283 titles, of which five met the inclusion criteria and were subjected to the full text review. Among them, there were 78 individuals with SCI. The studies found that the use of CS at rest reduced deep vein thrombosis (DVT) and vascular capacitance but increased systolic blood pressure and norepinephrine level., three studies tested the use of CS During exercise; one found that time of the last lap in a standard court test was negatively affected; however, the greatest benefits were observed after exercises, such as reduced blood lactate level, improved autonomic function, and increased blood flow to the upper limbs.We conclude that future research should examine the physiological effects and relationship of CS with: (a) pharmacological interventions, (b) body position changes, (c) physical fitness level, (d) wheelchair use duration, (e) exercise-induced thermal stress, (f) thermal stress mitigation, and (g) edema reduction.

Objective: This protocol will describe the methods of a systematic review that examined studies on the relationship between consumption of ultra-processed foods and metabolic syndrome in adolescents. Methods: The searches will be carried out in the MEDLINE (via PubMed), EMBASE (via ScienceDirect), LILACS (via VHL), and Cochrane databases until March 2022. Observational (cohort, case-control and cross-sectional) and experimental (clinical trials) studies will be included, two researchers’ independents will use the Rayyan QCRI software for retrieval of the articles, in addition, the Mendeley software Reference Manager will be used for reference management. After reading them in ­full, the articles will be selected according to the eligibility criteria. Results: The synthesis of evidence data will be approached from the relationship of consumption of ultra-processed foods and metabolic syndrome in adolescents. Conclusion: Therefore, the importance of this review protocol is highlighted to compose the current evidence on the relationship between consumption of ultra-processed foods and the metabolic syndrome. Objetivo: Este protocolo describirá los métodos de una revisión sistemática que examinó estudios sobre la relación entre el consumo de alimentos ultraprocesados y el síndrome metabólico en adolescentes. Métodos: Se realizarán búsquedas en MEDLINE (vía PubMed), EMBASE (vía ScienceDirect), LILACS (vía BVS) y bases de datos Cochrane hasta marzo de 2022. Se incluirán estudios observacionales (cohorte, caso-control y transversales) y experimentales (ensayos clínicos), dos investigadores independientes utilizarán el software Rayyan QCRI para la recuperación de artículos, además, se utilizará el software Mendeley Reference Manager para la gestión de referencias. Después de leerlos en su totalidad, los artículos serán seleccionados de acuerdo con los criterios de elegibilidad. Resultados: Se abordará la síntesis de datos de evidencia a partir de la relación del consumo de alimentos ultraprocesados y el síndrome metabólico en adolescentes. Conclusión: Por lo tanto, se destaca la importancia de este protocolo de revisión para componer la evidencia actual sobre la relación entre el consumo de alimentos ultraprocesados y el síndrome metabólico. Objetivo: Este protocolo descreverá os métodos de uma revisão sistemática que examinaram estudos sobre a relação entre o consumo de alimentos ultraprocessados e síndrome metabólica em adolescentes. Métodos: As buscas serão realizadas nas bases de dados MEDLINE (via PubMed), EMBASE (via ScienceDirect), LILACS (via BVS), e Cochrane até março de 2022. Serão incluídos estudos observacionais (coorte, caso-controle e transversais) e experimentais (ensaios clínicos), dois pesquisadores independentes usarão o software Rayyan QCRI para recuperação dos artigos, além disso, o software Mendeley Reference Manager será usado para o gerenciamento de referência. Após a leitura na í­ntegra, os artigos serão selecionados de acordo com os critérios de elegibilidade. Resultados: A síntese dos dados das evidências será abordada a partir da relação do consumo de alimentos ultraprocessados e síndrome metabólica em adolescentes. Conclusão: Por conseguinte, realça-se a importância deste protocolo de revisão para compor as evidências atuais sobre a relação entre consumo de alimentos ultraprocessados e a síndrome metabólica.

Objective: The aim of this study was to identify the best energy dose of photobiomodulation therapy (PBMT) able to improve muscle performance and reduce fatigue during multiple-set knee extension e...

Objective: To investigate the effects of photobiomodulation therapy (PBMT) on resistance training volume and discomfort of well-trained adults. Background: PBMT has been used to attenuate fatigue i...

