5,126 results on '"Maspero, A."'
Search Results
2. On higher order isolas of unstable Stokes waves
- Author
-
Berti, Massimiliano, Corsi, Livia, Maspero, Alberto, and Ventura, Paolo
- Subjects
Mathematics - Analysis of PDEs - Abstract
We overview the recent result [3, Theorem 1.1] about the high-frequency instability of Stokes waves subject to longitudinal perturbations. The spectral bands of unstable eigenvalues away from the origin form a sequence of {\it isolas} parameterized by an integer $ \mathtt{p} \geq 2 $ for any value of the depth $ \mathtt{h} > 0 $ such that an explicit analytic function $\beta_1^{(\mathtt{p})}(\mathtt{h}) $ is not zero. In [3] it is proved that the map $ \mathtt{h} \mapsto \beta_1^{(\mathtt{p})}(\mathtt{h}) $ is not identically zero for any $ \mathtt{p} \geq 2 $ by showing that $ \lim_{\mathtt{h} \to 0^+}\beta_1^{(\mathtt{p})}(\mathtt{h}) = - \infty $. In this manuscript we compute the asymptotic expansion of $\beta_1^{(\mathtt{p})}(\mathtt{h}) $ in the deep-water limit $ \mathtt{h} \to + \infty $ -- it vanishes exponentially fast to zero -- for $\mathtt{p}=2$, $3$, $4$., Comment: Supported by PRIN 2020 (2020XB3EFL001), PRIN 2022 (2022HSSYPN), ERC Stg 2021 HamDyWWa (101039762), ERC Cog 2023 GUnDHam (101124921). arXiv admin note: substantial text overlap with arXiv:2405.05854
- Published
- 2025
3. Deep learning-based auto-contouring of organs/structures-at-risk for pediatric upper abdominal radiotherapy
- Author
-
Ding, Mianyong, Maspero, Matteo, Littooij, Annemieke S, van Grotel, Martine, Fajardo, Raquel Davila, van Noesel, Max M, Heuvel-Eibrink, Marry M van den, and Janssens, Geert O
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Physics - Medical Physics - Abstract
Purposes: This study aimed to develop a computed tomography (CT)-based multi-organ segmentation model for delineating organs-at-risk (OARs) in pediatric upper abdominal tumors and evaluate its robustness across multiple datasets. Materials and methods: In-house postoperative CTs from pediatric patients with renal tumors and neuroblastoma (n=189) and a public dataset (n=189) with CTs covering thoracoabdominal regions were used. Seventeen OARs were delineated: nine by clinicians (Type 1) and eight using TotalSegmentator (Type 2). Auto-segmentation models were trained using in-house (ModelPMC-UMCU) and a combined dataset of public data (Model-Combined). Performance was assessed with Dice Similarity Coefficient (DSC), 95% Hausdorff Distance (HD95), and mean surface distance (MSD). Two clinicians rated clinical acceptability on a 5-point Likert scale across 15 patient contours. Model robustness was evaluated against sex, age, intravenous contrast, and tumor type. Results: Model-PMC-UMCU achieved mean DSC values above 0.95 for five of nine OARs, while spleen and heart ranged between 0.90 and 0.95. The stomach-bowel and pancreas exhibited DSC values below 0.90. Model-Combined demonstrated improved robustness across both datasets. Clinical evaluation revealed good usability, with both clinicians rating six of nine Type 1 OARs above four and six of eight Type 2 OARs above three. Significant performance 2 differences were only found across age groups in both datasets, specifically in the left lung and pancreas. The 0-2 age group showed the lowest performance. Conclusion: A multi-organ segmentation model was developed, showcasing enhanced robustness when trained on combined datasets. This model is suitable for various OARs and can be applied to multiple datasets in clinical settings., Comment: 23 pages, 5 figures, 1 table. Submitted to Radiotherapy and Oncology (2024-11-01)
- Published
- 2024
4. Growth of Sobolev norms for completely resonant quantum harmonic oscillators on $\mathbb{R}^2$
- Author
-
Langella, Beatrice, Maspero, Alberto, and Rotolo, Maria Teresa
- Subjects
Mathematics - Analysis of PDEs - Abstract
We consider time dependently perturbed quantum harmonic oscillators in $\mathbb{R}^2$: $$ {\rm i} \partial_t u=\frac12(-\partial_{x_1}^2-\partial_{x_2}^2 + x_1^2+x_2^2)u +V(t, x, D)u, \qquad \ x \in \mathbb{R}^2, $$ where $V(t, x, D)$ is a selfadjoint pseudodifferential operator of degree zero, $2\pi$ periodic in time. We identify sufficient conditions on the principal symbol of the potential $V(t, x, D)$ that ensure existence of solutions exhibiting unbounded growth in time of their positive Sobolev norms and we show that the class of symbols satisfying such conditions is generic in the Fr\'echet space of classical $2\pi$- time periodic symbols of order zero. To prove our result we apply the abstract Theorem of arXiv:2101.09055v1 : the main difficulty is to find a conjugate operator $A$ for the resonant average of $V(t,x, D)$. We construct explicitly the symbol of the conjugate operator $A$, called escape function, combining techniques from microlocal analysis, dynamical systems and contact topology.
- Published
- 2024
5. Three-dimensional nanoscale control of magnetism in crystalline Yttrium Iron Garnet
- Author
-
Levati, Valerio, Vitali, Matteo, Del Giacco, Andrea, Pellizzi, Nicola, Silvani, Raffaele, Mavilla, Luca Ciaccarini, Madami, Marco, Biancardi, Irene, Girardi, Davide, Panzeri, Matteo, Florio, Piero, Breitbach, David, Pirro, Philipp, Rovatti, Ludovica, Lecis, Nora, Maspero, Federico, Bertacco, Riccardo, Corrielli, Giacomo, Osellame, Roberto, Russo, Valeria, Bassi, Andrea Li, Tacchi, Silvia, Petti, Daniela, and Albisetti, Edoardo
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The exceptional magnetic, optical and phononic properties of Yttrium Iron Garnet (YIG) make it unique for spin-wave based and photonic applications. Yet, nanostructuring crystalline YIG and manipulating its magnetism in a non-destructive way is an outstanding challenge, and so far mostly limited to two-dimensional capabilities. Here, we show that irradiation of single-crystal YIG films with a focused UV laser drives a stable, giant enhancement of the perpendicular magnetic anisotropy, preserving the crystalline quality. This modulation is highly confined at the nanoscale in both the lateral and vertical directions, and its extension within the volume can be finely tuned with a continuous depth-control. By harnessing these three-dimensional anisotropy profiles, we demonstrate a large tuning of the spin-wave band structure, volume spatial localization, and non-reciprocity, realizing proof-of-principle 3D magnonic crystals. This straightforward, single-step, laser nanofabrication of three-dimensional magnetic systems based on crystalline YIG thin films opens the way to design novel functions in magnonic and magneto-optic devices., Comment: 17 pages, 5 figures
- Published
- 2024
6. One dimensional energy cascades in a fractional quasilinear NLS
- Author
-
Maspero, Alberto and Murgante, Federico
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Dynamical Systems - Abstract
We consider the problem of transfer of energy to high frequencies in a quasilinear Schr\"odinger equation with sublinear dispersion, on the one dimensional torus. We exhibit initial data undergoing finite but arbitrary large Sobolev norm explosion: their initial norm is arbitrary small in Sobolev spaces of high regularity, but at a later time becomes arbitrary large. We develop a novel mechanism producing instability, which is based on extracting, via paradifferential normal forms, an effective equation driving the dynamics whose leading term is a non-trivial transport operator with non-constant coefficients. We prove that such operator is responsible for energy cascades via a positive commutator estimate inspired by Mourre's commutator theory.
- Published
- 2024
7. Influence of buffer/protective layers on the structural and magnetic properties of SmCo films on Silicon
- Author
-
Maspero, F., Koplak, O. V., Plaza, A., Heinz, B., Kohl, F., Pirro, P., and Bertacco, R.
