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3. 20-Year Ferti-Irrigation of Agro-Energy Cultures with Municipal Wastewater: A Field Study

Author

Caniani, Donatella, Di Capua, Francesco, Mancini, Ignazio M., Masi, Salvatore, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Lu, Xinzheng, Series Editor, Mannina, Giorgio, editor, Cosenza, Alida, editor, and Mineo, Antonio, editor

Published
2024
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10. L‐DOPA Test in the Diagnosis of Childhood Short Stature: Evaluation of Growth Hormone Peaks Over Time.

Author

Castelli, Barbara, De Santis, Rita, Carrera, Simona, Malanima, Marco Andrea, De Masi, Salvatore, and Stagi, Stefano

Subjects
SOMATOTROPIN, SHORT stature, GROWTH of children, RECEIVER operating characteristic curves, CLASSIFICATION, PITUITARY dwarfism
Abstract

Introduction: In childhood, growth hormone (GH) deficiency (GHD) diagnosis is based on auxological assessment and biochemical provocative tests, whose reliability remains disputed. Recently, several papers have been published on standardising the duration of some tests. The aim of our study was to analyse the possible length reduction of the L‐DOPA provocative test. Methods: We retrospectively investigated the response of GH to L‐DOPA in 256 children, analysing 267 tests (some patients were retested over time for the persistence of severe auxopathy). We studied the same data considering GH peak threshold both at 8 ng/mL (Italian GHD cut‐off) and at 10 ng/mL (international cut‐off). Based on stimulation tests, patients were divided into two groups: GHD and no‐GHD short children. We described the results in the whole population and then clustering for gender and pubertal stage. We termed as index the test stopped at 90 min. Results: The GH peak after L‐DOPA mostly occurred at 60 min. The sensitivity of the index test was the highest, while the specificity was slightly higher using the 8 ng/mL threshold (specificity = 0.68; 95% CI 0.60–0.76) then using the 10 ng/mL threshold (specificity = 0.56; 95% CI 0.47–0.65) at 90 min. The two ROC curves showed moderate performance of the test at 90 min. While the negative predictive value was 100% in both tests, the positive predictive value was slightly better with 10 ng/mL cut‐off. Considering the two groups established by GHD definition and placing a GH threshold at 10 ng/mL, stopping L‐DOPA test time at 90 min would have changed the test result and subsequentially patient's classification in 3/267 of the analysed tests (1.1%), while with the Italian GH threshold value at 8 ng/mL in 7/267 of the tests (2.6%). Conclusions: Our research shows that omitting 120‐min time reduces L‐DOPA test specificity, especially with GHD cut‐off at 10 ng/mL. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Ergonomics in Hospital: Prevention of Interruptions and Safety in Drug Administration

Author

Frangioni, Gabriele, Biermann, Klaus P., Caposciutti, Barbara, De Masi, Salvatore, Di Pede, Mario, Prunecchi, Silvia, Savelli, Angela, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bagnara, Sebastiano, editor, Tartaglia, Riccardo, editor, Albolino, Sara, editor, Alexander, Thomas, editor, and Fujita, Yushi, editor

Published
2019
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25. Study of an eco‐efficient method for wastewater treatment and safe agricultural reuse: Effect of influent splitting rates on effluent quality parameters.

Author

El Moussaoui, Tawfik, Belloulid, Mohamed Oussama, El Ass, Khalid, Mandi, Laila, Wahbi, Said, Masi, Salvatore, and Ouazzani, Naaila

Subjects
EFFLUENT quality, WASTEWATER treatment, BIOCHEMICAL oxygen demand, AGRICULTURE, TOTAL suspended solids, ACTIVATED sludge process, BIOLOGICAL nutrient removal
Abstract

Copyright of Irrigation & Drainage is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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28. A registry for Dravet syndrome: The Italian experience

