12 results on '"Mason, Philip H."'
Search Results
2. A Genomic Score Prognostic of Outcome in Trauma Patients
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Warren, H. Shaw, Elson, Constance M., Hayden, Douglas L., Schoenfeld, David A., Cobb, J. Perren, Maier, Ronald V., Moldawer, Lyle L., Moore, Ernest E., Harbrecht, Brian G., Pelak, Kimberly, Cuschieri, Joseph, Herndon, David N., Jeschke, Marc G., Finnerty, Celeste C., Brownstein, Bernard H., Hennessy, Laura, Mason, Philip H., Tompkins, Ronald G., and The Inflammation and the Host Response to Injury Large Scale Collaborative Research Program
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- 2009
- Full Text
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3. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways
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Laudanski, Krzysztof, Miller-Graziano, Carol, Xiao, Wenzhong, Mindrinos, Michael N., Richards, Daniel R., De, Asit, Moldawer, Lyle L., Maier, Ronald V., Bankey, Paul, Baker, Henry V., Brownstein, Bernard H., Cobb, J. Perren, Calvano, Steve E., Davis, Ronald W., Tompkins, Ronald G., Billiar, Timothy R., Camp, David, II, Campbell-Finnerty, Celeste, Casella, George, Chaudry, Irshad H., Choudhry, Mashkoor, Elson, Constance, Freeman, Bradley, Gamelli, Richard L., Gibran, Nicole S., Harbrecht, Brian G., Hayden, Douglas L., Herndon, David N., Horton, Jureta W., Hubbard, William, Hunt, John Lee, Johnson, Jeffrey, Klein, Matthew B., Lederer, James A., Logvinenko, Tanya, Lowry, Stephen F., Mannick, John A., Mason, Philip H., McDonald-Smith, Grace P., McKinley, Bruce A., Minei, Joseph P., Moore, Ernest E., Moore, Frederick A., Nathens, Avery B., O'Keefe, Grant E., Rahme, Laurence G., Remick, Daniel G., Jr., Schoenfeld, David A., Shapiro, Michael B., Schwacha, Martin, Silver, Geoffrey M., Smith, Richard D., Storey, John, Toner, Mehmet, Warren, H. Shaw, and West, Michael A.
- Subjects
T cells -- Research ,Immunosuppression -- Research ,Monocytes -- Research ,Science and technology - Abstract
Monitoring genome-wide, cell-specific responses to human disease, although challenging, holds great promise for the future of medicine. Patients with injuries severe enough to develop multiple organ dysfunction syndrome have multiple immune derangements, including T cell apoptosis and anergy combined with depressed monocyte antigen presentation. Genome-wide expression analysis of highly enriched circulating leukocyte subpopulations, combined with cell-specific pathway analyses, offers an opportunity to discover leukocyte regulatory networks in critically injured patients. Severe injury induced significant changes in T cell (5,693 genes), monocyte (2,801 genes), and total leukocyte (3,437 genes) transcriptomes, with only 911 of these genes common to all three cell populations (12%). T cell-specific pathway analyses identified increased gene expression of several inhibitory receptors (PD-1, CD152, NRP-1, and Lag3) and concomitant decreases in stimulatory receptors (CD28, CD4, and IL-2R[alpha]). Functional analysis of T cells and monocytes confirmed reduced T cell proliferation and increased cell surface expression of negative signaling receptors paired with decreased monocyte costimulation ligands. Thus, genome-wide expression from highly enriched cell populations combined with knowledge-based pathway analyses leads to the identification of regulatory networks differentially expressed in injured patients. Importantly, application of cell separation, genome-wide expression, and cell-specific pathway analyses can be used to discover pathway alterations in human disease. anergy | apoptosis | costimulatory receptors | immunosuppression | network analysis
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- 2006
4. Benchmarking Outcomes in the Critically Injured Burn Patient
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Klein, Matthew B., primary, Goverman, Jeremy, additional, Hayden, Douglas L., additional, Fagan, Shawn P., additional, McDonald-Smith, Grace P., additional, Alexander, Andrew K., additional, Gamelli, Richard L., additional, Gibran, Nicole S., additional, Finnerty, Celeste C., additional, Jeschke, Marc G., additional, Arnoldo, Brett, additional, Wispelwey, Bram, additional, Mindrinos, Michael N., additional, Xiao, Wenzhong, additional, Honari, Shari E., additional, Mason, Philip H., additional, Schoenfeld, David A., additional, Herndon, David N., additional, and Tompkins, Ronald G., additional
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- 2014
