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1. Negative curvature in locally reducible Artin groups

Author

Mastrocola, Jill

Subjects
Mathematics - Group Theory
Abstract

In this paper, we define the 2-complete Artin complex and show that it is systolic for locally reducible Artin groups. The stabilizers of simplices in this complex are exactly the proper parabolic subgroups which are "2-complete." We use this systolicity to show that parabolic subgroups, with 2-completions that are not the whole Artin group, are weakly malnormal. This allows us to conclude that many locally reducible Artin groups are acylindrically hyperbolic.

Published
2024

2. Preclinical immunogenicity and safety of hemagglutinin-encoding modRNA influenza vaccines

Author

Teresa Hauguel, Amy Sharma, Emily Mastrocola, Susan Lowry, Mohan S. Maddur, Cheng Hui Hu, Swati Rajput, Allison Vitsky, Shambhunath Choudhary, Balasubramanian Manickam, Ivna De Souza, Yana Chervona, Raquel Munoz Moreno, Charisse Abdon, Larissa Falcao, Kristin Tompkins, Deanne Illenberger, Rachel Smith, Fanyu Meng, Shuai Shi, Kari Sweeney Efferen, Victoria Markiewicz, Cinthia Umemoto, Jianfang Hu, Wei Chen, Ingrid Scully, Cynthia M. Rohde, Annaliesa S. Anderson, and Pirada Suphaphiphat Allen

Subjects
Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Seasonal epidemics of influenza viruses are responsible for a significant global public health burden. Vaccination remains the most effective way to prevent infection; however, due to the persistence of antigenic drift, vaccines must be updated annually. The selection of vaccine strains occurs months in advance of the influenza season to allow adequate time for production in eggs. RNA vaccines offer the potential to accelerate production and improve efficacy of influenza vaccines. We leveraged the nucleoside-modified RNA (modRNA) platform technology and lipid nanoparticle formulation process of the COVID-19 mRNA vaccine (BNT162b2; Comirnaty®) to create modRNA vaccines encoding hemagglutinin (HA) (modRNA-HA) for seasonal human influenza strains and evaluated their preclinical immunogenicity and toxicity. In mice, a monovalent modRNA vaccine encoding an H1 HA demonstrated robust antibody responses, HA-specific Th1-type CD4+ T cell responses, and HA-specific CD8+ T cell responses. In rhesus and cynomolgus macaques, the vaccine exhibited durable functional antibody responses and HA-specific IFN-γ+ CD4+ T cell responses. Immunization of mice with monovalent, trivalent, and quadrivalent modRNA-HA vaccines generated functional antibody responses targeting the seasonal influenza virus(es) encoded in the vaccines that were greater than, or similar to, those of a licensed quadrivalent influenza vaccine. Monovalent and quadrivalent modRNA-HA vaccines were well-tolerated by Wistar Han rats, with no evidence of systemic toxicity. These nonclinical immunogenicity and safety data support further evaluation of the modRNA-HA vaccines in clinical studies.

Published
2024
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3. Preclinical immunogenicity and safety of hemagglutinin-encoding modRNA influenza vaccines

Author

Hauguel, Teresa, Sharma, Amy, Mastrocola, Emily, Lowry, Susan, Maddur, Mohan S., Hu, Cheng Hui, Rajput, Swati, Vitsky, Allison, Choudhary, Shambhunath, Manickam, Balasubramanian, De Souza, Ivna, Chervona, Yana, Moreno, Raquel Munoz, Abdon, Charisse, Falcao, Larissa, Tompkins, Kristin, Illenberger, Deanne, Smith, Rachel, Meng, Fanyu, Shi, Shuai, Efferen, Kari Sweeney, Markiewicz, Victoria, Umemoto, Cinthia, Hu, Jianfang, Chen, Wei, Scully, Ingrid, Rohde, Cynthia M., Anderson, Annaliesa S., and Suphaphiphat Allen, Pirada

Published
2024
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5. Influencia de las condiciones ambientales y tiempo de fermentación aerobia sobre la calidad del café (Coffea arabica L.) var. Catucaí

Author

Brayan Alexander Álvarez López, Nicola Antonio Mastrocola Racines, Edgar Gabriel Tello Hidalgo, and Duilio Gilberto Torres Rodríguez

Subjects
acidez, beneficio, catación, temperatura, pH, Agriculture (General), S1-972, Animal culture, SF1-1100, Cattle, SF191-275
Abstract

Durante el proceso de fermentación, las levaduras y las bacterias descomponen los azúcares que dan al café su sabor único. Por lo tanto, el propósito de este estudio fue determinar si el tiempo de fermentación aeróbica en dos condiciones ambientales, específicamente en granos de café despulpados de la variedad Catucaí (Coffea arabica L.), tiene un efecto sobre la calidad del café en taza. Para ello se estudiaron variables como el pH del medio de fermentación, así como el resultado obtenido en las catas de bebidas. Los principales resultados muestran que la temperatura ambiente afecta las condiciones de fermentación cuando llega los 18,3 °C, provocando una disminución del pH y por ende de la fermentación láctica. Al analizar los puntajes de fusión, se encontró que el tiempo óptimo de fermentación se logró a las 16 horas en ambiente de invernadero con un valor de 79,25, el cual se considera "bueno" según los estándares de la Asociación de Cafés Especiales. A pesar de estos tratamientos, la variedad no logró obtener un resultado satisfactorio como consecuencia de un inadecuado manejo nutricional y fitosanitarios del cultivo, que disminuyeron la calidad de la bebida de café, con puntajes inferiores a los 80 puntos.

Published
2024
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6. Bioecology and sport: linking theory and practice

Author

Regina Brandão, Daniela Lopes Angelo, Ana Paula Mastrocola, Mateus Fabrício Pallone Manzini, Bruno Hupfer, Marcelo Villas Boas Junior, Mario Reyes-Bossio, and Verónica Tutte Vallarino

Subjects
PPCT model, Bronfenbrenner, sport, elite athlete, interventions, Primary Physical Education, Social Sciences
Abstract

Despite considerable research efforts to refine and apply the PPCT model in sports settings, there remains a lack of guidance on its practical implementation, both in research and elite athlete practice. This paper aims to propose a methodology for operationalizing the theory specifically tailored to elite sports. This involves (a) elucidating the operationalization of the Process, Person, Context, and Time components within the PPCT framework; (b) exploring the utilization of the PPCT model in sports contexts, integrating empirical research findings; and (c) presenting recommendations for designing and executing elite athlete-centered interventions and development programs. These athlete-centered initiatives have the potential to effectively address athletes’ needs and enhance their performance levels. Recognizing the significance of customizing interventions to individual athlete attributes, fostering positive relationships, addressing environmental influences, and acknowledging transitional stages is crucial for maximizing athletes’ well-being, performance, and overall success. By examining the four key components of the bioecological model – including contextual aspects of sport (microsystem, mesosystem, exosystem, macrosystem), athlete attributes (dispositions, resources, demands), the context-athlete relationship dynamics, and the temporal dimension (chronosystem) to understand how temporal changes impact athletes’ trajectories – this paper intentions to advance understanding of the bioecological factors shaping elite athletes’ experiences. Psychological interventions targeting individual-environment congruence for elite athletes carry significant implications. These interventions should be intricately personalized to meet the distinctive needs and characteristics of each athlete, contributing to more effective and tailored support within elite sports environments.

Published
2024
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7. Long Acting Reversible Contraception After Surgical Abortion With High Rate of Continuation and Patients’ Satisfaction

Author

Paola Algeri, Laura Imbruglia, Laura Colonna, Vanda Savoldi, Nunzia Mastrocola, and Silvia von Wunster

Subjects
Abortion, Contraception, Long-Acting Reversible Contraception, Gynecology and obstetrics, RG1-991
Abstract

Objective: In Italy the percentage of repeated abortions is about 24%. Long-acting reversible contraceptive (LARC) methods are currently considered the most effective mode worldwide and are associated with the highest rate of 12-months continuation, with a potential reported reduction of recurrent abortions. The aim of this study was evaluating LARC continuation and the patients’ satisfaction at two and twelve months in use. Materials and methods: A longitudinal observational study collected women who underwent surgical abortion and placed a LARC method at the time of abortion in our hospital. Results: Totally 828 women underwent surgical abortion during the study period from which 434 choose a LARC method. After two months the rate of continuation of 52mg LNG IUD was 100% in women presenting for follow-up. Continuation rate at one year was approximately 70% for all LARC methods. More than 70% of women declared themselves satisfied or very satisfied with all LARC methods. Conclusion: Despite a high rate of patient loss at follow-up, LARC methods showed a high rate of continuation at two and twelve months, with a high degree of patients' satisfaction.

Published
2024
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8. Diretriz Brasileira de Ergometria em População Adulta – 2024

Author

Tales de Carvalho, Odilon Gariglio Alvarenga de Freitas, William Azem Chalela, Carlos Alberto Cordeiro Hossri, Mauricio Milani, Susimeire Buglia, Dalton Bertolim Precoma, Andréa Maria Gomes Marinho Falcão, Luiz Eduardo Mastrocola, Iran Castro, Pedro Ferreira de Albuquerque, Ricardo Quental Coutinho, Fabio Sandoli de Brito, Josmar de Castro Alves, Salvador Manoel Serra, Mauro Augusto dos Santos, Clea Simone Sabino de Souza Colombo, Ricardo Stein, Artur Haddad Herdy, Anderson Donelli da Silveira, Claudia Lucia Barros de Castro, Miguel Morita Fernandes da Silva, Romeu Sergio Meneghello, Luiz Eduardo Fonteles Ritt, Felipe Lopes Malafaia, Leonardo Filipe Benedeti Marinucci, José Luiz Barros Pena, Antônio Eduardo Monteiro de Almeida, Marcelo Luiz Campos Vieira, and Arnaldo Laffitte Stier Júnior

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2024
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9. Could the contraceptive counselling improve contraceptive choice after abortion? A multicentric study to evaluate patients’ perception

Author

von Wunster, Silvia, Algeri, Paola, Scassellati, Giovanna, Agatone, Silvana, Spazzini, Donata, Peppi, Giangavino, Cicchitti, Annamaria, Di Leo, Salvatore, Ermio, Carmelina, Pati, Mariangela, Mastrocola, Nunzia, Granata, Daniela, Silvestri, Maurizio, Pinton, Romina, Giambanco, Laura, Grandi, Stefano, Molinari, Maria Antonietta, Imbruglia, Laura, Chiantera, Antonio, Trojano, Vito, Viora, Elsa, Stigliano, Carlo Maria, and Parazzini, Fabio

Published
2024
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11. Sensory Evaluation and Consumers’ Acceptance of a Low Glycemic and Gluten-Free Carob-Based Bakery Product

Author

Luigi Esposito, Nicola Casolani, Marco Ruggeri, Umile Gianfranco Spizzirri, Francesca Aiello, Emilio Chiodo, Maria Martuscelli, Donatella Restuccia, and Dino Mastrocola

Subjects
food choice, gluten-free, carob, consumer acceptance, glycemic index, Chemical technology, TP1-1185
Abstract

Carob pulp flour has antidiabetic and antioxidant activities, is naturally sweet, and is rich in fibers. It is obtained from carob pod pulp from the evergreen tree Ceratonia siliqua L., which is grown in Mediterranean areas and is known for locust bean gum production. Despite its valuable effects on health, such as the modulation of the glycemic index, this ingredient has a tremendous impact on technological and hedonic features, mainly on color, flavor, and texture. In this paper, the qualitative features and consumers’ acceptance of a carob-based gluten-free bakery product where rice flour was substituted at 40% with carob pulp flour were studied. A panel group of experts described the bread as dark, quite dense, sweet, aromatic, and with a limited bubble dispersion. On the other hand, the sensory assessment and the willingness to pay of consumers were assessed in two groups (a fully informed one about heathy attributes of the food and a blind one). The results indicated a moderate appreciation of the overall quality of the product (average score between 4 and 5 points on a 9-point Likert scale). The information about the food’s healthy properties and the ability to maintain a low glycemic index did not enhance the consumers’ perception of the product, while previous knowledge and involvement in the product consumption were perceived to have primary importance regarding the final consumers’ choice. Finally, an accelerated shelf-life test was run on the packaged snack to evaluate the general quality and stability. The protective packaging helped in limiting bread decay and maintaining the textural characteristics.

