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1. Roughening of $k$-mer growing interfaces in stationary regimes

Author

Grynberg, M. D. and Massolo, F. I. Schaposnik

Subjects
Condensed Matter - Statistical Mechanics
Abstract

We discuss the steady state dynamics of interfaces with periodic boundary conditions arising from body-centered solid-on-solid growth models in $1+1$ dimensions involving random aggregation of extended particles (dimers, trimers,\,$\cdots,k$-mers). Roughening exponents as well as width and maximal height distributions can be evaluated directly in stationary regimes by mapping the dynamics onto an asymmetric simple exclusion process with $k$-\,type of vacancies. Although for $k \ge 2$ the dynamics is partitioned into an exponentially large number of sectors of motion, the results obtained in some generic cases strongly suggest a universal scaling behavior closely following that of monomer interfaces., Comment: 9 pages, 4 figures. Brief corrections and additions. To appear in Phys. Rev. E

Published
2017
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2. Treatment of Poor-Risk Neuroblastoma with Intensive Chemotherapy and Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

Author

Lanino, E., Parasole, R., Garaventa, A., Arrighini, A., Bagnulo, S., Carli, M., Comis, S., di Montezemolo, L. Cordero, Di Tullio, M. T., Massolo, F., Mazzanti, P., Paolucci, P., Pasino, M., Boni, L., Tamaro, P., De Bernardi, B., Freund, Mathias, editor, Link, Hartmut, editor, Schmidt, Reinhold E., editor, and Welte, Karl, editor

Published
1992
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3. Diamond-Blackfan anaemia in the Italian population

Author

Ramenghi, U., Garelli, E., Valtolina, S., Campagnoli, M. F., Timeus, F., Crescenzio, N., Mair, M., Varotto, S., D'Avanzo, M., Nobili, B., Massolo, F., Mori, P. G., Locatelli, F., Gustavsson, P., Dahl, N., and Dianzani, I.

Published
1999

4. Germ Cell Tumours in Children: A Report of 84 Cases

Author

Curto, M. Lo, primary, Provenzano, G., additional, Zingone, A., additional, Bagnulo, S., additional, Bernini, G., additional, Cecchetto, G., additional, De Bernardi, E., additional, De Grazia, E., additional, De Laurentis, C., additional, Di Benedetto, S., additional, Di Pace, M., additional, Di Tullio, M.T., additional, Fagnani, A.M., additional, Felici, L., additional, Cascio, M. Lo, additional, Piccolo, S. Lo, additional, Macchia, P., additional, Massolo, F., additional, Santoro, N., additional, Siracusa, F., additional, Tamaro, P., additional, and Targhetta, R., additional

Published
1994
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6. Recombinant growth hormone treatment in short patients with thalassemia major: results after 24 and 36 months

Author

A Acquafredda, Luciano Cavallo, Mariangela Cisternino, Galati M, C. Zecchino, V. De Sanctis, Massolo F, and Caruso Nicoletti M

Subjects
Male, medicine.medical_specialty, Pediatrics, Time Factors, Endocrinology, Diabetes and Metabolism, Thalassemia, Rhgh treatment, Short stature, Gastroenterology, Group B, Endocrinology, Internal medicine, medicine, Humans, Recombinant growth hormone, Growth Disorders, business.industry, Human Growth Hormone, Puberty, beta-Thalassemia, Bone age, medicine.disease, Body Height, Concomitant, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, business, Prolonged treatment
Abstract

Treatment with recombinant growth hormone (rhGH), 0.6 IU/kg/week s.c., previously successfully conducted for one year, was continued in 15 (Group A) and 8 (Group B) short thalassemia major patients with reduced GH reserve, for two and three years, respectively. In Group A, height for chronological: age (Ht SDSca) increased significantly (p = 0.021) from the start of treatment, but the positive effect was only apparent because of the concomitant slight worsening of height for bone age (Ht SDSba). Median AHt SDScA/AHt SDSba was

Published
2001

8. Bloodstream infections in children with cancer: a multicentre surveillance study of the Italian Association of Paediatric Haematology and Oncology. Supportive Therapy Group-Infectious Diseases Section

Author

Viscoli, Claudio, Castagnola, Elio, Giacchino, M, Cesáro, S, Properzi, E, Tucci, F, Mura, R. M, Alvisi, P, Zanazzo, G, Surico, G, Bonetti, F, De Sio, L, Izzi, G, Di Cataldo, A, Ziino, O, Massolo, F, Nardi, M, Santoro, N, and Binda, S.