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5. Benchmarking Outcomes in the Critically Injured Trauma Patient and the Effect of Implementing Standard Operating Procedures
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Cuschieri, Joseph, primary, Johnson, Jeffrey L., additional, Sperry, Jason, additional, West, Michael A., additional, Moore, Ernest E., additional, Minei, Joseph P., additional, Bankey, Paul E., additional, Nathens, Avery B., additional, Cuenca, Alex G., additional, Efron, Philip A., additional, Hennessy, Laura, additional, Xiao, Wenzhong, additional, Mindrinos, Michael N., additional, McDonald-Smith, Grace P., additional, Mason, Philip H., additional, Billiar, Timothy R., additional, Schoenfeld, David A., additional, Warren, H. Shaw, additional, Cobb, J. Perren, additional, Moldawer, Lyle L., additional, Davis, Ronald W., additional, Maier, Ronald V., additional, and Tompkins, Ronald G., additional
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- 2012
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6. A genomic storm in critically injured humans
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Xiao, Wenzhong, primary, Mindrinos, Michael N., additional, Seok, Junhee, additional, Cuschieri, Joseph, additional, Cuenca, Alex G., additional, Gao, Hong, additional, Hayden, Douglas L., additional, Hennessy, Laura, additional, Moore, Ernest E., additional, Minei, Joseph P., additional, Bankey, Paul E., additional, Johnson, Jeffrey L., additional, Sperry, Jason, additional, Nathens, Avery B., additional, Billiar, Timothy R., additional, West, Michael A., additional, Brownstein, Bernard H., additional, Mason, Philip H., additional, Baker, Henry V., additional, Finnerty, Celeste C., additional, Jeschke, Marc G., additional, López, M. Cecilia, additional, Klein, Matthew B., additional, Gamelli, Richard L., additional, Gibran, Nicole S., additional, Arnoldo, Brett, additional, Xu, Weihong, additional, Zhang, Yuping, additional, Calvano, Steven E., additional, McDonald-Smith, Grace P., additional, Schoenfeld, David A., additional, Storey, John D., additional, Cobb, J. Perren, additional, Warren, H. Shaw, additional, Moldawer, Lyle L., additional, Herndon, David N., additional, Lowry, Stephen F., additional, Maier, Ronald V., additional, Davis, Ronald W., additional, and Tompkins, Ronald G., additional
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- 2011
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7. Validation of the Riboleukogram to Detect Ventilator-Associated Pneumonia After Severe Injury
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Cobb, J Perren, primary, Moore, Ernest E., additional, Hayden, Doug L., additional, Minei, Joseph P., additional, Cuschieri, Joseph, additional, Yang, Jingyun, additional, Li, Qing, additional, Lin, Nan, additional, Brownstein, Bernard H., additional, Hennessy, Laura, additional, Mason, Philip H., additional, Schierding, William S., additional, Dixon, David J., additional, Tompkins, Ronald G., additional, Warren, H Shaw, additional, Schoenfeld, David A., additional, and Maier, Ronald V., additional
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- 2009
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8. Corrigendum: A network-based analysis of systemic inflammation in humans
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Calvano, Steve E., Xiao, Wenzhong, Richards, Daniel R., Felciano, Ramon M., Baker, Henry V., Cho, Raymond J., Chen, Richard O., Brownstein, Bernard H., Cobb, J. Perren, Tschoeke, S. Kevin, Miller-Graziano, Carol, Moldawer, Lyle L., Mindrinos, Michael N., Davis, Ronald W., Tompkins, Ronald G., Lowry, Stephen F., Bankey, Paul E., Billiar, Timothy R., Camp, David G., Casella, George, Chaudry, Irshad H., Choudhry, Mashkoor A., Cooper, Charles, De, Asit, Elson, Constance, Freeman, Bradley, Gamelli, Richard L., Campbell-Finnerty, Celeste, Gibran, Nicole S., Hayden, Douglas L., Harbrecht, Brian G., Herndon, David N., Horton, Jureta W., Hubbard, William J., Hunt, John L., Johnson, Jeffrey, Klein, Matthew B., Lederer, James A., Logvinenko, Tanya, Maier, Ronald V., Mannick, John A., Mason, Philip H., McKinley, Bruce A., Minei, Joseph P., Moore, Ernest E., Moore, Frederick A., Nathens, Avery B., O'Keefe, Grant E., Rahme, Laurence G., Remick, Daniel G., Schoenfeld, David A., Schwacha, Martin G., Shapiro, Michael B., Silver, Geoffrey M., Smith, Richard D., Storey, John D., Toner, Mehmet, Warren, H. Shaw, and West, Michael A.