Published
2024
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13. Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and myocardial ischemia responses of patients with HFpEF or HFmrEF

Author

C.A.C. Hossri, F.C. Araujo, B.G. Baldi, R. Otterstetter, V.R. Uemoto, C.R.R. Carvalho, L.E. Mastrocola, and A.L.P. Albuquerque

Subjects
Cardiopulmonary rehabilitation, Exercise test, Ischemic heart disease, Arrhythmia, SF-36 quality of life, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

There's limited evidence of the potential benefits of cardiopulmonary and metabolic rehabilitation (CPMR) in patients with heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) and coronary artery disease (CAD). The aim of this study was to investigate the impact of CPMR on the myocardial ischemia response (MIR), exercise-induced arrhythmias (EIA), New York Heart Association (NYHA) functional class, heart rate recovery (HRR), Borg CR10 perceived symptoms, and the SF-36 physical and mental health summary scores. A prospective cohort study was conducted with 106 patients undergoing 12 weeks of CPMR who completed two exercise tests pre- and post-CPMR: 1) maximum incremental test (CPX) and 2) submaximal constant load test (SUB). After CPMR, the effects on MIR, EIA, NYHA functional class, and HRR during both tests were analyzed. There was a significant change in NYHA functional classes after CPMR, with 96% of the patients in class I (vs 62% pre-CPMR, P

Published
2024
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17. A Survey on Potentially Beneficial and Hazardous Bioactive Compounds in Cocoa Powder Samples Sourced from the European Market

Author

Luigi Esposito, Matteo Perillo, Carla Daniela Di Mattia, Annalisa Scroccarello, Flavio Della Pelle, Dario Compagnone, Giampiero Sacchetti, Dino Mastrocola, and Maria Martuscelli

Subjects
biogenic amines, polyphenols, salsolinol, organic processing, raw cocoa, alkalization treatment, Chemical technology, TP1-1185
Abstract

Cocoa (Theobroma cacao, L.) represents an important market that gained relevance and became an esteemed commodity thanks to cocoa powder, chocolate, and other related products. This work analyzed 59 cocoa powder samples from the European market. Three distinct subgroups were identified: organic or conventional, alkalized or not alkalized, and raw or roasted processing. The impact of the technological process on their pH, color, and compositional traits, as well as their content of biogenic amines and salsolinol, was evaluated. The phenolic fraction was also investigated through both common and emerging methods. The results depict that the influence of the agronomical practices (organic/conventional) did not significantly (p < 0.05) affect the composition of the cocoa powders; similarly, the roasting process was not a determinant of the compounds traced. On the other hand, the alkalinization process greatly impacted color and pH, no matter the cocoa’s provenience or obtention or other processes, also resulting in reducing the phenolic fraction of the treated samples. Principal component analysis confirmed that the alkali process acts on pH, color, and phenolic composition but not on the content of other bioactive molecules (biogenic amines and salsolinol). All the samples were safe, while the alkalized powders saw a great reduction in beneficial biocompounds. A novel strategy could be to emphasize on the label whether cocoa powder is non-alkalized to meet the demand for more beneficial products.

Published
2024
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21. Microencapsulation of hop bioactive compounds by spray drying: Role of inlet temperature and wall material

Author

Simona Tatasciore, Veronica Santarelli, Lilia Neri, Carla Daniela Di Mattia, Alessandro Di Michele, Dino Mastrocola, and Paola Pittia

Subjects
Hop extract, Bioactive compounds, Spray-drying microencapsulation, β-cyclodextrin, Gum Arabic, Maltodextrin, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract

This study explores the effect of spray-drying (SD) inlet temperatures (Tinlet 120 and 150 °C) and wall material on the chemical and physico-chemical properties of microencapsulated hop extracts (MHE). Hop extract was formulated with maltodextrin (MD) and gum Arabic (GA) used in single or in combination with β-cyclodextrin (βCD). MHE were evaluated for physical properties, bitter acids (BA), total polyphenol content (TPC) and encapsulation efficiency (TPC EE), and antioxidant capacity (AOC). Powders produced at Tinlet 150 °C exhibited the highest flowability and generally higher TPC yield. Besides Tinlet, MD enabled the obtaining of MHE with the highest encapsulation efficiency. Other physico-chemical and antioxidant properties differently varied depending on the Tinlet. Overall, the βCD addition positively affected α-acids, and β-acids of MHE obtained at Tinlet 120 °C. ATR-FTIR analysis showed hydrogen bond formation between hop compounds and βCD. Multifactorial ANOVA highlighted that Tinlet, W, and their interaction influenced almost all the chemical and physico-chemical properties of MHE.

Published
2024
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22. IDENTIFICANDO PERFIS DE GAMERS NA ESPM

Author

Vicente Martin Mastrocola and Felipe Correa Mello

Subjects
pesquisa quantitativa, Newzoo’s Gamer Segmentation™, perfis de gamers, Visual arts, N1-9211
Abstract

O presente estudo teve como objetivo identificar perfis de gamers na graduação da Escola Superior de Propaganda e Marketing de São Paulo. Tomando como base a pesquisa Gamer Segmentation™, realizada pelo instituto holandês Newzoo, que apresenta nove perfis/personas que compõem o mercado mundial de games na atualidade, aplicamos uma survey online buscando entender – a partir desse estudo – quais os tipos de consumidores de games que são mais proeminentes no ambiente da faculdade ESPM. Como recorte para este projeto, aplicamos um questionário estruturado quantitativo em turmas que cursam disciplinas relacionadas ao universo dos games: Game Essentials (no curso de Sistemas de Informação), Ciclos de Produção 5 – Projeto de Game (no curso de Cinema e Audiovisual) e E-Sports e o Ecossistema Gamer (disciplina eletiva que congrega estudantes de todos os cursos da faculdade ESPM); no intervalo de duas semanas obtivemos 96 questionários respondidos e pudemos compreender alguns aspectos fundamentais de como é o perfil do consumidor de games no âmbito em questão. Indo além, por meio deste estudo, foi possível compreender questões de consumo midiático relacionado aos games, consumo de produtos do universo gamer e que tipos de perfis de jogadores/consumidores de games temos na faculdade. O estudo a seguir, além de mostrar um panorama desta robusta indústria, também sinaliza alguns caminhos de conteúdo que podem ser abordados ou aprimorados nas disciplinas em questão.

Published
2023
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23. Laparoscopic Hysterosacropexy: Is it a Safe Option for Fertility Spearing?

Author

Paola Algeri, Laura Colonna, Silvia Bergamelli, Laura Imbruglia, Nunzia Mastrocola, and Silvia Von Wunster

Subjects
Hysterosacropexy, Laparoscopy, Pelvic Pain, Pregnancy, Prolapse Recurrence Risk, Gynecology and obstetrics, RG1-991
Abstract

Objective: In case of uterine prolapse, hyseroxacropexy, a conservative surgical approach, which allows the sparing of body image and sexuality, could be the choice in fertile women. Few information are reported on subsequent pregnancy after surgery. Case report: A 33 years-old women with symptomatic prolapse underwent a laparoscopic hysterosacropexy. Subsequently she expressed her pregnancy desire and she got pregnant. A scheduled caesarean section was performed without complication. The subsequent follow-up was regular: the patient was asymptomatic and presented no sign of prolapse recurrence. Conclusion: In motivate and well counselled patient, informed about the risk of prolapse recurrence, pregnancy could be considered after hysterosacropexy.

Published
2023
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25. Os Benefícios dos Exercícios Físicos no Câncer de Mama

Author

Milena dos Santos Barros Campos, Roberta Helena Fernandes Feitosa, Carolina Christianini Mizzaci, Maria do Rosário Toscano von Flach, Betty Janny Maia Siqueira, and Luiz Eduardo Mastrocola

Subjects
Neoplasias da mama, Técnicas de Exercício e Movimento, Exercício, Dieta Saudável, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Resumo O câncer de mama é a neoplasia mais prevalente nas mulheres, em torno de 30% de todos os tipos de câncer, enquanto no sexo masculino é responsável por apenas 1% dos casos. No mundo, é a primeira causa de morte por câncer em mulheres. A incidência e a mortalidade variam de acordo com a etnia, região territorial e nível socioeconômico. Em virtude da baixa prevalência do câncer de mama em homens e a escassez de literatura, as condutas são baseadas em extrapolações dos estudos no sexo feminino. As evidências científicas sugerem efeitos benéficos dos exercícios físicos na prevenção, durante o tratamento e no pós-tratamento do câncer de mama. Além do combate ao sedentarismo, é importante manter um peso saudável, limitar o consumo de álcool, e seguir dieta balanceada, rica em frutas, vegetais, grãos e fibras e reduzida em carnes vermelhas. As ações dos exercícios não se restringem ao câncer de mama, mas têm impacto importante no controle dos fatores de risco modificáveis, diminuindo a incidência das doenças cardiovasculares e a mortalidade por causas globais e cardíaca.

Published
2022
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27. Anti-Glycation Properties of Zinc-Enriched Arthrospira platensis (Spirulina) Contribute to Prevention of Metaflammation in a Diet-Induced Obese Mouse Model

Author

Aimaretti, E, Porchietto, E, Mantegazza, G, Gargari, G, Collotta, D, Einaudi, G, Ferreira Alves, G, Marzani, E, Algeri, A, Dal Bello, F, Aragno, M, Cifani, C, Guglielmetti, S, Mastrocola, R, Collino, M, Aimaretti E., Porchietto E., Mantegazza G., Gargari G., Collotta D., Einaudi G., Ferreira Alves G., Marzani E., Algeri A., Dal Bello F., Aragno M., Cifani C., Guglielmetti S., Mastrocola R., Collino M., Aimaretti, E, Porchietto, E, Mantegazza, G, Gargari, G, Collotta, D, Einaudi, G, Ferreira Alves, G, Marzani, E, Algeri, A, Dal Bello, F, Aragno, M, Cifani, C, Guglielmetti, S, Mastrocola, R, Collino, M, Aimaretti E., Porchietto E., Mantegazza G., Gargari G., Collotta D., Einaudi G., Ferreira Alves G., Marzani E., Algeri A., Dal Bello F., Aragno M., Cifani C., Guglielmetti S., Mastrocola R., and Collino M.

Abstract

Advanced glycation end products (AGEs) exert a key pathogenic role in the development of obesity and insulin resistance. Thanks to its abundance in bioactive compounds, the microalga Arthrospira platensis (spirulina, SP) is proposed as a nutritional supplement. Here, we investigated the potential anti-glycating properties of SP enriched with zinc (Zn-SP) and the following impact on diet-induced metabolic derangements. Thirty male C57Bl6 mice were fed a standard diet (SD) or a high-fat high-sugar diet (HFHS) for 12 weeks, and a subgroup of HFHS mice received 350 mg/kg Zn-SP three times a week. A HFHS diet induced obesity and glucose intolerance and increased plasma levels of pro-inflammatory cytokines and transaminases. Zn-SP administration restored glucose homeostasis and reduced hepatic dysfunction and systemic inflammation. In the liver of HFHS mice, a robust accumulation of AGEs was detected, paralleled by increased expression of the main AGE receptor (RAGE) and depletion of glyoxalase-1, whereas Zn-SP administration efficiently prevented these alterations reducing local pro-inflammatory responses. 16S rRNA gene profiling of feces and ileum content revealed altered bacterial community structure in HFHS mice compared to both SD and HFHS + Zn-SP groups. Overall, our study demonstrates relevant anti-glycation properties of Zn-SP which contribute to preventing AGE production and/or stimulate AGE detoxification, leading to the improvement of diet-related dysbiosis and metabolic derangements.

