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4. A reference equation for lung volume on computed tomography in Japanese middle-aged and elderly adults

Author

Tanabe, Naoya, Sato, Susumu, Shimada, Takafumi, Kaji, Shizuo, Shiraishi, Yusuke, Terada, Satoru, Maetani, Tomoki, Mochizuki, Fumi, Shimizu, Kaoruko, Suzuki, Masaru, Chubachi, Shotaro, Terada, Kunihiko, Tanimura, Kazuya, Sakamoto, Ryo, Oguma, Tsuyoshi, Sato, Atsuyasu, Kanasaki, Megumi, Muro, Shigeo, Masuda, Izuru, Iijima, Hiroaki, and Hirai, Toyohiro

Published
2024
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11. Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study

Author

Yamakage, Hajime, primary, Jo, Takaaki, additional, Tanaka, Masashi, additional, Kato, Sayaka, additional, Hasegawa, Koji, additional, Masuda, Izuru, additional, Matsuhisa, Munehide, additional, Kotani, Kazuhiko, additional, Noda, Mitsuhiko, additional, and Satoh-Asahara, Noriko, additional

Published
2024
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15. Centrilobular emphysema and airway dysanapsis: Factors associated with low respiratory function in younger smokers

Author

Mochizuki, Fumi, primary, Tanabe, Naoya, additional, Shimada, Takafumi, additional, Iijima, Hiroaki, additional, Sakamoto, Ryo, additional, Shiraishi, Yusuke, additional, Maetani, Tomoki, additional, Shimizu, Kaoruko, additional, Suzuki, Masaru, additional, Chubachi, Shotaro, additional, Ishikawa, Hiroichi, additional, Naito, Takashi, additional, Kanasaki, Megumi, additional, Masuda, Izuru, additional, Oguma, Tsuyoshi, additional, Sato, Susumu, additional, Hizawa, Nobuyuki, additional, and Hirai, Toyohiro, additional

Published
2024
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21. Centrilobular Emphysema Is Associated with Pectoralis Muscle Reduction in Current Smokers without Airflow Limitation

Author

Maetani, Tomoki, primary, Tanabe, Naoya, additional, Shiraishi, Yusuke, additional, Shimada, Takafumi, additional, Terada, Satoru, additional, Shima, Hiroshi, additional, Mochizuki, Fumi, additional, Sakamoto, Ryo, additional, Kaji, Shizuo, additional, Oguma, Tsuyoshi, additional, Sato, Susumu, additional, Iijima, Hiroaki, additional, Masuda, Izuru, additional, and Hirai, Toyohiro, additional

Published
2023
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24. PS-P15-8: EFFICACY AND SAFETY OF ESAXERENONE IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES AND RECEIVING SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITORS (EAGLE-DH STUDY)

Author

Motoki, Hirohiko, primary, Inobe, Yoshito, additional, Fukui, Toshiki, additional, Iwasaki, Arata, additional, Hiramitsu, Shinya, additional, Koyama, Sekiya, additional, Masuda, Izuru, additional, Sekimura, Noriyuki, additional, Yamamoto, Kazuya, additional, Sato, Ai, additional, Komatsu, Mitsuhisa, additional, Taguchi, Takashi, additional, Shiosakai, Kazuhito, additional, Sugimoto, Kotaro, additional, and Kuwahara, Koichiro, additional

Published
2023
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27. The prevalence and physiological impacts of centrilobular and paraseptal emphysema on computed tomography in smokers with preserved ratio impaired spirometry

