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3. Sex and the Risk of Atheromatous and Nonatheromatous Cardiovascular Disease in CKD: Findings From the CKD-REIN Cohort Study

Author

Alencar de Pinho, Natalia, Cannet, Dorothée, Fouque, Denis, Frimat, Luc, Hamroun, Aghiles, Herpe, Yves-Edouard, Jacquelinet, Christian, Lambert, Oriane, Lange, Céline, Laville, Maurice, Liabeuf, Sophie, Massy, Ziad A., Metzger, Marie, Morel, Pascal, Pascal, Christophe, Pecoits-Filho, Roberto, Stengel, Bénédicte, Azar, Raymond, Belenfant, Xavier, Besnier, Dominique, Bourdenx, Jean Philippe, Burtey, Stéphane, Chauveau, Dominique, Chazot, Charles, Choukroun, Gabriel, Combe, Christian, Delahousse, Michel, Deroure, Benjamin, Essig, Marie, Glowacki, François, Hannedouche, Thierry, Hoffmann, Maxime, Hourmant, Maryvonne, Jamali, Mohamed, Juillard, Laurent, Kamar, Nassim, Keller, Adrien, Klein, Alexandre, Kuentz, François, Lacraz, Adeline, Lambrey, Guy, Landru, Isabelle, Lang, Philippe, Lebrun, Gaetan, Lobbedez, Thierry, Magnant, Eric, Mailliez, Sébastien, Maisonneuve, Nathalie, Martin, Séverine, Moulin, Bruno, Noel, Christian, Panescu, Viktor, Sekhri, Hacène, Smati, Mustafa, Testa, Angelo, Thervet, Eric, Urena, Pablo, Vela, Carlos, Zaoui, Philippe, Faucon, Anne-Laure, Massy, Ziad, Drüeke, Tilman B., Hauguel-Moreau, Marie, and Mansencal, Nicolas

Published
2024
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6. Kidney Function Decline and Serious Adverse Drug Reactions in Patients With CKD

Author

Ayav, Carole, Briançon, Serge, Cannet, Dorothée, Combe, Christian, Fouque, Denis, Frimat, Luc, Herpe, Yves-Edouard, Jacquelinet, Christian, Laville, Maurice, Massy, Ziad A., Pascal, Christophe, Robinson, Bruce M., Stengel, Bénédicte, Lange, Céline, Legrand, Karine, Liabeuf, Sophie, Metzger, Marie, Speyer, Elodie, Hannedouche, Thierry, Moulin, Bruno, Mailliez, Sébastien, Lebrun, Gaétan, Magnant, Eric, Choukroun, Gabriel, Deroure, Benjamin, Lacraz, Adeline, Lambrey, Guy, Philippe, Jean, Bourdenx, Essig, Marie, Lobbedez, Thierry, Azar, Raymond, Sekhri, Hacène, Smati, Mustafa, Jamali, Mohamed, Klein, Alexandre, Delahousse, Michel, Martin, Séverine, Landru, Isabelle, Thervet, Eric, Lang, Philippe, Belenfant, Xavier, Urena, Pablo, Vela, Carlos, Chauveau, Dominique, Panescu, Viktor, Noel, Christian, Glowacki, François, Hoffmann, Maxime, Hourmant, Maryvonne, Besnier, Dominique, Testa, Angelo, Kuentz, François, Zaoui, Philippe, Chazot, Charles, Juillard, Laurent, Burtey, Stéphane, Keller, Adrien, Kamar, Nassim, Laville, Solène M., Gras-Champel, Valérie, Hamroun, Aghilès, Moragny, Julien, Lambert, Oriane, Bieber, Brian, and Alencar De Pinho, Natalia

Published
2024
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10. CKD-Associated Pruritus and Clinical Outcomes in Nondialysis CKD

Author

Lopes, Antonio, Pecoits-Filho, Roberto, Combe, Christian, Jacquelinet, Christian, Massy, Ziad, Stengel, Benedicte, Duttlinger, Johannes, Fliser, Danilo, Lonnemann, Gerhard, Reichel, Helmut, Wada, Takashi, Yamagata, Kunihiro, Pisoni, Ron, Robinson, Bruce, Calice da Silva, Viviane, Sesso, Ricardo, Speyer, Elodie, Asahi, Koichi, Hoshino, Junichi, Narita, Ichiei, Perlman, Rachel, Port, Friedrich, Sukul, Nidhi, Wong, Michelle, Young, Eric, Zee, Jarcy, Scherer, Jennifer S., Tu, Charlotte, Pisoni, Ronald L., Lopes, Antonio A., Wen, Warren, Menzaghi, Frederique, Cirulli, Joshua, Alencar de Pinho, Natalia, and Karaboyas, Angelo

Published
2024
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11. Machine Learning-Based Urine Peptidome Analysis to Predict and Understand Mechanisms of Progression to Kidney Failure

Author

ALENCAR DE PINHO, Natalia, AYAV, Carole, CANNET, Dorothée, COMBE, Christian, DELEUZE, Jean-François, FOUQUE, Denis, FRIMAT, Luc, HERPE, Yves-Edouard, JACQUELINET, Christian, LAVILLE, Maurice, LIABEUF, Sophie, MASSY, Ziad A., PASCAL, Christophe, ROBINSON, Bruce, PECOITS-FILHO, Roberto, SCHANSTRA, Joost, STENGEL, Bénédicte, LANGE, Céline, METZGER, Marie, SPEYER, Elodie, Massy, Ziad A., Lambert, Oriane, Metzger, Marie, Sedki, Mohammed, Chaubet, Adeline, Breuil, Benjamin, Jaafar, Acil, Tack, Ivan, Nguyen-Khoa, Thao, Alves, Melinda, Siwy, Justyna, Mischak, Harald, Verbeke, Francis, Glorieux, Griet, Herpe, Yves-Edouard, Schanstra, Joost P., Stengel, Bénédicte, and Klein, Julie