Published
2024

29. Comparison of two different antiseptics regarding intracutaneous microbial load after preoperative skin cleansing in total knee and hip arthroplasties

Author

Sabrina Böhle, Anna-Maria Vogel, Georg Matziolis, Patrick Strube, Sebastian Rohe, Steffen Brodt, Mario Mastrocola, Henk Eijer, Jürgen Rödel, and Chris Lindemann

Subjects
Medicine, Science
Abstract

Abstract Periprosthetic infections (PPIs) are a serious concern in total knee and hip arthroplasty, and they have an increasing incidence. To prevent PPI, preoperative skin disinfection, as a key element of antisepsis, represents an important part of infection prevention. However, no specific antiseptic agent is endorsed by the relevant guidelines. The purpose of this retrospective, not randomized study was to investigate the difference in the residual bacteria load between an approved antiseptic with an alcohol-based solution with additional benzalkonium chloride (BAC) and an alcohol-based solution with additional octenidine dihydrochloride (OCT) at two different time periods. In 200 consecutive patients with total knee or hip arthroplasty, skin samples from the surgical sites were collected after skin disinfection with BAC (100 g solution contain: propan-2-ol 63.0 g, benzalkonium chloride 0.025 g) or OCT (100 g solution contain: octenidine dihydrochloride 0.1 g, propan-1-ol, 30.0 g, propan-2-ol 45.0 g) (100 patients per group). Following the separation of cutis and subcutis and its processing, culture was performed on different agar plates in aerobic and anaerobic environments. In the case of bacteria detection, the microbial identification was determined by matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS), and the number of contaminated samples was compared between the groups. Additionally, multiple regression analysis was performed to examine the effect of the type of disinfectant, BMI, age, sex, rheumatoid arthritis, diabetes mellitus, skin disorders, smoking status, and localization of skin samples on positive bacteria detection. A total of 34 samples were positive for bacteria in the BAC group, while only 17 samples were positive in the OCT group (p = 0.005). Disinfectant type was the only significant parameter in the multiple regression analysis (p = 0.006). A significantly higher contamination rate of the subcutis was shown in the BAC group compared to the OCT group (19 vs. 9, p = 0,003). After the change from BAC to OCT in preoperative skin cleansing in the hip and knee areas, the number of positive cultures decreased by 50%, which might have been caused by a higher microbicidal activity of OCT. Therefore, the use of OCT in preoperative cleansing may reduce the risk of PPI in hip and knee surgery. Randomized controlled trials are required to confirm the effect and to evaluate if it reduces the risk of PPI.

Published
2022
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30. Patients Have Poor Postoperative Recall of Information Provided the Day of Surgery but Report Satisfaction With and High Use of an E-mailed Postoperative Digital Media Package

Author

Kyle Shultz, D.O., Marissa Mastrocola, M.D., Tyler Smith, D.O., and Brian Busconi, M.D.

Subjects
Sports medicine, RC1200-1245
Abstract

Purpose: To understand what portions of the surgical day patients remember, what parts of an e-mailed media package regarding their surgery patients are used, and how that information affects their surgical experience. Methods: Patients undergoing an outpatient arthroscopic procedure were approached in the preoperative area and asked to remember 3 words. Postoperatively, they were seen by the surgeon to discuss surgical findings and instructions. They were then e-mailed a multimedia package containing a thank you letter, postoperative instructions, annotated arthroscopy images, and a personalized video from the surgeon. Patients were called 2 to 5 days after surgery to answer survey questions and recall the 3 words they were told on the day of surgery. Results: Of the 160 patients, 100% received and accessed the e-mail. When asked if they remembered the postoperative conversation, 125 (78.1%) patients responded yes and 35 (21.9%) responded no. When asked to rate how well they remembered the postoperative conversation, 75.2% patients rated their memory very poor (48, 38.4%) or poor (46, 36.8%). Similarly, 129 (80.6%) patients were unable to remember the 3 surgeon-related words. One hundred percent of patients strongly agreed (145, 90.6%) or agreed (15, 9.4%) the e-mail package enhanced their experience. In addition, 100% of patients strongly agreed (150, 93.8%) or agreed (10, 6.2%) the surgeon video enhanced their experience. The average e-mail shares per patient was 2.5, with 158 (98.7%) of patients sharing the e-mail at least once. Conclusions: This study shows that patients had poor memory of in-person conversations on the day of surgery. However, patients were satisfied with a postoperative multimedia package provided via e-mail after surgery. Patients interacted with the e-mail primarily on their cell phones, liked the surgeon video, and shared the e-mail with others. Level of evidence: Level IV, therapeutic case series.

Published
2023
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31. Anti-Glycation Properties of Zinc-Enriched Arthrospira platensis (Spirulina) Contribute to Prevention of Metaflammation in a Diet-Induced Obese Mouse Model

Author

Eleonora Aimaretti, Elisa Porchietto, Giacomo Mantegazza, Giorgio Gargari, Debora Collotta, Giacomo Einaudi, Gustavo Ferreira Alves, Enrica Marzani, Alessandro Algeri, Federica Dal Bello, Manuela Aragno, Carlo Cifani, Simone Guglielmetti, Raffaella Mastrocola, and Massimo Collino

Subjects
advanced glycation end products (AGEs), Arthrospira platensis (spirulina), zinc supplementation, metaflammation, glyoxalase-1 (GLO1), receptor for AGEs (RAGE), Nutrition. Foods and food supply, TX341-641
Abstract

Advanced glycation end products (AGEs) exert a key pathogenic role in the development of obesity and insulin resistance. Thanks to its abundance in bioactive compounds, the microalga Arthrospira platensis (spirulina, SP) is proposed as a nutritional supplement. Here, we investigated the potential anti-glycating properties of SP enriched with zinc (Zn-SP) and the following impact on diet-induced metabolic derangements. Thirty male C57Bl6 mice were fed a standard diet (SD) or a high-fat high-sugar diet (HFHS) for 12 weeks, and a subgroup of HFHS mice received 350 mg/kg Zn-SP three times a week. A HFHS diet induced obesity and glucose intolerance and increased plasma levels of pro-inflammatory cytokines and transaminases. Zn-SP administration restored glucose homeostasis and reduced hepatic dysfunction and systemic inflammation. In the liver of HFHS mice, a robust accumulation of AGEs was detected, paralleled by increased expression of the main AGE receptor (RAGE) and depletion of glyoxalase-1, whereas Zn-SP administration efficiently prevented these alterations reducing local pro-inflammatory responses. 16S rRNA gene profiling of feces and ileum content revealed altered bacterial community structure in HFHS mice compared to both SD and HFHS + Zn-SP groups. Overall, our study demonstrates relevant anti-glycation properties of Zn-SP which contribute to preventing AGE production and/or stimulate AGE detoxification, leading to the improvement of diet-related dysbiosis and metabolic derangements.

Published
2024
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32. Letter to Editor regarding: 'Long latency responses in tongue muscle elicited by various stimulation sites in anesthetized humans - New insights into tongue-related brainstem reflexes'

Author

Denise Lima Medeiros de Melo, Enio Alberto Comerlato, Denise Spinola Pinheiro, and Gilberto Mastrocola Manzano

Subjects
Trigeminal-hypoglossal reflex, Trigeminal reflexes, Intraoperative neurophysiological monitoring, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2023
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34. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19