Author

30805817, 50741930, Shiraishi, Yusuke, Shimada, Takafumi, Tanabe, Naoya, Terada, Kunihiko, Sakamoto, Ryo, Maetani, Tomoki, Shima, Hiroshi, Mochizuki, Fumi, Oguma, Tsuyoshi, Shimizu, Kaoruko, Sato, Susumu, Muro, Shigeo, Hizawa, Nobuyuki, Fukui, Motonari, Iijima, Hiroaki, Masuda, Izuru, Hirai, Toyohiro, 30805817, 50741930, Shiraishi, Yusuke, Shimada, Takafumi, Tanabe, Naoya, Terada, Kunihiko, Sakamoto, Ryo, Maetani, Tomoki, Shima, Hiroshi, Mochizuki, Fumi, Oguma, Tsuyoshi, Shimizu, Kaoruko, Sato, Susumu, Muro, Shigeo, Hizawa, Nobuyuki, Fukui, Motonari, Iijima, Hiroaki, Masuda, Izuru, and Hirai, Toyohiro

Abstract

Centrilobular emphysema (CLE) and paraseptal emphysema (PSE) are observed in smokers with preserved ratio impaired spirometry (PRISm, defined as the ratio of forced expiratory volume in 1 s (FEV₁) to forced vital capacity (FVC) ≥0.7 and FEV₁ <80%), but their prevalence and physiological impacts remain unestablished. This multicentre study aimed to investigate its prevalence and to test whether emphysema subtypes are differently associated with physiological impairments in smokers with PRISm. Both never- and ever-smokers aged ≥40 years who underwent computed tomography (CT) for lung cancer screening and spirometry were retrospectively and consecutively enrolled at three hospitals and a clinic. Emphysema subtypes were visually classified according to the Fleischner system. Air-trapping was assessed as the ratio of FVC to total lung capacity on CT (TLCᴄᴛ). In 1046 never-smokers and 772 smokers with ≥10 pack-years, the prevalence of PRISm was 8.2% and 11.3%, respectively. The prevalence of PSE and CLE in smokers with PRISm was comparable to that in smokers with normal spirometry (PSE 43.7% versus 36.2%, p=1.00; CLE 46.0% versus 31.8%, p=0.21), but higher than that in never-smokers with PRISm (PSE 43.7% versus 1.2%, p<0.01; CLE 46% versus 4.7%, p<0.01) and lower than that in smokers with airflow limitation (PSE 43.7% versus 71.0%, p<0.01; CLE 46% versus 79.3%, p<0.01). The presence of CLE, but not PSE, was independently associated with reduced FVC/TLCᴄᴛ in smokers with PRISm.Both PSE and CLE were common, but only CLE was associated with air-trapping in smokers with PRISm, suggesting different physiological roles of these emphysema subtypes.

Published
2022

28. Clinical relevance of multiple confirmed preserved ratio impaired spirometry cases in adults

Author

30805817, 30706677, Tanabe, Naoya, Masuda, Izuru, Shiraishi, Yusuke, Maetani, Tomoki, Hamada, Satoshi, Sato, Atsuyasu, Sato, Susumu, Hirai, Toyohiro, 30805817, 30706677, Tanabe, Naoya, Masuda, Izuru, Shiraishi, Yusuke, Maetani, Tomoki, Hamada, Satoshi, Sato, Atsuyasu, Sato, Susumu, and Hirai, Toyohiro

Abstract

BACKGROUND: Preserved ratio impaired spirometry (PRISm) is a common spirometry finding, but its heterogeneous manifestations and frequent transitions to airflow limitation (AFL), chronic obstructive pulmonary disease, or normal spirometry hinder establishing an appropriate management strategy. This study examined whether transition to AFL and baseline comorbidities are more frequent in subjects with definite PRISm (PRISm confirmed on both current and past two spirometry tests) versus incident PRISm (PRISm confirmed only on a current test with past normal spirometry records) than in normal spirometry. METHODS: Archived medical check-up data of subjects aged ≥40 years (n = 10828) with two past spirometry records, in a Japanese hospital, were cross-sectionally analyzed. Among them, data from those with follow-up spirometry after three years (n = 6467) were used to evaluate transition to AFL. PRISm was defined as forced volume in 1 s (FEV1)/forced vital capacity ≥0.7 and % predicted FEV1 < 80%. RESULTS: Overall PRISm prevalence was 6.5%. In multivariable models adjusted for age, sex, smoking status, and body mass index, definite PRISm (n = 290), but not incident PRISm (n = 183), was associated with elevated hemoglobin A1c and C-reactive protein levels, and higher rates of asthma, hypertension, hyperlipidemia, and diabetes than was consistent normal spirometry (n = 9694). The transition to AFL after three years was more frequent in definite PRISm, but not incident PRISm, than in normal spirometry (adjusted hazard ratio [95% confidence interval] = 6.21 [3.42-10.71] and 1.45 [0.23-4.73], respectively). CONCLUSIONS: Multiple confirmed PRISm on past and baseline spirometry is closely associated with metabolic syndrome factors, asthma history, and future AFL development.