- Subjects
Condensed Matter - Materials Science - Abstract
Integration of Samarium Cobalt hard magnets on silicon requires buffer/protective layers that can enhance the magnetic properties of the magnet while preserving its structure and chemical composition after post-annealing treatments needed for the formation of the magnetically hard phase. In this work, a comparison of Samarium-Cobalt films for five different buffer/protective layers, namely Ti, W, TiW, Ta, Cr and two different annealing temperatures, 650{\deg}C and 750{\deg}C, is presented. Depending on materials and annealing temperatures, magnetic properties such as saturation and coercivity of the SmCo film can be finely tuned. We show that coercivity up to 3.65 T or saturation magnetization up to 0.95 T can be reached by proper choice of the relevant process parameters: deposition temperature, material for the buffer/protective layer and annealing temperature. Such value of coercivity is among the highest found in literature for thin films of SmCo.
- Published
- 2024
8. Deep learning-based brain segmentation model performance validation with clinical radiotherapy CT
- Author
-
Huisman, Selena, Maspero, Matteo, Philippens, Marielle, Verhoeff, Joost, and David, Szabolcs
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Manual segmentation of medical images is labor intensive and especially challenging for images with poor contrast or resolution. The presence of disease exacerbates this further, increasing the need for an automated solution. To this extent, SynthSeg is a robust deep learning model designed for automatic brain segmentation across various contrasts and resolutions. This study validates the SynthSeg robust brain segmentation model on computed tomography (CT), using a multi-center dataset. An open access dataset of 260 paired CT and magnetic resonance imaging (MRI) from radiotherapy patients treated in 5 centers was collected. Brain segmentations from CT and MRI were obtained with SynthSeg model, a component of the Freesurfer imaging suite. These segmentations were compared and evaluated using Dice scores and Hausdorff 95 distance (HD95), treating MRI-based segmentations as the ground truth. Brain regions that failed to meet performance criteria were excluded based on automated quality control (QC) scores. Dice scores indicate a median overlap of 0.76 (IQR: 0.65-0.83). The median HD95 is 2.95 mm (IQR: 1.73-5.39). QC score based thresholding improves median dice by 0.1 and median HD95 by 0.05mm. Morphological differences related to sex and age, as detected by MRI, were also replicated with CT, with an approximate 17% difference between the CT and MRI results for sex and 10% difference between the results for age. SynthSeg can be utilized for CT-based automatic brain segmentation, but only in applications where precision is not essential. CT performance is lower than MRI based on the integrated QC scores, but low-quality segmentations can be excluded with QC-based thresholding. Additionally, performing CT-based neuroanatomical studies is encouraged, as the results show correlations in sex- and age-based analyses similar to those found with MRI., Comment: 15 pages, 9 figures, 3 supplementary data csv's, 1 supplementary file with 1 figure
- Published
- 2024
9. Tuning magnonic devices with on-chip permanent micromagnets
- Author
-
Cocconcelli, Maria, Tacchi, Silvia, Erdélyi, Róbert, Maspero, Federico, Del Giacco, Andrea, Plaza, Alejandro, Koplak, Oksana, Cattoni, Andrea, Silvani, Raffaele, Madami, Marco, Papp, Ádam, Csaba, Gyorgy, Kohl, Felix, Heinz, Björn, Pirro, Philipp, and Bertacco, Riccardo
- Subjects
Physics - Applied Physics - Abstract
One of the most appealing features of magnonics is the easy tunability of spin-waves propagation via external magnetic fields. Usually this requires bulky and power-hungry electromagnets which are not compatible with device miniaturization. Here we propose a different approach, exploiting the stray field from permanent micromagnets integrated on the same chip of a magnonic wave-guide. In our monolithic device, we employ two SmCo square micromagnets (10x10 $\mu$m$^2$) flanking a CoFeB conduit at different distances from its axis, to produce a tunable transverse bias field between 7.5 and 3.0 mT in the conduit region between the magnets. Spin waves excited by an antenna just outside the region between the magnets enter a region with a variable higher (lower) effective field when an external bias field is applied parallel (antiparallel) to that from the micromagnets. Consequently, the attenuation length and phase shift of Damon-Eshbach spin waves can be tuned in a wide range by playing with the parallel-antiparallel configuration of the external bias and the distance between SmCo micromagnets and the CoFeB conduit. This work demonstrates the potential of permanent micro-magnets for the realization of low-power, integrated magnonic devices with tunable functionalities.
- Published
- 2024
10. Infinitely many isolas of modulational instability for Stokes waves
- Author
-
Berti, Massimiliano, Corsi, Livia, Maspero, Alberto, and Ventura, Paolo
- Subjects
Mathematics - Analysis of PDEs ,35B35 (Primary) 37K45, 76E30 (Secondary) - Abstract
We prove the long-standing conjecture regarding the existence of infinitely many high-frequency modulational instability ``isolas" for a Stokes wave in arbitrary depth $ \mathtt{h} > 0 $, subject to longitudinal perturbations. We completely describe the spectral bands with non-zero real part away from the origin of the $L^2(\mathbb{R})$-spectrum of the water waves system linearized at a Stokes waves of small amplitude $ \epsilon > 0 $. The unstable spectrum is the union of isolas of elliptical shape, parameterized by integers $ \mathtt{p}\geq 2 $, with semiaxis of size $ |\beta_1^{(\mathtt{p})} (\mathtt{h})| \epsilon^\mathtt{p}+ O(\epsilon^{\mathtt{p}+1} )$ where $\beta_1^{( \mathtt{p})} (\mathtt{h})$ is a nonzero analytic function of the depth $ \mathtt{h} $ that depends on the Taylor coefficients of the Stokes waves up to order $\mathtt{p}$., Comment: 58 pages, 10 figures, companion material at https://git-scm.sissa.it/amaspero/isolas/
- Published
- 2024
11. Full description of Benjamin-Feir instability for generalized Korteweg-de Vries equations
- Author
-
Maspero, Alberto and Radakovic, Antonio Milosh
- Subjects
Mathematics - Analysis of PDEs - Abstract
In this paper we consider a family of generalized Korteweg-de Vries equations and study the linear modulational instability of small amplitude traveling waves solutions. Under explicit non-degeneracy conditions on the dispersion relation, we completely describe the spectrum near the origin of the linearized operator at such solutions and prove that the unstable spectrum (when present) is composed by branches depicting always a closed figure ''8''. We apply our abstract theorem to several equations such as the Whitham, the gravity-capillary Whitham and the Kawahara equations, confirming that the unstable spectrum of the corresponding linearized operators exhibits a figure ''8'' instability, as it was observed before only numerically. Our method of proof uses a symplectic version of Kato's theory of similarity transformation to reduce the problem to determine the eigenvalues of a $3 \times 3$ complex Hamiltonian and reversible matrix. Then, via a block-diagonalization procedure, we conjugate such matrix into a block-diagonal one composed by a $2\times 2$ Hamiltonian and reversible matrix, describing the unstable spectrum, and a single purely imaginary element describing the stable eigenvalue.
