1,719 results on '"Mason, R P"'
Search Results
2. Methanogenic patterns in the gut microbiome are associated with survival in a population of feral horses
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Stothart, Mason. R., McLoughlin, Philip. D., Medill, Sarah. A., Greuel, Ruth. J., Wilson, Alastair. J., and Poissant, Jocelyn.
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- 2024
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3. Kinematic scheme study of the $O(a^4)$ Bjorken sum rule and R ratio
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Mason, R. H. and Gracey, J. A.
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High Energy Physics - Phenomenology - Abstract
The Bjorken sum rule and R ratio are constructed to $O(a^4)$ in the Landau gauge in the three momentum subtraction schemes of Celmaster and Gonsalves where $a$ $=$ $g^2/(16\pi^2)$. We aim to examine the issue of convergence for observables in the various schemes as well as to test ideas on whether using the discrepancy in different scheme values is a viable and more quantum field theoretic alternative to current ways of estimating the theory error on a measureable., Comment: 48 latex pages, 9 tables, 18 figures, anc directory contains a txt file with the electronic version of Bjorken sum rule and R ratio in different kinematic schemes, minor text changes
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- 2023
4. Crewther's relation in different schemes
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Mason, R. H. and Gracey, J. A.
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High Energy Physics - Phenomenology - Abstract
We examine Crewther's relation at high loop order in perturbative QCD and demonstrate how the relation is accommodated in gauge-parameter dependent schemes where the running of the gauge parameter has to be explicitly considered. Motivated by ensuring that the conformal properties of the relation are preserved at all the critical points of QCD, including the Banks-Zaks and its infra-red stable twin, we demonstrate the necessity of an additional term in the relation for describing gauge running in the minimal momentum subtraction scheme (mMOM) and argue for its inclusion for all gauge-parameter dependent schemes., Comment: 10 latex pages, 2 tables, 1 figure, proceedings of RADCOR2023
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- 2023
5. New rabies viral resources for multi-scale neural circuit mapping
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Bouin, Alexis, Wu, Ginny, Koyuncu, Orkide O, Ye, Qiao, Kim, Keun-Young, Wu, Michele Y, Tong, Liqi, Chen, Lujia, Phan, Sebastien, Mackey, Mason R, Ramachandra, Ranjan, Ellisman, Mark H, Holmes, Todd C, Semler, Bert L, and Xu, Xiangmin
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Biomedical and Clinical Sciences ,Clinical Sciences ,Acquired Cognitive Impairment ,Bioengineering ,Neurosciences ,Brain Disorders ,Dementia ,Prevention ,Biomedical Imaging ,Aging ,Infection ,Neurological ,Good Health and Well Being ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
Comparisons and linkage between multiple imaging scales are essential for neural circuit connectomics. Here, we report 20 new recombinant rabies virus (RV) vectors that we have developed for multi-scale and multi-modal neural circuit mapping tools. Our new RV tools for mesoscale imaging express a range of improved fluorescent proteins. Further refinements target specific neuronal subcellular locations of interest. We demonstrate the discovery power of these new tools including the detection of detailed microstructural changes of rabies-labeled neurons in aging and Alzheimer's disease mouse models, live imaging of neuronal activities using calcium indicators, and automated measurement of infected neurons. RVs that encode GFP and ferritin as electron microscopy (EM) and fluorescence microscopy reporters are used for dual EM and mesoscale imaging. These new viral variants significantly expand the scale and power of rabies virus-mediated neural labeling and circuit mapping across multiple imaging scales in health and disease.
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- 2024
6. Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial.
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Black, Lora, Boggess, Blake, Chatterjee, Paramita, Chung, Christine, Easley, Kirk, Gibson, Greg, Hackel, Josh, Jensen, Katie, Kippner, Linda, Kurtenbach, Chad, Kurtzberg, Joanne, Mason, R, Noonan, Benjamin, Roy, Krishnendu, Valentine, Verle, Yeago, Carolyn, Drissi, Hicham, Mautner, Ken, Gottschalk, Michael, Boden, Scott, Akard, Alison, and Bae, Won
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Various types of cellular injection have become a popular and costly treatment option for patients with knee osteoarthritis despite a paucity of literature establishing relative efficacy to each other or corticosteroid injections. Here we aimed to identify the safety and efficacy of cell injections from autologous bone marrow aspirate concentrate, autologous adipose stromal vascular fraction and allogeneic human umbilical cord tissue-derived mesenchymal stromal cells, in comparison to corticosteroid injection (CSI). The study was a phase 2/3, four-arm parallel, multicenter, single-blind, randomized, controlled clinical trial with 480 patients with a diagnosis of knee osteoarthritis (Kellgren-Lawrence II-IV). Participants were randomized to the three different arms with a 3:1 distribution. Arm 1: autologous bone marrow aspirate concentrate (n = 120), CSI (n = 40); arm 2: umbilical cord tissue-derived mesenchymal stromal cells (n = 120), CSI (n = 40); arm 3: stromal vascular fraction (n = 120), CSI (n = 40). The co-primary endpoints were the visual analog scale pain score and Knee injury and Osteoarthritis Outcome Score pain score at 12 months versus baseline. Analyses of our primary endpoints, with 440 patients, revealed that at 1 year post injection, none of the three orthobiologic injections was superior to another, or to the CSI control. In addition, none of the four groups showed a significant change in magnetic resonance imaging osteoarthritis score compared to baseline. No procedure-related serious adverse events were reported during the study period. In summary, this study shows that at 1 year post injection, there was no superior orthobiologic as compared to CSI for knee osteoarthritis. ClinicalTrials.gov Identifier: NCT03818737.
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- 2023
7. The Crewther relation, schemes, gauges and fixed points
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Gracey, J. A. and Mason, R. H.
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High Energy Physics - Phenomenology - Abstract
We investigate the Crewther relation at high loop order in a variety of renormalization schemes and gauges. By examining the properties of the relation in schemes other than modified minimal subtraction (MSbar) at the fixed points of Quantum Chromodynamics we propose a generalization of the Crewther relation that extends the MSbar construction of Broadhurst and Kataev. A derivation based on the properties of the renormalization group equation is provided for the generalization which is tested in various scenarios., Comment: 51 latex pages, 10 tables, anc directory contains additional tables and a txt file with the electronic version of results for a general colour group, minor text changes and additional references
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- 2023
8. Scheme and gauge dependence of QCD fixed points at five loops
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Gracey, J. A., Mason, R. H., Ryttov, Thomas A., and Simms, R. M.
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High Energy Physics - Phenomenology - Abstract
We analyse the fixed points of QCD at high loop order in a variety of renormalization schemes and gauges across the conformal window. We observe that in the minimal momentum subtraction scheme solutions for the Banks-Zaks fixed point persist for values of Nf below that of the MSbar scheme in the canonical linear covariant gauge. By treating the parameter of the linear covariant gauge as a second coupling constant we confirm the existence of a second Banks-Zaks twin critical point, which is infrared stable, to five loops. Moreover a similar and parallel infrared stable fixed point is present in the Curci-Ferrari and maximal abelian gauges which persists in different schemes including kinematic ones. We verify that with the increased available loop order critical exponent estimates show an improvement in convergence and agreement in the various schemes., Comment: 56 latex pages, 11 figures, 34 tables, anc directory contains pdf of additional tables, minor text additions
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- 2023
9. Upper Bounds for Covering Arrays of Higher Index
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Calbert, Mason R. and Dougherty, Ryan E.
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Mathematics - Combinatorics ,Computer Science - Discrete Mathematics - Abstract
A \emph{covering array} is an $N \times k$ array of elements from a $v$-ary alphabet such that every $N \times t$ subarray contains all $v^t$ tuples from the alphabet of size $t$ at least $\lambda$ times; this is denoted as $\CA_\lambda(N; t, k, v)$. Covering arrays have applications in the testing of large-scale complex systems; in systems that are nondeterministic, increasing $\lambda$ gives greater confidence in the system's correctness. The \emph{covering array number}, $\CAN_\lambda(t,k,v)$ is the smallest number of rows for which a covering array on the other parameters exists. For general $\lambda$, only several nontrivial bounds are known, the smallest of which was asymptotically $\log k + \lambda \log \log k + o(\lambda)$ when $v, t$ are fixed. Additionally it has been conjectured that the $\log \log k$ term can be removed. First, we affirm the conjecture by deriving an asymptotically optimal bound for $\CAN_\lambda(t,k,v)$ for general $\lambda$ and when $v, t$ are constant using the Stein--Lov\'asz--Johnson paradigm. Second, we improve upon the constants of this method using the Lov\'asz local lemma. Third, when $\lambda=2$, we extend a two-stage paradigm of Sarkar and Colbourn that improves on the general bound and often produces better bounds than even when $\lambda=1$ of other results. Fourth, we extend this two-stage paradigm further for general $\lambda$ to obtain an even stronger upper bound, including using graph coloring. And finally, we determine a bound on how large $\lambda$ can be for when the number of rows is fixed., Comment: 19 pages
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- 2022
10. Five loop minimal MOM scheme field and quark mass anomalous dimensions in QCD
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Gracey, J. A. and Mason, R. H.