Author

Einstein, Andrew J., Paez, Diana, Dondi, Maurizio, Better, Nathan, Cerci, Rodrigo, Dorbala, Sharmila, Karthikeyan, Ganesan, Pascual, Thomas N.B., Shaw, Leslee J., Villines, Todd C., Vitola, Joao V., Williams, Michelle C., Pynda, Yaroslav, Hinterleitner, Gerd, Lu, Yao, Morozova, Olga, Xu, Zhuoran, Hirschfeld, Cole B., Cohen, Yosef, Erinne, Ikenna, Malkovskiy, Eli, Randazzo, Michael, Sewanan, Lorenzo, Shetty, Mrinali, Choi, Andrew, Lopez-Mattei, Juan, Parwani, Purvi, Goda, Artan, Shirka, Ervina, Bouyoucef, Salah, Chelghoum, Lydia, Mansouri, Farouk, Medjahedi, Abdelkader, Naili, Qais, Ridouh, Mokhtar, Alasia, Diego, Alberghina, Lucia, Aramayo, Natalia, Buchara, Diego, Busso, Franco Gabriel, Bustos Rivadero, Jose Javier, Camilletti, Jorge, Campanelli, Hugo, Campisi, Roxana, Castro, Ricardo Belisario, Daicz, Mariana, del Riego, Horacio, Dragonetti, Laura, Echazarreta, Diego, Erriest, Juan, Faccio, Fernando, Facello, Adolfo, Gallegos, Hugo, Geronazzo, Ricardo, Glait, Horacio, Hasbani, Victor, Jäger, Victor, Lewkowicz, Julio Manuel, Lotti, Jose, Maciel, Neiva, Masoli, Osvaldo, Mastrovito, Edgardo, Medus, Maria, Merani, Maria Fernanda, Molteni, Susana, Montecinos, Marcos, Parisi, Gustavo, Sueldo, Claudio Pereyra, Perez de Arenaza, Diego, Quintana, Luis, Radzinschi, Alejandro, Redruello, Marcela, Rodríguez, Marina, Rojas, Horacio, Acuña, Arturo Romero, Schere, Daniel, Traverso, Sonia, Vazquez, Gustavo, Zeffiro, Susana, Sakanyan, Mari, Beuzeville, Scott, Boktor, Raef, Crowley, Michael, Downie, D'Arne, Dwivedi, Girish, Elison, Barry, Farouque, Omar, Jasper, Kim, Joshi, Subodh, Lee, Joseph, Lee, Kenneth, Lui, Elaine, Mcconachie, Peter, Meaker, Joanne, Nandurkar, Dee, Neill, Johanne, O'Rourke, Edward, O'Sullivan, Patricia, Pandos, George, Premaratne, Manuja, Prior, David, Rutherford, Natalie, Saunders, Connor, Taubman, Kim, Tauro, Andrew, Taylor, Andrew, Theuerle, James, Thomas, Paul, Tow, Jonathan, Upton, Anthony, Vamadevan, Shankar, Wayne, Victor, Wegner, Eva Alina, Wong, David, Younger, John, Beitzke, Dietrich, Feuchtner, Gudrun, Sommer, Oliver, Weiss, Konrad, Maroz-Vadalazhskaya, Natallia, Tserakhau, Uladzimir, Homans, Filip, Van De Heyning, Caroline M., Araujo, Raúl, Soldat-Stankovic, Valentina, Stankovic, Sinisa, Almeida, Augusto, Anselmi, Carlos, Azevedo, Guilherme S.A., Bittencourt, Marcio Sommer, Pianta, Diego Bromfman, Cabeda, Estevan, Carreira, Lara, Coelho, Igor, de Amorim Fernandes, Fernando, de Lorenzo, Andrea, Delgado, Roberta, Erthal, Fernanda, Fernandes, Fabio, Fernandes, Juliano, Ferreira de Souza, Thiago, Foppa, Murilo, Matos Alves, Wilson Furlan, Gontijo, Cibele, Gottlieb, Ilan, Grossman, Gabriel, Albernaz Siqueira, Maria Helena, Nomura, Cesar Higa, Koga, Katia Hiromoto, Lima, Ronaldo, Lopes, Rafael, Marçal Filho, Hugo Humberto, Masiero, Paulo, Mastrocola, Luiz, Menezes de Siqueira, Maria Eduarda, Mesquita, Claudio, Naves, Danilo, Penna, Filipe, Pinto, Ibraim, Rocha, Thércio, Rocha, Juliana Leal, Rodrigues, Alfredo, Salioni, Leila, Sanches, Adelina, Santos, Marcelo, Da Silva, Leonardo Sara, Schvartzman, Paulo, Matushita, Cristina Sebastião, Senra, Tiago, Silva, Marcelo, Soares, Carlos Eduardo, Spiro, Bernardo, Suaide Silva, Carlos Eduardo, Torres, Rafael, Monte, Guilherme Urpia, Vilela, Andrea, Villa, Alexandre Volney, Vitola, Joao, Voss, Themissa, Waltrick, Roberto, Zapparoli, Marcello, Naseer, Hamid, Garcheva-Tsacheva, Marina, Ouattara, Tiémégna Florence, Thou, Sarameth, Varoeun, Soley, Abikhzer, Gad, Beanlands, Rob, Chetrit, Michael, Dabreo, Dominique, Dennie, Carole, Friedrich, Matthias, Hafez, Mohmmed Nassoh, Hanneman, Kate, Miller, Robert, Oikonomou, Anastasia, Roifman, Idan, Small, Gary, Tandon, Vikas, Trivedi, Adwait, White, James, Zukotynski, Katherine, Alay, Rita, Concha, Carmen, Massardo, Teresa, Abad, Pedro, Anzola, Kelly, Arturo, Harold, Benitez, Luis, Cadena, Alberto, Zamudio, Carlos Caicedo, Calderón, Antonio, Gutierrez Villamil, Claudia T., Jaimes, Claudia, Londono, Juan L., Lopez, Nelson, Merlano-Gaitan, Sonia, Murgieitio-Cabrera, Ramon, Valencia, Manuel, Vergel, Damiana, Santamaria, Alejandro Zuluaga, Solis, Felix, Batinic, Tonci, Franceschi, Maja, Paar, Maja Hrabak, Prpic, Marina, Felipe Batista, Cuba: Juan, Cabrera, Lazaro Omar, Peix, Amalia, Peña, Yamilé, Rochela Vázquez, Luis Manuel, Ntalas, Ioannis, Kaminek, Milan, Kincl, Vladimir, Lang, Otto, Abdulla, Jawdat, Bøttcher, Morten, Busk, Martin, Geisler, Uka, Gormsen, Lars C., Hansson, Nicolaj, Hess, Søren, Hove, Jens, Jensen, Lars Thorbjoern, Jensen, Magnus T., Kragholm, Kristian Hay, Nørgaard, Bjarne L., Øvrehus, Kristian, Rasmussen, Jan, Rønnow Sand, Niels Peter, Sondergaard, Hanne, Zaremba, Tomas, Speckter, Herwin, Amores, Nelson, Velez, Mayra Sanchez, Alrahman, Taghreed Abd, Elsamad, Sherif Abd, Abdelfattah, Alia, Allam, Adel, Elkaffas, Sameh, Hassan, Mona, Hussein, Elshaymaa, Ibrahim, Ahmed, Kandeel, Ahmed, Ali, Mohamed Mandour, Shaaban, Mahmoud, Flores, Camila, Gómez Leiva, Verónica Vanesa, Liiver, Anita, Larikka, Martti, Uusitalo, Valtteri, Agostini, Denis, Berger, Clothilde, Dietz, Matthieu, Hyafil, Fabien, Ohana, Mickaël, Prigent, Kevin, Regaieg, Hamza, Sarda-Mantel, Laure, H-Ici, Darach O., Ayetey, Harold, Angelidis, George, Fragkaki, Christina, Fragkiadaki, Chrysoula, Georgoulias, Panagiotis, Koutelou, Maria, Kyrozi, Elena, Lama, Niki, Prassopoulos, Vassilis, Spartalis, Michael, Zaglavara, Theodora, Gonzalez, Carla, Gutierrez, Goleat, Maldonado, Alejandro, Martinez, Yassine, Kovács, Attila, Szilveszter, Bálint, Banthia, Nilesh, Bhat, Vivek, Bhatia, Mona, Choudhury, Partha, Chowdekar, Vijay Sai, Christopher, Johann, Garg, Tushar, Goyal, Naresh Kumar, Gupta, Ripen Kumar, Gupta, Abhishek, Hephzibah, Julie, Jain, Shashank, Krupa, Jesu, Kumar, Parveen, Kumar, Sukriti, Lalchandani, Arati, Mishra, Animesh, Mishra, Vivaswan Dutt, Mohan, Parul, Ozair, Ahmad, Pandey, Shivani, Parameswaran, Ramanathapuram, Patel, Chetan, Patel, Tapan, Patel, Shivani, Vimala, Leena Robinson, Kumar Sarangi, Dr Pradosh, Sengupta, Shantanu, Sethi, Arvind, Sharma, Amit, Sharma, Awadhesh Kumar, Sharma, Punit, Shrigiriwar, Apurva, Singh, Santosh, Singh, Harpreet, Sood, Ashwani, Verma, Atul, Vyas, Ajay, Soeriadi, Erwin Affandi, Bun, Edison, Hutomo, Febby, Syawaluddin, Hilman, Yudistiro, Ryan, Albadr, Amjed, Assadi, Majid, Emami, Farshad, Emami-Ardekani, Alireza, Farzanehfar, Saeed, Jafari, Ramezan, Manafi-Farid, Reyhaneh, Tajik, Maryam, Arnson, Yoav, Fuchs, Shmuel, Goldkorn, Ronen, Kennedy, John, Leitman, Marina, Shalev, Aryeh, Acampa, Wanda, Albano, Domenico, Alongi, Pierpaolo, Arnone, Gaspare, Assante, Roberta, Baritussio, Anna, Bauckneht, Matteo, Bianco, Francesco, Bonfiglioli, Rachele, Bovenzi, Francesco, Bruno, Isabella, Bruno, Andrea, Busnardo, Elena, Califaretti, Elena, Casoni, Roberta, Censullo, Vittorio, Chierichetti, Franca, Chiocchi, Marcello, Cittanti, Corrado, Clemente, Alberto, Cuocolo, Alberto, De Rimini, Maria Luisa, De Vincentis, Giuseppe, Della Tommasina, Veronica, Dellegrottaglie, Santo, Erba, Paola Anna, Evangelista, Laura, Faggi, Lara, Faragasso, Evelina, Florimonte, Luigia, Frantellizzi, Viviana, Gatti, Marco, Gaudiano, Angela, Gelardi, Fabrizia, Gerali, Alberto, Gimelli, Alessia, Guglielmo, Marco, Leccisotti, Lucia, Liga, Riccardo, Liguori, Carlo, Longo, Giampiero, Maffione, Margherita, Marcassa, Claudio, Matassa, Giovanni, Mele, Donato, Milan, Elisa, Mircoli, Luca, Paccagnella, Andrea, Pacella, Sara, Padovano, Federica, Pellegrini, Dario, Pergola, Valeria, Pugliese, Luca, Quartuccio, Natale, Rampin, Lucia, Ricci, Fabrizio, Rubini, Giuseppe, Russo, Vincenzo, Sambuceti, Gianmario, Scatteia, Alessandra, Sciagrà, Roberto, Spidalieri, Gianluca, Stefanelli, Antonella, Tedeschi, Carlo, Ventroni, Guido, Baugh, Dainia, Madu, Ernest, Aikawa, Tadao, Asano, Hiroshi, Fujimoto, Shinichiro, Fujise, Koichiro, Fukushima, Yoshimitsu, Fukuyama, Kae, Ichikawa, Yasutaka, Ideguchi, Reiko, Iguchi, Nobuo, Imai, Masamichi, Ishimura, Hayato, Isobe, Satoshi, Ito, Kimiteru, Izawa, Yu, Kadokami, Toshiaki, Kasai, Tokuo, Kato, Takao, Kawamoto, Takashi, Kiryu, Shigeru, Kumita, Shinichiro, Manabe, Osamu, Maruno, Hirotaka, Matsumoto, Naoya, Miyagawa, Masao, Moroi, Masao, Nagamachi, Shigeki, Nakajima, Kenichi, Nakazato, Ryo, Nanasato, Mamoru, Naya, Masanao, Norikane, Takashi, Ohta, Yasutoshi, Otomi, Yoichi, Otsuka, Hideki, Oyama-Manabe, Noriko, Saito, Masaki, Sarai, Masayoshi, Sato, Junichi, Sato, Daisuke, Shiraishi, Shinya, Takanami, Kentaro, Takehana, Kazuya, Taniguchi, Yasuyo, Teragawa, Hiroki, Tomizawa, Nobuo, Umeji, Kyoko, Wakabayashi, Yasushi, Yamada, Shinichiro, Yamazaki, Shinya, Yoneyama, Tatsuya, Rawashdeh, Mohammad, Dautov, Tairkhan, Makhdomi, Khalid, Abass, Mostafa, Garashi, Masoud, Siraj, Qaisar, Kalnina, Marika, Haidar, Mohamad, Komiagiene, Renata, Kviecinskiene, Giedre, Vajauskas, Donatas, Karim, Noor Khairiah A., Doucoure, Mady, Reichmuth, Luise, Samuel, Anthony, Dieng, Mohamed Lemine, Naojee, Ambedhkar Shantaram, Hernandez, Estrella Aguilera, Alducin Tellez, Cesar Rene, Alexánderson-Rosas, Erick, Barragan, Erika, Cabada, Manuel, Calderón, Daniel, Carvajal-Juarez, Isabel, Esparza, José, Gama-Moreno, Manlio Gerardo, Quinto, Virginia Garcia, Gonzalez, Nelsy Coromoto, Herrera-Zarza, Mary Carmen, Meave, Aloha, Medina Verdugo, Jesus Gregorio, Melendez, Gabriela, Morales Murguia, Rafael Humberto, Navarro Quiroz, Carlos Salvador, Ornelas, Mario, Preciado-Anaya, Andres, Preciado-Gutiérrez, Oscar Ulises, Puente, Adriana, Salazar, Aristóteles Ramírez, Rosales Uvera, Sandra Graciela, Rosales-Uvera, Sandra, Serna Macias, Jose Antonio, Sierra-Galan, Lilia, Sierra-Galan, Lilia M., Tirado Alderete, Juan Carlos, Vallejo, Enrique, Faraggi, Marc, Sereegotov, Erdenechimeg, Ben Rais, Nouzha, Alaoui, Nadia Ismaili, Kyiphyu, Thiri, Oo, Su Thet, Win, Soe Myat, Zar, Htin, Ghimire, Ram, Neupane, Madhu, Glaudemans, Andor, Slart, Riemer, Verschure, Derk, Allen, Berry, Edmond, John, Mckenzie, Clare, Tie, Stuart, Van Pelt, Niels, Worthington, Kirsten, Young, Calum, Soli, Idrissa Adamou, Kana, Shehu, Onubogu, Uchenna, Sani, Mahmoud, Bråten, Anders Tjellaug, Jørgensen, Arve, Vassbotn, Hanne-Elin, Al Dhuhli, Humoud, Jawa, Zabah, Tag, Naima, Fatima, Shazia, Imran, Muhammad Babar, Younis, Muhammad Numair, Saadullah, Mohammad, Malo, Yariela Herrera, Lenturut-Katal, Dora, Castillo, Manuel, Ortellado, José, Akhter, Afroza, Cader, F. Aaysha, Hussain, Raihan, Khan, Saidur Rahman, Mandal, Tapati, Nasreen, Faria, An, Yunqiang, Cao, Dianbo, Gong, Lianggeng, Hou, Yang, Jia, Chongfu, Li, Tao, Li, Caiying, Liu, Hui, Liu, Wenya, Liu, Jinkang, Lu, Bin, Ng, Ming-Yen, Shi, Heshui, Tang, Chunxiang, Wang, Ximing, Wang, Zhaoqian, Wang, Yining, Wu, Jiang, Yi, Yan, Yuan, Li, Zhang, Tong, Zhang, Longjiang, Chavez, Edith, Cruz, Carlos, Llontop, Christian, Morales, Rosanna, Abrihan, Paz, Bustos-Barroso, Asela, Duldulao-Ogbac, Michele, Eduarte, Christopher, Obaldo, Jerry, Quinon, Alvin, San Juan, Belinda, San Juan, Carlo Joe, Sauler-Gomez, Marie Rhiamar, Uy, Mila, Kostkiewicz, Magdalena, Kunikowska, Jolanta, Teresinska, Anna, Urbanik, Tomasz, Bettencourt, Nuno, Fontes-Carvalho, Ricardo, Gavina, Cristina, Gonçalves, Lino, Macedo, Filipe, Moreno, Nuno, Sousa, Carla, Timoteo, Ana Teresa, Vidigal, Maria João, Al Heidous, Mahmoud, Ramanathan, Subramaniyan, Arnous, Samer, Aytani, Said, Byrne, Angela, Gleeson, Tadhg, Kerins, David, O'Brien, Julie, Bang, Ji-In, Bom, Henry, Cheon, Miju, Cheon, Gi Jeong, Cho, Sang-Geon, Hong, Chae Moon, Jeong, Yong Hyu, Kang, Won Jun, Kang, Yeon-Koo, Kim, Ji-Young, Oh, So Won, So, Young, Song, Ho-Chun, Won, Kyoung Sook, Yoo, Soo Woong, Mitevska, Irena, Vavlukis, Marija, Salobir, Barbara Gužic, Štalc, Monika, Benedek, Theodora, Pop, Marian, Stan, Claudiu, Ansheles, Alexey, Dariy, Olga, Gagarina, Nina, Itskovich, Irina, Karalkin, Anatoliy, Kokov, Alexander, Marina, Gulya, Migunova, Ekaterina, Pospelov, Viktor, Ryzhkova, Daria, Sayfullina, Guzaliya, Sergienko, Vladimir, Shurupova, Irina, Sinitsyn, Valentin, Vakhromeeva, Margarita, Valiullina, Nailia, Zavadovsky, Konstantin, Zhuravlev, Kirill, Abazid, Rami, Al Garni, Turki, Alasnag, Mirvat, Aljizeeri, Ahmed, Amer, Hamid, Amro, Ahmad, Hamdy, Hesham, Smettei, Osama, Saranovic, Dragana Sobic, Vlajkovic, Marina, Keng, Felix, See, Jason, Berecova, Zuzana, Mistinova, Jana Polakova, Evbuomwan, Osayande, Govender, Nerisha, Hack, Jonathan, Hadebe, Bawinile, Hlongwa, Khanyisile, Kaplan, Mitchell, Lakhi, Hoosen, Milos, Katarina, Modiselle, Moshe, More, Stuart, Muambadzi, Ntanganedzeni, Scholtz, Leonie, Barreiro-Perez, Manuel, Blanco, Isabel, Broncano, Jordi, Camarero, Alicia, Casáns-Tormo, Irene, De Haro, Javier, Flotats, Albert, García, Elia, Mendiguchia, Ceferino Gutierrez, Jimenez-Heffernan, Amelia, Leta, Ruben, Diaz, Javier Lopez, Vega, Luis Lumbreras, Manovel-Sánchez, Ana, Monzonis, Amparo Martinez, Patrut, Bianca, Pubul, Virginia, Perez, Ricardo Ruano, Zeidan, Nahla, Nanayakkara, Damayanthi, Suliman, Ahmed, Engblom, Henrik, Murtadha, Mustafa, Ostenfeld, Ellen, Simonsson, Magnus, Alkadhi, Hatem, Buechel, Ronny Ralf, Burger, Peter, Gräni, Christoph, Kamani, Christel, Kawel-Böhm, Nadine, Klaeser, Bernd, Manka, Robert, Prior, John, Kaewchur, Tawika, Khiewvan, Benjapa, Kositwattanarerk, Arpakorn, Namwongprom, Sirianong, Thientunyakit, Tanyaluck, Sayman, Haluk Burcak, Yüksel, Mahmut, Sebikali, Mugisha Julius, Okello, Emmy, Korol, Pavlo, Noverko, Iryna, Satyr, Maryna, Ahmad, Tahir, Alfakih, Khaled, Andrade, Ivo, Buckingham, Susan, Bularga, Anda, Carpenter, John-Paul, Cole, Graham, Cusack, David, David, Sarojini, Davis, Patrick, Fairbairn, Timothy, Ghosh, Arjun, Ramkumar, Prasad Guntur, Hamilton, Mark, Haque, Faisal, Hudson, Benjamin, Johnstone, Annette, Karthikeyan, V.J., Kay, Mike, Khan, Mohammad Ali, Kitt, Jamie, Low, Chen Sheng, Mcalindon, Elisa, Mccreavy, David, Morrissey, Brian, Motwani, Manish, Na, Dilip, Nicol, Edward, Patel, Dilip, Rodrigues, Jonathan, Rofe, Chris, Schofield, Rebecca, Semple, Thomas, Sheikh, Azeem, Sinha, Apurva, Subedi, Deepak, Topping, William, Tweed, Katherine, Underwood, Stephen Richard, Weir-Mccall, Jonathan, Zuhairy, Hamed, Abbasi, Taimur, Abohashem, Shady, Abramson, Sandra, Al-Mallah, Mouaz, Kumar, Mohan Ashok, Balmer-Swain, Mallory, Berman, Daniel, Bernheim, Adam, Bhatti, Sabha, Biederman, Robert, Bieging, Erik, Bingham, Scott, Bloom, Stephen, Blue, Sean, Borges, Andressa, Branch, Kelley, Bravo, Paco, Buddhe, Sujatha, Budoff, Matthew, Bullock-Palmer, Renée, Cahill, Michael, Candela, Candace, Cao, Jane, Chatterjee, Saurav, Chatzizisis, Yiannis, Chaudhuri, Nita Ray, Cheezum, Michael, Chelliah, Anjali, Chen, Tiffany, Chen, Marcus, Chen, Lu, Chokshi, Aalap, Chung, Jina, Danciu, Sorin, DeSisto, William, Dilorenzo, Michael, Doukky, Rami, Duvall, William, Ferencik, Maros, Foster, Cameron, Fuisz, Anthon, Gannon, Michael, German, David, Gerson, Myron, Geske, Jeffrey, Hage, Fadi, Haider, Agha, Haider, Sofia, Hamirani, Yasmin, Hassen, Karen, Hendel, Robert, Henkel, Jacqueline, Horgan, Stephen, Hyun, Mark, Janardhanan, Rajesh, Jerome, Scott, Kalra, Dinesh, Kassop, David, Kinkhabwala, Mona, Kinzfogl, George, Koch, Bernard, Koweek, Lynne, Krepp, Joseph, Kwon, Younghoon, Layer, Jay, Lesser, John, Leung, Steve, Lisske, Bernadette, Magurany, Kathleen, Markowitz, Jeremy, Mccullough, Brenda, Moalemi, Azita, Moffitt, Chanan, Montanez, Juan, Moore, Warren, Morayati, Shamil, Mossa-Basha, Mahmud, Mrsic, Zorana, Murthy, Venkatesh, Nagpal, Prashant, Nelson, Katarina, Nijjar, Prabhjot, O’Quinn, Rupal, Passen, Edward, Patel, Toral, Patil, Pravin, Pursnani, Amit, Quachang, Nancy, Rabbat, Mark, Ranjan, Pragya, Lozano, Patricia Rodriguez, Schemmer, Mary, Seifried, Rebecca, Shah, Nishant, Shah, Amee, Shanbhag, Sujata, Sharma, Gaurav, Skotnicki, Robert, Sobczak, Michael, Soman, Prem, Sorrell, Vincent, Srichai, Monvadi, Streeter, Jim, Strickland, Leah, Suliman, Suliman, Tebyanian, Naghmeh, Thomas, Dustin, Thompson, Randall, Uretsky, Seth, Vallurupalli, Srikanth, Vandyck-Acquah, Marian, Verma, Vikas, Villines, Todd, Weinstein, Joseph, Wolinsky, David, Zareba, Karolina, Zgaljardic, Michael, Beretta, Mario, Ferrando, Rodolfo, Kapitan, Miguel, Mut, Fernando, Djuraev, Omoa, Rozikhodjaeva, Gulnora, Vera, Luisa, Duc, Binh Duong, Nguyen, Xuan Canh, Hiep Nguyen, Phuoc Minh, Hirschfeld, Cole, Choi, Andrew D., Ansheles, Alexey A., Kudo, Takashi, Bucciarelli-Ducci, Chiara, Nørgaard, Bjarne Linde, Maurovich-Horvat, Pál, Louw, Lizette, Allam, Adel H., and Narula, Jagat