- Published
- 2024
12. Generating Synthetic Computed Tomography for Radiotherapy: SynthRAD2023 Challenge Report
- Author
-
Huijben, Evi M. C., Terpstra, Maarten L., Galapon, Arthur Jr., Pai, Suraj, Thummerer, Adrian, Koopmans, Peter, Afonso, Manya, van Eijnatten, Maureen, Gurney-Champion, Oliver, Chen, Zeli, Zhang, Yiwen, Zheng, Kaiyi, Li, Chuanpu, Pang, Haowen, Ye, Chuyang, Wang, Runqi, Song, Tao, Fan, Fuxin, Qiu, Jingna, Huang, Yixing, Ha, Juhyung, Park, Jong Sung, Alain-Beaudoin, Alexandra, Bériault, Silvain, Yu, Pengxin, Guo, Hongbin, Huang, Zhanyao, Li, Gengwan, Zhang, Xueru, Fan, Yubo, Liu, Han, Xin, Bowen, Nicolson, Aaron, Zhong, Lujia, Deng, Zhiwei, Müller-Franzes, Gustav, Khader, Firas, Li, Xia, Zhang, Ye, Hémon, Cédric, Boussot, Valentin, Zhang, Zhihao, Wang, Long, Bai, Lu, Wang, Shaobin, Mus, Derk, Kooiman, Bram, Sargeant, Chelsea A. H., Henderson, Edward G. A., Kondo, Satoshi, Kasai, Satoshi, Karimzadeh, Reza, Ibragimov, Bulat, Helfer, Thomas, Dafflon, Jessica, Chen, Zijie, Wang, Enpei, Perko, Zoltan, and Maspero, Matteo
- Subjects
Physics - Medical Physics - Abstract
Radiation therapy plays a crucial role in cancer treatment, necessitating precise delivery of radiation to tumors while sparing healthy tissues over multiple days. Computed tomography (CT) is integral for treatment planning, offering electron density data crucial for accurate dose calculations. However, accurately representing patient anatomy is challenging, especially in adaptive radiotherapy, where CT is not acquired daily. Magnetic resonance imaging (MRI) provides superior soft-tissue contrast. Still, it lacks electron density information while cone beam CT (CBCT) lacks direct electron density calibration and is mainly used for patient positioning. Adopting MRI-only or CBCT-based adaptive radiotherapy eliminates the need for CT planning but presents challenges. Synthetic CT (sCT) generation techniques aim to address these challenges by using image synthesis to bridge the gap between MRI, CBCT, and CT. The SynthRAD2023 challenge was organized to compare synthetic CT generation methods using multi-center ground truth data from 1080 patients, divided into two tasks: 1) MRI-to-CT and 2) CBCT-to-CT. The evaluation included image similarity and dose-based metrics from proton and photon plans. The challenge attracted significant participation, with 617 registrations and 22/17 valid submissions for tasks 1/2. Top-performing teams achieved high structural similarity indices (>0.87/0.90) and gamma pass rates for photon (>98.1%/99.0%) and proton (>97.3%/97.0%) plans. However, no significant correlation was found between image similarity metrics and dose accuracy, emphasizing the need for dose evaluation when assessing the clinical applicability of sCT. SynthRAD2023 facilitated the investigation and benchmarking of sCT generation techniques, providing insights for developing MRI-only and CBCT-based adaptive radiotherapy., Comment: Preprint submitted to Medical Image Analysis
- Published
- 2024
13. Laser patterning of magnonic structure via local crystallization of Yittrium Iron Garnet
- Author
-
Del Giacco, A., Maspero, F., Levati, V., Vitali, M., Albisetti, E., Petti, D., Brambilla, L., Polewczyk, V., Vinai, G., Panaccione, G., Silvani, R., Madami, M., Tacchi, S., Dreyer, R., Lake, S. R., Woltersdorf, G., Schmidt, G., and Bertacco, Riccardo
- Subjects
Physics - Applied Physics - Abstract
The fabrication and integration of high-quality structures of Yttrium Iron Garnet (YIG) is critical for magnonics.Films with excellent properties are obtained only on single crystal Gadolinium Gallium Garnet (GGG) substrates using high-temperature processes. The subsequent realization of magnonic structures via lithography and etching is not straightforward as it requires a tight control of the edge roughness, to avoid magnon scattering, and planarization in case of multilayer devices. In this work we describe a different approach based on local laser annealing of amorphous YIG films, avoiding the need for subjecting the entire sample to high thermal budgets and for physical etching. Starting from amorphous and paramagnetic YIG films grown by pulsed laser deposition at room temperature on GGG, a 405 nm laser is used for patterning arbitrary shaped ferrimagnetic structures by local crystallization. In thick films (160 nm) the laser induced surface corrugation prevents the propagation of spin-wave modes in patterned conduits. For thinner films (80 nm) coherent propagation is observed in 1.2 micron wide conduits displaying an attenuation length of 5 micron which is compatible with a damping coefficient of about 5e-3. Possible routes to achieve damping coefficients compatible with state-of-the art epitaxial YIG films are discussed., Comment: 29 pages, 6 figures, This is the pre-peer reviewed version of the following article: "Patterning magnonic structures via laser induced crystallization of Yittrium Iron Garnet", by A. Del Giacco et al. https://doi.org/10.1002/adfm.202401129, which has been accepted for publication in Advanced Functional Materials
- Published
- 2024
- Full Text
- View/download PDF
14. Longtime dynamics for the Landau Hamiltonian with a time dependent magnetic field
- Author
-
Bambusi, Dario, Grébert, Benoit, Maspero, Alberto, Robert, Didier, and Villegas-Blas, Carlos
- Subjects
Mathematics - Analysis of PDEs ,Mathematical Physics - Abstract
We consider a modulated magnetic field, $B(t) = B_0 +\varepsilon f(\omega t)$, perpendicular to a fixed plane, where $B_0$ is constant, $\varepsilon>0$ and $f$ a periodic function on the torus ${\mathbb T}^n$. Our aim is to study classical and quantum dynamics for the corresponding Landau Hamiltonian. It turns out that the results depend strongly on the chosen gauge. For the Landau gauge the position observable is unbounded for "almost all" non resonant frequencies $\omega$. On the contrary, for the symmetric gauge we obtain that, for "almost all" non resonant frequencies $\omega$, the Landau Hamiltonian is reducible to a two dimensional harmonic oscillator and thus gives rise to bounded dynamics. The proofs use KAM algorithms for the classical dynamics. Quantum applications are given. In particular, the Floquet spectrum is absolutely continuous in the Landau gauge while it is discrete, of finite multiplicity, in symmetric gauge.
- Published
- 2024
15. A method to enhance the nonlinear magnetic plucking for vibration energy harvesters
- Author
-
Rosso, Michele, Cuccurullo, Simone, Perli, Filippo Pietro, Maspero, Federico, Corigliano, Alberto, and Ardito, Raffaele
- Published
- 2024
- Full Text
- View/download PDF
16. A snapshot on current approaches to lymphadenectomy in liver resection for intrahepatic cholangiocarcinoma: results from an international survey
- Author
-
Sposito, Carlo, Maspero, Marianna, Cucchetti, Alessandro, and Mazzaferro, Vincenzo
- Published
- 2024
- Full Text
- View/download PDF
17. Dentoskeletal effects of clear aligner vs twin block—a short-term study of functional appliances
- Author
-
Lombardo, Elisabetta Cretella, Lione, Roberta, Franchi, Lorenzo, Gaffuri, Francesca, Maspero, Cinzia, Cozza, Paola, and Pavoni, Chiara
- Published
- 2024
- Full Text
- View/download PDF
18. First isola of modulational instability of Stokes waves in deep water
- Author
-
Berti, Massimiliano, Maspero, Alberto, and Ventura, Paolo
- Subjects
Mathematics - Analysis of PDEs ,76B15 (Primary), 35B35, 76E99 (Secondary) - Abstract
We prove high-frequency modulational instability of small-amplitude Stokes waves in deep water under longitudinal perturbations, providing the first isola of unstable eigenvalues branching off from $\mathtt{i}\frac34$. Unlike the finite depth case this is a degenerate problem and the real part of the unstable eigenvalues has a much smaller size than in finite depth. By a symplectic version of Kato theory we reduce to search the eigenvalues of a $2\times 2$ Hamiltonian and reversible matrix which has eigenvalues with non-zero real part if and only if a certain analytic function is not identically zero. In deep water we prove that the Taylor coefficients up to order three of this function vanish, but not the fourth-order one., Comment: 35 pages, 4 figures, companion code https://git-scm.sissa.it/amaspero/first-isola-of-modulational-instability-of-stokes-waves-in-deep-water
- Published
- 2024
19. Parent’s acceptance of advanced behavior management techniques on children during dental treatment
- Author
-
Salerno, Claudia, Cirio, Silvia, Maspero, Cinzia, Roner, Margerita, D’Avola, Valeria, and Cagetti, Maria Grazia
- Published
- 2024
- Full Text
- View/download PDF
20. Hamiltonian Birkhoff Normal Form for Gravity-Capillary Water Waves with Constant Vorticity: Almost Global Existence: Hamiltonian Birkhoff Normal Form...
- Author
-
Berti, Massimiliano, Maspero, Alberto, and Murgante, Federico
- Published
- 2024
- Full Text
- View/download PDF
21. Ileal pouch-anal anastomosis and end ileostomy result in equivalent graft survival following liver transplantation for inflammatory bowel disease-primary sclerosing cholangitis
- Author
-
Schabl, L., Holubar, S. D., Maspero, M., Steele, S. R., and Hull, T.
