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3. Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies

Author

Ruskovska, Tatjana, Budić-Leto, Irena, Corral-Jara, Karla Fabiola, Ajdžanović, Vladimir, Arola-Arnal, Anna, Bravo, Francisca Isabel, Deligiannidou, Georgia-Eirini, Havlik, Jaroslav, Janeva, Milkica, Kistanova, Elena, Kontogiorgis, Christos, Krga, Irena, Massaro, Marika, Miler, Marko, Milosevic, Verica, Morand, Christine, Scoditti, Egeria, Suárez, Manuel, Vauzour, David, and Milenkovic, Dragan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biotechnology, Complementary and Integrative Health, Nutrition, Clinical Research, Genetics, Aetiology, 2.1 Biological and endogenous factors, Generic health relevance, Cardiovascular, Good Health and Well Being, Adult, Cardiometabolic Risk Factors, Computational Biology, Female, Humans, Male, Metabolic Syndrome, MicroRNAs, Middle Aged, Nutrigenomics, Nutritional Physiological Phenomena, Polyphenols, Protective Agents, RNA, Messenger, Real-Time Polymerase Chain Reaction, Signal Transduction, systematic literature search, nutrigenomics, integrative bioinformatics, polyphenols, cardiometabolic health, human, Food Sciences, Nutrition and Dietetics, Clinical sciences, Nutrition and dietetics, Public health
Abstract

Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.

Published
2021

4. Omega‐3 polyunsaturated fatty acids and pulmonary arterial hypertension: Insights and perspectives.

Author

Massaro, Marika, Quarta, Stefano, Calabriso, Nadia, Carluccio, Maria Annunziata, Scoditti, Egeria, Mancuso, Peter, De Caterina, Raffaele, and Madonna, Rosalinda

Subjects
*UNSATURATED fatty acids, *PULMONARY arterial hypertension, *OMEGA-3 fatty acids, *LIFE expectancy, *MEDICAL research, *PULMONARY hypertension
Abstract

Pulmonary arterial hypertension (PAH) is a rare and progressive disorder that affects the pulmonary vasculature. Although recent developments in pharmacotherapy have extended the life expectancy of PAH patients, their 5‐year survival remains unacceptably low, underscoring the need for multitarget and more comprehensive approaches to managing the disease. This should incorporate not only medical, but also lifestyle interventions, including dietary changes and the use of nutraceutical support. Among these strategies, n‐3 polyunsaturated fatty acids (n‐3 PUFAs) are emerging as promising agents able to counteract the inflammatory component of PAH. In this narrative review, we aim at analysing the preclinical evidence for the impact of n‐3 PUFAs on the pathogenesis and the course of PAH. Although evidence for the role of n‐3 PUFAs deficiencies in the development and progression of PAH in humans is limited, preclinical studies suggest that these dietary components may influence several aspects of the pathobiology of PAH. Further clinical research should test the efficacy of n‐3 PUFAs on top of approved clinical management. These studies will provide evidence on whether n‐3 PUFAs can genuinely serve as a valuable tool to enhance the efficacy of pharmacotherapy in the treatment of PAH. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Exploring the Neuroprotective Potential of N-Methylpyridinium against LPS-Induced Neuroinflammation: Insights from Molecular Mechanisms.

Author

Giannotti, Laura, Di Chiara Stanca, Benedetta, Spedicato, Francesco, Stanca, Eleonora, Damiano, Fabrizio, Quarta, Stefano, Massaro, Marika, and Siculella, Luisa

Subjects
NEUROINFLAMMATION, INFLAMMATION, COFFEE beans, CELLULAR signal transduction, NEUROPROTECTIVE agents, NEUROLOGICAL disorders
Abstract

N-methylpyridinium (NMP) is produced through the pyrolysis of trigonelline during the coffee bean roasting process. Preliminary studies suggest that NMP may have health benefits, thanks to its antioxidant properties. Based on this background, the aim of this study was to evaluate whether NMP could have a protective effect against LPS-induced neuroinflammation in human glioblastoma cells (U87MG). With this aim, U87MG cells were pre-treated with NMP (0.5 μM) for 1 h and then exposed to LPS (1 μg/mL) for 24 h. Our findings show that NMP attenuates LPS-induced neuroinflammation by reducing the expression of pro-inflammatory cytokines, such as IL-1β, TNF-α and IL-6, through the inhibition of the NF-κB signaling pathway, which is critical in regulating inflammatory responses. NMP is able to suppress the activation of the NF-κB signaling pathway, suggesting its potential in preventing neuroinflammatory conditions. These outcomes support the notion that regular consumption of NMP, possibly through coffee consumption, may offer protection against neuroinflammatory states implicated in neurological disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Endothelial permeability, LDL deposition, and cardiovascular risk factors—a review

Author

Mundi, Santa, Massaro, Marika, Scoditti, Egeria, Carluccio, Maria Annunziata, van Hinsbergh, Victor WM, Iruela-Arispe, Marial Luisa, and De Caterina, Raffaele

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Atherosclerosis, Cardiovascular, Prevention, Genetics, Heart Disease, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Animals, Arteries, Biological Transport, Comorbidity, Endothelium, Vascular, Humans, Inflammation Mediators, Lipoproteins, LDL, Oxidative Stress, Permeability, Plaque, Atherosclerotic, Prognosis, Reactive Oxygen Species, Risk Factors, Signal Transduction, Smoking, Cardiovascular risk factors, Endothelium, Vascular permeability, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Early atherosclerosis features functional and structural changes in the endothelial barrier function that affect the traffic of molecules and solutes between the vessel lumen and the vascular wall. Such changes are mechanistically related to the development of atherosclerosis. Proatherogenic stimuli and cardiovascular risk factors, such as dyslipidaemias, diabetes, obesity, and smoking, all increase endothelial permeability sharing a common signalling denominator: an imbalance in the production/disposal of reactive oxygen species (ROS), broadly termed oxidative stress. Mostly as a consequence of the activation of enzymatic systems leading to ROS overproduction, proatherogenic factors lead to a pro-inflammatory status that translates in changes in gene expression and functional rearrangements, including changes in the transendothelial transport of molecules, leading to the deposition of low-density lipoproteins (LDL) and the subsequent infiltration of circulating leucocytes in the intima. In this review, we focus on such early changes in atherogenesis and on the concept that proatherogenic stimuli and risk factors for cardiovascular disease, by altering the endothelial barrier properties, co-ordinately trigger the accumulation of LDL in the intima and ultimately plaque formation.

Published
2018

8. Exploring the Relationship between Mediterranean Diet Adherence and Subjective Well-Being among Greek and Cypriot Adults.

Author

Deligiannidou, Georgia-Eirini, Philippou, Elena, Vasiari, Eirini, de Andrade, Vanda Lopes, Massaro, Marika, Chervenkov, Mihail, Ivanova, Teodora, Jorge, Rui, Dimitrova, Dessislava, Ruskovska, Tatjana, Miloseva, Lence, Maksimova, Viktorija, Smilkov, Katarina, Gjorgieva Ackova, Darinka, García-Conesa, María-Teresa, Pinto, Paula, and Kontogiorgis, Christos A.

