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11 results on '"Mataca, Ema"'

2. Correlation between Autofluorescence Intensity and Histopathological Features in Non-Melanoma Skin Cancer: An Ex Vivo Study

Author

Giovannacci, Ilaria, primary, Meleti, Marco, additional, Garbarino, Federico, additional, Cesinaro, Anna Maria, additional, Mataca, Ema, additional, Pedrazzi, Giuseppe, additional, Reggiani, Camilla, additional, Paganelli, Alessia, additional, Truzzi, Arianna, additional, Elia, Federica, additional, Giacomelli, Luca, additional, and Magnoni, Cristina, additional

Published
2021
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10. Metabolomic Analysis of Actinic Keratosis and SCC Suggests a Grade-Independent Model of Squamous Cancerization

Author

Valeria Righi, Camilla Reggiani, Elisabetta Tarentini, Adele Mucci, Alessia Paganelli, Anna Maria Cesinaro, Ema Mataca, Shaniko Kaleci, Barbara Ferrari, Marco Meleti, Cristina Magnoni, Righi, Valeria, Reggiani, Camilla, Tarentini, Elisabetta, Mucci, Adele, Paganelli, Alessia, Cesinaro, Anna Maria, Mataca, Ema, Kaleci, Shaniko, Ferrari, Barbara, Meleti, Marco, and Magnoni, Cristina

Subjects
actinic keratosi, squamous cell carcinoma, human skin metabolomic, Histology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, food and beverages, biomarkers, Human skin metabolomics, metabolomic NMR profiling, female genital diseases and pregnancy complications, Article, Actinic keratosis, Biomarkers, Metabolomic NMR profiling, Squamous cell carcinoma, histology, stomatognathic diseases, actinic keratosis, biomarker, neoplasms, RC254-282, human skin metabolomics
Abstract

Background—Actinic keratoses (AKs) are the most common sun-induced precancerous lesions that can progress to squamocellular carcinoma (SCC). Recently, the grade-independent association between AKs and SCC has been suggested, however, the molecular bases of this potential association have not been investigated. This study has assessed the metabolomic fingerprint of AK I, AK II, AK III and SCC using high resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy in order to evaluate the hypothesis of grade-independent association between AK and SCC. Association between AKs and SCCs has also been evaluated by histopathology. Methods—Metabolomic data were obtained through HR-MAS NMR spectroscopy. The whole spectral profiles were analyzed through multivariate statistical analysis using MetaboAnalyst 5.0. Histologic examination was performed on sections stained with hematoxylin and eosin, statistical analysis was performed using STATA software version 14. Results—A group of 35 patients affected by AKs and/or SCCs and 10 healthy controls were enrolled for metabolomics analysis. Histopathological analysis was conducted on 170 specimens of SCCs and AKs (including the ones that underwent metabolomic analysis). SCCs and AK I were found to be significantly associated in terms of the content of some metabolites. Moreover, in the logistic regression model, the presence of parakeratosis in AKs appeared to be less frequently associated with SCCs, while AKs with hypertrophy had a two-fold higher risk of being associated with SCC. Conclusions—Our findings, derived from metabolomics and histopathological data, support the notion that AK I are different from healthy skin and share some different features with SCCs. This may further support the expanding notion that all AKs should be treated independently from their clinical appearance or histological grade because they may be associated with SCC.

Published
2021

11. The Jellyfish Sign: A New Sonographic Cervical Marker to Predict Maternal Morbidity in Abnormally Invasive Placenta Previa.

Author

Bertucci E, Sileo FG, Grandi G, Fenu V, Cani C, Mancini L, Mataca E, and Facchinetti F

Subjects
Cesarean Section, Female, Humans, Pregnancy, Retrospective Studies, Cervix Uteri pathology, Placenta Accreta diagnosis, Placenta Previa diagnosis
Abstract

Purpose:  To investigate the value of a new cervical sonographic sign, called the jellyfish sign (JS), for predicting the risk of maternal morbidity in cases of abnormally invasive placenta (AIP) previa totalis., Materials and Methods:  Retrospective evaluation of transvaginal (TV) and transabdominal (TA) scans performed in all singleton pregnancies with placenta previa totalis. JS, i. e. the absence of the normal linear demarcation between the placenta previa and the cervix, was evaluated by TV scans. The presence/severity of AIP and outcomes of maternal morbidity were related to this sign., Results:  JS was noted in 8/39 (20.5 %) patients. The two analyzed groups, i. e. with and without JS, were similar. The specificity of JS in AIP diagnosis, histological findings of accreta/increta/percreta, need for caesarean hysterectomy or blood loss > 2000 ml ranges between 92 % and 96.2 %, with the PPV and NPV ranging between 71.4 % and 85.7 % and 61.3 % and 80.6 %, respectively. The JS group had a significant increase in blood loss (ml) (p = 0.003), transfusions (%) (p = 0.016), red blood cells (p = 0.002) and plasma (p = 0.002), admission to an postoperative intensive care unit (ICU) (%) (p = 0.002), hospitalization length (p < 0.001) and the need of cesarean hysterectomy (%) (p < 0.001). JS was independently correlated to cesarean hysterectomy (OR 25.6; 95 % CI 2.0:322.3, p = 0.012) and blood loss > 2000 ml (OR 16.6; 95 % CI 1.5:180.1, p = 0.021) also in a logistic regression model., Conclusion:  JS is useful in predicting the increase in maternal morbidity: massive transfusion, admission to the ICU and cesarean hysterectomy related to intraoperative bleeding in patients with a previa AIP., Competing Interests: Disclosure The authors report no conflicts of interest in this work., (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2019
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