- Published
- 2024
- Full Text
- View/download PDF
22. Automated radiosynthesis and preclinical evaluation of two new PSMA-617 derivatives radiolabelled via [18F]AlF2+ method
- Author
-
Iannone, Marco Nicola, Valtorta, Silvia, Stucchi, Stefano, Altomonte, Stefano, Turolla, Elia Anna, Vino, Elisa, Rainone, Paolo, Zecca, Valentina, Lo Dico, Alessia, Maspero, Marco, Figini, Mariangela, Bellone, Matteo, Ciceri, Samuele, Colombo, Diego, Chinello, Clizia, Pagani, Lisa, Moresco, Rosa Maria, Todde, Sergio, and Ferraboschi, Patrizia
- Published
- 2024
- Full Text
- View/download PDF
23. Three-dimensional spin-wave dynamics, localization and interference in a synthetic antiferromagnet
- Author
-
Girardi, Davide, Finizio, Simone, Donnelly, Claire, Rubini, Guglielmo, Mayr, Sina, Levati, Valerio, Cuccurullo, Simone, Maspero, Federico, Raabe, Jörg, Petti, Daniela, and Albisetti, Edoardo
- Published
- 2024
- Full Text
- View/download PDF
24. In-vitro dehydration kinetics coefficient of Kalifilcon A and other contact lens materials
- Author
-
Ponzini, Erika, Maspero, Francesco, Galli, Anna, and Tavazzi, Silvia
- Published
- 2024
- Full Text
- View/download PDF
25. Redo IPAA for long rectal cuff syndrome after ileoanal pouch for inflammatory bowel disease
- Author
-
Maspero, Marianna, Liska, David, Kessler, Hermann, Lipman, Jeremy, Steele, Scott R., Hull, Tracy, Qazi, Taha, Rieder, Florian, Cohen, Benjamin, and Holubar, Stefan D.
- Published
- 2024
- Full Text
- View/download PDF
26. Short-term effectiveness of the national German quitline for smoking cessation: results of a randomized controlled trial
- Author
-
Maspero, Simona, Delle, Simone, Kraus, Ludwig, Pogarell, Oliver, Hoch, Eva, Bachner, Joachim, and Lochbühler, Kirsten
- Published
- 2024
- Full Text
- View/download PDF
27. The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease
- Author
-
Otero-Piñerio, Ana M., Aykun, N., Maspero, M., Holubar, Stefan, Hull, Tracy, Lipman, Jeremy, Steele, Scott R., and Lightner, Amy L.
- Published
- 2024
- Full Text
- View/download PDF
28. Stokes waves at the critical depth are modulational unstable
- Author
-
Berti, Massimiliano, Maspero, Alberto, and Ventura, Paolo
- Subjects
Mathematics - Analysis of PDEs ,76B15 (Primary) 76E15 (Secondary) - Abstract
This paper fully answers a long standing open question concerning the stability/instability of pure gravity periodic traveling water waves -- called Stokes waves -- at the critical Whitham-Benjamin depth $ \mathtt{h}_{\scriptscriptstyle WB} = 1.363... $ and nearby values. We prove that Stokes waves of small amplitude $ \mathcal{O}( \epsilon ) $ are, at the critical depth $ \mathtt{h}_{\scriptscriptstyle WB} $, linearly unstable under long wave perturbations. This is also true for slightly smaller values of the depth $ \mathtt{h} > \mathtt{h}_{\scriptscriptstyle WB} - c \epsilon^2 $, $ c > 0 $, depending on the amplitude of the wave. This problem was not rigorously solved in previous literature because the expansions degenerate at the critical depth. In order to resolve this degenerate case, and describe in a mathematically exhaustive way how the eigenvalues change their stable-to-unstable nature along this shallow-to-deep water transient, we Taylor expand the computations of arXiv:2204.00809v2 at a higher degree of accuracy, derived by the fourth order expansion of the Stokes waves. We prove that also in this transient regime a pair of unstable eigenvalues depict a closed figure "8", of smaller size than for $ \mathtt{h} > \mathtt{h}_{\scriptscriptstyle WB} $, as the Floquet exponent varies., Comment: 52 pages, 6 figures, companion Mathematica code available at https://git-scm.sissa.it/amaspero/benjamin-feir-instability. arXiv admin note: text overlap with arXiv:2204.00809
- Published
- 2023
29. Phononic graded meta-MEMS for elastic wave amplification and filtering
- Author
-
Maspero, Federico, De Ponti, Jacopo Maria, Iorio, Luca, Esposito, Annachiara, Bertacco, Riccardo, di Matteo, Andrea, Corigliano, Alberto, and Ardito, Raffaele
- Subjects
Physics - Applied Physics - Abstract
Inspired by recent graded metamaterials designs, we create phononic arrays of micro-resonators for frequency signal amplification and wave filtering. Leveraging suspended waveguides on a thick silicon substrate, we hybridize surface Rayleigh and Lamb flexural waves to effectively achieve phononic signal control along predefined channels. The guided waves are then spatially controlled using a suitable grading of the micro-resonators, which provide high signal-to-noise ratio and simultaneously create phononic delay-lines. The proposed device can be used for sensing, wave filtering or energy harvesting.
- Published
- 2023
30. Generalizable synthetic MRI with physics-informed convolutional networks
- Author
-
Jacobs, Luuk, Mandija, Stefano, Liu, Hongyan, Berg, Cornelis A. T. van den, Sbrizzi, Alessandro, and Maspero, Matteo
- Subjects
Physics - Medical Physics ,Computer Science - Computer Vision and Pattern Recognition - Abstract
In this study, we develop a physics-informed deep learning-based method to synthesize multiple brain magnetic resonance imaging (MRI) contrasts from a single five-minute acquisition and investigate its ability to generalize to arbitrary contrasts to accelerate neuroimaging protocols. A dataset of fifty-five subjects acquired with a standard MRI protocol and a five-minute transient-state sequence was used to develop a physics-informed deep learning-based method. The model, based on a generative adversarial network, maps data acquired from the five-minute scan to "effective" quantitative parameter maps, here named q*-maps, by using its generated PD, T1, and T2 values in a signal model to synthesize four standard contrasts (proton density-weighted, T1-weighted, T2-weighted, and T2-weighted fluid-attenuated inversion recovery), from which losses are computed. The q*-maps are compared to literature values and the synthetic contrasts are compared to an end-to-end deep learning-based method proposed by literature. The generalizability of the proposed method is investigated for five volunteers by synthesizing three non-standard contrasts unseen during training and comparing these to respective ground truth acquisitions via contrast-to-noise ratio and quantitative assessment. The physics-informed method was able to match the high-quality synthMRI of the end-to-end method for the four standard contrasts, with mean \pm standard deviation structural similarity metrics above 0.75 \pm 0.08 and peak signal-to-noise ratios above 22.4 \pm 1.9 and 22.6 \pm 2.1. Additionally, the physics-informed method provided retrospective contrast adjustment, with visually similar signal contrast and comparable contrast-to-noise ratios to the ground truth acquisitions for three sequences unused for model training, demonstrating its generalizability and potential application to accelerate neuroimaging protocols., Comment: 23 pages, 7 figures, 1 table. Presented at ISMRM 2022. Will be submitted to NMR in biomedicine
- Published
- 2023
- Full Text
- View/download PDF
31. Ecumenical Relational Ontology in Dialogue with Thomism
- Author
-
Maspero, Giulio
- Published
- 2024
- Full Text
- View/download PDF
32. SynthRAD2023 Grand Challenge dataset: generating synthetic CT for radiotherapy
- Author
-
Thummerer, Adrian, van der Bijl, Erik, Galapon, Arthur Jr, Verhoeff, Joost JC, Langendijk, Johannes A, Both, Stefan, Cornelis, Berg, AT van den, and Maspero, Matteo
- Subjects
Physics - Medical Physics ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Purpose: Medical imaging has become increasingly important in diagnosing and treating oncological patients, particularly in radiotherapy. Recent advances in synthetic computed tomography (sCT) generation have increased interest in public challenges to provide data and evaluation metrics for comparing different approaches openly. This paper describes a dataset of brain and pelvis computed tomography (CT) images with rigidly registered CBCT and MRI images to facilitate the development and evaluation of sCT generation for radiotherapy planning. Acquisition and validation methods: The dataset consists of CT, CBCT, and MRI of 540 brains and 540 pelvic radiotherapy patients from three Dutch university medical centers. Subjects' ages ranged from 3 to 93 years, with a mean age of 60. Various scanner models and acquisition settings were used across patients from the three data-providing centers. Details are available in CSV files provided with the datasets. Data format and usage notes: The data is available on Zenodo (https://doi.org/10.5281/zenodo.7260705) under the SynthRAD2023 collection. The images for each subject are available in nifti format. Potential applications: This dataset will enable the evaluation and development of image synthesis algorithms for radiotherapy purposes on a realistic multi-center dataset with varying acquisition protocols. Synthetic CT generation has numerous applications in radiation therapy, including diagnosis, treatment planning, treatment monitoring, and surgical planning., Comment: 15 pages, 4 figures, 9 tables, pre-print submitted to Medical Physics - dataset. The training dataset is available on Zenodo at https://doi.org/10.5281/zenodo.7260705 from April, 1st 2023
- Published
- 2023
- Full Text
- View/download PDF
33. Exploring contrast generalisation in deep learning-based brain MRI-to-CT synthesis
- Author
-
Nijskens, Lotte, Cornelis, Berg, AT van den, Verhoeff, Joost JC, and Maspero, Matteo
