Author: "Mastrogiovanni, M" - Searchworks@Jio Institute Digital Library Search Results

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73 results on '"Mastrogiovanni, M"'

1. A methodology for accelerated design of irradiation experiments: Demonstration via an OpenFOAM-informed TRANSURANUS simulation

Author: Di Gennaro, M., Magni, A., Mastrogiovanni, M., Luzzi, L., and Pizzocri, D.
Published: 2024
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2. Novel antiplatelet role for a protein disulfide isomerase‐targeted peptide: evidence of covalent binding to the C‐terminal CGHC redox motif

Author: Sousa, H.R., Gaspar, R.S., Sena, E.M.L., da Silva, S.A., Fontelles, J.L., AraUjo, T.L.S., Mastrogiovanni, M., Fries, D.M., Azevedo‐Santos, A.P.S., Laurindo, F.R.M., Trostchansky, A., and Paes, A.M.
Published: 2017
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3. The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration. Insights from familial polyposis patients

Author: Mastrogiovanni M, Di Bartolo, Céline Cuche, Delon J, Thierry Rose, Juzans M, Andrés Alcover, Charlotte Renaudat, Esposito E, Marie-Noëlle Ungeheuer, Vargas P, and Laude H
Subjects: biology, Cytoskeleton organization, Chemistry, Adenomatous polyposis coli, T cell, Integrin, Wnt signaling pathway, medicine.disease, Cell biology, Familial adenomatous polyposis, medicine.anatomical_structure, Cell polarity, biology.protein, T cell migration, medicine
Abstract: Adenomatous polyposis coli (APC) is a tumor suppressor whose mutations underlie familial adenomatous polyposis (FAP) and colorectal cancer. Although its role in intestinal epithelial cells is well characterized, APC importance for anti-tumor immunity is ill defined. Besides its role in Wnt/β-catenin signaling, APC regulates cytoskeleton organization, cell polarity and migration in various cells types. Here we address whether APC plays a role in T lymphocyte migration, a key step of anti-tumor immune responses. Using a series of cell biology tools, we measured migration of primary T cells obtained from FAP patients carrying APC mutations. FAP T cells showed decreased chemotaxis through micropores or endothelial cell monolayers. Concomitantly, they presented lower expression of the VLA-4 (α4β1) integrin at the cell surface. Notably, adhesion and migration in micro-fabricated channels were specifically reduced when surfaces were coated with VLA-4 ligands, indicating that defective adhesion could lead to decreased T cell migration. To further dissect the cellular mechanisms underpinning APC-mediated defects, we depleted APC in the CEM T cell line. We found that APC is critical for VLA-4-dependent adhesion, and acto-myosin and microtubule organization in migrating cells. APC-silenced CEM cells preferentially adopt an ameboid-like migration, lacking adhesive filopodia and continuously extending and retracting unstructured membrane protrusions. These findings underscore a role of APC in T cell migration via modulation of integrin-dependent adhesion and cytoskeleton reorganization. Hence, APC mutations in FAP patients not only unbalance epithelial homeostasis, driving intestinal neoplasms, but also impair T cell migration, potentially leading to inefficient T cell-mediated anti-tumor immunity.
Published: 2021
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4. ReIA/NF-kB and STAT3 transcription factors cooperate in trans-activating the human IL-17A proximal promoter in response to CD28 individual stimulation

Author: Kunkl, M, Mastrogiovanni, M, Porciello, N, Caristi, S, Monteleone, E, Arcieri, S, and Tuosto, L
Subjects: STAT3, CD28, T lymphocytes, IL-17A, NF-kappa B
Published: 2019

5. Low-latency Gravitational-wave Alerts for Multimessenger Astronomy during the Second Advanced LIGO and Virgo Observing Run

Author: Abbott, (Abbott, Bp, Abbott, B. P., (Abbott, R, Abbott, R., (Abbott, Td, Abraham, T. D., (Abraham, S, Acernese, S., (Acernese, F, Ackley, F., (Ackley, K, Adams, K., (Adams, C, Adhikari, C., (Adhikari, Rx, Adya, R. X., (Adya, Vb, Affeldt, V. B., (Affeldt, C, Agathos, C., (Agathos, M, Agatsuma, M., (Agatsuma, K, Aggarwal, K., (Aggarwal, N, Aguiar, N., (Aguiar, Od, Aiello, O. D., (Aiello, L, Ain, L., (Ain, A, Ajith, A., (Ajith, P, Allen, P., (Allen, G, Allocca, G., (Allocca, A, Aloy, A., (Aloy, Ma, Altin, M. A., (Altin, Pa, Amato, P. A., (Amato, A, Ananyeva, A., (Ananyeva, A, Anderson, A., (Anderson, Sb, Anderson, S. B., (Anderson, Wg, Angelova, W. G., (Angelova, Sv, V), S., Antier, (Antier, S, Appert, S., (Appert, S, Arai, S., (Arai, K, Araya, K., (Araya, Mc, Areeda, M. C., (Areeda, Js, Arene, J. S., (Arene, M, Arnaud, M., (Arnaud, N, Ascenzi, N., (Ascenzi, S, Ashton, S., (Ashton, G, Aston, G., (Aston, Sm, Astone, S. 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P., Rowan43, S., Rüdiger8, A., 180, 9, Ruggi28, P., Rutins166, G., Ryan44, K., Sachdev1, S., Sadecki44, T., Sakellariadou131, M., Salconi28, L., Saleem141, M., Samajdar36, A., Sammut6, L., Sanchez1, E. J., Sanchez1, L. E., Sanchis-Gual20, N., Sandberg44, V., Sanders41, J. R., Santiago34, K. A., Sarin6, N., Sassolas22, B., Saulson41, P. R., Sauter125, O., Savage44, R. L., Schale69, P., Scheel45, M., Scheuer58, J., Schmidt63, P., Schnabel139, R., Schofield69, R. M. S., Schönbeck139, A., Schreiber8, E., Schulte8, B. W., Schutz67, B. F., Schwalbe33, S. G., Scott43, J., Scott21, S. M., Seidel17, E., Sellers7, D., Sengupta167, A. S., Sennett35, N., Sentenac28, D., Sequino14, V., Sergeev134, A., Setyawati8, Y., Shaddock21, D. A., Shaffer44, T., Shahriar58, M. S., Shaner110, M. B., Shao35, L., Sharma60, P., Shawhan75, P., Shen17, H., Shink168, R., Shoemaker12, D. H., Shoemaker76, D. M., Shyamsundar60, S., Siellez76, K., Sieniawska53, M., Sigg44, D., Silva13, A. D., Singer79, L. P., Singh73, N., Singhal14, A., Sintes98, A. M., Sitmukhambetov103, S., Skliris67, V., Slagmolen21, B. J. J., Slaven-Blair62, T. J., Smith26, J. R., Smith6, R. J. E., Somala169, S., Son137, E. J., Sorazu43, B., Sorrentino59, F., Souradeep3, T., Sowell83, E., Spencer43, A. P., Srivastava106, A. K., Srivastava41, V., Staats58, K., Stachie64, C., Standke8, M., Steer27, D. A., Steinke8, M., Steinlechner43, J., Steinlechner139, S., Steinmeyer8, D., Stevenson152, S. P., Stocks48, D., Stone103, R., Stops11, D. J., Strain43, K. A., Stratta71, G., Strigin61, S. E., Strunk44, A., Sturani170, R., Stuver171, A. L., Sudhir12, V., Summerscales172, T. Z., Sun1, L., Sunil106, S., Suresh3, J., Sutton67, P. J., Swinkels36, B. L., Szczepańczyk33, M. J., Tacca36, M., Tait43, S. C., Talbot6, C., Talukder69, D., Tanner47, D. B., Tápai122, M., Taracchini35, A., Tasson93, J. D., Taylor1, R., Thies8, F., Thomas7, M., Thomas44, P., Thondapu60, S. R., Thorne7, K. A., Thrane6, E., Tiwari95, Shubhanshu, Tiwari123, Srishti, Tiwari67, V., Toland43, K., Tonelli18, M., Tornasi43, Z., Torres-Forné173, A., Torrie1, C. I., Töyrä11, D., Travasso28, F., Traylor7, G., Tringali73, M. C., Trovato27, A., Trozzo19, L., Trudeau1, R., Tsang36, K. W., Tse12, M., Tso45, R., Tsukada81, L., Tsuna81, D., Tuyenbayev103, D., Ueno81, K., Ugolini175, D., Unnikrishnan123, C. S., Urban2, A. L., Usman67, S. A., Vahlbruch9, H., Vajente1, G., Valdes2, G., van Bakel36, N., van Beuzekom36, M., van den Brand36, J. F. J., Van Den Broeck36, C., Vander-Hyde41, D. C., van Heijningen62, J. V., van der Schaaf36, L., van Veggel43, A. A., Vardaro50, M., Varma45, V., Vass1, S., Vasúth46, M., Vecchio11, A., Vedovato51, G., Veitch43, J., Veitch54, P. J., Venkateswara165, K., Venugopalan1, G., Verkindt32, D., Vetrano71, F., Viceré71, A., Viets23, A. D., Vine166, D. J., Vinet64, J. -Y., Vitale12, S., Vo41, T., Vocca39, H., Vorvick44, C., Vyatchanin61, S. P., Wade1, A. R., Wade114, L. E., Wade114, M., Walet36, R., Walker26, M., Wallace1, L., Walsh23, S., Wang14, G., Wang11, H., Wang125, J. Z., Wang103, W. H., Wang90, Y. F., Ward21, R. L., Warden33, Z. A., Warner44, J., Was32, M., Watchi99, J., Weaver44, B., Wei8, L. -W., Weinert8, M., Weinstein1, A. J., Weiss12, R., Wellmann8, F., Wen62, L., Wessel17, E. K., Weßels8, P., Westhouse33, J. W., Wette21, K., Whelan57, J. T., Whiting47, B. F., Whittle12, C., Wilken8, D. M., Williams43, D., Williamson36, A. R., Willis1, J. L., Willke8, B., Wimmer8, M. H., Winkler8, W., Wipf1, C. C., Wittel8, H., Woan43, G., Woehler8, J., Wofford57, J. K., Worden44, J., Wright43, J. L., Wu8, D. S., Wysocki57, D. M., Xiao1, L., Yamamoto1, H., Yancey75, C. C., Yang113, L., Yap21, M. J., Yazback47, M., Yeeles67, D. W., Yu12, Hang, Yu12, Haocun, Yuen90, S. H. R., Yvert32, M., Zadrożny103, A. 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Srivastava, A, Steer, D, Stevenson, S, Stops, D, Strain, K, Strigin, S, Stuver, A, Summerscales, T, Sutton, P, Swinkels, B, Szczepanczyk, M, Tait, S, Tanner, D, Tasson, J, Thondapu, S, Thorne, K, Torrie, C, Tringali, M, Tsang, K, Urban, A, Usman, S, Van Bakel, N, Van Beuzekom, M, Van Den Brand, J, Broeck, C, Vander-Hyde, D, Van Heijningen, J, Van Der Schaaf, L, Van Veggel, A, Veitch, P, Viets, A, Vine, D, Vinet, J, Vyatchanin, S, Wade, A, Wade, L, Wang, J, Wang, W, Wang, Y, Ward, R, Warden, Z, Wei, L, Weinstein, A, Wessel, E, Westhouse, J, Whelan, J, Whiting, B, Wilken, D, Williamson, A, Willis, J, Wimmer, M, Wipf, C, Wofford, J, Wright, J, Wysocki, D, Yancey, C, Yap, M, Yeeles, D, Yuen, S, Zadrozny, A, Zendri, J, Zimmerman, A, Zhu, X, Zucker, M, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), (Astro)-Particles Physics, The LIGO Scientific Collaboration, The Virgo Collaboration, IoP (FNWI), and Astroparticle Physics (IHEF, IoP, FNWI)
Subjects: 010504 meteorology & atmospheric sciences, data acquisition, Astronomy, 01 natural sciences, black hole, optical, LIGO, gravitational waves, methods: data analysis, gravitational wave, 010303 astronomy & astrophysics, QC, QB, High Energy Astrophysical Phenomena (astro-ph.HE), Settore FIS/01, astro-ph.HE, Physics, NUCLEOSYNTHESIS, radio wave, COMPACT BINARIES, EJECTION, gravitational waves, neutron stars, Physical Sciences, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, on-line, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, NEUTRON-STAR MERGERS, gamma ray: burst, Astronomy & Astrophysics, X-ray, General Relativity and Quantum Cosmology, SDG 17 - Partnerships for the Goals, RAY BURSTS, 0103 physical sciences, data analysis [methods], STFC, 0105 earth and related environmental sciences, Science & Technology, Gravitational wave, gravitational radiation, Online identification, RCUK, Astronomy and Astrophysics, messenger, Neutron star, VIRGO, electromagnetic, Physics and Astronomy, Space and Planetary Science, RADIATION, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Gamma-ray burst, neutron star: coalescence
Abstract: Advanced LIGO's second observing run (O2), conducted from November 30, 2016 to August 25, 2017, combined with Advanced Virgo's first observations in August 2017 witnessed the birth of gravitational-wave multi-messenger astronomy. The first ever gravitational-wave detection from the coalescence of two neutron stars, GW170817, and its gamma-ray counterpart, GRB 170817A, led to an electromagnetic follow-up of the event at an unprecedented scale. Several teams from across the world searched for EM/neutrino counterparts to GW170817, paving the way for the discovery of optical, X-ray, and radio counterparts. In this article, we describe the online identification of gravitational-wave transients and the distribution of gravitational-wave alerts by the LIGO and Virgo collaborations during O2. We also describe the gravitational-wave observables which were sent in the alerts to enable searches for their counterparts. Finally, we give an overview of the online candidate alerts shared with observing partners during O2. Alerts were issued for 14 candidates, six of which have been confirmed as gravitational-wave events associated with the merger of black holes or neutron stars. Eight of the 14 alerts were issued less than an hour after data acquisition., Comment: 27 pages, 5 figures, 3 tables, accepted for publication in the Astrophysical Journal
Published: 2019
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6. Search for gravitational waves from Scorpius X-1 in the first Advanced LIGO observing run with a hidden Markov model

Author: Abbott, and Abbott, B. P., and Abbott, R., and Acernese, D., and Ackley, F., and Adams, K., and Adams, C., and Addesso, T., and Adhikari, P., and Adya, R. X., and Affeldt, V. B., and Afrough, C., and Agarwal, M., and Agatsuma, B., and Aggarwal, K., and Aguiar, N., and Aiello, O. D., and Ain, L., and Ajith, A., and Allen, P., and Allen, B., and Allocca, G., and Almoubayyed, A., and Altin, H., and Amato, P. A., and Ananyeva, A., and Anderson, A., and Anderson, S. B., and Antier, W. G., and Appert, S., and Arai, S., and Araya, K., and Areeda, M. C., and Arnaud, J. S., and Arun, N., and Ascenzi, K. G., and Ashton, S., and Ast, G., and Aston, M., and Astone, S. M., and Aufmuth, P., and Aulbert, P., and AultONeal, C., and Avila-Alvarez, K., and Babak, A., and Bacon, S., and Bader, P., and Bae, M. K. M., and Baker, S., and Baldaccini, P. T., and Ballardin, F., and Ballmer, G., and Banagiri, S. W., and Barayoga, S., and Barclay, J. C., and Barish, S. E., and Barker, B. 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J., Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire de la Côte d'Azur (OCA), Centre National de la Recherche Scientifique (CNRS), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Kastler Brossel (LKB [Collège de France]), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Collège de France (CdF)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ESPCI ParisTech, LIGO Scientific, VIRGO, Abbott, B. .p., Abbott, R., Abbott, T. .d., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R. .x., Adya, V. .b., Affeldt, C., Afrough, M., Agarwal, B., Agatsuma, K., Aggarwal, N., Aguiar, O. .d., Aiello, L., Ain, A., Ajith, P., Allen, B., Allen, G., Allocca, A., Almoubayyed, H., Altin, P. .a., Amato, A., Ananyeva, A., Anderson, S. .b., Anderson, W. .g., Antier, S., Appert, S., Arai, K., Araya, M. .c., Areeda, J. .s., Arnaud, N., Arun, K. .g., Ascenzi, S., Ashton, G., Ast, M., Aston, S. .m., Astone, P., Aufmuth, P., Aulbert, C., Aultoneal, K., Avila Alvarez, A., Babak, S., Bacon, P., Bader, M. .k. .m., Bae, S., Baker, P. .t., Baldaccini, F., Ballardin, G., Ballmer, S. .w., Banagiri, S., Barayoga, J. .c., Barclay, S. .e., Barish, B. .c., Barker, D., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Batch, J. .c., Baune, C., Bawaj, M., Bazzan, M., Bécsy, B., Beer, C., Bejger, M., Belahcene, I., Bell, A. .s., Berger, B. .k., Bergmann, G., Berry, C. .p. .l., Bersanetti, D., Bertolini, A., Etienne, Z. .b., Betzwieser, J., Bhagwat, S., Bhandare, R., Bilenko, I. .a., Billingsley, G., Billman, C. .r., Birch, J., Birney, R., Birnholtz, O., Biscans, S., Bisht, A., Bitossi, M., Biwer, C., Bizouard, M. .a., Blackburn, J. .k., Blackman, J., Blair, C. .d., Blair, D. .g., Blair, R. .m., Bloemen, S., Bock, O., Bode, N., Boer, M., Bogaert, G., Bohe, A., Bondu, F., Bonnand, R., Boom, B. .a., Bork, R., Boschi, V., Bose, S., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. .r., Braginsky, V. .b., BRANCHESI, MARICA, Brau, J. .e., Briant, T., Brillet, A., Brinkmann, M., Brisson, V., Brockill, P., Broida, J. .e., Brooks, A. .f., Brown, D. .a., Brown, D. .d., Brown, N. .m., Brunett, S., Buchanan, C. .c., Buikema, A., Bulik, T., Bulten, H. .j., Buonanno, A., Buskulic, D., Buy, C., Byer, R. .l., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Calderón Bustillo, J., Callister, T. .a., Calloni, E., Camp, J. .b., Canepa, M., Canizares, P., Cannon, K. .c., Cao, H., Cao, J., Capano, C. .d., Capocasa, E., Carbognani, F., Caride, S., Carney, M. .f., Casanueva Diaz, J., Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C. .b., CERBONI BAIARDI, LORENZO, Cerretani, G., Cesarini, E., Chamberlin, S. .j., Chan, M., Chao, S., Charlton, P., Chassande Mottin, E., Chatterjee, D., Cheeseboro, B. .d., Chen, H. .y., Chen, Y., Cheng, H. P., Chincarini, A., Chiummo, A., Chmiel, T., Cho, H. .s., Cho, M., Chow, J. .h., Christensen, N., Chu, Q., Chua, A. .j. .k., Chua, S., Chung, A. .k. .w., Chung, S., Ciani, G., Ciolfi, R., Cirelli, C. .e., Cirone, A., Clara, F., Clark, J. .a., Cleva, F., Cocchieri, C., Coccia, E., Cohadon, P. F., Colla, A., Collette, C. .g., Cominsky, L. .r., Constancio, M., Conti, L., Cooper, S. .j., Corban, P., Corbitt, T. .r., Corley, K. .r., Cornish, N., Corsi, A., Cortese, S., Costa, C. .a., Coughlin, M. .w., Coughlin, S. .b., Coulon, J. P., Countryman, S. .t., Couvares, P., Covas, P. .b., Cowan, E. .e., Coward, D. .m., Cowart, M. .j., Coyne, D. .c., Coyne, R., Creighton, J. .d. .e., Creighton, T. .d., Cripe, J., Crowder, S. .g., Cullen, T. .j., Cumming, A., Cunningham, L., Cuoco, E., Dal Canton, T., Danilishin, S. .l., D’Antonio, S., Danzmann, K., Dasgupta, A., Da Silva Costa, C. .f., Dattilo, V., Dave, I., Davier, M., Davies, G. .s., Davis, D., Daw, E. .j., Day, B., De, S., Debra, D., Deelman, E., Degallaix, J., De Laurentis, M., Deléglise, S., Del Pozzo, W., Denker, T., Dent, T., Dergachev, V., De Rosa, R., Derosa, R. .t., Desalvo, R., Devenson, J., Devine, R. .c., Dhurandhar, S., Díaz, M. .c., Di Fiore, L., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Di Pace, S., Di Palma, I., Di Renzo, F., Doctor, Z., Dolique, V., Donovan, F., Dooley, K. .l., Doravari, S., Dorrington, I., Douglas, R., Dovale Álvarez, M., Downes, T. .p., Drago, M., Drever, R. .w. .p., Driggers, J. .c., Du, Z., Ducrot, M., Duncan, J., Dwyer, S. .e., Edo, T. .b., Edwards, M. .c., Effler, A., Eggenstein, H. 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. j., Zhu, X. . j., Zucker, M. . e., Evans, R. . j., Laboratoire d'Annecy de Physique des Particules (LAPP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), The LIGO Scientific Collaboration, The Virgo Collaboration, and (Astro)-Particles Physics
Subjects: Physics and Astronomy (miscellaneous), Astronomy, X-ray binary, Gravitational Wave, Astrophysics, 01 natural sciences, General Relativity and Quantum Cosmology, NOISE, LIGO, 010303 astronomy & astrophysics, QC, QB, Physics, Scorpius X-1, PULSARS, Polarization (waves), Frequency domain, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], X-ray: binary, gravitational radiation: polarization, ACCRETING NEUTRON-STARS, X-RAY BINARIES, RADIATION, EMISSION, INSTABILITY, BOUNDS, Gravitational Waves, Scorpius X-1, O1, Advanced LIGO, NEUTRON-STARS, neutron star: spin, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Markov model, gravitational radiation: direct detection, O1, Pulsar, statistical analysis, 0103 physical sciences, Advanced LIGO, ddc:530, Gravitational Waves, 010308 nuclear & particles physics, Gravitational wave, gravitational radiation, 530 Physik, gravitational radiation detector, Neutron star, Physics and Astronomy, gravitational radiation: emission, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik
Abstract: Article is made available in accordance with the publisher's policy. Please refer to the publisher's site for terms of use., Results are presented from a semicoherent search for continuous gravitational waves from the brightest low-mass X-ray binary, Scorpius X-1, using data collected during the first Advanced LIGO observing run. The search combines a frequency domain matched filter (Bessel-weighted F-statistic) with a hidden Markov model to track wandering of the neutron star spin frequency. No evidence of gravitational waves is found in the frequency range 60–650 Hz. Frequentist 95% confidence strain upper limits, h95% 0 ¼ 4.0 × 10−25, 8.3 × 10−25, and 3.0 × 10−25 for electromagnetically restricted source orientation, unknown polarization, and circular polarization, respectively, are reported at 106 Hz. They are ≤ 10 times higher than the theoretical torque-balance limit at 106 Hz.
Published: 2017
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7. Search for continuous gravitational waves from neutron stars in globular cluster NGC 6544

