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4 results on '"Matassoli, Flavio Lemos"'

1. Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines

Author

Bezerra, Bruno Braz, primary, Silva, Gustavo Peixoto Duarte da, additional, Coelho, Sharton Vinicius Antunes, additional, Correa, Isadora Alonso, additional, Souza, Marcos Romario Matos de, additional, Macedo, Keylla Vitória Gomes, additional, Matos, Bruna Machado, additional, Tanuri, Amilcar, additional, Matassoli, Flavio Lemos, additional, Costa, Luciana Jesus da, additional, Hildreth, James E.K., additional, and Arruda, Luciana Barros de, additional

Published
2022
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2. Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil

Author

Pinheiro, Tauyne Menegaldo, primary, Mota, Mânlio Tasso de Oliveira, additional, Watanabe, Aripuanã Sakurada Aranha, additional, Biselli-Périco, Joice Matos, additional, Drumond, Betânia Paiva, additional, Ribeiro, Milene Rocha, additional, Vedovello, Danila, additional, Araújo, João Pessoa, additional, Pimenta, Paulo Filemon Paolucci, additional, Chaves, Bárbara Aparecida, additional, Silva, Mayara Marques Carneiro da, additional, Batista, Izabella Cristina Andrade, additional, Papa, Michelle Premazzi, additional, Meuren, Lana Monteiro, additional, Lucas, Carolina Gonçalves de Oliveira, additional, Matassoli, Flavio Lemos, additional, Gil, Laura Helena Vega Gonzales, additional, Bozzi, Adriana, additional, Calzavara-Silva, Carlos Eduardo, additional, Arruda, Luciana Barros de, additional, Souza, Danielle da Glória de, additional, Teixeira, Mauro Martins, additional, Vasilakis, Nikos, additional, and Nogueira, Maurício Lacerda, additional

Published
2018
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3. Zika Virus Infects, Activates, and Crosses Brain Microvascular Endothelial Cells, without Barrier Disruption.

Author

Papa, Michelle P., Meuren, Lana M., Coelho, Sharton V. A., de Oliveira Lucas, Carolina G., Mustafá, Yasmin M., Matassoli, Flavio Lemos, Silveira, Paola P., Frost, Paula S., Pezzuto, Paula, Ribeiro, Milene R., Tanuri, Amilcar, Nogueira, Mauricio L., Campanati, Loraine, Bozza, Marcelo T., Neto, Heitor A. Paula, Pimentel-Coelho, Pedro M., Figueiredo, Claudia P., de Aguiar, Renato S., and de Arruda, Luciana B.

Subjects
ZIKA virus infections, ENDOTHELIAL cells, THERAPEUTICS
Abstract

Zika virus (ZIKV) has been associated to central nervous system (CNS) harm, and virus was detected in the brain and cerebrospinal fluids of microcephaly and meningoencephalitis cases. However, the mechanism by which the virus reaches the CNS is unclear. Here, we addressed the effects of ZIKV replication in human brain microvascular endothelial cells (HBMECs), as an in vitro model of blood brain barrier (BBB), and evaluated virus extravasation and BBB integrity in an in vivo mouse experimental model. HBMECs were productively infected by African and Brazilian ZIKV strains (ZIKVMR766 and ZIKVPE243), which induce increased production of type I and type III IFN, inflammatory cytokines and chemokines. Infection with ZIKVMR766 promoted earlier cellular death, in comparison to ZIKVPE243, but infection with either strain did not result in enhanced endothelial permeability. Despite the maintenance of endothelial integrity, infectious virus particles crossed the monolayer by endocytosis/exocytosis-dependent replication pathway or by transcytosis. Remarkably, both viruses' strains infected IFNAR deficient mice, with high viral load being detected in the brains, without BBB disruption, which was only detected at later time points after infection. These data suggest that ZIKV infects and activates endothelial cells, and might reach the CNS through basolateral release, transcytosis or transinfection processes. These findings further improve the current knowledge regarding ZIKV dissemination pathways. [ABSTRACT FROM AUTHOR]

Published
2017
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4. Regulation of HIV-Gag Expression and Targeting to the Endolysosomal/Secretory Pathway by the Luminal Domain of Lysosomal-Associated Membrane Protein (LAMP-1) Enhance Gag-Specific Immune Response

Author

Godinho, Rodrigo Maciel da Costa, primary, Matassoli, Flavio Lemos, additional, Lucas, Carolina Gonçalves de Oliveira, additional, Rigato, Paula Ordonhez, additional, Gonçalves, Jorge Luiz Santos, additional, Sato, Maria Notomi, additional, Maciel, Milton, additional, Peçanha, Ligia Maria Torres, additional, August, J. Thomas, additional, de Azevedo Marques, Ernesto Torres, additional, and de Arruda, Luciana Barros, additional

Published
2014
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