- Subjects
Physics - Medical Physics ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Background: Synthetic computed tomography (sCT) has been proposed and increasingly clinically adopted to enable magnetic resonance imaging (MRI)-based radiotherapy. Deep learning (DL) has recently demonstrated the ability to generate accurate sCT from fixed MRI acquisitions. However, MRI protocols may change over time or differ between centres resulting in low-quality sCT due to poor model generalisation. Purpose: investigating domain randomisation (DR) to increase the generalisation of a DL model for brain sCT generation. Methods: CT and corresponding T1-weighted MRI with/without contrast, T2-weighted, and FLAIR MRI from 95 patients undergoing RT were collected, considering FLAIR the unseen sequence where to investigate generalisation. A ``Baseline'' generative adversarial network was trained with/without the FLAIR sequence to test how a model performs without DR. Image similarity and accuracy of sCT-based dose plans were assessed against CT to select the best-performing DR approach against the Baseline. Results: The Baseline model had the poorest performance on FLAIR, with mean absolute error (MAE)=106$\pm$20.7 HU (mean$\pm\sigma$). Performance on FLAIR significantly improved for the DR model with MAE=99.0$\pm$14.9 HU, but still inferior to the performance of the Baseline+FLAIR model (MAE=72.6$\pm$10.1 HU). Similarly, an improvement in $\gamma$-pass rate was obtained for DR vs Baseline. Conclusions: DR improved image similarity and dose accuracy on the unseen sequence compared to training only on acquired MRI. DR makes the model more robust, reducing the need for re-training when applying a model on sequences unseen and unavailable for retraining., Comment: Preprint submitted to Physica Medica on 2023-02-16 for review. Also published in Zenodo at https://doi.org/10.5281/zenodo.7742642
- Published
- 2023
- Full Text
- View/download PDF
34. Validation of SynthSeg segmentation performance on CT using paired MRI from radiotherapy patients
- Author
-
Selena Huisman, Matteo Maspero, Marielle Philippens, Joost Verhoeff, and Szabolcs David
- Subjects
Deep learning ,Validation ,Clinical brain MRI ,Clinical brain CT ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Introduction:: Manual segmentation of medical images is labor intensive and especially challenging for images with poor contrast or resolution. The presence of disease exacerbates this further, increasing the need for an automated solution. To this extent, SynthSeg is a robust deep learning model designed for automatic brain segmentation across various contrasts and resolutions. This study validates the SynthSeg robust brain segmentation model on computed tomography (CT), using a multi-center dataset. Methods:: An open access dataset of 260 paired CT and magnetic resonance imaging (MRI) from radiotherapy patients treated in 5 centers was collected. Brain segmentations from CT and MRI were obtained with SynthSeg model, a component of the Freesurfer imaging suite. These segmentations were compared and evaluated using Dice scores and Hausdorff 95 distance (HD95), treating MRI-based segmentations as the ground truth. Brain regions that failed to meet performance criteria were excluded based on automated quality control (QC) scores. Results:: Dice scores indicate a median overlap of 0.76 (IQR: 0.65-0.83). The mean volume difference is 7.79% (CI: 6.41%–9.18%), with CT segmentations typically smaller than MRI-based. The median HD95 is 2.95 mm (IQR: 1.73-5.39). QC score based thresholding improves median dice by 0.1 and median HD95 by 0.05 mm. Morphological differences related to sex and age, as detected by MRI, were also replicated with CT, with an approximate 17% difference between the CT and MRI results for sex and 10% difference between the results for age. Conclusion:: SynthSeg can be utilized for CT-based automatic brain segmentation, but only in applications where precision is not essential. CT performance is lower than MRI based on the integrated QC scores, but low-quality segmentations can be excluded with QC-based thresholding. Additionally, performing CT-based neuroanatomical studies is encouraged, as the results show correlations in sex- and age-based analyses similar to those found with MRI.
- Published
- 2024
- Full Text
- View/download PDF
35. Long-term safety of mepolizumab for up to ∼10 years in patients with severe asthma: open-label extension study
- Author
-
Ian Pavord, Robert Chan, Nicola Brown, Peter Howarth, Martyn Gilson, Robert G. Price, and Jorge Maspero
- Subjects
Long-term access program ,mepolizumab ,open-label extension ,safety ,severe asthma with an eosinophilic phenotype ,Medicine - Abstract
Objectives Long-term safety monitoring of mepolizumab is necessary to support real-world use for the treatment of severe asthma. This Long-Term Access Program assessed the safety and benefit:risk of mepolizumab in pediatric, adolescent, and adult patients with severe asthma.Materials and methods This was a multicenter, Phase IIIb safety, open-label extension study of multiple prior studies assessing mepolizumab in addition to standard of care (Aug 2015 − Aug 2022). Adults/adolescents (≥12 years of age) received mepolizumab 100 mg subcutaneously (SC) every 4 weeks until mepolizumab was commercialized. Pediatric patients (6–11 years of age) received mepolizumab 40 mg or 100 mg SC (bodyweight
- Published
- 2024
- Full Text
- View/download PDF
36. Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
- Author
-
Roberta Pascolutti, Veronica Algisi, Alexia Conte, Andrea Raimondi, Mithun Pasham, Srigokul Upadhyayula, Raphael Gaudin, Tanja Maritzen, Elisa Barbieri, Giusi Caldieri, Chiara Tordonato, Stefano Confalonieri, Stefano Freddi, Maria Grazia Malabarba, Elena Maspero, Simona Polo, Carlo Tacchetti, Volker Haucke, Tom Kirchhausen, Pier Paolo Di Fiore, and Sara Sigismund
- Subjects
Biology (General) ,QH301-705.5 - Published
- 2024
- Full Text
- View/download PDF
37. Corrigendum to 'Epidemiology of adult patients with atopic dermatitis in AWARE 1: A second international survey' [World Allergy Organ J 16 (3) (2023) 100724]
- Author
-
Jorge Maspero, Norma De Paula Motta Rubini, Jianzhong Zhang, Gloria Sanclemente, Julio Roberto Amador, Marhira Hamdy El Sayed, Alsan Chan Wai Ming, Roni P. Dodiuk-Gad, Issam Hamadah, Suganthi Thevarajah, Catalina Rincón-Perez, Elena Fedenko, Yik Weng Yew, Mark B.Y. Tang, Chia-Yu Chu, Kanokvalai Kulthanan, Ozlem Su Kucuk, Anwar Al-Hammadi, Lysel Brignoli, Angelina Tsankova, Sarah El-Samad, Jose Eduardo Neves, and Laurent Eckert
- Subjects
Immunologic diseases. Allergy ,RC581-607 - Published
- 2024
- Full Text
- View/download PDF
38. Hamiltonian Birkhoff normal form for gravity-capillary water waves with constant vorticity: almost global existence
- Author
-
Berti, Massimiliano, Maspero, Alberto, and Murgante, Federico
- Subjects
Mathematics - Analysis of PDEs - Abstract
We prove an almost global in time existence result of small amplitude space periodic solutions of the 1D gravity-capillary water waves equations with constant vorticity. The result holds for any value of gravity, vorticity and depth and any surface tension belonging to a full measure set. The proof demands a Hamiltonian paradifferential Birkhoff normal form reduction for quasi-linear PDEs in presence of resonant wave interactions: the normal form may be not integrable but it preserves the Sobolev norms thanks to its Hamiltonian nature. A major difficulty is that usual paradifferential calculus used to prove local well posedness (as the celebrated Alinhac good unknown) does not preserve the Hamiltonian structure. A major novelty of this paper is to develop an algorithmic perturbative procedure \`a la Darboux to correct usual paradifferential transformations to symplectic maps, up to an arbitrary degree of homogeneity. The symplectic correctors turn out to be smoothing perturbations of the identity, and therefore only slightly modify the paradifferential structure of the equations. The Darboux procedure which recovers the nonlinear Hamiltonian structure is written in an abstract functional setting, in order to be applicable also in other contexts., Comment: 132 pages
- Published
- 2022
39. Roton-like dispersion via polarisation change for elastic wave energy control in graded delay-lines
- Author
-
Iorio, Luca, De Ponti, Jacopo Maria, Maspero, Federico, and Ardito, Raffaele
- Subjects
Physics - Classical Physics - Abstract
While roton dispersion relations had been restricted to correlated quantum systems at low temperature, recent works show the possibility of obtaining this unusual dispersion in acoustic and elastic metamaterials. Such phenomenon has been demonstrated in periodic structures by means of beyond-nearest-neighbor interactions, following the formulation firstly developed by Brillouin in the $'50s$. In this paper, we demonstrate both numerically and experimentally that beyond-nearest-neighbor connections are not a necessary condition to obtain this unusual dispersion relation in elasticity. Leveraging the intrinsic complexity of elastic systems supporting different types of waves, we demonstrate that mode locking can be applied to obtain roton dispersion, without the need of elastic or magnetic interactions between non nearest neighbors. Moreover, the combination of roton dispersion and rainbow physics enables spatial separation of the energy fluxes with positive and negative group velocity.