Purpose This study compared sex-related affective responses during resistance training performed to concentric failure. Methods The study was a non-randomized trial (quasi-experimental study). Well-trained young participants were allocated into two groups according to sex (Women, n = 7, 21.1 ± 6.0 years, 57.6 ± 5.0 kg; and Men, n = 7, 28.3 ± 5.7 years, 88.3 ± 11.4 kg). Participants visited the laboratory three times: 1) 12-repetition maximum; 2–3) resistance training to concentric failure sessions. Perceptual measures were assessed before, during, and immediately after the resistance training sessions. The following were assessed: a) rating of perceived exertion for effort (RPE-E) and discomfort (RPE-D), b) feeling scale, c) physical activity affect scale (PAAS), d) felt arousal scale, and e) physical activity enjoyment scale (PACES). Results High levels of RPE-E and RPE-D were reported without between-groups differences (p > 0.218). Women reported a reduction in the feeling scale (p = 0.001) whereas men did not (p > 0.680). Larger effect sizes were observed for women compared to men in the felt arousal scale and PAAS (negative affect and fatigue). Feeling scale and felt arousal scale data plotted in a circumplex model of affect indicated a transition to high-activation and unpleasant-affect only for the women. There was good reliability between results from sessions 1 and 2. Conclusions Training to concentric failure resulted in negative changes in affective perceptual responses only for women. This type of training should be used with caution since it may change the affect perception and reduce training adherence in women. Further studies are needed using larger sample sizes, different resistance-training exercises, and diverse training methods.

Objective This scoping review aimed to map evidence on açai supplementation combined with exercise in animal and/or human experimental studies. Methods The search considered six electronic databases and screening of relevant references. The selection process and data extraction were performed by two independent authors. The study characteristics, and AS (e.g., form, intervention time, amount ingested) and exercise (e.g., types, intensity, and duration) strategies were summarized, as well as their reported results. Results From an initial total of 342 studies identified; 11 (5 with animal and 6 with human models) were eligible. In animals, açai supplementation and exercise led to benefits in exercise tolerance and improvements in several hemodynamic parameters, as well as significant improvements in liver markers and glucose metabolism. In humans, açai supplementation indicated positive results in increasing exhaustion time to 90% of VO2max and increasing intensity at the anaerobic threshold. Conclusion We conclude that future research involving animals and humans should examine açai supplementation and exercise with (a) obesity models to test the effect of adiponectin on body composition with analysis of histological and histochemical parameters; (b) eccentric injury protocols with the incorporation of muscle quality variables to assess recovery; (c) chronic açai supplementation and strength training; (d) comparison of different forms of açai supplementation in exercise protocols. RESUMO Objetivo Esta revisão de escopo teve como objetivo mapear evidências sobre a suplementação com açaí combinada com exercícios físicos em estudos experimentais em animais e / ou humanos. Métodos A busca considerou seis bases de dados eletrônicas além da triagem de referências relevantes. O processo de seleção e extração de dados foi realizado por dois autores independentes. As características do estudo, estratégias de suplementação de açaí (forma, tempo de intervenção, e quantidade ingerida) e exercícios (tipos, intensidade e duração), seus resultados foram resumidos. Resultados Um total de 342 estudos foram inicialmente alcançados e somente 11 foram elegíveis (5 com animais e 6 com humanos). Em animais, a suplementação de açaí e os exercícios indicaram benefícios na tolerância ao exercício e melhorias em vários parâmetros hemodinâmicos, bem como melhorias significativas nos marcadores hepáticos e no metabolismo da glicose. Em humanos, a suplementação de açaí indicou resultados positivos no aumento do tempo de exaustão para 90% do VO2máx e no aumento da intensidade correspondente ao limiar anaeróbio. Conclusão Concluiu-se que pesquisas futuras envolvendo animais e humanos devem examinar a suplementação de açaí e exercícios com (a) modelos de obesidade para testar o efeito da adiponectina na composição corporal por meio de parâmetros histológicos e histoquímicos (b) protocolos de dano muscular excêntrico com incorporação de variáveis de qualidade muscular para avaliação da recuperação; (c) suplementação crônica de açaí e treinamento de força; (d) comparação das diferentes formas de suplementação de açaí em protocolos de exercícios.

The aim of the present study was to compare shoulder internal rotator and external rotator isokinetic parameters in concentric and eccentric contractions between volleyball players with and without a history of shoulder injury. Thirty male volleyball players participated of this study, divided into two groups: with a history of injury (WHI) in the dominant shoulder (11 athletes; age: 19.4 ± 3.6 years) and no history of injury (NHI) (19 athletes; age: 18.3 ± 2.9 years). The peak torque (PT) and concentric (Con) and eccentric (Ecc) PT angles in internal (IR) and external rotation (ER) at velocities of 60 and 180°/s were measured. The conventional (Con_ER:Con_IR), functional spiking (Ecc_ER:Con_IR), and cocking ratios (Ecc_IR:Con_ER) were calculated. No significant differences were found between groups for PT and PT angle, or for conventional, functional spiking, and cocking ratios. However, the spiking ratio was considered low (0.87) in the WHI group. Moreover, for the spiking ratio in the WHI group, PT at 60°/s occurred at different angles. We conclude that previous injury in shoulder did not affect the peak torque, as well as conventional, spiking or cocking ratio. However, the PT angles at 60°/s used to calculate the spiking ratio shifted due the prior injury.

