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1. The potential utility of abbreviated breast MRI (FAST MRI) as a tool for breast cancer screening: a systematic review and meta-analysis

Author

Geach, R., primary, Jones, L.I., additional, Harding, S.A., additional, Marshall, A., additional, Taylor-Phillips, S., additional, McKeown-Keegan, S., additional, Dunn, J.A., additional, Kuhl, Christiane, additional, Vinnicombe, Sarah, additional, O'Flynn, Elizabeth, additional, Wookey, Jennifer, additional, Rose, Janice, additional, Foy, Christopher, additional, Taylor, Victoria, additional, Valencia, Alexandra, additional, Gifford, John, additional, Gray, Rosie, additional, Jones, Thomas William, additional, Litton, Karen, additional, Lloyd, Simon, additional, Kutt, Elisabeth, additional, Pocklington, Alice, additional, Mahatma, Anjum, additional, Massey, Helen, additional, Clark, Gillian, additional, McLachlan, Clare, additional, Beckett, Gemini, additional, Alison, Clare, additional, Barta, Miklos, additional, Betancourt, Claudia, additional, Bramwell, Julie, additional, Bright, Nichola, additional, Burt, Helen, additional, Cann, Louise, additional, Ceney, Jane, additional, Cornford, Eleanor, additional, Dalgliesh, Diana, additional, Doyle, Sarah, additional, Fearn, Sarah, additional, Godden, Dagmar, additional, Goldthorpe, Zoe, additional, Hobson, Lucinda, additional, Hynam, Paula, additional, Jackson, Emma, additional, Jenkin, Margaret, additional, Kingsnorth, Beckie, additional, Klimczak, Katherine, additional, Moody, Alice, additional, Perrin, Sarah, additional, Peters, Alison, additional, Preston, Elizabeth, additional, Ratsey, Anne, additional, Sidebottom, Richard, additional, Steel, Jim, additional, Stephenson, Lesley, additional, Taylor, Michelle, additional, Toth, Erika, additional, Vincent, Frances, additional, Watkin, Sharon, additional, Widdison, Sue, additional, Williams, Jennifer, additional, Wilmot, Karen, additional, Elangovan, Premkumar, additional, Halling-Brown, Mark, additional, Ghiasvand, Hesam, additional, Hulme, Claire, additional, Singamaneni, Sravya, additional, Friedrich, Zsolt, additional, Robson, Joanne, additional, and Mankelow, Anna, additional

Published
2021
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5. British Society of Breast Radiology Annual Scientific Meeting 2016