- Published
- 2022
40. Accelerated respiratory-resolved 4D-MRI with separable spatio-temporal neural networks
- Author
-
Terpstra, Maarten, Maspero, Matteo, Verhoeff, Joost, and Berg, Cornelis van den
- Subjects
Physics - Medical Physics ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Background: Respiratory-resolved four-dimensional magnetic resonance imaging (4D-MRI) provides essential motion information for accurate radiation treatments of mobile tumors. However, obtaining high-quality 4D-MRI suffers from long acquisition and reconstruction times. Purpose: To develop a deep learning architecture to quickly acquire and reconstruct high-quality 4D-MRI, enabling accurate motion quantification for MRI-guided radiotherapy. Methods: A small convolutional neural network called MODEST is proposed to reconstruct 4D-MRI by performing a spatial and temporal decomposition, omitting the need for 4D convolutions to use all the spatio-temporal information present in 4D-MRI. This network is trained on undersampled 4D-MRI after respiratory binning to reconstruct high-quality 4D-MRI obtained by compressed sensing reconstruction. The network is trained, validated, and tested on 4D-MRI of 28 lung cancer patients acquired with a T1-weighted golden-angle radial stack-of-stars sequence. The 4D-MRI of 18, 5, and 5 patients were used for training, validation, and testing. Network performances are evaluated on image quality measured by the structural similarity index (SSIM) and motion consistency by comparing the position of the lung-liver interface on undersampled 4D-MRI before and after respiratory binning. The network is compared to conventional architectures such as a U-Net, which has 30 times more trainable parameters. Results: MODEST can reconstruct high-quality 4D-MRI with higher image quality than a U-Net, despite a thirty-fold reduction in trainable parameters. High-quality 4D-MRI can be obtained using MODEST in approximately 2.5 minutes, including acquisition, processing, and reconstruction. Conclusion: High-quality accelerated 4D-MRI can be obtained using MODEST, which is particularly interesting for MRI-guided radiotherapy., Comment: Code available at https://gitlab.com/computational-imaging-lab/modest
- Published
- 2022
- Full Text
- View/download PDF
41. Expanding Selection Criteria in Deceased Donor Liver Transplantation for Hepatocellular Carcinoma: Long-term Follow-up of a National Registry and 2 Transplant Centers
- Author
-
Wehrle, Chase J., Kusakabe, Jiro, Akabane, Miho, Maspero, Marianna, Zervos, Bobby, Modaresi Esfeh, Jamak, Whitsett Linganna, Maureen, Imaoka, Yuki, Khalil, Mazhar, Pita, Alejandro, Kim, Jaekeun, Diago-Uso, Teresa, Fujiki, Masato, Eghtesad, Bijan, Quintini, Cristiano, Kwon, Choon David, Pinna, Antonio, Aucejo, Federico, Miller, Charles, Mazzaferro, Vincenzo, Schlegel, Andrea, Sasaki, Kazunari, and Hashimoto, Koji
- Published
- 2024
- Full Text
- View/download PDF
42. Reducibility and nonlinear stability for a quasi-periodically forced NLS
- Author
-
Haus, Emanuele, Langella, Beatrice, Maspero, Alberto, and Procesi, Michela
- Subjects
Mathematics - Analysis of PDEs - Abstract
Motivated by the problem of long time stability vs. instability of KAM tori of the Nonlinear cubic Schr\"odinger equation (NLS) on the two dimensional torus $\mathbb T^2:= (\mathbb R/2\pi \mathbb Z)^2$, we consider a quasi-periodically forced NLS equation on $\mathbb T^2$ arising from the linearization of the NLS at a KAM torus. We prove a reducibility result as well as long time stability of the origin. The main novelty is to obtain the precise asymptotic expansion of the frequencies which allows us to impose Melnikov conditions at arbitrary order.
- Published
- 2022
43. Assessing the Robustness of Image Registration Models Under Domain Shifts with Learnable Input Images.
- Author
-
Iris Kolenbrander, Vidya Prasad, Leanne Zikken, Maureen A. J. M. van Eijnatten, Matteo Maspero, and Josien P. W. Pluim
- Published
- 2024
- Full Text
- View/download PDF
44. Social Doctrine of the Church and Relational Ontology: The Trinitarian Roots of Subsidiarity
- Author
-
Maspero, Giulio, Vigorelli, Ilaria, Schlag, Martin, editor, and Koller, Boglárka, editor
- Published
- 2024
- Full Text
- View/download PDF
45. Cure after surgery for hepato-pancreato-biliary cancers: A systematic review
- Author
-
Maspero, Marianna, Sposito, Carlo, Mazzaferro, Vincenzo, Ercolani, Giorgio, and Cucchetti, Alessandro
- Published
- 2025
- Full Text
- View/download PDF
46. Automatic segmentation for magnetic resonance imaging guided individual elective lymph node irradiation in head and neck cancer patients
- Author
-
Floris C.J. Reinders, Mark H.F. Savenije, Mischa de Ridder, Matteo Maspero, Patricia A.H. Doornaert, Chris H.J. Terhaard, Cornelis P.J. Raaijmakers, Kaveh Zakeri, Nancy Y. Lee, Eric Aliotta, Aneesh Rangnekar, Harini Veeraraghavan, and Marielle E.P. Philippens
- Subjects
Deep learning ,Artificial intelligence ,Lymph nodes ,Magnetic resonance imaging ,Radiotherapy ,Squamous cell carcinoma of head and neck ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and purpose: In head and neck squamous cell carcinoma (HNSCC) patients, the radiation dose to nearby organs at risk can be reduced by restricting elective neck irradiation from lymph node levels to individual lymph nodes. However, manual delineation of every individual lymph node is time-consuming and error prone. Therefore, automatic magnetic resonance imaging (MRI) segmentation of individual lymph nodes was developed and tested using a convolutional neural network (CNN). Materials and methods: In 50 HNSCC patients (UMC-Utrecht), individual lymph nodes located in lymph node levels Ib-II-III-IV-V were manually segmented on MRI by consensus of two experts, obtaining ground truth segmentations. A 3D CNN (nnU-Net) was trained on 40 patients and tested on 10. Evaluation metrics were Dice Similarity Coefficient (DSC), recall, precision, and F1-score. The segmentations of the CNN was compared to segmentations of two observers. Transfer learning was used with 20 additional patients to re-train and test the CNN in another medical center. Results: nnU-Net produced automatic segmentations of elective lymph nodes with median DSC: 0.72, recall: 0.76, precision: 0.78, and F1-score: 0.78. The CNN had higher recall compared to both observers (p = 0.002). No difference in evaluation scores of the networks in both medical centers was found after re-training with 5 or 10 patients. Conclusion: nnU-Net was able to automatically segment individual lymph nodes on MRI. The detection rate of lymph nodes using nnU-Net was higher than manual segmentations. Re-training nnU-Net was required to successfully transfer the network to the other medical center.