Subjects
Male, bacteraemia, Neutropenia, Drug Resistance, fungaemia, Bacteremia, Drug Resistance, Microbial, Microbial, Italy, Neoplasms, Humans, Child, Female, Fungemia, Prospective Studies, cancer infections
Abstract

A one-year prospective, multicentre surveillance study on aetiology, main clinical features and outcome of bloodstream infections in children with cancer was conducted in 18 paediatric haematology centres belonging to the Italian Association for Paediatric Haematology and Oncology. A total of 191 bloodstream infections were reported during the study period. Of them, 123 (64%) occurred in neutropenic and 68 (36%) in non-neutropenic patients. Gram-positive cocci caused 45% (85/191) of the episodes, gram-negative rods 41% (78/191), and fungi 9% (18/191). The remaining 5% (10/191) of the episodes were poly-microbial infections. A total of 204 pathogens were isolated (46% gram-positive cocci; 44% gram-negative rods; and 10% fungi). The aetiologic distribution was similar among neutropenic and non-neutropenic patients. A correlation between the infection and the presence of an indwelling central venous catheter was found in 20% (23/114) of the episodes among neutropenic patients and in 55% (23/62) among non-neutropenic patients. Gram-negative micro-organisms were isolated in an unusually high proportion of catheter-related infections (48%). The overall mortality rate from any cause within 30 days from the first positive blood culture was 11%, and was higher among patients who were neutropenic at the onset of the infection than among those who were not neutropenic (15 versus 4%, P = 0.03). In addition, the mortality was significantly higher in recipients of bone marrow transplantation than in patients with acute leukaemia or solid tumour (21, 11 and 6%, respectively) and was also higher in fungaemias and poly-microbial infections (22 and 30%) than in single gram-positive and gram-negative bacteraemias (11 and 6%).

Published
1999

9. Short stature and body proportion in thalassaemia

Author

CARUSO NICOLETTI, M, DE SANCTIS, V, Capra, M, Cardinale, G, Cuccia, L, DI GREGORIO, F, Filosa, A, Galati, Mc, Lauriola, A, Malizia, R, Mangiagli, A, Massolo, F, Mastrangelo, C, Meo, A, Messina, Maria Francesca, Ponzi, G, Raiola, G, Ruggiero, L, Tamborino, G, and Saviano, A.

Subjects
Adult, Male, Aging, Adolescent, Body disproportion, Growth, Short stature, Short trunk, Thalassaemia, beta-Thalassemia, Deferoxamine, Iron Chelating Agents, Body Height, Child, Preschool, Ferritins, Body Constitution, Humans, Blood Transfusion, Female, Child
Abstract

Short stature and short trunk have been reported in thalassaemic patients. We report a study on stature and body proportions in 476 patients (2-36 years old) with beta-thalassaemia major, followed in 12 Italian centres. Auxological data (standing height, sitting height, subischial leg length, target height), haematological data (age at first transfusion, age at start of desferrioxamine [DFX] chelation, mean dose of DFX, ferritin values) and information regarding the presence of endocrine disorders and of bone lesions, were collected and analysed according to the age of the patients, in order to investigate the natural history of the disproportion and the role of siderosis, DFX toxicity and endocrine disorders. Our data indicate that about 18% of thalassaemic patients exhibit short stature; disproportion between the upper and lower body segments is present in 14%; however, a short trunk despite normal stature is present in another 40% of patients. This is due to a spinal growth impairment which starts in infancy and progressively aggravates. We think that a short trunk is peculiar to the disease itself; however, other factors such as hypogonadism, siderosis, or DFX-induced bone dysplasia are probably involved in aggravating the body disproportion in these patients.