Published
2022

31. The prevalence and physiological impacts of centrilobular and paraseptal emphysema on computed tomography in smokers with preserved ratio impaired spirometry

Author

Shiraishi, Yusuke, primary, Shimada, Takafumi, additional, Tanabe, Naoya, additional, Terada, Kunihiko, additional, Sakamoto, Ryo, additional, Maetani, Tomoki, additional, Shima, Hiroshi, additional, Mochizuki, Fumi, additional, Oguma, Tsuyoshi, additional, Shimizu, Kaoruko, additional, Sato, Susumu, additional, Muro, Shigeo, additional, Hizawa, Nobuyuki, additional, Fukui, Motonari, additional, Iijima, Hiroaki, additional, Masuda, Izuru, additional, and Hirai, Toyohiro, additional

Published
2022
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33. Abstract 13849: Association of Optimal Blood Pressure and Risk of Atrial Fibrillation in Aged Type 2 Diabetes Mellitus Patients: From the JPAD Cohort Study

Author

Matsumoto, Chisa, primary, Ogawa, Hisao, additional, Saito, Yoshihiko, additional, Okada, Sadanori, additional, Soejima, Hirofumi, additional, Sakuma, Mio, additional, Masuda, Izuru, additional, Nakayama, Masafumi, additional, Doi, Naofumi, additional, Jinnouchi, Hideaki, additional, Waki, Masako, additional, and Morimoto, Takeshi, additional

Published
2021
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36. INCIDENCE OF NONVALVULAR ATRIAL FIBRILLATION IN AGED TYPE 2 DIABETES MELLITUS PATIENTS: FROM JPAD COHORT STUDY

Author

Matsumoto, Chisa, primary, Ogawa, Hisao, additional, Saito, Yoshihiko, additional, Okada, Sadanori, additional, Soejima, Hirofumi, additional, Sakuma, Mio, additional, Masuda, Izuru, additional, Nakayama, Masafumi, additional, Doi, Naofumi, additional, Jinnouchi, Hideaki, additional, Waki, Masako, additional, and Morimoto, Takeshi, additional

Published
2021
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37. Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy

Author

Hatae, Ryusuke, Chamoto, Kenji, Kim, Young Hak, Sonomura, Kazuhiro, Taneishi, Kei, Kawaguchi, Shuji, Yoshida, Hironori, Ozasa, Hiroaki, Sakamori, Yuichi, Akrami, Maryam, Fagarasan, Sidonia, Masuda, Izuru, Okuno, Yasushi, Matsuda, Fumihiko, Hirai, Toyohiro, and Honjo, Tasuku