The purpose of this study was to investigate the behavior of foot pronation at different percentages of peak velocity in 23 physically active men. An ergospirometric test was carried out with an initial velocity of 9kmh-1 and increments of 1kmh-1 until exhaustion. 2D kinematic analysis was performed in the posterior frontal plane at all velocities to identify the maximal angle of pronation (MAP) of the right leg. The analyses were performed between the initial periods (0%), 25%, 50%, 75%, and 100% (peak of velocity - PV). All comparisons of the PV phases with the MAP showed an increase in the angle of foot pronation, with the exception of between the start and 25% of PV. Only 4 (∼17%) subjects maintained MAP values within a normal range until PV was reached. Control of the volume and intensity of training, as well as the running technique is suggested and strengthening of the muscles responsible for stabilization of the foot pronation.

Considerando a importância da inserção de pessoas com deficiência no esporte, objetivamos identificar as barreiras e os facilitadores para a prática esportiva de pessoas com deficiência inseridas nos projetos de extensão da Universidade Federal de Santa Catarina (Brasil). Para determinar as barreiras e os facilitadores foi aplicado um questionário a 19 participantes. Usou-se o teste qui-quadrado para avaliar a associação entre barreiras e facilitadores (p0,05). Os indicadores estatisticamente associados como facilitadores para a prática esportiva de pessoas com deficiência incluem a simpatia e conhecimento profissional, apoio da família e amigos e a ausência de constrangimento à prática. A presença de lesões, o clima e a distância do local da prática foram associados como barreiras. Desse modo, propiciar um ambiente de elevado apoio social, estabelecer cuidados para evitar lesões físicas e oferecer programas esportivos descentralizados, na cidade, parecem ser medidas importantes para a efetiva participação de pessoas com deficiência no esporte.

Background: Intrathecal injection of voltage-sensitive calcium channel blocker peptide toxins exerts analgesic effect in several animal models of pain. Upon intrathecal administration, recombinant Phα1β exerts the same analgesic effects as the those of the native toxin. However, from a clinical perspective, the intrathecal administration limits the use of anesthetic drugs in patients. Therefore, this study aimed to investigate the possible antinociceptive effect of intravenous recombinant Phα1β in rat models of neuropathic pain, as well as its side effects on motor, cardiac (heart rate and blood pressure), and biochemical parameters. Methods: Male Wistar rats and male Balb-C mice were used in this study. Giotto Biotech® synthesized the recombinant version of Phα1β using Escherichia coli expression. In rats, neuropathic pain was induced by chronic constriction of the sciatic nerve and paclitaxel-induced acute and chronic pain. Mechanical sensitivity was evaluated using von Frey filaments. A radiotelemeter transmitter (TA11PA-C10; Data Sciences, St. Paul, MN, USA) was placed on the left carotid of mice for investigation of cardiovascular side effects. Locomotor activity data were evaluated using the open-field paradigm, and serum CKMB, TGO, TGP, LDH, lactate, creatinine, and urea levels were examined. Results: Intravenous administration of recombinant Phα1β toxin induced analgesia for up to 4 h, with ED50 of 0.02 (0.01-0.03) mg/kg, and reached the maximal effect (Emax = 100% antinociception) at a dose of 0.2 mg/kg. No significant changes were observed in any of the evaluated motor, cardiac or biochemical parameters. Conclusion: Our data suggest that intravenous administration of recombinant Phα1β may be feasible for drug-induced analgesia, without causing any severe side effects.

Rossato, M, Dellagrana, RA, Sakugawa, RL, Lazzari, CD, Baroni, BM, and Diefenthaeler, F. Time response of photobiomodulation therapy on muscular fatigue in humans. J Strength Cond Res 32(11): 3285-3293, 2018-The aim of this study was to identify the effects of 2 different time responses on fatigue of knee extensor. Sixteen male volunteers (26 ± 6.0 years, 81 ± 12 kg, and 181 ± 7.4 cm) participated in the study. Participants performed the same protocol in 5 sessions {control, placebo (placebo applied both 6 hours before and immediately before the test), 6 hours before + immediately before (photobiomodulation therapy [PBMT] applied both 6 hours before and immediately before the test), 6 hours before (PBMT applied 6 hours before and placebo applied immediately before the test), and immediately before (placebo applied 6 hours before and PBMT applied immediately before the test)}. Photobiomodulation therapy was applied on knee extensor (9 sites; 30 J per site). Maximal isometric voluntary contraction (MIVC) was assessed before and after an isokinetic fatigue (45 flexion-extension concentric at 180°·s), associated with electromyography (root mean square [RMS] and median of frequency [MF]). For MIVC, there was no treatment × time interaction for all variables. Time effect was observed for peak torque (PT), RMS, and MF. Treatment effect was verified for PT, and 6 hours before + immediately before condition presented higher PT during MIVCpre than control (p = 0.004) and placebo (p = 0.044). The immediately before presented higher PT values than control (p = 0.047). Regarding MIVCpost, the PT for 6 hours before + immediately before presented higher values than control (p = 0.001) and placebo (p = 0.004). Peak torque during MIVC (pre to post) was reduced in 6 hours before + immediately before treatment (26%) compared with control (33%), placebo (29%), and immediately before (32%). The application of PBMT 6 hours + immediately before and immediately before exercise protocol is able to reduce the fatigue.

