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5. Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty

Author

Mohyuddin, Hira, primary, Laffon, Blanca, additional, Teixeira, João P, additional, Costa, Solange, additional, Teixeira-Gomes, Armanda, additional, Pásaro, Eduardo, additional, Constantine, Niel, additional, Dagdag, Aline, additional, Ortmeyer, Heidi K, additional, Tizenberg, Boris, additional, Afram, Liubov, additional, Yen, Poyu, additional, Marano, Christopher, additional, Lowry, Christopher A, additional, Hoisington, Andrew J, additional, RachBeisel, Jill A, additional, Valdiglesias, Vanessa, additional, Lema-Arranz, Carlota, additional, Fernández-Bertólez, Natalia, additional, Maseda, Ana, additional, Millán-Calenti, José C, additional, Kovacs, Elizabeth J, additional, Gostner, Johanna M, additional, Fuchs, Dietmar, additional, Brenner, Lisa A, additional, Lorenzo-López, Laura, additional, and Postolache, Teodor T, additional

Published
2023
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7. Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty.

Author

Mohyuddin, Hira, Laffon, Blanca, Teixeira, João P, Costa, Solange, Teixeira-Gomes, Armanda, Pásaro, Eduardo, Constantine, Niel, Dagdag, Aline, Ortmeyer, Heidi K, Tizenberg, Boris, Afram, Liubov, Yen, Poyu, Marano, Christopher, Lowry, Christopher A, Hoisington, Andrew J, RachBeisel, Jill A, Valdiglesias, Vanessa, Lema-Arranz, Carlota, Fernández-Bertólez, Natalia, and Maseda, Ana

Subjects
TUMOR necrosis factor receptors, TOXOPLASMA gondii, FRAILTY, GERIATRIC Depression Scale, IMMUNOGLOBULIN G, NEUROCYSTICERCOSIS
Abstract

Background Persistent inflammation related to aging ("inflammaging") is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty. Methods We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [ N = 601; age: mean (SD) 77.3 (8.0); 61% women]. Plasma T. gondii immunoglobulin G (IgG) serointensity was measured with an enzyme-linked immunosorbent assay. The Fried criteria were used to define frailty status. Validated translations of Mini-Mental State Examination, Geriatric Depression Scale, and the Charlson Comorbidity Index were used to evaluate confounders. Previously analyzed biomarkers that were significantly associated with frailty in both prior reports and the current study, and also related to T. gondii serointensity, were further accounted for in multivariable logistic models with frailty as outcome. Results In T. gondii -seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p =.0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p <.05). Associations with other biomarkers were not significant. Conclusions This first reported association between T. gondii and frailty is limited by a cross-sectional design and warrants replication. While certain biomarkers of inflammaging were associated with both T. gondii IgG serointensity and frailty, they did not fully mediate the T. gondii –frailty association. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Association of Torquetenovirus viremia with physical frailty and cognitive impairment in three independent European cohorts

Author

Giacconi, Robertina, primary, Laffon, Blanca, additional, Costa, Solange, additional, Teixeira-Gomes, Armanda, additional, Maggi, Fabrizio, additional, Macera, Lisa, additional, Spezia, Pietro Giorgio, additional, Piacenza, Francesco, additional, Bürkle, Alexander, additional, Moreno-Villanueva, Maria, additional, Bonassi, Stefano, additional, Valdiglesias, Vanessa, additional, Teixeira, João Paulo, additional, Dollé, Martijn E.T., additional, Rietman, M. Liset, additional, Jansen, Eugène, additional, Grune, Tilman, additional, Gonos, Efstathios S., additional, Franceschi, Claudio, additional, Capri, Miriam, additional, Weinberger, Birgit, additional, Sikora, Ewa, additional, Stuetz, Wolfgang, additional, Toussaint, Olivier, additional, Debacq-Chainiaux, Florence, additional, Hervonen, Antti, additional, Hurme, Mikko, additional, Slagboom, P. Eline, additional, Schön, Christiane, additional, Bernhardt, Juergen, additional, Breusing, Nicolle, additional, Pásaro, Eduardo, additional, Maseda, Ana, additional, Lorenzo-López, Laura, additional, Millán-Calenti, José C., additional, Provinciali, Mauro, additional, and Malavolta, Marco, additional

Published
2022
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19. Pain as a mediator in the temperament-alexithymia relationship in individuals suffering from rheumatoid arthritis

Author

Ziarko, M., Grobelny, Bartosz, Sikorska, B., Jasielska, A., Maseda, Ana, Millán-Calenti, José Carlos, Samborski, Wlodzimierz, Mojs, Ewa, and Piglowska, A.

Subjects
Alexithymia, Pain, Rheumatoid arthritis, Temperament
Abstract

[Abstract] OBJECTIVE: The study aims to establish a relationship between temperament traits, symptoms of alexithymia, and pain intensity in rheumatoid arthritis. Despite the significant progress seen in the area of RA treatment, pain, often life-long, remains the predominant symptom. This constant pain and progressing disability, as well as dependence upon other people cause RA patients to experience psychological stress that can be modified by individual patient traits. Recently, several authors have underlined the need to relate personality and temperament constructs to neurobiological processes that may underlie individual differences. It seems then that patient characteristics may play a significant role in the course of the disease. PATIENTS AND METHODS: The study was performed on a group of patients (N=317) with rheumatoid arthritis diagnosed according to the current criteria of the American-European Consensus of 2010. All patients expressed voluntary consent to participate, and the study protocol was approved by the Local Ethics Committee. This was a survey-based study. It involved the application of the adult version of the Buss and Plomin EAS Temperament Questionnaire (EAS-D), which tests 3 main temperament domains: sociability, activity, and emotionality. The pain was measured on the Visual Analogue Scale (VAS). VAS is used to measure pain intensity. The level of alexithymia was tested using the Toronto Alexithymia Scale-20. The scale consists of 20 statements and includes 3 subscales that measure difficulty in describing feelings/emotions, difficulty in identifying feelings/emotions, and operational externally oriented thinking. RESULTS: The analysis revealed that alexithymia is positively correlated only with one dimension of temperament, i.e., emotionality, and with pain intensity. Moreover, high emotionality was positively correlated with pain. A simple mediation analysis revealed that pain intensity functioned as a mediator in the emotionality-alexithymia relationship. CONCLUSIONS: The observed correlations indicate that RA patients with a high level of emotionality exhibit high alexithymia as they perceive pain related to the disease symptoms more intensely. The observed mediation is partial, meaning that there are also other mediating factors in this relationship.