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High Energy Physics - Phenomenology - Abstract
We determine the anomalous dimensions of the gluon, Faddeev-Popov ghost and quark in the minimal MOM scheme to five loops for a general colour group when Quantum Chromodynamics is fixed in a linear covariant gauge. The quark mass anomalous dimension is also constructed in the same scheme., Comment: 21 latex pages, anc directory contains txt file with electronic version of anomalous dimensions for the mini-MOM scheme and their conversion functions, clarifications and minor changes added
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- 2022
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11. Potential effects of icosapent ethyl on cardiovascular outcomes in cigarette smokers: REDUCE-IT smoking
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Miller, Michael, Bhatt, Deepak L, Steg, Ph Gabriel, Brinton, Eliot A, Jacobson, Terry A, Jiao, Lixia, Tardif, Jean-Claude, Ballantyne, Christie M, Budoff, Matthew, and Mason, R Preston
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Tobacco ,Clinical Trials and Supportive Activities ,Prevention ,Heart Disease ,Clinical Research ,Tobacco Smoke and Health ,Patient Safety ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Stroke ,Good Health and Well Being ,Humans ,Eicosapentaenoic Acid ,Myocardial Infarction ,Tobacco Products ,Smoking ,Cigarette smoking ,Icosapent ethyl ,Hypertriglyceridemia ,Reduce-IT ,Clinical trial ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology ,Pharmacology and pharmaceutical sciences - Abstract
AimsCigarette smoking is among the most well-established risk factors for adverse cardiovascular outcomes. We sought to determine whether icosapent ethyl (IPE), a highly purified form of eicosapentaenoic acid with antiatherothrombotic properties, may reduce the excessive risk of cardiovascular disease (CVD) attributable to smoking.Methods and resultsReduction of Cardiovascular Events with Icosapent Ethyl Trial (REDUCE-IT) was a multinational, double-blind trial that randomized 8179 statin-treated patients with elevated triglycerides and CV risk to IPE or placebo, with a median follow-up period of 4.9 years. Icosapent ethyl reduced the primary composite endpoint [CV death, non-fatal myocardial infarction (MI), non-fatal stroke, coronary revascularization, or hospitalization for unstable angina] by 25% (P
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- 2023
12. Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection
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Firpo, Mason R, LoMascolo, Natalie J, Petit, Marine J, Shah, Priya S, and Mounce, Bryan C
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Medical Microbiology ,Biomedical and Clinical Sciences ,Biological Sciences ,Biotechnology ,Genetics ,Infectious Diseases ,Infection ,Humans ,Enterovirus ,Polyamines ,Virus Replication ,Enterovirus Infections ,Coxsackievirus Infections ,Enterovirus B ,Human ,Microbiology ,Immunology ,Virology ,Medical microbiology - Abstract
Metabolism is key to cellular processes that underlie the ability of a virus to productively infect. Polyamines are small metabolites vital for many host cell processes including proliferation, transcription, and translation. Polyamine depletion also inhibits virus infection via diverse mechanisms, including inhibiting polymerase activity and viral translation. We showed that Coxsackievirus B3 (CVB3) attachment requires polyamines; however, the mechanism was unknown. Here, we report polyamines' involvement in translation, through a process called hypusination, promotes expression of cholesterol synthesis genes by supporting SREBP2 synthesis, the master transcriptional regulator of cholesterol synthesis genes. Measuring bulk transcription, we find polyamines support expression of cholesterol synthesis genes, regulated by SREBP2. Thus, polyamine depletion inhibits CVB3 by depleting cellular cholesterol. Exogenous cholesterol rescues CVB3 attachment, and mutant CVB3 resistant to polyamine depletion exhibits resistance to cholesterol perturbation. This study provides a novel link between polyamine and cholesterol homeostasis, a mechanism through which polyamines impact CVB3 infection.
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- 2023
13. Role of Omega-3 Fatty Acids in Cardiovascular Disease: the Debate Continues
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Sherratt, Samuel CR, Libby, Peter, Budoff, Matthew J, Bhatt, Deepak L, and Mason, R Preston
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Cardiovascular ,Heart Disease ,Clinical Research ,Clinical Trials and Supportive Activities ,Complementary and Integrative Health ,Prevention ,Heart Disease - Coronary Heart Disease ,Atherosclerosis ,Prevention of disease and conditions ,and promotion of well-being ,3.3 Nutrition and chemoprevention ,Aetiology ,2.1 Biological and endogenous factors ,Humans ,Cardiovascular Diseases ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Hypertriglyceridemia ,Fatty Acids ,Omega-3 ,Docosahexaenoic Acids ,Cholesterol ,Triglycerides ,Plaque ,Atherosclerotic ,Eicosapentaenoic acid ,Lipoproteins ,Omega-3 fatty acids ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
Purpose of reviewThe omega-3 fatty acids (n3-FAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have recently undergone testing for their ability to reduce residual cardiovascular (CV) risk among statin-treated subjects. The outcome trials have yielded highly inconsistent results, perhaps attributable to variations in dosage, formulation, and composition. In particular, CV trials using icosapent ethyl (IPE), a highly purified ethyl ester of EPA, reproducibly reduced CV events and progression of atherosclerosis compared with mixed EPA/DHA treatments. This review summarizes the mechanistic evidence for differences among n3-FAs on the development and manifestations of atherothrombotic disease.Recent findingsLarge randomized clinical trials with n3-FAs have produced discordant outcomes despite similar patient profiles, doses, and triglyceride (TG)-lowering effects. A large, randomized trial with IPE, a prescription EPA only formulation, showed robust reduction in CV events in statin treated patients in a manner proportional to achieved blood EPA concentrations. Multiple trials using mixed EPA/DHA formulations have not shown such benefits, despite similar TG lowering. These inconsistencies have inspired investigations into mechanistic differences among n3-FAs, as EPA and DHA have distinct membrane interactions, metabolic products, effects on cholesterol efflux, antioxidant properties, and tissue distribution. EPA maintains normal membrane cholesterol distribution, enhances endothelial function, and in combination with statins improves features implicated in plaque stability and reduces lipid content of plaques. Insights into reductions in residual CV risk have emerged from clinical trials using different formulations of n3-FAs. Among high-risk patients on contemporary care, mixed n3-FA formulations showed no reduction in CV events. The distinct benefits of IPE in multiple trials may arise from pleiotropic actions that correlate with on-treatment EPA levels beyond TG-lowering. These effects include altered platelet function, inflammation, cholesterol distribution, and endothelial dysfunction. Elucidating such mechanisms of vascular protection for EPA may lead to new interventions for atherosclerosis, a disease that continues to expand worldwide.