There is a major, unmet need for the treatment of cancer pain, and new targets and medicines are required. The transient receptor potential ankyrin 1 (TRPA1), a cation channel expressed by nociceptors, is activated by oxidizing substances to mediate pain-like responses in models of inflammatory and neuropathic pain. As cancer is known to increase oxidative stress, the role of TRPA1 was evaluated in a mouse model of cancer pain. Fourteen days after injection of B16-F10 murine melanoma cells into the plantar region of the right hind paw, C57BL/6 mice exhibited mechanical and thermal allodynia and thigmotaxis behavior. While heat allodynia was partially reduced in TRP vanilloid 1 (TRPV1)-deficient mice, thigmotaxis behavior and mechanical and cold allodynia were absent in TRPA1-deficient mice. Deletion of TRPA1 or TRPV1 did not affect cancer growth. Intrathecal TRPA1 antisense oligonucleotides and two different TRPA1 antagonists (HC-030031 or A967079) transiently attenuated thigmotaxis behavior and mechanical and cold allodynia. A TRPV1 antagonist (capsazepine) attenuated solely heat allodynia. NADPH oxidase activity and hydrogen peroxide levels were increased in hind paw skin 14 days after cancer cell inoculation. The antioxidant, α-lipoic acid, attenuated mechanical and cold allodynia and thigmotaxis behavior, but not heat allodynia. Whereas TRPV1, via an oxidative stress-independent pathway, contributes partially to heat hypersensitivity, oxidative stress-dependent activation of TRPA1 plays a key role in mediating thigmotaxis behavior and mechanical and cold allodynia in a cancer pain model. TRPA1 antagonists might be beneficial in the treatment of cancer pain.

Photobiomodulation therapy (PBMT) applied prior to exercise may provide ergogenic effects by delaying the onset of fatigue. The Brazilian jiu-jitsu (BJJ) is a domain combat sport in which elbow flexors’ isometric contraction is commonly performed. This study was aimed at investigating the effects of PBMT on torque parameters in groups of BJJ athletes (n = 10) and physically active men (n = 10). The strength testing protocol was composed of elbow flexors’ maximal isometric voluntary contractions at 90°; treatment application (placebo or PBMT); fatigue protocol; and one elbow flexors’ maximal isometric voluntary contraction. Magnitude-based inference analyses were used to examine practical significance. BJJ athletes presented higher relative isometric peak torque values pre (ES = 0.92) and post (ES = 1.32) fatigue protocol than those observed in physically active men. Beneficial results were shown in the time to exhaustion (difference: 5.5 s, likely beneficial) and impulse during fatigue test (difference 271.1 N m s, possibly beneficial) for physically active men and in the impulse for BJJ athletes (difference 179.0 N m s, possibly beneficial) in favor of PBMT compared to placebo. The PBMT was efficient in delaying the onset of fatigue regardless of the individuals’ training level and could be suggested as an ergogenic factor to improve muscle performance.

Despite the evolution of runner performance in athletes with cerebral palsy (CP), little is known about neuromuscular parameters of sprinters from different classes, especially related to power output, muscular imbalances and asymmetry indexes in lower limbs. The aim of this study was to assess muscle power, muscular imbalance and asymmetry in sprinters with CP. Four male sprinters with CP (age, 18 to 27 years; body mass, 58.5 to 72.8 kg; height, 161.5 to 174 cm) classified as T38, T37, T36, T35 according to International Paralympic Committee functional classification, performed vertical counter movement jump and squat jump on force plate and isokinetic torque evaluations in both limbs. The concentric peak torque (PT) was measured at 60°/sec, 120°/sec and 180°/sec and PT eccentric at 60°/sec and 120°/sec. The asymmetry indexes, conventional and functional ratios were assessed. the results showed that athletes with more severe impairments (T35 and T36) showed worse performance to muscle power, more muscular imbalance and higher asymmetry in PT between limbs (> 10%). The exception was T37 athlete, who presented the better performance for all variables. it is concluded that CP athletes with more severe impairments showed lower jumping performance and torque production of knee extensors and flexors, they showed greater asymmetries between limbs. Finally, considering the results of T37 athlete, it seems that the athletic training for a longer period can reverse part of the neuromuscular impairments caused by CP.

