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2. Allogeneic hematopoietic cell transplantation for acute myeloid leukemia with BCR::ABL1 fusion

Author

Shohei Mizuno, Akiyoshi Takami, Koji Kawamura, Kaito Harada, Masuko Masayoshi, Shingo Yano, Ayumu Ito, Yukiyasu Ozawa, Fumihiko Ouchi, Takashi Ashida, Yuichiro Nawa, Tatsuo Ichinohe, Takahiro Fukuda, Yoshiko Atsuta, and Masamitsu Yanada

Subjects
acute myeloid leukemia, allogeneic hematopoietic cell transplantation, BCR::ABL1, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Abstract BCR::ABL1 fusion is found in

Published
2024
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4. Incidence and predictors of recurrent sick leave in survivors who returned to work after allogeneic hematopoietic cell transplantation

Author

Kurosawa, Saiko, Yamaguchi, Takuhiro, Mori, Ayako, Matsuura, Tomoko, Masuko, Masayoshi, Murata, Makoto, Tashiro, Haruko, Kako, Shinichi, Satake, Atsushi, Hagihara, Maki, Ota, Shuichi, Saito, Takeshi, Kagawa, Kumiko, Matsuo, Yayoi, Itonaga, Hidehiro, Uoshima, Nobuhiko, Yamaguchi, Hiroki, Naito, Kensuke, Takahashi, Miyako, and Fukuda, Takahiro

Published
2023
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5. Reduced chondroitin sulfate content prevents diabetic neuropathy through transforming growth factor-β signaling suppression

Author

Ishiguro, Hajime, Ushiki, Takashi, Honda, Atsuko, Yoshimatsu, Yasuhiro, Ohashi, Riuko, Okuda, Shujiro, Kawasaki, Asami, Cho, Kaori, Tamura, Suguru, Suwabe, Tatsuya, Katagiri, Takayuki, Ling, Yiwei, Iijima, Atsuhiko, Mikami, Tadahisa, Kitagawa, Hiroshi, Uemura, Akiyoshi, Sango, Kazunori, Masuko, Masayoshi, Igarashi, Michihiro, and Sone, Hirohito

Published
2024
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8. Salvage single-unit unrelated cord blood transplantation for graft failure following initial allogeneic transplantation in adult acute myeloid leukemia: trends in outcomes over the past 20 years

Author

Konuma, Takaaki, Harada, Kaito, Kondo, Tadakazu, Masuko, Masayoshi, Uchida, Naoyuki, Yano, Shingo, Kawakita, Toshiro, Onizuka, Makoto, Ota, Shuichi, Sakaida, Emiko, Miyakoshi, Shigesaburo, Ozawa, Yukiyasu, Imamura, Yutaka, Kimura, Takafumi, Kanda, Yoshinobu, Fukuda, Takahiro, Atsuta, Yoshiko, and Yanada, Masamitsu

Published
2022
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12. Single cord blood transplantation for acute myeloid leukemia patients aged 60 years or older: a retrospective study in Japan

Author

Isobe, Masamichi, Konuma, Takaaki, Masuko, Masayoshi, Uchida, Naoyuki, Miyakoshi, Shigesaburo, Sugio, Yasuhiro, Yoshida, Shuro, Tanaka, Masatsugu, Matsuhashi, Yoshiko, Hattori, Norimichi, Onizuka, Makoto, Aotsuka, Nobuyuki, Kouzai, Yasushi, Wake, Atsushi, Kimura, Takafumi, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Yanada, Masamitsu

Published
2021
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14. A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin

Author

Nishida, Tetsuya, Kobayashi, Takeshi, Sawa, Masashi, Masuda, Shinichi, Shibasaki, Yasuhiko, Goto, Tatsunori, Fukuhara, Noriko, Fujii, Nobuharu, Ikegame, Kazuhiro, Sugita, Junichi, Ikeda, Takashi, Kuwatsuka, Yachiyo, Suzuki, Ritsuro, Najima, Yuho, Doki, Noriko, Kato, Tomonori, Inagaki, Yuichiro, Utsu, Yoshikazu, Aotsuka, Nobuyuki, Masuko, Masayoshi, Terakura, Seitaro, Onishi, Yasushi, Maeda, Yoshinobu, Okada, Masaya, Teshima, Takanori, and Murata, Makoto

Published
2021
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15. Time-Varying Effects of Graft Type on Outcomes for Patients with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation

Author

Yanada, Masamitsu, Konuma, Takaaki, Yamasaki, Satoshi, Kuwatsuka, Yachiyo, Masuko, Masayoshi, Tanaka, Masatsugu, Ozawa, Yukiyasu, Toya, Takashi, Fukuda, Takahiro, Ota, Shuichi, Sawa, Masashi, Uchida, Naoyuki, Nakamae, Hirohisa, Eto, Tetsuya, Kanda, Junya, Takanashi, Minoko, Kanda, Yoshinobu, Atsuta, Yoshiko, and Yano, Shingo

Published
2020
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17. Using a machine learning algorithm to predict acute graft-versus-host disease following allogeneic transplantation

Author

Arai, Yasuyuki, Kondo, Tadakazu, Fuse, Kyoko, Shibasaki, Yasuhiko, Masuko, Masayoshi, Sugita, Junichi, Teshima, Takanori, Uchida, Naoyuki, Fukuda, Takahiro, Kakihana, Kazuhiko, Ozawa, Yukiyasu, Eto, Tetsuya, Tanaka, Masatsugu, Ikegame, Kazuhiro, Mori, Takehiko, Iwato, Koji, Ichinohe, Tatsuo, Kanda, Yoshinobu, and Atsuta, Yoshiko

Published
2019
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18. Clinical practice recommendations for the diagnosis and management of human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation: the Japan Society for Hematopoietic Cell Transplantation

Author

Ogata, Masao, Uchida, Naoyuki, Fukuda, Takahiro, Ikegame, Kazuhiro, Kamimura, Tomohiko, Onizuka, Makoto, Kato, Koji, Kobayashi, Hikaru, Sasahara, Yoji, Sawa, Masashi, Sawada, Akihisa, Hasegawa, Daiichiro, Masuko, Masayoshi, Miyamoto, Toshihiro, and Okamoto, Shinichiro

Published
2020
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20. P789: EFFICACY AND SAFETY OF SWITCHING TO IPTACOPAN (IPTA) MONOTHERAPY IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) TREATED WITH THE ANTI-C5 MONOCLONAL ANTIBODY (MAB) TESIDOLUMAB (TESI)

Author

Ando, Kiyoshi, primary, Griškevičius, Laimonas, additional, Ikezoe, Takayuki, additional, Ito, Yoshikazu, additional, Masuko, Masayoshi, additional, Ueda, Yasutaka, additional, Bagger, Morten, additional, Danekula, Rambabu, additional, Rozenberg, Izabela, additional, Junge, Guido, additional, and Mayer, Jiri, additional

Published
2023
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25. Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan

Author

Ueda, Yasutaka, Obara, Naoshi, Yonemura, Yuji, Noji, Hideyoshi, Masuko, Masayoshi, Seki, Yoshinobu, Wada, Katsuya, Matsuda, Takahisa, Akiyama, Hirozumi, Ikezoe, Takayuki, Chiba, Shigeru, Kanda, Yoshinobu, Kawaguchi, Tatsuya, Shichishima, Tsutomu, Nakakuma, Hideki, Okamoto, Shinichiro, Nishimura, Jun-ichi, Kanakura, Yuzuru, and Ninomiya, Haruhiko

Published
2018
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27. Effect of Granulocyte Colony–Stimulating Factor–Combined Conditioning in Cord Blood Transplantation for Myelodysplastic Syndrome and Secondary Acute Myeloid Leukemia: A Retrospective Study in Japan

Author

Konuma, Takaaki, Takahashi, Satoshi, Uchida, Naoyuki, Kuwatsuka, Yachiyo, Yamasaki, Satoshi, Aoki, Jun, Onishi, Yasushi, Aotsuka, Nobuyuki, Ohashi, Kazuteru, Mori, Takehiko, Masuko, Masayoshi, Nakamae, Hirohisa, Miyamura, Kouichi, Kato, Koji, Atsuta, Yoshiko, Kato, Seiko, Asano, Shigetaka, Takami, Akiyoshi, and Miyazaki, Yasushi

Published
2015
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28. The association of level of reduction of Wilms’ tumor gene 1 mRNA transcript in bone marrow and outcome in acute myeloid leukemia patients