Author

Azmil, Ameerah Mohd, primary, Bansal, Gaurav Jyoti, additional, Davies, Eleri, additional, Wallis, Matthew, additional, Kilburn-Toppin, Fleur, additional, Taylor-Phillip, Sian, additional, Buckley, Anne, additional, Healy, Nuala, additional, Quinn, Aine, additional, O’Keeffe, Sylvia, additional, Ang, Teri, additional, Maxwell, Anthony, additional, Lim, Yit Y., additional, Harkness, Elaine, additional, Emsley, Richard, additional, Astley, Susan, additional, Gadde, Soujanya, additional, Ferguson, Jennifer, additional, Stevens, Guy, additional, Hills, Robert, additional, Thomas, Kate Gower, additional, Rajan, Sabrina, additional, Sharma, Nisha, additional, Kishore, Ajit, additional, O’ Dowd, John, additional, Murphy, Claire, additional, Lindsay, Ken, additional, Dadayal, Guneesh, additional, Moody, Anne Nielsen, additional, Whitaker, Madeleine, additional, Wolstenhulme, Stephen, additional, Bull, Jane, additional, Culpan, Anne-Marie, additional, Roszkowski, Natalia, additional, Grima, Alexis, additional, Stahnke, Michaela, additional, Rubin, Caroline, additional, Walker, Ruth, additional, Oeppen, Rachel, additional, Puttagunta, Srikanth, additional, Gray, Karen, additional, Puri, Shama, additional, Millican-Slater, Rebecca, additional, Pascaline, Sana, additional, Hajaj, Mohamad, additional, Flinn, Janet, additional, Thomson, Kim, additional, Elsberger, Beatrix, additional, Turnbull, Anne, additional, Bagnall, Mark, additional, York, Joanne, additional, Benney, Stuart, additional, Goyal, Amit, additional, Topps, Ashley, additional, Barr, Simon, additional, Pikoulas, Panagiotis, additional, Pritchard, Susan, additional, Greenhalgh, Sophie, additional, Sreenivas, Muthyala, additional, Nandhra, Anju, additional, Sharma, Sheetal, additional, Gulati, Archita, additional, Razzaq, Furhan, additional, Khan, Sana, additional, McKillen, Jacqueline, additional, Larkin, Rupert, additional, Kamat, Sachin, additional, Goncalves, Carla, additional, Tan, Alan, additional, Eleti, Asha, additional, Vidyaprakash, Nithya, additional, McMahon, Michelle A., additional, Dall, Barbara J. G., additional, Majid, Faisal, additional, Rattehalli, Ramachadra, additional, Gaur, Vandana, additional, Mackenzie, Alistair, additional, Warren, Lucy, additional, Patel, Mishal, additional, Halling-Brown, Mark, additional, Wilkinson, Louise, additional, Young, Kenneth, additional, Tanner, James, additional, Currie, Rachael, additional, Balyes, Sharron, additional, Wragg, Julie, additional, Zamfir, Georgiana, additional, Ayra, Pallavi, additional, Marsden, Max, additional, Butterworth, James, additional, Sinha, Shona, additional, Desai, Anil, additional, Metafa, Anna, additional, Nielsen-Moody, Anne, additional, Ward, Laura, additional, Heller, Samantha, additional, Hudson, Sue, additional, Taylor, Kathryn, additional, Xyda, Argyro, additional, Allen, Steven, additional, Orlowski, Elizabeth, additional, Downey, Kate, additional, Sidebottom, Richard, additional, Lodhi, Ahmad, additional, Howell, Anthony, additional, Evans, Gareth, additional, Lim, Yit, additional, Chen, Yan, additional, Lepine-Williams, Elizabeth, additional, Henderson, Steven, additional, Litherland, Janet, additional, Altaf, Naveed, additional, Bury, Yvonne, additional, Forester, Nerys, additional, Chin, Mei Chan, additional, Taylor, Caroline, additional, Skippage, Pippa, additional, Sian, Aneet, additional, McAvinchey, Rita, additional, Evans, Tom, additional, Nisbet, Sian, additional, Murray, Alex, additional, Castillo, Raquel Clark, additional, Markham, Hannah, additional, Thomas, Timothy, additional, Jain, Anil, additional, Molderson, Jaanilka, additional, Wan, Joseph, additional, Newman, Helen, additional, Lowes, Simon, additional, Lunt, Linsley, additional, Sultana, Sadia, additional, Chillal, Varun, additional, Dalton, Rebecca, additional, Reeves, David, additional, Sergeant, Jamie, additional, Edwards, Liz, additional, Jenkins, Kate, additional, Shaikh, Shaheeda, additional, O’Flynn, Elizabeth, additional, Bombroffe, Laura, additional, Hughes, Julie, additional, Scurr, Erica, additional, Wilson, Robin, additional, Jones, Lyn, additional, Govindarajulu, Sasirekha, additional, Sahu, Ajay K., additional, Brown, Matthew, additional, Allen, Steve, additional, O’Flynn, Liz, additional, deSouza, Nandita, additional, Rahim, Rumana, additional, Wasan, Rema, additional, Goligher, Jane, additional, Wijesuriya, Shalini, additional, Morel, Juliet, additional, Peacock, Clare, additional, Michell, Michael, additional, Iqbal, Asif, additional, Evans, David, additional, Batohi, Bhavna, additional, Wasan, Tavleen, additional, Phillips, Vivien, additional, Manuel, Eden, additional, Bowman, Gillian, additional, Satchithananda, Keshthra, additional, Fang, Cheng, additional, Shah, Chirag, additional, Hodkin, Leanne, additional, Horgan, Keiran, additional, Dodwell, David, additional, Moloney, BM, additional, Casey, M. C., additional, Breathnach, A., additional, Dwyer, R. M., additional, McLoughlin, R., additional, Sweeney, K. J., additional, Malone, C., additional, Healy, M. J., additional, Kerin, M. J., additional, Mitchell, Elizabeth, additional, Twiddy, Maureen, additional, Dobson, Hilary, additional, Vinnicombe, Sarah, additional, Evans, Andrew, additional, Grant, David, additional, Bishop, Briony, additional, Giggens, Roxanne, additional, Bhuva, Shaheel, additional, Royds, Jennifer, additional, Camilleri, Francesca, additional, Babu, Gauripriya, additional, Beveridge, Carolyn, additional, Geach, Rebecca, additional, Klimczak, Katherine, additional, Massey, Helen, additional, Lyburn, Iain, additional, Salehi-Bird, Seema, additional, Nishtala, Sahithi, additional, Gunning, Liz, additional, Changaradil, Deepthi Vinayan, additional, Bansal, Jyoti, additional, Davis, Joanna, additional, Sharma, Ashwini, additional, Del Voscovo, Elena, additional, Etheridge, Harriet, additional, Butler, Aisling, additional, Fenne, David S. J., additional, Rubin, Gary, additional, Burt, Helen, additional, Ridley, Nick, additional, Taylor, Sarah, additional, Seth, Subodh, additional, and Seth, Archana, additional