Author

Balestrini, Simona, Doccini, Viola, Giometto, Sabrina, Lucenteforte, Ersilia, De Masi, Salvatore, Giarola, Elisa, Brambilla, Isabella, Pieroni, Federica, Perulli, Marco, Battaglia, Domenica Immacolata, Specchio, Nicola, Ragona, Francesca, Granata, Tiziana, Pellacani, Simona, Ferrari, Annarita, Marini, Carla, Matricardi, Sara, Cesaroni, Elisabetta, Giordano, Lucio, Accorsi, Patrizia, Sciruicchio, Vittorio, Tinuper, Paolo, Messana, Tullio, Russo, Angelo, Pruna, Dario, Nosadini, Margherita, De Giorgis, Valentina, Caputo, Davide, Pellegrin, Serena, Lo Barco, Tommaso, Darra, Francesca, Dalla Bernardina, Bernardo, Guerrini, Renzo, Battaglia, Domenica (ORCID:0000-0003-0491-4021), Balestrini, Simona, Doccini, Viola, Giometto, Sabrina, Lucenteforte, Ersilia, De Masi, Salvatore, Giarola, Elisa, Brambilla, Isabella, Pieroni, Federica, Perulli, Marco, Battaglia, Domenica Immacolata, Specchio, Nicola, Ragona, Francesca, Granata, Tiziana, Pellacani, Simona, Ferrari, Annarita, Marini, Carla, Matricardi, Sara, Cesaroni, Elisabetta, Giordano, Lucio, Accorsi, Patrizia, Sciruicchio, Vittorio, Tinuper, Paolo, Messana, Tullio, Russo, Angelo, Pruna, Dario, Nosadini, Margherita, De Giorgis, Valentina, Caputo, Davide, Pellegrin, Serena, Lo Barco, Tommaso, Darra, Francesca, Dalla Bernardina, Bernardo, Guerrini, Renzo, and Battaglia, Domenica (ORCID:0000-0003-0491-4021)

Abstract

ObjectivesWe describe the Residras registry, dedicated to Dravet syndrome (DS) and to other phenotypes related to SCN1A mutations, as a paradigm of registry for rare and complex epilepsies. Our primary objectives are to present the tools and framework of the integrative platform, the main characteristics emerging from the patient cohort included in the registry, with emphasis on demographic, clinical outcome, and mortality. MethodsStandardized data of enrolled pediatric and adult patients were collected in 24 Italian expert centers and regularly updated at least on a yearly basis. Patients were prospectively enrolled, at registry starting, but historical retrospective data were also included. ResultsAt present, 281 individuals with DS and a confirmed SCN1A mutation are included. Most patients have data available on epilepsy (n = 263) and their overall neurological condition (n = 255), based on at least one follow-up update. Median age at first clinical assessment was 2 years (IQR 0-9) while at last follow-up was 11 years (IQR 5-18.5). During the 7-year activity of the registry, five patients died resulting in a mortality rate of 1.84 per 1000-person-years. When analyzing clinical changes over the first 5-year follow-up, we observed a significant difference in cognitive function (P < 0.001), an increased prevalence of behavioral disorders including attention deficit (P < 0.001), a significant worsening of language (P = 0.001), and intellectual disability (P < 0.001). SignificanceThe Residras registry represents a large collection of standardized national data for the DS population. The registry platform relies on a shareable and interoperable framework, which promotes multicenter high-quality data collection. In the future, such integrated platform may represent an invaluable asset for easing access to cohorts of patients that may benefit from clinical trials with emerging novel therapies, for drug safety monitoring, and for delineating natural history. Its

Published
2023

33. Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study

Author

Pavone, Rossana, primary, Fonte, Carla, additional, Sardi, Iacopo, additional, Caputo, Roberto, additional, Marziali, Elisa, additional, Mazzeo, Fabio, additional, Secci, Jacopo, additional, Bergamini, Alessia, additional, De Masi, Salvatore, additional, Leo, Maria Carmela, additional, Censullo, Maria Luigia, additional, and Bacci, Giacomo Maria, additional

Published
2022
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34. Seizure Outcome of Temporal Lobe Epilepsy Surgery in Adults and Children: A Systematic Review and Meta-Analysis