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- 2023
14. Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial
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Mautner, Ken, Gottschalk, Michael, Boden, Scott D., Akard, Alison, Bae, Won C., Black, Lora, Boggess, Blake, Chatterjee, Paramita, Chung, Christine B., Easley, Kirk A., Gibson, Greg, Hackel, Josh, Jensen, Katie, Kippner, Linda, Kurtenbach, Chad, Kurtzberg, Joanne, Mason, R. Amadeus, Noonan, Benjamin, Roy, Krishnendu, Valentine, Verle, Yeago, Carolyn, and Drissi, Hicham
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- 2023
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15. Benefits of Icosapent Ethyl Across the Range of Kidney Function in Patients With Established Cardiovascular Disease or Diabetes: REDUCE-IT RENAL
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Majithia, Arjun, Bhatt, Deepak L, Friedman, Allon N, Miller, Michael, Steg, Ph Gabriel, Brinton, Eliot A, Jacobson, Terry A, Ketchum, Steven B, Juliano, Rebecca A, Jiao, Lixia, Doyle, Ralph T, Granowitz, Craig, Budoff, Matthew, Mason, R Preston, Tardif, Jean-Claude, Boden, William E, and Ballantyne, Christie M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Cardiovascular ,Clinical Trials and Supportive Activities ,Clinical Research ,Diabetes ,Prevention ,Kidney Disease ,Heart Disease ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Good Health and Well Being ,Aged ,Cardiovascular Diseases ,Double-Blind Method ,Eicosapentaenoic Acid ,Female ,Glomerular Filtration Rate ,Humans ,Male ,Middle Aged ,Renal Insufficiency ,Chronic ,eicosapentaenoic acid ethyl ester ,fatty acids ,omega-3 ,lipids ,prevention and control ,renal insufficiency ,chronic ,triglycerides ,fatty acids ,omega-3 ,renal insufficiency ,chronic ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Sports science and exercise - Abstract
BackgroundChronic kidney disease is associated with adverse outcomes among patients with established cardiovascular disease (CVD) or diabetes. Commonly used medications to treat CVD are less effective among patients with reduced kidney function.MethodsREDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial) was a multicenter, double-blind, placebo-controlled trial that randomly assigned statin-treated patients with elevated triglycerides (135-499 mg/dL) who had CVD or diabetes and 1 additional risk factor to treatment with icosapent ethyl (4 g daily) or placebo. Patients from REDUCE-IT were categorized by prespecified estimated glomerular filtration rate (eGFR) categories to analyze the effect of icosapent ethyl on the primary end point (composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or unstable angina) and key secondary end point (a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke).ResultsAmong the 8179 REDUCE-IT patients, median baseline eGFR was 75 mL·min-1·1.73 m-2 (range, 17-123 mL·min-1·1.73 m-2). There were no meaningful changes in median eGFR for icosapent ethyl versus placebo across study visits. Treatment with icosapent ethyl led to consistent reduction in both the primary and key secondary composite end points across baseline eGFR categories. Patients with eGFR
- Published
- 2021
16. Elemental mapping of labelled biological specimens at intermediate energy loss in an energy‐filtered TEM acquired using a direct detection device
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Ramachandra, Ranjan, Mackey, Mason R, Hu, Junru, Peltier, Steven T, Xuong, Nguyen‐Huu, Ellisman, Mark H, and Adams, Stephen R
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Chemical Sciences ,Physical Chemistry ,Biotechnology ,Diagnostic Imaging ,Electrons ,Lanthanoid Series Elements ,Microscopy ,Energy-Filtering Transmission Electron ,Staining and Labeling ,colour EM ,DAB ,DDD ,direct detection device ,EFTEM ,intermediate loss ,lanthanide DAB ,low loss ,spectrum imaging ,Condensed Matter Physics ,Biochemistry and Cell Biology ,Materials Engineering ,Microscopy ,Biochemistry and cell biology ,Physical chemistry ,Materials engineering - Abstract
The technique of colour EM that was recently developed enabled localisation of specific macromolecules/proteins of interest by the targeted deposition of diaminobenzidine (DAB) conjugated to lanthanide chelates. By acquiring lanthanide elemental maps by energy-filtered transmission electron microscopy (EFTEM) and overlaying them in pseudo-colour over the conventional greyscale TEM image, a colour EM image is generated. This provides a powerful tool for visualising subcellular component/s, by the ability to clearly distinguish them from the general staining of the endogenous cellular material. Previously, the lanthanide elemental maps were acquired at the high-loss M4,5 edge (excitation of 3d electrons), where the characteristic signal is extremely low and required considerably long exposures. In this paper, we explore the possibility of acquiring the elemental maps of lanthanides at their N4,5 edge (excitation of 4d electrons), which occurring at a much lower energy-loss regime, thereby contains significantly greater total characteristic signal owing to the higher inelastic scattering cross-sections at the N4,5 edge. Acquiring EFTEM lanthanide elemental maps at the N4,5 edge instead of the M4,5 edge, provides ∼4× increase in signal-to-noise and ∼2× increase in resolution. However, the interpretation of the lanthanide maps acquired at the N4,5 edge by the traditional 3-window method, is complicated due to the broad shape of the edge profile and the lower signal-above-background ratio. Most of these problems can be circumvented by the acquisition of elemental maps with the more sophisticated technique of EFTEM Spectrum Imaging (EFTEM SI). Here, we also report the chemical synthesis of novel second-generation DAB lanthanide metal chelate conjugates that contain 2 lanthanide ions per DAB molecule in comparison with 0.5 lanthanide ion per DAB in the first generation. Thereby, fourfold more Ln3+ per oxidised DAB would be deposited providing significant amplification of signal. This paper applies the colour EM technique at the intermediate-loss energy-loss regime to three different cellular targets, namely using mitochondrial matrix-directed APEX2, histone H2B-Nucleosome and EdU-DNA. All the examples shown in the paper are single colour EM images only.
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- 2021
17. Rescue of High Glucose Impairment of Cultured Human Osteoblasts Using Cinacalcet and Parathyroid Hormone
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Shahen, V. A., Schindeler, A., Rybchyn, M. S., Girgis, C. M., Mulholland, B., Mason, R. S., Levinger, I., and Brennan-Speranza, T. C.
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- 2023
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18. A Revolution in Omega-3 Fatty Acid Research ∗
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Bhatt, Deepak L, Budoff, Matthew J, and Mason, R Preston
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Eicosapentaenoic Acid ,Fatty Acids ,Omega-3 ,Humans ,Hypertriglyceridemia ,Myocardial Infarction ,eicosapentaenoic acid ,icosapent ethyl ,omega-3 fatty acid ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Published
- 2020
19. Iron-specific Signal Separation from within Heavy Metal Stained Biological Samples Using X-Ray Microtomography with Polychromatic Source and Energy-Integrating Detectors.
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Katchalski, Tsvi, Case, Tom, Kim, Keun-Young, Ramachandra, Ranjan, Bushong, Eric A, Deerinck, Thomas J, Haberl, Matthias G, Mackey, Mason R, Peltier, Steven, Castillon, Guillaume A, Fujikawa, Nobuko, Lawrence, Albert R, and Ellisman, Mark H
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Axons ,Spinal Nerve Roots ,Animals ,Mice ,Metals ,Heavy ,Iron ,Staining and Labeling ,Phantoms ,Imaging ,X-Ray Microtomography ,Metals ,Heavy ,Phantoms ,Imaging - Abstract
Biological samples are frequently stained with heavy metals in preparation for examining the macro, micro and ultra-structure using X-ray microtomography and electron microscopy. A single X-ray microtomography scan reveals detailed 3D structure based on staining density, yet it lacks both material composition and functional information. Using a commercially available polychromatic X-ray source, energy integrating detectors and a two-scan configuration labelled by their energy- "High" and "Low", we demonstrate how a specific element, here shown with iron, can be detected from a mixture with other heavy metals. With proper selection of scan configuration, achieving strong overlap of source characteristic emission lines and iron K-edge absorption, iron absorption was enhanced enabling K-edge imaging. Specifically, iron images were obtained by scatter plot material analysis, after selecting specific regions within scatter plots generated from the "High" and "Low" scans. Using this method, we identified iron rich regions associated with an iron staining reaction that marks the nodes of Ranvier along nerve axons within mouse spinal roots, also stained with osmium metal commonly used for electron microscopy.
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- 2018
20. The complex, dusty narrow-line region of NGC 4388: Gas-jet interactions, outflows, and extinction revealed by near-IR spectroscopy
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Rodriguez-Ardila, A., Mason, R. E., Martins, L., Almeida, C. Ramos, Riffel, R. A., Riffel, R., Lira, P., Martin, O. Gonzalez, Dametto, N. Z., Flohic, H., Ho, L. C., Ruschel-Dutra, D., Thanjavur, K., Colina, L., McDermid, R. M., Perlman, E., and Winge, C.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present Gemini/GNIRS spectroscopy of the Seyfert 2 galaxy NGC 4388, with simultaneous coverage from 0.85 - 2.5 $\mu$m. Several spatially-extended emission lines are detected for the first time, both in the obscured and unobscured portion of the optical narrow line region (NLR), allowing us to assess the combined effects of the central continuum source, outflowing gas and shocks generated by the radio jet on the central 280 pc gas. The HI and [FeII] lines allow us to map the extinction affecting the NLR. We found that the nuclear region is heavily obscured, with E(B-V) ~1.9 mag. To the NE of the nucleus and up to ~150 pc, the extinction remains large, ~1 mag or larger, consistent with the system of dust lanes seen in optical imaging. We derived position-velocity diagrams for the most prominent lines as well as for the stellar component. Only the molecular gas and the stellar component display a well-organized pattern consistent with disk rotation. Other emission lines are kinematically perturbed or show little evidence of rotation. Extended high-ionization emission of sulfur, silicon and calcium is observed to distances of at least 200 pc both NE and SW of the nucleus. We compared flux ratios between these lines with photoionization models and conclude that radiation from the central source alone cannot explain the observed high-ionization spectrum. Shocks between the radio-jet and the ambient gas are very likely an additional source of excitation. We conclude that NGC 4388 is a prime laboratory to study the interplay between all these mechanisms., Comment: 21 pages, 14 figures, 9 tables. Accepted for publication in MNRAS
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- 2016
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21. Radiographic Variants Associated With Allergic Fungal Rhinosinusitis: Key Differences for Pre-Operative Planning
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Erwin, Dylan Z., Liu, Matthew Y., Krysinski, Mason R., Choi, Alexander M., Tantiwongkosi, Bundhit, and Chen, Philip G.