Published
2023
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14. Adherence to the Kidney Disease: Improving Global Outcomes CKD Guideline in Nephrology Practice Across Countries

Author

Lopes, Antonio, Pecoits-Filho, Roberto, Combe, Christian, Jacquelinet, Christian, Massy, Ziad, Stengel, Bénédicte, Duttlinger, Johannes, Fliser, Danilo, Lonnemann, Gerhard, Reichel, Helmut, Wada, Takashi, Yamagata, Kunihiro, Pisoni, Ron, Robinson, Bruce, Calice da Silva, Viviane, Sesso, Ricardo, Speyer, Elodie, Asahi, Koichi, Hoshino, Junichi, Narita, Ichiei, Perlman, Rachel, Port, Friedrich, Sukul, Nidhi, Wong, Michelle, Young, Eric, Zee, Jarcy, Muenz, Daniel, Tu, Charlotte, Alencar de Pinho, Natalia, Massy, Ziad A., Lopes, Antonio A., Jadoul, Michel, Winkelmayer, Wolfgang C., Pisoni, Ronald L., and Robinson, Bruce M.

Published
2021
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16. #2379 Acute kidney injury as a key predictor of major adverse cardiovascular events in chronic kidney disease patients

Author

Florens, Nans, primary, Aymes, Estelle, additional, Gauthier, Victoria, additional, Frimat, Luc, additional, Laville, Maurice, additional, Amouyel, Philippe, additional, Nicolas, Mansencal, additional, Liabeuf, Sophie, additional, Massy, Ziad, additional, Stengel, Benedicte, additional, de Pinho, Natalia Alencar, additional, and Hamroun, Aghiles, additional

Published
2024
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17. #1135 Evaluation of the adequacy of urate lowering therapy prescriptions in patients with chronic kidney disease: results from the CKD-REIN cohort

Author

Mouheb, Agathe, primary, Lambert, Oriane, additional, de Pinho, Natalia Alencar, additional, Jacquelinet, Christian, additional, Laville, Maurice, additional, Combe, Christian, additional, Fouque, Denis, additional, Frimat, Luc, additional, Stengel, Benedicte, additional, Massy, Ziad, additional, Laville, Solene M, additional, and Liabeuf, Sophie, additional

Published
2024
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20. #1091 Quantifying the potential contribution of drugs to the occurrence of acute kidney injury in patients with chronic kidney disease

Author

Liabeuf, Sophie, primary, Massy, Ziad, additional, Gras-Champel, Valérie, additional, Frimat, Luc, additional, Laville, Maurice, additional, Jacquelinet, Christian, additional, Pecoits-Filho, Roberto, additional, de Pinho, Natalia Alencar, additional, Hamroun, Aghilès, additional, and Laville, Solene M, additional

Published
2024
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22. Long-term health-related quality of life outcomes of adults with pediatric onset of frequently relapsing or steroid-dependent nephrotic syndrome

Author

Meuleman, Marie-Sophie, Guilmin-Crépon, Sophie, Hummel, Aurélie, Daugas, Eric, Dumas, Agnès, Leye, Fallou, Dantal, Jacques, Rigothier, Claire, Provot, François, Chauveau, Dominique, Burtey, Stéphane, Hertig, Alexandre, Dahan, Karine, Durrbach, Antoine, Dossier, Claire, Karras, Alexandre, Guerrot, Dominique, Esnault, Vincent, Rémy, Philippe, Massy, Ziad A., Tostivint, Isabelle, Morin, Marie-Pascale, Zaoui, Philippe, Fritz, Olivier, Le Quintrec, Moglie, Wynckel, Alain, Bourmaud, Aurélie, Boyer, Olivia, Sahali, Dil, Alberti, Corinne, Audard, Vincent, and Mellerio, Hélène

Published
2022
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23. The association between TMAO, CMPF, and clinical outcomes in advanced chronic kidney disease: results from the European QUALity (EQUAL) Study

Author

Dai, Lu, Massy, Ziad A, Stenvinkel, Peter, Chesnaye, Nicholas C, Larabi, Islam Amine, Alvarez, Jean Claude, Caskey, Fergus J, Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Krajewska, Magdalena, Drechsler, Christiane, Wanner, Christoph, Jager, Kitty J, Dekker, Friedo W, Evenepoel, Pieter, and Evans, Marie

Published
2022
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24. Prediction of chronic kidney disease after acute kidney injury in ICU patients: study protocol for the PREDICT multicenter prospective observational study

Author

Geri, Guillaume, Stengel, Bénédicte, Jacquelinet, Christian, Aegerter, Philippe, Massy, Ziad A, Vieillard-Baron, Antoine, and the PREDICT investigators

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Patient Safety, Clinical Research, Kidney Disease, Renal and urogenital, Good Health and Well Being, PREDICT investigators, Acute kidney injury, Chronic kidney disease, End-stage renal disease, Intensive care unit, Public Health and Health Services, Clinical sciences
Abstract