Abstract

Associations between subjective well-being (SWB) and dietary habits, employment status, and habitual activities are increasingly capturing the focus of researchers as well as policymakers worldwide. This study aimed to explore these associations in a sample of the population in Greece and Cyprus via an online survey. In total, 936 questionnaires (470: Cyprus, 466: Greece) were analyzed to study the associations between the Mediterranean Diet (MD) (using the 14-item MEDAS score, (14-MEDAS)), subjective well-being (SWB), and several socioeconomic factors. Key remarks of this survey highlight the positive impact of MD adherence on some well-being items. Namely, statistically significant differences were found on the following items: Satisfied with life (p < 0.001), Life worthwhile (p < 0.001), Feeling happy (p < 0.001), worried (p = 0.005), and depressed (p = 0.001), when comparing Low MD adherence (14-MEDAS < 5) to High MD adherence (14-MEDAS > 10). Other lifestyle habits such as spending time with friends and family, spending time in nature, and habitual physical activity were associated with aspects of SWB such as Life satisfaction, Life worthwhile, Feeling happy, and energetic. The findings support adherence to the MD, since it is associated with higher life satisfaction and self-reported happiness in this sample and should be considered when developing health policies on well-being. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations

Author

Nikolic, Marina, Konic Ristic, Aleksandra, González-Sarrías, Antonio, Istas, Geoffrey, Urpi-Sarda, Mireia, Dall’Asta, Margherita, Monfoulet, Laurent-Emmanuel, Cloetens, Lieselotte, Bayram, Banu, Tumolo, Maria Rosaria, Chervenkov, Mihail, Scoditti, Egeria, Massaro, Marika, Tejera, Noemi, Abadjieva, Desislava, Chambers, Karen, Krga, Irena, Tomás-Barberán, Francisco A., Morand, Christine, Feliciano, Rodrigo, García-Villalba, Rocío, Garcia-Aloy, Mar, and Mena, Pedro

Published
2019
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12. Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes

Author

Carpi, Sara, primary, Quarta, Stefano, additional, Doccini, Stefano, additional, Saviano, Anella, additional, Marigliano, Noemi, additional, Polini, Beatrice, additional, Massaro, Marika, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Wabitsch, Martin, additional, Santorelli, Filippo Maria, additional, Cecchini, Marco, additional, Maione, Francesco, additional, Nieri, Paola, additional, and Scoditti, Egeria, additional

Published
2023
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14. Contributors

Author

Abete, Itziar, primary, Agirre, Xabier, additional, Ahlgren, Jennie, additional, Alkorta-Aranburu, Gorka, additional, Aller, Rocío, additional, Andres-Lacueva, Cristina, additional, Antonio de Luis, Daniel, additional, Babino, Darwin, additional, Bar-El Dadon, Shimrit, additional, Bonet, Maria Luisa, additional, Bordoni, Laura, additional, Borel, Patrick, additional, Bosch, Annet M., additional, Brown, Steven, additional, Busso, Dolores, additional, Calabriso, Nadia, additional, Capurso, Antonio, additional, Capurso, Cristiano, additional, Cariello, Marica, additional, Carluccio, Maria Annunziata, additional, Casas-Agustench, Patricia, additional, Cheatham, Carol L., additional, Chirita-Emandi, Adela, additional, Chittoor, Geetha, additional, Choi, Myung-Sook, additional, Choi, Sang-Woon, additional, Cordero, Paul, additional, Corrales, Fernando J., additional, Cortés, Víctor, additional, Cross, Nicholas C.P., additional, Crujeiras, Ana B., additional, Curi, Rui, additional, De Caterina, Raffaele, additional, de Lorenzo, David, additional, Desmarchelier, Charles, additional, Dong, Olivia, additional, Estruch, Ramón, additional, Ezponda, Teresa, additional, Fenech, Michael, additional, Ferguson, Lynnette R., additional, Fischer, Karina, additional, Fontana, Luigi, additional, Friso, Simonetta, additional, Gabbianelli, Rosita, additional, Garaulet, Marat, additional, Garcia-Irigoyen, Oihane, additional, Gil, Angel, additional, Gómez-Abellán, Purificación, additional, Görman, Ulf, additional, Harris, William S., additional, Hernandez-Vazquez, Alain de J., additional, Hugenholtz, Paul, additional, Hyde, Lara K., additional, Ibáñez, Clara, additional, Izaola, Olatz, additional, Jones, Peter J.H., additional, Kirwan, Richard, additional, Kohlmeier, Martin, additional, Krupenko, Natalia I., additional, Kwon, Eun-Young, additional, Lamming, Dudley W., additional, Lamuela-Raventos, Rosa M., additional, Langin, Dominique, additional, Langley-Evans, Simon, additional, Lira do Amaral, Cátia, additional, Lopez-Minguez, Jesus, additional, Madonna, Rosalinda, additional, Mansego, Maria L., additional, Marotz, Clarisse, additional, Martinez, J. Alfredo, additional, Massaro, Marika, additional, McRitchie, Susan, additional, Mesmar, Bayan, additional, Milagro, Fermín I., additional, Moreno-Aliaga, María J., additional, Moreno-Indias, Isabel, additional, Moschetta, Antonio, additional, Navas-Carretero, Santiago, additional, Niculescu, Mihai, additional, Nordström, Karin, additional, Novo, Francisco J., additional, Oben, Jude A., additional, Odriozola, Leticia, additional, Ordovas, Jose M., additional, Palou, Andreu, additional, Parslow, Virginia R., additional, Pathmasiri, Wimal, additional, Pérez-Castrillón, José Luis, additional, Pérusse, Louis, additional, Piccinin, Elena, additional, Plaza-Diaz, Julio, additional, Prósper, Felipe, additional, Qi, Lu, additional, Ralston, Jessica C., additional, Ramírez de Molina, Ana, additional, Rasti, George, additional, Reifen, Ram, additional, Renda, Giulia, additional, Riancho, José A., additional, Riancho del Moral, José Antonio, additional, Rivadeneira, Fernando, additional, Roche, Helen M., additional, Ruiz-Mambrilla, Marta, additional, Ruiz-Ojeda, Francisco Javier, additional, Salas-Pérez, Francisca, additional, San-Cristobal, Rodrigo, additional, Santander, Nicolás, additional, Santos, José L., additional, Saupe, Jörg, additional, Scoditti, Egeria, additional, Serhan, Charles N., additional, Simonet, Nicolas G., additional, Simopoulos, Artemis P., additional, Steinle, Nanette, additional, Sumner, Susan C.J., additional, Tinahones, Francisco J., additional, Vaquero, Alejandro, additional, Vazquez-Vidal, Itzel, additional, Velazquez-Arellano, Antonio, additional, Viguerie, Nathalie, additional, Vinciguerra, Manlio, additional, Visioli, Francesco, additional, Vizmanos, José L., additional, von Lintig, Johannes, additional, Voruganti, Venkata Saroja, additional, Wanders, Ronald J.A., additional, Wang, Tiange, additional, Wiltshire, Tim, additional, Yu, Deyang, additional, Zarrinpar, Amir, additional, Zeisel, Steven H., additional, and Zulet, Maria Angeles, additional