Author

Barba, Carmen, primary, Giometto, Sabrina, additional, Lucenteforte, Ersilia, additional, Pellacani, Simona, additional, Matta, Giulia, additional, Bettiol, Alessandra, additional, Minghetti, Sara, additional, Falorni, Lavinia, additional, Melani, Federico, additional, Di Giacomo, Gianpiero, additional, Giordano, Flavio, additional, De Masi, Salvatore, additional, and Guerrini, Renzo, additional

Published
2022
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37. Fetal programming and systemic sclerosis

Author

Donzelli, Gianpaolo, Carnesecchi, Giulia, Amador, Carolina, di Tommaso, Mariarosaria, Filippi, Luca, Caporali, Roberto, Codullo, Veronica, Riccieri, Valeria, Valesini, Guido, Gabrielli, Armando, Bagnati, Roberta, McGreevy, Kathleen S., De Masi, Salvatore, and Cerinic, Marco Matucci

Published
2015
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44. The management of pediatric severe traumatic brain injury: Italian guidelines

Author

Bussolin, L., Falconi, M., Leo, M. C., Parri, N., De Masi, Salvatore, Rosati, A., Cecchi, C., Spacca, B., Grandoni, M., Bettiol, A., Lucenteforte, E., Lubrano, R., Falsaperla, R., Melosi, F., Agostiniani, R., Mangiantini, F., Talamonti, G., Calderini, E., Mancino, Aldo, De Luca, Marianna, Conti, Giorgio, Petrini, F., Angileri, S., Baldazzi, M., Bertuetti, R., Biermann, K. P., Bigagli, E., Carai, A., Coniglio, C., Conio, A., Crescioli, M., D'Amato, L., Grassi, A., Iaccarino, C., Macchiarini, A., Magnoni, S., Masotti, A., Meneghini, L., Minardi, C., Moscatelli, A., Pedretti, Marisa, Piazza, S., Picardo, S. G., Pittalis, A., Pizzi, S., Pompucci, Angelo, Pugi, A., Rizzo, G., Sagredini, R., Silipo, R., Stoppa, F., and Tuccinardi, G.

Subjects
Adult, medicine.medical_specialty, Traumatic brain injury, MEDLINE, Guideline, Brain injuries, Pediatrics, Brain injuries, traumatic, Glasgow coma scale, Child, Humans, Italy, Brain Injuries, Traumatic, Language, 03 medical and health sciences, 0302 clinical medicine, traumatic, 030202 anesthesiology, Multidisciplinary approach, Medicine, Guideline development, business.industry, 030208 emergency & critical care medicine, medicine.disease, Quality of evidence, Anesthesiology and Pain Medicine, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Family medicine, business, Inclusion (education), Evidence synthesis
Abstract

Introduction The aim of the work was to update the "Guidelines for the Management of Severe Traumatic Brain Injury" published in 2012, to reflect the new available evidence, and develop the Italian national guideline for the management of severe pediatric head injuries to reduce variation in practice and ensure optimal care to patients. Evidence acquisition MEDLINE and EMBASE were searched from January 2009 to October 2017. Inclusion criteria were English language, pediatric populations (0-18 years) or mixed populations (pediatric/adult) with available age subgroup analyses. The guideline development process was started by the Promoting Group that composed a multidisciplinary panel of experts, with the representatives of the Scientific Societies, the independent expert specialists and a representative of the Patient Associations. The panel selected the clinical questions, discussed the evidence and formulated the text of the recommendations. The documentarists of the University of Florence oversaw the bibliographic research strategy. A group of literature reviewers evaluated the selected literature and compiled the table of evidence for each clinical question. Evidence synthesis The search strategies identified 4254 articles. We selected 3227 abstract (first screening) and, finally included 67 articles (second screening) to update the guideline. This Italian update includes 25 evidence-based recommendations and 5 research recommendations. Conclusions In recent years, progress has been made on the understanding of severe pediatric brain injury, as well as on that concerning all major traumatic pathology. This has led to a progressive improvement in the clinical outcome, although the quantity and quality of evidence remains particularly low.