Published
2022
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35. Sensory Evaluation and Consumers' Acceptance of a Low Glycemic and Gluten-Free Carob-Based Bakery Product.

Author

Esposito, Luigi, Casolani, Nicola, Ruggeri, Marco, Spizzirri, Umile Gianfranco, Aiello, Francesca, Chiodo, Emilio, Martuscelli, Maria, Restuccia, Donatella, and Mastrocola, Dino

Subjects
LOCUST bean gum, CAROB, GLYCEMIC index, BAKED products, CONSUMER preferences
Abstract

Carob pulp flour has antidiabetic and antioxidant activities, is naturally sweet, and is rich in fibers. It is obtained from carob pod pulp from the evergreen tree Ceratonia siliqua L., which is grown in Mediterranean areas and is known for locust bean gum production. Despite its valuable effects on health, such as the modulation of the glycemic index, this ingredient has a tremendous impact on technological and hedonic features, mainly on color, flavor, and texture. In this paper, the qualitative features and consumers' acceptance of a carob-based gluten-free bakery product where rice flour was substituted at 40% with carob pulp flour were studied. A panel group of experts described the bread as dark, quite dense, sweet, aromatic, and with a limited bubble dispersion. On the other hand, the sensory assessment and the willingness to pay of consumers were assessed in two groups (a fully informed one about heathy attributes of the food and a blind one). The results indicated a moderate appreciation of the overall quality of the product (average score between 4 and 5 points on a 9-point Likert scale). The information about the food's healthy properties and the ability to maintain a low glycemic index did not enhance the consumers' perception of the product, while previous knowledge and involvement in the product consumption were perceived to have primary importance regarding the final consumers' choice. Finally, an accelerated shelf-life test was run on the packaged snack to evaluate the general quality and stability. The protective packaging helped in limiting bread decay and maintaining the textural characteristics. [ABSTRACT FROM AUTHOR]

Published
2024
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36. New Perspectives to Enhance Wastes and By-Products from Agro-Food Processing

Author

Maria Martuscelli, Luigi Esposito, Donatella Restuccia, Meijin Guo, and Dino Mastrocola

Subjects
n/a, Chemical technology, TP1-1185
Abstract

The exploitation of by-products and waste from the agri-food industry represents a sustainable approach within the frame of the circular economy, the basis of the European Green Deal and ecological transition [...]

Published
2023
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37. Food Choices in Snacking Moments and Biogenic Amines Exposure: A Preliminary Observation of Children from the Abruzzo Region

Author

Luigi Esposito, Dino Mastrocola, and Maria Martuscelli

Subjects
snacking, meal composition, food choices, biogenic amines, Plant ecology, QK900-989, Animal biochemistry, QP501-801, Biology (General), QH301-705.5
Abstract

Snacking outside of main meals is common and often a dietary requirement, especially for children and toddlers. This habit has both social and educative dimensions, as it has become an established moment in people’s daily routines. We conducted an easy online survey involving students and their families from schools in the Abruzzo region, Italy. The aim of the survey was to understand the participants’ habits, food choices, and meal composition during snack time. Additionally, we inquired about their general health state. Our interest lies in knowing more about this population, with sufficient data to observe whether habits and food choices may be accountable for exposure to biogenic amines (BAs). BAs are unavoidable natural compounds that come from the catabolism of amino acids in tissues. They are possibly involved in reactions such as allergic-like manifestations, abdominal pain, and more severe symptoms depending on individual sensitivity. The action of BAs can be augmented by the intake of foods, mainly fermented products, which are common in everyday diets. We collected 300 responses from students ranging from 11 to 18 years old. The most popular foods eaten were sweets (pastries, cakes) and sweet bakery products, followed by yogurt-based and milk-based products (30% and 23%, respectively). Most students (58%) reported having a snack moment daily. The population was generally in good health, but some reported experiencing light discomfort after snacking, such as transient gastrointestinal pain, headache, and dermatological symptoms (8.7%, 2%, and 0.7% of the total, respectively). All this information may be linked and added to the knowledge about BA content in foods and their potential impact on health.

Published
2023
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38. Who Cares about Biogenic Amines?

Author

Luigi Esposito, Dino Mastrocola, and Maria Martuscelli

Subjects
n/a, Chemical technology, TP1-1185
Abstract

Biogenic amines (BAs) have been under study since the early 1970s [...]

Published
2023
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40. Horror Ludens: Using Fear to Construct Meaning in Video Games

Author

Mastrocola, Vicente Martin, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, and Fang, Xiaowen, editor

Published
2021
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42. A Laparoscopic Conservative Surgery Approach to Puerperium Complicated by Uterine Prolapse After Vaginal Delivery: A Case Series

Author

Marta Seca, Paola Algeri, Laura Colonna, Nunzia Mastrocola, and Silvia Von Wunster

Subjects
Hysterocele, Vaginal Prolapse, Laparoscopy, Laparoscopic Hysteropexy, Hysterosacropexy, Gynecology and obstetrics, RG1-991
Abstract

Objective: In fertile women, hysterocele is a rare condition. Genital prolapse can be treated conservatively with laparoscopic hysterosacropexy. It is objected to present a successful case series of laparoscopic hysteropexy for patients with hysterocele after vaginal delivery. Case report: We presented a successful case series of three patients with III or IV degrees of hysterocele who were treated conservatively with an uncomplicated laparoscopic hysteropexy within a year of delivery. Given our patients' young ages and the fact that they all have infant children at home, we chose a conservative surgery performed laparoscopically due to the lower surgical impact and quicker return to normal life. All surgical procedures were successfully performed, without complications, with a prompt recovery of all women and with a regular subsequent follow-up, without recurrence nowadays. Conclusion: For young women who have not terminated their desire to bear children, laparoscopic hysterepexy may be a safe and effective surgical option.