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J., Haughian, K., Heidmann, A., Heintze, M. .c., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I. .s., Hennig, J., Henry, J., Heptonstall, A. .w., Heurs, M., Hild, S., Hoak, D., Hofman, D., Holt, K., Holz, D. .e., Hopkins, P., Hough, J., Houston, E. .a., Howell, E. .j., Hu, Y. .m., Huang, S., Huerta, E. .a., Huet, D., Hughey, B., Husa, S., Huttner, S. .h., Huynh Dinh, T., Indik, N., Ingram, D. .r., Inta, R., Isa, H. .n., Isac, J. 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M., Huerta, E. A., Huttner, S. H., Huynh-Dinh, T., Ingram, D. R., Isa, H. N., Isac, J. -M., Iyer, B. R., Jiménez-Forteza, F., Johnson, W. W., Jones, D. I., Jonker, R. J. G., Kalaghatgi, C. V., Kanner, J. B., Kapadia, S. J., Karvinen, K. S., Kehl, M. S., Kelley, D. B., Key, J. S., Khalili, F. Y., Khazanov, E. A., Kim, Chi-Woong, Kim, Y. -M., Kimbrell, S. J., King, E. J., King, P. J., Kissel, J. S., Koehlenbeck, S. M., Korth, W. Z., Kozak, D. B., Lackey, B. D., Lasky, P. D., Lebigot, E. O., Lee, C. H., Lee, H. K., Lee, H. M., Leong, J. R., Lewis, J. B., Li, T. G. F., Littenberg, T. B., Lockerbie, N. A., Lombardi, A. L., London, L. T., Lord, J. E., Lough, J. D., Lundgren, A. P., Macleod, D. M., Magaña-Sandoval, F., Magee, R. M., Mansell, G. L., Markosyan, A. S., Martelli, F., Martin, I. W., Martynov, D. V., Marx, J. N., Massinger, T. J., Masso-Reid, M., Mcclelland, D. E., Mcguire, S. C., Mcmanus, D. J., Mcwilliams, S. T., Meadors, G. D., Mercer, R. A., Merilh, E. L., Meyers, P. 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M., Silva, A. D., Singer, L. P., Sintes, A. M., Slagmolen, B. J. J., Smith, J. R., Smith, N. D., Smith, R. J. E., Son, E. J., Srivastava, A. K., Stephens, B. C., Strain, K. A., Stratta, G., Strauss, N. A., Stuver, A. L., Summerscales, T. Z., Sutton, P. J., Swinkels, B. L., Szczepańczyk, M. J., Tanner, D. B., Tarabrin, S. P., Thirugnanasambandam, M. P., Thomas, E. G., Thorne, K. A., Tokmakov, K. V., Torres, C. V., Torrie, C. I., Tringali, M. C., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Van Bakel, N., Van Beuzekom, M., Van Den Brand, J. F. J., Vander-Hyde, D. C., Van Der Schaaf, L., Van Heijningen, J. V., Van Veggel, A. A., Veitch, P. J., Vetrano, F., Viceré, A., Vine, D. J., Vinet, J. -Y., Voss, D. V., Vousden, W. D., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Ward, R. L., Wei, L. -W., Weinstein, A. J., Whelan, J. T., Whiting, B. F., Williams, R. D., Williamson, A. R., Willis, J. L., Wimmer, M. H., Wipf, C. C., Wright, J. L., Wu, D. S., Yancey, C. C., Zendri, J. -P., Zhu, X. J., Zucker, M. E., Zuraw, S. E., and (Astro)-Particles Physics
Subjects: Physics and Astronomy (miscellaneous), Astronomy, Astrophysics, 01 natural sciences, neutron stars, General Relativity and Quantum Cosmology, star: cluster, COMPANION, LIGO, neutron star, 010303 astronomy & astrophysics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), QC, media_common, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, NGC6544, NGC continuous gravitational wave sources, Star cluster, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Astrophysics - High Energy Astrophysical Phenomena, Gravitational wave, energy: conservation law, SPIN-DOWN LIMIT, DETECTOR ERA, PULSAR, EMISSION, media_common.quotation_subject, interferometer, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Astrophysics::Cosmology and Extragalactic Astrophysics, gravitational radiation: direct detection, O1, Gravitational waves, Pulsar, Gravitational waves, neutron stars, NGC6544, O1, 0103 physical sciences, ddc:530, SDG 7 - Affordable and Clean Energy, Astrophysics::Galaxy Astrophysics, 010308 nuclear & particles physics, gravitational radiation, 530 Physik, gravitational radiation detector, Stars, Neutron star, VIRGO, Physics and Astronomy, Sky, Globular cluster, gravitational radiation: emission, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: We describe a directed search for continuous gravitational waves in data from the sixth LIGO science run. The target was the nearby globular cluster NGC 6544 at a distance of 2.7 kpc. The search covered a broad band of frequencies along with first and second frequency derivatives for a fixed sky position. The search coherently integrated data from the two LIGO interferometers over a time span of 9.2 days using the matched-filtering F-statistic. We found no gravitational-wave signals and set 95% confidence upper limits as stringent as 6.0 X 10^{-25} on intrinsic strain and 8.5 X 10^{-6} on fiducial ellipticity. These values beat the indirect limits from energy conservation for stars with characteristic spindown ages older than 300 years and are within the range of theoretical predictions for possible neutron-star ellipticities. An important feature of this search was use of a barycentric resampling algorithm which substantially reduced computational cost; this method will be used extensively in searches of Advanced LIGO and Virgo detector data., Comment: 15 pages, 4 figures
Published: 2017
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8. First Search for Gravitational Waves from Known Pulsars with Advanced LIGO

Author: Abbott, and Abbott, B. P., and Abbott, R., and Abernathy, T. D., and Acernese, M. R., and Ackley, F., and Adams, K., and Adams, C., and Addesso, T., and Adhikari, P., and Adya, R. X., and Affeldt, V. B., and Agathos, C., and Agatsuma, M., and Aggarwal, K., and Aguiar, N., and Aiello, O. D., and Ain, L., and Ajith, A., and Allen, P., and Allocca, B., and Altin, A., and Ananyeva, P. A., and Anderson, A., and Anderson, S. B., and Appert, W. G., and Arai, S., and Araya, K., and Areeda, M. C., and Arnaud, J. S., and Arun, N., and Ascenzi, K. G., and Ashton, S., and Ast, G., and Aston, M., and Astone, S. M., and Aufmuth, P., and Aulbert, P., and Avila-Alvarez, C., and Babak, A., and Bacon, S., and Bader, P., and Baker, M. K. M., and Baldaccini, P. T., and Ballardin, F., and Ballmer, G., and Barayoga, S. W., and Barclay, J. C., and Barish, S. E., and Barker, B. C., and Barone, D., and Barr, F., and Barsotti, B., and Barsuglia, L., and Barta, M., and Bartlett, D., and Bartos, J., and Bassiri, I., and Basti, R., and Batch, A., and Baune, J. C., and Bavigadda, C., and Bazzan, V., and Beer, M., and Bejger, C., and Belahcene, M., and Belgin, I., and Bell, M., and Berger, A. S., and Bergmann, B. K., and Berry, G., and Bersanetti, C. P. L., and Bertolini, D., and Betzwieser, A., and Bhagwat, J., and Bhandare, S., and Bilenko, R., and Billingsley, I. A., and Billman, G., and Birch, C. R., and Birney, J., and Birnholtz, R., and Biscans, O., and Bisht, S., and Bitossi, A., and Biwer, M., and Bizouard, C., and Blackburn, M. A., and Blackman, J. K., and Blair, J., and Blair, C. D., and Blair, D. G., and Bloemen, R. M., and Bock, S., and Boer, O., and Bogaert, M., and Bohe, G., and Bondu, A., and Bonnand, F., and Boom, R., and Bork, B. A., and Boschi, R., and Bose, V., and Bouffanais, S., and Bozzi, Y., and Bradaschia, A., and Brady, C., and Braginsky, P. R., and Branchesi, V. B., and Brau, M., and Briant, J. E., and Brillet, T., and Brinkmann, A., and Brisson, M., and Brockill, V., and Broida, P., and Brooks, J. E., and Brown, A. F., and Brown, D. A., and Brown, D. D., and Brunett, N. M., and Buchanan, S., and Buikema, C. C., and Bulik, A., and Bulten, T., and Buonanno, H. J., and Buskulic, A., and Buy, D., and Byer, C., and Cabero, R. L., and Cadonati, M., and Cagnoli, L., and Cahillane, G., and Bustillo, C., Calderon and Callister, J., and Calloni, T. A., and Camp, E., and Canepa, J. B., and Cannon, M., and Cao, K. C., and Cao, H., and Capano, J., and Capocasa, C. D., and Carbognani, E., and Caride, F., and Diaz, S., Casanueva and Casentini, J., and Caudill, C., and Cavaglia, S., and Cavalier, M., and Cavalieri, F., and Cella, R., and Cepeda, G., and Baiardi, C. 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W., Weltevrede, P., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for Gravitational Physics (Albert Einstein Institute) (AEI), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Max Delbrück Center for Molecular Medicine [Berlin] (MDC), Helmholtz-Gemeinschaft = Helmholtz Association, Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Department of Physics, Columbia University [New York], Dipartimento di Physica E. Firmi, University of Pisa - Università di Pisa, Copernicus Astronomical Center of the Polish Academy of Sciences (CAMK), Polish Academy of Sciences (PAN), Instituut voor Sterrenkunde [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Observatoire de Haute-Provence (OHP), Institut Pythéas (OSU PYTHEAS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Kastler Brossel (LKB (Jussieu)), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Sadron (ICS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Physics Department, University of Massachusetts System (UMASS), APC - Gravitation (APC-Gravitation), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Department of Earth and Space Science and Engineering [York University - Toronto] (ESSE), York University [Toronto], Laboratoire Kastler Brossel (LKB (Lhomond)), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), European Organization for Nuclear Research (CERN), School of Mathematics [Cardiff], Cardiff University, Université de Rennes (UR), Dipartimento di Fisica [Parma], Università degli studi di Parma = University of Parma (UNIPR), Indian Institute of Technology Kanpur (IIT Kanpur), Bayerische Julius-Maximilians University, Department of Mechanical Engineering, University of California [Santa Barbara] (UC Santa Barbara), University of California (UC)-University of California (UC), Tata Institute for Fundamental Research (TIFR), Erlangen Centre for Astroparticle Physics (ECAP), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Institut de Recherches Subatomiques (IReS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Centre National de la Recherche Scientifique (CNRS), Institute for Plasma Research, Bhat, Gandhinagar India, DLR Institut für Physik der Atmosphäre (IPA), Deutsches Zentrum für Luft- und Raumfahrt [Oberpfaffenhofen-Wessling] (DLR), Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Unité Scientifique de la Station de Nançay (USN), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), SFA Inc/NRL (SFA INC/NRL), SFA Inc/NRL, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Pierre et Marie Curie - Paris 6 (UPMC)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Université de Rennes (UNIV-RENNES), University of Parma = Università degli studi di Parma [Parme, Italie], University of California [Santa Barbara] (UCSB), University of California-University of California, Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), The LIGO Scientific Collaboration, The Virgo Collaboration, (Astro)-Particles Physics, Branchesi, M., Calloni, Enrico, Baiardi, L. Cerboni, DE LAURENTIS, Martina, DE ROSA, Rosario, DI GIROLAMO, Tristano, Garufi, Fabio, Greco, G., Guidi, G. M., Harms, J., Martelli, F., Milano, Leopoldo, Montani, M., Piergiovanni, F., Stratta, G., Vetrano, F., Viceré, A., Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Albert Einstein Institute, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Max-Delbrück-Center for Molecular Medicine (MDC), Center for Molecular Medicine, Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Centre National de la Recherche Scientifique (CNRS), Università degli studi di Parma [Parme, Italie], Tata Institute of Fundamental Research [Bombay] (TIFR), PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université d'Orléans (UO)-Observatoire des Sciences de l'Univers en région Centre (OSUC), PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Centre National d’Études Spatiales [Paris] (CNES), PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Max Planck Institut für Gravitationsphysik, Albert Einstein Institut, Albert Einstein Institut, Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Max-Delbrück-Center for Molecular Medicine ( MDC ), Physique Corpusculaire et Cosmologie - Collège de France ( PCC ), Collège de France ( CdF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Universite di Pisa, N. Copernicus Astronomical Center, Polska Akademia Nauk ( PAN ), Instituut voor Sterrenkunde ( INSTITUUT VOOR STERRENKUNDE ), Université Catholique de Louvain ( UCL ), Observatoire de Haute-Provence ( OHP ), Institut Pythéas ( OSU PYTHEAS ), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Institut d'Astrophysique de Paris ( IAP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Physique de Rennes ( IPR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des matériaux avancés ( LMA ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Kastler Brossel ( LKB (Jussieu) ), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris ( FRDPENS ), Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Charles Sadron ( ICS ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ) -Matériaux et nanosciences d'Alsace, Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Réseau nanophotonique et optique, Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ), Copernicus Astronomical Center of the Polish Academy of Sciences ( CAMK ), Polish Academy of Sciences ( PAN ), University of Massachusetts, APC - Gravitation ( APC-Gravitation ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Max-Planck-Institut-Max-Planck-Institut, Department of Earth and Space Science and Engineering [Toronto] ( ESSE ), Laboratoire Kastler Brossel ( LKB (Lhomond) ), Observatoire de la Côte d'Azur ( OCA ), Centre National de la Recherche Scientifique ( CNRS ), European Organization for Nuclear Research ( CERN ), Cardiff School of Mathematics, Université de Rennes ( UNIV-RENNES ), Dipartimento di Fisica,Universita` di Parma, INFM and CNISM, Università degli studi di Parma, Indian Institute of Technology [Kanpur] ( IIT ), University of California [Santa Barbara], Center for Geophysical Investigation of the Shallow Subsurface ( Department of Geosciences ), Department of Geoscience, Erlangen Centre for Astroparticle Physics ( ECAP ), Friedrich-Alexander Universität Erlangen-Nürnberg ( FAU ), Institut de Recherches Subatomiques ( IReS ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Cancéropôle du Grand Est-Centre National de la Recherche Scientifique ( CNRS ), DLR Institut für Physik der Atmosphäre ( IPA ), Deutsches Zentrum für Luft- und Raumfahrt [Oberpfaffenhofen-Wessling] ( DLR ), Laboratoire de Physique et Chimie de l'Environnement et de l'Espace ( LPC2E ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ), Unité Scientifique de la Station de Nançay ( USN ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ), CALTECH, Louisiana State Univ, Amer Univ, Univ Salerno, Complesso Univ Monte S Angelo, Univ Florida, LIGO Livingston Observ, Univ Savoie Mt Blanc, Univ Sannio Benevento, INFN, Max Planck Inst Gravitat Phys, Nikhef, MIT, Inst Nacl Pesquisas Espaciais, Interuniv Ctr Astron & Astrophys, Tata Inst Fundamental Res, Univ Wisconsin Milwaukee, Leibniz Univ Hannover, Univ Pisa, Australian Natl Univ, Calif State Univ Fullerton, Univ Paris 11, Chennai Math Inst, Univ Roma Tor Vergata, Univ Hamburg, Universidade de São Paulo (USP), West Virginia Univ, Univ Perugia, EGO, Syracuse Univ, Univ Glasgow, LIGO Hanford Observ, RMKI, Columbia Univ, Stanford Univ, Univ Padua, Polish Acad Sci, Georgia Inst Technol, Univ Birmingham, Univ Genoa, RRCAT, Lomonosov Moscow State Univ, Univ West Scotland, Caltech CaRT, Univ Western Australia, Radboud Univ Nijmegen, Univ Cote Dazur, Univ Rennes 1, Washington State Univ, Univ Urbino Carlo Bo, Univ Oregon, UPMC, Carleton Coll, Warsaw Univ, Vrije Univ Amsterdam, Univ Maryland, CNRS, Univ Claude Bernard Lyon 1, Univ Napoli Federico II, NASA, Univ Tokyo, Univ Adelaide, Tsinghua Univ, Texas Tech Univ, Univ Mississippi, Penn State Univ, Natl Tsing Hua Univ, Charles Sturt Univ, Univ Chicago, Kenyon Coll, Korea Inst Sci & Technol Informat, Univ Cambridge, Univ Roma La Sapienza, Univ Brussels, Sonoma State Univ, Montana State Univ, Northwestern Univ, Univ Illes Balears, Univ Texas Rio Grande Valley, Bellevue Coll, Inst Plasma Res, Univ Sheffield, Calif State Univ Los Angeles, Univ Trento, Cardiff Univ, Montclair State Univ, Natl Astron Observ Japan, Univ Toronto, MTA Eotvos Univ, Univ Edinburgh, Univ & Inst Adv Res, IISER TVM, Univ Szeged, Embry Riddle Aeronaut Univ, INAF, Univ Michigan, Rochester Inst Technol, Univ Illinois, Univ Bialystok, Univ Strathclyde, Univ Southampton, Univ Washington Bothell, Inst Appl Phys, Seoul Natl Univ, Inje Univ Gimhae, Natl Inst Math Sci, Pusan Natl Univ, NCBJ, Monash Univ, Hanyang Univ, Chinese Univ Hong Kong, Univ Alabama Huntsville, Univ Minnesota, Univ Camerino, Southern Univ, A&M Coll, Univ Melbourne, Coll William & Mary, Universidade Estadual Paulista (Unesp), Whitman Coll, Univ Lyon, Hobart & William Smith Colleges, Univ Zielona Gora, Univ London, IISER Kolkata, Indian Inst Technol, Andrews Univ, Univ Siena, Trinity Univ, Univ Washington, Abilene Christian Univ, Sq Kilometer Array South Africa, Hartebeesthoek Radio Astron Observ, Univ Orleans, Max Planck Inst Radioastron, Australia Telescope Natl Facil, Univ Manchester, and Curtin Univ
Subjects: Astronomy, Gravitational Wave, Astrophysics, 01 natural sciences, general [pulsars], machine [Supporting material], General Relativity and Quantum Cosmology, DOWN LIMIT, gravitational waves, pulsars: general, Limit (mathematics), 010303 astronomy & astrophysics, POPULATION, QC, QB, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, [PHYS]Physics [physics], [ PHYS ] Physics [physics], GLOBULAR-CLUSTER, WIND TORI, Detector, Amplitude, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Astrophysics - High Energy Astrophysical Phenomena, GAMMA-RAY PULSARS, NEUTRON-STARS, gr-qc, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), O1, Supporting material: machine, Pulsar, SPIN-DOWN LIMIT, readable table, 0103 physical sciences, GAMMA-RAY PULSAR, STFC, Pulsars, PULSATIONS, 010308 nuclear & particles physics, Gravitational wave, RCUK, Astronomy and Astrophysics, Space and Planetary Science, LIGO, PROSPECTS, SPINNING NEUTRON-STARS, Physics and Astronomy, EMISSION, DISTANCE, aLIGO, Gravitational Waves, O1, aLIGO, Pulsars, CLUSTERS
Abstract: An erratum for this article has been published in 2017 ApJ 851 71, We present the result of searches for gravitational waves from 200 pulsars using data from the first observing run of the Advanced LIGO detectors. We find no significant evidence for a gravitational-wave signal from any of these pulsars, but we are able to set the most constraining upper limits yet on their gravitational-wave amplitudes and ellipticities. For eight of these pulsars, our upper limits give bounds that are improvements over the indirect spin-down limit values. For another 32, we are within a factor of 10 of the spin-down limit, and it is likely that some of these will be reachable in future runs of the advanced detector. Taken as a whole, these new results improve on previous limits by more than a factor of two.
Published: 2017
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9. Search for intermediate mass black hole binaries in the first observing run of Advanced LIGO