Published
2016
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9. Generating Human Osteoclasts In Vitro from Bone Marrow and Peripheral Blood.

Author

Walker, John M., Helfrich, Miep H., Ralston, Stuart H., Flanagan, Adrienne M., and Massey, Helen M.

Abstract

Osteoclasts derive from macrophage colony-stimulating factor (M-CSF)-dependent hemopoietic precursors that develop into cells that express the αvβ3 subunit of the vitronectin receptor (VNR) and the calcitonin receptor (CTR). The extracellular degradative process, known as bone resorption, is the hallmark of the osteoclast, and includes removal of both the hydroxyapatite and organic components of the skeleton. For bone resorption to occur, osteoclasts form a subcellular space, referred to as an extracellular lysosome, into which they secrete acid and enzymes when they come into contact with either calcified bone or dentine but not with plastic or uncalcified collagen-based matrices. This subcellular space is dependent upon the formation of a "tight seal" by the osteoclast, a process involving rearrangement of the cytoskeleton into a characteristic F-actin ring structure (see the chapter by Nesbitt and Horton, this volume, for details). [ABSTRACT FROM AUTHOR]

Published
2003
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10. Gastric Ulcer Healing

Author

Bardhan, K. D., primary, Walker, R., additional, Hinchliffe, C., additional, Bose, K., additional, Morris, Pamela, additional, Thompson, Mary, additional, Miller, J. P., additional, Toivanen, E., additional, Thompson, R. P. H., additional, Patrier, P., additional, Pikkarainen, P., additional, Keyrilainen, O., additional, Yli-Uotila, R., additional, Swan, C. H. J., additional, Klepping, C., additional, Tarpila, S., additional, Thomson, Moira H., additional, Harris, S., additional, Massey, Helen C., additional, and Ipe, D., additional

Published
1991
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11. British Society of Breast Radiology Annual Scientific Meeting 2016