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Objectives: Allergic fungal rhinosinusitis (AFRS) often results in expansion of disease beyond the paranasal sinuses, which may put important structures, such as the anterior ethmoid artery (AEA) or lateral lamella of the cribiform, at risk of injury during endoscopic sinus surgery (ESS). This study aims to compare the AEA to skull base (AEA-SB) length in patients with AFRS versus chronic rhinosinusitis with nasal polyps (CRSwNP), as well as additional anatomic variants.Methods: A single institutional retrospective chart review of patients undergoing ESS for AFRS and CRSwNP was performed. AEA-SB length were compared between the 2 groups. Other anatomic variants, including Keros measurement and presence of supraorbital ethmoid air cells (SOEC), concha bullosa (CB), sphenoethmoidal, and infraorbital ethmoid cells were measured and compared between the 2 groups.Results: Twenty-one patients were included in each cohort. The AFRS group was younger in age (P= .015) and had a significantly longer AEA-SB length (P= .014) compared to the CRSwNP group. No significant differences were observed between the 2 groups regarding Keros measurement, presence of concha bullosa, infraorbital ethmoid, sphenoethmoidal, or SOEC. No association was seen between AEA-SB length and Keros class in either group.Conclusions: AFRS harbors anatomical differences when compared to CRSwNP, with the former associated with a longer AEA-SB length. This key difference should be considered in preoperative planning to prevent injury to the AEA in patients undergoing ESS for AFRS.
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- 2025
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22. A mid-infrared spectroscopic atlas of local active galactic nuclei on sub-arcsecond resolution using GTC/CanariCam
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Alonso-Herrero, A., Esquej, P., Roche, P. F., Almeida, C. Ramos, Gonzalez-Martin, O., Packham, C., Levenson, N. A., Mason, R. E., Hernan-Caballero, A., Pereira-Santaella, M., Alvarez, C., Aretxaga, I., Lopez-Rodriguez, E., Colina, L., Diaz-Santos, T., Imanishi, M., Espinosa, J. M. Rodriguez, and Perlman, E.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present an atlas of mid-infrared (mid-IR) ~7.5-13micron spectra of 45 local active galactic nuclei (AGN) obtained with CanariCam on the 10.4m Gran Telescopio CANARIAS (GTC) as part of an ESO/GTC large program. The sample includes Seyferts and other low luminosity AGN (LLAGN) at a median distance of 35Mpc and luminous AGN, namely PG quasars, (U)LIRGs, and radio galaxies (RG) at a median distance of 254Mpc. To date, this is the largest mid-IR spectroscopic catalog of local AGN at sub-arcsecond resolution (median 0.3arcsec). The goal of this work is to give an overview of the spectroscopic properties of the sample. The nuclear 12micron luminosities of the AGN span more than four orders of magnitude, nu*Lnu(12micron)~ 3e41-1e46erg/s. In a simple mid-IR spectral index vs. strength of the 9.7micron silicate feature diagram most LLAGN, Seyfert nuclei, PG quasars, and RGs lie in the region occupied by clumpy torus model tracks. However, the mid-IR spectra of some might include contributions from other mechanisms. Most (U)LIRG nuclei in our sample have deeper silicate features and flatter spectral indices than predicted by these models suggesting deeply embedded dust heating sources and/or contribution from star formation. The 11.3micron PAH feature is clearly detected in approximately half of the Seyfert nuclei, LLAGN, and (U)LIRGs. While the RG, PG quasars, and (U)LIRGs in our sample have similar nuclear 12micron luminosities, we do not detect nuclear PAH emission in the RGs and PG quasars., Comment: Accepted for publication in MNRAS, 22 pages, 8 figures
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- 2015
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23. Outflowing Diffuse Gas in the Active Galactic Nucleus of NGC 1068
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Geballe, T. R., Mason, R. E., and Oka, T.
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Astrophysics - Astrophysics of Galaxies - Abstract
Spectra of the archetypal Type II Seyfert galaxy NGC 1068 in a narrow wavelength interval near 3.7 microns have revealed a weak absorption feature due to two lines of the molecular ion H3+. The observed wavelength of the feature corresponds to velocity of -70 km/s relative to the systemic velocity of the galaxy, implying an outward flow from the nucleus along the line of sight. The absorption by H3+ along with the previously known broad hydrocarbon absorption at 3.4~microns probably are formed in diffuse gas that is in close proximity to the continuum source, i.e. within a few tens of parsecs of the central engine. Based on that conclusion and the measured H3+ absorption velocity and with the assumption of a spherically symmetric wind we estimate a rate of mass outflow from the AGN of ~1 Msun/yr., Comment: Accepted by ApJ 2 Sep 2015
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- 2015
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24. Near-Infrared Polarimetric Adaptive Optics Observations of NGC 1068: A torus created by a hydromagnetic outflow wind
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Lopez-Rodriguez, E., Packham, C., Jones, T. J., Nikutta, R., McMaster, L., Mason, R. E., Elvis, M., Shenoy, D., Alonso-Herrero, A., Ramirez, E., Martin, O. Gonzalez, Hoenig, S. F., Levenson, N. A., Almeida, C. Ramos, and Perlman, E.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present J' and K' imaging linear polarimetric adaptive optics observations of NGC 1068 using MMT-Pol on the 6.5-m MMT. These observations allow us to study the torus from a magnetohydrodynamical (MHD) framework. In a 0.5" (30 pc) aperture at K', we find that polarisation arising from the passage of radiation from the inner edge of the torus through magnetically aligned dust grains in the clumps is the dominant polarisation mechanism, with an intrinsic polarisation of 7.0%$\pm$2.2%. This result yields a torus magnetic field strength in the range of 4$-$82 mG through paramagnetic alignment, and 139$^{+11}_{-20}$ mG through the Chandrasekhar-Fermi method. The measured position angle (P.A.) of polarisation at K$'$ is found to be similar to the P.A. of the obscuring dusty component at few parsec scales using infrared interferometric techniques. We show that the constant component of the magnetic field is responsible for the alignment of the dust grains, and aligned with the torus axis onto the plane of the sky. Adopting this magnetic field configuration and the physical conditions of the clumps in the MHD outflow wind model, we estimate a mass outflow rate $\le$0.17 M$_{\odot}$ yr$^{-1}$ at 0.4 pc from the central engine for those clumps showing near-infrared dichroism. The models used were able to create the torus in a timescale of $\geq$10$^{5}$ yr with a rotational velocity of $\leq$1228 km s$^{-1}$ at 0.4 pc. We conclude that the evolution, morphology and kinematics of the torus in NGC 1068 can be explained within a MHD framework., Comment: 14 pages, 4 figures, Accepted by MNRAS
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- 2015
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25. Strong near-infrared carbon in the Type Ia supernova iPTF13ebh
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Hsiao, E. Y., Burns, C. R., Contreras, C., Höflich, P., Sand, D., Marion, G. H., Phillips, M. M., Stritzinger, M., González-Gaitán, S., Mason, R. E., Folatelli, G., Parent, E., Gall, C., Amanullah, R., Anupama, G. C., Arcavi, I., Banerjee, D. P. K., Beletsky, Y., Blanc, G. A., Bloom, J. S., Brown, P. J., Campillay, A., Cao, Y., De Cia, A., Diamond, T., Freedman, W. L., Gonzalez, C., Goobar, A., Holmbo, S., Howell, D. A., Johansson, J., Kasliwal, M. M., Kirshner, R. P., Krisciunas, K., Kulkarni, S. R., Maguire, K., Milne, P. A., Morrell, N., Nugent, P. E., Ofek, E. O., Osip, D., Palunas, P., Perley, D. A., Persson, S. E., Piro, A. L., Rabus, M., Roth, M., Schiefelbein, J. M., Srivastav, S., Sullivan, M., Suntzeff, N. B., Surace, J., Woźnia, P. R., and Yaron, O.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present near-infrared (NIR) time-series spectroscopy, as well as complementary ultraviolet (UV), optical, and NIR data, of the Type Ia supernova (SN Ia) iPTF13ebh, which was discovered within two days from the estimated time of explosion. The first NIR spectrum was taken merely 2.3 days after explosion and may be the earliest NIR spectrum yet obtained of a SN Ia. The most striking features in the spectrum are several NIR C I lines, and the C I {\lambda}1.0693 {\mu}m line is the strongest ever observed in a SN Ia. Interestingly, no strong optical C II counterparts were found, even though the optical spectroscopic time series began early and is densely-cadenced. Except at the very early epochs, within a few days from the time of explosion, we show that the strong NIR C I compared to the weaker optical C II appears to be general in SNe Ia. iPTF13ebh is a fast decliner with {\Delta}m15(B) = 1.79 $\pm$ 0.01, and its absolute magnitude obeys the linear part of the width-luminosity relation. It is therefore categorized as a "transitional" event, on the fast-declining end of normal SNe Ia as opposed to subluminous/91bg-like objects. iPTF13ebh shows NIR spectroscopic properties that are distinct from both the normal and subluminous/91bg-like classes, bridging the observed characteristics of the two classes. These NIR observations suggest composition and density of the inner core similar to that of 91bg-like events, and a deep reaching carbon burning layer not observed in slower declining SNe Ia. There is also a substantial difference between the explosion times inferred from the early-time light curve and the velocity evolution of the Si II {\lambda}0.6355 {\mu}m line, implying a long dark phase of ~ 4 days., Comment: Accepted for Publication in Astronomy & Astrophysics. 17 figures and 19 pages
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- 2015
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26. The Nuclear Near-Infrared Spectral Properties of Nearby Galaxies
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Mason, R. E., Rodriguez-Ardila, A., Martins, L., Riffel, R., Martin, O. Gonzalez, Almeida, C. Ramos, Dutra, D. Ruschel, Ho, L. C., Thanjavur, K., Flohic, H., Alonso-Herrero, A., Lira, P., McDermid, R., Riffel, R. A., Schiavon, R. P., Winge, C., Hoenig, M. D., and Perlman, E.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present spectra of the nuclear regions of 50 nearby (D = 1 - 92 Mpc, median = 20 Mpc) galaxies of morphological types E to Sm. The spectra, obtained with the Gemini Near-IR Spectrograph on the Gemini North telescope, cover a wavelength range of approximately 0.85-2.5 microns at R~1300--1800. There is evidence that most of the galaxies host an active galactic nucleus (AGN), but the range of AGN luminosities (log (L2-10 keV [erg/s]) = 37.0-43.2) in the sample means that the spectra display a wide variety of features. Some nuclei, especially the Seyferts, exhibit a rich emission-line spectrum. Other objects, in particular the type 2 Low Ionisation Nuclear Emission Region galaxies, show just a few, weak emission lines, allowing a detailed view of the underlying stellar population. These spectra display numerous absorption features sensitive to the stellar initial mass function, as well as molecular bands arising in cool stars, and many other atomic absorption lines. We compare the spectra of subsets of galaxies known to be characterised by intermediate-age and old stellar populations, and find clear differences in their absorption lines and continuum shapes. We also examine the effect of atmospheric water vapor on the signal-to-noise ratio achieved in regions between the conventional NIR atmospheric windows, of potential interest to those planning observations of redshifted emission lines or other features affected by telluric H2O. Further exploitation of this data set is in progress, and the reduced spectra and data reduction tools are made available to the community., Comment: Accepted for publication in ApJS
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- 2015
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27. Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species.