The purpose of this study was to evaluate electromyography and kinematic parameters of the lower limbs using rebound boots (RB) and barefoot during a gym workout. This information can be helpful to practitioners to schedule rehabilitation and training programs. Ten women (25 ± 9 years) volunteered for the study; inclusion criteria were as follows: subjects must have experienced the use of RB and the analyzed exercises for at least 6 months, and have no previous injuries in the lower limbs. Seven exercises were performed for 30 s with the RB and subsequently barefoot. Data from muscle activation of vastus lateralis (VL), biceps femoris (BF), lateral gastrocnemius (LG) and 2D kinematics were collected. The use of RB triggered postural changes, characterized by greater hip extension (in 4 of the exercises) and knee extension (in 6 of the exercises) for the landing. RB reduced activation mainly in LG (in 6 of the exercise) while no changes were observed for VL (except in exercise 1) and BF. RB change kinematics and muscle activation suggesting changes in the way the legs absorb and transmit force during jumps. LG was the main muscle affected by the use of RB.

ObjectiveThe present study aimed to elucidate the mechanisms involved in MSU-induced IL-1β release in a rodent animal model of acute gout arthritis.MethodsPainful (mechanical and thermal hypersensitivity, ongoing pain and arthritis score) and inflammatory (oedema, plasma extravasation, cell infiltration and IL-1β release) parameters were assessed several hours after intra-articular injection of MSU (100 µg/articulation) in wild-type or knockout mice for Toll-like receptor 4 (TLR4), inducible nitric oxide synthase (iNOS), transient receptor potential (TRP) V1 and the IL-1 receptor (IL-1R). Also, wild-type animals were treated with clodronate, lipopolysaccharide from Rhodobacter sphaeroides (LPS-RS) (TLR4 antagonist), spleen tyrosine kinase (SYK) inhibitor (iSYK), aminoguanidine (AMG, an iNOS inhibitor) or SB366791 (TRPV1 antagonist). Nitrite/nitrate and IL-1β levels were measured on the synovial fluid of wild-type mice, 2 h after intra-articular MSU injections, or medium from macrophages stimulated for MSU (1000 μg) for 2 h.ResultsIntra-articular MSU injection caused robust nociception and severe inflammation from 2 up to 6 h after injection, which were prevented by the pre-treatment with clodronate, LPS-RS, iSYK, AMG and SB366791, or the genetic ablation of TLR4, iNOS, TRPV1 or IL-1R. MSU also increased nitrite/nitrate and IL-1β levels in the synovial fluid, which was prevented by clodronate, LPS-RS, iSYK and AMG, but not by SB366791. Similarly, MSU-stimulated peritoneal macrophages released nitric oxide, which was prevented by LPS-RS, iSYK and AMG, but not by SB366791, and released IL-1β, which was prevented by LPS-RS, iSYK, AMG and SB366791.ConclusionOur data indicate that MSU may activate TLR4, SYK, iNOS and TRPV1 to induce the release of IL-1β by macrophages, triggering nociception and inflammation during acute gout attack.

Although some studies showed a relationship between skin temperature and physical fitness, it is unclear if cycling experience could have an influence on thermoregulation. The aims of this study were to compare differences in skin temperature between Cyclists and Non-Cyclists and to assess the relationship between varying performance factors and skin temperature. Eleven Cyclists and eleven Non-Cyclists performed an incremental cycling test to exhaustion. Body composition, power output, oxygen consumption, heart rate, neuromuscular activation and skin temperature from Vastus Lateralis, Rectus Femoris, Biceps Femoris and Gastrocnemius Medialis were measured. Cyclists presented lower percentage body fat, greater peak power output and higher oxygen consumption (P 1.4), resulting in a higher heat production (P 1.1). Skin temperature was negatively correlated with body fat and positively correlated with peak power output and heat production (P

Ethnopharmacological relevance Vitex megapotamica (Spreng) Moldenke has been used in South American folk medicine to treat inflammatory diseases. However, the effects of V. megapotamica on animal models of nociception and depression have not been evaluated. Aim of the study This study investigated whether the crude leaf extract of V. megapotamica exhibits antinociceptive and antidepressant-like effects in a Freund’s adjuvant-induced chronic inflammation and depression model. Materials and methods Chronic inflammation was induced in rats by the intraplantar administration of complete Freund's adjuvant (CFA; 100 μl). The effect of oral crude extract of V. megapotamica (VmE; 3–30 mg/kg, p.o.) on nociception (thermal hyperalgesia, mechanical allodynia and arthritis score), inflammation (edema, myeloperoxidase activity), immobility (forced swimming test), locomotor activity (open field), gastrointestinal transit, hyperalgesia and naloxone-precipitated morphine withdrawal syndrome was evaluated. Naloxone (0.4 mg/kg, i.p.) was used to investigate the involvement of opioid system in the currently described effects of VmE. Results Crude extract caused antinociceptive/antidepressant-like effects in the CFA-induced chronic inflammation model, which was prevented by naloxone. The VmE extract (10 mg/kg, p.o.) did not alter the locomotor activity, gastrointestinal function and inflammatory parameters and did not cause hyperalgesia. Conclusion V. megapotamica induces opioid-dependent antinociception and antidepressant-like effect, without anti-inflammatory activity. The results support the use of VmE as analgesic and antidepressant.