- Published
- 2024
- Full Text
- View/download PDF
47. Liver Transplantation for Intrahepatic Cholangiocarcinoma After Chemotherapy and Radioembolization: An Intention-To-Treat Study
- Author
-
Marianna Maspero, Carlo Sposito, Marco A. Bongini, Tommaso Cascella, Maria Flores, Marco Maccauro, Carlo Chiesa, Monica Niger, Filippo Pietrantonio, Giuseppe Leoncini, Valentina Bellia, Sherrie Bhoori, and Vincenzo Mazzaferro
- Subjects
biliary tract cancers ,downstaging ,gemcitabine-cisplatin ,Yttrium-90 ,tare ,Specialties of internal medicine ,RC581-951 - Abstract
Liver transplantation (LT) is a potentially curative experimental treatment for unresectable intrahepatic cholangiocarcinoma (iCC). Pre-transplant downstaging may help defining tumor aggressiveness and drive patient selection. We report the preliminary results of LT for liver-limited unresectable iCC after sequential downstaging with systemic chemotherapy and radioembolization (SYS-TARE). In case of sustained disease stability after SYS-TARE, patients underwent surgical nodal sampling and, if negative, were listed for LT. In this study, 13 patients with unresectable iCC underwent downstaging with SYS-TARE. The median age was 70 years and 77% were female. All had single bulky lesions at diagnosis. After SYS-TARE, 9 (69%) dropped out: 3 due to progressive disease after TARE with no response to second-line, 4 due to extrahepatic disease development and 2 due to positive nodal disease at pre-listing abdominal exploration. The median OS after dropout was 11.5 months. Four (31%) were successfully listed and transplanted. At pathology, viable tumor ranged from 30% to less than 5%. All four patients are alive and disease-free at 73, 40, 12, and 8 months from LT. LT for unresectable iCC after downstaging with SYS-TARE appears to select suitable patients for LT, achieving optimal oncological outcomes in case of response to therapy and no lymphnodal spread.
- Published
- 2024
- Full Text
- View/download PDF
48. Perceptions of the impact of individual allergic rhinitis symptoms: A survey of ARIA clinical experts
- Author
-
Asllani, Julijana, Douagui, Habib, Asayag, Estrella, Elizabeth, Castro Maria, Crisci, Carlos D., Gomez, René Maximiliano, Ivancevich, Juan Carlos, Jares, Edgardo, Máspero, Jorge Fernando, Moreno, Pablo, Neffen, Hugo Eduardo, Zernotti, Mario Emilio, Bosnic-Anticevich, Sinthia, Chahhoud Carson, Kristin, Cvetkovski, Biljana, Davies, Janet M., Kritikos, Vicky, O'Hehir, Robyn, Oliver, Brian, Tan, House Rachel, Tattersall, Jessica, Zubrinich, Celia, Aberer, Werner, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Doyen, Virginie, Ebo, Didier, Louis, Renaud, Rombaux, Philippe, Scheire, Sophie, Bennoor, Kazi, Barreto, Bruno A., Camargos, Paulo, Chong-Neto, Herberto Jose, Cruz, Alvaro A., da Silva, Jane, Marta, Guidacci, Rizzo, José Angelo, Rosario Filho, Nelson, Faradiba, Sarquis Serpa, Solé, Dirceu, Urrutia-Pereira, Marilyn, Christoff, George, Mariana, Mandazhieva-Pepelanova, Cvetanka, Odjakova, Popov, Todor A., Vicheva, Dilyana, Teixeira Maria, do Ceu, Bouchard, Jacques, Brozek, Jan, Chu, Derek K., Denburg, Judah, Eiwegger, Thomas, Keith, Paul K., To, Teresa, Waserman, Susan, Abusada, Nancy, Alvarez Cuesta, Emilio, Calvo-Gil, Mario A., Guzmán, Maria Antonieta, Pérez Gomez, Tamara, Wong Gary, Wing Kin, Zhang, Luo, Caraballo, Luis, Cepeda Sarabia, Alfonso, Nyembue, Dieudonné, Soto-Martinez, Manuel, Miculinic, Neven, Plavec, Davor, Pitsios, Constantinos, Yiallouros, Panayiotis, Panzner, Petr, Sova, Milan, Vachova, Martina, Bindslev-Jensen, Carsten, Dahl, Ronald, Malling, Hans-Jorgen, Münter, Lars, Poulsen, Lars K., Charlotte, Suppli Ulrik, Tannert, Line Kring, Mahboub, Bassam, Salameh, Laila, Cherrez-Ojeda, Ivan, Robles, de Guevara Karla, El-Owaidy, Rasha Hassan, El-Sayed, Zeinab A., El-Sayed, Shereen Saad, Hossny, Elham, Mostafa, Badr Eldin, Julge, Kaja, Billo, Nils Eric, Eklund, Patrik, Erhola, Marina, Haahtela, Tari, Karjalainen, Jussi, Makela, Mika, Toppila-Salmi, Sanna, Valovirta, Erkka, Vasankari, Tuula, Annesi-Maesano, Isabella, Bossé, Isabelle, Bourgoin-Heck, Melisande, Charpin, Denis, Coste, André, de Blay, Frédéric, Devillier, Philippe, Didier, Alain, Dinh-Xuan, Anh Tuan, Fontaine, Jean-François, Just, Jocelyne, Nadif, Rachel, Pham-Thi, Nhân, Pigearias, Bernard, Roche, Nicolas, Ganse Eric, Van, Chkhartishvili, Ekaterine, Gamkrelidze, Amiran, Gotua, Maia, Becker, Sven, Bergmann, Karl-Christian, Bieber, Thomas, Brehler, Randolf, Buhl, Roland, Chaker, Adam M., Darsow, Ulf, Hamelmann, Eckard, Heinrich, Joachim, Keil, Thomas, Klimek, Ludger, Kolkhir, Pavel, Lau, Susanne, Maurer, Marcus, Mösges, Ralph, Neou, Angelos, Pfaar, Oliver, Ring, Johannes, Wagenmann, Martin, Zuberbier, Torsten, Ramanauskaite, Aiste, Lingnau, Anja, Christou, Demetrios, Neisinger, Sophia, Aggelidis, Xenophon, Constantinidis, Jannis, Dimou, Maria, Grigoreas, Christos, Kapsali, Trisevgeni, Katotomichelakis, Michael, Loukides, Stelios, Makris, Michael, Manousakis, Emmanouil, Mikos, Nikolaos, Pagkalos, Aris, Papadopoulos, Nikolaos G., Papanikolaou, Vasileios, Paraskevopoulos, Giannis, Piskou, Konstantina, Prokopakis, Emmanuel, Psarros, Fotios, Samitas, Konstantinos, Stamataki, Sofia, Stefanaki Lina, Evangelia, Syrigou, Ekaterini, Tsiligianni, Ioanna, Vallianatou, Mina, Vourdas, Dimitrios, Xepapadaki, Paraskevi, Karavelia, Aspasia, Wai San Ko, Fanny, Wong, Gary, Hirschberg, Andor, Kraxner, Helga, Nekam, Kristof, Lane, Stephen, Rottem, Menachem, Artesani Maria, Cristina, Barbaglia, Simona, Beghé, Bianca, Bilo Maria, Beatrice, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Braido, Fulvio, Brussino, Luisa, Canonica, G Walter, Cecchi, Lorenzo, Ciprandi, Giorgio, Compalati, Enrico, D'Amato, Gennaro, De Feo, Giulia, Del Giacco, Stefano, Fiocchi, Alessandro, Heffler, Enrico, Lombardi, Carlo, Monti, Riccardo, Muraro, Antonella, Nettis, Eustachio, Nicola, Stefania, Passalacqua, Giovanni, Patella, Vincenzo, Puggioni, Francesca, Rolla, Giovanni, Romano, Antonino, Scichilone, Nicola, Triggiani, Massimo, Ventura Maria, Teresa, Viegi, Giovanni, Boccabella, Cristina, Giovannini, Mattia, Mahesh