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Adams, Stephen R, Mackey, Mason R, Ramachandra, Ranjan, Palida Lemieux, Sakina F, Steinbach, Paul, Bushong, Eric A, Butko, Margaret T, Giepmans, Ben NG, Ellisman, Mark H, and Tsien, Roger Y
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Hippocampus ,Astrocytes ,Cells ,Cultured ,Animals ,Mice ,Inbred BALB C ,Dogs ,Humans ,Lanthanoid Series Elements ,Microscopy ,Energy-Filtering Transmission Electron ,Male ,HEK293 Cells ,Cell-Penetrating Peptides ,Madin Darby Canine Kidney Cells ,diaminobenzidine photooxidation ,electron energy-loss spectroscopy ,electron microscopy ,lanthanide chelate ,multicolor ,peroxidase ,photosensitizer - Abstract
Electron microscopy (EM) remains the primary method for imaging cellular and tissue ultrastructure, although simultaneous localization of multiple specific molecules continues to be a challenge for EM. We present a method for obtaining multicolor EM views of multiple subcellular components. The method uses sequential, localized deposition of different lanthanides by photosensitizers, small-molecule probes, or peroxidases. Detailed view of biological structures is created by overlaying conventional electron micrographs with pseudocolor lanthanide elemental maps derived from distinctive electron energy-loss spectra of each lanthanide deposit via energy-filtered transmission electron microscopy. This results in multicolor EM images analogous to multicolor fluorescence but with the benefit of the full spatial resolution of EM. We illustrate the power of this methodology by visualizing hippocampal astrocytes to show that processes from two astrocytes can share a single synapse. We also show that polyarginine-based cell-penetrating peptides enter the cell via endocytosis, and that newly synthesized PKMζ in cultured neurons preferentially localize to the postsynaptic membrane.
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- 2016
28. The Gemini Observatory Fast Turnaround Program
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Mason, R. E., Cote, S., Kissler-Patig, M., Levenson, N. A., Adamson, A., Emmanuel, C., and Crabtree, D.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Gemini's Fast Turnaround program is intended to greatly decrease the time from having an idea to acquiring the supporting data. The scheme will offer monthly proposal submission opportunities, and proposals will be reviewed by the principal investigators or co-investigators of other proposals submitted during the same round. Here, we set out the design of the system and outline the plan for its implementation, leading to the launch of a pilot program at Gemini North in January 2015., Comment: SPIE proceedings
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- 2014
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29. Polarized Mid-Infrared Synchrotron Emission in the Core of Cygnus A
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Lopez-Rodriguez, E., Packham, C., Tadhunter, C., Mason, R., Perlman, E., Alonso-Herrero, A., Almeida, C. Ramos, Ichikawa, K., Levenson, N. A., Rodrıguez-Espinosa, J. M., Alvarez, C. A., Ramırez, E. A., and Telesco, C. M.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present high-angular (~0.4") resolution mid-infrared (MIR) polarimetric observations in the 8.7 ${\mu}$m and 11.6 ${\mu}$m filters of Cygnus A using CanariCam on the 10.4-m Gran Telescopio CANARIAS. A highly polarized nucleus is observed with a degree of polarization of 11${\pm}$3% and 12${\pm}$3% and position angle of polarization of 27${\pm}$8 degrees and 35${\pm}$8 degrees in a 0.38" (~380 pc) aperture for each filter. The observed rising of the polarized flux density with increasing wavelength is consistent with synchrotron radiation from the pc-scale jet close to the core of Cygnus A. Based on our polarization model, the synchrotron emission from the pc-scale jet is estimated to be 14% and 17% of the total flux density in the 8.7 ${\mu}$m and 11.6 ${\mu}$m filters, respectively. A blackbody component with a characteristic temperature of 220 K accounts for >75% of the observed MIR total flux density. The blackbody emission arises from a combination of (1) dust emission in the torus; and (2) diffuse dust emission around the nuclear region, but the contributions of the two components cannot be well constrained in these observations., Comment: 8 pages, 2 figures (Accepted for publication in ApJ)
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- 2014
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30. Nuclear 11.3$\mu$m PAH emission in local active galactic nuclei
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Alonso-Herrero, A., Almeida, C. Ramos, Esquej, P., Roche, P. F., Hernan-Caballero, A., Hoenig, S. F., Gonzalez-Martin, O., Aretxaga, I., Mason, R. E., Packham, C., Levenson, N. A., Espinosa, J. M. Rodriguez, Siebenmorgen, R., Pereira-Santaella, M., Diaz-Santos, T., Colina, L., Alvarez, C., and Telesco, C. M.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present Gran Telescopio CANARIAS CanariCam 8.7$\mu$m imaging and 7.5-13$\mu$m spectroscopy of six local systems known to host an active galactic nucleus (AGN) and have nuclear star formation. Our main goal is to investigate whether the molecules responsible for the 11.3$\mu$m polyclyclic aromatic hydrocarbon (PAH) feature are destroyed in the close vicinity of an AGN. We detect 11.3$\mu$m PAH feature emission in the nuclear regions of the galaxies as well as extended PAH emission over a few hundred parsecs. The equivalent width (EW) of the feature shows a minimum at the nucleus but increases with increasing radial distances, reaching typical star-forming values a few hundred parsecs away from the nucleus. The reduced nuclear EW are interpreted as due to increased dilution from the AGN continuum rather than destruction of the PAH molecules. We conclude that at least those molecules responsible for the 11.3$\mu$m PAH feature survive in the nuclear environments as close as 10pc from the AGN and for Seyfert-like AGN luminosities. We propose that material in the dusty tori, nuclear gas disks, and/or host galaxies of AGN is likely to provide the column densities necessary to protect the PAH molecules from the AGN radiation field., Comment: Accepted for publication in MNRAS, 19 pages, 13 figures
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- 2014
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31. Poor peripheral binding depends in part on stimulus color
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Gunther, Karen L. and McKinney, Mason R.
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- 2020
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32. PKMζ, But Not PKCλ, Is Rapidly Synthesized and Degraded at the Neuronal Synapse
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Palida, Sakina F, Butko, Margaret T, Ngo, John T, Mackey, Mason R, Gross, Larry A, Ellisman, Mark H, and Tsien, Roger Y
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Biomedical and Clinical Sciences ,Neurosciences ,Neurological ,Amino Acid Sequence ,Animals ,Cells ,Cultured ,Dendritic Spines ,Enzyme Stability ,HEK293 Cells ,Humans ,Isoenzymes ,Long-Term Potentiation ,Molecular Sequence Data ,Protein Kinase C ,Proteolysis ,Rats ,Rats ,Sprague-Dawley ,Synapses ,Up-Regulation ,long-term potentiation ,memory ,protein kinases ,protein synthesis ,protein turnover ,synaptic plasticity ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
Synthesizing, localizing, and stabilizing new protein copies at synapses are crucial factors in maintaining the synaptic changes required for storing long-term memories. PKMζ recently emerged as a molecule putatively responsible for maintaining encoded memories over time because its presence correlates with late LTP and because its inhibition disrupts LTP in vitro and long-term memory storage in vivo. Here we investigated PKMζ stability in rat neurons to better understand its role during information encoding and storage. We used TimeSTAMP reporters to track the synthesis and degradation of PKMζ as well as a related atypical PKC, PKCλ. These reporters revealed that both PKMζ and PKCλ were upregulated after chemical LTP induction; however, these new PKMζ copies exhibited more rapid turnover than basally produced PKMζ, particularly in dendritic spines. In contrast to PKMζ, new PKCλ copies exhibited elevated stability. Stable information storage over long periods of time is more challenging the shorter the metabolic lifetime of the candidate molecules.