Training with blood flow restriction could lead to an effect on skin temperature. Additionally, this effect could be higher in people with lower physical fitness level due to their lower capacity of heat loss. The aim of this preliminary study was therefore to evaluate the effects of training experience on the acute and chronic thermal skin responses after performing exercise with and without blood flow restriction. The study included ten men, of these, five were trained. All subjects performed tests and re-tests for maximum strength (1 repetition maximum) through unilateral leg extensions (right thigh at 45 ± 6.7 kg and left thigh at 45.5 ± 8.1 kg, p > 0.05). The protocol consisted of four sets to concentric failure, with one-minute rest intervals between sets at an intensity corresponding to 40% of 1 RM. There were 7-day intervals between experimental sessions (150 mmHg versus unrestricted flow restriction). The thermal images were made before the protocol (pre), immediately after the end of the series (post), and 24 h afterward (post 24 h). When comparing temperature variation (Δ exercise and Δ 24 h) between groups, it was observed that the trained participants showed a greater drop in temperature 24 h after exercise with 150 mmHg restriction (confidence interval: 95% of Δ 24 h [−0.2 to −0.9 °C]) compared to untrained subjects (p = 0.006 and ES > 1.5, confidence interval: 95% Δ 24 h [−0.1 to 0.6 °C].) In conclusion, this preliminary study showed that training experience interferes with the chronic cutaneous thermal temperature of the anterior thigh when strength training associated with blood flow restriction 150 mmHg was performed.

This study aimed to analyze neuromuscular and postural control in visually and nonvisually impaired judo athletes. Two judo athletes, one visually impaired and the other nonvisually impaired, participated in the study. The athletes presented similar demographic, anthropometric, and judo-technical characteristics. They performed maximal isometric handgrip strength (dominant and nondominant hand), vertical jumps (countermovement jump [CMJ] and squat jump [SJ]), and center of pressure assessment in three positions: neutral, anteroposterior, and judo combat base (Migi-shizentai). The main findings showed that the visually impaired athlete presented higher standing balance in the neutral and anteroposterior positions than non-visually impaired athlete (effect size [ES]>2.0). In the Migi-shizentai position, the disparity between both athletes was reduced, particularly in the displacement area (ES=0.52). The visually impaired athlete showed higher performance in the SJ but lesser performance in CMJ and handgrip strength tests than nonimpaired athlete (ES>2.0). We concluded that the postural stability was higher in the visually impaired athlete in the neutral and anteroposterior position, but similar to the nonvisually impaired athlete in Migi-shizentai position, possible due to the influence of judo practice. Moreover, the visually impaired athlete showed higher performance in the SJ than nonvisually impaired.

The purpose of this study was to investigate the influence of exercise order on volume load (VL) and myoelectric activation (EMG) during the bench press (BP), military press (MP) and close-grip bench press (CGBP) exercises executed with a barbell and Smith machine. Twelve men experienced in resistance training performed four different exercise sessions in randomised order. Each session consisted of four sets of a given exercise order: O1 = CGBP + MP + BP with barbell; O2 = inverse O1 with barbell, O3 = same O1 with Smith Machine; O4 = same O2 with Smith machine. EMG was assessed for the Clavicular head

Saddle height influences cycling performance and would be expected to influence cyclists physically, perceptually, and emotionally. We investigated how different saddle positions and cadences might affect cyclists’ torque, heart rate, rate of perceived exertion (RPE), and affective responses (Feeling scale). Nine male recreational cyclists underwent cycling sessions on different days under different conditions with a constant load. On Day 1, the saddle was at the reference position (109% of the distance from the pubic symphysis to the ground), and on Days 2 and 3, the saddle was in the “upward position” (reference + 2.5%) and “downward position” (reference − 2.5%) in random order. Each session lasted 30 minutes and was divided into three cadence-varied 10-minute stages without interruption: (a) freely chosen cadence (FCC), (b) FCC − 20%, and (c) FCC + 20%. We assessed all dependent measures at the end of each 10 minute stage. While there was no significant interaction (Saddle × Cadence) for any of the analyzed variables, torque values were higher at lower cadences in all saddle configurations, and the FCC + 20% cadence was associated with faster heart rate, higher RPE, and lower affect compared with FCC and FCC − 20% in all saddle positions. At all cadences, the saddle at “downward position” generated a higher RPE compared with “reference position” and “upward position.” The affective response was lower in the “downward position” compared with the “reference position.” Thus, while cyclists perceived the downward (versus reference) saddle position as greater exercise effort, they also associated it with unpleasant affect.