BackgroundAcute kidney injury (AKI) is frequent and associated with poor outcome in intensive care unit (ICU) patients. Besides the association with short- and long-term mortality, the increased risk of chronic kidney disease (CKD) has been recently highlighted in non-ICU patients. This study aims to describe the incidence and determinants of CKD after AKI and to develop a prediction score for CKD in ICU patients.MethodsProspective multicenter (n = 17) observational study included 1200 ICU patients who suffered from AKI (defined by an AKIN stage ≥ 1) during their ICU stay and were discharged alive from ICU. Preexisting end-stage renal disease (ESRD) and immunosuppressant treatments are the main exclusion criteria. Patients will be monitored by a nephrologist at day 90 and every year for 3 years. The main outcome is the occurrence of CKD defined by a creatinine-based estimated glomerular filtration rate (eGFR) lower than 60 mL/min/1.73 m2 or renal replacement therapy for ESRD in patients whose eGFR will be normalized (≥ 60 mL/min/1.73 m2) at day 90. Secondary outcomes include albuminuria changes, eGFR decline slope and ESRD risk in patients with preexisting CKD, cardiovascular and thromboembolic events and health-related quality of life.DiscussionThis is the first study prospectively investigating kidney function evolution in ICU patients who suffered from AKI. Albuminuria and eGFR monitoring will allow to identify ICU patients at risk of CKD who may benefit from close surveillance after recovering from AKI. Major patient and AKI-related determinants will be tested to develop a prediction score for CKD in this population. Trial registration ClinicalTrials.gov, NCT03282409. Registered on September 14, 2017.

Published
2018

25. Effectiveness and Tolerance of Renin-Angiotensin System Inhibitors With Aging in Chronic Kidney Disease

Author

Ayav, Carole, Briançon, Serge, Cannet, Dorothée, Combe, Christian, Fouque, Denis, Frimat, Luc, Herpe, Yves-Edouard, Jacquelinet, Christian, Laville, Maurice, Massy, Ziad A., Pascal, Christophe, Robinson, Bruce M., Stengel, Bénédicte, Lange, Céline, Legrand, Karine, Liabeuf, Sophie, Metzger, Marie, Speyer, Elodie, Hannedouche, Thierry, Moulin, Bruno, Mailliez, Sébastien, Lebrun, Gaétan, Magnant, Eric, Choukroun, Gabriel, Deroure, Benjamin, Lacraz, Adeline, Lambrey, Guy, Bourdenx, Jean Philippe, Essig, Marie, Lobbedez, Thierry, Azar, Raymond, Sekhri, Hacène, Smati, Mustafa, Jamali, Mohamed, Klein, Alexandre, Delahousse, Michel, Martin, Séverine, Landru, Isabelle, Thervet, Eric, Lang, Philippe, Belenfant, Xavier, Urena, Pablo, Vela, Carlos, Chauveau, Dominique, Panescu, Viktor, Noel, Christian, Glowacki, François, Hoffmann, Maxime, Hourmant, Maryvonne, Besnier, Dominique, Testa, Angelo, Kuentz, François, Zaoui, Philippe, Chazot, Charles, Juillard, Laurent, Burtey, Stéphane, Keller, Adrien, Kamar, Nassim, Villain, Cédric, Hamroun, Aghilès, Laville, Solene, Mansencal, Nicolas, and Pecoits-Filho, Roberto

Published
2022
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26. Potential Surrogate Outcomes for Kidney Failure in Advanced CKD: Evaluation of Power and Predictive Ability in CKDopps

Author

Combe, Christian, Duttlinger, Johannes, Fliser, Danilo, Jacquelinet, Christian, Lonnemann, Gerhard, Lopes, Antonio, Massy, Ziad, Pecoits-Filho, Roberto, Reichel, Helmut, Stengel, Bénédicte, Wada, Takashi, Yamagata, Kunihiro, Zee, Jarcy, Muenz, Daniel, McCullough, Keith P., Bieber, Brian, Metzger, Marie, Alencar de Pinho, Natalia, Lopes, Antonio A., Robinson, Bruce M., Young, Eric, and Pisoni, Ronald L.

Published
2022
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27. Prévalence de la maladie rénale chronique à Antananarivo, Madagascar

Author

Ranivoharisoa, Éliane Mikkelsen, Randriamahazo, Toky Rakotomalala, Raherinandrasana, Antso Hasina, Ramilitiana, Benja, Salohimanana, Randrianarisoa Aina, Rabarijaona, Mamy, Andriamifidison, Rodolphe, Cormerais, Claude, Godin, Franck, Rakotonirina, Julio, Cân, Nhân Luong, Quillard, Michel, Randriamarotia, Franck Willy Harilalaina, and Massy, Ziad A.

Published
2022
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28. Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease.

Author

Liabeuf, Sophie, Hafez, Gaye, Pešić, Vesna, Spasovski, Goce, Bobot, Mickaël, Mačiulaitis, Romaldas, Bumblyte, Inga Arune, Ferreira, Ana Carina, Farinha, Ana, Malyszko, Jolanta, Pépin, Marion, Massy, Ziad A, Unwin, Robert, Capasso, Giovambattista, Mani, Laila-Yasmin, and Target), CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative

Abstract

The relationship between chronic kidney disease (CKD) and cognitive function has received increased attention in recent years. Antibacterial agents (ABs) represent a critical component of therapy regimens in patients with CKD due to increased susceptibility to infections. Following our reviewing work on the neurocognitive impact of long-term medications in patients with CKD, we propose to focus on AB-induced direct and indirect consequences on cognitive function. Patients with CKD are predisposed to adverse drug reactions (ADRs) due to altered drug pharmacokinetics, glomerular filtration decline, and the potential disruption of the blood–brain barrier. ABs have been identified as a major cause of ADRs in vulnerable patient populations. This review examines the direct neurotoxic effects of AB classes (e.g. beta-lactams, fluoroquinolones, aminoglycosides, and metronidazole) on the central nervous system (CNS) in patients with CKD. We will mainly focus on the acute effects on the CNS associated with AB since they are the most extensively studied effects in CKD patients. Moreover, the review describes the modulation of the gut microbiota by ABs, potentially influencing CNS symptoms. The intricate brain–gut–kidney axis emerges as a pivotal focus, revealing the interplay between microbiota alterations induced by ABs and CNS manifestations in patients with CKD. The prevalence of antibiotic-associated encephalopathy in patients with CKD undergoing intravenous AB therapy supports the use of therapeutic drug monitoring for ABs to reduce the number and seriousness of ADRs in this patient population. In conclusion, elucidating AB-induced cognitive effects in patients with CKD demands a comprehensive understanding and tailored therapeutic strategies that account for altered pharmacokinetics and the brain–gut–kidney axis. [ABSTRACT FROM AUTHOR]

Published
2024
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29. De-indexed estimated glomerular filtration rates for the dosing of oral antidiabetic drugs in patients with chronic kidney disease.

Author

Pluquet, Maxime, Metzger, Marie, Jacquelinet, Christian, Combe, Christian, Fouque, Denis, Laville, Maurice, Frimat, Luc, Massy, Ziad A., Liabeuf, Sophie, and Laville, Solène M.

Subjects
CHRONIC kidney failure, GLOMERULAR filtration rate, ORAL medication, CHRONICALLY ill, INAPPROPRIATE prescribing (Medicine), METFORMIN, SITAGLIPTIN, INFANT formulas
Abstract

Introduction: Adjusting drug dose levels based on equations that standardize the estimated glomerular filtration rate (eGFR) to a body surface area (BSA) of 1.73m2 can pose challenges, especially for patients with extremely high or low body mass index (BMI). The objective of the present study of patients with CKD and diabetes was to assess the impact of deindexing creatinine-based equations on estimates of kidney function and on the frequency of inappropriate prescriptions of oral antidiabetic drugs (OADs). Methods: The prospective CKD-REIN cohort is comprised of patients with eGFR <60 mL/min/1.73m². The inclusion criteria for this study were the use of OADs and the availability of data on weight, height and serum creatinine. We compared data for three BMI subgroups (group 1 <30 kg/m²; group 2 30-34.9 kg/m²; group 3 =35 kg/m²). Inappropriate prescriptions (contraindicated or over-dosed drugs) were assessed with regard to the summary of product characteristics and the patient's kidney function estimated with the 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, the 2021 CKD-EPI equation, the Modification of Diet in Renal Disease (MDRD) equation, the European Kidney Function Consortium (EKFC) equation, their deindexed estimates, and the Cockcroft-Gault (CG) formula. The impact of deindexing the equations was evaluated by assessing 1) the difference between the indexed and deindexed eGFRs, and 2) the difference in the proportion of patients with at least one inappropriate OAD prescription between the indexed and deindexed estimates. Results: At baseline, 694 patients were receiving OADs. The median BMI was 30.7 kg/m², the mean BSA was 1.98m², and 90% of patients had a BSA >1.73m². Deindexing the kidney function estimates led to higher eGFRs, especially in BMI group 3. The proportion of patients with at least one inappropriate prescription differed greatly when comparing indexed and deindexed estimates. The magnitude of the difference increased with the BMI: when comparing BMI group 1 with BMI group 3, the difference was respectively -4% and -10% between deindexed 2021 CKD-EPI and indexed CKD-EPI. Metformin and sitagliptin were the most frequent inappropriately prescribed OADs. Conclusion: We highlight significant differences between the BSA-indexed and deindexed versions of equations used to estimate kidney function, emphasizing the importance of using deindexed estimates to adjust drug dose levels - especially in patients with an extreme BMI. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Urea Level and Depression in Patients with Chronic Kidney Disease.

Author

Levassort, Hélène, Boucquemont, Julie, Lambert, Oriane, Liabeuf, Sophie, Laville, Solene M., Teillet, Laurent, Tabcheh, Abdel-Hay, Frimat, Luc, Combe, Christian, Fouque, Denis, Laville, Maurice, Jacquelinet, Christian, Helmer, Catherine, Alencar de Pinho, Natalia, Pépin, Marion, and Massy, Ziad A.

Subjects
CHRONIC kidney failure, SYMPTOM burden, MENTAL depression, CHRONICALLY ill, KIDNEY diseases
Abstract

Depression is common in patients with chronic kidney disease (CKD). Experimental studies suggest the role of urea toxicity in depression. We assessed both the incidence of antidepressant prescriptions and depressive symptoms (measured by CESD (Center for Epidemiologic Depression) scale) in 2505 patients with CKD (Stage 3–4) followed up over 5 years in the Chronic Kidney Disease Renal Epidemiology and Information Network (CKD-REIN) cohort. We used a joint model to assess the association between the serum urea level and incident antidepressant prescriptions, and mixed models for the association between the baseline serum urea level and CESD score over the 5-year follow-up. Among the 2505 patients, 2331 were not taking antidepressants at baseline. Of the latter, 87 started taking one during a median follow-up of 4.6 years. After adjustment for confounding factors, the hazard ratio for incident antidepressant prescription associated with the serum urea level (1.28 [95%CI, 0.94,1.73] per 5 mmol/L increment) was not significant. After adjustment, the serum urea level was associated with the mean change in the CESD score (β = 0.26, [95%CI, 0.11,0.41] per 5 mmol/L increment). Depressive symptoms burden was associated with serum urea level unlike depression events. Further studies are needed to draw firm conclusions and better understand the mechanisms of depression in CKD. [ABSTRACT FROM AUTHOR]