Published
2021

25. Erratum to: Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis

Author

Tan, Benjamin Kye Jyn, primary, Eyn Kidd Man, Ryan, additional, Tau Liang Gan, Alfred, additional, Fenwick, Eva K, additional, Varadaraj, Varshini, additional, Swenor, Bonnielin K, additional, Gupta, Preeti, additional, Wong, Tien Yin, additional, Trevisan, Caterina, additional, Lorenzo-López, Laura, additional, Maseda, Ana, additional, Millán-Calenti, José Carlos, additional, Schwanke, Carla Helena Augustin, additional, Liljas, Ann, additional, Al Snih, Soham, additional, Tokuda, Yasuharu, additional, and Lamoureux, Ecosse Luc, additional

Published
2021
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34. Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis

Author

Tan, Benjamin Kye Jyn, primary, Man, Ryan Eyn Kidd, additional, Gan, Alfred Tau Liang, additional, Fenwick, Eva K, additional, Varadaraj, Varshini, additional, Swenor, Bonnielin K, additional, Gupta, Preeti, additional, Wong, Tien Yin, additional, Trevisan, Caterina, additional, Lorenzo-López, Laura, additional, Maseda, Ana, additional, Millán-Calenti, José Carlos, additional, Schwanke, Carla Helena Augustin, additional, Liljas, Ann, additional, Al Snih, Soham, additional, Tokuda, Yasuharu, additional, and Lamoureux, Ecosse Luc, additional

Published
2020
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47. Frailty in Older Adults Is Associated With Plasma Concentrations of Inflammatory Mediators but Not With Lymphocyte Subpopulations

Author

Marcos-Pérez, Diego, primary, Sánchez-Flores, María, additional, Maseda, Ana, additional, Lorenzo-López, Laura, additional, Millán-Calenti, José C., additional, Gostner, Johanna M., additional, Fuchs, Dietmar, additional, Pásaro, Eduardo, additional, Laffon, Blanca, additional, and Valdiglesias, Vanessa, additional

Published
2018
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48. Exploring Genetic Outcomes as Frailty Biomarkers

Author

Valdiglesias, Vanessa, primary, Sánchez-Flores, María, additional, Marcos-Pérez, Diego, additional, Lorenzo-López, Laura, additional, Maseda, Ana, additional, Millán-Calenti, José C, additional, Pásaro, Eduardo, additional, and Laffon, Blanca, additional

Published
2018
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50. Optimal nonpharmacological management of agitation in Alzheimer’s disease: challenges and solutions

Author

Millan-Calenti, José Carlos, Lorenzo-López,Laura, Alonso-Búa,Begoña, de Labra Pinedo,Carmen, González-Abraldes,Isabel, and Maseda,Ana

Subjects
Clinical Interventions in Aging
Abstract

José Carlos Millán-Calenti,1 Laura Lorenzo-López,1 Begoña Alonso-Búa,1 Carmen de Labra,2 Isabel González-Abraldes,1 Ana Maseda1 1Gerontology Research Group, Department of Medicine, Faculty of Health Sciences, Universidade da Coruña, A Coruña, Spain; 2Research, Development and Innovation Department, Gerontological Complex La Milagrosa, Provincial Association of Pensioners and Retired People (UDP) from A Coruña, A Coruña, Spain Abstract: Many patients with Alzheimer’s disease will develop agitation at later stages of the disease, which constitutes one of the most challenging and distressing aspects of dementia. Recently, nonpharmacological therapies have become increasingly popular and have been proven to be effective in managing the behavioral symptoms (including agitation) that are common in the middle or later stages of dementia. These therapies seem to be a good alternative to pharmacological treatment to avoid unpleasant side effects. We present a systematic review of randomized controlled trials (RCTs) focused on the nonpharmacological management of agitation in Alzheimer’s disease (AD) patients aged 65 years and above. Of the 754 studies found, eight met the inclusion criteria. This review suggests that music therapy is optimal for the management of agitation in institutionalized patients with moderately severe and severe AD, particularly when the intervention includes individualized and interactive music. Bright light therapy has little and possibly no clinically significant effects with respect to observational ratings of agitation but decreases caregiver ratings of physical and verbal agitation. Therapeutic touch is effective for reducing physical nonaggressive behaviors but is not superior to simulated therapeutic touch or usual care for reducing physically aggressive and verbally agitated behaviors. Melissa oil aromatherapy and behavioral management techniques are not superior to placebo or pharmacological therapies for managing agitation in AD. Further research in clinical trials is required to confirm the effectiveness and long-term effects of nonpharmacological interventions for managing agitation in AD. These types of studies may lead to the development of future intervention protocols to improve the well-being and daily functioning of these patients, thereby avoiding residential care placement. Keywords: dementia, nonpharmacological, behavioral and psychological symptoms

Published
2016

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