Abstract

BACKGROUND. Current clinical biomarkers for the programmed cell death 1 (PD-1) blockade therapy are insufficient because they rely only on the tumor properties, such as programmed cell death ligand 1 expression frequency and tumor mutation burden. Identifying reliable, responsive biomarkers based on the host immunity is necessary to improve the predictive values. METHODS. We investigated levels of plasma metabolites and T cell properties, including energy metabolism markers, in the blood of patients with non-small cell lung cancer before and after treatment with nivolumab (n = 55). Predictive values of combination markers statistically selected were evaluated by cross-validation and linear discriminant analysis on discovery and validation cohorts, respectively. Correlation between plasma metabolites and T cell markers was investigated. RESULTS. The 4 metabolites derived from the microbiome (hippuric acid), fatty acid oxidation (butyrylcarnitine), and redox (cystine and glutathione disulfide) provided high response probability (AUC = 0.91). Similarly, a combination of 4 T cell markers, those related to mitochondrial activation (PPARγ coactivator 1 expression and ROS), and the frequencies of CD8+PD-1hi and CD4+ T cells demonstrated even higher prediction value (AUC = 0.96). Among the pool of selected markers, the 4 T cell markers were exclusively selected as the highest predictive combination, probably because of their linkage to the abovementioned metabolite markers. In a prospective validation set (n = 24), these 4 cellular markers showed a high accuracy rate for clinical responses of patients (AUC = 0.92). CONCLUSION. Combination of biomarkers reflecting host immune activity is quite valuable for responder prediction., PD-1抗体がん免疫治療の有効性を判別するバイオマーカーを同定 --血液検査のみで有効性の診断が可能に--. 京都大学プレスリリース. 2020-01-31.

Published
2020

38. Association Between Statins and Cancer Incidence in Diabetes: a Cohort Study of Japanese Patients with Type 2 Diabetes

Author

Okada, Sadanori, primary, Morimoto, Takeshi, additional, Ogawa, Hisao, additional, Soejima, Hirofumi, additional, Matsumoto, Chisa, additional, Sakuma, Mio, additional, Nakayama, Masafumi, additional, Doi, Naofumi, additional, Jinnouchi, Hideaki, additional, Waki, Masako, additional, Masuda, Izuru, additional, and Saito, Yoshihiko, additional

Published
2020
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39. Rationale and design of the EMPYREAN study

Author

Motoki, Hirohiko, primary, Masuda, Izuru, additional, Yasuno, Shinji, additional, Oba, Koji, additional, Shoin, Wataru, additional, Usami, Satoru, additional, Saito, Yoshihiko, additional, Waki, Masako, additional, Komatsu, Mitsuhisa, additional, Ueshima, Kenji, additional, Nakagawa, Yasuaki, additional, Son, Cheol, additional, Yonemitsu, Shin, additional, Hiramitsu, Shinya, additional, Konda, Manako, additional, Onishi, Katsuya, additional, and Kuwahara, Koichiro, additional

Published
2020
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41. Rationale and Design of the EMPYREAN Study: Investigation on the Effect of Empagliflozin on Cardiac Sympathetic and Parasympathetic Nerve Activity in Japanese Patients with Type 2 Diabetes

Author

Motoki, Hirohiko, primary, Masuda, Izuru, additional, Yasuno, Shinji, additional, Oba, Koji, additional, Shoin, Wataru, additional, Usami, Satoru, additional, Saito, Yoshihiko, additional, Waki, Masako, additional, Komatsu, Mitsuhisa, additional, Ueshima, Kenji, additional, Nakagawa, Yasuaki, additional, Son, Cheol, additional, Yonemitsu, Shin, additional, Hiramitsu, Shinya, additional, Konda, Manako, additional, Onishi, Katsuya, additional, and Kuwahara, Koichiro, additional

Published
2020
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43. Rationale and Design of the CANONICAL Study ― Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Canagliflozin for Heart Failure With Preserved Ejection Fraction With Type 2 Diabetes Mellitus ―

Author

Kasama, Shu, primary, Masuyama, Tohru, additional, Uemura, Shiro, additional, Sato, Yukihito, additional, Hiramitsu, Shinya, additional, Masuda, Izuru, additional, Yamamoto, Kazuhiro, additional, Komatsu, Sei, additional, Anzai, Toshihisa, additional, Nishimura, Kunihiro, additional, Ueda, Tomoya, additional, Kasahara, Masato, additional, Tanaka, Hiroyuki, additional, Susuta, Yutaka, additional, and Saito, Yoshihiko, additional