Published
2020
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16. Association between Mediterranean lifestyle and perception of well-being and distress in a sample population of university Italian students

Author

Quarta, Stefano, primary, Siculella, Luisa, additional, Levante, Annalisa, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Scoditti, Egeria, additional, Damiano, Fabrizio, additional, Lecciso, Flavia, additional, Pinto, Paula, additional, García-Conesa, María-Teresa, additional, Pollice, Fabio, additional, and Massaro, Marika, additional

Published
2023
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17. Blackcurrant Supplementation and Habitual Physical Activity Enhance Functional Capacity and Quality of Life in Previously Sedentary Older Women

Author

Chatzopoulou, Stefania, Dimitros, Eleftherios, Massaro, Marika, Cicchella, Antonio, Jamurtas, Athanasios, Kouidi, Evangelia, Tsiptsios, Dimitrios, Kenny, Glen P., and Kaltsatou, Antonia

Abstract

Background: Loss of functional capacity negatively impacts the quality of life in older adults. Objective: This single-site randomized controlled study examined whether short- (one week) and long-term (three months) blackcurrant supplementations combined with habitual physical activity would improve functional capacity and quality of life in previously sedentary older women.Methods: Thirty sedentary, healthy older women were randomly assigned to receive blackcurrant supplementation (400 mg of blackcurrant extract) (Polyphenol group, n=15; 74.2±10.0 years) or no supplementation (capsules of 400 mg of corn flour) (Placebo group, n=15; 72.8±8.7 years). Each group consumed two capsules daily for one week and three months, with a washout period of one week between the two phases. The polyphenol group was required to increase habitual activity levels. Participants underwent a functional capacity assessment consisting of a sixminute walk, sit-to-stand test, Berg balance scale measurement and quality of life evaluation with the Scale of Life Satisfaction Index (LSI) at the start, after one week, and after three months of supplementation.Results: Walking distance and time to sit-to-stand improved by 2.5% (p=0.005) and 7.5% (p=0.005), respectively, after one week in the polyphenol group. After 3 months, walking distance in the six-minute walk test increased by 12.3% (p=0.001) while the time to sit-to-stand decreased by 16% (p=0.002) in the polyphenol compared to placebo group, respectively. No differences in Berg balance scale were observed. Quality of life, indexed by LSI, improved by 39% (p=0.001) in the polyphenol compared to the placebo group.Conclusion: Blackcurrant supplementation, combined with habitual activity, may enhance functional capacity and quality of life in older women, offering a potential strategy to maintain independence. However, future studies should address longer durations to validate these findings.

Published
2024
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20. Association between Mediterranean lifestyle and perception of well-being and distress in a sample population of university Italian students

Author

Quarta, Stefano, Siculella, Luisa, Levante, Annalisa, Carluccio, Maria Annunziata, Calabriso, Nadia, Scoditti, Egeria, Damiano, Fabrizio, Lecciso, Flavia, Pinto, Paula, García-Conesa, María-Teresa, Pollice, Fabio, and Massaro, Marika

Abstract

We investigated the extent to which adherence to the Mediterranean diet (MD) in combination with Mediterranean lifestyle factors influenced students’ perceptions of subjective well-being (SWB) and distress. 939 undergraduates completed a survey to assess sociodemographic and lifestyle characteristics, including adherence to the MD, depression, anxiety, stress, and SWB. Data were analysed with correlation, logistic, and multiple linear regression models. Higher adherence to MD correlated with better SWB. Fruit, red meat, sweet and caffeinated beverages contributed significantly. However, it was the combination of adherence to MD with other factors, including quality of social relationships, income, smoking, sleep, and physical activity that better predicted SWB. Our results confirm the positive influence of MD on SWB. However, they also suggest the need to consider perceptions of well-being by a more holistic approach that considers physical and social factors simultaneously to improve the development of more effective educational and motivational programmes.

Published
2023
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21. Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast®, a Combination of Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis

Author

Quarta, Stefano, primary, Santarpino, Giuseppe, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Scoditti, Egeria, additional, Siculella, Luisa, additional, Damiano, Fabrizio, additional, Maffia, Michele, additional, Verri, Tiziano, additional, De Caterina, Raffaele, additional, and Massaro, Marika, additional

Published
2022
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24. Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans – Evidence from untargeted mRNA and miRNA studies

Author

Ruskovska, Tatjana, primary, Budić-Leto, Irena, additional, Corral-Jara, Karla Fabiola, additional, Ajdžanović, Vladimir, additional, Arola-Arnal, Anna, additional, Bravo, Francisca Isabel, additional, Deligiannidou, Georgia-Eirini, additional, Havlik, Jaroslav, additional, Janeva, Milkica, additional, Kistanova, Elena, additional, Kontogiorgis, Christos, additional, Krga, Irena, additional, Massaro, Marika, additional, Miler, Marko, additional, Harnafi, Hicham, additional, Milosevic, Verica, additional, Morand, Christine, additional, Scoditti, Egeria, additional, Suárez, Manuel, additional, Vauzour, David, additional, and Milenkovic, Dragan, additional

Published
2022
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27. Effect of Cocoa Products and Its Polyphenolic Constituents on Exercise Performance and Exercise-Induced Muscle Damage and Inflammation: A Review of Clinical Trials

Author

Massaro Marika, Egeria Scoditti, Maria Annunziata Carluccio, Antonia Kaltsatou, and Antonio Cicchella

Subjects
athlete, cocoa, chocolate, exercise performance, oxidative stress, performance, physical exercise, polyphenol, skeletal muscle, inflammation, Nutrition. Foods and food supply, TX341-641
Abstract

In recent years, the consumption of chocolate and, in particular, dark chocolate has been “rehabilitated” due to its high content of cocoa antioxidant polyphenols. Although it is recognized that regular exercise improves energy metabolism and muscle performance, excessive or unaccustomed exercise may induce cell damage and impair muscle function by triggering oxidative stress and tissue inflammation. The aim of this review was to revise the available data from literature on the effects of cocoa polyphenols on exercise-associated tissue damage and impairment of exercise performance. To this aim, PubMed and Web of Science databases were searched with the following keywords: “intervention studies”, “cocoa polyphenols”, “exercise training”, “inflammation”, “oxidative stress”, and “exercise performance”. We selected thirteen randomized clinical trials on cocoa ingestion that involved a total of 200 well-trained athletes. The retrieved data indicate that acute, sub-chronic, and chronic cocoa polyphenol intake may reduce exercise-induced oxidative stress but not inflammation, while mixed results are observed in terms of exercise performance and recovery. The interpretation of available results on the anti-oxidative and anti-inflammatory activities of cocoa polyphenols remains questionable, likely due to the variety of physiological networks involved. Further experimental studies are mandatory to clarify the role of cocoa polyphenol supplementation in exercise-mediated inflammation.

