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The purpose of this study was to research comparative analysis of data that have been obtained after clinical examination of goats and analysis of biochemical research of the level of metabolites of bone tissue metabolism in blood serum and urine for determination of criteria at diagnostics of osteodystrophy. The material of the study consisted of 20 adult goats. Diagnosis of was made according to physical examination of goats and analysis of biochemical research of the level of metabolites of bone tissue metabolism in blood serum and urine. Activity of aminotransferase (alanine aminotransferase, aspartate aminotransferase) and alkaline phosphatase and also concentration of glycoproteins (GP), chondroitin sulfate, fractional content of glucosaminoglycans, content of total and ionized calcium were assessed in blood serum. The content of hydroxyproline and total uronic acid were analyzed in urine. Comparative analysis of total clinical status of goats and level of biochemical components in blood serum and urine that characterize the state of connective tissue at diagnostics of osteodystrophy was conducted. The intergroup significant differences of some biochemical parameters (aspartate aminotransferase, alkaline phosphatase, chondroitin sulfate, fraction II mucopolysaccharides, sum of fractions glucosaminoglycans) were determined. Further investigation must be conducted to determine the biochemical parameters in goat with subclinical signs of osteodystrophy. [ABSTRACT FROM AUTHOR]