Published
1999

14. Germ cell tumors in childhood | [Tumori a cellule germinali in età pediatrica]

Author

Lo Curto, M, Lo Piccolo MS, Arrighini, A, Bagnulo, S, Bernini, C, Carli, M, Cecchetto, G, De Grazia, E, De Laurentis, T, DI CATALDO, Andrea, Di Pace MR, Fagnani, Am, Favre, C, Indolfi, P, Marradi, G, Massolo, F, Mazzarino, I, Mazzeo, L, Menna, G, Putamigno, P, Santoro, N, Siracusa, F, Tamaro, P, Targhetta, P, Riv Ital Pediatr 23:414 421, De Bernardi B. Tumori a. cellule germinali in età p. e. d. i. a. t. r. i. c. a., and 1997

Subjects
Seminomatous Tumors, Teratoma, Germ Cell Tumor
Published
1997

16. Disseminated poor-risk neuroblastoma. Results of an 'intensive' protocol (AIEOP NB-85). [Neuroblastoma disseminato a cattiva prognosi. Risultati di un protocollo intensivo (AIEOP NB-85)]

Author

Corciulo, P, Deb, G, Mazzei, A, Bisogno, G, Surico, Gm, Tonello, M, Garaventa, A, Arrighini, A, Lumia, F, Zanazzo, G, Gallisai, D, Massolo, F, Cornelli, Pe, Targhetta, R, DI CATALDO, Andrea, Ragusa, R, Acquaviva, A, Bernini, G, Fiorillo, A, Santoro, N, Ivani, G, Zucchetti, P, Cominetti, M, Viscardi, E, Castagnola, E, and De Bernardi, B.

Published
1993

19. Malattia di Hodgkin in età pediatrica: risultati del protocollo AIEOP-MH'83-CNR

Author

Vecchi, V, Bontempi, N, Testi, Anna Maria, Comelli, A, Miano, C, Carli, M, Aricò, M, Di Tullio MT, Grazia, G, Massolo, F, Colella, R, Schirilò, G, Macchia, P, Tamaro, P, Cornelli, P, Santoro, N, Lo Curto, M, Izzi, G, Arrighini, A, Targhetta, R, Ladogana, S, Magro, S, Lippi, A, Amici, A, Conter, V, Fiorillo, A, Borghetti, A, Facchini, E, Rondelli, R, and Burnelli, R.

Published
1992

20. Stage IV-S neuroblastoma. 76 Cases treated by the Cooperative Group for Neuroblastoma of the Italian Association of Paediatric Haematology and Oncology [NEUROBLASTOMA STADIO IV-S. 76 CASI TRATTATI DAL GRUPPO COOPERATIVO NEUROBLASTOMA DELL'ASSOCIAZIONE ITALIANA DI EMATOLOGIA ED ONCOLOGIA PEDIATRICA]

Author

De Bernardi, B, Mancini, A, Carli, M, Casale, F, Bagnulo, S, Corciulo, P, Deb, G, Donfrancesco, A, Rosito, P, Arrighini, A, Provenzi, P, DI CATALDO, Andrea, Fabbretti, G, Felici, L, Izzi, Gc, Provenzano, G, Massolo, F, Mazzei, A, Fiorillo, A, Santoro, R, Targhetta, R, Tamaro, P, Fagnani, Am, Gallisai, D, Conte, M, Tonello, M, Cordero di Montezemolo LRiv Ital Pediatr 18:414 426, and 1992

Published
1992

21. Malattia di Hodgkin in età pediatrica: risultati preliminari del protocollo AIEOP-MH'89-CNR

Author

Vecchi, V, Bontempi, N, Aricò, M, Comelli, A, Miano, C, Carli, M, Arrighini, A, Di Tullio MT, Grazia, G, Massolo, F, Colella, R, Santoro, N, Tamaro, P, Schilirò, G, Macchia, P, Testi, Anna Maria, Cornelli, P, Lo Curto, M, Targhetta, R, Ladogana, S, Magro, S, Lippi, A, Amici, A, Conter, V, Portaleone, D, Natale, D, Marradi, P, Pericoli, R, Burnelli, R, Civino, C, Pession, A, and Rondelli, R.

Published
1992

23. Diamond-Blackfan anaemia in the Italian population

Author

Ramenghi, U, Garelli, E, Valtolina, S, Campagnoli, M F, Timeus, F, Crescenzio, N, Mair, M, Varotto, S, D'Avanzo, M, Nobili, B, Massolo, F, Mori, P G, Locatelli, Franco, Gustavsson, P, Dahl, N, Dianzani, I, Locatelli, F (ORCID:0000-0002-7976-3654), Ramenghi, U, Garelli, E, Valtolina, S, Campagnoli, M F, Timeus, F, Crescenzio, N, Mair, M, Varotto, S, D'Avanzo, M, Nobili, B, Massolo, F, Mori, P G, Locatelli, Franco, Gustavsson, P, Dahl, N, Dianzani, I, and Locatelli, F (ORCID:0000-0002-7976-3654)