Author

Shibasaki, Yasuhiko, Seki, Yoshinobu, Tanaka, Tomoyuki, Miyakoshi, Syukuko, Fuse, Kyoko, Kozakai, Takashi, Kobayashi, Hironori, Ushiki, Takashi, Abe, Takashi, Yano, Toshio, Moriyama, Masato, Kuroha, Takashi, Isahai, Noriatsu, Takizawa, Jun, Narita, Miwako, Koyama, Satoru, Furukawa, Tatsuo, Sone, Hirohito, and Masuko, Masayoshi

Published
2015
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31. Correction to: Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan

Author

Ueda, Yasutaka, Obara, Naoshi, Yonemura, Yuji, Noji, Hideyoshi, Masuko, Masayoshi, Seki, Yoshinobu, Wada, Katsuya, Matsuda, Takahisa, Akiyama, Hirozumi, Ikezoe, Takayuki, Chiba, Shigeru, Kanda, Yoshinobu, Kawaguchi, Tatsuya, Shichishima, Tsutomu, Nakakuma, Hideki, Okamoto, Shinichiro, Nishimura, Jun-ichi, Kanakura, Yuzuru, and Ninomiya, Haruhiko

Published
2018
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32. Comparison of transplant outcomes between haploidentical transplantation and single cord blood transplantation in non‐remission acute myeloid leukaemia: A nationwide retrospective study

Author

Matsuda, Kensuke, primary, Konuma, Takaaki, additional, Fuse, Kyoko, additional, Masuko, Masayoshi, additional, Kawamura, Koji, additional, Hirayama, Masahiro, additional, Uchida, Naoyuki, additional, Ikegame, Kazuhiro, additional, Wake, Atsushi, additional, Eto, Tetsuya, additional, Doki, Noriko, additional, Miyakoshi, Shigesaburo, additional, Tanaka, Masatsugu, additional, Takahashi, Satoshi, additional, Onizuka, Makoto, additional, Kato, Koji, additional, Kimura, Takafumi, additional, Ichinohe, Tatsuo, additional, Takayama, Nobuyuki, additional, Kobayashi, Hikaru, additional, Nakamae, Hirohisa, additional, Atsuta, Yoshiko, additional, Kanda, Junya, additional, and Yanada, Masamitsu, additional

Published
2022
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33. Incidence and predictors of recurrent sick leave in survivors who returned to work after allogeneic hematopoietic cell transplantation

Author

Kurosawa, Saiko, primary, Yamaguchi, Takuhiro, additional, Mori, Ayako, additional, Matsuura, Tomoko, additional, Masuko, Masayoshi, additional, Murata, Makoto, additional, Tashiro, Haruko, additional, Kako, Shinichi, additional, Satake, Atsushi, additional, Hagihara, Maki, additional, Ota, Shuichi, additional, Saito, Takeshi, additional, Kagawa, Kumiko, additional, Matsuo, Yayoi, additional, Itonaga, Hidehiro, additional, Uoshima, Nobuhiko, additional, Yamaguchi, Hiroki, additional, Naito, Kensuke, additional, Takahashi, Miyako, additional, and Fukuda, Takahiro, additional

Published
2022
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34. YAP1/TAZ activity maintains vascular integrity and organismal survival

Author

Uemura, Shun, primary, Yamashita, Masayuki, additional, Aoyama, Kazumasa, additional, Yokomizo-Nakano, Takako, additional, Oshima, Motohiko, additional, Nishio, Miki, additional, Masuko, Masayoshi, additional, Takizawa, Jun, additional, Sone, Hirohito, additional, Yamada, Yasuhiro, additional, Suzuki, Akira, additional, and Iwama, Atsushi, additional

Published
2022
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35. Prognostic impact of complex karyotype on post‐transplant outcomes of myelofibrosis

Author

Okada, Yosuke, primary, Takenaka, Katsuto, additional, Murata, Makoto, additional, Shimazu, Yutaka, additional, Tachibana, Takayoshi, additional, Ozawa, Yukiyasu, additional, Uchida, Naoyuki, additional, Wakayama, Toshio, additional, Doki, Noriko, additional, Sugio, Yasuhiro, additional, Tanaka, Masatsugu, additional, Masuko, Masayoshi, additional, Kobayashi, Hikaru, additional, Ino, Kazuko, additional, Ishikawa, Jun, additional, Nakamae, Hirohisa, additional, Matsuoka, Ken‐ichi, additional, Kanda, Yoshinobu, additional, Fukuda, Takahiro, additional, Atsuta, Yoshiko, additional, and Nagamura‐Inoue, Tokiko, additional