Author

Azmil, Ameerah Mohd, Bansal, Gaurav Jyoti, Davies, Eleri, Wallis, Matthew, Kilburn-Toppin, Fleur, Taylor-Phillip, Sian, Buckley, Anne, Healy, Nuala, Quinn, Aine, O’Keeffe, Sylvia, Ang, Teri, Maxwell, Anthony, Lim, Yit Y., Harkness, Elaine, Emsley, Richard, Astley, Susan, Gadde, Soujanya, Ferguson, Jennifer, Stevens, Guy, Hills, Robert, Thomas, Kate Gower, Rajan, Sabrina, Sharma, Nisha, Kishore, Ajit, O’ Dowd, John, Murphy, Claire, Lindsay, Ken, Dadayal, Guneesh, Moody, Anne Nielsen, Whitaker, Madeleine, Wolstenhulme, Stephen, Bull, Jane, Culpan, Anne-Marie, Roszkowski, Natalia, Grima, Alexis, Stahnke, Michaela, Rubin, Caroline, Walker, Ruth, Oeppen, Rachel, Puttagunta, Srikanth, Gray, Karen, Puri, Shama, Millican-Slater, Rebecca, Pascaline, Sana, Hajaj, Mohamad, Flinn, Janet, Thomson, Kim, Elsberger, Beatrix, Turnbull, Anne, Bagnall, Mark, York, Joanne, Benney, Stuart, Goyal, Amit, Topps, Ashley, Barr, Simon, Pikoulas, Panagiotis, Pritchard, Susan, Greenhalgh, Sophie, Sreenivas, Muthyala, Nandhra, Anju, Sharma, Sheetal, Gulati, Archita, Razzaq, Furhan, Khan, Sana, McKillen, Jacqueline, Larkin, Rupert, Kamat, Sachin, Goncalves, Carla, Tan, Alan, Eleti, Asha, Vidyaprakash, Nithya, McMahon, Michelle A., Dall, Barbara J. G., Majid, Faisal, Rattehalli, Ramachadra, Gaur, Vandana, Mackenzie, Alistair, Warren, Lucy, Patel, Mishal, Halling-Brown, Mark, Wilkinson, Louise, Young, Kenneth, Tanner, James, Currie, Rachael, Balyes, Sharron, Wragg, Julie, Zamfir, Georgiana, Ayra, Pallavi, Marsden, Max, Butterworth, James, Sinha, Shona, Desai, Anil, Metafa, Anna, Nielsen-Moody, Anne, Ward, Laura, Heller, Samantha, Hudson, Sue, Taylor, Kathryn, Xyda, Argyro, Allen, Steven, Orlowski, Elizabeth, Downey, Kate, Sidebottom, Richard, Lodhi, Ahmad, Howell, Anthony, Evans, Gareth, Lim, Yit, Chen, Yan, Lepine-Williams, Elizabeth, Henderson, Steven, Litherland, Janet, Altaf, Naveed, Bury, Yvonne, Forester, Nerys, Chin, Mei Chan, Taylor, Caroline, Skippage, Pippa, Sian, Aneet, McAvinchey, Rita, Evans, Tom, Nisbet, Sian, Murray, Alex, Castillo, Raquel Clark, Markham, Hannah, Thomas, Timothy, Jain, Anil, Molderson, Jaanilka, Wan, Joseph, Newman, Helen, Lowes, Simon, Lunt, Linsley, Sultana, Sadia, Chillal, Varun, Dalton, Rebecca, Reeves, David, Sergeant, Jamie, Edwards, Liz, Jenkins, Kate, Shaikh, Shaheeda, O’Flynn, Elizabeth, Bombroffe, Laura, Hughes, Julie, Scurr, Erica, Wilson, Robin, Jones, Lyn, Govindarajulu, Sasirekha, Sahu, Ajay K., Brown, Matthew, Allen, Steve, O’Flynn, Liz, deSouza, Nandita, Rahim, Rumana, Wasan, Rema, Goligher, Jane, Wijesuriya, Shalini, Morel, Juliet, Peacock, Clare, Michell, Michael, Iqbal, Asif, Evans, David, Batohi, Bhavna, Wasan, Tavleen, Phillips, Vivien, Manuel, Eden, Bowman, Gillian, Satchithananda, Keshthra, Fang, Cheng, Shah, Chirag, Hodkin, Leanne, Horgan, Keiran, Dodwell, David, Moloney, BM, Casey, M. C., Breathnach, A., Dwyer, R. M., McLoughlin, R., Sweeney, K. J., Malone, C., Healy, M. J., Kerin, M. J., Mitchell, Elizabeth, Twiddy, Maureen, Dobson, Hilary, Vinnicombe, Sarah, Evans, Andrew, Grant, David, Bishop, Briony, Giggens, Roxanne, Bhuva, Shaheel, Royds, Jennifer, Camilleri, Francesca, Babu, Gauripriya, Beveridge, Carolyn, Geach, Rebecca, Klimczak, Katherine, Massey, Helen, Lyburn, Iain, Salehi-Bird, Seema, Nishtala, Sahithi, Gunning, Liz, Changaradil, Deepthi Vinayan, Bansal, Jyoti, Davis, Joanna, Sharma, Ashwini, Del Voscovo, Elena, Etheridge, Harriet, Butler, Aisling, Fenne, David S. J., Rubin, Gary, Burt, Helen, Ridley, Nick, Taylor, Sarah, Seth, Subodh, and Seth, Archana