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- 2015
33. Uncovering the deeply embedded AGN activity in the nuclear regions of the interacting galaxy Arp299
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Alonso-Herrero, A., Roche, P. F., Esquej, P., Gonzalez-Martin, O., Pereira-Santaella, M., Almeida, C. Ramos, Levenson, N. A., Packham, C., Ramos, A. Asensio, Mason, R. E., Espinosa, J. M. Rodriguez, Alvarez, C., Colina, L., Aretxaga, I., Diaz-Santos, T., Perlman, E., and Telesco, C. M.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present mid-infrared (MIR) 8-13micron spectroscopy of the nuclear regions of the interacting galaxy Arp299 (IC694+NGC3690) obtained with CanariCam (CC) on the 10.4m Gran Telescopio Canarias (GTC). The high angular resolution (~0.3-0.6arcsec) of the data allows us to probe nuclear physical scales between 60 and 120pc, which is a factor of 10 improvement over previous MIR spectroscopic observations of this system. The GTC/CC spectroscopy displays evidence of deeply embedded Active Galactic Nucleus (AGN) activity in both nuclei. The GTC/CC nuclear spectrum of NGC3690/Arp299-B1 can be explained as emission from AGN-heated dust in a clumpy torus with both a high covering factor and high extinction along the line of sight. The estimated bolometric luminosity of the AGN in NGC3690 is 3.2(+/-0.6)x10^44 erg/s. The nuclear GTC/CC spectrum of IC694/Arp299-A shows 11.3micron polycyclic aromatic hydrocarbon (PAH) emission stemming from a deeply embedded (A_V~24mag) region of less than 120pc in size. There is also a continuum-emitting dust component. If associated with th putative AGN in IC694, we estimate that it would be approximately 5 times less luminous than the AGN in NGC3690. The presence of dual AGN activity makes Arp299 a good example to study such phenomenon in the early coalescence phase of interacting galaxies., Comment: Accepted for publication in ApJ Letters
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- 2013
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34. Nuclear star formation activity and black hole accretion in nearby Seyfert galaxies
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Esquej, P., Alonso-Herrero, A., González-Martín, O., Hönig, S. F., Caballero, A. Hernán, Roche, P. F., Almeida, C. Ramos, Mason, R. E., Díaz-Santos, T., Levenson, N. A., Aretxaga, I., Espinosa, J. M. Rodríguez, and Packham, C.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Recent theoretical and observational works indicate the presence of a correlation between the star formation rate (SFR) and the active galactic nuclei (AGN) luminosity (and, therefore, the black hole accretion rate) of Seyfert galaxies. This suggests a physical connection between the gas forming stars on kpc scales and the gas on sub-pc scales that is feeding the black hole. We compiled the largest sample of Seyfert galaxies to date with high angular resolution (0.4-0.8 arcsec) mid-infrared (8-13 micron) spectroscopy. The sample includes 29 Seyfert galaxies drawn from the AGN Revised Shapley-Ames catalogue. At a median distance of 33 Mpc, our data allow us to probe nuclear regions on scales of 65 pc (median value). We found no general evidence of suppression of the 11.3 micron polycyclic aromatic hydrocarbon (PAH) emission in the vicinity of these AGN, and used this feature as a proxy for the SFR. We detected the 11.3 micron PAH feature in the nuclear spectra of 45% of our sample. The derived nuclear SFRs are, on average, five times lower than those measured in circumnuclear regions of 600 pc in size (median value). However, the projected nuclear SFR densities are a factor of 20 higher than those measured on circumnuclear scales. This indicates that the SF activity per unit area in the central 65 pc of Seyfert galaxies is much higher than at larger distances from their nuclei. We studied the connection between the nuclear SFR and the black hole accretion rate and showed that numerical simulations reproduce fairly well our observed relation., Comment: 16 pages, 8 figures. Accepted for publication in ApJ
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- 2013
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35. The role of the accretion disk, dust, and jets in the IR emission of low-luminosity AGN
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Mason, R. E., Almeida, C. Ramos, Levenson, N. A., Nemmen, R., and Alonso-Herrero, A.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We use recent high-resolution infrared (IR; 1 - 20 micron) photometry to examine the origin of the IR emission in low-luminosity active galactic nuclei (LLAGN). The data are compared with published model fits that describe the spectral energy distribution of LLAGN in terms of an advection-dominated accretion flow (ADAF), truncated thin accretion disk, and jet. The truncated disk in these models is usually not luminous enough to explain the observed IR emission, and in all cases its spectral shape is much narrower than the broad IR peaks in the data. Synchrotron radiation from the jet appears to be important in very radio-loud nuclei, but the detection of strong silicate emission features in many objects indicates that dust must also contribute. We investigate this point by fitting the IR SED of NGC 3998 using dusty torus and optically thin (tau_MIR ~ 1) dust shell models. While more detailed modeling is necessary, these initial results suggest that dust may account for the nuclear mid-IR emission of many LLAGN., Comment: ApJ, accepted; 6 pages, 4 figures
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- 2013
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36. Understanding the impact of COVID-19 on youth sport in Australia and consequences for future participation and retention
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Elliott, Sam, Drummond, M. J., Prichard, I., Eime, R., Drummond, C., and Mason, R.
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- 2021
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37. Time-resolved relaxation and fragmentation of polycyclic aromatic hydrocarbons investigated in the ultrafast XUV-IR regime
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Lee, J. W. L., Tikhonov, D. S., Chopra, P., Maclot, S., Steber, A. L., Gruet, S., Allum, F., Boll, R., Cheng, X., Düsterer, S., Erk, B., Garg, D., He, L., Heathcote, D., Johny, M., Kazemi, M. M., Köckert, H., Lahl, J., Lemmens, A. K., Loru, D., Mason, R., Müller, E., Mullins, T., Olshin, P., Passow, C., Peschel, J., Ramm, D., Rompotis, D., Schirmel, N., Trippel, S., Wiese, J., Ziaee, F., Bari, S., Burt, M., Küpper, J., Rijs, A. M., Rolles, D., Techert, S., Eng-Johnsson, P., Brouard, M., Vallance, C., Manschwetus, B., and Schnell, M.
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- 2021
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38. Shades of grey: host phenotype dependent effect of urbanization on the bacterial microbiome of a wild mammal
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Stothart, Mason R. and Newman, Amy E. M.