Published
2019
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28. Assessment of Subjective Well-Being in a Cohort of University Students and Staff Members: Association with Physical Activity and Outdoor Leisure Time during the COVID-19 Pandemic

Author

Quarta, Stefano, primary, Levante, Annalisa, additional, García-Conesa, María-Teresa, additional, Lecciso, Flavia, additional, Scoditti, Egeria, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Damiano, Fabrizio, additional, Santarpino, Giuseppe, additional, Verri, Tiziano, additional, Pinto, Paula, additional, Siculella, Luisa, additional, and Massaro, Marika, additional

Published
2022
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31. Exploring Hedonic and Eudaimonic Items of Well-Being in Mediterranean and Non-Mediterranean Countries: Influence of Sociodemographic and Lifestyle Factors

Author

Andrade, Vanda, primary, Quarta, Stefano, additional, Tagarro, Marta, additional, Miloseva, Lence, additional, Massaro, Marika, additional, Chervenkov, Mihail, additional, Ivanova, Teodora, additional, Jorge, Rui, additional, Maksimova, Viktorija, additional, Smilkov, Katarina, additional, Ackova, Darinka Gjorgieva, additional, Ruskovska, Tatjana, additional, Philippou, Elena, additional, Deligiannidou, Georgia Eirini, additional, Kontogiorgis, Christos A., additional, Conesa, María-Teresa García, additional, and Pinto, Paula, additional

Published
2022
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34. Coffee Bioactive N-Methylpyridinium Attenuates Tumor Necrosis Factor (TNF)-α-Mediated Insulin Resistance and Inflammation in Human Adipocytes

Author

Quarta, Stefano, primary, Scoditti, Egeria, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Santarpino, Giuseppe, additional, Damiano, Fabrizio, additional, Siculella, Luisa, additional, Wabitsch, Martin, additional, Verri, Tiziano, additional, Favari, Claudia, additional, Del Rio, Daniele, additional, Mena, Pedro, additional, De Caterina, Raffaele, additional, and Massaro, Marika, additional

Published
2021
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36. Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast ® , a Combination of Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis

Author

Quarta, Stefano, Santarpino, Giuseppe, Carluccio, Maria Annunziata, Calabriso, Nadia, Scoditti, Egeria, Siculella, Luisa, Damiano, Fabrizio, Maffia, Michele, Verri, Tiziano, De Caterina, Raffaele, and Massaro, Marika

Subjects
TURMERIC, PLANT extracts, BROMELIN, BOSWELLIA, TRANSFORMING growth factors, CARTILAGE cells, OSTEOARTHRITIS, ENDOTHELIAL cells
Abstract

Osteoarthritis (OA) is a joint disease characterized by inflammation of the synovium, angiogenesis, cartilage degradation, and osteophyte formation. Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum) are plants which extracts, together to Bromelain and Escin (Aesculus hippocastanum) are traditionally used in OA. However, their mechanistic role remains unclear. We aimed to investigate whether these bioactives alone or in combination (as in Flonat Fast®) can suppress TNF-α-induced inflammation, angiogenesis, and osteophyte formation using two cell models involved in OA: endothelial cells and monocytes. Each plant extract was evaluated for its polyphenol content, antioxidant activity, and toxicity. In endothelial cells and monocytes, expression of genes involved in OA was assessed, functional assays for inflammation and angiogenesis were performed, and impairment of reactive oxygen species production (ROS) was evaluated. Exposure of cells to the bioactives alone and in combination before cytokine stimulation resulted in differential counterregulation of several gene and protein expressions, including those for cyclooxygenases-2, metalloproteinase-9, transforming growth factor β1, and bone morphogenic protein-2. We demonstrated that these bioactives modulated monocyte adhesion to endothelial cells as well as cell migration and endothelial angiogenesis. Consistent with radical scavenging activity in the cell-free system, the bioactives curbed TNF-α-stimulated intracellular ROS production. We confirmed the potential anti-inflammatory and antiangiogenic effects of the combination of Harpagophytum procumbens, Boswellia, Curcuma, Bromelain, and Escin and provided new mechanistic evidence for their use in OA. However, further clinical studies are needed to evaluate the true clinical utility of these bioactives as supportive, preventive, and therapeutic agents. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Contributors

Author

Agudo, Antonio, primary, Alarcón, Marisa, additional, Aldasoro, Juan José, additional, Antonopoulou, Smaragdi, additional, Arnoni, Yardena, additional, Arranz, Sara, additional, Atteia, Hebatallah Husseini, additional, Azzini, Elena, additional, Badimon, Lina, additional, Bastida, Sara, additional, Beccari, Giovanni, additional, Berry, Elliot M., additional, Biandolino, Francesca, additional, Bonaccio, Marialaura, additional, Bonachela, Santiago, additional, Bonanni, Americo, additional, Bosco, Gerardo, additional, Buckland, Genevieve, additional, Calabriso, Nadia, additional, Caliskan, Oguzhan, additional, Carluccio, Maria Annunziata, additional, Casas, J. Jesús, additional, Casas, Rosa, additional, Castro-Quezada, Itandehui, additional, Chiva-Blanch, Gemma, additional, Conti, Gea Oliveri, additional, Copat, Chiara, additional, Couture, Patrick, additional, Covarelli, Lorenzo, additional, De Caterina, Raffaele, additional, De Feo, Vincenzo, additional, de Gaetano, Giovanni, additional, de Lorgeril, Michel, additional, De Martino, Laura, additional, Demetriou, Christiana A., additional, Detopoulou, Paraskevi, additional, Diamantopoulos, Emmanuel J., additional, Djuric, Zora, additional, Donati, Maria Benedetta, additional, Doreste-Alonso, Jorge, additional, El Rhazi, Karima, additional, El-Swefy, Sahar Elsayed, additional, Rodilla, Manuel Espárrago, additional, Estruch, Ramon, additional, Fallico, Roberto, additional, Farajian, Paul, additional, Fenoy, Encarnación, additional, Fernandez, J.M., additional, Fernandez, Maria Luz, additional, Fernández-Real, José Manuel, additional, Ferrante, Margherita, additional, Fragopoulou, Elizabeth, additional, Fuentes-Jimenez, F., additional, Gaforio, José J., additional, Garaulet, Marta, additional, Garcia-Larsen, Vanessa, additional, Gardener, Hannah, additional, Gesteiro, Eva, additional, Goldstein, Mark R., additional, González, Carlos A., additional, Gouveri, Evanthia, additional, Granados, Sergio, additional, Grimaldi, Keith, additional, Hadjisavvas, Andreas, additional, Henríquez-Sánchez, Patricia, additional, Hernández, Joaquín, additional, Iacoviello, Licia, additional, Iriti, Marcello, additional, Karageorgou, Dimitra, additional, Kontou, Niki, additional, Kyriacou, Kyriacos, additional, La Torre, Giuseppe, additional, Lairon, Denis, additional, Lamarche, Benoît, additional, Lee, Jaime, additional, Loizidou, Maria A., additional, López-Biedma, Alicia, additional, Macpherson, Helen, additional, Maiani, Giuseppe, additional, Mancini, Emilia, additional, Martin, Colin R., additional, Martínez-González, Miguel Ángel, additional, Mascitelli, Luca, additional, Massaro, Marika, additional, Medina, F. Xavier, additional, Mendieta, Guiomar, additional, Mesías, Marta, additional, Micha, Renata, additional, Moreno-Navarrete, José María, additional, Moyano, Francisco J., additional, Navarro, M. Pilar, additional, Nazzaro, Filomena, additional, Nejjari, Chakib, additional, Nilsson, Lena Maria, additional, Nomikos, Tzortzis, additional, Oliviero, Francesca, additional, Erdogan Orhan, Ilkay, additional, Paoli, Antonio, additional, Papandreou, Christopher, additional, Pase, Matthew, additional, Pellegrino, Mariangela, additional, Pipingas, Andrew, additional, Potenza, Concetta, additional, Prato, Ermelinda, additional, Preedy, Victor R., additional, Pulido-Moran, Mario, additional, Punzi, Leonardo, additional, Quiles, José L., additional, Ramírez-Tortose, Ma del Carmen, additional, Richard, Caroline, additional, Rodríguez Bernal, Beatriz, additional, Román-Viñas, Blanca, additional, Ros, Emilio, additional, Rosado-Alvarez, D., additional, Ríos, José-Luis, additional, Ruano, Cristina, additional, Sahingoz, Semra Akar, additional, Salen, Patricia, additional, Sánchez Benito, José L., additional, Soriano, Eva Sánchez, additional, Sánchez-Muniz, Francisco J., additional, Sánchez-Quesada, Cristina, additional, Sánchez-Villegas, Almudena, additional, Saulle, Rosella, additional, Scholey, Andrew, additional, Sciacca, Salvatore, additional, Scoditti, Egeria, additional, Seiquer, Isabel, additional, Semyonov, Leda, additional, Serra-Majem, Lluís, additional, Sewell, Dean A., additional, Sfriso, Paolo, additional, Sheikh, Aziz, additional, Skroza, Nevena, additional, Spinella, Paolo, additional, Tosi, Laura, additional, Tumen, Ibrahim, additional, Valderas-Martinez, Palmira, additional, Varoni, Elena M., additional, Vilahur, Gemma, additional, Villalon, Lorena, additional, Villarroya, Gemma Xifra, additional, Vineis, Paolo, additional, Warleta, Fernando, additional, Wright, Clinton B., additional, Zacharski, Leo R., additional, Zampelas, Antonis, additional, and Zuber, Sara, additional

