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12. Skin changes in streptozotocin-induced diabetic rats

Author

Andrade, Thiago Antônio Moretti, primary, Masson-Meyers, Daniela Santos, additional, Caetano, Guilherme Ferreira, additional, Terra, Vânia Aparecida, additional, Ovidio, Paula Payão, additional, Jordão-Júnior, Alceu Afonso, additional, and Frade, Marco Andrey Cipriani, additional

Published
2017
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13. Skin changes in streptozotocin-induced diabetic rats.

Author

Frade, Marco Andrey Cipriani, Andrade, Thiago Antônio Moretti, Caetano, Guilherme Ferreira, Masson-Meyers, Daniela Santos, Terra, Vânia Aparecida, Ovidio, Paula Payão, and Jordão-Júnior, Alceu Afonso

Subjects
*STREPTOZOTOCIN, *SKIN disease genetics, *GENETICS of diabetes, *IMMUNOHISTOCHEMISTRY, *BIOCHEMISTRY, *HOMEOSTASIS, *ANIMAL models of diabetes, *PHYSIOLOGY
Abstract

Diabetes can cause serious health complications, which can affect every organ of the body, including the skin. The molecular etiology has not yet been clarified for all diabetic skin conditions. Thus, this study aimed to investigate the changes of diabetes in skin compared to non-diabetic skin in rats. Fifteen days after establishing the diabetic status, skin samples from the dorsum-cervical region were harvested for subsequent analysis of alterations caused by diabetes. Our results demonstrate that diabetes stimulated higher inflammation and oxidative stress in skin, but antioxidant defense levels were lower compared to the non-diabetic group (p < 0.05). This could have been related to a decreased number of blood vessels and low expression of VEGF, eNOS and TGF-β1. Finally, insulin signaling proteins IRS, Akt, Shc and ERK showed a low expression in the diabetic group. Thus, our study shows that the pathology of diabetes induced immunohistopathological and biochemical skin changes compared to non-diabetic skin in rats. [ABSTRACT FROM AUTHOR]

Published
2017
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