Although the intake of nonsteroidal anti-inflammatory drugs (NSAIDs) intake by athletes prevents soreness, little is known concerning their role in exercise performance. This study assessed the effects of ibuprofen intake on an exhaustive protocol test after 6 weeks of swimming training in rats. Animals were divided into sedentary and training groups. After training, animals were subdivided into two subsets: saline or ibuprofen. Afterwards, three repeated swimming bouts were performed by the groups. Ibuprofen (15 mg/kg) was administered once a day. Pain measurements were performed and inflammatory and oxidative stress parameters were assayed in cerebral cortex and gastrocnemius muscle. Training, ibuprofen administration, or both combined (P

Many types of cancer, including glioma, melanoma, non-small cell lung cancer (NSCLC), among others, are resistant to proapoptotic stimuli and thus poorly responsive to current therapies based on the induction of apoptosis in cancer cells. The current investigation describes the synthesis and anticancer evaluation of unique C12-Wittig derivatives of polygodial, a sesquiterpenoid dialdehyde isolated from Persicaria hydropiper (L.) Delabre. These compounds were found to undergo an unprecedented pyrrole formation with primary amines in a chemical model system, a reaction that could be relevant in the biological environment and lead to the pyrrolation of lysine residues in the target proteins. The anticancer evaluation of these compounds revealed their promising activity against cancer cells displaying various forms of drug resistance, including resistance to proapoptotic agents. Mechanistic studies indicated that compared to the parent polygodial, which displays fixative general cytotoxic action against human cells, the C12-Wittig derivatives exerted their antiproliferative action mainly through cytostatic effects explaining their activity against apoptosis-resistant cancer cells. The possibility for an intriguing covalent modification of proteins through a novel pyrrole formation reaction, as well as useful activities against drug resistant cancer cells, make the described polygodial-derived chemical scaffold an interesting new chemotype warranting thorough investigation., SCOPUS: ar.j, info:eu-repo/semantics/published

Successful pain control is a world health problem, which indicates an ever-growing need in the discovery of new molecules with improved analgesic activity and reduced side effects. The aim of this study was to describe the synthesis and biological activity of AC-MPF4, a new acetyl- and pyrazole-containing molecule derivate from MPF4. Firstly, we evaluated the analgesic and anti-edematogenic effect of AC-MPF4 in the carrageenan test. AC-MPF4 presented similar analgesic properties to MPF4 (opioid drug) and acetylsalicylic acid (ASA-a non-steroidal anti-inflammatory drug) (maximal effect of 85.4±10.9%, 62.0±11.0% and 95.0±10.4% of allodynia reduction, respectively). Regarding anti-edematogenic properties, AC-MPF4 presented similar results to ASA, while MPF4 presented no effect (maximal effect of 42.2±8.3% and 46.1±5.1% in paw thickness reduction, respectively). Remarkably, Naloxone fully prevented the analgesic effect of MPF4 and partially prevented the analgesic effect of AC-MPF4. However, neither ASA nor the anti-edematogenic activity was affected by Naloxone. The gastrointestinal motility and gastric mucosa integrity, which are parameters affected by opioid and NSAID drugs, respectively, were also evaluated. Neither of these parameters showed alterations induced by AC-MPF4, whereas ASA induced gastric ulceration (10 fold higher), and MPF4 decreased gastrointestinal motility (62.0±7.7%). Together, these data indicate that AC-MPF4 presents good analgesic and anti-edematogenic effects with no detectable side effects. AC-MPF4 may be considered a good prototype for the development of new analgesic/anti-inflammatory drugs.

The clinical use of paclitaxel as a chemotherapeutic agent is limited by the severe acute and chronic hypersensitivity caused when it is administered via intraperitoneal or intravenous routes. Thus far, evidence has suggested that transient receptor potential vanilloid-1 (TRPV1) has a key role in the chronic neuropathy induced by paclitaxel. Despite this, the role of TRPV1 in paclitaxel -related acute nociception, especially the development of visceral nociception, has not been evaluated. Thus, the goal of this study was to evaluate the participation of TRPV1 in a model of acute nociception induced by paclitaxel in rats and mice. A single intraperitoneal (i.p.) paclitaxel administration (1 mg/kg, i.p.) produced an immediate visceral nociception response 1 h after administration, caused mechanical and heat hypersensitivity, and diminished burrowing behaviour 24 h after administration. These nociceptive responses were reduced by SB-366791 treatment (0.5 mg/kg, i.p., a TRPV1 antagonist). In addition, TRPV1-positive sensory fibre ablation (using resiniferatoxin, 200 µg/kg, s.c.) reduced visceral nociception and mechanical or heat hypersensitivity caused by paclitaxel injection. Similarly, TRPV1 deficient mice showed a pronounced reduction in mechanical allodynia to paclitaxel acute injection and did not develop heat hypersensitivity. Moreover, 24 h after its injection, paclitaxel induced chemical hypersensitivity to capsaicin (a TRPV1 agonist, 0.01 nmol/site) and increased TRPV1 immunoreactivity in the dorsal root ganglion and sciatic nerve. In conclusion, TRPV1 is involved in mechanical and heat hypersensitivity and spontaneous-pain behaviour induced 24 h after a single paclitaxel injection. This receptor is also involved in visceral nociception induced immediately after paclitaxel administration.