Published
2015
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38. Mediterranean Diet Polyphenols

Author

Carluccio, Maria Annunziata, primary, Calabriso, Nadia, additional, Scoditti, Egeria, additional, Massaro, Marika, additional, and De Caterina, Raffaele, additional

Published
2015
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39. Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies

Author

Monfoulet, Laurent‐Emmanuel, primary, Ruskovska, Tatjana, additional, Ajdžanović, Vladimir, additional, Havlik, Jaroslav, additional, Vauzour, David, additional, Bayram, Banu, additional, Krga, Irena, additional, Corral‐Jara, Karla‐Fabiola, additional, Kistanova, Elena, additional, Abadjieva, Desislava, additional, Massaro, Marika, additional, Scoditti, Egeria, additional, Deligiannidou, Eirini, additional, Kontogiorgis, Christos, additional, Arola‐Arnal, Anna, additional, Schothorst, Evert M., additional, Morand, Christine, additional, and Milenkovic, Dragan, additional

Published
2021
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40. List of Contributors

Author

Aguiar, Odair, primary, Alkholy, Sarah Omar, additional, Allgrove, Judith, additional, Alqahtani, Samiah Naji, additional, Amini, Anna, additional, de Mello Andrade, Juliana Maria, additional, Andres-Lacueva, Cristina, additional, Aquilato, Andrea, additional, Arora, Rajesh, additional, Arranz, Sara, additional, Ashida, Hitoshi, additional, Avena, Paola, additional, Badole, Sachin L., additional, Baer-Dubowska, Wanda, additional, Bahrim, Gabriela, additional, Baliga, Manjeshwar Shrinath, additional, Barnes, Stephen, additional, Batista, Maria T., additional, Berhanu, Workalemahu Mikre, additional, Bhatia, Alka, additional, Bodhankar, Subhash L., additional, Bodnar, Lubomir, additional, Bolca, Selin, additional, Boto-Ordoñez, Maria, additional, Brizuela, Leyre, additional, Calhau, Conceição, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pozo, Catalina, additional, Caruso, Anna, additional, Casaburi, Ivan, additional, Castro, Gerardo D., additional, Castro, José A., additional, Celep, Gulcin Sagdicoglu, additional, Chacko, Amala, additional, Chaudhari, Swapnil M., additional, Chen, Chung-Hwan, additional, Chen, Lixia, additional, Chiva-Blanch, Gemma, additional, Christensen, Kathrine Bisgaard, additional, Christensen, Lars Porskjær, additional, Chyu, Ming-Chien, additional, Cordova, Felina M., additional, Corona, Giulia, additional, Costa, G., additional, Cress, Brady F., additional, Crozier, Stephen J., additional, Cruz, M.T., additional, Cuvillier, Olivier, additional, Čvorović, Jovana, additional, Cyr, Lisa Danielle, additional, Czank, Charles, additional, D’Archivio, Massimo, additional, Davison, Glen, additional, De Caterina, Raffaele, additional, Deng, Guifang, additional, Devkar, Ranjitsinh V., additional, Doo, Taisha, additional, Doonan, Barbara, additional, Emami, Seyed Ahmad, additional, Estruch, Ramón, additional, Virgili, Fabio, additional, Falk, Michael, additional, Faria, Ana, additional, Farina, Grazia, additional, Fasolo, Daniel, additional, Fayad, Raja, additional, Ferreira, Maria Pontes, additional, Ferri, Claudio, additional, Forester, Sarah C., additional, Fornasaro, Stefano, additional, Cimino, Francesco, additional, Francis, Atul, additional, Francisco, V., additional, Fukuda, Itsuko, additional, Garcia-Aloy, Mar, additional, García-Mediavilla, María Victoria, additional, Gendron, Fidji, additional, Ghantasala, S., additional, Gil-Becerra, David, additional, Giovannini, Claudio, additional, Givigliano, Francesco, additional, Goldstein, Mark R., additional, Goel, Ajay, additional, Gollücke, Andréa Pittelli Boiago, additional, González-Gallego, Javier, additional, Govindaraghavan, Suresh, additional, Grassi, Davide, additional, Gunawardena, Dhanushka, additional, Guo, Honghui, additional, Habauzit, Véronique, additional, Haegeman, Guy, additional, He, Xiran, additional, Hegde, Mahabaleshwar V., additional, Heyninck, Karen, additional, Hsieh, Tze-chen, additional, Hurst, W. Jeffrey, additional, Iemma, Francesca, additional, Igoe, Ann, additional, Iglesias, Jacobo, additional, Ikeda, Ikuo, additional, Jadeja, Ravirajsinh N., additional, Jaffe, Russell, additional, Janda, Elzbieta, additional, Janel, Nathalie, additional, Jangam, Ganesh B., additional, Jayachander, Dipika, additional, Jiang, Fan, additional, Jirillo, Emilio, additional, Joo, Eun Ji, additional, Joseph, Nadhini, additional, Aguiar, Odair, additional, Juturu, Vijaya, additional, Kalekhan, Faizan, additional, Kamath, Krithika, additional, Karana, Rita, additional, Kaur, Kamaljeet, additional, Keating, Elisa, additional, Kennedy, David O., additional, Kerr, Jason, additional, Khaled, Mohd, additional, Khoo, Christina, additional, Khymenets, Olha, additional, Kim, Jiyoung, additional, Kobayashi, Makoto, additional, Kobori, Masuko, additional, Kochikuzhyil, Benson Mathai, additional, Koffas, Mattheos A.G., additional, Korniluk, Jan, additional, Kumar, Ashish, additional, Kumar, G., additional, Kumar, Yashwant, additional, Kumazawa, Yosho, additional, Kurien, Biji T., additional, Kwun, In-Sook, additional, Lambert, Joshua