Author: Abbott, and Abbott, B. P., and Abbott, R., and Acernese, T. D., and Ackley, F., and Adams, K., and Adams, C., and Addesso, T., and Adhikari, P., and Adya, R. X., and Affeldt, V. B., and Afrough, C., and Agarwal, M., and Agatsuma, B., and Aggarwal, K., and Aguiar, N., and Aiello, O. D., and Ain, L., and Allen, A., and Allen, B., and Allocca, G., and Almoubayyed, A., and Altin, H., and Amato, P. A., and Ananyeva, A., and Anderson, A., and Anderson, S. B., and Antier, W. G., and Appert, S., and Arai, S., and Araya, K., and Areeda, M. C., and Arnaud, J. S., and Arun, N., and Ascenzi, K. G., and Ashton, S., and Ast, G., and Aston, M., and Astone, S. M., and Aufmuth, P., and Aulbert, P., and AultONeal, C., and Avila-Alvarez, K., and Babak, A., and Bacon, S., and Bader, P., and Bae, M. K. M., and Baker, S., and Baldaccini, P. T., and Ballardin, F., and Ballmer, G., and Banagiri, S. W., and Barayoga, S., and Barclay, J. C., and Barish, S. E., and Barker, B. C., and Barone, D., and Barr, F., and Barsotti, B., and Barsuglia, L., and Barta, M., and Bartlett, D., and Bartos, J., and Bassiri, I., and Basti, R., and Batch, A., and Baune, J. C., and Bawaj, C., and Bazzan, M., and Becsy, M., and Beer, B., and Bejger, C., and Belahcene, M., and Bell, I., and Berger, A. S., and Bergmann, B. K., and Bell, G., and Berry, G., and Bersanetti, C. P. L., and Bertolini, D., and Betzwieser, A., and Bhagwat, J., and Bhandare, S., and Bilenko, R., and Billingsley, I. A., and Billman, G., and Birch, C. R., and Birney, J., and Birnholtz, R., and Biscans, O., and Bisht, S., and Bitossi, A., and Biwer, M., and Bizouard, C., and Blackburn, M. A., and Blackman, J. K., and Blair, J., and Blair, C. D., and Blair, D. G., and Bloemen, R. M., and Bock, S., and Bode, O., and Boer, N., and Bogaert, M., and Bohe, G., and Bondu, A., and Bonnand, F., and Boom, R., and Bork, B. A., and Boschi, R., and Bose, V., and Bouffanais, S., and Bozzi, Y., and Bradaschia, A., and Brady, C., and Braginsky, P. R., and Branchesi, V. B., and Brau, M., and Briant, J. E., and Brillet, T., and Brinkmann, A., and Brisson, M., and Brockill, V., and Broida, P., and Brooks, J. E., and Brown, A. F., and Brown, D. A., and Brown, D. D., and Brunett, N. M., and Buchanan, S., and Buikema, C. C., and Bulik, A., and Bulten, T., and Buonanno, H. J., and Buskulic, A., and Buy, D., and Byer, C., and Cabero, R. L., and Cadonati, M., and Cagnoli, L., and Cahillane, G., and Bustillo, C., Calderon and Callister, J., and Calloni, T. A., and Camp, E., and Canepa, J. B., and Canizares, M., and Cannon, P., and Cao, K. C., and Cao, H., and Capano, J., and Capocasa, C. D., and Carbognani, E., and Caride, F., and Carney, S., and Diaz, M. F., Casanueva and Casentini, J., and Caudill, C., and Cavaglia, S., and Cavalier, M., and Cavalieri, F., and Cella, R., and Cepeda, G., and Baiardi, C. 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j., Tacca, M., Talukder, D., Tanner, D. . b., Tápai, M., Taracchini, A., Taylor, J. . a., Taylor, R., Theeg, T., Thomas, E. . g., Thomas, M., Thomas, P., Thorne, K. . a., Thorne, K. . s., Thrane, E., Tiwari, S., Tiwari, V., Tokmakov, K. . v., Toland, K., Tonelli, M., Tornasi, Z., Torrie, C. . i., Töyrä, D., Travasso, F., Traylor, G., Trifirò, D., Trinastic, J., Tringali, M. . c., Trozzo, L., Tsang, K. . w., Tse, M., Tso, R., Tuyenbayev, D., Ueno, K., Ugolini, D., Unnikrishnan, C. . s., Urban, A. . l., Usman, S. . a., Vahi, K., Vahlbruch, H., Vajente, G., Valdes, G., van Bakel, N., van Beuzekom, M., van den Brand, J. . f. . j., Van Den Broeck, C., Vander Hyde, D. . c., van der Schaaf, L., van Heijningen, J. . v., van Veggel, A. . a., Vardaro, M., Varma, V., Vass, S., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. . j., Venkateswara, K., Venugopalan, G., Verkindt, D., Vetrano, F., Viceré, A., Viets, A. . d., Vinciguerra, S., Vine, D. . j., Vinet, J. Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Voss, D. . v., Vousden, W. . d., Vyatchanin, S. . p., Wade, A. . r., Wade, L. . e., Wade, M., Walet, R., Walker, M., Wallace, L., Walsh, S., Wang, G., Wang, H., Wang, J. . z., Wang, M., Wang, Y. F., Wang, Y., Ward, R. . l., Warner, J., Was, M., Watchi, J., Weaver, B., Wei, L. W., Weinert, M., Weinstein, A. . j., Weiss, R., Wen, L., Wessel, E. . k., Weßels, P., Westphal, T., Wette, K., Whelan, J. . t., Whiting, B. . f., Whittle, C., Williams, D., Williams, R. . d., Williamson, A. . r., Willis, J. . l., Willke, B., Wimmer, M. . h., Winkler, W., Wipf, C. . c., Wittel, H., Woan, G., Woehler, J., Wofford, J., Wong, K. . w. . k., Worden, J., Wright, J. . l., Wu, D. . s., Wu, G., Yam, W., Yamamoto, H., Yancey, C. . c., Yap, M. . j., Yu, Hang, Yu, Haocun, Yvert, M., Zadrożny, A., Zanolin, M., Zelenova, T., Zendri, J. P., Zevin, M., Zhang, L., Zhang, M., Zhang, T., Zhang, Y. H., Zhao, C., Zhou, M., Zhou, Z., Zhu, X. . j., Zucker, M. . e., Zweizig, J., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Kastler Brossel (LKB [Collège de France]), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), LIGO Scientific, Virgo, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), (Astro)-Particles Physics, Abbott, B. .p., Abbott, T. .d., Adhikari, R. .x., Adya, V. .b., Aguiar, O. .d., Altin, P. .a., Anderson, S. .b., Anderson, W. .g., Araya, M. .c., Areeda, J. .s., Arun, K. .g., Aston, S. .m., Bader, M. .k. .m., Baker, P. .t., Ballmer, S. .w., Barayoga, J. .c., Barclay, S. .e., Barish, B. .c., Batch, J. .c., Bell, A. .s., Berger, B. .k., Berry, C. .p. .l., Bilenko, I. .a., Billman, C. .r., Bizouard, M. .a., Blackburn, J. .k., Blair, C. .d., Blair, D. .g., Blair, R. .m., Boom, B. .a., Brady, P. .r., Braginsky, V. .b., BRANCHESI, MARICA, Brau, J. .e., Broida, J. .e., Brooks, A. .f., Brown, D. .a., Brown, D. .d., Brown, N. .m., Buchanan, C. .c., Bulten, H. .j., Byer, R. .l., Callister, T. .a., Calloni, E., Camp, J. .b., Cannon, K. .c., Capano, C. .d., Carney, M. .f., Cepeda, C. .b., CERBONI BAIARDI, LORENZO, Chamberlin, S. .j., Cheeseboro, B. .d., Chen, H. .y., Cho, H. .s., Chow, J. .h., Chua, A. .j. .k., Chung, A. .k. .w., Cirelli, C. .e., Clark, J. .a., Collette, C. .g., Cominsky, L. .r., Cooper, S. .j., Corbitt, T. .r., Corley, K. .r., Costa, C. .a., Coughlin, M. .w., Coughlin, S. .b., Countryman, S. .t., Covas, P. .b., Cowan, E. .e., Coward, D. .m., Cowart, M. .j., Coyne, D. .c., Creighton, J. .d. .e., Creighton, T. .d., Crowder, S. .g., Cullen, T. .j., Danilishin, S. .l., Da Silva Costa, C. .f., Davies, G. .s., Daw, E. .j., De Laurentis, M., De Rosa, R., Derosa, R. .t., Devine, R. .c., Díaz, M. .c., Di Girolamo, T., Dooley, K. .l., Downes, T. .p., Drever, R. .w. .p., Driggers, J. .c., Dwyer, S. .e., Edo, T. .b., Edwards, M. .c., Eikenberry, S. .s., Eisenstein, R. .a., Essick, R. .c., Evans, T. .m., Farr, W. .m., Fauchon Jones, E. .j., Fejer, M. .m., Ferreira, E. .c., Fisher, R. .p., Forsyth, P. .w. .f., Forsyth, S. .s., Fries, E. .m., Frolov, V. .v., Gadre, B. .u., Gaebel, S. .m., Gair, J. .r., Ganija, M. .r., Gaonkar, S. .g., Garufi, F., Giaime, J. .a., Giardina, K. .d., Gonzalez Castro, J. .m., Gorodetsky, M. .l., Gossan, S. .e., GRECO, GIUSEPPE, Green, A. .c., GUIDI, GIANLUCA MARIA, Gupta, M. .k., Gushwa, K. .e., Gustafson, E. .k., Hall, B. .r., Hall, E. .d., Hanke, M. .m., Hannam, M. .d., Hannuksela, O. .a., HARMS, JAN, Harry, G. .m., Harry, I. .w., Hart, M. .j., Heintze, M. .c., Heng, I. .s., Heptonstall, A. .w., Holz, D. .e., Houston, E. .a., Howell, E. .j., Hu, Y. .m., Huerta, E. .a., Huttner, S. .h., Ingram, D. .r., Isa, H. .n., Iyer, B. .r., Johnson, W. .w., Jones, D. .i., Jonker, R. .j. .g., Kalaghatgi, C. .v., Kanner, J. .b., Karvinen, K. .s., Kemball, A. .j., Key, J. .s., Khalili, F. .y., Khazanov, E. .a., Kim, J. .c., Kim, W. .s., Kimbrell, S. .j., King, E. .j., King, P. .j., Kissel, J. .s., Koehlenbeck, S. .m., Korth, W. .z., Kozak, D. .b., Lackey, B. .d., Lai, K. .h., Lang, R. .n., Lanza, R. .k., Lasky, P. .d., Lee, C. .h., Lee, H. .k., Lee, H. .m., Lee, H. .w., Li, T. .g. .f., Littenberg, T. .b., Lockerbie, N. .a., London, L. .t., Lord, J. .e., Lough, J. .d., Lousto, C. .o., Lundgren, A. .p., Macleod, D. .m., Magee, R. .m., Mansell, G. .l., Markosyan, A. .s., MARTELLI, FILIPPO, Martin, I. .w., Martynov, D. .v., Marx, J. .n., Massinger, T. .j., Mcclelland, D. .e., Mcguire, S. .c., Mcmanus, D. .j., Mcwilliams, S. .t., Meadors, G. .d., Mercer, R. .a., Merilh, E. .l., Meyers, P. .m., Mikhailov, E. .e., Milano, L., Miller, A. .l., Miller, B. .b., Mitrofanov, V. .p., Mohapatra, S. .r. .p., MONTANI, MATTEO, Moore, B. .c., Moore, C. .j., Morriss, S. .r., Mow Lowry, C. .m., Muir, A. .w., Muniz, E. .a. .m., Murray, P. .g., Nayak, R. .k., Nelson, T. .j. .n., Newport, J. .m., Ng, K. .k. .y., Nguyen, T. .t., Nielsen, A. .b., Normandin, M. .e. .n., Nuttall, L. .k., Ogin, G. .h., Oh, J. .j., Oh, S. .h., Ortega, L. .f., Ottaway, D. .j., Owen, B. .j., Pace, A. .e., Page, M. .a., Pai, S. .a., Palamos, J. .r., Pang, P. .t. .h., Pant, B. .c., Papa, M. .a., Paris, H. .r., Pearlstone, B. .l., Perez, C. .j., Perri, L. .m., Pfeiffer, H. .p., Piccinni, O. .j., PIERGIOVANNI, FRANCESCO, Pinto, I. .m., Porter, E. .k., Pratt, J. .w. .w., Prodi, G. .a., Prokhorov, L. .g., Quintero, E. .a., Raab, F. .j., Rabeling, D. .s., Ramirez, K. .e., Reitze, D. .h., Reyes, S. .d., Ricker, P. .m., Robertson, N. .a., Rollins, J. .g., Roma, V. .j., Romel, C. .l., Romie, J. .h., Ross, M. .p., Sampson, L. .m., Sanchez, E. .j., Sanders, J. .r., Sathyaprakash, B. .s., Saulson, P. .r., Savage, R. .l., Schofield, R. .m. .s., Schulte, B. .w., Schutz, B. .f., Schwalbe, S. .g., Scott, S. .m., Sengupta, A. .s., Shaddock, D. .a., Shaffer, T. .j., Shah, A. .a., Shahriar, M. .s., Shoemaker, D. .h., Shoemaker, D. .m., Silva, A. .d., Singer, L. .p., Sintes, A. .m., Slagmolen, B. .j. .j., Smith, J. .r., Smith, R. .j. .e., Son, E. .j., Sonnenberg, J. .a., Spencer, A. .p., Srivastava, A. .k., Stephens, B. .c., Strain, K. .a., STRATTA, MARIA GIULIANA, Strigin, S. .e., Stuver, A. .l., Summerscales, T. .z., Sutton, P. .j., Swinkels, B. .l., Szczepańczyk, M. .j., Tanner, D. .b., Taylor, J. .a., Thomas, E. .g., Thorne, K. .a., Thorne, K. .s., Tokmakov, K. .v., Torrie, C. .i., Tringali, M. .c., Tsang, K. .w., Unnikrishnan, C. .s., Urban, A. .l., Usman, S. .a., van den Brand, J. .f. .j., Vander Hyde, D. .c., van Heijningen, J. .v., van Veggel, A. .a., Veitch, P. .j., VETRANO, FLAVIO, VICERE', ANDREA, Viets, A. .d., Vine, D. .j., Voss, D. .v., Vousden, W. .d., Vyatchanin, S. .p., Wade, A. .r., Wade, L. .e., Wang, J. .z., Ward, R. .l., Weinstein, A. .j., Wessel, E. .k., Whelan, J. .t., Whiting, B. .f., Williams, R. .d., Williamson, A. .r., Willis, J. .l., Wimmer, M. .h., Wipf, C. .c., Wong, K. .w. .k., Wright, J. .l., Wu, D. .s., Yancey, C. .c., Yap, M. .j., Zhu, X. .j., and Zucker, M. .e.
Subjects: Physics and Astronomy (miscellaneous), Astronomy, Gravitational Wave, Binary number, Astrophysics, 01 natural sciences, General Relativity and Quantum Cosmology, star, jet, clusters, LIGO, 010303 astronomy & astrophysics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), QC, 97.60.Lf, QB, candidate, Physics, black hole: spin, 04.25.dg, 04.30.-w, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], mergers, Angular momentum, coalescences, Astrophysics::High Energy Astrophysical Phenomena, IMBH, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Astrophysics::Cosmology and Extragalactic Astrophysics, gravitational radiation: direct detection, angular momentum, O1, Intermediate BH search, Binary black hole, 0103 physical sciences, Binary star, gravitational radiation: burst, ddc:530, Gravitational Waves, 010308 nuclear & particles physics, Gravitational wave, gravitational radiation, black hole: mass, Gravitational Waves, LIGO, O1, IMBH, 530 Physik, 04.80.Nn, gravitational radiation detector, detector: sensitivity, Physics and Astronomy, Orders of magnitude (time), black hole: binary, Intermediate-mass black hole, gravitational radiation: emission, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, limits, gravitational-waves
Abstract: During their first observational run, the two Advanced LIGO detectors attained an unprecedented sensitivity, resulting in the first direct detections of gravitational-wave signals and GW151226, produced by stellar-mass binary black hole systems. This paper reports on an all-sky search for gravitational waves (GWs) from merging intermediate mass black hole binaries (IMBHBs). The combined results from two independent search techniques were used in this study: the first employs a matched-filter algorithm that uses a bank of filters covering the GW signal parameter space, while the second is a generic search for GW transients (bursts). No GWs from IMBHBs were detected, therefore, we constrain the rate of several classes of IMBHB mergers. The most stringent limit is obtained for black holes of individual mass $100\,M_\odot$, with spins aligned with the binary orbital angular momentum. For such systems, the merger rate is constrained to be less than $0.93~\mathrm{Gpc^{-3}\,yr}^{-1}$ in comoving units at the $90\%$ confidence level, an improvement of nearly 2 orders of magnitude over previous upper limits., 8 pages, 2 figures
Published: 2017
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10. Estimating the Contribution of Dynamical Ejecta in the Kilonova Associated with GW170817