Published
2021

45. Laparoscopic approach to acute abdomen from the Consensus Development Conference of the Società Italiana di Chirurgia Endoscopica e nuove tecnologie (SICE), Associazione Chirurghi Ospedalieri Italiani (ACOI), Società Italiana di Chirurgia (SIC), Società Italiana di Chirurgia d’Urgenza e del Trauma (SICUT), Società Italiana di Chirurgia nell’Ospedalità Privata (SICOP), and the European Association for Endoscopic Surgery (EAES)

Author

Agresta, Ferdinando, Ansaloni, Luca, Baiocchi, Gian Luca, Bergamini, Carlo, Campanile, Fabio Cesare, Carlucci, Michele, Cocorullo, Giafranco, Corradi, Alessio, Franzato, Boris, Lupo, Massimo, Mandalà, Vincenzo, Mirabella, Antonino, Pernazza, Graziano, Piccoli, Micaela, Staudacher, Carlo, Vettoretto, Nereo, Zago, Mauro, Lettieri, Emanuele, Levati, Anna, Pietrini, Domenico, Scaglione, Mariano, De Masi, Salvatore, De Placido, Giuseppe, Francucci, Marsilio, Rasi, Monica, Fingerhut, Abe, Uranüs, Selman, and Garattini, Silvio

Published
2012
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47. A mobile black soldier fly farm for on-site disposal of animal dairy manure.

Author

FRANCO, Antonio, SCIEUZO, Carmen, SALVIA, Rosanna, MANCINI, Ignazio M., CANIANI, Donatella, MASI, Salvatore, and FALABELLA, Patrizia

Subjects
HERMETIA illucens, BIOCONVERSION, INDUSTRIAL waste management, MANURES, ORGANIC fertilizers, LIVESTOCK farms, LARVAE
Abstract

Black soldier fly (BSF), Hermetia illucens (L.) (Diptera Stratiomyidae), is a saprophagous insect that is receiving a growing scientific and economic interest since during the larval stage it is extremely voracious and able to consume a wide range of organic materials. This ethological characteristic is particularly suitable for waste management at industrial scale. The extraordinary ability to accumulate high levels of proteins and lipids, allows the use of resulting larvae as animal feed or biodiesel production; the residue of the bioconversion process, that consists of larval frass and not converted organic matter is assimilable to organic fertilizer. The aim of this study was to evaluate the bioconversion process by black soldier fly larvae (BSFL) on fresh and mature dairy manure. A “mobile bioconversion unit” that works as a mobile breeding unit was used, allowing to carry out bioconversion tests directly on fields, in different livestock farms located on the Basilicata territory (Italy). Total larval and frass biomass, bioconversion yield, BSFL development time and substrate reduction were evaluated for each treatment. All the analysed parameters differed from the control (larvae fed in standard diet) but not between the two substrates from the zootechnical chain. Although development time significantly differed across treatments, BSF correctly grow and reduce all substrates confirming larvae can be used to bioconvert animal manure reducing the undesired effects occurring from mismanaged this kind of substrate. [ABSTRACT FROM AUTHOR]

Published
2022

48. Anti-Tumor Necrosis Factor-Alpha Withdrawal in Children With Inflammatory Bowel Disease in Endoscopic and Histologic Remission

Author

Scarallo, Luca, primary, Bolasco, Giulia, additional, Barp, Jacopo, additional, Bianconi, Martina, additional, di Paola, Monica, additional, Di Toma, Michele, additional, Naldini, Sara, additional, Paci, Monica, additional, Renzo, Sara, additional, Labriola, Flavio, additional, De Masi, Salvatore, additional, Alvisi, Patrizia, additional, and Lionetti, Paolo, additional

Published
2021
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49. L‐DOPATest in the Diagnosis of Childhood Short Stature: Evaluation of Growth Hormone Peaks Over Time

Author

Castelli, Barbara, De Santis, Rita, Carrera, Simona, Malanima, Marco Andrea, De Masi, Salvatore, and Stagi, Stefano