Sympathetic fibres maintain some forms of neuropathic pain, but the underlying mechanisms are poorly understood. Therefore, this study investigated the possible involvement of transient receptor potential ankyrin 1 (TRPA1) and the role of the sympathetic nervous system (involved in sympathetically maintained neuropathic pain) in a model of neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) in mice. Systemic injection of the selective TRPA1 antagonist HC-030031 reversed the mechanical and cold allodynia that was induced by sciatic nerve chronic constriction injury (CCI). Nerve injury also sensitised mice to nociception, which was induced by the intraplantar injection of a low dose of the TRPA1 agonist allyl isothiocyanate without changing TRPA1 immunoreactivity in the injected paw. Furthermore, chemical sympathectomy produced by guanethidine largely prevented CCI-induced mechanical and cold allodynia. CCI also induced a norepinephrine-triggered nociception that was inhibited by an α-adrenoceptor antagonist, norepinephrine transporter block and monoamine oxidase inhibition. Finally, the peripheral injection of HC-030031 also largely reduced CCI-induced norepinephrine nociception and mechanical or cold allodynia. Taken together, the present findings reveal a critical role of TRPA1 in mechanical and cold hypersensitivity and norepinephrine hypersensitivity following nerve injury. Finally, our results suggest that TRPA1 antagonism may be useful to treat patients who present sympathetically maintained neuropathic pain.

The purpose of this study was to verify the photobiomodulation therapy (PBMT) effects with different doses on neuromuscular economy during submaximal running tests. Eighteen male recreational runners participate in a randomized, double-blind, and placebo-controlled trial, which each participant was submitted to the same testing protocol in five conditions: control, placebo, and PBMT with doses of 15, 30, and 60 J per site (14 sites in each lower limb). The submaximal running was performed at 8 and 9 km h−1 during 5 min for each velocity. Muscle activation of the vastus lateralis (VL), vastus medialis (VM), rectus femoris (RF), biceps femoris (BF), and gastrocnemius lateralis (GL) was collected during the last minute of each running test. The root mean square (RMS) was normalized by maximal isometric voluntary contraction (MIVC) performed a priori in an isokinetic dynamometer. The RMS sum of all muscles (RMSLEG) was considered as main neuromuscular economy parameter. PBMT with doses of 15, 30, and 60 J per site [33 diodes = 5 lasers (850 nm), 12 LEDs (670 nm), 8 LEDs (880 nm), and 8 LEDs (950 nm)] or placebo applications occurred before running tests. For the statistical analysis, the effect size was calculated. Moreover, a qualitative inference was used to determine the magnitude of differences between groups. Peak torque and RMS during MIVCs showed small effect sizes. According to magnitude-based inference, PBMT with dose of 15 J per site showed possibly and likely beneficial effects on neuromuscular economy during running at 8 and 9 km h−1, respectively. On other hand, PBMT with doses of 30 and 60 J per site showed possible beneficial effects only during running at 9 km h−1. We concluded that PBMT improve neuromuscular economy and the best PBMT dose was 15 J per site (total dose of 420 J).

O objetivo do estudo foi comparar por genero as variaveis dos aspectos relacionados a percepcao de saude e comportamento preventivo em escolares da rede publica cursando o ensino medio na cidade de Manaus. Foram selecionados 894 escolares (15-19 anos) sendo 393 homens e 501 mulheres. As informacoes foram obtidas por meio de questionario desenvolvido e validado para adolescentes. Observou-se que os homens se consideram mais saudaveis que as mulheres. Nao houve diferenca significativa entre os generos quanto a qualidade de sono. As mulheres apresentaram maior nivel de estresse sendo a principal fonte “problemas de relacionamento” (57,9%). Nos ultimos 12 meses 9,4% dos homens e 9% das mulheres na “maioria das vezes” sentiram-se sozinhos. A maioria das mulheres nunca tiveram relacoes (46,1%) quando comparadas aos homens (25,4%). O indice de homens que “sempre” fazem uso de preservativo foi maior (41%) com relacao as mulheres (29,3%). Os valores para ambos os generos que nunca se envolveram com briga foram maiores que 50%. Desta maneira torna-se importante a verificacao desses indicadores de saude, assim como suas percepcoes e comportamentos, pois estes quando cultivados de maneira positiva durante a adolescencia contribuem para uma afirmacao da qualidade de vida, porem quando nao cultivados podem afetar negativamente a saude.