Abstract

Diamond-Blackfan anaemia (DBA) is a congenital disease characterized by defective erythroid progenitor maturation; 30% of patients have congenital malformations. The link between these malformations and defective erythropoiesis is unclear: a defect in a molecule acting both on embryo development and haemopoiesis has been proposed, Inheritance is autosomal dominant in most familial cases, but recessive families have also been reported. Many cases are sporadic. A DBA locus has been mapped on chromosome 19q13.2 (Gustavsson et al, 1997), but several families unlinked to this locus have also been reported (Gustavsson et al, 1998).This paper presents clinical, epidemiological and molecular data for DBA in the Italian population, Segregation analysis of 19q markers in patients with DBA showed exclusion of this locus in 5/12 families with inherited DBA. There was evidently locus heterogeneity for DBA in this population. A new microdeletion was identified in one patient. Other families, in which DBA segregates concordantly with the 19q critical region, suggest incomplete penetrance and expressivity of the DBA gene.

Published
1999

24. Mutational screening of thrombopoietin receptor gene (c-mpl) in patients with congenital thrombocytopenia and absent radii (TAR)

Author

Strippoli, P, Savoia, A, Iolascon, A, Tonelli, R, Savino, Mariachiara, Giordano, P, D'Avanzo, M, Massolo, F, Locatelli, Franco, Borgna, C, De Mattia, D, Zelante, L, Paolucci, Giorgio, Bagnara, G P, Savino, M, Locatelli, F (ORCID:0000-0002-7976-3654), Paolucci, G, Strippoli, P, Savoia, A, Iolascon, A, Tonelli, R, Savino, Mariachiara, Giordano, P, D'Avanzo, M, Massolo, F, Locatelli, Franco, Borgna, C, De Mattia, D, Zelante, L, Paolucci, Giorgio, Bagnara, G P, Savino, M, Locatelli, F (ORCID:0000-0002-7976-3654), and Paolucci, G

Abstract

Thrombocytopenia with absent radii (TAR) is a rare autosomal recessive disease characterized by hypomega-karyocytic thrombocytopenia and bilateral radial aplasia. We performed mutational screening of coding and promoter regions of the c-mpl gene, encoding thrombopoietin (TPO) receptor, by sequence analysis in four unrelated patients affected by TAR syndrome. Our results indicate that c-mpl gene mutations are not a common cause of thrombocytopenia in TAR syndrome.

Published
1998

30. Evidence suggesting an additional control mechanism regulating episodic secretion of luteinizing hormone and follicle stimulating hormone in pre-pubertal children and post-menopausal women.

Author

Genazzani, A D, Petraglia, F, Gastaldi, M, Volpogni, C, Gamba, O, Massolo, F, and Genazzani, A R

Abstract

The possible differential regulation of pulsatile follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion in pre-pubertal children and in post-menopausal women was investigated. Children were studied for 4 h and post-menopausal women for 6 h; blood samples were taken every 10 min. Post-menopausal women were studied before and 21 days after administration of a single i.m. dose of gonadotrophin-releasing hormone (GnRH) analogue. Eight post-menopausal women and 18 children (nine boys and nine girls) were enrolled. The children were divided into two groups: A, at Tanner stages 0-1 (four boys and three girls); B, at Tanner stage 2-3 (five boys and six girls). Plasma LH and FSH concentrations were determined using an immunofluorimetric assay. Time series were analysed and the specific concordance (SC) index was computed to determine the degree of concordance between episodes of LH and FSH secretion. While children of group A had LH concentrations below the minimal detectable dose of 0.1 IU/l, group B showed measurable LH plasma concentrations (1.4 +/- 0.3 IU/l, mean +/- SEM). Plasma FSH concentrations were detectable in both groups. Group A showed FSH plasma concentrations significantly lower than those of group B (0.75 +/- 0.2 and 1.95 +/- 0.4 IU/l respectively; P < 0.05), but FSH pulse frequency was higher in group A (P < 0.05). Children of group B showed significant concomitance of LH and FSH secretory events at time 0 (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) [ABSTRACT FROM AUTHOR]

Published
1994

31. The Outcome of Wilms’ Tumor in Infants, Italy 1970-79

Author

Pastore, G., Di Montezemolo, L. Cordero, Del Prever, A. Brach, Bartolozzi, G., Carli, M., Castello, M., Ceci, A., Fossati-Bellani, F., Guazzelli, C., Curto, M. Lo, Madon, E., Marchi, A., Massolo, F., Mori, P.G., Paolucci, G., Pianca, C., Rosati, M., and Tamaro, P.