Subjects
Medicine(all)
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12. An Agropolitan Line Study

Author

Massey, Helen Adair

Abstract

The rural section between the urban and agicultural regions of the Piedmont have many of the problems of both areas and the advantages of neither. Rural areas have long had a reputation for permitting land uses not tolerated in other vicinities. While attention has been focused on urban centers, rural regions have steadily declined for several decades. This thesis investigates the lifestyle and land use patterns of the Piedmont and the problems associated with them. For the purpose of this investigation, a section of a road in Pickens County northeast of the town of Six Mile was chosen as being typical of the rural part of the Piedmont region of the state. Each family living in this stretch of road was interviewed as part of the process of determining their lifestyles and residential needs. Such information as length of residency in an area, location of relatives, and number of acres owned by a family were found. Also, location of each family church, shopping points, and employment were plotted. The results of this investigation were compared to conclusions reached by others in similar surveys. From the interviews, it was determined that relationships to the land was important to the families interviewed. Land use from the history of settlement patterns in this country to present conditions in rural areas was analyzed. Upon investigation of current confliction uses of land in rural areas and lack of policies on rural land use, it was felt that this area of the thesis deserved the most attention. Current land uses policies across the country were researched and opinions were colicited from professionals in various fields in order to analyze the land use of the area under investigation as it applies to ther rural areas of Piedmont. The rural landscapes of the Piedmond is currently blighted by mobile homes and tar paper shacks. There has been an alarming increase in mobile homes in rural areas in recent years. Rural housing conditions are analyzed with an emphasis on mobile homes and the need the fulfill. Mobile homes are compared to conventional dwellings and are found to have high adaptive costs. Planning proposals for the area are suggested. Thus far, there has been an uncontrolled linear pattern of growth along rural roads. If the growth pattern is allowed to continue, all the land beside the roads will soon be built up and green spaces will be available only to those who boarder on them. Alternatives to the current trend, controlled linear and nucleated concepts are investigated. In the controlled linear concept, built-up areas are alternated with green spaces. In the nucleated concept houses are groups, thus facilitating economy in service. The nucleated concept contains a center of activity, or generator.

Published
1974

13. MARIA® M5: A multicentre clinical study to evaluate the ability of the Micrima radio-wave radar breast imaging system (MARIA®) to detect lesions in the symptomatic breast.

Author

Shere, Mike, Lyburn, Iain, Sidebottom, Richard, Massey, Helen, Gillett, Caroline, and Jones, Lyn

Subjects
*BREAST imaging, *IMAGING systems, *BREAST, *THREE-dimensional imaging, *ANTENNA arrays
Abstract

The MARIA® breast imaging system is a clinical diagnostic tool that uses a hemispherical array of radiowave antennas to generate three-dimensional images of the internal breast. The system utilises the variance of dielectric contrast within the breast volume in order to identify areas of interest for further diagnostic investigation. This multicentre study of 225 patients was conducted at three trial sites and recruited women with both malignant and benign lesions. The MARIA® images from the study were read by both clinicians who had access to the patient's clinical information, as well as by 'blind' reviewers who did not. Results from the study show an overall sensitivity of 76% for the system, which was similar across benign and malignant findings, and in denser breasts. The results from this study are outlined here and discussions on ongoing and future work with MARIA® are deliberated. [ABSTRACT FROM AUTHOR]

Published
2019
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14. MARIA ® M5: A multicentre clinical study to evaluate the ability of the Micrima radio-wave radar breast imaging system (MARIA ® ) to detect lesions in the symptomatic breast.