D., additional, Lamuela-Raventos, Rosa Maria, additional, Latheef, Latheesh, additional, Lee, Hyong Joo, additional, Lee, Ki Won, additional, Li, Huabin, additional, Li, Sha, additional, Llorach, Rafael, additional, Lopez, Victoria, additional, Maciel, María E., additional, Magrone, Thea, additional, Mani, Jayashree, additional, Marotta, Francesco, additional, Marquardt, Kristen Conrad, additional, Martel, Fátima, additional, Martínez, Verónica, additional, Maru, Girish B., additional, Mascitelli, Luca, additional, Masella, Roberta, additional, Maskarinec, Gertraud, additional, Massaro, Marika, additional, Masunov, Artëm E., additional, Mathew, Geetha, additional, Medina, Isabel, additional, Medina-Remón, Alexander, additional, Menaa, Abder, additional, Menaa, Bouzid, additional, Menaa, Farid, additional, Miglio, C., additional, Milenkovic, Dragan, additional, Mitjans, Montserrat, additional, Miura, Tomisato, additional, Mo, Huanbiao, additional, Mollace, Vincenzo, additional, Morand, Christine, additional, Moribito, G., additional, Mudgal, Piya Paul, additional, Münch, Gerald, additional, Murakami, Akira, additional, Nagasako-Akazome, Yoko, additional, Nayak, Yogendra, additional, Neves, B.M., additional, Noll, Christophe, additional, Nowak, Renata, additional, Nowacka, Natalia, additional, Odendaal, Antoinette Y., additional, Olech, Marta, additional, Ong, Khang Wei, additional, Osakabe, Naomi, additional, Paluszczak, Jarosław, additional, Parisi, Ortensia Ilaria, additional, Passamonti, Sabina, additional, Patil, Kalyani Y., additional, Pazos, Manuel, additional, Peluso, I., additional, Petry, Nicolai, additional, Pezzi, Vincenzo, additional, Piantanida, Marta, additional, Picci, Nevio, additional, Pimple, Bhushan P., additional, Pinto, John Thomas, additional, Pires, Vanessa Cardoso, additional, Prasain, Jeevan K., additional, Pravettoni, Valerio, additional, Primavesi, Laura, additional, Puoci, Francesco, additional, Quintans, Leandro N., additional, Rabassa, Montse, additional, Rai, Prajwith, additional, Rajeev, Antappa Govindaraju, additional, Rao, Suresh, additional, Rapeanu, Gabriela, additional, Rastmanesh, Reza, additional, Ravi, Rithin, additional, Restuccia, Donatella, additional, Ribeiro, Daniel Araki, additional, Rodrigo, Ramón, additional, Rotches-Ribalta, Maria, additional, Rouhani, Mae Nicole, additional, Saldanha, Elroy, additional, Saija, Antonella, additional, Sánchez-Campos, Sonia, additional, Saxena, Arpit, additional, Scazzocchio, Beatrice, additional, Schauss, Alexander G., additional, Scoditti, Egeria, additional, Scofield, R. Hal, additional, Serafini, Mauro, additional, Sharma, Rakesh, additional, Shen, Chwan-Li, additional, Shende, Pankaj S., additional, Shetty, Vaishaka, additional, Shivashankara, Arnadi Ramachandrayya, additional, Shoji, Toshihiko, additional, Simon, Paul, additional, Sinicropi, Maria Stefania, additional, Smith, Brenda J, additional, Sony, Dargi, additional, Speciale, Antonio, additional, Spencer, Jeremy P.E., additional, Stalmach, Angélique, additional, Stanciuc, Nicoleta, additional, Stover, Mitchel G, additional, Synowiec, Agnieszka, additional, Szarlej-Wcislo, Katarzyna, additional, Tajpara, P., additional, Tan, Benny Kwong Huat, additional, Tao, Ling, additional, Tayarani-Najaran, Nilufar, additional, Tayarani-Najaran, Zahra, additional, Thilakchand, Karadka Ramdas, additional, Tomás-Barberán, Francisco A., additional, Tomás-Navarro, María, additional, Tramer, Federica, additional, Tresserra-Rimbau, Anna, additional, Tréton, Jacques, additional, Tulipani, Sara, additional, Tuñón, María J., additional, Unnikrishnan, Mazhuvancherry K., additional, Urpi-Sarda, Mireia, additional, Valderas-Martínez, Palmira, additional, Vallejo, Fernando, additional, Vauzour, David, additional, Vázquez-Fresno, Rosa, additional, Venkatesh, Ponemone, additional, Veerapur, Veeresh, additional, Vinardell, M. Pilar, additional, Walker, Ross, additional, Watson, Ronald R., additional, Wcislo, Gabriel, additional, Wightman, Emma L., additional, Wilkins, John, additional, Wu, Erxi, additional, Wu, Joseph M, additional, Wu, Shan, additional, Xia, Enqin, additional, Xia, Min, additional, Yajima, Hiroaki, additional, Zanwar, Anand A., additional, and Ziberna, Lovro, additional

Published
2014
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42. Angiogenic Properties of Concentrated Growth Factors (CGFs): The Role of Soluble Factors and Cellular Components

Author

Calabriso, Nadia, primary, Stanca, Eleonora, additional, Rochira, Alessio, additional, Damiano, Fabrizio, additional, Giannotti, Laura, additional, Di Chiara Stanca, Benedetta, additional, Massaro, Marika, additional, Scoditti, Egeria, additional, Demitri, Christian, additional, Nitti, Paola, additional, Palermo, Andrea, additional, Siculella, Luisa, additional, and Carluccio, Maria Annunziata, additional

Published
2021
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44. Persistent Moderate-to-Weak Mediterranean Diet Adherence and Low Scoring for Plant-Based Foods across Several Southern European Countries: Are We Overlooking the Mediterranean Diet Recommendations?