Abstract

Thirty-four infants under 1 year of age with Wilms’ tumor were diagnosed and treated in 14 Italian pediatric oncology units during 1970-79. The 3-year survival rates decreased with higher group unilateral tumors: 95% in group I Wilms’ tumor, 75% in group II and 20% in group III. The survival rates for children with group I and II Wilms’ tumor were similar for those who were treated with surgery and chemotherapy and those who also received postoperative radiotherapy. During 1975-79 fewer patients with group I Wilms’ tumor received radiotherapy (1 of 11) than during 1970-74 (4 of 6, p < 0.05). All these children are alive at this writing.

Published
1982
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40. Acute childhood idiopathic thrombocytopenic purpura: AIEOP consensus guidelines for diagnosis and treatment

Author

Mattia, D., Del Principe, D., Del Vecchio, G. C., Jankovic, M., Arrighini, A., Giordano, P., Menichelli, A., Mori, P., Zecca, M., Pession, A., Schettini, F., Masera, G., Macchia, P., Amendola, G., Baligan, M., Baronci, C., Biddau, P., Borgna, C., Crupi, S., Santis, R., Felici, L., Laffranchi, M., Mancuso, G., Massolo, F., Nespoli, L., Nobili, B., Ramenghi, U., Giovanna Russo, and Tucci, F.

Subjects
idiopathic thrombocytopenic purpura, children, guidelines

41. Porpora trombocitopenica idiopatica (immune) (PTI) acuta in eta pediatrica. Linee guida AIEOP per la diagnosi ed il trattamento

Author

Mattia, D., Del Principe, D., Del Vecchio, G. C., Jankovic, M., Arrighini, A., Paola Giordano, Menichelli, A., Mori, P. G., Zecca, M., Schettini, F., Macchia, P. A., Masera, G., Amendola, G., Baligan, M., Baronci, C., Biddau, P. F., Borgna, C., Crupi, S., Santis, R., Felici, L., Laffranchi, M., Mancuso, G., Massolo, F., Nespoli, L., Nobili, B., Ramenghi, U., Russo, G., and Tucci, F.

Subjects
linee guida, porpora trombocitopenica immune, bambini

42. Undifferentiated (embryonal) sarcoma of the liver in childhood the experience of the Italian Cooperative croup on Pédiatrie Soft Tissue Sarcoma,Sarcoma Indifferenziato (embrionale) del fegato in età pediatrica L'esperienza del Cruppo Cooperative Italiano per il trattamento dei Sarcomi delle Parti Molli in età pediatrica

Author

Bisogno, G., Cecchetto, G., Dall Igna, P., Talenti, E., Scarzello, G., Basso, E., Anna Rita Ferrari, Dallorso, S., Mancini, A., Massolo, F., Zanetti, I., and Carli, M.

45. Trattamento del dolore nel bambino affetto DA neoplasia

Author

Clerico, A., Ragni, G., Saita, L., Antimi, A., Castello, M. A., Bernini, G., Bagnulo, S., Andrea Di Cataldo, Haupt, R., Jankovic, M., Izzi, G., Lo Curto, M., Massolo, F., Macchia, P., Mancini, A. F., and Santoro, N.

46. Mutational screening of thrombopoietin receptor gene (c-mpl) in patients with congenital thrombocytopaenia and absent radii (TAR)

Author

Franco Locatelli, Maria Savino, Roberto Tonelli, Michele D'Avanzo, Paola Giordano, Domenico De Mattia, Guido Paolucci, Caterina Borgna, Achille Iolascon, Anna Savoia, F. Massolo, Gian Paolo Bagnara, Pierluigi Strippoli, Leopoldo Zelante, Strippoli, P, Savoia, Anna, Iolascon, A, Tonelli, R, Savino, M, Giordano, P, D'Avanzo, M, Massolo, F, Locatelli, F, Borgna, C, DE MATTIA, D, Zelante, L, Paolucci, G, and Bagnara, Gb

