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3 results on '"Mateus Cardoso Colares"'

1. The effectiveness of treadmill and swimming exercise in an animal model of osteoarthritis

Author

Leandro Almeida da Silva, Anand Thirupathi, Mateus Cardoso Colares, Daniela Pacheco dos Santos Haupenthal, Ligia Milanez Venturini, Maria Eduarda Anastácio Borges Corrêa, Gustavo de Bem Silveira, Alessandro Haupenthal, Fernando Russo Costa do Bomfim, Thiago Antônio Moretti de Andrade, Yaodong Gu, and Paulo Cesar Lock Silveira

Subjects
osteoarthritis, physical exercise, inflammation, oxidative stress, histology, Physiology, QP1-981
Abstract

Introduction: Osteoarthritis (OA) is considered an inflammatory and degenerative joint disease, characterized by loss of hyaline joint cartilage and adjacent bone remodeling with the formation of osteophytes, accompanied by various degrees of functional limitation and reduction in the quality of life of individuals. The objective of this work was to investigate the effects of treatment with physical exercise on the treadmill and swimming in an animal model of osteoarthritis.Methods: Forty-eight male Wistar rats were divided (n=12 per group): Sham (S); Osteoarthritis (OA); Osteoarthritis + Treadmill (OA + T); Osteoarthritis + Swimming (OA + S). The mechanical model of OA was induced by median meniscectomy. Thirty days later, the animals started the physical exercise protocols. Both protocols were performed at moderate intensity. Forty-eight hours after the end of the exercise protocols, all animals were anesthetized and euthanized for histological, molecular, and biochemical parameters analysis.Results: Physical exercise performed on a treadmill was more effective in attenuating the action of pro-inflammatory cytokines (IFN-γ, TNF-α, IL1-β, and IL6) and positively regulating anti-inflammatories such as IL4, IL10, and TGF-β in relation to other groups.Discussion: In addition to maintaining a more balanced oxi-reductive environment within the joint, treadmill exercise provided a more satisfactory morphological outcome regarding the number of chondrocytes in the histological evaluation. As an outcome, better results were found in groups submitted to exercise, mostly treadmill exercise.

Published
2023
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2. Intra-articular Treatment with Triamcinolone Hexacetonide Associated with Gold Nanoparticles Reduces Cartilage Degeneration in an Animal Model of Osteoarthritis

Author

Daniela, Pacheco Dos Santos Haupenthal, Marcus, Barg Resmini, Leandro, Almeida Da Silva, Mateus, Cardoso Colares, Laura, de Roch Casagrande, Ligia, Milanez Venturini, Thiago Antônio, Moretti de Andrade, Fernando, Russo Costa do Bomfim, Anand, Thirupathi, Paulo, Emilio Feuser, Felipe, Dal Pizzol, and Paulo Cesar, Lock Silveira

Subjects
Pharmacology, Clinical Biochemistry, Drug Discovery, Molecular Medicine
Abstract

Introduction: The association between triamcinolone hexacetonide (TH) and gold nano-particles (GNPs) represents a promising treatment due to the potential anti-inflammatory and anti-oxidant effects of these compounds. In this study, we evaluated the effects of intra-articular treat-ment of TH associated with GNPs in a mechanical model of osteoarthritis (OA). Methods: Fifty Wistar rats were divided into five groups: Sham; OA; OA+TH; OA+GNPs; OA+TH-GNPs. Both applications were performed 30 and 60 days after the model was induced. Af-ter 30 days of the last application, the animals were euthanized. Results: Only the combined treatment with TH and GNPs promoted a reduction in pro-inflammatory cytokines and an increase in anti-inflammatory cytokines. The OA+TH-GNPs group obtained a significant reduction in the production of oxidants and oxidative damage markers while an increase in antioxidants. Histologically, all treated groups showed results of a significant increase in cartilage thickness and chondrocyte count, the OA+TH-GNPs group had similar behavior to the group without osteoarthritis, with significantly smaller amounts of chondrocytes than the OA group. Conclusion: The intra-articular use of TH associated with GNPs may be able to prevent the pro-gression of the pathology and minimize joint degradation.

Published
2023

3. INDICADORES DE QUALIDADE DE VIDA EM PROFESSORES: UMA REVISÃO SISTEMÁTICA DE ESTUDOS DESCRITIVOS

Author

Valter Cordeiro Barbosa Filho, Fabiana Cristina Scherer, Mateus Cardoso Colares, Adair da Silva Lopes, and Anelise Bavaresco

Subjects
Escola, Qualidade de vida, Educação Física, Saúde, Docentes
Abstract

O objetivo foi sistematizar informações sobre indicadores de qualidade de vida (QV) de professores do Ensino Fundamental e Médio. A busca foi realizada em cinco bases de dados e nas referências dos artigos. Dos 14 estudos resultantes, 57% eram com professores de Educação Básica e 43% de Educação Física. A maioria dos estudos ressaltou insatisfação com a remuneração, condições de trabalho inconvenientes, escassez de tempo, ambiente desfavorável e problemas vocais. Conclui-se que a estrutura física, salários e sistemas organizacionais se destacam na literatura como aspectos negativamente associados à QV de professores. Estas evidências servem para nortear políticas de gestão escolar voltadas à melhoria da QV no trabalho e saúde em profissionais do âmbito escolar.

Published
2015

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