Published
2024
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32. List of contributors

Author

Adamczak, Marcin, primary, Amabile, Maria Ida, additional, Apata, Ibironke W., additional, Apetrii, Mugurel, additional, Avesani, Carla Maria, additional, Bahner, Udo, additional, Bailey, James L., additional, Bansal, Anip, additional, Barba, Christophe, additional, Bellorin-Font, Ezequiel, additional, Bross, Rachelle, additional, Brown-Tortorici, Amanda, additional, Burnier, Michel, additional, Burrowes, Jerrilynn Denise, additional, Carrero, Juan Jesús, additional, Cervantes, MacKenzie K., additional, Chadban, Steven, additional, Chadha, Vimal, additional, Chan, Maria, additional, Chan, Winnie, additional, Chazot, Charles, additional, Chiang, Janet M., additional, Chonchol, Michel, additional, Chwastiak, Lydia, additional, Covic, Adrian, additional, Cuppari, Lilian, additional, Dahl, Neera K., additional, Di Iorio, Biagio, additional, Di Mario, Francesca, additional, Druml, Wilfred, additional, Dukkipati, Ramanath, additional, Fazeli, Gholamreza, additional, Fiaccadori, Enrico, additional, Finkelstein, Fredric, additional, Fouque, Denis, additional, Franch, Harold A., additional, Friedman, Allon N., additional, Garimella, Pranav S., additional, Glassock, Richard J., additional, Goldfarb, David S., additional, González-Ortiz, Ailema, additional, Goraya, Nimrit, additional, Gutiérrez, Orlando M., additional, Hanafusa, Norio, additional, Heidland, August, additional, Heimbürger, Olof, additional, Hirschberg, Raimund, additional, Ikizler, T. Alp, additional, Johansen, Kirsten, additional, Johnson, Richard J., additional, Joshi, Shivam, additional, Kalantar-Zadeh, Kamyar, additional, Kang, Duk-Hee, additional, Kaysen, George A., additional, Kim, Jun-Chul, additional, Kistler, Brandon, additional, Koppe, Laetitia, additional, Kopple, Joel D., additional, Kovesdy, Csaba P., additional, Kramer, Holly J., additional, Kurokawa, Kiyoshi, additional, Lindholm, Bengt, additional, Martin, Kevin J., additional, Martino, Steve, additional, Marzocco, Stefania, additional, Massry, Shaul G., additional, Massy, Ziad A., additional, Mitch, William E., additional, Miyata, Toshio, additional, Molfino, Alessio, additional, Moradi, Hamid, additional, Nakagawa, Takahiko, additional, Narasaki, Yoko, additional, Puzziferri, Nancy, additional, Quinn, Noel, additional, Raj, Dominic S., additional, Raphael, Kalani L., additional, Regunathan-Shenk, Renu, additional, Rhee, Connie M., additional, Ritz, Eberhard, additional, Sabatino, Alice, additional, Sarnak, Mark J., additional, Scialla, Julia, additional, Seefried, Lothar, additional, Sellinger, John, additional, Shah, Anuja, additional, Shah, Neal B., additional, Shah, Sudhir V., additional, Singh, Manisha, additional, Spatola, Leonardo, additional, Stanton, Robert C., additional, Steiber, Alison L., additional, Stenvinkel, Peter, additional, St-Jules, David E., additional, Storer, Thomas W., additional, Sumida, Keiichi, additional, Sussman-Dabach, Elizabeth J., additional, Swaminathan, Sundararaman, additional, Sy, John, additional, Tantisattamo, Ekamol, additional, Vaziri, Nosratola D., additional, Voinescu, Alexandra, additional, Wang, Angela Yee-Moon, additional, Warady, Bradley A., additional, Weiner, Daniel E., additional, Wesson, Donald E., additional, Wiecek, Andrzej, additional, Williams, Mark E., additional, Wolfe, Bruce M., additional, Workeneh, Biruh T., additional, and Zhao, Ying-Yong, additional

Published
2022
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34. A randomized multicenter trial on a lung ultrasound–guided treatment strategy in patients on chronic hemodialysis with high cardiovascular risk

Author

Zoccali, Carmine, Torino, Claudia, Mallamaci, Francesca, Sarafidis, Pantelis, Papagianni, Aikaterini, Ekart, Robert, Hojs, Radovan, Klinger, Marian, Letachowicz, Krzysztof, Fliser, Danilo, Seiler-Mußler, Sarah, Lizzi, Fabio, Wiecek, Andrzej, Miskiewicz, Agata, Siamopoulos, Kostas, Balafa, Olga, Slotki, Itzchak, Shavit, Linda, Stavroulopoulos, Aristeidis, Covic, Adrian, Siriopol, Dimitrie, Massy, Ziad A., Seidowsky, Alexandre, Battaglia, Yuri, Martinez-Castelao, Alberto, Polo-Torcal, Carolina, Coudert-Krier, Marie-Jeanne, Rossignol, Patrick, Fiaccadori, Enrico, Regolisti, Giuseppe, Hannedouche, Thierry, Bachelet, Thomas, Jager, Kitty J., Dekker, Friedo W., Tripepi, Rocco, Tripepi, Giovanni, Gargani, Luna, Sicari, Rosa, Picano, Eugenio, and London, Gérard Michel