Padukudru, Anand, Iinuma, Tomohisa, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimihiro, Pawankar, Ruby, Sakurai, Daiju, Suzukawa, Maho, Yamaguchi, Masao, Ispayeva, Zhanat, Chang, Yoon-Seok, Park, Hae-Sim, Al-Ahmad, Mona, Cirule, Ieva, Grisle, Ineta, Irani, Carla, Rouadi, Philip, Zaitoun, Fares, Dubakiene, Ruta, Emuzyte, Regina, Kvedariene, Violeta, Gradauskiene, Brigita, Valiulis, Arunas, Ollert, Markus, Hannachi, Farah, Dokic, Dejan, Abdul Latiff, Amir Hamzah, Abdullah, Baharudin, Palaniappan, S.P., Woo, Kent, Montefort, Stephen, Bedolla Barajas, Martín, Costa Domínguez, María del Carmen, Espinoza Contreras, Jesús Guillermo, Fuentes Pèrez, Jose Miguel, Gálvez Romero, José Luis, García Cruz, María de la Luz Hortensia, González Diaz, Sandra, Huerta Villalobos, Yunuen Rocío, Larenas-Linnemann, Désiree E., Luna-Pech, Jorge Agustin, Matta Campos, Juan José, Rivero Yeverino, Daniela, Rodríguez González, Mónica, Rodríguez Zagal, Eréndira, Lkhagvaa, Battur, Mavale-Manuel, Sandra, Nunes Elizabete, Abrantes, Chavannes, Niels, Fokkens, Wytske J., Koppelman, Gerard, Maitland-van der Zee, Anke-Hilse, Reitsma, Sietze, Chandrasekharan, Ramanathan, Yusuf, Osman, Repka-Ramirez, Maria Susana, Sisul, Juan Carlos, Gereda, José E., Recto, Marysia T., Bialek, Slawomir, Bialoszewski, Artur, Chelminska, Marta, Gawlik, Radoslaw, Jassem, Ewa, Jutel, Marek, Kuna, Piotr, Kupczyk, Maciej, Moniuszko, Marcin, Niedoszytko, Marek, Raciborski, Filip, Romantowski, Jan, Samolinski, Boleslaw, Specjalski, Krzysztof, Carreiro Martins, Pedro, Correia de Sousa, Jaime, Costa, Elisio, Fonseca, Joao A., Lourenço, Olga, Morais-Almeida, Mario, Pereira Ana, Margarida, Regateiro, Frederico, Robalo Cordeiro, Carlos, Rosado Pinto, Jose, Sousa-Pinto, Bernardo, Taborda Barata, Luis, Todo-Bom, Ana Maria, Vieira Rafael, José, Carvalho, Daniela, Al-Nesf, Maryam Ali, Agache, Ioana, Berghea Elena, Camelia, Bumbacea, Roxana, Deleanu, Diana, Mihaltan, Florin, Panaitescu Bunu, Carmen, Khaitov, Musa, Namazova-Baranova, Leyla, Vishneva, Elena, Alshaikh Nada, Ali, Dimic-Janjic, Sanja, Milenkovic, Branislava, Wang, De Yun, Hrubiško, Martin, Edelbaher, Natalija, Jošt, Maja, Kopac, Peter, Košnik, Mitja, Lalek, Nika, Poplas Susic, Antonija, Rozman Sinur, Irma, Soklic Košak, Tanja, Triller, Nadja, Triller, Katja, Urbancic, Jure, Zidarn, Mihaela, Levin, Michael, Potter, Paul, Zar, Heather, Alobid, Isam, Anto, Aram, Bartra, Joan, Bobolea, Irina, Campo, Paloma, Cardona, Vicky, Carriazo Ana, Maria, Castillo Vizuete, José Antonio, Chivato, Tomas, Davila Gonzalez, Ignacio Jesus, Mullol, Joaquim, Nieto Garcia, Antonio, Picado, César, Quirce, Santiago, Sastre, Joaquin, de las Vecillas, Leticia, Benson, Mikael, Kull, Inger, van Hage, Marianne, Wickman, Magnus, Khaltaev, Nikolai, Mohammad, Yousser, Tantilipikorn, Pongsakorn, Vichyanond, Pakit, Cingi, Cemal, Gemicioglu, Bilun, Goksel, Ozlem, Kalayci, Omer, Kalyoncu, Ali Fuat, Meço, Cem, Vardaloglu, Koyuncu Ilgim, Yorgancioglu, Arzu, Karabacak, Deniz Eyice, Kirenga, Bruce, Adcock, Ian Michael, Arshad, Hasan S., Bewick, Mike, Bond, Christine, Brightling, Christopher, Bush, Andrew, Calderon, Moïses, Chung, Kian Fan, Custovic, Adnan, Djukanovic, Ratko, Durham, Stephen, Farrell, John, Halpin, David, Hyland, Michael, Johnston, Sebastian, Lipworth, Brian, Nakonechna, Alla, Price, David, Roberts, Graham, Ryan, Dermot, Schwarze, Jürgen, Sheikh, Aziz, Shields, Mike, Walker, Samantha, Williams, Sian, Kaidashev, Igor, Kurchenko, Andrii Igorevich, Tsaryk, Vladyslav, Bernstein, David, Bernstein, Jonathan A., Casale, Thomas B., Chinthrajah, Sharon, Dykewicz, Mark, Marshall, Gailen D., Meltzer, Eli O., Naclerio, Robert M., Togias, Alkis, Toskala, Elina, Wallace, Dana, Williams, Dennis M., Yawn, Barbara, Caballero-Fonseca, Fernan, Le Thi Tuyet, Lan, Vu, Tran Thien Quan, Gil-Mata, Sara, Teixeira, Tatiana, Bedbrook, Anna, Bousquet, Jean, and Vieira, Rafael José
- Published
- 2024
- Full Text
- View/download PDF
49. Dupilumab Efficacy in Children With Type 2 Asthma Receiving High- to Medium-Dose Inhaled Corticosteroids (VOYAGE)
- Author
-
Maspero, Jorge F., Antila, Martti A., Deschildre, Antoine, Bacharier, Leonard B., Altincatal, Arman, Laws, Elizabeth, Mortensen, Eric, Radwan, Amr, Jacob-Nara, Juby A., Deniz, Yamo, Rowe, Paul J., Lederer, David J., and Hardin, Megan
- Published
- 2024
- Full Text
- View/download PDF
50. Benjamin-Feir instability of Stokes waves in finite depth
- Author
-
Berti, Massimiliano, Maspero, Alberto, and Ventura, Paolo
- Subjects
Mathematics - Analysis of PDEs - Abstract
Whitham and Benjamin predicted in 1967 that small-amplitude periodic traveling Stokes waves of the 2d-gravity water waves equations are linearly unstable with respect to long-wave perturbations, if the depth $\mathtt h$ is larger than a critical threshold $\mathtt h_{WB} \approx 1.363$. In this paper we completely describe, for any value of $\mathtt h > 0$, the four eigenvalues close to zero of the linearized equations at the Stokes wave, as the Floquet exponent $\mu$ is turned on. We prove in particular the existence of a unique depth $\mathtt h_{WB}$, which coincides with the one predicted by Whitham and Benjamin, such that, for any $0 < \mathtt h < \mathtt h_{WB}$, the eigenvalues close to zero remain purely imaginary and, for any $\mathtt h > \mathtt h_{WB}$, a pair of non-purely imaginary eigenvalues depicts a closed figure "8", parameterized by the Floquet exponent. As $\mathtt h \to \mathtt h_{WB}^+$ this figure "8" collapses to the origin of the complex plane. The proof combines a symplectic version of Kato's perturbative theory to compute the eigenvalues of a $4 \times 4$ Hamiltonian and reversible matrix, and KAM inspired transformations to block-diagonalize it. The four eigenvalues have all the same size $O(\mu)$ - unlike the infinitely deep water case in [6]- and the correct Benjamin-Feir phenomenon appears only after one non-perturbative block-diagonalization step. In addition one has to track, along the whole proof, the explicit dependence of the entries of the $4 \times 4$ reduced matrix with respect to the depth $\mathtt h$., Comment: 47 pages, 5 figures, revised introduction. arXiv admin note: substantial text overlap with arXiv:2109.11852
- Published
- 2022
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.