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15 results on '"Massari, Angelo"'

5. BACTERIAL EPIDEMIOLOGY AND ANTIMICROBIAL RESISTANCE IN THE SURGERY WARDS OF A LARGE TEACHING HOSPITAL IN SOUTHERN ITALY

Author

Esposito, Silvano, Gioia, Renato, De Simone, Giuseppe, Noviello, Silvana, Lombardi, Domenico, DI CRESCENZO, VINCENZO GIUSEPPE, Filippelli, Amelia, Rega, Maria Rosaria, Massari, Angelo, Elberti, Maria Giovanna, Grisi, Lucilla, Boccia, Giovanni, DE CARO, Francesco, and Leone, Sebastiano

Subjects
medicine.medical_specialty, medicine.drug_class, Antibiotics, medicine.disease_cause, Meropenem, Enterococcus faecalis, Antibiotic resistance, Staphylococcus epidermidis, medicine, biology, business.industry, Pseudomonas aeruginosa, lcsh:RC633-647.5, Hematology, lcsh:Diseases of the blood and blood-forming organs, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, Surgery, Acinetobacter baumannii, Infectious Diseases, Staphylococcus aureus, antibiotic resistance, bacterial infections, surgery wards, Original Article, business, medicine.drug
Abstract

Objectives: Surgical infections represent an increasingly important problem for the National Health System. In this study we retrospectively evaluated the bacterial epidemiology and antimicrobial susceptibility of the microorganisms concerned as well as the utilization of antibiotics in the General and Emergency Surgery wards of a large teaching hospital in southern Italy in the period 2011-2013.Methods: Data concerning bacterial isolates and antimicrobial susceptibility were retrieved from the Vitek II database. The pharmacy provided data about the consumption of antibiotics in the above reported wards. Chi-square or Fisher’s exact test were used to analyze categorical variables.Results: In all, 94 Gram-negative were isolated in 2011, 77 in 2012, and 125 in 2013, Escherichia coli, Acinetobacter baumannii and Pseudomonas aeruginosa always being the most frequently isolated microorganisms. In the same years, there were respectively 105, 93, and 165 Gram-positive isolated, Enterococcus faecalis, Staphylococcus epidermidis and Staphylococcus aureus being the most commonly found. No significant variation in the antibiotic susceptibility pattern was observed, either among Gram-negative or among Gram-positive pathogens; carbapenems (especially meropenem) consumption remained stable over time.Conclusions: Our results show no significant increase in antimicrobial resistance over the period in question, and a higher rate of both MRSA isolates and resistance to carbapenems in A. baumannii compared with other European data.

Published
2015

10. Abstract 16382: Length of Food Chain is Crucial in Determining the Impact of Mediterranean Diet on Metabolic Syndrome and Cardiovascular Risk

Author

Santulli, Gaetano, Pascale, Valeria, Finelli, Rosa, Visco, Valeria, Coscioni, Enrico, Giannotti, Rocco, Massari, Angelo, Ciccarelli, Michele, and Iaccarino, Guido

Abstract

Introduction:Substantial evidence has shown that Mediterranean diet can reduce the risk of metabolic syndrome (MS). However, the development of retail distribution has radically changed food supply worldwide. For instance, in the Mediterranean area, industrial retail favors shipments of groceries from regions that are intensive producers of mass food, generating the long supply chain (LSC) of food; on the other hand, short supply chains (SSCs) typically involve local self-producers promoting local markets. To our knowledge, the role of food retail and distribution in the determination of the risk of developing MS has not been studied hitherto.Hypothesis:We hypothesized that food chain length could affect the risk of developing metabolic alterations such as MS in a population accustomed to Mediterranean diet.Methods:We compared the SSC of food, in which aliments are mainly produced in loco, usually with traditional and low-technology methodologies, to the LSC of food. MS was defined using the latest ?Harmonized Criteria? to diagnose MS [CirculationVol.120 (16), Pg.1640]. The study was registered in the ClincalTrial.govdatabase (NCT03305276).Results:We recruited 407 subjects (average age: 56 years; 59% males), all adhering to Mediterranean diet, living in rural or urbanized areas of Southern Italy. The most important source of food in rural areas is represented by locally grown vegetables and meat of courtyard animals (SSC), whereas in metropolitan areas people mainly eat retail food (LSC). The actual dietary habits were confirmed through a validate questionnaire, designed to distinguish SSC and LSC viaa specific score. No significant differences were observed between SSC and LSC groups in terms of common demographic and metabolic parameters. Intriguingly, we found that being on Mediterranean diet with a SSC significantly (p=0.007) reduced the prevalence of MS compared with LSC, a result that was confirmed after correcting for confounding variables.Conclusions:Taken together, our findings show for the first time that the length of food supply chain is an independent predictor of the risk of MS in a population accustomed to Mediterranean diet, supporting the importance of local food environments in the determination of cardiovascular risk.