Published
2021
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35. The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The CKD‐REIN cohort study

Author

Bonnet, Fabrice, primary, Balkau, Beverley, additional, Lambert, Oriane, additional, Diawara, Yakhara, additional, Combe, Christian, additional, Frimat, Luc, additional, Laville, Maurice, additional, Liabeuf, Sophie, additional, Massy, Ziad A., additional, Metzger, Marie, additional, Stengel, Bénédicte, additional, Alencar de Pinho, Natalia, additional, and Fouque, Denis, additional

Published
2024
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36. Risk of Kidney Failure and Mortality in Patients Under Nephrology Care in NonHigh-Income Settings

Author

Guedes, Murilo, primary, Tu, Charlotte, additional, Bieber, Brian, additional, Silva, Viviane Calice, additional, Lopes, Antonio, additional, Sesso, Ricardo, additional, De Pinho, Natalia Alencar, additional, Pecoits-Filho, Roberto, additional, Combe, Christian, additional, Jacquelinet, Christian, additional, Massy, Ziad, additional, Stengel, Benedicte, additional, Duttlinger, Johannes, additional, Fliser, Danilo, additional, Lonnemann, Gerhard, additional, Reichel, Helmut, additional, Wada, Takashi, additional, Yamagata, Kunihiro, additional, Pisoni, Ron, additional, Robinson, Bruce, additional, Calice da Silva, Viviane, additional, Speyer, Elodie, additional, Asahi, Koichi, additional, Hoshino, Junichi, additional, Narita, Ichiei, additional, Perlman, Rachel, additional, Port, Friedrich, additional, Sukul, Nidhi, additional, Wong, Michelle, additional, Young, Eric, additional, and Zee, Jarcy, additional

Published
2024
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38. Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe

Author

Stel, Vianda S., de Jong, Rianne W., Kramer, Anneke, Andrusev, Anton M., Baltar, José M., Barbullushi, Myftar, Bell, Samira, Castro de la Nuez, Pablo, Cernevskis, Harijs, Couchoud, Cécile, De Meester, Johan, Eriksen, Bjørn O., Gârneaţă, Liliana, Golan, Eliezer, Helve, Jaakko, Hemmelder, Marc H., Hommel, Kristine, Ioannou, Kyriakos, Jarraya, Faiçal, Kantaria, Nino, Kerschbaum, Julia, Komissarov, Kirill S., Magaz, Ángela, Mercadal, Lucile, Ots-Rosenberg, Mai, Pálsson, Runólfur, Rahmel, Axel, Rydell, Helena, Savino, Manuela, Seyahi, Nurhan, Slon Roblero, Maria F., Stojceva-Taneva, Olivera, van der Tol, Arjan, Vazelov, Evgueniy S., Ziginskiene, Edita, Zurriaga, Óscar, Vanholder, Raymond C., Massy, Ziad A., and Jager, Kitty J.

Published
2021
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40. Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

Author

Abu-Alfa, Ali K., Afsar, Baris, Pai, Amy Barton, Besarab, Anatole, Moore, Geraldine Biddle, Casadevall, Nicole, Cases, Aleix, de Francisco, Angel, Eckardt, Kai-Uwe, Fishbane, Steven, Fried, Linda F., Ganz, Tomas, Ginzburg, Yelena Z., Gómez, Rafael, Goodnough, Lawrence T., Hamano, Takayuki, Hanudel, Mark R., Hao, Chuan-Ming, Iseki, Kunitoshi, Ix, Joachim H., Johansen, Kirsten L., Ketteler, Markus, Kovesdy, Csaba P., Leaf, David E., Macdougall, Iain C., Massy, Ziad A., McMahon, Lawrence P., Minutolo, Roberto, Nakanishi, Takeshi, Nemeth, Elizabeta, Obrador, Gregorio T., Parfrey, Patrick S., Park, Hyeong-Cheon, Pecoits-Filho, Roberto, Robinson, Bruce M., Roger, Simon D., Shah, Yatrik M., Spinowitz, Bruce S., Tanaka, Tetsuhiro, Tsukamoto, Yusuke, Tungsanga, Kriang, Walther, Carl P., Yee-Moon Wang, Angela, Wolf, Myles, Babitt, Jodie L., Eisenga, Michele F., Haase, Volker H., Kshirsagar, Abhijit V., Levin, Adeera, Locatelli, Francesco, Małyszko, Jolanta, Swinkels, Dorine W., Tarng, Der-Cherng, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., and Drüeke, Tilman B.

Published
2021
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44. Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe

Author

Jager, Kitty J., Kramer, Anneke, Chesnaye, Nicholas C., Couchoud, Cécile, Sánchez-Álvarez, J. Emilio, Garneata, Liliana, Collart, Fréderic, Hemmelder, Marc H., Ambühl, Patrice, Kerschbaum, Julia, Legeai, Camille, del Pino y Pino, María Dolores, Mircescu, Gabriel, Mazzoleni, Lionel, Hoekstra, Tiny, Winzeler, Rebecca, Mayer, Gert, Stel, Vianda S., Wanner, Christoph, Zoccali, Carmine, and Massy, Ziad A.