Author: Abbott, and Abbott, B. P., and Abbott, R., and Acernese, T. D., and Ackley, F., and Adams, K., and Adams, C., and Addesso, T., and Adhikari, P., and Adya, R. X., and Affeldt, V. B., and Afrough, C., and Agarwal, M., and Agathos, B., and Agatsuma, M., and Aggarwal, K., and Aguiar, N., and Aiello, O. D., and Ain, L., and Ajith, A., and Allen, P., and Allen, B., and Allocca, G., and Altin, A., and Amato, P. A., and Ananyeva, A., and Anderson, A., and Anderson, S. B., and Angelova, W. G., and Antier, S. V., and Appert, S., and Arai, S., and Araya, K., and Areeda, M. C., and Arnaud, J. S., and Arun, N., and Ascenzi, K. G., and Ashton, S., and Ast, G., and Aston, M., and Astone, S. M., and Atallah, P., and Aufmuth, D. V., and Aulbert, P., and AultONeal, C., and Austin, K., and Avila-Alvarez, C., and Babak, A., and Bacon, S., and Bader, P., and Bae, M. K. M., and Baker, S., and Baldaccini, P. T., and Ballardin, F., and Banagiri, G., and Barayoga, S., and Barclay, J. C., and Barish, S. E., and Barker, B. C., and Barkett, D., and Barone, K., and Barr, F., and Barsotti, B., and Barsuglia, L., and Barta, M., and Bartlett, D., and Bartos, J., and Bassiri, I., and Basti, R., and Batch, A., and Bawaj, J. C., and Bayley, M., and Bazzan, J. C., and Becsy, M., and Beer, B., and Bejger, C., and Belahcene, M., and Bell, I., and Bergmann, A. S., and Bernuzzi, G., and Bero, S., and Berry, J. J., and Bersanetti, C. P. L., and Bertolini, D., and Betzwieser, A., and Bhagwat, J., and Bhandare, S., and Bilenko, R., and Billingsley, I. A., and Billman, G., and Birch, C. R., and Birney, J., and Birnholtz, R., and Biscans, O., and Biscoveanu, S., and Bisht, S., and Bitossi, A., and Biwer, M., and Bizouard, C., and Blackburn, M. A., and Blackman, J. K., and Blair, J., and Blair, C. D., and Blair, D. G., and Bloemen, R. M., and Bock, S., and Bode, O., and Boer, N., and Bogaert, M., and Bohe, G., and Bondu, A., and Bonilla, F., and Bonnand, E., and Boom, R., and Bork, B. A., and Boschi, R., and Bose, V., and Bossie, S., and Bouffanais, K., and Bozzi, Y., and Bradaschia, A., and Brady, C., and Branchesi, P. R., and Brau, M., and Briant, J. E., and Brillet, T., and Brinkmann, A., and Brisson, M., and Brockill, V., and Broida, P., and Brooks, J. E., and Brown, A. F., and Brunett, D. D., and Buchanan, S., and Buikema, C. C., and Bulik, A., and Bulten, T., and Buonanno, H. J., and Buskulic, A., and Buy, D., and Byer, C., and Cabero, R. L., and Cadonati, M., and Cagnoli, L., and Cahillane, G., and Bustillo, C., Calderon and Callister, J., and Calloni, T. A., and Camp, E., and Canepa, J. B., and Canizares, M., and Cannon, P., and Cao, K. C., and Cao, H., and Capano, J., and Capocasa, C. D., and Carbognani, E., and Caride, F., and Carney, S., and Diaz, M. F., Casanueva and Casentini, J., and Caudill, C., and Cavaglia, S., and Cavalier, M., and Cavalieri, F., and Cella, R., and Cepeda, G., and Cerda-Duran, C. B., and Cerretani, P., and Cesarini, G., and Chamberlin, E., and Chan, S. J., and Chao, M., and Charlton, S., and Chase, P., and Chassande-Mottin, E., and Chatterjee, E., and Chatziioannou, D., and Cheeseboro, K., and Chen, B. D., and Chen, H. Y., and Chen, X., and Cheng, Y., and Chia, H. -. P., and Chincarini, H., and Chiummo, A., and Chmiel, A., and Cho, T., and Cho, H. S., and Chow, M., and Christensen, J. H., and Chu, N., and Chua, Q., and Chua, A. J. K., and Chung, S., and Chung, A. K. W., and Ciani, S., and Ciolfi, G., and Cirelli, R., and Cirone, C. E., and Clara, A., and Clark, F., and Clearwater, J. A., and Cleva, P., and Cocchieri, F., and Coccia, C., and Cohadon, E., and Cohen, P. -. F., and Colla, D., and Collette, A., and Cominsky, C. G., and Constancio, L. R., J. r., and Conti, M., and Cooper, L., and Corban, S. J., and Corbitt, P., and Cordero-Carrion, T. R., and Corley, I., and Cornish, K. R., and Corsi, N., and Cortese, A., and Costa, S., and Coughlin, C. 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C., and Di Fiore, T., and Di Giovanni, L., and Di Girolamo, M., and Di Lieto, T., and Di Pace, A., and Di Palma, S., and Di Renzo, I., and Doctor, F., and Dolique, Z., and Donovan, V., and Dooley, F., and Doravari, K. L., and Dorrington, S., and Douglas, I., and Alvarez, R., Dovale and Downes, M., and Drago, T. P., and Dreissigacker, M., and Driggers, C., and Du, J. C., and Ducrot, Z., and Dupej, M., and Dwyer, P., and Edo, S. E., and Edwards, T. B., and Effler, M. C., and Eggenstein, A., and Ehrens, H. -. B., and Eichholz, P., and Eikenberry, J., and Eisenstein, S. S., and Essick, R. A., and Estevez, R. C., and Etienne, D., and Etzel, Z. B., and Evans, T., and Evans, M., and Factourovich, T. M., and Fafone, M., and Fair, V., and Fairhurst, H., and Fan, S., and Farinon, X., and Farr, S., and Farr, B., and Fauchon-Jones, W. M., and Favata, E. J., and Fays, M., and Fee, M., and Fehrmann, C., and Feicht, H., and Fejer, J., and Fernandez-Galiana, M. 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N., and Lantz, J., and Lanza, B., and Larson, R. K., and Lartaux-Vollard, S. L., and Lasky, A., and Laxen, P. D., and Lazzarini, M., and Lazzaro, A., and Leaci, C., and Leavey, P., and Lee, S., and Lee, C. H., and Lee, H. K., and Lee, H. M., and Lee, H. W., and Lehmann, K., and Lenon, J., and Leonardi, A., and Leroy, M., and Letendre, N., and Levin, N., and Li, Y., and Linker, T. G. F., and Littenberg, S. D., and Liu, T. B., and Liu, J., and Lo, X., and Lockerbie, R. K. L., and London, N. A., and Lord, L. T., and Lorenzini, J. E., and Loriette, M., and Lormand, V., and Losurdo, M., and Lough, G., and Lousto, J. D., and Lovelace, C. O., and Lueck, G., and Lumaca, H., and Lundgren, D., and Lynch, A. P., and Ma, R., and Macas, Y., and Macfoy, R., and Machenschalk, S., and MacInnis, B., and Macleod, M., and Hernandez, D. M., Magana and Magana-Sandoval, I., and Zertuche, F., Magana and Magee, L., and Majorana, R. 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UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Fonctions Optiques pour les Technologies de l'informatiON ( FOTON ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National des Sciences Appliquées - Rennes ( INSA Rennes ) -École Nationale Supérieure des Sciences Appliquées et de Technologie ( ENSSAT ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Bretagne Loire ( UBL ) -IMT Atlantique Bretagne-Pays de la Loire ( IMT Atlantique ), Laboratoire Kastler Brossel ( LKB (Lhomond) ), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris ( FRDPENS ), Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Lyon, ESPCI ParisTech, LIGO Scientific, Virgo, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Kastler Brossel (LKB [Collège de France]), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Collège de France (CdF)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ITA, USA, GBR, FRA, DEU, ESP, Laboratoire d'Annecy de Physique des Particules (LAPP), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), Massachusetts Institute of Technology. Department of Aeronautics and Astronautics, Massachusetts Institute of Technology. Department of Mechanical Engineering, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, MIT Kavli Institute for Astrophysics and Space Research, Aggarwal, Neerja, Buikema, Aaron, Donovan, Frederick J, Eisenstein, Robert Alan, Essick, Reed Clasey, Fernandez Galiana, Alvaro-Miguel, Fritschel, Peter K, Gras, Slawomir, MacInnis, Myron E, Martynov, Denis, Mason, Kenneth R, Matichard, Fabrice, Mavalvala, Nergis, Miller, John, Vitale, Salvatore, Weiss, Rainer, Yu, Haocun, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), The LIGO Scientific Collaboration, The Virgo Collaboration, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Van Swinderen Institute for Particle Physics and G, Abbott, B. P., Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R. X., Adya, V. B., Affeldt, C., Afrough, M., Agarwal, B., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Allen, B., Allen, G., Allocca, A., Altin, P. A., Amato, A., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arnaud, N., Arun, K. G., Ascenzi, S., Ashton, G., Ast, M., Aston, S. M., Astone, P., Atallah, D. V., Aufmuth, P., Aulbert, C., Aultoneal, K., Austin, C., Avila-Alvarez, A., Babak, S., Bacon, P., Bader, M. K. M., Bae, S., Baker, P. T., Baldaccini, F., Ballardin, G., Banagiri, S., Barayoga, J. C., Barclay, S. E., Barish, B. C., Barker, D., Barkett, K., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Batch, J. C., Bawaj, M., Bayley, J. C., Bazzan, M., Bã©csy, B., Beer, C., Bejger, M., Belahcene, I., Bell, A. S., Bergmann, G., Bernuzzi, S., Bero, J. J., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhagwat, S., Bhandare, R., Bilenko, I. A., Billingsley, G., Billman, C. R., Birch, J., Birney, R., Birnholtz, O., Biscans, S., Biscoveanu, S., Bisht, A., Bitossi, M., Biwer, C., Bizouard, M. A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bloemen, S., Bock, O., Bode, N., Boer, M., Bogaert, G., Bohe, A., Bondu, F., Bonilla, E., Bonnand, R., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossie, K., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Branchesi, M., Brau, J. E., Briant, T., Brillet, A., Brinkmann, M., Brisson, V., Brockill, P., Broida, J. E., Brooks, A. F., Brown, D. D., Brunett, S., Buchanan, C. C., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Buy, C., Byer, R. L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. CalderÃ³n, Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Canizares, P., Cannon, K. C., Cao, H., Cao, J., Capano, C. D., Capocasa, E., Carbognani, F., Caride, S., Carney, M. F., Diaz, J. Casanueva, Casentini, C., Caudill, S., Cavagliã , M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C. B., CerdÃ¡-DurÃ¡n, P., Cerretani, G., Cesarini, E., Chamberlin, S. J., Chan, M., Chao, S., Charlton, P., Chase, E., Chassande-Mottin, E., Chatterjee, D., Chatziioannou, K., Cheeseboro, B. D., Chen, H. Y., Chen, X., Chen, Y., Cheng, H. -P., Chia, H., Chincarini, A., Chiummo, A., Chmiel, T., Cho, H. S., Cho, M., Chow, J. H., Christensen, N., Chu, Q., Chua, A. J. K., Chua, S., Chung, A. K. W., Chung, S., Ciani, G., Ciolfi, R., Cirelli, C. E., Cirone, A., Clara, F., Clark, J. A., Clearwater, P., Cleva, F., Cocchieri, C., Coccia, E., Cohadon, P. -F., Cohen, D., Colla, A., Collette, C. G., Cominsky, L. R., Constancio, M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-CarriÃ³n, I., Corley, K. R., Cornish, N., Corsi, A., Cortese, S., Costa, C. A., Coughlin, M. W., Coughlin, S. B., Coulon, J. -P., Countryman, S. T., Couvares, P., Covas, P. B., Cowan, E. E., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Cripe, J., Crowder, S. G., Cullen, T. J., Cumming, A., Cunningham, L., Cuoco, E., Dal Canton, T., Dã¡lya, G., Danilishin, S. L., D'Antonio, S., Danzmann, K., Dasgupta, A., Da Silva Costa, C. F., Dattilo, V., Dave, I., Davier, M., Davis, D., Daw, E. J., Day, B., De, S., Debra, D., Degallaix, J., De Laurentis, M., Delã©glise, S., Del Pozzo, W., Demos, N., Denker, T., Dent, T., De Pietri, R., Dergachev, V., De Rosa, Rosario., Derosa, R. T., De Rossi, C., Desalvo, R., De Varona, O., Devenson, J., Dhurandhar, S., Dãaz, M. C., Dietrich, T., Di Fiore, L., Di Giovanni, M., Di Girolamo, Tristano., Di Lieto, A., Di Pace, S., Di Palma, I., Di Renzo, F., Doctor, Z., Dolique, V., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Douglas, R., Ã lvarez, M. Dovale, Downes, T. P., Drago, M., Dreissigacker, C., Driggers, J. C., Du, Z., Ducrot, M., Dupej, P., Dwyer, S. E., Edo, T. B., Edwards, M. C., Effler, A., Eggenstein, H. -B., Ehrens, P., Eichholz, J., Eikenberry, S. S., Eisenstein, R. A., Essick, R. C., Estevez, D., Etienne, Z. B., Etzel, T., Evans, M., Evans, T. M., Factourovich, M., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farinon, S., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favata, M., Fays, M., Fee, C., Fehrmann, H., Feicht, J., Fejer, M. M., Fernandez-Galiana, A., Ferrante, I., Ferreira, E. C., Ferrini, F., Fidecaro, F., Finstad, D., Fiori, I., Fiorucci, D., Fishbach, M., Fisher, R. P., Fitz-Axen, M., Flaminio, R., Fletcher, M., Fong, H., Font, J. A., Forsyth, P. W. F., Forsyth, S. S., Fournier, J. -D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fries, E. M., Fritschel, P., Frolov, V. V., Fulda, P., Fyffe, M., Gabbard, H., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gammaitoni, L., Ganija, M. R., Gaonkar, S. G., Garcia-Quiros, C., Garufi, F., Gateley, B., Gaudio, S., Gaur, G., Gayathri, V., Gehrels, N., Gemme, G., Genin, E., Gennai, A., George, D., George, J., Gergely, L., Germain, V., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giaime, J. A., Giardina, K. D., Giazotto, A., Gill, K., Glover, L., Goetz, E., Goetz, R., Gomes, S., Goncharov, B., Gonzã¡lez, G., Castro, J. M. Gonzalez, Gopakumar, A., Gorodetsky, M. L., Gossan, S. E., Gosselin, M., Gouaty, R., Grado, A., Graef, C., Granata, M., Grant, A., Gras, S., Gray, C., Greco, G., Green, A. C., Gretarsson, E. M., Groot, P., Grote, H., Grunewald, S., Gruning, P., Guidi, G. M., Guo, X., Gupta, A., Gupta, M. K., Gushwa, K. E., Gustafson, E. K., Gustafson, R., Halim, O., Hall, B. R., Hall, E. D., Hamilton, E. Z., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hanson, J., Hardwick, T., Harms, J., Harry, G. M., Harry, I. W., Hart, M. J., Haster, C. -J., Haughian, K., Healy, J., Heidmann, A., Heintze, M. C., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Hennig, J., Heptonstall, A. W., Heurs, M., Hild, S., Hinderer, T., Hoak, D., Hofman, D., Holt, K., Holz, D. E., Hopkins, P., Horst, C., Hough, J., Houston, E. A., Howell, E. J., Hreibi, A., Hu, Y. M., Huerta, E. A., Huet, D., Hughey, B., Husa, S., Huttner, S. H., Huynh-Dinh, T., Indik, N., Inta, R., Intini, G., Isa, H. N., Isac, J. -M., Isi, M., Iyer, B. R., Izumi, K., Jacqmin, T., Jani, K., Jaranowski, P., Jawahar, S., JimÃ©nez-Forteza, F., Johnson, W. W., Johnson-Mcdaniel, N. K., Jones, D. I., Jones, R., Jonker, R. J. G., Ju, L., Junker, J., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Karki, S., Karvinen, K. S., Kasprzack, M., Kastaun, W., Katolik, M., Katsavounidis, E., Katzman, W., Kaufer, S., Kawabe, K., Kawaguchi, K., Kã©fã©lian, F., Keitel, D., Kemball, A. J., Kennedy, R., Kent, C., Key, J. S., Khalili, F. Y., Khan, I., Khan, S., Khan, Z., Khazanov, E. A., Kijbunchoo, N., Kim, Chunglee, Kim, J. C., Kim, K., Kim, W., Kim, W. S., Kim, Y. -M., Kimbrell, S. J., King, E. J., King, P. J., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kleybolte, L., Klimenko, S., Knowles, T. D., Koch, P., Koehlenbeck, S. M., Koley, S., Kondrashov, V., Kontos, A., Korobko, M., Korth, W. Z., Kowalska, I., Kozak, D. B., Krã¤mer, C., Kringel, V., Krã³lak, A., Kuehn, G., Kumar, P., Kumar, R., Kumar, S., Kuo, L., Kutynia, A., Kwang, S., Lackey, B. D., Lai, K. H., Landry, M., Lang, R. N., Lange, J., Lantz, B., Lanza, R. K., Larson, S. L., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lee, C. H., Lee, H. K., Lee, H. M., Lee, H. W., Lee, K., Lehmann, J., Lenon, A., Leonardi, M., Leroy, N., Letendre, N., Levin, Y., Li, T. G. F., Linker, S. D., Littenberg, T. B., Liu, J., Liu, X., Lo, R. K. L., Lockerbie, N. A., London, L. T., Lord, J. E., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lousto, C. O., Lovelace, G., Lã¼ck, H., Lumaca, D., Lundgren, A. P., Lynch, R., Ma, Y., Macas, R., Macfoy, S., Machenschalk, B., Macinnis, M., Macleod, D. M., Hernandez, I. MagaÃ±a, MagaÃ±a-Sandoval, F., Zertuche, L. MagaÃ±a, Magee, R. M., Majorana, E., Maksimovic, I., Man, N., Mandic, V., Mangano, V., Mansell, G. L., Manske, M., Mantovani, M., Marchesoni, F., Marion, F., Mã¡rka, S., Mã¡rka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Martelli, F., Martellini, L., Martin, I. W., Martin, R. M., Martynov, D. V., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Matichard, F., Matone, L., Mavalvala, N., Mazumder, N., Mccarthy, R., Mcclelland, D. E., Mccormick, S., Mcculler, L., Mcguire, S. C., Mcintyre, G., Mciver, J., Mcmanus, D. J., Mcneill, L., Mcrae, T., Mcwilliams, S. T., Meacher, D., Meadors, G. D., Mehmet, M., Meidam, J., Mejuto-Villa, E., Melatos, A., Mendell, G., Mercer, R. A., Merilh, E. L., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Miao, H., Michel, C., Middleton, H., Mikhailov, E. E., Milano, L., Miller, A. L., Miller, B. B., Miller, J., Millhouse, M., Milovich-Goff, M. C., Minazzoli, O., Minenkov, Y., Ming, J., Mishra, C., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Moffa, D., Moggi, A., Mogushi, K., Mohan, M., Mohapatra, S. R. P., Montani, M., Moore, C. J., Moraru, D., Moreno, G., Morriss, S. R., Mours, B., Mow-Lowry, C. M., Mueller, G., Muir, A. W., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukund, N., Mullavey, A., Munch, J., Muã±iz, E. A., Muratore, M., Murray, P. G., Napier, K., Nardecchia, I., Naticchioni, L., Nayak, R. K., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neunzert, A., Nevin, L., Newport, J. M., Newton, G., Ng, K. K. Y., Nguyen, T. T., Nichols, D., Nielsen, A. B., Nissanke, S., Nitz, A., Noack, A., Nocera, F., Nolting, D., North, C., Nuttall, L. K., Oberling, J., O'Dea, G. D., Ogin, G. H., Oh, J. J., Oh, S. H., Ohme, F., Okada, M. A., Oliver, M., Oppermann, P., Oram, Richard J., O'Reilly, B., Ormiston, R., Ortega, L. F., O'Shaughnessy, R., Ossokine, S., Ottaway, D. J., Overmier, H., Owen, B. J., Pace, A. E., Page, J., Page, M. A., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pal-Singh, A., Pan, Howard, Pan, Huang-Wei, Pang, B., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Papa, M. A., Parida, A., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patil, M., Patricelli, B., Pearlstone, B. L., Pedraza, M., Pedurand, R., Pekowsky, L., Pele, A., Penn, S., Perez, C. J., Perreca, A., Perri, L. M., Pfeiffer, H. P., Phelps, M., Piccinni, O. J., Pichot, M., Piergiovanni, F., Pierro, V., Pillant, G., Pinard, L., Pinto, I. M., Pirello, M., Pitkin, M., Poe, M., Poggiani, R., Popolizio, P., Porter, E. K., Post, A., Powell, J., Prasad, J., Pratt, J. W. W., Pratten, G., Predoi, V., Prestegard, T., Prijatelj, M., Principe, M., Privitera, S., Prodi, G. A., Prokhorov, L. G., Puncken, O., Punturo, M., Puppo, P., Pã¼rrer, M., Qi, H., Quetschke, V., Quintero, E. A., Quitzow-James, R., Rabeling, D. S., Radkins, H., Raffai, P., Raja, S., Rajan, C., Rajbhandari, B., Rakhmanov, M., Ramirez, K. E., Ramos-Buades, A., Rapagnani, P., Raymond, V., Razzano, M., Read, J., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Ren, W., Reyes, S. D., Ricci, F., Ricker, P. M., Rieger, S., Riles, K., Rizzo, M., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rolland, L., Rollins, J. G., Roma, V. J., Romano, R., Romel, C. L., Romie, J. H., RosiÅ„ska, D., Ross, M. 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E., Zweizig, J., (Astro)-Particles Physics, École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)
Subjects: binary: mass, neutron star: binary, long-lived, Astronomy, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Astrophysics, Kilonova, rotation, 01 natural sciences, GW170817, mass spectrum, ultraviolet, ELEMENTS, black hole, optical, Astrophysics::Solar and Stellar Astrophysics, LIGO, Ejecta, gravitational wave, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 010303 astronomy & astrophysics, QC, QB, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), SUPERNOVAE, EQUATION-OF-STATE, LIGHT, gravitational waves, mass: ejection, infrared, Physique des particules élémentaires, Astrophysics - High Energy Astrophysical Phenomena, methods: data analysi, signature, MASS EJECTION, Milky Way, Astrophysics::High Energy Astrophysical Phenomena, brightness, FOS: Physical sciences, NEUTRON-STAR MERGERS, Astrophysics::Cosmology and Extragalactic Astrophysics, Type (model theory), angular momentum, Bayesian, methods: data analysis, stars: neutron, Astronomy and Astrophysics, Space and Planetary Science, neutron [stars], 0103 physical sciences, GW170817, Kilonova, Ejecta, LIGO, Virgo, data analysis [methods], numerical calculations, equation of state, Astrophysics::Galaxy Astrophysics, COUNTERPART, 010308 nuclear & particles physics, Virgo, gravitational radiation, Astronomy and Astrophysic, R-PROCESS NUCLEOSYNTHESIS, calibration, redshift, Light curve, Galaxy, Abundance of the chemical elements, Neutron star, VIRGO, electromagnetic, Physics and Astronomy, EVENT, galaxy, data analysis, stars: neutron [gravitational waves, methods], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], MATTER
Abstract: The source of the gravitational-wave (GW) signal GW170817, very likely a binary neutron star merger, was also observed electromagnetically, providing the first multi-messenger observations of this type. The two-week-long electromagnetic (EM) counterpart had a signature indicative of an r-process-induced optical transient known as a kilonova. This Letter examines how the mass of the dynamical ejecta can be estimated without a direct electromagnetic observation of the kilonova, using GW measurements and a phenomenological model calibrated to numerical simulations of mergers with dynamical ejecta. Specifically, we apply the model to the binary masses inferred from the GW measurements, and use the resulting mass of the dynamical ejecta to estimate its contribution (without the effects of wind ejecta) to the corresponding kilonova light curves from various models. The distributions of dynamical ejecta mass range between M ej = 10 -3 - 10 -2 M ⊙ for various equations of state, assuming that the neutron stars are rotating slowly. In addition, we use our estimates of the dynamical ejecta mass and the neutron star merger rates inferred from GW170817 to constrain the contribution of events like this to the r-process element abundance in the Galaxy when ejecta mass from post-merger winds is neglected. We find that if ≳10% of the matter dynamically ejected from binary neutron star (BNS) mergers is converted to r-process elements, GW170817-like BNS mergers could fully account for the amount of r-process material observed in the Milky Way., National Science Foundation (U.S.), Science and Technology Facilities Council (Great Britain), Max Planck Society
Published: 2017
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11. A gravitational-wave standard siren measurement of the Hubble constant