Author

Quarta, Stefano, primary, Massaro, Marika, additional, Chervenkov, Mihail, additional, Ivanova, Teodora, additional, Dimitrova, Dessislava, additional, Jorge, Rui, additional, Andrade, Vanda, additional, Philippou, Elena, additional, Zisimou, Constantinos, additional, Maksimova, Viktorija, additional, Smilkov, Katarina, additional, Ackova, Darinka Gjorgieva, additional, Miloseva, Lence, additional, Ruskovska, Tatjana, additional, Deligiannidou, Georgia Eirini, additional, Kontogiorgis, Christos A., additional, Sánchez-Meca, Julio, additional, Pinto, Paula, additional, and García-Conesa, María-Teresa, additional

Published
2021
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45. Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults

Author

Andrade, Vanda, primary, Jorge, Rui, additional, García-Conesa, María-Teresa, additional, Philippou, Elena, additional, Massaro, Marika, additional, Chervenkov, Mihail, additional, Ivanova, Teodora, additional, Maksimova, Viktorija, additional, Smilkov, Katarina, additional, Ackova, Darinka Gjorgieva, additional, Miloseva, Lence, additional, Ruskovska, Tatjana, additional, Deligiannidou, Georgia Eirini, additional, Kontogiorgis, Christos A., additional, and Pinto, Paula, additional

Published
2020
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46. Homocysteine induces VCAM-1 gene expression through NF-[kappa]B and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants

Author

Carluccio, Maria Annunziata, Ancora, Maria Assunta, Massaro, Marika, Carluccio, Marisa, Scoditti, Egeria, Distante, Alessandro, Storelli, Carlo, and De Caterina, Raffaele

Subjects
Hyperhomocysteinemia -- Research, Blood circulation disorders -- Risk factors, Gene expression -- Research, DNA binding proteins -- Research, Polyphenols -- Research, Biological sciences
Abstract

Hyperhomocysteinemia is a recognized risk factor for vascular disease, but pathogenetic mechanisms involved in its vascular actions are largely unknown. Because VCAM-1 expression is crucial in monocyte adhesion and early atherogenesis, we evaluated the NF-[kappa]B-related induction of VCAM-1 by homocysteine (Hey) and the possible inhibitory effect of dietary polyphenolic antioxidants, such as trans-resveratrol (RSV) and hydroxytyrosol (HT), which are known inhibitors of NF-[kappa]B-mediated VCAM-1 induction. In human umbilical vein endothelial cells (HUVEC), Hey, at 100 [micro]mol/1, but not cysteine, induced VCAM-1 expression at the protein and mRNA levels, as shown by enzyme immunoassay and Northern analysis, respectively. Transfection studies with deletional VCAM-1 promoter constructs demonstrated that the two tandem NF-[kappa]B motifs in the VCAM-1 promoter are necessary for Hey-induced VCAM-1 gene expression. Hcy-induced NF-[kappa]B activation was confirmed by EMSA, as shown by the nuclear translocation of its p65 (RelA) subunit and the degradation of the inhibitors I[kappa]B-[alpha] and I[kappa]B-[beta] by Western analysis. Hcy also increased intracellular reactive oxygen species by NAD(P)H oxidase activation, as shown by the membrane translocation of its [p47.sup.phox] subunit. NF-[kappa]B inhibitors decreased Hey-induced intracellular reactive oxygen species and VCAM-1 expression. Finally, we found that nutritionally relevant concentrations of RSV and HT, but not folate and vitamin B6, reduce (by >60% at [10.sup.-6] mol/1) Hcy-induced VCAM-1 expression and monocytoid cell adhesion to the endothelium. These data indicate that pathophysiologically relevant Hcy concentrations induce VCAM-1 expression through a prooxidant mechanism involving NF-[kappa]B. Natural Mediterranean diet antioxidants can inhibit such activation, suggesting their possible therapeutic role in Hey-induced vascular damage. atherosclerosis; endothelial activation; homocysteine; gene expression; inflammation; nuclear factor-[kappa]B

Published
2007

48. Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region

Author

García-Conesa, María-Teresa, primary, Philippou, Elena, additional, Pafilas, Christos, additional, Massaro, Marika, additional, Quarta, Stefano, additional, Andrade, Vanda, additional, Jorge, Rui, additional, Chervenkov, Mihail, additional, Ivanova, Teodora, additional, Dimitrova, Dessislava, additional, Maksimova, Viktorija, additional, Smilkov, Katarina, additional, Ackova, Darinka Gjorgieva, additional, Miloseva, Lence, additional, Ruskovska, Tatjana, additional, Deligiannidou, Georgia Eirini, additional, Kontogiorgis, Christos A., additional, and Pinto, Paula, additional

Published
2020
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49. Leptin and exercise: an update

Author

Cicchella, Antonio, primary, Carluccio, Maria, additional, Scoditti, Egeria, additional, Kaltsatou, Antonio, additional, and Massaro, Marika, additional

Published
2020
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50. List of Contributors