Published
2020
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45. Data from the ERA-EDTA Registry were examined for trends in excess mortality in European adults on kidney replacement therapy

Author

Boenink, Rianne, Stel, Vianda S., Waldum-Grevbo, Bård E., Collart, Frederic, Kerschbaum, Julia, Heaf, James G., de Meester, Johan, Finne, Patrik, García-Marcos, Sergio A., Evans, Marie, Ambühl, Patrice M., Arici, Mustafa, Ayav, Carole, Steenkamp, Retha, Cases, Aleix, Traynor, Jamie P., Palsson, Runolfur, Zoccali, Carmine, Massy, Ziad A., Jager, Kitty J., and Kramer, Anneke

Published
2020
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46. Animal models to study cognitive impairment of chronic kidney disease.

Author

Silva, Pedro H. Imenez, Pepin, Marion, Figurek, Andreja, Gutiérrez-Jiménez, Eugenio, Bobot, Mickaël, Iervolino, Anna, Mattace-Raso, Francesco, Hoorn, Ewout J., Bailey, Matthew A., Hénaut, Lucie, Nielsen, Rikke, Frische, Sebastian, Trepiccione, Francesco, Hafez, Gaye, Altunkaynak, Hande O., Endlich, Nicole, Unwin, Robert, Capasso, Giovambattista, Pesic, Vesna, and Massy, Ziad

Subjects
CHRONIC kidney failure, COGNITION disorders, EXECUTIVE function, ACTIVITIES of daily living, COGNITION
Abstract

Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD), and its prevalence increases with progressive loss of kidney function. MCI is characterized by a decline in cognitive performance greater than expected for an individual age and education level but with minimal impairment of instrumental activities of daily living. Deterioration can affect one or several cognitive domains (attention, memory, executive functions, language, and perceptual motor or social cognition). Given the increasing prevalence of kidney disease, more and more people with CKD will also develop MCI causing an enormous disease burden for these individuals, their relatives, and society. However, the underlying pathomechanisms are poorly understood, and current therapies mostly aim at supporting patients in their daily lives. This illustrates the urgent need to elucidate the pathogenesis and potential therapeutic targets and test novel therapies in appropriate preclinical models. Here, we will outline the necessary criteria for experimental modeling of cognitive disorders in CKD. We discuss the use of mice, rats, and zebrafish as model systems and present valuable techniques through which kidney function and cognitive impairment can be assessed in this setting. Our objective is to enable researchers to overcome hurdles and accelerate preclinical research aimed at improving the therapy of people with CKD and MCI. [ABSTRACT FROM AUTHOR]

Published
2024
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47. A new approach for cognitive impairment pattern in chronic kidney disease.

Author

Levassort, Hélène, Boucquemont, Julie, Pinho, Natalia Alencar de, Lambert, Oriane, Helmer, Catherine, Metzger, Marie, Teillet, Laurent, Frimat, Luc, Combe, Christian, Fouque, Denis, Laville, Maurice, Jacquelinet, Christian, Liabeuf, Sophie, Stengel, Bénédicte, Massy, Ziad A, Pépin, Marion, and Collaborators, the CKD-REIN Study

Subjects
MINI-Mental State Examination, CHRONIC kidney failure, COGNITION disorders, CARDIOVASCULAR diseases risk factors, ALZHEIMER'S disease, ATTENTION
Abstract

Background Chronic kidney disease (CKD) is associated with an elevated risk of neurocognitive disorders (NCDs). It remains unclear whether CKD-related NCDs have a specific cognitive pattern or are earlier-onset phenotypes of the main NCDs (vascular NCDs and Alzheimer's disease). Methods We used the Mini Mental State Examination score (MMSE) to assess cognitive patterns in 3003 CKD patients (stage 3–4) followed up over 5 years in the Chronic Kidney Disease–Renal Epidemiology and Information Network (CKD-REIN) cohort. After normalizing MMSE scores to a 0-to-100 scale, the associations between the baseline estimated glomerular filtration rate (eGFR, using the Chronic Kidney Disease Epidemiology Collaboration creatinine formula) and changes in each MMSE domain score were assessed in linear mixed models. Results Patients (age: 67 ± 13 years old; males: 65%, mean eGFR: 33± 12 mL/min/1.73 m2) had a good baseline cognitive functions: the mean MMSE score was 26.9/30 ± 2.9. After adjustment for age, sex, educational level, depression (past or present), cardiovascular risk factors and cerebrovascular disease, a lower baseline eGFR (per 10 mL/min/1.73 m2) was associated with a 0.53-point decrement [ P  < .001; 95% confidence interval (CI) (–0.98, –0.08)] for orientation, a 1.04-point decrement [ P  = .03; 95% CI (–1.96, –0.13)] for attention and calculation, a 0.78-point decrement [ P  = .003; 95% CI (–1.30, –0.27)] for language, and a 0.94-point decrement [ P  = .02; 95% CI (–1.75, –0.13)] for praxis. Baseline eGFR was not, however, associated with significant changes over time in MMSE domain scores. Conclusion A lower eGFR in CKD patients was associated with early impairments in certain cognitive domains: praxis, language and attention domains before an obvious cognitive decline. Early detection of NCD in CKD patients must be performed before clinically cognitive decline using preferably tests assessing executive, attentional functions and language, rather than memory tests. This early cognitive screening could lead to a better management of cognitive impairment and their consequences on CKD management. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Extracorporeal Techniques in Kidney Failure.