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- 2021
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39. Estimations of the magnetic field strength in the torus of AGN using near-infrared polarimetry
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Lopez-Rodriguez, E., Packham, C., Young, S., Elitzur, M., Levenson, N. A., Mason, R. E., Almeida, C. Ramos, Alonso-Herrero, A., Jones, T. J., and Perlman, E.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
An optically and geometrically thick torus obscures the central engine of Active Galactic Nuclei (AGN) from some lines of sight. From a magnetohydrodynamical framework, the torus can be considered to be a particular region of clouds surrounding the central engine where the clouds are dusty and optically thick. In this framework, the magnetic field plays an important role in the creation, morphology and evolution of the torus. If the dust grains within the clouds are assumed to be aligned by paramagnetic alignment, then the ratio of the intrinsic polarisation and visual extinction, P(%)/Av, is a function of the magnetic field strength. To estimate the visual extinction through the torus and constrain the polarisation mechanisms in the nucleus of AGN, we developed a polarisation model to fit both the total and polarised flux in a 1.2" (~263pc) aperture of the type 2 AGN, IC5063. The polarisation model is consistent with the nuclear polarisation observed at K being produced by dichroic absorption from aligned dust grains with a visual extinction through the torus of 48$\pm$2 mag. We estimated the intrinsic polarisation arising from dichroic absorption to be P$_{K}^{dic}$=12.5$\pm$2.7%. We consider the physical conditions and environment of the gas and dust for the torus of IC5063. Then, through paramagnetic alignment, we estimate a magnetic field strength in the range of 12-128mG in the NIR emitting regions of the torus of IC5063. Alternatively, we estimate the magnetic field strength in the plane of the sky using the Chandrasekhar-Fermi method. The minimum magnetic field strength in the plane of the sky is estimated to be 13 and 41 mG depending of the conditions within the torus of IC5063. These techniques afford the chance to make a survey of AGN, to investigate the effects of magnetic field strength on the torus, accretion, and interaction to the host galaxy., Comment: Accepted by MNRAS, 16 pages, 10 figures, 6 tables
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- 2013
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40. Dust in active galactic nuclei. Mid-infrared T-ReCS/Gemini spectra using the new RedCan pipeline
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Gonzalez-Martin, O., Rodriguez-Espinosa, J. M., Diaz-Santos, T., Packham, C., Alonso-Herrero, A., Esquej, P., Almeida, C. Ramos, Mason, R., and Telesco, C.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The unified model of active galactic nuclei (AGN) claims that the properties of AGN depend on the viewing angle of the observer with respect to a toroidal distribution of dust surrounding the nucleus. Both the mid-infrared (MIR) attenuation and continuum luminosity are expected to be related to dust associated with the torus. Therefore, isolating the nuclear component is essential to study the MIR emission of AGN. We have compiled all the T-ReCS spectra (Gemini observatory) available in the N-band for 22 AGN: 5 Type-1 and 17 Type-2 AGN. The high angular resolution of the T-ReCs spectra allows us to probe physical regions of 57 pc (median). We have used a novel pipeline called RedCan capable of producing flux- and wavelength-calibrated spectra for the CanariCam (GTC) and T-ReCS (Gemini) instruments. We have measured the fine-structure [SIV] at 10.5 microns and the PAH at 11.3 microns line strengths together with the silicate absorption/emission features. We have also compiled Spitzer/IRS spectra to understand how spatial resolution influences the results. The 11.3 microns PAH feature is only clearly detected in the nuclear spectra of two AGN, while it is more common in the Spitzer data. For those two objects the AGN emission in NGC7130 accounts for more than 80% of the MIR continuum at 12 microns while in the case of NGC1808 the AGN is not dominating the MIR emission. This is confirmed by the correlation between the MIR and X-ray continuum luminosities. The [SIV] emission line at 10.5 microns, which is believed to originate in the narrow line region, is detected in most AGN. We have found an enhancement of the optical depth at 9.7 microns in the high-angular resolution data for higher values of NH. Clumpy torus models reproduce the observed values only if the host-galaxy properties are taken into account., Comment: 8 figures, 16 pages, accepted for publication in A&A
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- 2012
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41. The Nuclear Infrared Emission of Low-Luminosity Active Galactic Nuclei
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Mason, R. E., Lopez-Rodriguez, E., Packham, C., Alonso-Herrero, A., Levenson, N. A., Radomski, J., Almeida, C. Ramos, Colina, L., Elitzur, M., Aretxaga, I., Roche, P. F., and Oi, N.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present high-resolution mid-infrared (MIR) imaging, nuclear spectral energy distributions (SEDs) and archival Spitzer spectra for 22 low-luminosity active galactic nuclei (LLAGN; Lbol \lesssim 10^42 erg/sec). Infrared (IR) observations may advance our understanding of the accretion flows in LLAGN, the fate of the obscuring torus at low accretion rates, and, perhaps, the star formation histories of these objects. However, while comprehensively studied in higher-luminosity Seyferts and quasars, the nuclear IR properties of LLAGN have not yet been well-determined. We separate the present LLAGN sample into three categories depending on their Eddington ratio and radio emission, finding different IR characteristics for each class. (I) At the low-luminosity, low-Eddington ratio (log Lbol/LEdd < -4.6) end of the sample, we identify "host-dominated" galaxies with strong polycyclic aromatic hydrocarbon bands that may indicate active (circum-)nuclear star formation. (II) Some very radio-loud objects are also present at these low Eddington ratios. The IR emission in these nuclei is dominated by synchrotron radiation, and some are likely to be unobscured type 2 AGN that genuinely lack a broad line region. (III) At higher Eddington ratios, strong, compact nuclear sources are visible in the MIR images. The nuclear SEDs of these galaxies are diverse; some resemble typical Seyfert nuclei, while others lack a well-defined MIR "dust bump". Strong silicate emission is present in many of these objects. We speculate that this, together with high ratios of silicate strength to hydrogen column density, could suggest optically thin dust and low dust-to-gas ratios, in accordance with model predictions that LLAGN do not host a Seyfert-like obscuring torus., Comment: Accepted for publication in AJ
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- 2012
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42. Testing the AGN Unification Model in the Infrared
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Almeida, Cristina Ramos, Levenson, N. A., Alonso-Herrero, A., Ramos, A. Asensio, Espinosa, J. M. Rodriguez, Garcia, A. M. Perez, Packham, C., Mason, R., Radomski, J. T., and Diaz-Santos, T.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present near-to-mid-infrared spectral energy distributions (SEDs) for 21 Seyfert galaxies, using subarcsecond resolution imaging data. Our aim is to compare the properties Seyfert 1 (Sy1) and Seyfert 2 (Sy2) tori using clumpy torus models and a Bayesian approach to fit the infrared (IR) nuclear SEDs. These dusty tori have physical sizes smaller than 6 pc radius, as derived from our fits. Active galactic nuclei (AGN) unification schemes account for a variety of observational differences in terms of viewing geometry. However, we find evidence that strong unification may not hold, and that the immediate dusty surroundings of Sy1 and Sy2 nuclei are intrinsically different. The Type 2 tori studied here are broader, have more clumps, and these clumps have lower optical depths than those of Type 1 tori. The larger the covering factor of the torus, the smaller the probability of having direct view of the AGN, and vice-versa. In our sample, Sy2 tori have larger covering factors (C_T=0.95+/-0.02) and smaller escape probabilities than those of Sy1 (C_T=0.5+/-0.1). Thus, on the basis of the results presented here, the classification of a Seyfert galaxy may depend more on the intrinsic properties of the torus rather than on its mere inclination, in contradiction with the simplest unification model., Comment: 8 pages, 5 figures. To appear in the proceedings of the conference "The central kiloparsec in Galactic Nuclei"
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- 2012
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43. The Nuclear Infrared Emission of Low-Luminosity AGN
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Mason, R E, Lopez-Rodriguez, E, Packham, C, Alonso-Herrero, A, Levenson, N A, Radomski, J, Almeida, C Ramos, Colina, L, Elitzur, M, Aretxaga, I, Roche, P F, and Oi, N
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We have obtained high-resolution mid-infrared (MIR) imaging, nuclear spectral energy distributions (SEDs) and archival Spitzer spectra for 22 low-luminosity active galactic nuclei (LLAGN; L_bol < 5 x 10^42 erg/s). Infrared (IR) observations may advance our understanding of the accretion flows in LLAGN, the fate of the obscuring torus at low accretion rates, and, perhaps, the star formation histories of these objects. However, while comprehensively studied in higher-luminosity Seyferts and quasars, the nuclear IR properties of LLAGN have not yet been well-determined. In these proceedings we summarise the results for the LLAGN at the relatively high-luminosity, high-Eddington ratio end of the sample. Strong, compact nuclear sources are visible in the MIR images of these objects, with luminosities consistent with or slightly in execss of that predicted by the standard MIR/X-ray relation. Their broadband nuclear SEDs are diverse; some resemble typical Seyfert nuclei, while others possess less of a well-defined MIR ``dust bump''. Strong silicate emission is present in many of these objects. We speculate that this, together with high ratios of silicate strength to hydrogen column density, could suggest optically thin dust and low dust-to-gas ratios, in accordance with model predictions that LLAGN do not host a Seyfert-like obscuring torus., Comment: 8 pages, 4 figures, to appear in "The Central Kiloparsec in Galactic Nuclei: Astronomy at High Angular Resolution 2011", open access Journal of Physics: Conference Series (JPCS), published by IOP Publishing
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- 2012
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44. Constraining GRB Emission Physics with Extensive Early-Time, Multiband Follow-up
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Cucchiara, A., Cenko, S. B., Bloom, J. S., Melandri, A., Morgan, A., Kobayashi, S., Smith, R. J., Perley, D. A., Li, W., Hora, J. L., da Silva, R. L., Prochaska, J. X., Milne, P. A., Butler, N. R., Cobb, B., Worseck, G., Mundell, C. G., Steele, I. A., Filippenko, A. V., Fumagalli, M., Klein, C. R., Stephens, A., Bluck, A., and Mason, R.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Understanding the origin and diversity of emission processes responsible for Gamma-ray Bursts (GRBs) remains a pressing challenge. While prompt and contemporaneous panchromatic observations have the potential to test predictions of the internal-external shock model, extensive multiband imaging has been conducted for only a few GRBs. We present rich, early-time, multiband datasets for two \swift\ events, GRB 110205A and GRB 110213A. The former shows optical emission since the early stages of the prompt phase, followed by the steep rising in flux up to ~1000s after the burst ($t^{-\alpha}$ with $\alpha=-6.13 \pm 0.75$). We discuss this feature in the context of the reverse-shock scenario and interpret the following single power-law decay as being forward-shock dominated. Polarization measurements, obtained with the RINGO2 instrument mounted on the Liverpool Telescope, also provide hints on the nature of the emitting ejecta. The latter event, instead, displays a very peculiar optical to near-infrared lightcurve, with two achromatic peaks. In this case, while the first peak is probably due to the onset of the afterglow, we interpret the second peak to be produced by newly injected material, signifying a late-time activity of the central engine., Comment: 48 pages,11 figures, 24 tables. Accepted to The Astrophysical Journal
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- 2011
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45. The Magnetic Structure of $Er_{2}Ti_{2}O_{7}$
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Briffa, A. K. R., Mason, R. J., and Long, M. W.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Other Condensed Matter - Abstract
We employ the previously published neutron scattering experiments\cite{1,2,3} to suggest that Er$_2$Ti$_2$O$_7$ has a broken-symmetry multiple-{\bf q} state with tetragonal magnetic symmetry\cite{4}. The ordered moments do not appear to lie close to the crystal-field anticipated directions\cite{5} and we suggest that the low energy gapless mode, visible in specific-heat measurements\cite{6}, is not of the usual transverse isotropic Goldstone-mode type, but is longitudinal and is associated with the internal transfer of magnetism between distinct magnetic Bragg spots., Comment: 10 pages, 5 figures
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- 2011
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46. Ices in the Quiescent IC 5146 Dense Cloud
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Chiar, J. E., Pendleton, Y. J., Allamandola, L. J., Boogert, A. C. A., Ennico, K., Greene, T. P., Geballe, T. R., Keane, J. V., Lada, C. J., Mason, R. E., Roellig, T. L., Sandford, S. A., Tielens, A. G. G. M., Werner, M. W., Whittet, D. C. B., Decin, L., and Eriksson, K.