Published
2019
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11. We are What We Eat: Impact of Food from Short Supply Chain on Metabolic Syndrome

Author

Rocco Giannotti, Gaetano Santulli, Michele Ciccarelli, Enrico Coscioni, Rosa Finelli, Carmine Morisco, Valeria Visco, Guido Iaccarino, Angelo Massari, Maddalena Illario, Valeria Pascale, Santulli, Gaetano, Pascale, Valeria, Finelli, Rosa, Visco, Valeria, Giannotti, Rocco, Massari, Angelo, Morisco, Carmine, Ciccarelli, Michele, Illario, Maddalena, Iaccarino, Guido, and Coscioni, Enrico

Subjects
cardiovascular risk, Mediterranean diet, Supply chain, Population, Retail distribution, Distribution (economics), mediterranean diet, supply chain of food, metabolic syndrome, food retail, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, Food chain, 0302 clinical medicine, Food supply, Environmental health, Medicine, 030212 general & internal medicine, education, 2. Zero hunger, education.field_of_study, business.industry, General Medicine, medicine.disease, Metabolic syndrome, business
Abstract

Food supply in the Mediterranean area has been recently modified by big retail distribution; for instance, industrial retail has favored shipments of groceries from regions that are intensive producers of mass food, generating a long supply chain (LSC) of food that opposes short supply chains (SSCs) that promote local food markets. However, the actual functional role of food retail and distribution in the determination of the risk of developing metabolic syndrome (MetS) has not been studied hitherto. The main aim of this study was to test the effects of food chain length on the prevalence of MetS in a population accustomed to the Mediterranean diet. We conducted an observational study in Southern Italy on individuals adhering to the Mediterranean diet. We examined a total of 407 subjects (41% females) with an average age of 56 ± 14.5 years (as standard deviation) and found that being on the Mediterranean diet with a SSC significantly reduces the prevalence of MetS compared with the LSC (SSC: 19.65%, LSC: 31.46%; p: 0.007). Our data indicate for the first time that the length of food supply chain plays a key role in determining the risk of MetS in a population adhering to the Mediterranean diet.

Published
2019

12. Vitamin D, parathyroid hormone and cardiovascular risk: The good, the bad and the ugly

Author

Raffaele Izzo, Rosa Finelli, Guido Iaccarino, Enrico Coscioni, Ida Matula, Antonietta Valeria Pascale, Nicola Ragosa, Bruno Trimarco, Pietro Mazzeo, Michele Ciccarelli, Maddalena Illario, Angelo Massari, Valeria Visco, Davide Fabbricatore, Rocco Giannotti, Pascale, Antonietta V., Finelli, Rosa, Giannotti, Rocco, Visco, Valeria, Fabbricatore, Davide, Matula, Ida, Mazzeo, Pietro, Ragosa, Nicola, Massari, Angelo, Izzo, Raffaele, Coscioni, Enrico, Illario, Maddalena, Ciccarelli, Michele, Trimarco, Bruno, and Iaccarino, Guido

Subjects
Male, Percentile, 25-hydroxyvitamin D cholecalciferol, aging, blood pressure, cardiovascular events, cardiovascular risk, Cardiology and Cardiovascular Medicine, Parathyroid hormone, 030204 cardiovascular system & hematology, 0302 clinical medicine, Risk Factors, 030212 general & internal medicine, Young adult, Vitamin D, Research Articles, Aged, 80 and over, education.field_of_study, Framingham Risk Score, Age Factors, General Medicine, Middle Aged, cardiovascular event, Italy, Cardiovascular Diseases, Parathyroid Hormone, Female, Adult, medicine.medical_specialty, Adolescent, Population, Risk Assessment, 03 medical and health sciences, Young Adult, Sex Factors, Internal medicine, medicine, Vitamin D and neurology, Humans, education, Aged, Population mean, business.industry, Vitamin D Deficiency, Endocrinology, Blood pressure, Multivariate Analysis, Linear Models, business
Abstract

25-Hydroxyvitamin D insufficiency and increased cardiovascular risk (CVR) association is still debated. The vitamin D (VitD)-dependent parathyroid hormone (PTH) is considered as the possible actuator of VitD effects on CVR. To investigate the association of CVR, PTH and VitD, we carried out blood pressure measurements and blood samples and collected information on dietary habits, anamnestic, clinical and metabolic data of 451 participants in the Salerno area (Southern Italy) during the World Hypertension Day (17 May). CVR was calculated according to the Framingham CVR charts. The overall population mean age was 51.6 ± 0.7 years, and female sex was slightly prevalent (55%). VitD deficiency (

Published
2018

13. Mean reticolocyte hemoglobin content index plays a key role to identify children who are carriers of β-thalassemia.

Author

Vicinanza P, Vicinanza M, Cosimato V, Terracciano D, Cancellario S, Massari A, Danise P, Selleri C, and Serio B