Subjects
Male, Adolescent, viruses, DNA Mutational Analysis, Gene mutation, Biology, medicine.disease_cause, complex mixtures, Polymerase Chain Reaction, Congenital, Megakaryocytopoiesis, Mutational screening, Thrombocytopenia absent radii syndrome, TPO-c-mpl system, Pathogenesis, Tar (tobacco residue), Bilateral radial aplasia, hemic and lymphatic diseases, Proto-Oncogene Proteins, medicine, Humans, Receptors, Cytokine, Child, Gene, Thrombopoietin, Mutation, TAR syndrome, Infant, Hematology, Syndrome, medicine.disease, Thrombocytopenia, Neoplasm Proteins, Radius, Cancer research, Female, Receptors, Thrombopoietin
Abstract

Thrombocytopenia with absent radii (TAR) is a rare autosomal recessive disease characterized by hypomegakaryocytic thrombocytopenia and bilateral radial aplasia. We performed mutational screening of coding and promoter regions of the c-mpl gene, encoding thrombopoietin (TPO) receptor, by sequence analysis in four unrelated patients affected by TAR syndrome. Our results indicate that c-mpl gene mutations are not a common cause of thrombocytopenia in TAR syndrome.

Published
1998

47. Late deaths and second primary malignancies among long-term survivors of childhood cancer: an Italian multicentre study

Author

Giuseppe Masera, Maria Grazia Zurlo, Guido Pastore, Domenico Rosati, Benedetto Terracini, F. Massolo, Franca Fossati-Bellani, Pier Franco Biddau, Manuel A. Castello, Paolo Tamaro, Antonio Russo, Terracini, B, Pastore, G, Zurlo, Mg, Masera, G, Fossati Bellani, F, Castello, M, Tamaro, Paolo, Massolo, F, Rosati, D, and Biddau, Pf

Subjects
Oncology, Male, medicine.medical_specialty, Myeloid, Time Factors, Malignant Mesenchymoma, Thyroid carcinoma, Neoplasms, Multiple Primary, hemic and lymphatic diseases, Internal medicine, Epidemiology, medicine, Humans, Prospective Studies, Registries, cancer survival, Child, business.industry, Bilateral Breast Carcinoma, Astrocytoma, medicine.disease, Surgery, Lymphoma, medicine.anatomical_structure, Italy, Female, Chondrosarcoma, business, Follow-Up Studies
Abstract

A multicentre registry of children who had been successfully removed from therapy for some common childhood cancers (Hodgkin's disease, non-Hodgkin's lymphoma, neuroblastoma, nephroblastoma, acute lymphatic leukaemia and other leukaemias) was established in Italy in 1981 . The present study describes mortality and occurrence of second primary malignancies (SPMs) among 1467 children who were alive when the registry was established. Follow-up ended on December 31, 1983 for mortality and 1 year later for the occurrence of SPMs. Sixty-seven deaths were recorded, 11 of which wre due to causes other than progression of the original disease. Eleven incident SPMs were identified (i.e. 3 acute myeloid leukaemias, 3 thyroid carcinomas, 1 bilateral breast carcinoma, 1 liver malignant mesenchymoma, 1 astrocytoma, 1 chondrosarcoma and 1 osteosarcoma) corresponding to an incidence rate of 2.11000 patient-years at risk. Anecdotal reports were collected regarding 2 further SPMs (a thyroid carcinoma and a myeloid leukaemia) as well as several benign tumours, including 2 mammary fibroadenomas.

Published
1987

48. The outcome of Wilms' tumor in infants. Italy 1970-79

Author

F. Fossati-Bellani, F. Massolo, Paolo Tamaro, Modesto Carli, Antonietta Marchi, Adriana Ceci, A. Brach del Prever, Guido Pastore, Carlo Guazzelli, L Cordero di Montezemolo, C. Pianca, G. Bartolozzi, Enrico Madon, M. Lo Curto, Guido Paolucci, Manuel A. Castello, P.G. Mori, M. Rosati, Pastore, G, Cordero di Montezemolo, L, Brach del Prever, A, Bartolozzi, G, Carli, M, Castello, M, Ceci, A, Fossati Bellani, F, Guazzelli, C, Lo Curto, M, Madon, E, Marchi, A, Massolo, F, Mori, Pg, Paolucci, G, Pianca, C, Rosati, M, and Tamaro, Paolo