Author

Abia, Rocio, primary, Aguila, Marcia Barbosa, additional, Alcaraz, Miguel, additional, Aldini, Giancarlo, additional, Alonso, Alvaro, additional, de Cienfuegos, Gerardo Álvarez, additional, Amaral, Joana S., additional, Amirante, Paolo, additional, Amores, Victoria, additional, Amoruso, Angela, additional, Andrade, Paula B., additional, Andreadou, I., additional, Angioni, Alberto, additional, Ankan, Aysun, additional, Antunes, Lusânia Maria Greggi, additional, Apetrei, C., additional, Aramendía, María A., additional, Arbones-Mainar, Jose Miguel, additional, Arias, José L., additional, Arienti, Giuseppe, additional, Armenta, Sergio, additional, Assy, Nimmer, additional, Audi, Nama’a, additional, Azadmard-Damirchi, Sodeif, additional, Azqueta, Amaia, additional, Badiu, Diana, additional, Ballabio, Davide, additional, Balesteros, Manoela Ruchiga, additional, Ballesteros, Evaristo, additional, Barbosa, Décio Sabbatini, additional, Barbouti, Alexandra, additional, Bardelli, Claudio, additional, Batanero, Eva, additional, Baumann, Leslie, additional, Benavente-García, Obdulio, additional, Becker, Peter, additional, Bendini, Alessandra, additional, Benedetti, Simona, additional, Beretta, Giangiacomo, additional, Bermudez, Beatriz, additional, Bes-Rastrollo, Maira, additional, Bianchi, Maria de Lourdes Pires, additional, Bisignano, Giuseppe, additional, Blanco, Santos, additional, Boskou, George, additional, Bracci, Tania, additional, Bravo, Laura, additional, Brenes, Manuel, additional, Brescia, Maria Antonietta, additional, Briasoulis, Evangelos, additional, Brunelleschi, Sandra, additional, Bucci, Remo, additional, Buckland, Genevieve, additional, Buratti, Susanna, additional, Buróníó, María I., additional, Busconi, Matteo, additional, Cabello-Moruno, Rosana, additional, Caboni, Pierluigi, additional, Cabras, Paolo, additional, Caggia, Cinzia, additional, Camuesco, Desiree, additional, Cancelas, Jesús, additional, Capasso, Giovambattista, additional, Capote, F. Priego, additional, Cárdenas, Soledad, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pancorbo, Alegria, additional, Carnuccio, Rosa, additional, Carrera, María Pilar, additional, Carretero, Antonio Segura, additional, Casado, Francisco Javier, additional, Castillo, Julián, additional, Caturla, Nuria, additional, Cerretani, Lorenzo, additional, Chillemi, Rosa, additional, Chiou, Antonia, additional, Choi, Shin-Geon, additional, Christian, Mildred S., additional, Chondrogianni, Niki, additional, Churruca, Itziar, additional, Cirugeda, Miguel de la Guardia, additional, de Castro, Antonio, additional, De Caterina, Raffaele, additional, Cavaliere, Chiara, additional, Chinou, Ioanna, additional, Clodoveo, Maria Lisa, additional, Coimbra, Manuel A., additional, Conte, Lanfranco S., additional, Cosio, M. Stella, additional, Covas, Maria Isabel, additional, Coxam, Véronique, additional, Cunha, Sara C., additional, Curiel, Jose Antonio, additional, D’Angelo, Stefania, additional, Daniel, Hannelore, additional, Davicco, Marie-Jeanne, additional, De Bonis, Maria Luigia, additional, De Castro, M.D. Luque, additional, de la Higuera, Manuel, additional, de la Puerta, Cristina, additional, de las Rivas, Blanca, additional, de la Torre, Rafael, additional, Delcuratolo, Debora, additional, De Leonardis, Antonella, additional, De Lucia, Maria, additional, de Oliveira, Marcone Augusto Leal, additional, de Pablo, Manuel A., additional, De Roos, Baukje, additional, De Saja, Jose A., additional, De Stefano, Daniela, additional, Di Bella, Giuseppa, additional, Dichi, Isaias, additional, Diener, Robert M., additional, Dirsch, Verena M., additional, d’Ischia, Marco, additional, Driss, Fathi, additional, Dugo, Giacomo, additional, Dutta, Paresh C., additional, Ebizuk, Yutaka, additional, El-Benna, Jamel, additional, Esteban, Francisco J., additional, Estepa, Amparo, additional, da Silva, Joaquim C.G. Esteves, additional, Fabiani, Roberto, additional, Facino, Roberto Maffei, additional, Faria, M.A., additional, Faria, Miguel, additional, Fernandes, José O., additional, Fernandez-Gutierrez, Alberto, additional, Fernández-Montesinos, Rafael, additional, Fernández-Navarro, Mónica, additional, Fernández-Quintela, Alfredo, additional, Faria, Adriana Ferreira, additional, Fitó, Montserrat, additional, Fogher, Corrado, additional, Foglia, Patrizia, additional, Franconi, Flavia, additional, Fregapane, Giuseppe, additional, Fujimoto, Kazuma, additional, Fujise, Takehiro, additional, Furneri, Pio Maria, additional, Gallardo, Visitación, additional, Galletti, Patrizia, additional, Galvez, Julio, additional, Garcia, Aranzazu, additional, García, I.M., additional, García-Luna, Pedro P., additional, Garrido-Fernández, Antonio, additional, Garrigues, Salvador, additional, Geelen, Math J.H., additional, Geladopoulos, Taxiarchis, additional, Giamarellos-Bourboulis, Evangelos J., additional, Frenich, Antonia Garrido, additional, Galaris, Dimitrios, additional, Gilani, Anwarul Hassan, additional, Gill, Chris I.R., additional, Giovannini, Claudio, additional, Glatzle, Jörg, additional, Gnoni, Gabriele V., additional, Gomes, Tommaso, additional, Gómez-Rico, Aurora, additional, Gonos, Efstathios S., additional, Gonzalez, Carlos A., additional, Goya, Luis, additional, Grosovski, Maria, additional, Gutiérrez, Guillermo Rodriguez, additional, Hartmann, Marie-Andrée, additional, Hashim, Yumi Z., additional, Hu, Xiuli, additional, Ieri, Francesca, additional, Iliodromitis, Efstathios K., additional, Iwakiri, Ryuichi, additional, Juan, M. Emilia, additional, Kalogeropoulos, Nick, additional, Kalua, Curtis, additional, Khan, Arif-ullah, additional, Khymenets, Olha, additional, Kosti, Rena, additional, Kotsiou, Antonia, additional, Kremastinos, Dimitrios Th., additional, Lafont, Fernando, additional, Laganà, Aldo, additional, Landete, Jose Maria, additional, La Pera, Lara, additional, Lapucci, Chiara, additional, Lavermicocca, Paola, additional, Léger, Claude Louis, additional, Lehotay, Steven J., additional, Leone, Alessandro, additional, Liu, Jun, additional, Turco, Vincenzo Lo, additional, Lopez, Sergio, additional, de Cerain, Adela Lopez, additional, de Felipe, Felix Lopez, additional, López-Feria, Silvia, additional, de la Serrana, Herminia López-Garcia, additional, López-López, Antonio, additional, López-Martinez, Maria Carmen, additional, Lopez-Miranda, Jose, additional, La Torre, Giovanna Loredana, additional, Lucas, Ricardo, additional, Lupiáñez, José A., additional, Luque, Rafael, additional, Macciola, Vincenzo, additional, Madar, Zecharia, additional, Mafra, Isabel, additional, Magrì, Andrea D., additional, Magrì, Antonio L., additional, Maiuri, Maria Chiara, additional, Malaisse, Willy J., additional, Mañas, Mariano, additional, Mandarim-de-Lacerda, Carlos Alberto, additional, Manna, Caterina, additional, Mannina, Luisa, additional, Mannino, Saverio, additional, Marinas, Alberto, additional, Marinas, Jose M., additional, Marini, Federico, additional, Markaki, Panagiota, additional, Martín, M. Angeles, additional, Martínez, María Alba, additional, Martinez-Gonzalez, Miguel A., additional, Martínez-Gracia, María Victoria, additional, Martinez-Martos, José Manuel, additional, Martínez-Victoria, Emilio, additional, Masella, Roberta, additional, Massaro, Marika, additional, Mastovska, Katerina, additional, Mateos, Raquel, additional, Mazzoni, Michela, additional, Menéndez-Menéndez, Javier, additional, Medina, Eduardo, additional, Medina, Jose M., additional, Micol, Vicente, additional, Mikros, Emmanuel, additional, Mitjavila, Maria Teresa, additional, Montaño, Alfredo, additional, Morales, Juan Carlos, additional, Morcillo, Sonsoles, additional, Moreno, Juan José, additional, Moreno, Paola, additional, Moret, Sabrina, additional, Moros, Javier, additional, Morozzi, Guido, additional, Motilva, Maria-Jose, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Napoli, Daniela, additional, Napolitano, Alessandra, additional, Nassar, Faris, additional, Nasti, Raffaella, additional, Natali, Francesco, additional, Natalini, Paolo, additional, Nunes, Cláudia S., additional, Nychas, George, additional, Oliveira, M. 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2010
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