Author: Abbott, and Abbott, B. P., and Abbott, R., and Acernese, T. D., and Ackley, F., and Adams, K., and Adams, C., and Addesso, T., and Adhikari, P., and Adya, R. X., and Affeldt, V. B., and Afrough, C., and Agarwal, M., and Agathos, B., and Agatsuma, M., and Aggarwal, K., and Aguiar, N., and Aiello, O. D., and Ain, L., and Ajith, A., and Allen, P., and Allen, B., and Allocca, G., and Altin, A., and Amato, P. A., and Ananyeva, A., and Anderson, A., and Anderson, S. B., and Angelova, W. G., and Antier, S. V., and Appert, S., and Arai, S., and Araya, K., and Areeda, M. C., and Arnaud, J. S., and Arun, N., and Ascenzi, K. G., and Ashton, S., and Ast, G., and Aston, M., and Astone, S. M., and Atallah, P., and Aufmuth, D. V., and Aulbert, P., and AultO'Neal, C., and Austin, K., and Avila-Alvarez, C., and Babak, A., and Bacon, S., and Bader, P., and Bae, M. K. M., and Baker, S., and Baldaccini, P. T., and Ballardin, F., and Ballmer, G., and Banagiri, S. W., and Barayoga, S., and Barclay, J. C., and Barish, S. E., and Barker, B. C., and Barkett, D., and Barone, K., and Barr, F., and Barsotti, B., and Barsuglia, L., and Barta, M., and Bartlett, D., and Bartos, J., and Bassiri, I., and Basti, R., and Batch, N., and Bawaj, J. C., and Bayley, M., and Bazzan, J. C., and Becsy, M., and Beer, B., and Bejger, C., and Belahcene, M., and Bell, I., and Berger, A. S., and Bergmann, B. K., and Bero, G., and Berry, J. J., and Bersanetti, C. P. L., and Bertolini, D., and Betzwieser, A., and Bhagwat, J., and Bhandare, S., and Bilenko, R., and Billingsley, I. A., and Billman, G., and Birch, C. R., and Birney, J., and Birnholtz, R., and Biscans, O., and Biscoveanu, S., and Bisht, S., and Bitossi, A., and Biwer, M., and Bizouard, C., and Blackburn, A., and Blackman, J. K., and Blair, J., and Blair, C. D., and Blair, D. G., and Bloemen, R. 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B., Bechtol, K., Benoit-Lévy, A., Bertin, E., Bridle, S. L., Brooks, D., Buckley-Geer, E., Burke, D. L., Carnero Rosell, A., Carrasco Kind, M., Carretero, J., Castander, F. J., Cunha, C. E., D'Andrea, C. B., Da Costa, L. N., Davis, C., Depoy, D. L., Desai, S., Dietrich, J. P., Estrada, J., Fernandez, E., Flaugher, B., Fosalba, P., Gaztanaga, E., Gerdes, D. W., Giannantonio, T., Goldstein, D. A., Gruen, D., Gutierrez, G., Hartley, W. G., Honscheid, K., Jain, B., James, D. J., Jeltema, T., Johnson, M. W. G., Kent, S., Krause, E., Kron, R., Kuehn, K., Kuhlmann, S., Kuropatkin, N., Lahav, O., Lima, M., Maia, M. A. G., March, M., Miller, C. J., Miquel, R., Neilsen, E., Nord, B., Ogando, R. L. C., Plazas, A. A., Romer, A. K., Roodman, A., Rykoff, E. S., Sanchez, E., Scarpine, V., Schubnell, M., Sevilla-Noarbe, I., Smith, M., Smith, R. C., Suchyta, E., Tarle, G., Thomas, D., Thomas, R. C., Troxel, M. A., Tucker, D. L., Vikram, V., Walker, A. R., Weller, J., Zhang, Y., Haislip, J. B., Kouprianov, V. V., Reichart, D. E., Tartaglia, L., Sand, D. J., Valenti, S., Yang, S., Arcavi, Iair, Hosseinzadeh, Griffin, Howell, D. Andrew, Mccully, Curti, Poznanski, Dovi, Vasylyev, Sergiy, Tanvir, N. R., Levan, A. J., Hjorth, J., Cano, Z., Copperwheat, C., De Ugarte-Postigo, A., Evans, P. A., Fynbo, J. P. U., González-Fernández, C., Greiner, J., Irwin, M., Lyman, J., Mandel, I., Mcmahon, R., Milvang-Jensen, B., O'Brien, P., Osborne, J. P., Perley, D. A., Pian, E., Palazzi, E., Rol, E., Rosetti, S., Rosswog, S., Rowlinson, A., Schulze, S., Steeghs, D. T. H., Thöne, C. C., Ulaczyk, K., Watson, D., Wiersema, K., Lipunov, V. M., Gorbovskoy, E., Kornilov, V. G., Tyurina, N., Balanutsa, P., Vlasenko, D., Gorbunov, I., Podesta, R., Levato, H., Saffe, C., Buckley, D. A. H., Budnev, N. M., Gress, O., Yurkov, V., Rebolo, R., Serra-Ricart, M., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des matériaux avancés ( LMA ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Fonctions Optiques pour les Technologies de l'informatiON ( FOTON ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National des Sciences Appliquées - Rennes ( INSA Rennes ) -École Nationale Supérieure des Sciences Appliquées et de Technologie ( ENSSAT ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Bretagne Loire ( UBL ) -IMT Atlantique Bretagne-Pays de la Loire ( IMT Atlantique ), Laboratoire Kastler Brossel ( LKB (Lhomond) ), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris ( FRDPENS ), Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Institut d'Astrophysique de Paris ( IAP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), ITA, USA, GBR, FRA, DEU, ESP, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), The LIGO Scientific Collaboration, The Virgo Collaboration, The 1M2H Collaboration, The Dark Energy Camera GW-EM Collaboration, The DES Collaboration, The DLT40 Collaboration, The Las Cumbres Observatory Collaboration, The VINROUGE Collaboration, The MASTER Collaboration, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and (Astro)-Particles Physics
Subjects: Gamma-Ray Bursts, cosmological model, neutron star: binary, Cosmology and Nongalactic Astrophysics (astro-ph.CO), [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Astrophysics::High Energy Astrophysical Phenomena, Density, Field, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: burst, gravitational radiation: direct detection, General Relativity and Quantum Cosmology, LIGO, QC, Astrophysics::Galaxy Astrophysics, QB, Gravitational Waves, Gravitational Waves, Hubble Constant, LIGO, Virgo, Multidisciplinary, Hubble constant, Virgo, Hubble Constant, Astrophysics::Instrumentation and Methods for Astrophysics, Galaxies, wave: electromagnetic, Telescope Key Project, VIRGO, gravitational radiation: emission, astro-ph.CO, galaxy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The detection of GW170817 in both gravitational waves and electromagnetic waves heralds the age of gravitational-wave multi-messenger astronomy. On 17 August 2017 the Advanced LIGO and Virgo detectors observed GW170817, a strong signal from the merger of a binary neutron-star system. Less than 2 seconds after the merger, a gamma-ray burst (GRB 170817A) was detected within a region of the sky consistent with the LIGO-Virgo-derived location of the gravitational-wave source. This sky region was subsequently observed by optical astronomy facilities, resulting in the identification of an optical transient signal within $\sim 10$ arcsec of the galaxy NGC 4993. These multi-messenger observations allow us to use GW170817 as a standard siren, the gravitational-wave analog of an astronomical standard candle, to measure the Hubble constant. This quantity, which represents the local expansion rate of the Universe, sets the overall scale of the Universe and is of fundamental importance to cosmology. Our measurement combines the distance to the source inferred purely from the gravitational-wave signal with the recession velocity inferred from measurements of the redshift using electromagnetic data. This approach does not require any form of cosmic "distance ladder;" the gravitational wave analysis can be used to estimate the luminosity distance out to cosmological scales directly, without the use of intermediate astronomical distance measurements. We determine the Hubble constant to be $70.0^{+12.0}_{-8.0} \, \mathrm{km} \, \mathrm{s}^{-1} \, \mathrm{Mpc}^{-1}$ (maximum a posteriori and 68% credible interval). This is consistent with existing measurements, while being completely independent of them. Additional standard-siren measurements from future gravitational-wave sources will provide precision constraints of this important cosmological parameter., Comment: 26 pages, 5 figures, Nature in press. For more information see https://dcc.ligo.org/LIGO-P1700296/public
Published: 2017
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12. Improved analysis of GW150914 using a fully spin-precessing waveform model

Author: Abbott, B. P., Abbott, Abbott, R., Abernathy, T. D., Acernese, M. R., Ackley, F., Adams, K., Adams, C., Addesso, T., Adhikari, P., Adya, R. X., Affeldt, V. B., Agathos, C., Agatsuma, M., Aggarwal, K., Aguiar, N., Aiello, O. D., Ain, L., Ajith, A., Allen, P., Allocca, B., Altin, A., Anderson, P. A., Anderson, S. B., Arai, W. G., Araya, K., Arceneaux, M. C., Areeda, C. C., Arnaud, J. S., Arun, N., Ascenzi, K. G., Ashton, S., Ast, G., Aston, M., Astone, S. M., Aufmuth, P., Aulbert, P., Babak, C., Bacon, S., Bader, P., Baker, M. K. M., Baldaccini, P. T., Ballardin, F., Ballmer, G., Barayoga, S. W., Barclay, J. C., Barish, S. E., Barker, B. C., Barone, D., Barr, F., Barsotti, B., Barsuglia, L., Barta, M., Bartlett, D., Bartos, J., Bassiri, I., Basti, R., Batch, A., Baune, J. C., Bavigadda, C., Bazzan, V., Bejger, M., Bell, M., Berger, A. S., Bergmann, B. K., Berry, G., Bersanetti, C. P. L., Bertolini, D., Betzwieser, A., Bhagwat, J., Bhandare, S., Bilenko, R., Billingsley, I. A., Birch, G., Birney, J., Birnholtz, R., Biscans, O., Bisht, S., Bitossi, A., Biwer, M., Bizouard, C., Blackburn, M. A., Blair, J. K., Blair, C. D., Blair, D. G., Bloemen, R. M., Bock, S., Boer, O., Bogaert, M., Bogan, G., Bohe, C., Bond, A., Bondu, C., Bonnand, F., Boom, R., Bork, B. A., Boschi, R., Bose, V., Bouffanais, S., Bozzi, Y., Bradaschia, A., Brady, C., Braginsky, P. R., Branchesi, V. B., Brau, M., Briant, J. E., Brillet, T., Brinkmann, A., Brisson, M., Brockill, V., Broida, P., Brooks, J. E., Brown, A. F., Brown, D. A., Brown, D. D., Brunett, N. M., Buchanan, S., Buikema, C. C., Bulik, A., Bulten, T., Buonanno, H. J., Buskulic, A., Buy, D., Byer, C., Cabero, R. L., Cadonati, M., Cagnoli, L., Cahillane, G., Calderón Bustillo, C., Callister, J., Calloni, T., Camp, E., Cannon, J. B., Cao, K. C., Capano, J., Capocasa, C. D., Carbognani, E., Caride, F., Casanueva Diaz, S., Casentini, C., Caudill, J., Cavaglià, S., Cavalier, M., Cavalieri, F., Cella, R., Cepeda, G., Cerboni Baiardi, C. B., Cerretani, L., Cesarini, G., Chamberlin, E., Chan, S. J., Chao, M., Charlton, S., Chassande Mottin, P., Cheeseboro, E., Chen, B. D., Chen, H. Y., Cheng, Y., Chincarini, C., Chiummo, A., Cho, A., Cho, H. S., Chow, M., Christensen, J. H., Chu, N., Chua, Q., Chung, S., Ciani, S., Clara, G., Clark, F., Cleva, J. A., Coccia, F., Cohadon, E., Colla, P. F., Collette, A., Cominsky, C. G., Constancio, L., Conte, M., Conti, A., Cook, L., Corbitt, D., Cornish, T. R., Corsi, N., Cortese, A., Costa, S., Coughlin, C. A., Coughlin, M. W., Coulon, S. B., Countryman, J. P., Couvares, S. T., Cowan, P., Coward, E. E., Cowart, D. M., Coyne, M. J., Coyne, D. C., Craig, R., Creighton, K., Cripe, J. D. E., Crowder, J., Cumming, S. G., Cunningham, A., Cuoco, L., Dal Canton, E., Danilishin, T., D'Antonio, S. L., Danzmann, S., Darman, K., Dasgupta, N. S., Da Silva Costa, A., Dattilo, C. F., Dave, V., Davier, I., Davies, M., Daw, G. S., Day, E. J., De, R., Debra, S., Debreczeni, D., Degallaix, G., De Laurentis, J., Deléglise, M., Del Pozzo, S., Denker, W., Dent, T., Dergachev, T., De Rosa, V., Derosa, R., Desalvo, R. T., Devine, R., Dhurandhar, R. C., Díaz, S., Di Fiore, M. C., Di Giovanni, L., Di Girolamo, M., Di Lieto, T., Di Pace, A., Di Palma, S., Di Virgilio, I., Dolique, A., Donovan, V., Dooley, F., Doravari, K. L., Douglas, S., Downes, R., Drago, T. P., Drever, M., Driggers, R. W. P., Ducrot, J. C., Dwyer, M., Edo, S. E., Edwards, T. B., Effler, M. C., Eggenstein, A., Ehrens, H. B., Eichholz, P., Eikenberry, J., Engels, S. S., Essick, W., Etienne, R. C., Etzel, Z., Evans, T., Evans, M., Everett, T. M., Factourovich, R., Fafone, M., Fair, V., Fairhurst, H., Fan, S., Fang, X., Farinon, Q., Farr, S., Farr, B., Fauchon Jones, W. M., Favata, E., Fays, M., Fehrmann, M., Fejer, H., Fenyvesi, M. M., Ferrante, E., Ferreira, I., Ferrini, E. C., Fidecaro, F., Fiori, F., Fiorucci, I., Fisher, D., Flaminio, R. P., Fletcher, R., Fournier, M., Frasca, J. D., Frasconi, S., Frei, F., Freise, Z., Frey, A., Frey, R., Fritschel, V., Frolov, P., Fulda, V. V., Fyffe, P., Gabbard, M., Gaebel, H. A. G., Gair, S., And, J. R., Gammaitoni, Luca, Gaonkar, And, Garufi, S. G., Gaur, F., Gehrels, G., Gemme, N., Geng, G., Genin, P., Gennai, E., George, A., Gergely, J., Germain, L., Ghosh, V., Ghosh, A., Giaime, S., Giardina, J. A., Giazotto, K. D., Gill, A., Glaefke, K., Goetz, A., Goetz, E., Gondan, R., González, L., Gonzalez Castro, G., Gopakumar, J. M., Gordon, A., Gorodetsky, N. A., Gossan, M. L., Gosselin, S. E., Gouaty, M., Grado, R., Graef, A., Graff, C., Granata, P. B., Grant, M., Gras, A., Gray, S., Greco, C., Green, G., Groot, A. C., Grote, P., Grunewald, H., Guidi, S., Guo, G. M., Gupta, X., Gupta, A., Gushwa, M. 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H., Oliver, F., Oppermann, M., Oram, P., O'Reilly, R. J., O'Shaughnessy, B., Ottaway, R., Overmier, D. J., Owen, H., Pai, B. J., Pai, A., Palamos, S. A., Palashov, J. R., Palomba, O., Pal Singh, C., Pan, A., Pankow, H., Pannarale, C., Pant, F., Paoletti, B. C., Paoli, F., Papa, A., Paris, M. A., Parker, H. R., Pascucci, W., Pasqualetti, D., Passaquieti, A., Passuello, R., Patricelli, D., Patrick, B., Pearlstone, Z., Pedraza, B. L., Pedurand, M., Pekowsky, R., Pele, L., Penn, A., Perreca, S., Perri, A., Pfeiffer, L. M., Phelps, H. P., Piccinni, M., Pichot, O. J., Piergiovanni, M., Pierro, F., Pillant, V., Pinard, G., Pinto, L., Pitkin, I. M., Poe, M., Poggiani, M., Popolizio, R., Post, P., Powell, A., Prasad, J., Predoi, J., Prestegard, V., Price, T., Prijatelj, L. R., Principe, M., Privitera, M., Prix, S., Prodi, R., Prokhorov, G. A., Puncken, L., And, O., Punturo, Michele, Puppo, And, Pürrer, P., Qi, M., Qin, H., Qiu, J., Quetschke, S., Quintero, V., Quitzow James, E. A., Raab, R., Rabeling, F. J., Radkins, D. S., Raffai, H., Raja, P., Rajan, S., Rakhmanov, C., Rapagnani, M., Raymond, P., Razzano, V., Re, M., Read, V., Reed, J., Regimbau, C. M., Rei, T., Reid, L., Reitze, S., Rew, D. H., Reyes, H., Ricci, S. D., Riles, F., Rizzo, K., Robertson, M., Robie, N. A., Robinet, R., Rocchi, F., Rolland, A., Rollins, L., Roma, J. G., Romano, V. J., Romanov, R., Romie, G., Rosinska, J. H., Rowan, D., Rüdiger, S., Ruggi, A., Ryan, P., Sachdev, K., Sadecki, S., Sadeghian, T., Sakellariadou, L., Salconi, M., Saleem, L., Salemi, M., Samajdar, F., Sammut, A., Sanchez, L., Sandberg, E. J., Sandeen, V., Sanders, B., Sassolas, J. R., Sathyaprakash, B., Saulson, B. S., Sauter, P. R., Savage, O. E. S., Sawadsky, R. L., Schale, A., Schilling, P., Schmidt, R., Schmidt, J., Schnabel, P., Schofield, R., Schönbeck, R. M. S., Schreiber, A., Schuette, E., Schutz, D., Scott, B. F., Scott, J., Sellers, S. M., Sengupta, D., Sentenac, A. 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S., Tiwari, E., Tiwari, S., Tokmakov, V., Toland, K. V., Tomlinson, K., Tonelli, C., Tornasi, M., Torres, Z., Torrie, C. V., Töyrä, C. I., And, D., Travasso, Flavio, Traylor, And, Trifirò, G., Tringali, D., Trozzo, M. C., Tse, L., Turconi, M., Tuyenbayev, M., Ugolini, D., Unnikrishnan, D., Urban, C. S., Usman, A. L., Vahlbruch, S. A., Vajente, H., Valdes, G., Vallisneri, G., van Bakel, M., van Beuzekom, N., van den Brand, M., Van Den Broeck, J. F. J., Vander Hyde, C., van der Schaaf, D. C., van der Sluys, L., van Heijningen, M. V., Vano Vinuales, J. V., van Veggel, A., Vardaro, A. A., Vass, M., Vasúth, S., Vaulin, M., Vecchio, R., Vedovato, A., Veitch, G., Veitch, J., Venkateswara, P. J., Verkindt, K., Vetrano, D., Viceré, F., Vinciguerra, A., Vine, S., Vinet, D. J., Vitale, J. Y., Vo, S., And, T., Vocca, Helios, Vorvick, And, Voss, C., Vousden, D. V., Vyatchanin, W. D., Wade, S. P., Wade, A. R., Wade, L. E., Walker, M., Wallace, M., Walsh, L., Wang, S., Wang, G., Wang, H., Wang, M., Wang, X., Ward, Y., Warner, R. L., Was, J., Weaver, M., Wei, B., Weinert, L. W., Weinstein, M., Weiss, A. J., Wen, R., Weßels, L., Westphal, P., Wette, T., Whelan, K., Whiting, J. T., Williams, B. F., Williamson, R. D., Willis, A. R., Willke, J. L., Wimmer, B., Winkler, M. H., Wipf, W., Wittel, C. C., Woan, H., Woehler, G., Worden, J., Wright, J., J. L., Wu, D. S., Wu, Yablon, G., Yam, J., Yamamoto, W., Yancey, H., C. C., Yu, Yvert, H., Zadrozny, M., Zangrando, A., Zanolin, L., Zendri, M., Zevin, J. P., Zhang, M., Zhang, L., Zhao, Y., Zhou, C., Zhou, M., Zhu, Z., Zucker, X. J., Zuraw, M. E., Zweizig, S. E., Boyle, J., Brügmann, M., Campanelli, B., Chu, M., Clark, T., Haas, M., Hemberger, R., Hinder, D., Kidder, I., Kinsey, L. 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Anderson, S. .b., Anderson, W. .g., Arai, K., Araya, M. .c., Arceneaux, C. .c., Areeda, J. .s., Arnaud, N., Arun, K. .g., Ascenzi, S., Ashton, G., Ast, M., Aston, S. .m., Astone, P., Aufmuth, P., Aulbert, C., Babak, S., Bacon, P., Bader, M. .k. .m., Baker, P. .t., Baldaccini, F., Ballardin, G., Ballmer, S. .w., Barayoga, J. .c., Barclay, S. .e., Barish, B. .c., Barker, D., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Batch, J. .c., Baune, C., Bavigadda, V., Bazzan, M., Bejger, M., Bell, A. .s., Berger, B. .k., Bergmann, G., Berry, C. .p. .l., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhagwat, S., Bhandare, R., Bilenko, I. .a., Billingsley, G., Birch, J., Birney, R., Birnholtz, O., Biscans, S., Bisht, A., Bitossi, M., Biwer, C., Bizouard, M. .a., Blackburn, J. .k., Blair, C. .d., Blair, D. .g., Blair, R. .m., Bloemen, S., Bock, O., Boer, M., Bogaert, G., Bogan, C., Bohe, A., Bond, C., Bondu, F., Bonnand, R., Boom, 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J., Haughian, K., Healy, J., Heidmann, A., Heintze, M. .c., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I. .s., Hennig, J., Henry, J., Heptonstall, A. .w., Heurs, M., Hild, S., Hoak, D., Hofman, D., Holt, K., Holz, D. .e., Hopkins, P., Hough, J., Houston, E. .a., Howell, E. .j., Hu, Y. .m., Huang, S., Huerta, E. .a., Huet, D., Hughey, B., Husa, S., Huttner, S. .h., Huynh Dinh, T., Indik, N., Ingram, D. .r., Inta, R., Isa, H. .n., Isac, J. M., Isi, M., Isogai, T., Iyer, B. .r., Izumi, K., Jacqmin, T., Jang, H., Jani, K., Jaranowski, P., Jawahar, S., Jian, L., Jiménez Forteza, F., Johnson, W. .w., Johnson McDaniel, N. .k., Jones, D. .i., Jones, R., Jonker, R. .j. .g., Ju, L., K, Hari, Kalaghatgi, C. .v., Kalogera, V., Kandhasamy, S., Kang, G., Kanner, J. .b., Kapadia, S. .j., Karki, S., Karvinen, K. .s., Kasprzack, M., Katsavounidis, E., Katzman, W., Kaufer, S., Kaur, T., Kawabe, K., Kéfélian, F., Kehl, M. .s., Keitel, D., Kelley, D. .b., Kells, W., Kennedy, R., Key, J. .s., Khalili, F. .y., Khan, I., Khan, S., Khan, Z., Khazanov, E. .a., Kijbunchoo, N., Kim, Chi Woong, Kim, Chunglee, Kim, J., Kim, K., Kim, N., Kim, W., Kim, Y. M., Kimbrell, S. .j., King, E. .j., King, P. .j., Kissel, J. .s., Klein, B., Kleybolte, L., Klimenko, S., Koehlenbeck, S. .m., Koley, S., Kondrashov, V., Kontos, A., Korobko, M., Korth, W. .z., Kowalska, I., Kozak, D. .b., Kringel, V., Królak, A., Krueger, C., Kuehn, G., Kumar, P., Kumar, R., Kuo, L., Kutynia, A., Lackey, B. .d., Landry, M., Lange, J., Lantz, B., Lasky, P. .d., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lebigot, E. .o., Lee, C. .h., Lee, H. .k., Lee, H. .m., Lee, K., Lenon, A., Leonardi, M., Leong, J. .r., Leroy, N., Letendre, N., Levin, Y., Lewis, J. .b., Li, T. .g. .f., Libson, A., Littenberg, T. .b., Lockerbie, N. .a., Lombardi, A. .l., London, L. .t., Lord, J. .e., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. .d., Lousto, C. .o., Lovelace, G., Lück, H., Lundgren, A. .p., Lynch, R., Ma, Y., Machenschalk, B., Macinnis, M., Macleod, D. .m., Magaña Sandoval, F., Magaña Zertuche, L., Magee, R. .m., Majorana, E., Maksimovic, I., Malvezzi, V., Man, N., Mandic, V., Mangano, V., Mansell, G. .l., Manske, M., Mantovani, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markosyan, A. .s., Maros, E., MARTELLI, FILIPPO, Martellini, L., Martin, I. .w., Martynov, D. .v., Marx, J. .n., Mason, K., Masserot, A., Massinger, T. .j., Masso Reid, M., Mastrogiovanni, S., Matichard, F., Matone, L., Mavalvala, N., Mazumder, N., Mccarthy, R., Mcclelland, D. .e., Mccormick, S., Mcguire, S. .c., Mcintyre, G., Mciver, J., Mcmanus, D. .j., Mcrae, T., Mcwilliams, S. .t., Meacher, D., Meadors, G. .d., Meidam, J., Melatos, A., Mendell, G., Mercer, R. .a., Merilh, E. .l., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. .m., Mezzani, F., Miao, H., Michel, C., Middleton, H., Mikhailov, E. .e., Milano, L., Miller, A. .l., Miller, A., Miller, B. .b., Miller, J., Millhouse, M., Minenkov, Y., Ming, J., Mirshekari, S., Mishra, C., Mitra, S., Mitrofanov, V. .p., Mitselmakher, G., Mittleman, R., Moggi, A., Mohan, M., Mohapatra, S. .r. .p., MONTANI, MATTEO, Moore, B. .c., Moore, C. .j., Moraru, D., Moreno, G., Morriss, S. .r., Mossavi, K., Mours, B., Mow Lowry, C. .m., Mueller, G., Muir, A. .w., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukund, N., Mullavey, A., Munch, J., Murphy, D. .j., Murray, P. .g., Mytidis, A., Nardecchia, I., Naticchioni, L., Nayak, R. .k., Nedkova, K., Nelemans, G., Nelson, T. .j. .n., Neri, M., Neunzert, A., Newton, G., Nguyen, T. .t., Nielsen, A. .b., Nissanke, S., Nitz, A., Nocera, F., Nolting, D., Normandin, M. .e. .n., Nuttall, L. .k., Oberling, J., Ochsner, E., O’Dell, J., Oelker, E., Ogin, G. .h., Oh, J. .j., Oh, S. .h., Ohme, F., Oliver, M., Oppermann, P., Oram, Richard J., O’Reilly, B., O’Shaughnessy, R., Ottaway, D. .j., Overmier, H., Owen, B. .j., Pai, A., Pai, S. .a., Palamos, J. .r., Palashov, O., Palomba, C., Pal Singh, A., Pan, H., Pankow, C., Pannarale, F., Pant, B. .c., Paoletti, F., Paoli, A., Papa, M. .a., Paris, H. .r., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patricelli, B., Patrick, Z., Pearlstone, B. .l., Pedraza, M., Pedurand, R., Pekowsky, L., Pele, A., Penn, S., Perreca, A., Perri, L. .m., Pfeiffer, H. .p., Phelps, M., Piccinni, O. .j., Pichot, M., PIERGIOVANNI, FRANCESCO, Pierro, V., Pillant, G., Pinard, L., Pinto, I. .m., Pitkin, M., Poe, M., Poggiani, R., Popolizio, P., Post, A., Powell, J., Prasad, J., Predoi, V., Prestegard, T., Price, L. .r., Prijatelj, M., Principe, M., Privitera, S., Prix, R., Prodi, G. .a., Prokhorov, L., Puncken, O., Punturo, M., Puppo, P., Pürrer, M., Qi, H., Qin, J., Qiu, S., Quetschke, V., Quintero, E. .a., Quitzow James, R., Raab, F. .j., Rabeling, D. .s., Radkins, H., Raffai, P., Raja, S., Rajan, C., Rakhmanov, M., Rapagnani, P., Raymond, V., Razzano, M., Re, V., Read, J., Reed, C. .m., Regimbau, T., Rei, L., Reid, S., Reitze, D. .h., Rew, H., Reyes, S. .d., Ricci, F., Riles, K., Rizzo, M., Robertson, N. .a., Robie, R., Robinet, F., Rocchi, A., Rolland, L., Rollins, J. .g., Roma, V. .j., Romano, R., Romanov, G., Romie, J. .h., Rosińska, D., Rowan, S., Rüdiger, A., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadeghian, L., Sakellariadou, M., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sammut, L., Sanchez, E. .j., Sandberg, V., Sandeen, B., Sanders, J. .r., Sassolas, B., Sathyaprakash, B. .s., Saulson, P. .r., Sauter, O. .e. .s., Savage, R. .l., Sawadsky, A., Schale, P., Schilling, R., Schmidt, J., Schmidt, P., Schnabel, R., Schofield, R. .m. .s., Schönbeck, A., Schreiber, E., Schuette, D., Schutz, B. .f., Scott, J., Scott, S. .m., Sellers, D., Sengupta, A. .s., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaddock, D. .a., Shaffer, T., Shahriar, M. .s., Shaltev, M., Shapiro, B., Shawhan, P., Sheperd, A., Shoemaker, D. .h., Shoemaker, D. .m., Siellez, K., Siemens, X., Sieniawska, M., Sigg, D., Silva, A. .d., Singer, A., Singer, L. .p., Singh, A., Singh, R., Singhal, A., Sintes, A. .m., Slagmolen, B. .j. .j., Smith, J. .r., Smith, N. .d., Smith, R. .j. .e., Son, E. .j., Sorazu, B., Sorrentino, F., Souradeep, T., Srivastava, A. .k., Staley, A., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stephens, B. .c., Stevenson, S. .p., Stone, R., Strain, K. .a., Straniero, N., STRATTA, MARIA GIULIANA, Strauss, N. .a., Strigin, S., Sturani, R., Stuver, A. .l., Summerscales, T. .z., Sun, L., Sunil, S., Sutton, P. .j., Swinkels, B. .l., Szczepańczyk, M. .j., Tacca, M., Talukder, D., Tanner, D. .b., Tápai, M., Tarabrin, S. .p., Taracchini, A., Taylor, R., Theeg, T., Thirugnanasambandam, M. .p., Thomas, E. .g., Thomas, M., Thomas, P., Thorne, K. .a., Thorne, K. .s., Thrane, E., Tiwari, S., Tiwari, V., Tokmakov, K. .v., Toland, K., Tomlinson, C., Tonelli, M., Tornasi, Z., Torres, C. .v., Torrie, C. .i., Töyrä, D., Travasso, F., Traylor, G., Trifirò, D., Tringali, M. .c., Trozzo, L., Tse, M., Turconi, M., Tuyenbayev, D., Ugolini, D., Unnikrishnan, C. .s., Urban, A. .l., Usman, S. .a., Vahlbruch, H., Vajente, G., Valdes, G., Vallisneri, M., van Bakel, N., van Beuzekom, M., van den Brand, J. .f. .j., Van Den Broeck, C., Vander Hyde, D. .c., van der Schaaf, L., van der Sluys, M. .v., van Heijningen, J. .v., Vano Vinuales, A., van Veggel, A. .a., Vardaro, M., Vass, S., Vasúth, M., Vaulin, R., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. .j., Venkateswara, K., Verkindt, D., VETRANO, FLAVIO, VICERE', ANDREA, Vinciguerra, S., Vine, D. .j., Vinet, J. Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Voss, D. .v., Vousden, W. .d., Vyatchanin, S. .p., Wade, A. .r., Wade, L. .e., Wade, M., Walker, M., Wallace, L., Walsh, S., Wang, G., Wang, H., Wang, M., Wang, X., Wang, Y., Ward, R. .l., Warner, J., Was, M., Weaver, B., Wei, L. W., Weinert, M., Weinstein, A. .j., Weiss, R., Wen, L., Weßels, P., Westphal, T., Wette, K., Whelan, J. .t., Whiting, B. .f., Williams, R. .d., Williamson, A. .r., Willis, J. .l., Willke, B., Wimmer, M. .h., Winkler, W., Wipf, C. .c., Wittel, H., Woan, G., Woehler, J., Worden, J., Wright, J. .l., Wu, D. .s., Wu, G., Yablon, J., Yam, W., Yamamoto, H., Yancey, C. .c., Yu, H., Yvert, M., Zadrożny, A., Zangrando, L., Zanolin, M., Zendri, J. P., Zevin, M., Zhang, L., Zhang, M., Zhang, Y., Zhao, C., Zhou, M., Zhou, Z., Zhu, X. .j., Zucker, M. .e., Zuraw, S. .e., Zweizig, J., Boyle, M., Brügmann, B., Campanelli, M., Chu, T., Clark, M., Haas, R., Hemberger, D., Hinder, I., Kidder, L. .e., Kinsey, M., Laguna, P., Ossokine, S., Pan, Y., Röver, C., Scheel, M., Szilagyi, B., Teukolsky, S., and Zlochower, Y.
Subjects: Astrophysics, Gravitation, GW150914, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], waveform modelling, QC1-999, Astronomy, Posterior probability, General Relativity and Quantum Cosmology, astro-ph.HE, GRAVITATIONAL-RADIATION, Gravitational Wave, Binary number, FOS: Physical sciences, General Physics and Astronomy, General Relativity and Quantum Cosmology (gr-qc), 01 natural sciences, [ PHYS.GRQC ] Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Physics and Astronomy (all), GW spin, Settore FIS/05 - Astronomia e Astrofisica, Observatory, Improved Analysis, 0103 physical sciences, Waveform, 010306 general physics, QC, QB, Gravitational Waves, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, Estimation theory, Settore FIS/01 - Fisica Sperimentale, [ PHYS.ASTR.HE ] Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], binary black hole, Gravitational Waves, GW150914, Improved Analysis, LIGO, Computational physics, Interferometry, Physics and Astronomy, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Astrophysics - High Energy Astrophysical Phenomena, Dimensionless quantity, Sciences exactes et naturelles
Abstract: This paper presents updated estimates of source parameters for GW150914, a binary black-hole coalescence event detected by the Laser Interferometer Gravitational-wave Observatory (LIGO) in 2015 [Abbott et al. Phys. Rev. Lett. 116, 061102 (2016).]. Abbott et al. [Phys. Rev. Lett. 116, 241102 (2016).] presented parameter estimation of the source using a 13-dimensional, phenomenological precessing-spin model (precessing IMRPhenom) and an 11-dimensional nonprecessing effective-one body (EOB) model calibrated to numerical-relativity simulations, which forces spin alignment (nonprecessing EOBNR). Here, we present new results that include a 15-dimensional precessingspin waveform model (precessing EOBNR) developed within the EOB formalism. We find good agreement with the parameters estimated previously [Abbott et al. Phys. Rev. Lett. 116, 241102 (2016).], and we quote updated component masses of 35 +5 -3 M· and 30 +5 -3 M· (where errors correspond to 90% symmetric credible intervals). We also present slightly tighter constraints on the dimensionless spin magnitudes of the two black holes, with a primary spin estimate < 0.65 and a secondary spin estimate < 0.75 at 90% probability. Abbott et al. [Phys. Rev. Lett. 116, 241102 (2016).] estimated the systematic parameter-extraction errors due to waveform-model uncertainty by combining the posterior probability densities of precessing IMRPhenom and nonprecessing EOBNR. Here, we find that the two precessing-spin models are in closer agreement, suggesting that these systematic errors are smaller than previously quoted, 0, info:eu-repo/semantics/published
Published: 2016
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13. Analysis and algorithms: An optimization framework for joint sensor deployment, link scheduling and routing in underwater sensor networks