Published
2019
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44. Association of locomotive activity with sleep latency and cognitive function of elderly patients with cardiovascular disease in the maintenance phase of cardiac rehabilitation

Author

Kurose, Satoshi, primary, Miyauchi, Takumi, additional, Yamashita, Ryo, additional, Tamaki, Shohei, additional, Imai, Masaru, additional, Nakashima, Yuri, additional, Umeda, Yoko, additional, Sato, Shinji, additional, Kimura, Yutaka, additional, and Masuda, Izuru, additional

Published
2019
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46. One quarter of total myocardial infarctions are silent manifestation in patients with type 2 diabetes mellitus

Author

Soejima, Hirofumi, primary, Ogawa, Hisao, additional, Morimoto, Takeshi, additional, Okada, Sadanori, additional, Sakuma, Mio, additional, Nakayama, Masafumi, additional, Masuda, Izuru, additional, Doi, Naofumi, additional, Uemura, Shiro, additional, Jinnouchi, Hideaki, additional, Sugiyama, Seigo, additional, Waki, Masako, additional, and Saito, Yoshihiko, additional

Published
2019
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48. Sex Difference in Effects of Low-Dose Aspirin on Prevention of Dementia in Patients With Type 2 Diabetes: A Long-term Follow-up Study of a Randomized Clinical Trial.

Author

Chisa Matsumoto, Hisao Ogawa, Yoshihiko Saito, Sadanori Okada, Hirofumi Soejima, Mio Sakuma, Izuru Masuda, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi, Masako Waki, Takeshi Morimoto, Matsumoto, Chisa, Ogawa, Hisao, Saito, Yoshihiko, Okada, Sadanori, Soejima, Hirofumi, Sakuma, Mio, Masuda, Izuru, and Nakayama, Masafumi

Subjects
TYPE 2 diabetes, DEMENTIA patients, CLINICAL trials, ASPIRIN, DRUGS, TYPE 2 diabetes & psychology, DEMENTIA prevention, ATHEROSCLEROSIS prevention, HUMAN reproduction, RESEARCH, RESEARCH methodology, DISEASE incidence, EVALUATION research, MEDICAL cooperation, PREVENTIVE health services, ATHEROSCLEROSIS, COMPARATIVE studies, RANDOMIZED controlled trials, DOSE-effect relationship in pharmacology, DEMENTIA, LONGITUDINAL method, PHARMACODYNAMICS, DISEASE complications
Abstract

Objective: To evaluate and compare the efficacy of long-term use of low-dose aspirin for the prevention of dementia in men and women.Research Design and Methods: This study is a follow-up cohort study of the Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) trial, which was a randomized, open-label, standard care-controlled trial examining the effects of low-dose aspirin on cardiovascular events. We followed up 2,536 Japanese patients with type 2 diabetes (T2D) enrolled in the JPAD trial from 2002 to 2017. The primary outcome of this post hoc analysis was the incidence of dementia, which was defined by the prescription of antidementia drugs or admission due to dementia.Results: Among the originally enrolled patients, 2,121 (84%) retained their original allocation. During a median follow-up of 11.4 years, 128 patients developed dementia. The overall effect of low-dose aspirin on the prevention of dementia adjusted for age, sex, and other established risk factors was not significant (hazard ratio [HR] 0.82, 95% CI 0.58-1.16). However, a significant reduction was seen in the risk of dementia in women (HR 0.58, 95% CI 0.36-0.95), but not in men (HR 1.27, 95% CI 0.75-2.13) (Pinteraction = 0.03).Conclusions: Long-term use of low-dose aspirin may reduce the risk for dementia in women with T2D. [ABSTRACT FROM AUTHOR]

Published
2020
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