Abstract

Reticulocyte (r) and red blood cell (RBC) indices provide reliable parameters for screening and monitoring iron deficiency anemia (IDA) patients and β-thalassemia trait (BTT) carriers. The aim of this study is to identify a simple method for use to distinguish β-thalassemia trait carriers from IDA and to evaluate the correlation between BTT genetic mutation and MCV values and new discrimination index for the detection of β-thalassemia trait (DI-BTT). We analyzed CHr, MCHCr, MCVr, RBC, mean cellular hemoglobin concentration (MCHC) and mean cellular volume (MCV) indices among a pediatric population of IDA patients (n=90), β-thalassemia trait carriers (n=72) and normal controls (NC) (n=131). Furthermore, to distinguish IDA patients from β-thalassemia trait carriers we evaluated clinical utility of new DI for the detection BTTcarriers, using the following polynomial: (RBC × MCHC × 50/MCV)/CHr. We found that CHr, MCVr and DI-BTT mean values were significantly different between β-thalassemia trait carriers and IDA patients. CHr, MCVr and DI-BTT plotting curves showed exclusive distribution in β-thalassemia trait carriers. Moreover, DI-BTT was very accurate in differentiating β-thalassemia trait carriers from IDA patients. All BTT patients showed a heterozygous mutation of the β-globin gene including CD39, IVS1.110, IVS1.6 and IVS2.745, IVS2.1 and IVS1.1. The highest MCV values were displayed by those carrying the IVS1.6 mutation., Conclusions: The simultaneous measurement and plotting of CHr and MCVr indices, as well as the DI-BTT allow to distinguish β-thalassemia carriers from IDA patients., Competing Interests: Conflict of interest The authors declare no conflict of interest.

Published
2018

14. Epidemiology and antibiotic resistance in a large Italian teaching hospital.

Author

Esposito S, Pascale R, Esposito I, Noviello S, Russo E, Simone GD, Vitolo M, Rega MR, and Massari A

Subjects
Acinetobacter Infections microbiology, Acinetobacter baumannii isolation & purification, Cross Infection epidemiology, Cross Infection microbiology, Hospitals, Teaching, Humans, Italy epidemiology, Klebsiella Infections microbiology, Klebsiella pneumoniae isolation & purification, Microbial Sensitivity Tests, Pseudomonas Infections microbiology, Pseudomonas aeruginosa isolation & purification, beta-Lactamases analysis, Acinetobacter Infections epidemiology, Acinetobacter baumannii drug effects, Anti-Bacterial Agents pharmacology, Drug Resistance, Multiple, Bacterial, Klebsiella Infections epidemiology, Klebsiella pneumoniae drug effects, Pseudomonas Infections epidemiology, Pseudomonas aeruginosa drug effects
Abstract

We focused our attention on susceptibility profile of Acinetobacter spp., Pseudomonas spp., and Klebsiella spp. isolated from biological specimens at the University Hospital of Salerno between June 2011 and October 2012. Acinetobacter, with a prevalence of Acinetobacter baumannii (97%) presented a high range of resistance to the antimicrobials considered, excluding colistin (COL). Klebsiella spp. isolates, with a prevalence of Klebsiella pneumoniae (90%), presented a variable pattern of resistance [from 9·8% for COL to 50% for levofloxacin (LEV)]. Extended-spectrum beta-lactamases production was detected in 15% of isolates. Most Pseudomonas isolates were P. aeruginosa with a high rate of resistance (95% to amoxicillin/clavulanate and trimethoprim/sulfamethoxazole, and <50% to the other antibiotics). Colistin remained the most effective drug tested. This study provided useful information of the local bacterial epidemiology hopefully permitting to establish a more effective empirical therapy, preventing the inappropriate use of antibacterial agents and possibly limiting the diffusion of antibacterial resistance.

Published
2015
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15. [Streptococcus gordonii extensive multiple subcutanoeus abscesses].

Author

Esposito S, Avallone L, Massari A, Lo Pardo D, Pezzuti G, Smaldone P, Anzalone S, and Ardimento P

Subjects
Abscess drug therapy, Abscess surgery, Aged, Anti-Bacterial Agents therapeutic use, Drainage, Female, Hip pathology, Humans, Scapula pathology, Streptococcal Infections drug therapy, Streptococcal Infections microbiology, Streptococcal Infections surgery, Thigh pathology, Treatment Outcome, Abscess diagnosis, Abscess microbiology, Streptococcal Infections diagnosis, Streptococcus gordonii isolation & purification
Abstract

We describe extensive multiple subcutaneous abscesses involving the peri-scapular region, the right posterior and lateral peri-trochanteric area and ipsilateral thigh occurring in a 66-years-old woman. Streptococcus gordonii was identified as the unique pathogen. Despite this microrganism is generally considered not pathogenic, it has been previously described as responsible for two cases of peritonitis and one case of endocarditis. The patient has been treated with immediate surgical incision and drainage and was cured after two months of antibiotic therapy, medications and hyperbaric oxygen therapy.

Published
2011

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