Author: Badia, L., Mastrogiovanni, M., Petrioli, C., Stefanakos, S., and Zorzi, Michele
Published: 2006

14. Bridging the gap between high school and university mathematics

Author: Accascina, Giuseppe, Mastrogiovanni, M., and Rogora, Enrico
Published: 2004

15. Localized protocols for ad hoc clustering and backbone formation: a performance comparison

Author: Basagni, S., primary, Mastrogiovanni, M., additional, Panconesi, A., additional, and Petrioli, C., additional
Published: 2006
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16. An optimization framework for joint sensor deployment, link scheduling and routing in underwater sensor networks

Author: Badia, L., primary, Mastrogiovanni, M., additional, Petrioli, C., additional, Stefanakos, S., additional, and Zorzi, M., additional
Published: 2006
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17. JAMES: JAva test-bed ManagEment System.

Author: Mastrogiovanni, M., Modesti, A., and Petrioli, C.
Published: 2009
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18. The Design, Deployment, and Analysis of SignetLab: A Sensor Network Testbed and Interactive Management Tool.

Author: Crepaldi, R., Friso, S., Harris, A., Mastrogiovanni, M., Petrioli, C., Rossi, M., Zanella, A., and Zorzi, M.
Published: 2007
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19. WSN19-6: Integrated Data Delivery and Interest Dissemination Techniques for Wireless Sensor Networks.

Author: Mastrogiovanni, M., Petrioli, C., Rossi, M., Vitaletti, A., and Zorzi, M.
Published: 2006
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20. A performance comparison of protocols for clustering and backbone formation in large scale ad hoc networks.

Author: Basagni, S., Mastrogiovanni, M., and Petrioli, C.
Published: 2004
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21. A performance comparison of protocols for clustering and backbone formation in large scale ad hoc networks

Author: Basagni, S., primary, Mastrogiovanni, M., additional, and Petrioli, C., additional
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22. CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter

Author: Martina Kunkl, Marta Mastrogiovanni, Nicla Porciello, Silvana Caristi, Emanuele Monteleone, Stefano Arcieri, Loretta Tuosto, Kunkl, M., Mastrogiovanni, M., Porciello, N., Caristi, S., Monteleone, E., Arcieri, S., and Tuosto, L.
Subjects: 0301 basic medicine, CD4-Positive T-Lymphocytes, STAT3 Transcription Factor, Transcriptional Activation, lcsh:Immunologic diseases. Allergy, CD28, T-Lymphocytes, Immunology, Receptors, Antigen, T-Cell, T lymphocytes, Biology, STAT3, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, IL-17 A, NF-kappa B, CD28 Antigens, Gene expression, Immunology and Allergy, Humans, Receptor, Promoter Regions, Genetic, Transcription factor, PI3K/AKT/mTOR pathway, Original Research, Binding Sites, Base Sequence, Interleukin-6, Interleukin-17, Transcription Factor RelA, NF-κB, NFKB1, Cell biology, 030104 developmental biology, chemistry, Gene Expression Regulation, biology.protein, Cytokines, lcsh:RC581-607, 030215 immunology, Protein Binding, Signal Transduction
Abstract: CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. We have recently reported that CD28 autonomous signaling induces the expression of IL-17A in peripheral CD4+ T lymphocytes from healthy donors, multiple sclerosis, and type 1 diabetes patients. Due to the relevance of IL-17A in the pathophysiology of several inflammatory and autoimmune diseases, we characterized the mechanisms and signaling mediators responsible for CD28-induced IL-17A expression. Here we show that CD28-mediated up-regulation of IL-17A gene expression depends on RelA/NF-κB and IL-6-associated STAT3 transcriptions factors. In particular, we found that CD28-activated RelA/NF-κB induces the expression of IL-6 that, in a positive feedback loop, mediates the activation and nuclear translocation of tyrosine phosphorylated STAT3 (pSTAT3). pSTAT3 in turn cooperates with RelA/NF-κB by binding specific sequences within the proximal promoter of human IL-17A gene, thus inducing its expression. Finally, by using specific inhibitory drugs, we also identified class 1A phosphatidylinositol 3-kinase (PI3K) as a critical upstream regulator of CD28-mediated RelA/NF-κB and STAT3 recruitments and trans-activation of IL-17A promoter. Our findings reveal a novel mechanism by which human CD28 may amplify IL-17A expression in human T lymphocytes and provide biological bases for immunotherapeutic approaches targeting CD28-associated class 1A PI3K to dampen IL-17A-mediated inflammatory response in autoimmune/inflammatory disorders.
Published: 2019
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23. Subverting Attachment to Prevent Attacking : Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion.

Author: Mastrogiovanni M, Donnadieu E, Pathak R, and Di Bartolo V
Abstract: Cell adhesion regulates specific migratory patterns, location, communication with other cells, physical interactions with the extracellular matrix, and the establishment of effector programs. Proper immune control of cancer strongly depends on all these events occurring in a highly accurate spatiotemporal sequence. In response to cancer-associated inflammatory signals, effector immune cells navigating the bloodstream shift from their patrolling exploratory migration mode to establish adhesive interactions with vascular endothelial cells. This interaction enables them to extravasate through the blood vessel walls and access the cancer site. Further adhesive interactions within the tumor microenvironment (TME) are crucial for coordinating their distribution in situ and for mounting an effective anti-tumor immune response. In this review, we examine how alterations of adhesion cues in the tumor context favor tumor escape by affecting effector immune cell infiltration and trafficking within the TME. We discuss the mechanisms by which tumors directly modulate immune cell adhesion and migration patterns to affect anti-tumor immunity and favor tumor evasion. We also explore indirect immune escape mechanisms that involve modifications of TME characteristics, such as vascularization, immunogenicity, and structural topography. Finally, we highlight the significance of these aspects in designing more effective drug treatments and cellular immunotherapies.
Published: 2024
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24. Tomato pomace-derived nitrated fatty acids: Synthesis and antiplatelet activity.

Author: Rodríguez L, Lagos F, Mastrogiovanni M, Flores A, Plaza A, Telleria F, Palomo I, Fuentes E, and Trostchansky A
Abstract: This study investigates the antiplatelet properties of tomato pulp to combat cardiovascular diseases. Notably, it examines the formation of nitrated fatty acids (NO 2 -FA) in tomato pomace, renowned for its potential antiplatelet effects. Through diverse assays, including tandem mass spectrometry, microplate-based platelet aggregation, and flow cytometry, the research identifies NO 2 -OA, NO 2 -LA, and NO 2 -LnA as pivotal antiplatelet compounds. It demonstrates the concentration-dependent antiplatelet effects of nitrated tomato pomace against thrombin receptor activator peptide 6 (TRAP-6) and collagen-induced platelet activation, alongside the modulation of platelet activation markers. Additionally, synergistic effects were observed with nitrated tomato pomace extracts. The findings suggest therapeutic potential for NO 2 -FA derived from tomato pomace in preventing blood clot formation, with nitrated extracts exhibiting superior efficacy compared to non-nitrated ones. This research highlights the promising role of natural products, such as tomato pomace, in mitigating cardiovascular risks and proposes novel strategies for population health enhancement and cardiovascular disease management., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Published: 2024
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25. Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids.

Author: Bonnet V, Maikranz E, Madec M, Vertti-Quintero N, Cuche C, Mastrogiovanni M, Alcover A, Di Bartolo V, and Baroud CN
Subjects: Humans, T-Lymphocytes, Cytotoxic, Mutation, Lab-On-A-Chip Devices, Adenomatous Polyposis Coli, Neoplasms genetics
Abstract: Evaluating the ability of cytotoxic T lymphocytes (CTLs) to eliminate tumor cells is crucial, for instance, to predict the efficiency of cell therapy in personalized medicine. However, the destruction of a tumor by CTLs involves CTL migration in the extra-tumoral environment, accumulation on the tumor, antigen recognition, and cooperation in killing the cancer cells. Therefore, identifying the limiting steps in this complex process requires spatio-temporal measurements of different cellular events over long periods. Here, we use a cancer-on-a-chip platform to evaluate the impact of adenomatous polyposis coli (APC) mutation on CTL migration and cytotoxicity against 3D tumor spheroids. The APC mutated CTLs are found to have a reduced ability to destroy tumor spheroids compared with control cells, even though APC mutants migrate in the extra-tumoral space and accumulate on the spheroids as efficiently as control cells. Once in contact with the tumor however, mutated CTLs display reduced engagement with the cancer cells, as measured by a metric that distinguishes different modes of CTL migration. Realigning the CTL trajectories around localized killing cascades reveals that all CTLs transition to high engagement in the 2 h preceding the cascades, which confirms that the low engagement is the cause of reduced cytotoxicity. Beyond the study of APC mutations, this platform offers a robust way to compare cytotoxic cell efficiency of even closely related cell types, by relying on a multiscale cytometry approach to disentangle complex interactions and to identify the steps that limit the tumor destruction., Competing Interests: Competing interests statement:C.N.B. is named inventor on several patents related to the technology. C.N.B. is also co-founder of the spinoff company Okomera. The remaining authors declare no competing interest.
Published: 2024
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26. Inflammation in Development and Aging: Insights from the Zebrafish Model.

Author: Mastrogiovanni M, Martínez-Navarro FJ, Bowman TV, and Cayuela ML
Subjects: Animals, Humans, Models, Animal, Aging genetics, Signal Transduction, Zebrafish genetics, Inflammation
Abstract: Zebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host defense, immune responses, and tissue regeneration. Additionally, the zebrafish model system facilitates prompt screening of chemical compounds that affect inflammation. This study explored the diverse roles of inflammatory pathways in zebrafish development and aging. Serving as a crucial model, zebrafish provides insights into the intricate interplay of inflammation in both developmental and aging contexts. The evidence presented suggests that the same inflammatory signaling pathways often play instructive or beneficial roles during embryogenesis and are associated with malignancies in adults.
Published: 2024
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27. The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer's Disease-like Pathogenesis.

Author: Galeano P, de Ceglia M, Mastrogiovanni M, Campanelli L, Medina-Vera D, Campolo N, Novack GV, Rosell-Valle C, Suárez J, Aicardo A, Campuzano K, Castaño EM, Do Carmo S, Cuello AC, Bartesaghi S, Radi R, Rodríguez de Fonseca F, and Morelli L
Subjects: Mice, Rats, Animals, Brain pathology, Mice, Transgenic, Amyloid, Disease Models, Animal, Rats, Transgenic, Diet, High-Fat, Alzheimer Disease genetics, Alzheimer Disease pathology, Fatty Acids, Omega-3
Abstract: This work aims to clarify the effect of dietary polyunsaturated fatty acid (PUFA) intake on the adult brain affected by amyloid pathology. McGill-R-Thy1-APP transgenic (Tg) rat and 5xFAD Tg mouse models that represent earlier or later disease stages were employed. The animals were exposed to a control diet (CD) or an HFD based on corn oil, from young (rats) or adult (mice) ages for 24 or 10 weeks, respectively. In rats and mice, the HFD impaired reference memory in wild-type (WT) animals but did not worsen it in Tg, did not cause obesity, and did not increase triglycerides or glucose levels. Conversely, the HFD promoted stronger microglial activation in Tg vs. WT rats but had no effect on cerebral amyloid deposition. IFN-γ, IL-1β, and IL-6 plasma levels were increased in Tg rats, regardless of diet, while CXCL1 chemokine levels were increased in HFD-fed mice, regardless of genotype. Hippocampal 3-nitrotyrosine levels tended to increase in HFD-fed Tg rats but not in mice. Overall, an HFD with an elevated omega-6-to-omega-3 ratio as compared to the CD (25:1 vs. 8.4:1) did not aggravate the outcome of AD regardless of the stage of amyloid pathology, suggesting that many neurobiological processes relevant to AD are not directly dependent on PUFA intake.
Published: 2023
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28. 4-Hydroxynonenal impairs miRNA maturation in heart failure via Dicer post-translational modification.