Author

Meijers, Bjorn, Vega, Almudena, Juillard, Laurent, Kawanishi, Hideki, Kirsch, Alexander H., Maduell, Francisco, Massy, Ziad A., Mitra, Sandip, Vanholder, Raymond, Ronco, Claudio, and Cozzolino, Mario

Subjects
KIDNEY failure, CHRONIC kidney failure, OVERALL survival, MOLECULAR spectra
Abstract

During the last decades, various strategies have been optimized to enhance clearance of a variable spectrum of retained molecules to ensure hemodynamic tolerance to fluid removal and improve long-term survival in patients affected by kidney failure. Treatment effects are the result of the interaction of individual patient characteristics with device characteristics and treatment prescription. Historically, the nephrology community aimed to provide adequate treatment, along with the best possible quality of life and outcomes. In this article, we analyzed blood purification techniques that have been developed with their different characteristics. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Haemoglobin trajectories in chronic kidney disease and risk of major adverse cardiovascular events.

Author

Gall, Lisa Le, Harambat, Jérôme, Combe, Christian, Philipps, Viviane, Proust-Lima, Cécile, Dussartre, Maris, Drüeke, Tilman, Choukroun, Gabriel, Fouque, Denis, Frimat, Luc, Jacquelinet, Christian, Laville, Maurice, Liabeuf, Sophie, Pecoits-Filho, Roberto, Massy, Ziad A, Stengel, Bénédicte, Pinho, Natalia Alencar de, Leffondré, Karen, Prezelin-Reydit, Mathilde, and group, the CKD-REIN study

Subjects
MAJOR adverse cardiovascular events, DISEASE risk factors, CHRONIC kidney failure, HEMOGLOBINS, RENAL replacement therapy
Abstract

Background The trajectories of haemoglobin in patients with chronic kidney disease (CKD) have been poorly described. In such patients, we aimed to identify typical haemoglobin trajectory profiles and estimate their risks of major adverse cardiovascular events (MACE). Methods We used 5-year longitudinal data from the CKD-REIN cohort patients with moderate to severe CKD enrolled from 40 nationally representative nephrology clinics in France. A joint latent class model was used to estimate, in different classes of haemoglobin trajectory, the competing risks of (i) MACE + defined as the first event among cardiovascular death, non-fatal myocardial infarction, stroke or hospitalization for acute heart failure, (ii) initiation of kidney replacement therapy (KRT) and (iii) non-cardiovascular death. Results During the follow-up, we gathered 33 874 haemoglobin measurements from 3011 subjects (median, 10 per patient). We identified five distinct haemoglobin trajectory profiles. The predominant profile (n  = 1885, 62.6%) showed an overall stable trajectory and low risks of events. The four other profiles had nonlinear declining trajectories: early strong decline (n  = 257, 8.5%), late strong decline (n  = 75, 2.5%), early moderate decline (n  = 356, 11.8%) and late moderate decline (n  = 438, 14.6%). The four profiles had different risks of MACE, while the risks of KRT and non-cardiovascular death consistently increased from the haemoglobin decline. Conclusion In this study, we observed that two-thirds of patients had a stable haemoglobin trajectory and low risks of adverse events. The other third had a nonlinear trajectory declining at different rates, with increased risks of events. Better attention should be paid to dynamic changes of haemoglobin in CKD. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Ionized and total magnesium levels in patients with chronic kidney disease: associated factors and outcomes.

Author

Pluquet, Maxime, Kamel, Said, Pinho, Natalia Alencar de, Mansencal, Nicolas, Combe, Christian, Metzger, Marie, Massy, Ziad A, Liabeuf, Sophie, and Laville, Solène M

Subjects
CHRONIC kidney failure, CHRONICALLY ill, MAJOR adverse cardiovascular events, DISEASE complications, PROPORTIONAL hazards models
Abstract

Background The association between hypo- and/or hypermagnesaemia and cardiovascular (CV) outcomes or mortality has shown conflicting results in chronic kidney disease (CKD) and has been conducted on total magnesium (tMg) levels. Thus, the objectives of the present study were to (i) describe the serum ionized Mg (iMg) concentration in patients at various CKD stages, (ii) measure the correlation between iMg and tMg concentrations, (iii) identify their associated factors and (iv) determine whether serum tMg and/or iMg concentrations are associated with major adverse cardiovascular events (MACE) and mortality before kidney replacement therapy in CKD patients. Methods Chronic Kidney Disease–Renal Epidemiology and Information Network (CKD-REIN) is a prospective cohort of CKD patients with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Baseline iMg and tMg serum concentrations were centrally measured. Adjusted cause-specific Cox proportional hazard models were used to estimate hazard ratios (HRs) for first MACE and for mortality. Results Of the 2419 included patients, median age was 68 years, and the mean eGFR was 34.8 mL/min/1.73 m2. Concentrations of serum iMg and tMg were strongly correlated (r = 0.89, P  < .001) and were independently associated with eGFR. The adjusted HR [95% confidence interval (CI)] for MACE associated with the baseline serum tMg level was 1.27 (0.95; 1.69) for patients in Tertile 1 and 1.56 (1.18; 2.06) for patients in Tertile 3, relative to patients in Tertile 2. The HR (95% CI) of death according to serum tMg concentration was increased in Tertile 3 [1.48 (1.11; 1.97)]. The adjusted risk for MACE and mortality (all-cause or CV) associated with the baseline serum iMg level was not significantly different between tertiles. Conclusions Our analysis of a large cohort of patients with moderate-to-advanced CKD demonstrated that individuals with higher serum tMg concentrations, although still within the normal range, had a greater likelihood of MACE and mortality. However, serum iMg levels were not associated with these outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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