Published
2022
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36. DA-EPOCH-R therapy for high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements in a patient with renal dysfunction

Author

Mitobe, Masaki, Kawamoto, Keisuke, Suzuki, Takaharu, Suwabe, Tatsuya, Shibasaki, Yasuhiko, Masuko, Masayoshi, Inoue, Kanako, Miyoshi, Hiroaki, Ohshima, Koichi, Sone, Hirohito, and Takizawa, Jun

Subjects
renal impairment, Male, Lymphoma, B-Cell, Biopsy, Case Report, DA-EPOCH-R therapy, urologic and male genital diseases, Kidney Function Tests, Proto-Oncogene Proteins c-myc, immune system diseases, hemic and lymphatic diseases, high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, renal dysfunction, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Cyclophosphamide, In Situ Hybridization, Fluorescence, Etoposide, Neoplasm Staging, Gene Rearrangement, Immunohistochemistry, Treatment Outcome, Proto-Oncogene Proteins c-bcl-2, Doxorubicin, Vincristine, double-hit lymphoma, Proto-Oncogene Proteins c-bcl-6, Prednisone, Female, Kidney Diseases, Neoplasm Grading, Rituximab, Tomography, X-Ray Computed, Biomarkers
Abstract

High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, also known as double-hit lymphoma, has been reported as refractory to R-CHOP therapy and requires more intensive regimens. However, intensive and safe regimens for patients with renal dysfunction are unknown. Herein, we report the successful use of DA-EPOCH-R therapy for double-hit lymphoma in a 64-year-old man with renal dysfunction. The patient had lymphoma-induced bilateral ureteral obstruction. Although renal dysfunction remained after removing the obstruction using R-CHOP therapy, we completed six cycles of DA-EPOCH-R therapy without any major adverse events. DA-EPOCH-R therapy may be a safe regimen for renal dysfunction patients.

Published
2021

37. A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin

Author

Nishida, Tetsuya, Kobayashi, Takeshi, Sawa, Masashi, Masuda, Shinichi, Shibasaki, Yasuhiko, Goto, Tatsunori, Fukuhara, Noriko, Fujii, Nobuharu, Ikegame, Kazuhiro, Sugita, Junichi, Ikeda, Takashi, Kuwatsuka, Yachiyo, Suzuki, Ritsuro, Najima, Yuho, Doki, Noriko, Kato, Tomonori, Inagaki, Yuichiro, Utsu, Yoshikazu, Aotsuka, Nobuyuki, Masuko, Masayoshi, Terakura, Seitaro, Onishi, Yasushi, Maeda, Yoshinobu, Okada, Masaya, Teshima, Takanori, Murata, Makoto, Nishida, Tetsuya, Kobayashi, Takeshi, Sawa, Masashi, Masuda, Shinichi, Shibasaki, Yasuhiko, Goto, Tatsunori, Fukuhara, Noriko, Fujii, Nobuharu, Ikegame, Kazuhiro, Sugita, Junichi, Ikeda, Takashi, Kuwatsuka, Yachiyo, Suzuki, Ritsuro, Najima, Yuho, Doki, Noriko, Kato, Tomonori, Inagaki, Yuichiro, Utsu, Yoshikazu, Aotsuka, Nobuyuki, Masuko, Masayoshi, Terakura, Seitaro, Onishi, Yasushi, Maeda, Yoshinobu, Okada, Masaya, Teshima, Takanori, and Murata, Makoto

Abstract

To overcome the delayed or failed engraftment after unrelated cord blood transplantation (CBT), we conducted a multicenter phase II study of intrabone single-unit CBT without antithymocyte globulin (ATG) for adult patients with hematological malignancies (UMIN-CTR, UMIN000020997). Sixty-four patients received an intrabone injection of unwashed (n = 61) or washed (n = 3) cord blood after local anesthesia. All injection-related adverse events were mild and resolved spontaneously. Sixty-two patients were evaluable for the efficacy of intrabone CBT of serological HLA-A, -B, and -DR ≥ 4/6 matched cord blood with a median number of 2.57 × 10^7/kg cryopreserved total nucleated cells. The probability of survival with neutrophil engraftment on day 28 was 77.4% (95% confidence interval, 67.0–85.8%), which exceeded the threshold value. The cumulative incidences of neutrophils ≥ 0.5 × 10^9/L on day 60 was 80.6% (68.2–88.6%), with a median time to recovery of 21 days after transplantation. The cumulative incidences of platelets ≥ 20 × 10^9/L and platelets ≥ 50 × 10^9/L on day 100 were 75.8% (62.6–84.9%) and 72.6% (59.4–82.1%), respectively, with median time to platelets ≥ 20 × 10^9/L and platelets ≥ 50 × 10^9/L of 38 and 45 days after transplantation, respectively. The cumulative incidences of grade II–IV and III–IV acute graft-versus-host disease were 29.0% and 6.5%, respectively. All responded to steroid therapy, and secondary treatments were not required. The present study suggests the efficacy of intrabone single-unit CBT without ATG in terms of early engraftment and controllable acute graft-versus-host disease.