Published
2023
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43. Corrigendum to “Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation’’ [Biochem. Pharmacol. 85(2) (2013) 257–264]

Author

Collino, Massimo, primary, Benetti, Elisa, additional, Rogazzo, Mara, additional, Mastrocola, Raffaella, additional, Yaqoob, Muhammed M., additional, Aragno, Manuela, additional, Theimermann, Christroph, additional, and Fantozzi, Roberto, additional

Published
2024
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45. Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia

Author

Takashi Kudo, MD, PhD, Ryan Lahey, MD, PhD, Cole B. Hirschfeld, MD, Michelle C. Williams, MBChB, PhD, Bin Lu, MD, PhD, Mirvat Alasnag, MD, Mona Bhatia, MD, Hee-Seung Henry Bom, MD, PhD, Tairkhan Dautov, MD, Reza Fazel, MD, MSc, Ganesan Karthikeyan, MD, Felix Y.J. Keng, MBBS, Ronen Rubinshtein, MD, Nathan Better, MBBS, Rodrigo Julio Cerci, MD, Sharmila Dorbala, MD, MPH, Paolo Raggi, MD, Leslee J. Shaw, PhD, Todd C. Villines, MD, João V. Vitola, MD, PhD, Andrew D. Choi, MD, Eli Malkovskiy, Benjamin Goebel, BS, Yosef A. Cohen, BA, Michael Randazzo, MD, Thomas N.B. Pascual, MD, Yaroslav Pynda, MSc, Maurizio Dondi, MD, PhD, Diana Paez, MD, MEd, Andrew J. Einstein, MD, PhD, Andrew J. Einstein, Diana Paez, Maurizio Dondi, Nathan Better, Rodrigo Cerci, Sharmila Dorbala, Thomas N.B. Pascual, Paolo Raggi, Leslee J. Shaw, Todd C. Villines, Joao V. Vitola, Michelle C. Williams, Yaroslav Pynda, Gerd Hinterleitner, Yao Lu, Olga Morozova, Zhuoran Xu, Cole B. Hirschfeld, Yosef Cohen, Benjamin Goebel, Michael Randazzo, Andrew Choi, Juan Lopez-Mattei, Purvi Parwani, Mohammad Nawaz Nasery, Artan Goda, Ervina Shirka, Rabie Benlabgaa, Salah Bouyoucef, Abdelkader Medjahedi, Qais Nailli, Mariela Agolti, Roberto Nicolas Aguero, Maria del Carmen Alak, Lucia Graciela Alberguina, Guillermo Arroñada, Andrea Astesiano, Alfredo Astesiano, Carolina Bas Norton, Pablo Benteo, Juan Blanco, Juan Manuel Bonelli, Jose Javier Bustos, Raul Cabrejas, Jorge Cachero, Roxana Campisi, Alejandro Canderoli, Silvia Carames, Patrícia Carrascosa, Ricardo Castro, Oscar Cendoya, Luciano Martin Cognigni, Carlos Collaud, Claudia Cortes, Javier Courtis, Daniel Cragnolino, Mariana Daicz, Alejandro De La Vega, Silvia Teresa De Maria, Horacio Del Riego, Fernando Dettori, Alejandro Deviggiano, Laura Dragonetti, Mario Embon, Ruben Emilio Enriquez, Jorge Ensinas, Fernando Faccio, Adolfo Facello, Diego Garofalo, Ricardo Geronazzo, Natalia Gonza, Lucas Gutierrez, Miguel Angel Guzzo, Victor Hasbani, Melina Huerin, Victor Jäger, Julio Manuel Lewkowicz, Maria Nieves A. López De Munaín, Jose Maria Lotti, Alejandra Marquez, Osvaldo Masoli, Osvaldo Horacio Masoli, Edgardo Mastrovito, Matias Mayoraz, Graciela Eva Melado, Anibal Mele, Maria Fernanda Merani, Alejandro Horacio Meretta, Susana Molteni, Marcos Montecinos, Eduardo Noguera, Carlos Novoa, Claudio Pereyra Sueldo, Sebastian Perez Ascani, Pablo Pollono, Maria Paula Pujol, Alejandro Radzinschi, Gustavo Raimondi, Marcela Redruello, Marina Rodríguez, Matías Rodríguez, Romina Lorena Romero, Arturo Romero Acuña, Federico Rovaletti, Lucas San Miguel, Lucrecia Solari, Bruno Strada, Sonia Traverso, Sonia Simona Traverzo, Maria del Huerto Velazquez Espeche, Juan Sebastian Weihmuller, Juan Wolcan, Susana Zeffiro, Mari Sakanyan, Scott Beuzeville, Raef Boktor, Patrick Butler, Jennifer Calcott, Loretta Carr, Virgil Chan, Charles Chao, Woon Chong, Mark Dobson, D'Arne Downie, Girish Dwivedi, Barry Elison, Jean Engela, Roslyn Francis, Anand Gaikwad, Ashok Gangasandra Basavaraj, Bruce Goodwin, Robert Greenough, Christian Hamilton-Craig, Victar Hsieh, Subodh Joshi, Karin Lederer, Kenneth Lee, Joseph Lee, John Magnussen, Nghi Mai, Gordon Mander, Fiona Murton, Dee Nandurkar, Johanne Neill, Edward O'Rourke, Patricia O'Sullivan, George Pandos, Kunthi Pathmaraj, Alexander Pitman, Rohan Poulter, Manuja Premaratne, David Prior, Lloyd Ridley, Natalie Rutherford, Hamid Salehi, Connor Saunders, Luke Scarlett, Sujith Seneviratne, Deepa Shetty, Ganesh Shrestha, Jonathan Shulman, Vijay Solanki, Tony Stanton, Murch Stuart, Michael Stubbs, Ian Swainson, Kim Taubman, Andrew Taylor, Paul Thomas, Steven Unger, Anthony Upton, Shankar Vamadevan, William Van Gaal, Johan Verjans, Demetrius Voutnis, Victor Wayne, Peter Wilson, David Wong, Kirby Wong, John Younger, Gudrun Feuchtner, Siroos Mirzaei, Konrad Weiss, Natallia Maroz-Vadalazhskaya, Olivier Gheysens, Filip Homans, Rodrigo Moreno-Reyes, Agnès Pasquet, Veronique Roelants, Caroline M. Van De Heyning, Raúl Araujo Ríos, Valentina Soldat-Stankovic, Sinisa Stankovic, Maria Helena Albernaz Siqueira, Augusto Almeida, Paulo Henrique Alves Togni, Jose Henrique Andrade, Luciana Andrade, Carlos Anselmi, Roberta Araújo, Guilherme Azevedo, Sabbrina Bezerra, Rodrigo Biancardi, Gabriel Blacher Grossman, Simone Brandão, Diego Bromfman Pianta, Lara Carreira, Bruno Castro, Tien Chang, Fernando Cunali, Jr., Roberto Cury, Roberto Dantas, Fernando de Amorim Fernandes, Andrea De Lorenzo, Robson De Macedo Filho, Fernanda Erthal, Fabio Fernandes, Juliano Fernandes, Thiago Ferreira De Souza, Wilson Furlan Alves, Bruno Ghini, Luiz Goncalves, Ilan Gottlieb, Marcelo Hadlich, Vinícius Kameoka, Ronaldo Lima, Adna Lima, Rafael Willain Lopes, Ricardo Machado e Silva, Tiago Magalhães, Fábio Martins Silva, Luiz Eduardo Mastrocola, Fábio Medeiros, José Claudio Meneghetti, Vania Naue, Danilo Naves, Roberto Nolasco, Cesar Nomura, Joao Bruno Oliveira, Eduardo Paixao, Filipe Penna De Carvalho, Ibraim Pinto, Priscila Possetti, Mayra Quinta, Rodrigo Rizzo Nogueira Ramos, Ricardo Rocha, Alfredo Rodrigues, Carlos Rodrigues, Leila Romantini, Adelina Sanches, Sara Santana, Leonardo Sara da Silva, Paulo Schvartzman, Cristina Sebastião Matushita, Tiago Senra, Afonso Shiozaki, Maria Eduarda Menezes de Siqueira, Cristiano Siqueira, Paola Smanio, Carlos Eduardo Soares, José Soares Junior, Marcio Sommer Bittencourt, Bernardo Spiro, Cláudio Tinoco Mesquita, Jorge Torreao, Rafael Torres, Marly Uellendahl, Guilherme Urpia Monte, Otávia Veríssimo, Estevan Vieira Cabeda, Felipe Villela Pedras, Roberto Waltrick, Marcello Zapparoli, Hamid Naseer, Marina Garcheva-Tsacheva, Irena Kostadinova, Youdaline Theng, Gad Abikhzer, Rene Barette, Benjamin Chow, Dominique Dabreo, Matthias Friedrich, Ria Garg, Mohammed Nassoh Hafez, Chris Johnson, Marla Kiess, Jonathon Leipsic, Eugene Leung, Robert Miller, Anastasia Oikonomou, Stephan Probst, Idan Roifman, Gary Small, Vikas Tandon, Adwait Trivedi, James White, Katherine Zukotynski, Jose Canessa, Gabriel Castro Muñoz, Carmen Concha, Pablo Hidalgo, Cesar Lovera, Teresa Massardo, Luis Salazar Vargas, Pedro Abad, Harold Arturo, Sandra Ayala, Luis Benitez, Alberto Cadena, Carlos Caicedo, Antonio Calderón Moncayo, Sharon Gomez, Claudia T. Gutierrez Villamil, Claudia Jaimes, Juan Londoño, Juan Luis Londoño Blair, Luz Pabon, Mauricio Pineda, Juan Carlos Rojas, Diego Ruiz, Manuel Valencia Escobar, Andres Vasquez, Damiana Vergel, Alejandro Zuluaga, Isabel Berrocal Gamboa, Gabriel Castro, Ulises González, Ana Baric, Tonci Batinic, Maja Franceschi, Maja Hrabak Paar, Mladen Jukic, Petar Medakovic, Viktor Persic, Marina Prpic, Ante Punda, Juan Felipe Batista, Juan Manuel Gómez Lauchy, Yamile Marcos Gutierrez, Rayner Menéndez, Amalia Peix, Luis Rochela, Christoforos Panagidis, Ioannis Petrou, Vaclav Engelmann, Milan Kaminek, Vladimír Kincl, Otto Lang, Milan Simanek, Jawdat Abdulla, Morten Bøttcher, Mette Christensen, Lars Christian Gormsen, Philip Hasbak, Søren Hess, Paw Holdgaard, Allan Johansen, Kasper Kyhl, Bjarne Linde Norgaard, Kristian Altern Øvrehus, Niels Peter Rønnow Sand, Rolf Steffensen, Anders Thomassen, Bo Zerahn, Alfredo Perez, Giovanni Alejandro Escorza Velez, Mayra Sanchez Velez, Islam Shawky Abdel Aziz, Mahasen Abougabal, Taghreed Ahmed, Adel Allam, Ahmed Asfour, Mona Hassan, Alia Hassan, Ahmed Ibrahim, Sameh Kaffas, Ahmed Kandeel, Mohamed Mandour Ali, Ahmad Mansy, Hany Maurice, Sherif Nabil, Mahmoud Shaaban, Ana Camila Flores, Anne Poksi, Juhani Knuuti, Velipekka Kokkonen, Martti Larikka, Valtteri Uusitalo, Matthieu Bailly, Samuel Burg, Jean-François Deux, Vincent Habouzit, Fabien Hyafil, Olivier Lairez, Franck Proffit, Hamza Regaieg, Laure Sarda-Mantel, Vania Tacher, Roman P. Schneider, Harold Ayetey, George Angelidis, Aikaterini Archontaki, Sofia Chatziioannou, Ioannis Datseris, Christina Fragkaki, Panagiotis Georgoulias, Sophia Koukouraki, Maria Koutelou, Eleni Kyrozi, Evangelos Repasos, Petros Stavrou, Pipitsa Valsamaki, Carla Gonzalez, Goleat Gutierrez, Alejandro Maldonado, Klara Buga, Ildiko Garai, Pál Maurovich-Horvat, Erzsébet Schmidt, Balint Szilveszter, Edit Várady, Nilesh Banthia, Jinendra Kumar Bhagat, Rishi Bhargava, Vivek Bhat, Mona Bhatia, Partha Choudhury, Vijay Sai Chowdekar, Aparna Irodi, Shashank Jain, Elizabeth Joseph, Sukriti Kumar, Prof Dr Girijanandan Mahapatra, Deepanjan Mitra, Bhagwant Rai Mittal, Ahmad Ozair, Chetan Patel, Tapan Patel, Ravi Patel, Shivani Patel, Sudhir Saxena, Shantanu Sengupta, Santosh Singh, Bhanupriya Singh, Ashwani Sood, Atul Verma, Erwin Affandi, Padma Savenadia Alam, Edison Edison, Gani Gunawan, Habusari Hapkido, Basuki Hidayat, Aulia Huda, Anggoro Praja Mukti, Djoko Prawiro, Erwin Affandi Soeriadi, Hilman Syawaluddin, Amjed Albadr, Majid Assadi, Farshad Emami, Golnaz Houshmand, Majid Maleki, Maryam Tajik Rostami, Seyed Rasoul Zakavi, Eed Abu Zaid, Svetlana Agranovich, Yoav Arnson, Rachel Bar-Shalom, Alex Frenkel, Galit Knafo, Rachel Lugassi, Israel Shlomo Maor Moalem, Maya Mor, Noam Muskal, Sara Ranser, Aryeh Shalev, Domenico Albano, Pierpaolo Alongi, Gaspare Arnone, Elisa Bagatin, Sergio Baldari, Matteo Bauckneht, Paolo Bertelli, Francesco Bianco, Rachele Bonfiglioli, Roberto Boni, Andrea Bruno, Isabella Bruno, Elena Busnardo, Elena Califaretti, Luca Camoni, Aldo Carnevale, Roberta Casoni, Armando Ugo Cavallo, Giorgio Cavenaghi, Franca Chierichetti, Marcello Chiocchi, Corrado Cittanti, Mauro Colletta, Umberto Conti, Alberto Cossu, Alberto Cuocolo, Marco Cuzzocrea, Maria Luisa De Rimini, Giuseppe De Vincentis, Eleonora Del Giudice, Alberico Del Torto, Veronica Della Tommasina, Rexhep Durmo, Paola Anna Erba, Laura Evangelista, Riccardo Faletti, Evelina Faragasso, Mohsen Farsad, Paola Ferro, Luigia Florimonte, Viviana Frantellizzi, Fabio Massimo Fringuelli, Marco Gatti, Angela Gaudiano, Alessia Gimelli, Raffaele Giubbini, Francesca Giuffrida, Salvatore Ialuna, Riccardo Laudicella, Lucia Leccisotti, Lucia Leva, Riccardo Liga, Carlo Liguori, Giampiero Longo, Margherita Maffione, Maria Elisabetta