Author

Shere M, Lyburn I, Sidebottom R, Massey H, Gillett C, and Jones L

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Breast diagnostic imaging, Breast pathology, Breast Neoplasms pathology, Diagnosis, Differential, Female, Humans, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Young Adult, Breast Neoplasms diagnostic imaging, Diagnostic Imaging methods, Image Interpretation, Computer-Assisted methods, Imaging, Three-Dimensional methods, Radar
Abstract

The MARIA ® breast imaging system is a clinical diagnostic tool that uses a hemispherical array of radiowave antennas to generate three-dimensional images of the internal breast. The system utilises the variance of dielectric contrast within the breast volume in order to identify areas of interest for further diagnostic investigation. This multicentre study of 225 patients was conducted at three trial sites and recruited women with both malignant and benign lesions. The MARIA ® images from the study were read by both clinicians who had access to the patient's clinical information, as well as by 'blind' reviewers who did not. Results from the study show an overall sensitivity of 76% for the system, which was similar across benign and malignant findings, and in denser breasts. The results from this study are outlined here and discussions on ongoing and future work with MARIA ® are deliberated., (Copyright © 2019. Published by Elsevier B.V.)

Published
2019
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15. Upregulation of osteoclast alpha2beta1 integrin compensates for lack of alphavbeta3 vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia.

Author

Horton MA, Massey HM, Rosenberg N, Nicholls B, Seligsohn U, and Flanagan AM

Subjects
Adolescent, Adult, Aged, Bone Resorption etiology, Bone Resorption metabolism, Bone and Bones ultrastructure, Cells, Cultured, Child, Female, Humans, Male, Microscopy, Confocal, Microscopy, Electron, Scanning, Middle Aged, Osteoclasts physiology, Osteoclasts ultrastructure, Thrombasthenia complications, Thrombasthenia pathology, Integrin alpha2beta1 blood, Integrin alphaVbeta3 deficiency, Osteoclasts metabolism, Thrombasthenia blood, Up-Regulation
Abstract

Osteoclasts utilize alphavbeta3 integrin adhesion to bone matrix during bone resorption. We have generated osteoclasts from the peripheral blood of Iraqi-Jewish patients with Glanzmann thrombasthenia (GT) who are completely deficient in beta3 integrin and exhibit a haemorrhagic diathesis resulting from the absence of platelet alphaIIbbeta3. We show that, in contrast to osteoclasts generated from normal subjects or patients with alphaIIb integrin deficiency, GT osteoclasts lack alphavbeta3. These osteoclasts exhibited a two- to fourfold increase in alpha2 and beta1 integrin expression, whereas other alphav integrins, including alphavbeta5, were not significantly affected. An accompanying decrease in bone resorption was observed, with 44% and 59% declines in pit number and depth, respectively, and resorption lacunae showed abnormal morphology on scanning electron microscopy. However, osteoclasts from GT developed in similar numbers to controls and exhibited an otherwise 'normal' phenotype. We conclude that the observed rise in alpha2beta1 expression compensates for the chronic genetic deficiency of alphavbeta3 in osteoclasts from patients with GT and is sufficient to enable bone resorption to proceed, albeit to a submaximal extent. This explains why Iraqi-Jewish patients with GT do not have osteopetrosis.

Published
2003
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16. Generating human osteoclasts in vitro from bone marrow and peripheral blood.

Author

Flanagan AM and Massey HM

Subjects
Antigens, CD34 immunology, Bone Marrow Cells immunology, Carrier Proteins metabolism, Cell Culture Techniques methods, Humans, Interleukin-13 metabolism, Interleukin-4 metabolism, Leukocytes, Mononuclear immunology, Lipopolysaccharide Receptors immunology, Macrophage Colony-Stimulating Factor metabolism, Membrane Glycoproteins metabolism, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Transforming Growth Factor beta metabolism, Bone Marrow Cells physiology, Cell Differentiation physiology, Clinical Laboratory Techniques methods, Leukocytes, Mononuclear physiology, Osteoclasts physiology
Published
2003
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