Published
2022

39. Comparison of transplant outcomes between haploidentical transplantation and single cord blood transplantation in non‐remission acute myeloid leukaemia: A nationwide retrospective study.

Author

Matsuda, Kensuke, Konuma, Takaaki, Fuse, Kyoko, Masuko, Masayoshi, Kawamura, Koji, Hirayama, Masahiro, Uchida, Naoyuki, Ikegame, Kazuhiro, Wake, Atsushi, Eto, Tetsuya, Doki, Noriko, Miyakoshi, Shigesaburo, Tanaka, Masatsugu, Takahashi, Satoshi, Onizuka, Makoto, Kato, Koji, Kimura, Takafumi, Ichinohe, Tatsuo, Takayama, Nobuyuki, and Kobayashi, Hikaru

Subjects
CORD blood transplantation, ACUTE myeloid leukemia, HEMATOPOIETIC stem cell transplantation, TREATMENT effectiveness, PROPENSITY score matching
Abstract

Summary: Allogeneic haematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for some patients with acute myeloid leukaemia (AML) who are refractory to chemotherapy. Cord blood transplantation (CBT) is a reasonable option in such cases because of its rapid availability. Recently, a growing number of human leucocyte antigen (HLA)‐haploidentical related donor HSCTs (haplo‐HSCTs) have been performed, although its effectiveness remains undetermined. Using the Japanese nationwide transplantation registry data, we identified 2438 patients aged ≥16 years who received CBT or haplo‐HSCT as their first transplant for non‐remission AML between January 2008 and December 2018. After 2:1 propensity score matching, 918 patients in the CBT group and 459 patients in the haplo‐HSCT group were selected. In this matched cohort, no significant difference in overall survival (OS) was observed between the CBT and haplo‐HSCT groups (hazard ratio [HR] of haplo‐HSCT to CBT 1.02, 95% confidence interval [CI] 0.89–1.16). Similarly, no significant difference in the cumulative incidence of relapse (HR 1.09, 95% CI 0.93–1.28) or non‐relapse mortality (HR 0.94, 95% CI 0.76–1.18). Subgroup analysis showed that CBT was significantly associated with preferable OS in patients receiving myeloablative conditioning. Our data showed comparable outcomes between haplo‐HSCT and CBT recipients with non‐remission AML. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Registry data analysis of hematopoietic stem cell transplantation on systemic chronic active Epstein–Barr virus infection patients in Japan

Author

Yamamoto, Masahide, primary, Sato, Maho, additional, Onishi, Yasushi, additional, Sasahara, Yoji, additional, Sano, Hideki, additional, Masuko, Masayoshi, additional, Nakamae, Hirohisa, additional, Matsuoka, Ken‐ichi, additional, Ara, Takahide, additional, Washio, Kana, additional, Onizuka, Makoto, additional, Watanabe, Kenichiro, additional, Takahashi, Yoshiyuki, additional, Hirakawa, Tsuneaki, additional, Nishio, Miwako, additional, Sakashita, Chizuko, additional, Kobayashi, Tohru, additional, Sawada, Akihisa, additional, Ichinohe, Tatsuo, additional, Fukuda, Takahiro, additional, Hashii, Yoshiko, additional, Atsuta, Yoshiko, additional, and Arai, Ayako, additional

Published
2022
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41. Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria

Author

Nishimura, Jun-ichi, primary, Ando, Kiyoshi, additional, Masuko, Masayoshi, additional, Noji, Hideyoshi, additional, Ito, Yoshikazu, additional, Mayer, Jiri, additional, Griskevicius, Laimonas, additional, Bucher, Christoph, additional, Müllershausen, Florian, additional, Gergely, Peter, additional, Rozenberg, Izabela, additional, Schubart, Anna, additional, Chawla, Raghav, additional, Rondeau, Jean-Michel, additional, Roguska, Michael, additional, Splawski, Igor, additional, Keating, Mark T., additional, Johnson, Leslie, additional, Danekula, Rambabu, additional, Bagger, Morten, additional, Watanabe, Yoko, additional, Haraldsson, Börje, additional, and Kanakura, Yuzuru, additional

Published
2022
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45. The Outcomes of Systemic Chronic Active EBV Infection Treatment By Allogeneic Hematopoietic Stem Cell Transplantation: An Analysis of Japanese Registry Data

Author

Arai, Ayako, primary, Yamamoto, Masahide, additional, Sato, Maho, additional, Onishi, Yasushi, additional, Sasahara, Yoji, additional, Sano, Hideki, additional, Masuko, Masayoshi, additional, Nakamae, Hirohisa, additional, Matsuoka, Ken-Ichi, additional, Ara, Takahide, additional, Washio, Kana, additional, Onizuka, Makoto, additional, Watanabe, Kenichiro, additional, Hirakawa, Tsuneaki, additional, Nishio, Miwako, additional, Sakashita, Chizuko, additional, Kobayashi, Tohru, additional, Sawada, Akihisa, additional, Ichinohe, Tatsuo, additional, Fukuda, Takahiro, additional, Hashii, Yoshiko, additional, and Atsuta, Yoshiko, additional

Published
2021
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48. Anaplastic large cell lymphoma, with 1,25(OH)2D3-mediated hypercalcemia: A case report

Author

Mitobe, Masaki, Kawamoto, Keisuke, Suzuki, Takaharu, Kiryu, Maiko, Nanba, Ayako, Suwabe, Tatsuya, Tanaka, Tomoyuki, Fuse, Kyoko, Shibasaki, Yasuhiko, Masuko, Masayoshi, Miyoshi, Hiroaki, Ohshima, Koichi, Sone, Hirohito, and Takizawa, Jun

Subjects
Aged, 80 and over, Male, anaplastic large cell lymphoma, Fluorodeoxyglucose F18, hemic and lymphatic diseases, Positron Emission Tomography Computed Tomography, Hypercalcemia, Humans, Lymphoma, Large-Cell, Anaplastic, Case Report, Vitamin D, 1,25-dihydroxyvitamin D3
Abstract

Hypercalcemia due to malignant tumors including malignant lymphomas is relatively common. Among cancer patients with hypercalcemia, humoral hypercalcemia of malignancy is the most common and accounts for about 80% of all cases with hypercalcemia. 1,25-dihydroxyvitamin D3(1,25(OH)2D3)-mediated hypercalcemia is relatively rare. Although malignant lymphoma has been also reported to cause 1,25(OH)2D3-mediated hypercalcemia, it is not known whether there is any association between 1,25(OH)2D3-mediated hypercalcemia and any specific histological type of malignant lymphoma. We herein report a case of an anaplastic large cell lymphoma (ALCL), anaplastic lymphoma kinase (ALK) -negative with 1,25(OH)2D3-mediated hypercalcemia, which has never been previously reported. An 80-year-old Japanese man was admitted to our department due to acute exacerbation of hypercalcemia. He was diagnosed with ALCL, ALK-negative. Serum 1,25(OH)2D3 level was high and seemed to be associated with the lymphoma because the serum calcium and 1,25(OH)2D3 levels improved in response to chemotherapy. Histological findings showed that many CD68 positive macrophages were observed in the microenvironment of tumor cells. Lymphoma cells or tumor microenvironmental cells may produce 1,25(OH)2D3 because several previous reports showed the source of 1,25(OH)2D3 can be either lymphoma or tumor microenvironmental cells. Moreover, because 1,25(OH)2D3-mediated hypercalcemia has been reported regardless of the specific histological type of lymphoma, tumor microenvironmental cells may be involved in this condition. However, we could not identify the source of 1,25(OH)2D3 in this case. The association between 1,25(OH)2D3 production and prognosis in malignant lymphomas is yet unknown; further studies are needed to elucidate the clinical characteristics of malignant lymphoma with 1,25(OH)2D3-mediated hypercalcemia.

Published
2019

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