Mancini, Claudio Marcassa, Elisa Milan, Barbara Nardi, Sara Pacella, Giovanna Pepe, Gianluca Pontone, Sabina Pulizzi, Natale Quartuccio, Lucia Rampin, Fabrizio Ricci, Pierluigi Rossini, Giuseppe Rubini, Vincenzo Russo, Gian Mauro Sacchetti, Gianmario Sambuceti, Massimo Scarano, Roberto Sciagrà, Massimiliano Sperandio, Antonella Stefanelli, Guido Ventroni, Stefania Zoboli, Dainia Baugh, Duane Chambers, Ernest Madu, Felix Nunura, Hiroshi Asano, Chimura Misato Chimura, Shinichiro Fujimoto, Koichiro Fujisue, Tomohisa Fukunaga, Yoshimitsu Fukushima, Kae Fukuyama, Jun Hashimoto, Yasutaka Ichikawa, Nobuo Iguchi, Masamichi Imai, Anri Inaki, Hayato Ishimura, Satoshi Isobe, Toshiaki Kadokami, Takao Kato, Takashi Kudo, Shinichiro Kumita, Hirotaka Maruno, Hiroyuki Mataki, Masao Miyagawa, Ryota Morimoto, Masao Moroi, Shigeki Nagamachi, Kenichi Nakajima, Tomoaki Nakata, Ryo Nakazato, Mamoru Nanasato, Masanao Naya, Takashi Norikane, Yasutoshi Ohta, Satoshi Okayama, Atsutaka Okizaki, Yoichi Otomi, Hideki Otsuka, Masaki Saito, Sakata Yasushi Sakata, Masayoshi Sarai, Daisuke Sato, Shinya Shiraishi, Yoshinobu Suwa, Kentaro Takanami, Kazuya Takehana, Junichi Taki, Nagara Tamaki, Yasuyo Taniguchi, Hiroki Teragawa, Nobuo Tomizawa, Kenichi Tsujita, Kyoko Umeji, Yasushi Wakabayashi, Shinichiro Yamada, Shinya Yamazaki, Tatsuya Yoneyama, Mohammad Rawashdeh, Daultai Batyrkhanov, Tairkhan Dautov, Khalid Makhdomi, Kevin Ombati, Faridah Alkandari, Masoud Garashi, Tchoyoson Lim Coie, Sonexay Rajvong, Artem Kalinin, Marika Kalnina, Mohamad Haidar, Renata Komiagiene, Giedre Kviecinskiene, Mindaugas Mataciunas, Donatas Vajauskas, Christian Picard, Noor Khairiah A. Karim, Luise Reichmuth, Anthony Samuel, Mohammad Aaftaab Allarakha, Ambedhkar Shantaram Naojee, Erick Alexanderson-Rosas, Erika Barragan, Alejandro Becerril González-Montecinos, Manuel Cabada, Daniel Calderon Rodriguez, Isabel Carvajal-Juarez, Violeta Cortés, Filiberto Cortés, Erasmo De La Peña, Manlio Gama-Moreno, Luis González, Nelsy Gonzalez Ramírez, Moisés Jiménez-Santos, Luis Matos, Edgar Monroy, Martha Morelos, Mario Ornelas, Jose Alberto Ortga Ramirez, Andrés Preciado-Anaya, Óscar Ulises Preciado-Gutiérrez, Adriana Puente Barragan, Sandra Graciela Rosales Uvera, Sigelinda Sandoval, Miguel Santaularia Tomas, Lilia M. Sierra-Galan, Silvia Siu, Enrique Vallejo, Mario Valles, Marc Faraggi, Erdenechimeg Sereegotov, Srdja Ilic, Nozha Ben-Rais, Nadia Ismaili Alaoui, Sara Taleb, Khin Pa Pa Myo, Phyo Si Thu, Ram Kumar Ghimire, Bijoy Rajbanshi, Peter Barneveld, Andor Glaudemans, Jesse Habets, Klaas Pieter Koopmans, Jeroen Manders, Stefan Pool, Arthur Scholte, Asbjørn Scholtens, Riemer Slart, Paul Thimister, Erik-Jan Van Asperen, Niels Veltman, Derk Verschure, Nils Wagenaar, John Edmond, Chris Ellis, Kerryanne Johnson, Ross Keenan, Shaw Hua (Anthony) Kueh, Christopher Occleshaw, Alexander Sasse, Andrew To, Niels Van Pelt, Calum Young, Teresa Cuadra, Hector Bladimir Roque Vanegas, Idrissa Adamou Soli, Djibrillou Moussa Issoufou, Tolulope Ayodele, Chibuzo Madu, Yetunde Onimode, Elen Efros-Monsen, Signe Helene Forsdahl, Jenni-Mari Hildre Dimmen, Arve Jørgensen, Isabel Krohn, Pål Løvhaugen, Anders Tjellaug Bråten, Humoud Al Dhuhli, Faiza Al Kindi, Naeema Al-Bulushi, Zabah Jawa, Naima Tag, Muhammad Shehzad Afzal, Shazia Fatima, Muhammad Numair Younis, Musab Riaz, Mohammad Saadullah, Yariela Herrera, Dora Lenturut-Katal, Manuel Castillo Vázquez, José Ortellado, Afroza Akhter, Dianbo Cao, Stephen Cheung, Xu Dai, Lianggeng Gong, Dan Han, Yang Hou, Caiying Li, Tao Li, Dong Li, Sijin Li, Jinkang Liu, Hui Liu, Bin Lu, Ming Yen Ng, Kai Sun, Gongshun Tang, Jian Wang, Ximing Wang, Zhao-Qian Wang, Yining Wang, Yifan Wang, Jiang Wu, Zhifang Wu, Liming Xia, Jiangxi Xiao, Lei Xu, Youyou Yang, Wu Yin, Jianqun Yu, Li Yuan, Tong Zhang, Longjiang Zhang, Yong-Gao Zhang, Xiaoli Zhang, Li Zhu, Ana Alfaro, Paz Abrihan, Asela Barroso, Eric Cruz, Marie Rhiamar Gomez, Vincent Peter Magboo, John Michael Medina, Jerry Obaldo, Davidson Pastrana, Christian Michael Pawhay, Alvin Quinon, Jeanelle Margareth Tang, Bettina Tecson, Kristine Joy Uson, Mila Uy, Magdalena Kostkiewicz, Jolanta Kunikowska, Nuno Bettencourt, Guilhermina Cantinho, Antonio Ferreira, Ghulam Syed, Samer Arnous, Said Atyani, Angela Byrne, Tadhg Gleeson, David Kerins, Conor Meehan, David Murphy, Mark Murphy, John Murray, Julie O'Brien, Ji-In Bang, Henry Bom, Sang-Geon Cho, Chae Moon Hong, Su Jin Jang, Yong Hyu Jeong, Won Jun Kang, Ji-Young Kim, Jaetae Lee, Chang Kyeong Namgung, Young So, Kyoung Sook Won, Venjamin Majstorov, Marija Vavlukis, Barbara Gužic Salobir, Monika Štalc, Theodora Benedek, Imre Benedek, Raluca Mititelu, Claudiu Adrian Stan, Alexey Ansheles, Olga Dariy, Olga Drozdova, Nina Gagarina, Vsevolod Milyevich Gulyaev, Irina Itskovich, Anatoly Karalkin, Alexander Kokov, Ekaterina Migunova, Viktor Pospelov, Daria Ryzhkova, Guzaliya Saifullina, Svetlana Sazonova, Vladimir Sergienko, Irina Shurupova, Tatjana Trifonova, Wladimir Yurievich Ussov, Margarita Vakhromeeva, Nailya Valiullina, Konstantin Zavadovsky, Kirill Zhuravlev, Mirvat Alasnag, Subhani Okarvi, Dragana Sobic Saranovic, Felix Keng, Jia Hao Jason See, Ramkumar Sekar, Min Sen Yew, Andrej Vondrak, Shereen Bejai, George Bennie, Ria Bester, Gerrit Engelbrecht, Osayande Evbuomwan, Harlem Gongxeka, Magritha Jv Vuuren, Mitchell Kaplan, Purbhoo Khushica, Hoosen Lakhi, Lizette Louw, Nico Malan, Katarina Milos, Moshe Modiselle, Stuart More, Mathava Naidoo, Leonie Scholtz, Mboyo Vangu, Santiago Aguadé-Bruix, Isabel Blanco, Antonio Cabrera, Alicia Camarero, Irene Casáns-Tormo, Hug Cuellar-Calabria, Albert Flotats, Maria Eugenia Fuentes Cañamero, María Elia García, Amelia Jimenez-Heffernan, Rubén Leta, Javier Lopez Diaz, Luis Lumbreras, Juan Javier Marquez-Cabeza, Francisco Martin, Anxo Martinez de Alegria, Francisco Medina, Maria Pedrera Canal, Virginia Peiro, Virginia Pubul-Nuñez, Juan Ignacio Rayo Madrid, Cristina Rodríguez Rey, Ricardo Ruano Perez, Joaquín Ruiz, Gertrudis Sabatel Hernández, Ana Sevilla, Nahla Zeidán, Damayanthi Nanayakkara, Chandraguptha Udugama, Magnus Simonsson, Hatem Alkadhi, Ronny Ralf Buechel, Peter Burger, Luca Ceriani, Bart De Boeck, Christoph Gräni, Alix Juillet de Saint Lager Lucas, Christel H. Kamani, Nadine Kawel-Boehm, Robert Manka, John O. Prior, Axel Rominger, Jean-Paul Vallée, Benjapa Khiewvan, Teerapon Premprabha, Tanyaluck Thientunyakit, Ali Sellem, Kemal Metin Kir, Haluk Sayman, Mugisha Julius Sebikali, Zerida Muyinda, Yaroslav Kmetyuk, Pavlo Korol, Olena Mykhalchenko, Volodymyr Pliatsek, Maryna Satyr, Batool Albalooshi, Mohamed Ismail Ahmed Hassan, Jill Anderson, Punit Bedi, Thomas Biggans, Anda Bularga, Russell Bull, Rajesh Burgul, John-Paul Carpenter, Duncan Coles, David Cusack, Aparna Deshpande, John Dougan, Timothy Fairbairn, Alexia Farrugia, Deepa Gopalan, Alistair Gummow, Prasad Guntur Ramkumar, Mark Hamilton, Mark Harbinson, Thomas Hartley, Benjamin Hudson, Nikhil Joshi, Michael Kay, Andrew Kelion, Azhar Khokhar, Jamie Kitt, Ken Lee, Chen Low, Sze Mun Mak, Ntouskou Marousa, Jon Martin, Elisa Mcalindon, Leon Menezes, Gareth Morgan-Hughes, Alastair Moss, Anthony Murray, Edward Nicol, Dilip Patel, Charles Peebles, Francesca Pugliese, Jonathan Carl Luis Rodrigues, Christopher Rofe, Nikant Sabharwal, Rebecca Schofield, Thomas Semple, Naveen Sharma, Peter Strouhal, Deepak Subedi, William Topping, Katharine Tweed, Jonathan Weir-Mccall, Suhny Abbara, Taimur Abbasi, Brian Abbott, Shady Abohashem, Sandra Abramson, Tarek Al-Abboud, Mouaz Al-Mallah, Omar Almousalli, Karthikeyan Ananthasubramaniam, Mohan Ashok Kumar, Jeffrey Askew, Lea Attanasio, Mallory Balmer-Swain, Richard R. Bayer, Adam Bernheim, Sabha Bhatti, Erik Bieging, Ron Blankstein, Stephen Bloom, Sean Blue, David Bluemke, Andressa Borges, Kelley Branch, Paco Bravo, Jessica Brothers, Matthew Budoff, Renée Bullock-Palmer, Angela Burandt, Floyd W. Burke, Kelvin Bush, Candace Candela, Elizabeth Capasso, Joao Cavalcante, Donald Chang, Saurav Chatterjee, Yiannis Chatzizisis, Michael Cheezum, Tiffany Chen, Jennifer Chen, Marcus Chen, James Clarcq, Ayreen Cordero, Matthew Crim, Sorin Danciu, Bruce Decter, Nimish Dhruva, Neil Doherty, Rami Doukky, Anjori Dunbar, William Duvall, Rachael Edwards, Kerry Esquitin, Husam Farah, Emilio Fentanes, Maros Ferencik, Daniel Fisher, Daniel Fitzpatrick, Cameron Foster, Tony Fuisz, Michael Gannon, Lori Gastner, Myron Gerson, Brian Ghoshhajra, Alan Goldberg, Brian Goldner, Jorge Gonzalez, Rosco Gore, Sandra Gracia-López, Fadi Hage, Agha Haider, Sofia Haider, Yasmin Hamirani, Karen Hassen, Mallory Hatfield, Carolyn Hawkins, Katie Hawthorne, Nicholas Heath, Robert Hendel, Phillip Hernandez, Gregory Hill, Stephen Horgan, Jeff Huffman, Lynne Hurwitz, Ami Iskandrian, Rajesh Janardhanan, Christine Jellis, Scott Jerome, Dinesh Kalra, Summanther Kaviratne, Fernando Kay, Faith Kelly, Omar Khalique, Mona Kinkhabwala, George Kinzfogl Iii, Jacqueline Kircher, Rachael Kirkbride, Michael Kontos, Anupama Kottam, Joseph Krepp, Jay Layer, Steven H. Lee, Jeffrey Leppo, John Lesser, Steve Leung, Howard Lewin, Diana Litmanovich, Yiyan Liu, Kathleen Magurany, Jeremy Markowitz, Amanda Marn, Stephen E. Matis, Michael Mckenna, Tony Mcrae, Fernando Mendoza, Michael Merhige, David Min, Chanan Moffitt, Karen Moncher, Warren Moore, Shamil Morayati, Michael Morris, Mahmud Mossa-Basha, Zorana Mrsic, Venkatesh Murthy, Prashant Nagpal, Kyle Napier, Katarina Nelson, Prabhjot Nijjar, Medhat Osman, Edward Passen, Amit Patel, Pravin Patil, Ryan Paul, Lawrence Phillips, Venkateshwar Polsani, Rajaram Poludasu, Brian Pomerantz, Thomas Porter, Ryan Prentice, Amit Pursnani, Mark Rabbat, Suresh Ramamurti, Florence Rich, Hiram Rivera Luna, Austin Robinson, Kim Robles, Cesar Rodríguez, Mark Rorie, John Rumberger, Raymond Russell, Philip Sabra, Diego Sadler, Mary Schemmer, U. Joseph Schoepf, Samir Shah, Nishant Shah, Sujata Shanbhag, Gaurav Sharma, Steven Shayani, Jamshid Shirani, Pushpa Shivaram, Steven Sigman, Mitch Simon, Ahmad Slim, David Smith, Alexandra Smith, Prem Soman, Aditya Sood, Monvadi Barbara Srichai-Parsia, James Streeter, Albert T, Ahmed Tawakol, Dustin Thomas, Randall Thompson, Tara Torbet, Desiree Trinidad, Shawn Ullery, Samuel Unzek, Seth Uretsky, Srikanth Vallurupalli, Vikas Verma, Alfonso Waller, Ellen Wang, Parker Ward, Gaby Weissman, George Wesbey, Kelly White, David Winchester, David Wolinsky, Sandra Yost, Michael Zgaljardic, Omar Alonso, Mario Beretta, Rodolfo Ferrando, Miguel Kapitan, Fernando Mut, Omoa Djuraev, Gulnora Rozikhodjaeva, Ha Le Ngoc, Son Hong Mai, and Xuan Canh Nguyen