Abstract

In childhood, growth hormone (GH) deficiency (GHD) diagnosis is based on auxological assessment and biochemical provocative tests, whose reliability remains disputed. Recently, several papers have been published on standardising the duration of some tests. The aim of our study was to analyse the possible length reduction of the L‐DOPA provocative test. We retrospectively investigated the response of GH to L‐DOPA in 256 children, analysing 267 tests (some patients were retested over time for the persistence of severe auxopathy). We studied the same data considering GH peak threshold both at 8 ng/mL (Italian GHD cut‐off) and at 10 ng/mL (international cut‐off). Based on stimulation tests, patients were divided into two groups: GHD and no‐GHD short children. We described the results in the whole population and then clustering for gender and pubertal stage. We termed as index the test stopped at 90 min. The GH peak after L‐DOPA mostly occurred at 60 min. The sensitivity of the index test was the highest, while the specificity was slightly higher using the 8 ng/mL threshold (specificity = 0.68; 95% CI 0.60–0.76) then using the 10 ng/mL threshold (specificity = 0.56; 95% CI 0.47–0.65) at 90 min. The two ROC curves showed moderate performance of the test at 90 min. While the negative predictive value was 100% in both tests, the positive predictive value was slightly better with 10 ng/mL cut‐off. Considering the two groups established by GHD definition and placing a GH threshold at 10 ng/mL, stopping L‐DOPA test time at 90 min would have changed the test result and subsequentially patient's classification in 3/267 of the analysed tests (1.1%), while with the Italian GH threshold value at 8 ng/mL in 7/267 of the tests (2.6%). Our research shows that omitting 120‐min time reduces L‐DOPA test specificity, especially with GHD cut‐off at 10 ng/mL. In childhood growth hormone deficiency (GHD) diagnosis is based on auxological assessment and biochemical provocative tests. We analysed the L‐DOPA provocative test, evaluating GH peaks distribution over time and examining in detail the 120‐min time, to assess the possibility of length reduction. We noticed that omitting 120‐min time reduces test specificity, especially with GHD cut‐off at 10 ng/mL.

Published
2024
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50. Quantitative MRI-Based Analysis Identifies Developmental Limbic Abnormalities in PCDH19 Encephalopathy

Author

Lenge, Matteo, Marini, Carla, Canale, Edoardo, Napolitano, Antonio, De Masi, Salvatore, Trivisano, Marina, Mei, Davide, Longo, Daniela, Rossi Espagnet, Maria Camilla, Lucenteforte, Ersilia, Barba, Carmen, Specchio, Nicola, Striano, Pasquale, and Guerrini, Renzo

Subjects
Adult, Male, Adolescent, Cognitive Neuroscience, Encephalopathy, gyrification index, autism, Epileptogenesis, epilepsy, limbic formation, PCDH19 encephalopathy, White matter, Cellular and Molecular Neuroscience, Epilepsy, Young Adult, Neuroimaging, Cortex (anatomy), medicine, Limbic System, Humans, Child, Gyrification, Brain Mapping, business.industry, Infant, Entorhinal cortex, medicine.disease, Magnetic Resonance Imaging, White Matter, Protocadherins, medicine.anatomical_structure, Child, Preschool, Mutation, Female, business, Neuroscience, Spasms, Infantile
Abstract

Protocadherin-19 (PCDH19) is a calcium dependent cell-adhesion molecule involved in neuronal circuit formation with prevalent expression in the limbic structures. PCDH19-gene mutations cause a developmental encephalopathy with prominent infantile onset focal seizures, variably associated with intellectual disability and autistic features. Diagnostic neuroimaging is usually unrevealing. We used quantitative MRI to investigate the cortex and white matter in a group of 20 PCDH19-mutated patients. By a statistical comparison between quantitative features in PCDH19 brains and in a group of age and sex matched controls, we found that patients exhibited bilateral reductions of local gyrification index (lGI) in limbic cortical areas, including the parahippocampal and entorhinal cortex and the fusiform and lingual gyri, and altered diffusivity features in the underlying white matter. In patients with an earlier onset of seizures, worse psychiatric manifestations and cognitive impairment, reductions of lGI and diffusivity abnormalities in the limbic areas were more pronounced. Developmental abnormalities involving the limbic structures likely represent a measurable anatomic counterpart of the reduced contribution of the PCDH19 protein to local cortical folding and white matter organization and are functionally reflected in the phenotypic features involving cognitive and communicative skills as well as local epileptogenesis.

Published
2020

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