Author: Kiyuna LA, Candido DS, Bechara LRG, Jesus ICG, Ramalho LS, Krum B, Albuquerque RP, Campos JC, Bozi LHM, Zambelli VO, Alves AN, Campolo N, Mastrogiovanni M, Bartesaghi S, Leyva A, Durán R, Radi R, Arantes GM, Cunha-Neto E, Mori MA, Chen CH, Yang W, Mochly-Rosen D, MacRae IJ, Ferreira LRP, and Ferreira JCB
Subjects: Humans, Rats, Animals, Ribonuclease III genetics, Ribonuclease III metabolism, Aldehydes metabolism, Aldehydes pharmacology, Protein Processing, Post-Translational, Aldehyde Dehydrogenase, Mitochondrial genetics, MicroRNAs metabolism, Heart Failure
Abstract: Background and Aims: Developing novel therapies to battle the global public health burden of heart failure remains challenging. This study investigates the underlying mechanisms and potential treatment for 4-hydroxynonenal (4-HNE) deleterious effects in heart failure., Methods: Biochemical, functional, and histochemical measurements were applied to identify 4-HNE adducts in rat and human failing hearts. In vitro studies were performed to validate 4-HNE targets., Results: 4-HNE, a reactive aldehyde by-product of mitochondrial dysfunction in heart failure, covalently inhibits Dicer, an RNase III endonuclease essential for microRNA (miRNA) biogenesis. 4-HNE inhibition of Dicer impairs miRNA processing. Mechanistically, 4-HNE binds to recombinant human Dicer through an intermolecular interaction that disrupts both activity and stability of Dicer in a concentration- and time-dependent manner. Dithiothreitol neutralization of 4-HNE or replacing 4-HNE-targeted residues in Dicer prevents 4-HNE inhibition of Dicer in vitro. Interestingly, end-stage human failing hearts from three different heart failure aetiologies display defective 4-HNE clearance, decreased Dicer activity, and miRNA biogenesis impairment. Notably, boosting 4-HNE clearance through pharmacological re-activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2) using Alda-1 or its improved orally bioavailable derivative AD-9308 restores Dicer activity. ALDH2 is a major enzyme responsible for 4-HNE removal. Importantly, this response is accompanied by improved miRNA maturation and cardiac function/remodelling in a pre-clinical model of heart failure., Conclusions: 4-HNE inhibition of Dicer directly impairs miRNA biogenesis in heart failure. Strikingly, decreasing cardiac 4-HNE levels through pharmacological ALDH2 activation is sufficient to re-establish Dicer activity and miRNA biogenesis; thereby representing potential treatment for patients with heart failure., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Published: 2023
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29. Photochemically-induced protein tyrosine nitration in vitro and in cellula by 5-methyl-1,4-dinitro-1H-imidazole (DNI): synthesis and biochemical characterization.

Author: Rios N, Aicardo A, Chavarría C, Ivagnes R, Mastrogiovanni M, Radi R, and Souza JM
Subjects: Animals, Cattle, Tyrosine metabolism, Nitrates metabolism, Imidazoles, Nitrogen Dioxide, Endothelial Cells metabolism
Abstract: The photochemical nitrating agent 5-methyl-1,4-dinitro-1H-imidazole (DNI) has been recently described as an effective tool for nitrating tyrosine residues in proteins under 390 nm irradiation (Long T. et al., 2021). Herein, we describe the one-step synthesis of DNI from the precursor 4-methyl-5-nitro-1H-imidazole with good yield (66%) and high purity (>99%). Spectral analysis of DNI reveals two maximum peaks (228 and 290 nm) with maximum nitration yields and kinetics occurring at 290 nm. Electron paramagnetic resonance (EPR)- and mass spectrometry (MS)- spin trapping analysis evidenced the formation of nitrogen dioxide ( • NO 2 ) upon irradiation of DNI, implying the homolysis of the N-N bond in the DNI molecule. Irradiation of DNI at 290, 390 nm, or UVA light (315-400 nm), produced tyrosine nitration, with yields approaching ca. 30% with respect to DNI at 290 nm exposure. Indeed, using alpha-synuclein as a model protein, the main protein post-translational modification triggered by DNI was the generation of 3-nitrotyrosine as shown by MS analysis. Additionally, the formation of di-tyrosine was also observed. Finally, intracellular • NO 2 production upon DNI photolysis in bovine aortic endothelial cells was evidenced by the nitration of the tyrosine analog probe p-hydroxyphenylacetic acid (PHPA) and cellular protein tyrosine nitration., Competing Interests: Declaration of competing interest The authors declared no conflict or competing interest., (Copyright © 2023 Elsevier Inc. All rights reserved.)
Published: 2023
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30. Disulfides form persulfides at alkaline pH leading to potential overestimations in the cold cyanolysis method.

Author: Benchoam D, Cuevasanta E, Semelak JA, Mastrogiovanni M, Estrin DA, Möller MN, and Alvarez B
Subjects: Glutathione Disulfide, Sulfur Compounds metabolism, Hydrogen-Ion Concentration, Sulfur metabolism, Disulfides metabolism
Abstract: It is well established that proteins and peptides can release sulfur under alkaline treatment, mainly through the β-elimination of disulfides with the concomitant formation of persulfides and dehydroalanine derivatives. In this study, we evaluated the formation of glutathione persulfide (GSSH/GSS - ) by exposure of glutathione disulfide (GSSG) to alkaline conditions. The kinetics of the reaction between GSSG and HO - was investigated by UV-Vis absorbance, reaction with 5,5'-dithio-bis-(2-nitrobenzoic acid) (DTNB), and cold cyanolysis, obtaining an apparent second-order rate constant of ∼10 -3 M -1 s -1 at 25 °C. The formation of GSSH and the dehydroalanine derivative was confirmed by HPLC and/or mass spectrometry. However, the mixtures did not equilibrate in a timescale of hours, and additional species, including thiol and diverse sulfane sulfur compounds were also formed, probably through further reactions of the persulfide. Cold cyanolysis is frequently used to quantify persulfides, since it measures sulfane sulfur. This method involves a step in which the sample to be analyzed is incubated with cyanide at alkaline pH. When cold cyanolysis was applied to samples containing GSSG, sulfane sulfur products that were not present in the original sample were measured. Thus, our results reveal the risk of overestimating the amount of sulfane sulfur compounds in samples that contain disulfides due to their decay to persulfides and other sulfane sulfur compounds at alkaline pH. Overall, our study highlights that the β-elimination of disulfides is a potential source of persulfides, although we do not recommend the preparation of GSSH from incubation of GSSG in alkali. Our study also highlights the importance of being cautious when doing and interpreting cold cyanolysis experiments., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Inc.)
Published: 2023
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31. T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations.

Author: Cuche C, Mastrogiovanni M, Juzans M, Laude H, Ungeheuer MN, Krentzel D, Gariboldi MI, Scott-Algara D, Madec M, Goyard S, Floch C, Chauveau-Le Friec G, Lafaye P, Renaudat C, Le Bidan M, Micallef C, Schmutz S, Mella S, Novault S, Hasan M, Duffy D, Di Bartolo V, and Alcover A
Subjects: Humans, Genes, APC, Pilot Projects, Mutation, Cell Movement genetics, Adenomatous Polyposis Coli genetics, Adenomatous Polyposis Coli pathology, Colorectal Neoplasms genetics
Abstract: Familial adenomatous polyposis (FAP) is an inherited disease characterized by the development of large number of colorectal adenomas with high risk of evolving into colorectal tumors. Mutations of the Adenomatous polyposis coli (APC) gene is often at the origin of this disease, as well as of a high percentage of spontaneous colorectal tumors. APC is therefore considered a tumor suppressor gene. While the role of APC in intestinal epithelium homeostasis is well characterized, its importance in immune responses remains ill defined. Our recent work indicates that the APC protein is involved in various phases of both CD4 and CD8 T cells responses. This prompted us to investigate an array of immune cell features in FAP subjects carrying APC mutations. A group of 12 FAP subjects and age and sex-matched healthy controls were studied. We characterized the immune cell repertoire in peripheral blood and the capacity of immune cells to respond ex vivo to different stimuli either in whole blood or in purified T cells. A variety of experimental approaches were used, including, pultiparamater flow cytometry, NanosString gene expression profiling, Multiplex and regular ELISA, confocal microscopy and computer-based image analyis methods. We found that the percentage of several T and natural killer (NK) cell populations, the expression of several genes induced upon innate or adaptive immune stimulation and the production of several cytokines and chemokines was different. Moreover, the capacity of T cells to migrate in response to chemokine was consistently altered. Finally, immunological synapses between FAP cytotoxic T cells and tumor target cells were more poorly structured. Our findings of this pilot study suggest that mild but multiple immune cell dysfunctions, together with intestinal epithelial dysplasia in FAP subjects, may facilitate the long-term polyposis and colorectal tumor development. Although at an initial discovery phase due to the limited sample size of this rare disease cohort, our findings open new perspectives to consider immune cell abnormalities into polyposis pathology., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Cuche, Mastrogiovanni, Juzans, Laude, Ungeheuer, Krentzel, Gariboldi, Scott-Algara, Madec, Goyard, Floch, Chauveau-Le Friec, Lafaye, Renaudat, Le Bidan, Micallef, Schmutz, Mella, Novault, Hasan, Duffy, Di Bartolo and Alcover.)
Published: 2023
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32. Energy, protein and redox metabolism underlying adaptive responses in New Zealand versus North American Holstein cows in pasture-based dairy systems.

Author: Jorge-Smeding E, Carriquiry M, Casal A, Armand-Ugon D, Mastrogiovanni M, Trotschansky A, Mendoza A, and Astessiano AL
Subjects: Female, Cattle, Animals, New Zealand, Milk metabolism, Lactation physiology, Insulin, Oxidation-Reduction, North America, Superoxide Dismutase metabolism, Energy Metabolism, Diet veterinary, alpha-Tocopherol metabolism
Abstract: This study explored the metabolic adaptions to grazing conditions of two Holstein genetic strains (GS; North American, NAH; New Zealand, NZH) in two feeding strategies (FS; restricted, P30, vs. maximised, PMAX, grazing). Four groups (NAH-P30, NZH-P30, NAH-PMAX and NZH-PMAX; n = 10 cows each) were compared between -45 and 180 days in milk (DIM). NZH cows had lower (p = 0.02) fat and protein corrected milk (FPCM) yield and a tendency for lower (p = 0.09) body condition score concomitantly with a trend (p < 0.07) for higher average plasma insulin and lower (p = 0.01) 3-methylhistidine (3MH) at -45 DIM than NAH. Plasma glucose tended to be affected by the triple interaction GS × FS × DIM (p = 0.06) as it was similar between NAH-P30 and NZH-P30, but higher (p ≤ 0.02) for NZH-PMAX than NAH-PMAX except at 21 DIM. The physiological imbalance index was affected by the GS × FS interaction (p < 0.01) as it was lower (p < 0.01) only for NZH-PMAX versus NAH-PMAX. NZH cows had higher (p = 0.01) plasma thiobarbituric acid reactive substances at -45 DIM and tended to have higher protein carbonyls (p = 0.10) and superoxide dismutase (SOD) activity (p = 0.06) on average, and had higher (p < 0.01) α-tocopherol during mid-lactation than NAH Regarding the FS, FPCM was similar (p = 0.12) among them, but PMAX cows had higher (p < 0.01) plasma non-esterified fatty acids and 3MH, and lower insulin (p < 0.01) than P30 at 100 DIM. PMAX cows showed higher average SOD activity (p = 0.01) and plasma α-tocopherol at 100 and 180 DIM (p < 0.01). Under grazing, NZH cows can have a better energy status and lower muscle mobilisation but a higher redox reactivity. Maximising grazing can worsen energy status and muscle mobilisation while improving antioxidant response with no effect on FPCM., (© 2022 Wiley-VCH GmbH.)
Published: 2023
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33. Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation.

Author: Campolo N, Mastrogiovanni M, Mariotti M, Issoglio FM, Estrin D, Hägglund P, Grune T, Davies MJ, Bartesaghi S, and Radi R
Subjects: Humans, Chromatography, Liquid, Tandem Mass Spectrometry, Tyrosine metabolism, Enzyme Activation drug effects, Oxidation-Reduction, Mutation, Protein Aggregation, Pathological chemically induced, Glutamate-Ammonia Ligase genetics, Glutamate-Ammonia Ligase metabolism, Peroxynitrous Acid chemistry, Peroxynitrous Acid pharmacology, Protein Processing, Post-Translational
Abstract: Glutamine synthetase (GS), which catalyzes the ATP-dependent synthesis of L-glutamine from L-glutamate and ammonia, is a ubiquitous and conserved enzyme that plays a pivotal role in nitrogen metabolism across all life domains. In vertebrates, GS is highly expressed in astrocytes, where its activity sustains the glutamate-glutamine cycle at glutamatergic synapses and is thus essential for maintaining brain homeostasis. In fact, decreased GS levels or activity have been associated with neurodegenerative diseases, with these alterations attributed to oxidative post-translational modifications of the protein, in particular tyrosine nitration. In this study, we expressed and purified human GS (HsGS) and performed an in-depth analysis of its oxidative inactivation by peroxynitrite (ONOO - ) in vitro. We found that ONOO - exposure led to a dose-dependent loss of HsGS activity, the oxidation of cysteine, methionine, and tyrosine residues and also the nitration of tryptophan and tyrosine residues. Peptide mapping by LC-MS/MS through combined H 2 16 O/H 2 18 O trypsin digestion identified up to 10 tyrosine nitration sites and five types of dityrosine cross-links; these modifications were further scrutinized by structural analysis. Tyrosine residues 171, 185, 269, 283, and 336 were the main nitration targets; however, tyrosine-to-phenylalanine HsGS mutants revealed that their sole nitration was not responsible for enzyme inactivation. In addition, we observed that ONOO - induced HsGS aggregation and activity loss. Thiol oxidation was a key modification to elicit aggregation, as it was also induced by hydrogen peroxide treatment. Taken together, our results indicate that multiple oxidative events at various sites are responsible for the inactivation and aggregation of human GS., Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the content of this article., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2023
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34. Mitochondrial Peroxiredoxin 3 Is Rapidly Oxidized and Hyperoxidized by Fatty Acid Hydroperoxides.

Author: Cardozo G, Mastrogiovanni M, Zeida A, Viera N, Radi R, Reyes AM, and Trujillo M
Abstract: Human peroxiredoxin 3 ( Hs Prx3) is a thiol-based peroxidase responsible for the reduction of most hydrogen peroxide and peroxynitrite formed in mitochondria. Mitochondrial disfunction can lead to membrane lipoperoxidation, resulting in the formation of lipid-bound fatty acid hydroperoxides ( L FA-OOHs) which can be released to become free fatty acid hydroperoxides ( f FA-OOHs). Herein, we report that Hs Prx3 is oxidized and hyperoxidized by f FA-OOHs including those derived from arachidonic acid and eicosapentaenoic acid peroxidation at position 15 with remarkably high rate constants of oxidation (>3.5 × 10 7 M -1 s -1 ) and hyperoxidation (~2 × 10 7 M -1 s -1 ). The endoperoxide-hydroperoxide PGG 2 , an intermediate in prostanoid synthesis, oxidized Hs Prx3 with a similar rate constant, but was less effective in causing hyperoxidation. Biophysical methodologies suggest that Hs Prx3 can bind hydrophobic structures. Indeed, molecular dynamic simulations allowed the identification of a hydrophobic patch near the enzyme active site that can allocate the hydroperoxide group of f FA-OOHs in close proximity to the thiolate in the peroxidatic cysteine. Simulations performed using available and herein reported kinetic data indicate that Hs Prx3 should be considered a main target for mitochondrial f FA-OOHs. Finally, kinetic simulation analysis support that mitochondrial f FA-OOHs formation fluxes in the range of nM/s are expected to contribute to Hs Prx3 hyperoxidation, a modification that has been detected in vivo under physiological and pathological conditions.
Published: 2023
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35. Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability.

Author: Calì B, Deygas M, Munari F, Marcuzzi E, Cassará A, Toffali L, Vetralla M, Bernard M, Piel M, Gagliano O, Mastrogiovanni M, Laudanna C, Elvassore N, Molon B, Vargas P, and Viola A
Subjects: Mice, Animals, Cell Movement, Signal Transduction, Chromatin, Neutrophils, Cell Nucleus
Abstract: To reach inflamed tissues from the circulation, neutrophils must overcome physical constraints imposed by the tissue architecture, such as the endothelial barrier or the three-dimensional (3D) interstitial space. In these microenvironments, neutrophils are forced to migrate through spaces smaller than their own diameter. One of the main challenges for cell passage through narrow gaps is the deformation of the nucleus, the largest and stiffest organelle in cells. Here, we showed that chemokines, the extracellular signals that guide cell migration in vivo, modulated nuclear plasticity to support neutrophil migration in restricted microenvironments. Exploiting microfabricated devices, we found that the CXC chemokine CXCL12 enhanced the nuclear pliability of mouse bone marrow-derived neutrophils to sustain their migration in 3D landscapes. This previously uncharacterized function of CXCL12 was mediated by the atypical chemokine receptor ACKR3 (also known as CXCR7), required protein kinase A (PKA) activity, and induced chromatin compaction, which resulted in enhanced cell migration in 3D. Thus, we propose that chemical cues regulate the nuclear plasticity of migrating leukocytes to optimize their motility in restricted microenvironments.
Published: 2022
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36. Corrigendum to "Fast and biphasic 8-nitroguanine production from guanine and peroxynitrite" [Free Radic. Biol. Med. 193 (2022) 474-484].

Author: Sánchez AG, Ibargoyen MN, Mastrogiovanni M, Radi R, Keszenman DJ, and Peluffo RD
Published: 2022
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37. Fast and biphasic 8-nitroguanine production from guanine and peroxynitrite.

Author: Sánchez AG, Ibargoyen MN, Mastrogiovanni M, Radi R, Keszenman DJ, and Peluffo RD
Subjects: Nitrates chemistry, Guanine chemistry, Nitric Oxide chemistry, Peroxynitrous Acid, Tandem Mass Spectrometry
Abstract: Guanine (Gua), among purines, is a preferred oxidation/nitration target because of its low one-electron redox potential. The reactive oxygen/nitrogen species peroxynitrite (ONOO - ), produced in vivo by the reaction between nitric oxide ( • NO) and superoxide radical (O 2 •‒ ), is responsible for several oxidative modifications in biomolecules, including nitration, nitrosation, oxidation, and peroxidation. In particular, the nitration of Gua, although detected, as well as its reaction kinetics have been seldom investigated. Thus, we studied the concentration- and temperature-dependent formation of 8-nitroguanine (8-NitroGua) in phosphate buffer (pH 7.40) using stopped-flow spectrophotometry. Traces showed a biexponential behavior, with best-fit rate constants: k fast = 4.4 s -1 and k slow = 0.41 s -1 (30 °C, 400 μM both Gua and ONOO - ). k fast increased linearly with the concentration of both reactants whereas k slow was concentration-independent. Linear regression analysis of k fast as a function of Gua and ONOO - M 3 M -1 s -1 and 1.5-3.5 s -1 for the second-order (slope) and first-order (ordinate) rate constants, respectively (30 °C). Since ONOO - is a short-lived species, its decay kinetics was also taken into account for this analysis. The 8-NitroGua product was stable for at least 4 h, so no spontaneous denitration was observed. Stopped-flow assays using antioxidants and free-radical scavengers suggested a mixed direct/indirect reaction mechanism for 8-NitroGua formation. Gua nitration by ONOO - was also observed in the presence of physiologically relevant CO 2 concentrations. The reaction product identity, its yield (∼4.2%, with 400 μM ONOO - and 200 μM Gua), and the reaction mechanism were unequivocally determined by HPLC-MS/MS experiments. In conclusion, 8-NitroGua production at physiologic pH reached significant levels in a few hundred milliseconds, suggesting that the process might be kinetically relevant in vivo and can likely cause permanent nitrative damage to DNA bases., Competing Interests: Declaration of competing interest None., (Copyright © 2022 Elsevier Inc. All rights reserved.)
Published: 2022
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38. The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration.

Author: Mastrogiovanni M, Vargas P, Rose T, Cuche C, Esposito E, Juzans M, Laude H, Schneider A, Bernard M, Goyard S, Renaudat C, Ungeheuer MN, Delon J, Alcover A, and Di Bartolo V
Subjects: Cell Movement, Humans, Mutation, Phenotype, Adenomatous Polyposis Coli genetics, Adenomatous Polyposis Coli Protein genetics
Abstract: Adenomatous polyposis coli (APC) is a tumor suppressor whose mutations underlie familial adenomatous polyposis (FAP) and colorectal cancer. Although its role in intestinal epithelial cells is well characterized, APC importance in T cell biology is ill defined. APC regulates cytoskeleton organization, cell polarity, and migration in various cell types. Here, we address whether APC plays a role in T lymphocyte migration. Using a series of cell biology tools, we unveiled that T cells from FAP patients carrying APC mutations display impaired adhesion and motility in constrained environments. We further dissected the cellular mechanisms underpinning these defects in APC-depleted CEM T cell line that recapitulate the phenotype observed in FAP T cells. We found that APC affects T cell motility by modulating integrin-dependent adhesion and cytoskeleton reorganization. Hence, APC mutations in FAP patients not only drive intestinal neoplasms but also impair T cell migration, potentially contributing to inefficient antitumor immunity.
Published: 2022
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39. Cell polarity regulators, multifunctional organizers of lymphocyte activation and function.