Subjects
cardiac testing, cardiovascular disease, coronavirus, COVID-19, global health, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known. Objectives: This study sought to evaluate the effects of the early phase of the COVID-19 pandemic on cardiovascular diagnostic procedures and safety practices in Asia. Methods: The International Atomic Energy Agency conducted a worldwide survey to assess changes in cardiovascular procedure volume and safety practices caused by COVID-19. Testing volumes were reported for March 2020 and April 2020 and were compared to those from March 2019. Data from 180 centers across 33 Asian countries were grouped into 4 subregions for comparison. Results: Procedure volumes decreased by 47% from March 2019 to March 2020, showing recovery from March 2020 to April 2020 in Eastern Asia, particularly in China. The majority of centers cancelled outpatient activities and increased time per study. Practice changes included implementing physical distancing and restricting visitors. Although COVID testing was not commonly performed, it was conducted in one-third of facilities in Eastern Asia. The most severe reductions in procedure volumes were observed in lower-income countries, where volumes decreased 81% from March 2019 to April 2020. Conclusions: The COVID-19 pandemic in Asia caused significant reductions in cardiovascular diagnostic procedures, particularly in low-income countries. Further studies on effects of COVID-19 on cardiovascular outcomes and changes in care delivery are warranted.

Published
2021
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46. Meta-analysis of the efficacy of preoperative skin preparation with alcoholic chlorhexidine compared to povidone iodine in orthopedic surgery

Author

Mario Mastrocola, Georg Matziolis, Sabrina Böhle, Chris Lindemann, Peter Schlattmann, and Henk Eijer

Subjects
Medicine, Science
Abstract

Abstract Preoperative skin preparation is an effective method to prevent surgical site infections (SSI). Alcoholic chlorhexidine (CHG) and povidone iodine (PV-I) are the most widely used antiseptic agents. This meta-analysis aims to determine their efficacy in reducing natural bacterial skin flora in clean orthopedic surgery. A systematic search was conducted through current literature up to June 2021 to identify clinical randomized trials that compared the efficacy of alcoholic chlorhexidine and povidone iodine in reducing bacterial skin colonization after preoperative skin preparation. A meta-analysis was conducted. Of 235 screened articles, 8 randomized controlled trials were included. The results of the meta-analysis demonstrate a significantly lower positive culture rate in the chlorhexidine group than in the povidone iodine group (RR = 0.53, 95% Cl: 0.32–0.88). The present data show the superiority of chlorhexidine in reducing the normal bacterial flora compared to povidone iodine in clean orthopedic surgery.

Published
2021
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48. Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia: The IAEA INCAPS-COVID Study

Author

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Published
2021
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50. ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis

Author

Gustavo Ferreira Alves, Ian Stoppa, Eleonora Aimaretti, Chiara Monge, Raffaella Mastrocola, Elisa Porchietto, Giacomo Einaudi, Debora Collotta, Ilaria Bertocchi, Elena Boggio, Casimiro Luca Gigliotti, Nausicaa Clemente, Manuela Aragno, Daniel Fernandes, Carlo Cifani, Christoph Thiemermann, Chiara Dianzani, Umberto Dianzani, and Massimo Collino

Subjects
sepsis, inflammation, ICOS (inducible co-stimulatory molecule), cecal ligation and puncture, osteopontin (OPN), Immunologic diseases. Allergy, RC581-607
Abstract

Inducible T cell co-stimulator (ICOS), an immune checkpoint protein expressed on activated T cells and its unique ligand, ICOSL, which is expressed on antigen-presenting cells and non-hematopoietic cells, have been extensively investigated in the immune response. Recent findings showed that a soluble recombinant form of ICOS (ICOS-Fc) can act as an innovative immunomodulatory drug as both antagonist of ICOS and agonist of ICOSL, modulating cytokine release and cell migration to inflamed tissues. Although the ICOS-ICOSL pathway has been poorly investigated in the septic context, a few studies have reported that septic patients have reduced ICOS expression in whole blood and increased serum levels of osteopontin (OPN), that is another ligand of ICOSL. Thus, we investigated the pathological role of the ICOS-ICOSL axis in the context of sepsis and the potential protective effects of its immunomodulation by administering ICOS-Fc in a murine model of sepsis. Polymicrobial sepsis was induced by cecal ligation and puncture (CLP) in five-month-old male wild-type (WT) C57BL/6, ICOS-/-, ICOSL-/- and OPN-/- mice. One hour after the surgical procedure, either CLP or Sham (control) mice were randomly assigned to receive once ICOS-Fc, F119SICOS-Fc, a mutated form uncapable to bind ICOSL, or vehicle intravenously. Organs and plasma were collected 24 h after surgery for analyses. When compared to Sham mice, WT mice that underwent CLP developed within 24 h a higher clinical severity score, a reduced body temperature, an increase in plasma cytokines (TNF-α, IL-1β, IL-6, IFN-γ and IL-10), liver injury (AST and ALT) and kidney (creatinine and urea) dysfunction. Administration of ICOS-Fc to WT CLP mice reduced all of these abnormalities caused by sepsis. Similar beneficial effects were not seen in CLP-mice treated with F119SICOS-Fc. Treatment of CLP-mice with ICOS-Fc also attenuated the sepsis-induced local activation of FAK, P38 MAPK and NLRP3 inflammasome. ICOS-Fc seemed to act at both sides of the ICOS-ICOSL interaction, as the protective effect was lost in septic knockout mice for the ICOS or ICOSL genes, whereas it was maintained in OPN knockout mice. Collectively, our data show the beneficial effects of pharmacological modulation of the ICOS-ICOSL pathway in counteracting the sepsis-induced inflammation and organ dysfunction.

Published
2022
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