Subjects
Male, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Group ii, Postoperative radiotherapy, Wilms Tumor, medicine, Pediatric oncology, Humans, Retrospective Studies, Chemotherapy, business.industry, Infant, Newborn, Infant, Wilms' tumor, Retrospective cohort study, General Medicine, medicine.disease, Infant newborn, Kidney Neoplasms, Surgery, Radiation therapy, Oncology, Italy, Female, business
Abstract

Thirty-four infants under 1 year of age with Wilms’ tumor were diagnosed and treated in 14 Italian pediatric oncology units during 1970-79. The 3-year survival rates decreased with higher group unilateral tumors: 95% in group I Wilms’ tumor, 75% in group II and 20% in group III. The survival rates for children with group I and II Wilms’ tumor were similar for those who were treated with surgery and chemotherapy and those who also received postoperative radiotherapy. During 1975-79 fewer patients with group I Wilms’ tumor received radiotherapy (1 of 11) than during 1970-74 (4 of 6, p < 0.05). All these children are alive at this writing.

Published
1982

49. Postharvest shelf life extension of minimally processed kale at ambient and refrigerated storage by use of modified atmosphere.

Author

Lourenco AB, Casajús V, Ramos R, Massolo F, Salinas C, Civello P, and Martínez G

Subjects
Ribulose-Bisphosphate Carboxylase, Refrigeration, Food Handling methods, Flavonoids analysis, Color, Temperature, Food Preservation methods, Food Storage methods, Brassica chemistry, Plant Leaves chemistry, Chlorophyll analysis, Food Packaging methods, Antioxidants analysis, Phenols analysis
Abstract

Kale is becoming an important vegetable worldwide, mainly due to its nutritional properties. Kale leaves can be marketed whole, although minimal processing is also in demand. In this article, it was analyzed the effect of packaging in a modified atmosphere of fresh-cut kale leaves stored at 20 °C and 4 °C. Kale leaves were cut into 4 × 4 cm strips and stored in low-density polyethylene bags. Samples processed in the same way but stored in PVC were used as controls. Leaves kept in a modified atmosphere showed a delay in color change with Hue values from about 130 to 120 under PMA against 130 to 100 in control group (CTR) leaves. Chlorophyll degradation was also delayed in both storage temperatures. Samples stored under PMA showed about two times the levels of total chlorophylls with respect to CTR samples at the end of the storage. No changes in total sugar content were detected during storage and no differences were detected between control and modified atmospheres stored samples. Samples maintained in a modified atmosphere showed a lower decrement in soluble proteins and a lower rate of RUBISCO degradation at both temperatures. The relation of RUBISCO content PMA/CTR ranged from 1 to about 3 toward the end of storage No changes in phenols content were found when comparing control and treated samples. However, flavonoid and the antioxidant contents increased in samples stored in modified atmospheres with respect to their controls. We demonstrated that storage in modified atmospheres could be an adequate and simple methodology to extend postharvest life of this minimally processed product at both ambient and refrigerated storage.

Published
2024
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50. Bio-Packaging Material Impact on Blueberries Quality Attributes under Transport and Marketing Conditions.

Author

Bof MJ, Laurent FE, Massolo F, Locaso DE, Versino F, and García MA

Abstract

Blueberries are highly appreciated for their high antioxidant content but are also particularly susceptible to fungal deterioration. In this work, corn starch and chitosan, byproducts of the fishing industry, as well as active compounds obtained from citrus processing waste were used to obtain active biodegradable film packaging. Blueberries were packed in corn starch-chitosan (CS:CH) films and in active films containing lemon essential oil (LEO) or grapefruit seed extract (GSE). The effects of film packaging on the quality parameters of berries and the fungal incidence of disease during storage were studied and compared to benchmark materials. A conservation assay simulating transport and commercialization conditions was conducted. Blueberries packed in CS:CH films showed antioxidant capacity values closer to those packed in commercial PET containers ( Clamshells ), preserving 84.8% of the initial antioxidants content. Fruit packed in LEO films exhibited the greatest weight loss and rot incidence, and poor surface color. CS:CH and GSE films controlled the fruit respiration rate and weight loss, therefore they are materials with adequate barrier properties for blueberries conservation. Bags formulated with GSE showed adequate barrier properties to maintain fruit quality attributes without the incidence of rottenness, being an interesting option for blueberries exportation.

Published
2021
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