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Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Author(s): Steve E. Calvano; Wenzhong Xiao; Daniel R. Richards; Ramon M. Felciano; Henry V. Baker; Raymond J. Cho; Richard O. Chen; Bernard H. Brownstein; J. Perren Cobb; S. Kevin Tschoeke; [...]
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- 2005
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9. The promoter's purse
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Mason, Philip H. and Mfume, Kweisi
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National Association for the Advancement of Colored People -- Ethical aspects ,Sports promoters -- Ethical aspects ,African American leadership -- Ethical aspects - Published
- 1997
10. A Genomic Storm in Critically Injured Humans
- Author
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Mindrinos, Michael N., Seok, Junhee, Cuschieri, Joseph, Cuenca, Alex G., Hayden, Douglas L., Hennessy, Laura, Moore, Ernest E., Minei, Joseph P., Bankey, Paul E., Sperry, Jason, Nathens, Avery B., Billiar, Timothy R., Brownstein, Bernard H., Mason, Philip H., Baker, Henry V., Finnerty, Celeste C., Jeschke, Marc G., López, M. Cecilia, Klein, Matthew B., Gamelli, Richard L., Gibran, Nicole S., Arnoldo, Brett, Xu, Weihong, Zhang, Yuping, Calvano, Steven E., McDonald-Smith, Grace P., Storey, John D., Moldawer, Lyle L., Herndon, David N., Lowry, Stephen F., Maier, Ronald V., Davis, Ronald W., Xiao, Wenzhong, Gao, Hong, Johnson, Jeffrey L., West, Michael A., Schoenfeld, David Alan, Cobb, Joseph Perren, Warren, H. Shaw, and Tompkins, Ronald Gary
- Abstract
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well as in healthy subjects receiving low-dose bacterial endotoxin, and show that these severe stresses produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected "genomic storm." In severe blunt trauma, the early leukocyte genomic response is consistent with simultaneously increased expression of genes involved in the systemic inflammatory, innate immune, and compensatory antiinflammatory responses, as well as in the suppression of genes involved in adaptive immunity. Furthermore, complications like nosocomial infections and organ failure are not associated with any genomic evidence of a second hit and differ only in the magnitude and duration of this genomic reprioritization. The similarities in gene expression patterns between different injuries reveal an apparently fundamental human response to severe inflammatory stress, with genomic signatures that are surprisingly far more common than different. Based on these transcriptional data, we propose a new paradigm for the human immunological response to severe injury.
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- 2011
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11. Design Tools for Evaluating Multiprocessor Programs
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CARNEGIE-MELLON UNIV PITTSBURGH PA DEPT OF COMPUTER SCIENCE, Mason, Philip H, CARNEGIE-MELLON UNIV PITTSBURGH PA DEPT OF COMPUTER SCIENCE, and Mason, Philip H
- Abstract
An approach to designing programs for implementation in a multiple instruction stream-multiple data stream processing environment is presented. A program is modeled as a directed graph consisting of two types of nodes: processing nodes and linking nodes. Communication among nodes in the model is represented by message tokens. Each processing node is similar in form to a semi-Markov process. A simulation of the operation of the model is nondeterministic, but is based on prescribed probabilistic choice functions. A system, called STEPPS, has been built in which a model can be described and evaluation tools can be used to manipulate and act upon a model to predict performance of a program decomposition. The design approach is to describe a multiprocessing program in terms of the modeling system. The model is examined to determine some analytic attributes of the model. The analysis available determines (a) whether the model is well formed, (b) whether the model contains deadlocks, (c) predictions of steady state properties of each process. In addition, without much difficulty, analysis functions external to STEPPS may be included as needed by a program designer.
- Published
- 1976
12. Satellite Data Management Algorithm Study.
- Author
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PRC INFORMATION SCIENCES CO MCLEAN VA, Larson,Arvid G., Mason,Philip H., Keiser,Bernhard E., PRC INFORMATION SCIENCES CO MCLEAN VA, Larson,Arvid G., Mason,Philip H., and Keiser,Bernhard E.
- Abstract
This report deals with one aspect of SAMSO R/D program into advanced space communications networks. It presents the results of a study to consider the design of data management algorithms to optimize performance measures and resource allocations within network and user demand constraints. Included are considerations of message distribution modes (e.g., packet switching algorithms), information control (e.g., flow control and routing algorithms) and multiple access techniques. In the context of this study, data management algorithms consist of all the rules which govern information flow within an envisioned multiple-satellite multiple-mission space communications network. Such data management algorithms permit the orderly interaction of information sources, intelligent satellite nodes which form the communication networks, and the information users. A generalized satellite-based information network model is developed. Generic characteristics of the network information processing and transmission resources are identified as the basis for an evolutionary space communications network.
- Published
- 1976
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