Author: Mastrogiovanni M, Di Bartolo V, and Alcover A
Subjects: Cell Movement, Cytoskeleton metabolism, Humans, T-Lymphocytes, Cell Polarity, Lymphocyte Activation
Abstract: Cell polarity regulators are ubiquitous, evolutionary conserved multifunctional proteins. They contain a variety of protein-protein interaction domains endowing them the capacity to interact with cytoskeleton structures, membrane components and multiple regulatory proteins. In this way, they act in complexes and are pivotal for cell growth and differentiation, tissue formation, stability and turnover, cell migration, wound healing, and others. Hence some of these proteins are tumor suppressors. These cellular processes rely on the establishment of cell polarity characterized by the asymmetric localization of proteins, RNAs, membrane domains, or organelles that together condition cell shape and function. Whether apparently stable, as in epithelia or neurons, or very dynamic, as in immune cells, cell polarity is an active process. It involves cytoskeleton reorganization and targeted intracellular traffic, and results in cellular events such as protein synthesis, secretion and assembly taking place at defined cell poles. Multiple polarity regulators orchestrate these processes. Immune cells are particularly versatile in rapidly polarizing and assuming different shapes, so to swiftly adopt specialized behaviors and functions. Polarity regulators act in various ways in different immune cell types and at their distinct differentiation states. Here we review how cell polarity regulators control different processes and functions along T lymphocyte physiology, including cell migration through different tissues, immunological synapse formation and effector functions., Competing Interests: Conflicts of interest Authors declare that they have no competing interests., (Copyright © 2021 Chang Gung University. Published by Elsevier B.V. All rights reserved.)
Published: 2022
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40. HPLC-MS/MS Oxylipin Analysis of Plasma from Amyotrophic Lateral Sclerosis Patients.

Author: Mastrogiovanni M, Trostchansky A, Naya H, Dominguez R, Marco C, Povedano M, López-Vales R, and Rubbo H
Abstract: Oxylipins play a critical role in regulating the onset and resolution phase of inflammation. Despite inflammation is a pathological hallmark in amyotrophic lateral sclerosis (ALS), the plasma oxylipin profile of ALS patients has not been assessed yet. Herein, we develop an oxylipin profile-targeted analysis of plasma from 74 ALS patients and controls. We found a significant decrease in linoleic acid-derived oxylipins in ALS patients, including 9-hydroxy-octadecadienoic acid (9-HODE) and 13-HODE. These derivatives have been reported as important regulators of inflammation on different cell systems. In addition, some 5-lipoxygenase metabolites, such as 5-hydroxy- eicosatetraenoic acid also showed a significant decrease in ALS plasma samples. Isoprostanes of the F2α family were detected only in ALS patients but not in control samples, while the hydroxylated metabolite 11-HETE significantly decreased. Despite our effort to analyze specialized pro-resolving mediators, they were not detected in plasma samples. However, we found the levels of 14-hydroxy-docosahexaenoic acid, a marker pathway of the Maresin biosynthesis, were also reduced in ALS patients, suggesting a defective activation in the resolution programs of inflammation in ALS. We further analyze oxylipin concentration levels in plasma from ALS patients to detect correlations between these metabolites and some clinical parameters. Interestingly, we found that plasmatic levels of 13-HODE and 9-HODE positively correlate with disease duration, expressed as days since onset. In summary, we developed a method to analyze "(oxy)lipidomics" in ALS human plasma and found new profiles of metabolites and novel lipid derivatives with unknown biological activities as potential footprints of disease onset.
Published: 2022
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41. Spatial Stability of Functional Networks: A Measure to Assess the Robustness of Graph-Theoretical Metrics to Spatial Errors Related to Brain Parcellation.

Author: Bottino F, Lucignani M, Pasquini L, Mastrogiovanni M, Gazzellini S, Ritrovato M, Longo D, Figà-Talamanca L, Rossi Espagnet MC, and Napolitano A
Abstract: There is growing interest in studying human brain connectivity and in modelling the brain functional structure as a network. Brain network creation requires parcellation of the cerebral cortex to define nodes. Parcellation might be affected by possible errors due to inter- and intra-subject variability as a consequence of brain structural and physiological characteristics and shape variations related to ageing and diseases, acquisition noise, and misregistration. These errors could induce a knock-on effect on network measure variability. The aim of this study was to investigate spatial stability, a measure of functional connectivity variations induced by parcellation errors. We simulated parcellation variability with random small spatial changes and evaluated its effects on twenty-seven graph-theoretical measures. The study included subjects from three public online datasets. Two brain parcellations were performed using FreeSurfer with geometric atlases. Starting from these, 100 new parcellations were created by increasing the area of 30% of parcels, reducing the area of neighbour parcels, with a rearrangement of vertices. fMRI data were filtered with linear regression, CompCor, and motion correction. Adjacency matrices were constructed with 0.1, 0.2, 0.3, and 0.4 thresholds. Differences in spatial stability between datasets, atlases, and threshold were evaluated. The higher spatial stability resulted for Characteristic-path-length, Density, Transitivity, and Closeness-centrality, and the lower spatial stability resulted for Bonacich and Katz. Multivariate analysis showed a significant effect of atlas, datasets, and thresholds. Katz and Bonacich centrality, which was subject to larger variations, can be considered an unconventional graph measure, poorly implemented in the clinical field and not yet investigated for reliability assessment. Spatial stability (SS) is affected by threshold, and it decreases with increasing threshold for several measures. Moreover, SS seems to depend on atlas choice and scanning parameters. Our study highlights the importance of paying close attention to possible parcellation-related spatial errors, which may affect the reliability of functional connectivity measures., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Bottino, Lucignani, Pasquini, Mastrogiovanni, Gazzellini, Ritrovato, Longo, Figà-Talamanca, Rossi Espagnet and Napolitano.)
Published: 2022
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42. Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis.

Author: Sánchez-Fernández A, Zandee S, Mastrogiovanni M, Charabati M, Rubbo H, Prat A, and López-Vales R
Subjects: Animals, Anti-Inflammatory Agents pharmacology, Humans, Inflammation metabolism, Leukocytes, Mononuclear metabolism, Mice, Mice, Inbred C57BL, Spinal Cord pathology, Encephalomyelitis, Autoimmune, Experimental metabolism
Abstract: Background: Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiological response is coordinated by endogenous bioactive lipids known as specialized pro-resolving mediators (SPMs). When resolution fails, inflammation becomes uncontrolled leading chronic inflammation and tissue damage, as occurs in multiple sclerosis (MS)., Methods: SPMs and the key biosynthetic enzymes involved in SPM production were analysed by metabololipidomics and qPCR in active brain lesions, serum and peripheral blood mononuclear cells (PBMC) of MS patients as well as in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE). We also tested the therapeutic actions of the SPM coined Maresin-1 (MaR1) in EAE mice and studied its impact on inflammation by doing luminex and flow cytometry analysis., Results: We show that levels of MaR1 and other SPMs were below the limit of detection or not increased in the spinal cord of EAE mice, whereas the production of pro-inflammatory eicosanoids was induced during disease progression. Similarly, we reveal that SPMs were undetected in serum and active brain lesion samples of MS patients, which was linked to impaired expression of the enzymes involved in the biosynthetic pathways of SPMs. We demonstrate that exogenous administration of MaR1 in EAE mice suppressed the protein levels of various pro-inflammatory cytokines and reduced immune cells counts in the spinal cord and blood. MaR1 also decreased the numbers of Th1 cells but increased the accumulation of regulatory T cells and drove macrophage polarization towards an anti-inflammatory phenotype. Importantly, we provide clear evidence that administration of MaR1 in mice with clinical signs of EAE enhanced neurological outcomes and protected from demyelination., Conclusions: This study reveals that there is an imbalance in the production of SPMs in MS patients and in EAE mice, and that increasing the bioavailability of SPMs, such as MaR1, minimizes inflammation and mediates therapeutic actions. Thus, these data suggest that immunoresolvent therapies, such as MaR1, could be a novel avenue for the treatment of MS., (© 2022. The Author(s).)
Published: 2022
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43. Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides.

Author: Ott C, Tomasina F, Campolo N, Bartesaghi S, Mastrogiovanni M, Leyva A, Batthyány C, Meinl W, Grune T, and Radi R
Subjects: Peptides, Proteins, Proteasome Endopeptidase Complex, Tyrosine analogs & derivatives
Abstract: Removal of moderately oxidized proteins is mainly carried out by the proteasome, while highly modified proteins are no longer degradable. However, in the case of proteins modified by nitration of tyrosine residues to 3-nitrotyrosine (NO 2 Y), the role of the proteasome remains to be established. For this purpose, degradation assays and mass spectrometry analyses were performed using isolated proteasome and purified fractions of native cytochrome c (Cyt c) and tyrosine nitrated proteoforms (NO 2 Y74-Cyt c and NO 2 Y97-Cyt c). While Cyt c treated under mild conditions with hydrogen peroxide was preferentially degraded by the proteasome, NO 2 Y74- and NO 2 Y97-Cyt c species did not show an increased degradation rate with respect to native Cyt c. Peptide mapping analysis confirmed a decreased chymotrypsin-like cleavage at C-terminal of NO 2 Y sites within the protein, with respect to unmodified Y residues. Additionally, studies with the proteasome substrate suc-LLVY-AMC (Y-AMC) and its NO 2 Y-containing analog, suc-LLVNO 2 Y-AMC (NO 2 Y-AMC) were performed, both using isolated 20S-proteasome and astrocytoma cell lysates as the proteasomal source. Comparisons of both substrates showed a significantly decreased proteasome activity towards NO 2 Y-AMC. Moreover, NO 2 Y-AMC, but not Y-AMC degradation rates, were largely diminished by increasing the reaction pH, suggesting an inhibitory influence of the additional negative charge contained in NO 2 Y-AMC secondary to nitration. The mechanism of slowing of proteasome activity in NO 2 Y-contaning peptides was further substantiated in studies using the phenylalanine and nitro-phenylalanine peptide analog substrates. Finally, degradation rates of Y-AMC and NO 2 Y-AMC with proteinase K were the same, demonstrating the selective inability of the proteasome to readily cleave at nitrotyrosine sites. Altogether, data indicate that the proteasome has a decreased capability to cleave at C-terminal of NO 2 Y residues in proteins with respect to the unmodified residues, making this a possible factor that decreases the turnover of oxidized proteins, if they are not unfolded, and facilitating the accumulation of nitrated proteins., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
Published: 2021
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44. Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease.

Author: Sánchez-Calvo B, Cassina A, Mastrogiovanni M, Santos M, Trias E, Kelley EE, Rubbo H, and Trostchansky A
Subjects: Animals, Body Composition, Body Weight, Dietary Supplements, Female, Gene Expression Regulation, Enzymologic drug effects, Heme Oxygenase-1 genetics, Heme Oxygenase-1 metabolism, Liver drug effects, Liver pathology, Membrane Proteins genetics, Membrane Proteins metabolism, Mice, Mice, Inbred C57BL, Olive Oil, Organ Size, Fatty Acids chemistry, Fatty Acids pharmacology, Mitochondria drug effects, Non-alcoholic Fatty Liver Disease chemically induced
Abstract: Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive liver fat deposition in the absence of significant alcohol intake. Since extra virgin olive oil (EVOO) reduces fat accumulation, we analyzed the involvement of nitro-fatty acids (NO 2 -FA) on the beneficial effects of EVOO consumption on NAFLD. Nitro-fatty acids formation was observed during digestion in mice supplemented with EVOO and nitrite. Mice fed with a high-fat diet (HF) presented lower plasma NO 2 -FA levels than normal chow, and circulating concentrations recovered when the HF diet was supplemented with 10% EVOO plus nitrite. Under NO 2 -FA formation conditions, liver hemoxygenase-1 expression significantly increased while decreased body weight and fat liver accumulation. Mitochondrial dysfunction plays a central role in the pathogenesis of NAFLD while NO 2 -FA has been shown to protect from mitochondrial oxidative damage. Accordingly, an improvement of respiratory indexes was observed when mice were supplemented with both EVOO plus nitrite. Liver mitochondrial complexes II and V activities were greater in mice with EVOO supplementation and further improved in the presence of nitrite. Overall, our results strongly suggest a positive correlation between NO 2 -OA formation from EVOO and the observed improvement of mitochondrial function in NAFLD. The formation of NO 2 -FA can account for the health benefits associated with EVOO consumption., (Copyright © 2021. Published by Elsevier Inc.)
Published: 2021
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45. Antiplatelet activity and chemical analysis of leaf and fruit extracts from Aristotelia chilensis.

Author: Rodríguez L, Trostchansky A, Wood I, Mastrogiovanni M, Vogel H, González B, Maróstica Junior M, Fuentes E, and Palomo I
Subjects: Anthocyanins chemistry, Anthocyanins isolation & purification, Chile, Chromatography, High Pressure Liquid, Domestication, Fruit chemistry, Humans, P-Selectin metabolism, Plant Extracts chemistry, Plant Extracts pharmacology, Plant Leaves chemistry, Platelet Aggregation Inhibitors chemistry, Platelet Aggregation Inhibitors isolation & purification, Polyphenols chemistry, Polyphenols isolation & purification, Tandem Mass Spectrometry, Tetraspanin 30 metabolism, Anthocyanins pharmacology, Elaeocarpaceae chemistry, Platelet Aggregation Inhibitors pharmacology, Polyphenols pharmacology
Abstract: Aristotelia chilensis (Mol.) Stuntz, also known as maqui, is a plant native to Chile without chemical characterization and quantification of the bioactive compounds present in it. HPLC-UV and HPLC-MS/MS studies have shown the presence, at different concentrations, of phenolic and anthocyanin compounds in fruit and leave extracts of the domesticated maqui clones Luna Nueva, Morena, and Perla Negra. The extracts from leaves and unripe fruits of Luna Nueva and Morena clones significantly inhibit platelet aggregation induced by several agonists; the extracts inhibit platelet granule secretion by decreasing the exposure of P-selectin and CD63 at the platelet membrane. Reactive oxygen species formation in platelets is lower in the presence of maqui extracts. Statistical Pearson analysis supports the levels of phenolic and anthocyanin compounds being responsible for the antiaggregant maqui effects. This work is the first evidence of antiplatelet activity from Aristotelia chilensis giving added value to the use of leaves and unripe fruits from this species., Competing Interests: The authors declare no conflicts of interest.
Published: 2021
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46. Acidity and nucleophilic reactivity of glutathione persulfide.

Author: Benchoam D, Semelak JA, Cuevasanta E, Mastrogiovanni M, Grassano JS, Ferrer-Sueta G, Zeida A, Trujillo M, Möller MN, Estrin DA, and Alvarez B
Subjects: Chromatography, High Pressure Liquid, Chromatography, Reverse-Phase, Disulfides analysis, Disulfides metabolism, Glutathione analysis, Glutathione chemistry, Glutathione metabolism, Hydrogen Peroxide chemistry, Hydrogen Sulfide chemistry, Hydrogen Sulfide metabolism, Hydrogen-Ion Concentration, Kinetics, Peroxynitrous Acid chemistry, Quantum Theory, Tandem Mass Spectrometry, Thermodynamics, Disulfides chemistry, Glutathione analogs & derivatives
Abstract: Persulfides (RSSH/RSS - ) participate in sulfur trafficking and metabolic processes, and are proposed to mediate the signaling effects of hydrogen sulfide (H 2 S). Despite their growing relevance, their chemical properties are poorly understood. Herein, we studied experimentally and computationally the formation, acidity, and nucleophilicity of glutathione persulfide (GSSH/GSS - ), the derivative of the abundant cellular thiol glutathione (GSH). We characterized the kinetics and equilibrium of GSSH formation from glutathione disulfide and H 2 S. A p K a of 5.45 for GSSH was determined, which is 3.49 units below that of GSH. The reactions of GSSH with the physiologically relevant electrophiles peroxynitrite and hydrogen peroxide, and with the probe monobromobimane, were studied and compared with those of thiols. These reactions occurred through S N 2 mechanisms. At neutral pH, GSSH reacted faster than GSH because of increased availability of the anion and, depending on the electrophile, increased reactivity. In addition, GSS - presented higher nucleophilicity with respect to a thiolate with similar basicity. This can be interpreted in terms of the so-called α effect, i.e. the increased reactivity of a nucleophile when the atom adjacent to the nucleophilic atom has high electron density. The magnitude of the α effect correlated with the Brønsted nucleophilic factor, β nuc , for the reactions with thiolates and with the ability of the leaving group. Our study constitutes the first determination of the p K a of a biological persulfide and the first examination of the α effect in sulfur nucleophiles, and sheds light on the chemical basis of the biological properties of persulfides., Competing Interests: Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article., (© 2020 Benchoam et al.)
Published: 2020
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47. Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions.

Author: Mastrogiovanni M, Juzans M, Alcover A, and Di Bartolo V
Abstract: Dynamic localization of receptors and signaling molecules at the plasma membrane and within intracellular vesicular compartments is crucial for T lymphocyte sensing environmental cues, triggering membrane receptors, recruiting signaling molecules, and fine-tuning of intracellular signals. The orchestrated action of actin and microtubule cytoskeleton and intracellular vesicle traffic plays a key role in all these events that together ensure important steps in T cell physiology. These include extravasation and migration through lymphoid and peripheral tissues, T cell interactions with antigen-presenting cells, T cell receptor (TCR) triggering by cognate antigen-major histocompatibility complex (MHC) complexes, immunological synapse formation, cell activation, and effector functions. Cytoskeletal and vesicle traffic dynamics and their interplay are coordinated by a variety of regulatory molecules. Among them, polarity regulators and membrane-cytoskeleton linkers are master controllers of this interplay. Here, we review the various ways the T cell plasma membrane, receptors, and their signaling machinery interplay with the actin and microtubule cytoskeleton and with intracellular vesicular compartments. We highlight the importance of this fine-tuned crosstalk in three key stages of T cell biology involving cell polarization: T cell migration in response to chemokines, immunological synapse formation in response to antigen cues, and effector functions. Finally, we discuss two examples of perturbation of this interplay in pathological settings, such as HIV-1 infection and mutation of the polarity regulator and tumor suppressor adenomatous polyposis coli (Apc) that leads to familial polyposis and colorectal cancer., (Copyright © 2020 Mastrogiovanni, Juzans, Alcover and Di Bartolo.)
Published: 2020
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48. Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.

Author: Juzans M, Cuche C, Rose T, Mastrogiovanni M, Bochet P, Di Bartolo V, and Alcover A
Subjects: Adenomatous Polyposis Coli metabolism, Adenomatous Polyposis Coli pathology, Adenomatous Polyposis Coli Protein immunology, Animals, Cell Differentiation, Cell Line, Tumor, Cytoskeleton metabolism, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microtubules ultrastructure, Mutation, NFATC Transcription Factors immunology, Signal Transduction, T-Lymphocytes, Regulatory immunology, T-Lymphocytes, Regulatory pathology, Actins metabolism, Adenomatous Polyposis Coli genetics, Adenomatous Polyposis Coli Protein genetics, Immunological Synapses metabolism, Microtubules immunology, NFATC Transcription Factors genetics
Abstract: Adenomatous polyposis coli (Apc) is a cell polarity regulator and a tumor suppressor associated with familial adenomatous polyposis and colorectal cancer. Apc involvement in T lymphocyte functions and antitumor immunity remains poorly understood. Investigating Apc-depleted human CD8 T cells and CD8 T cells from Apc Min/+ mutant mice, we found that Apc regulates actin and microtubule cytoskeleton remodeling at the immunological synapse, controlling synapse morphology and stability and lytic granule dynamics, including targeting and fusion at the synapse. Ultimately, Apc tunes cytotoxic T cell activity, leading to tumor cell killing. Furthermore, Apc modulates early TCR signaling and nuclear translocation of the NFAT transcription factor with mild consequences on the expression of some differentiation markers. In contrast, no differences in the production of effector cytokines were observed. These results, together with our previous findings on Apc function in regulatory T cells, indicate that Apc mutations may cause a dual damage, first unbalancing epithelial cell differentiation and growth driving epithelial neoplasms and, second, impairing T cell-mediated antitumor immunity at several levels., (Copyright © 2020 The Authors.)
Published: 2020
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49. Fatty acid nitration in human low-density lipoprotein.

Author: Mastrogiovanni M, Trostchansky A, and Rubbo H
Subjects: Humans, Nitric Oxide metabolism, Oxidation-Reduction, Fatty Acids metabolism, Lipoproteins, LDL metabolism
Abstract: Lipid nitration occurs during physiological and pathophysiological conditions, generating a variety of biomolecules capable to modulate inflammatory cell responses. Low-density lipoprotein (LDL) oxidation has been extensively related to atherosclerotic lesion development while oxidative modifications confer the particle pro-atherogenic features. Herein, we reviewed the oxidation versus nitration of human LDL protein and lipid fractions. We propose that unsaturated fatty acids present in LDL can be nitrated under mild nitration conditions, suggesting an anti-atherogenic role for LDL carrying nitro-fatty acids (NFA)., (Copyright © 2019 Elsevier Inc. All rights reserved.)
Published: 2020
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50. Data of detection and characterization of nitrated conjugated-linoleic acid (NO 2 -cLA) in LDL.

Author: Mastrogiovanni M, Trostchansky A, and Rubbo H
Abstract: Under physiological and pathophysiological conditions, lipid nitration occurs generating nitro-fatty acids (NFA) with pleiotropic activities as modulation of inflammatory cell responses. Foam cell formation and atherosclerotic lesion development have been extensively related to low-density lipoprotein (LDL) oxidation. Considering our manuscript "Fatty acid nitration in human low-density lipoprotein" (https://doi.org/10.1016/j.abb.2019.108190), herein we report the oxidation versus nitration of human LDL protein and lipid fractions. Data is shown on LDL fatty acid nitration, in particular, formation and quantitation of nitro-conjugated linoleic acid (NO 2 -cLA) under mild nitration conditions. In parallel to NO 2 -cLA formation, depletion of endogenous antioxidants, protein tyrosine nitration, and carbonyl formation is observed. Overall, our data propose the formation of a potential anti-atherogenic form of LDL carrying NFA., (© 2019 The Author(s).)
Published: 2019
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