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Astrophysics - Astrophysics of Galaxies - Abstract
This paper presents spectra in the 2 to 20 micron range of quiescent cloud material located in the IC 5146 cloud complex. The spectra were obtained with NASA's Infrared Telescope Facility (IRTF) SpeX instrument and the Spitzer Space Telescope's Infrared Spectrometer. We use these spectra to investigate dust and ice absorption features in pristine regions of the cloud that are unaltered by embedded stars. We find that the H2O-ice threshold extinction is 4.03+/-0.05 mag. Once foreground extinction is taken into account, however, the threshold drops to 3.2 mag, equivalent to that found for the Taurus dark cloud, generally assumed to be the touchstone quiescent cloud against which all other dense cloud and embedded young stellar object observations are compared. Substructure in the trough of the silicate band for two sources is attributed to CH3OH and NH3 in the ices, present at the ~2% and ~5% levels, respectively, relative to H2O-ice. The correlation of the silicate feature with the E(J-K) color excess is found to follow a much shallower slope relative to lines of sight that probe diffuse clouds, supporting the previous results by Chiar et al. (2007)., Comment: 13 pages, 13 figures with multiple parts, accepted for publication in Astrophysical Journal, Feb. 2011
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- 2011
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47. Testing the Unification Model for AGN in the Infrared: are the obscuring tori of Type 1 and 2 Seyferts different?
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Almeida, C. Ramos, Levenson, N. A., Alonso-Herrero, A., Ramos, A. Asensio, Espinosa, J. M. Rodriguez, Garcia, A. M. Perez, Packham, C., Mason, R., Radomski, J. T., and Diaz-Santos, T.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present new mid-infrared (MIR) imaging data for three Type-1 Seyfert galaxies obtained with T-ReCS on the Gemini-South Telescope at subarcsecond resolution. Our aim is to enlarge the sample studied in a previous work to compare the properties of Type-1 and Type-2 Seyfert tori using clumpy torus models and a Bayesian approach to fit the infrared nuclear spectral energy distributions (SEDs). Thus, the sample considered here comprises 7 Type-1, 11 Type-2, and 3 intermediate-type Seyferts. The unresolved IR emission of the Seyfert 1 galaxies can be reproduced by a combination of dust heated by the central engine and direct AGN emission, while for the Seyfert 2 nuclei only dust emission is considered. These dusty tori have physical sizes smaller than 6 pc radius, as derived from our fits. Unification schemes of AGN account for a variety of observational differences in terms of viewing geometry. However, we find evidence that strong unification may not hold, and that the immediate dusty surroundings of Type-1 and Type-2 Seyfert nuclei are intrinsically different. The Type-2 tori studied here are broader, have more clumps, and these clumps have lower optical depths than those of Type-1 tori. The larger the covering factor of the torus, the smaller the probability of having direct view of the AGN, and vice-versa. In our sample, Seyfert 2 tori have larger covering factors and smaller escape probabilities than those of Seyfert 1. All the previous differences are significant according to the Kullback-Leibler divergence. Thus, on the basis of the results presented here, the classification of a Seyfert galaxy as a Type-1 or Type-2 depends more on the intrinsic properties of the torus rather than on its mere inclination towards us, in contradiction with the simplest unification model., Comment: 21 pages, 14 figures, Appendix including supplementary figures. Accepted by ApJ
- Published
- 2011
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48. Isotropic Mid-Infrared Emission from the Central 100 pc of Active Galaxies
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Levenson, N. A., Radomski, J. T., Packham, C., Mason, R. E., Schaefer, J. J., and Telesco, C. M.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Dust reprocesses the intrinsic radiation of active galactic nuclei (AGNs) to emerge at longer wavelengths. The observed mid-infrared (MIR) luminosity depends fundamentally on the luminosity of the central engine, but in detail it also depends on the geometric distribution of the surrounding dust. To quantify this relationship, we observe nearby normal AGNs in the MIR to achieve spatial resolution better than 100 pc, and we use absorption-corrected X-ray luminosity as a proxy for the intrinsic AGN emission. We find no significant difference between optically classified Seyfert 1 and 2 galaxies. Spectroscopic differences, both at optical and IR wavelengths, indicate that the immediate surroundings of AGNs is not spherically symmetric, as in standard unified AGN models. A quantitative analysis of clumpy torus radiative transfer models shows that a clumpy local environment can account for this dependence on viewing geometry while producing MIR continuum emission that remains nearly isotropic, as we observe, although the material is not optically thin at these wavelengths. We find some luminosity dependence on the X-ray/MIR correlation in the smallest scale measurements, which may indicate enhanced dust emission associated with star formation, even on these sub-100 pc scales., Comment: 10 pages, 5 figures; accepted for publication in ApJ
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- 2009
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49. The 3-5 micron Spectrum of NGC 1068 at High Angular Resolution: Distribution of Emission and Absorption Features across the Nuclear Continuum Source
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Geballe, T. R., Mason, R. E., Rodríguez-Ardila, A., and Axon, D. J.
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Astrophysics - Cosmology and Extragalactic Astrophysics - Abstract
We report moderate resolution 3-5 micron spectroscopy of the nucleus of NGC 1068 obtained at 0.3 arcsec (20 pc) resolution with the spectrograph slit aligned approximately along the ionization cones of the AGN. The deconvolved FWHM of the nuclear continuum source in this direction is 0.3 arcsec. Four coronal lines of widely different excitations were detected; the intensity of each peaks near radio knot C, approximately 0.3 arcsec north of the infrared continuum peak, where the radio jet changes direction. Together with the broadened line profiles observed near that location, this suggests that shock-ionization is the dominant excitation mechanism of the coronal lines. The depth of the 3.4 micron hydrocarbon absorption is maximum at and just south of the continuum peak, similar to the 10 micron silicate absorption. That and the similar and rapid variations of the optical depths of both features across the nucleus suggest that substantial portions of both arise in a dusty environment just in front of the continuum source(s). A new and tighter limit is set on the column density of CO. Although clumpy models of the dust screen might explain the shallowness of the silicate feature, the presence of the 3.4 micron feature and the absence of CO are strongly reminiscent of Galactic diffuse cloud environments and a consistent explanation for them and the observed silicate feature is found if all three phenomena occur in such an environment, existing as close as 10 pc from the central engine., Comment: 42 pages, incl. 2 tables and 5 figures. Accepted by ApJ on 22 June 2009. Typos fixed, references changed/removed
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- 2009
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50. The Origin of the Silicate Emission Features in the Seyfert 2 Galaxy, NGC 2110
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Mason, R. E., Levenson, N. A., Shi, Y., Packham, C., Gorjian, V., Cleary, K., Rhee, J., and Werner, M.
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Astrophysics - Galaxy Astrophysics - Abstract
The unified model of active galactic nuclei (AGN) predicts silicate emission features at 10 and 18 microns in type 1 AGN, and such features have now been observed in objects ranging from distant QSOs to nearby LINERs. More surprising, however, is the detection of silicate emission in a few type 2 AGN. By combining Gemini and Spitzer mid-infrared imaging and spectroscopy of NGC 2110, the closest known Seyfert 2 galaxy with silicate emission features, we can constrain the location of the silicate emitting region to within 32 pc of the nucleus. This is the strongest constraint yet on the size of the silicate emitting region in a Seyfert galaxy of any type. While this result is consistent with a narrow line region origin for the emission, comparison with clumpy torus models demonstrates that emission from an edge-on torus can also explain the silicate emission features and 2-20 micron spectral energy distribution of this object. In many of the best-fitting models the torus has only a small number of clouds along the line of sight, and does not extend far above the equatorial plane. Extended silicate-emitting regions may well be present in AGN, but this work establishes that emission from the torus itself is also a viable option for the origin of silicate emission features in active galaxies of both type 1 and type 2., Comment: ApJL, accepted
- Published
- 2009
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